A preparation method of traditional Chinese medicine for treating bone injury

Abstract

The invention provides a method for preparing a Chinese medicine for treating bone injuries, comprising: (1) preparing materials: goat horn powder, earthworm powder, artificial musk powder, myrrh powder, indigo powder and thick paste, which are prepared by taking Chuanxiong, Drynaria and Angelica dahurica as raw materials, soaking in ethanol, ultrasonic extraction and concentrating; (2) preparing the paste: taking a water-in-oil matrix and putting it into a reactor, adding the thick paste when the matrix melts to a semi-fluid state, and then slowly adding goat horn powder, earthworm powder, myrrh powder and indigo powder into the reactor, continuing to stir until the mixture is uniform, and obtaining a mixed paste, when the temperature of the mixed paste is less than 50°C, adding artificial musk powder, continuing to stir evenly, and when the temperature of the paste is room temperature, taking it out and storing it to obtain a water-in-oil type bone injury quick healing paste. The therapeutic effect of the invention has the advantages of quick pain relief, quick dissipation of blood stasis, quick dissipation of swelling, quick fracture healing, quick establishment of circulation at the injured part, quick formation of bone callus, quick disappearance of fracture line, small formation of bone callus, and high bone density of new bone at the fracture part.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine prescriptions for bone injuries, and in particular to a method for preparing a traditional Chinese medicine for treating bone injuries. Background Art

[0002] Closed bone injuries and fractures refer to the interruption of bone integrity and continuity caused by external trauma to the human body. Soft tissue injuries are relatively minor and are often accompanied by bone rubbing sounds and bone rubbing sensations, which lead to local pain, congestion and swelling in patients. Severe multiple fractures may even lead to shock and endanger life. Sprains and contusions of tendons and soft tissues refer to injuries to muscles, tendons, joints, fascia and other tissues accompanied by bone destruction caused by external forces of external factors, which usually manifest as local swelling, congestion and pain.

[0003] At present, Western medicine usually treats patients with closed bone injuries and fractures by surgically cutting open the affected area and implanting special equipment for internal fixation, or by using traditional methods to reduce the fracture, and then using plaster or splints for external fixation to achieve the treatment purpose; however, after the bone injury heals, the implanted fixation device needs to be removed surgically, which not only causes secondary trauma to the patient, but also incurs high costs. In addition, most of the cured patients are prone to repeated swelling, pain, coldness and other sequelae in the affected area in the following 1-3 years or longer when participating in physical labor or encountering cold and rainy weather, and these sequelae cannot be resolved.

[0004] It can be seen that whether it is traditional Chinese medicine, Western medicine or a combination of traditional Chinese and Western medicine, the clinical treatment effect on closed bone injuries and fractures is good. However, the treatment effect on the sequelae of closed bone injuries and fractures is not ideal. Summary of the invention

[0005] In view of the above-mentioned deficiencies of the prior art, the present invention provides a method for preparing a Chinese medicine for treating bone injuries, comprising crushing raw materials, preparing a thick paste and preparing an ointment, wherein the ointment is an oil-in-water ointment. In the prescription of the present invention, through the scientific and reasonable compatibility of various medicines, each medicine has a good synergistic effect in terms of therapeutic effect, and finally has a good therapeutic effect of cooling blood and detoxifying, dispersing blood and removing blood stasis, removing blood stasis, reducing swelling and relieving pain, and connecting bones and tendons. Compared with modern technology, the therapeutic effect of the present invention has the advantages of fast pain relief, fast dissipation of blood stasis, fast dissipation of swelling, fast fracture healing, fast establishment of circulation at the injured part, fast formation of bone callus, fast disappearance of fracture line, small formation of bone callus, and high bone density of new bone at the fracture part.

[0006] The technical solution of the present invention is as follows:

[0007] A method for preparing a traditional Chinese medicine for treating bone injuries, the process is as follows:

[0008] (1) Preparation:

[0009] Goat horns: caramelize them in a microwave, let them cool, and then crush them for later use;

[0010] Bake the cleaned ground beetles in a microwave oven for 5-8 minutes, let them cool, and then crush them for later use;

[0011] Artificial musk: bake the artificial musk in an infrared oven at 120℃ for 5-6 minutes, let it cool, and then crush it for later use;

[0012] Myrrh, crushed and set aside;

[0013] Indigo, crush and set aside;

[0014] Thick paste, made from Chuanxiong, Drynaria fortunei and Angelica dahurica, soaked in ethanol, extracted by ultrasonic and concentrated;

[0015] (2) Preparation of ointment:

[0016] Put the water-in-oil matrix into a reactor, heat it at 70°C, add the thick paste when the matrix melts to a semi-fluid state, start stirring at 300r / min for 6-10min, then stop heating, adjust the stirring speed to 100r / min, slowly add goat horn powder, earthworm powder, myrrh powder and indigo powder into the reactor, continue stirring until mixed evenly to obtain a mixed paste, when the temperature of the mixed paste is less than 50°C, add artificial musk powder, continue stirring evenly, when the temperature of the paste is room temperature, take out and store to form a water-in-oil type bone injury quick-healing ointment.

[0017] Preferably, each 100g of bone injury quick healing ointment is prepared from the following components by weight:

[0018] 350g of earthworm, 200g of myrrh, 600g of processed goat horn powder, 300g of Chuanxiong, 500g of Drynaria, 300g of Angelica dahurica, 20g of artificial musk, and 30g of Indigo.

[0019] The Chinese herb Eupolyphaga has strong abilities to move, break blood, remove blood stasis, reconnect tendons and bones, reduce swelling and relieve pain, and promote the activity of bone-forming cells and increase the number of cells in the treatment of bone injuries and fractures. It is the main medicine. Myrrh has the ability to promote blood circulation and remove blood stasis, and has the functions of regenerating muscles and tendons and relieving pain. When used in combination with the Chinese herb Eupolyphaga, in addition to promoting blood circulation and removing blood stasis, it has the ability to repair damaged muscles, tendon cells and regenerate muscles, making up for the deficiency of the main medicine. It is the "secondary" medicine. The two medicines are used together, and the "main" and "secondary" effects complement each other. The two medicines are used together to break blood, disperse blood stasis, remove blood stasis, regenerate muscles, reconnect tendons and bones and relieve pain. They are the main medicine.

[0020] Goat horn is cool in nature, and can relieve fever, disperse blood stasis, and relieve pain. It has the effect of delaying tissue cell necrosis, and can remove dead blood caused by blood stasis deposited after injury. This prescription uses it to enhance the effects of the main medicine in cooling blood, dispersing blood, and detoxifying. It can disperse the dead blood caused by bone injury without leaving any stasis. At the same time, it helps the main medicine to break blood, expel blood stasis, remove blood stasis, regenerate tissue and relieve pain, taking into account the special effects of cooling blood, dispersing blood stasis, and removing dead blood stasis, and achieves the good therapeutic effect of bone and tendon connection as the assistant medicine.

[0021] Drynaria fortunei warms and nourishes the kidney yang, strengthens the tendons and bones, and promotes blood circulation and relieves pain. It is an important medicine for treating bruises, fractures and tendon injuries. It can assist the main medicine in treating bone injuries and fractures, promote the healing of bone injuries and tendon and bone injuries, and can make up for the insufficient efficacy of the auxiliary medicine and serve as an adjuvant.

[0022] Chuanxiong is warm in nature, can invigorate blood circulation and relieve pain, and is a blood-activating and blood-stasis-removing drug. It is the key drug for invigorating blood circulation and promoting qi. When qi moves, blood moves, blood stasis disappears, and when blood moves, pain is relieved. Therefore, Chuanxiong must be used to achieve the best therapeutic effect in dispersing blood stasis, dissolving blood stasis, removing blood stasis, and connecting bones and tendons. It is also the "main agent" drug.

[0023] Angelica dahurica is warm in nature and is good at moving the meridians and collaterals to relieve swelling and relieve pain. When used with Chuanxiong, it helps Chuanxiong move the meridians and collaterals to enhance its strong effect of relieving swelling and relieving pain, and highlights its good effects of relieving pain and removing blood stasis quickly, making it a "helper" drug. Therefore, Chuanxiong and Angelica dahurica are used together as helpers.

[0024] Artificial musk is pungent and warm, and can detoxify. It is an important medicine in surgery for healing sores, promoting blood circulation, opening the orifices, dredging meridians, relieving pain and reducing swelling. It also has the ability to detoxify.

[0025] Indigo can clear away heat and detoxify, cool blood, disperse blood, and stop bleeding. The combination of the two medicines has the functions of cooling blood and detoxifying, dispersing blood, promoting tissue regeneration and healing sores, promoting blood circulation, unblocking meridians and relieving pain, making up for the lack of the main medicine, the lack of the auxiliary medicine, and the inability of the adjuvant medicine, so as to achieve the good therapeutic effect that the main medicine does not have. Therefore, it is a subordinate medicine.

[0026] In the formula of the present invention, goat horn, earthworm, and indigo all have the functions of cold, detoxification, and blood stasis. Combined with modern pharmacological research, it is found that when the body is damaged, the damaged tissue will produce "heat toxicity". In order to control the "heat-producing" and "toxic" substances, modern therapies have cryotherapy and cold compress therapy to achieve the effects of fast swelling reduction, tendon fracture injury, and fast repair of injury. Studies have shown that the key factor affecting the speed of bone injury and fracture healing is the length of time for local swelling, blood stasis, and pain to dissipate after bone injury and fracture. In other words, the time for establishing normal blood circulation at the injured part is the key factor affecting the length of time for bone injury and fracture healing. Therefore, the formula of the present invention is different from the traditional Chinese medicine formula in that it is characterized by the method of particularly strengthening cooling blood, detoxification, and blood stasis. Therefore, goat horn, earthworm, and indigo are combined in the prescription, and the effects of cold detoxification and blood stasis are taken as the medicine. In order to achieve a new idea and method for treating bone injury, fracture, tendon and soft tissue sprain and contusion, which is quick and effective, and has good efficacy. The above medicines have: monarch, minister, adjuvant, messenger, accompanying and necessary medicines, which are reasonably matched to achieve the special therapeutic effects of cooling blood and detoxifying, dispersing blood and removing blood stasis, resolving blood stasis, removing blood stasis, reducing swelling and relieving pain, and setting bones and tendons.

[0027] Preferably, the production process of goat horn powder is: take a goat horn (original dried horn), cut off the ossified part of 5-8 cm at the root, put it in a microwave oven and heat it for 15-30 minutes until the goat horn is completely charred, let it cool, and grind it into fine powder of more than 120 mesh using an ultra-fine grinder.

[0028] Preferably, the earthworm powder is a fine powder of 120 mesh or more, the artificial musk powder is a fine powder of 120 mesh or more, the myrrh powder is a fine powder of 120 mesh or more, and the indigo powder is a fine powder of 120 mesh or more.

[0029] Preferably, the preparation process of the thick paste is as follows:

[0030] S1, taking the purified Chuanxiong, Drynaria fortunei and Angelica dahurica, crushing them to obtain a mixed material, and setting aside;

[0031] s 2, soaking the mixture in 75% ethanol solution for 72-84 hours to obtain mixture A for standby use;

[0032] s 3, placing mixture A in an ultrasonic extraction tank, and ultrasonically extracting at 40° C. for 2-3 times, each extraction time being 25-30 minutes, to obtain mixture B for later use;

[0033] s 4, filter the mixture B, collect the filtrate, and concentrate the filtrate to a viscous state to obtain a thick paste.

[0034] Preferably, in step s1, the mixture is 30-mesh particles; and the mass volume ratio (g / mL) of the mixture to 75% ethanol is 1:3-5.

[0035] Preferably, in step s4, the mixture B is filtered by centrifugal filtration, the collected filtrate is placed in an ultrasonic extraction tank, and ethanol is distilled and recovered at 70-80°C to obtain 500 mL of thick paste.

[0036] Preferably, the oil-in-water matrix complies with GB 29665 (o / w) standard.

[0037] Preferably, the mass volume ratio (g / mL) of the oil-in-water base to the thick paste is 5-6:1.

[0038] Compared with the prior art, the beneficial effects of the present invention are:

[0039] 1. In the prescription of the present invention, through the scientific and reasonable compatibility of various medicines, the various medicines produce a good synergistic effect in therapeutic effect, and finally play a good therapeutic effect of cooling blood and detoxifying, dispersing blood and removing blood stasis, removing blood stasis, reducing swelling and relieving pain, and connecting bones and tendons. Compared with modern technology, the therapeutic effect characteristics of the present invention are: fast pain relief, fast dissipation of blood stasis, fast dissipation of swelling, fast fracture healing, fast establishment of circulation at the injured part, fast callus formation, fast disappearance of fracture line, small callus formation, and high bone density of new bone at the fracture part.

[0040] 2. The prescription of the present invention has the advantages of high cure rate, no side effects, low price, and treating both the symptoms and the root causes. It is a new idea and method for treating closed bone injuries and fractures, as well as sprains and contusions of tendons and bone tissues.

[0041] 3. The Chinese medicine composition provided by the present invention has the characteristics of good stability, rheology, heat preservation, adhesion and storage properties; the Chinese medicine combination provided by the present invention can be made into dosage forms such as vaseline ointment, water-in-oil ointment, traditional black plaster, rosin-based plaster or external Chinese medicine bag, stored at room temperature, with a shelf life of three years. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 This is an X-ray film taken 7 weeks after simple manual reduction and plaster external fixation.

[0043] Figure 2 X-ray film was taken after 7 weeks of using the external ointment of the present invention (Example 1). DETAILED DESCRIPTION

[0044] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0045] Example 1

[0046] A method for preparing a traditional Chinese medicine for treating bone injuries, the process is as follows:

[0047] (1) Preparation:

[0048] Goat horn: take the original dried goat horn, cut off the ossified part of 5-8 cm at the root, weigh 600g, put it in a microwave oven and heat it for 25 minutes until the goat horn is completely charred, let it cool, and grind it into fine powder with an ultra-fine grinder with a mesh size of more than 120, and set aside;

[0049] Earthworms: weigh 350 g of the purified earthworms, bake them in a microwave oven for 7 minutes, let them cool, and grind them into fine powder with a superfine grinder with a mesh size of 120 or more for later use;

[0050] Artificial musk: weigh 20g of artificial musk, bake it in an infrared oven at 120℃ for 5 minutes, let it cool, and then grind it into fine powder with a superfine grinder with a mesh size of more than 120 for later use;

[0051] Myrrh: weigh 200g of myrrh and grind it into fine powder with a superfine grinder with a mesh size of 120 or above, and set aside;

[0052] Indigo: weigh 30g of Indigo and grind it into fine powder with a superfine grinder of 120 mesh or larger, and set aside;

[0053] Thick paste, the preparation process is as follows:

[0054] s 1, take 300g of purified Chuanxiong, 500g of Drynaria fortunei, and 300g of Angelica dahurica, grind them to obtain a mixture and 30-mesh granules for later use;

[0055] s 2, soaking the mixture in 4 L of 75% ethanol solution for 72 hours to obtain a mixture A for later use;

[0056] s 3, placing mixture A in an ultrasonic extraction tank, and ultrasonically extracting twice at 40°C, each extraction time being 25 minutes, to obtain mixture B for later use;

[0057] s 4, filtering the mixture B by centrifugal filtration, collecting the filtrate and placing the filtrate in an ultrasonic extraction tank, distilling and recovering ethanol at 75° C., and obtaining 500 mL of a thick paste;

[0058] (2) Preparation of ointment:

[0059] Take 2500g of water-in-oil matrix, which meets the GB 29665 (o / w) standard, put it into a reactor, heat it at 70°C, add a thick paste when the matrix melts to a semi-fluid state, start stirring at 300r / min for 6 minutes, then stop heating, adjust the stirring speed to 100r / min, slowly add goat horn powder, earthworm powder, myrrh powder and indigo powder into the reactor, continue stirring until mixed evenly, and obtain a mixed paste. When the temperature of the mixed paste is less than 50°C, add artificial musk powder, continue stirring evenly, and when the paste temperature is room temperature, take it out and store it to obtain a water-in-oil type bone injury quick-healing ointment.

[0060] Example 2

[0061] A method for preparing a traditional Chinese medicine for treating bone injuries, the process is as follows:

[0062] (1) Preparation:

[0063] Goat horn: take the original dried goat horn, cut off the ossified part of 5-8 cm at the root, weigh 600g, put it in a microwave and heat it for 15 minutes until the goat horn is completely charred, let it cool, and grind it into fine powder with an ultra-fine grinder with a mesh size of more than 120, and set aside;

[0064] Eupolyphaga sinensis: weigh 350 g of purified Eupolyphaga sinensis, bake in a microwave oven for 5 minutes, let cool, and grind into fine powder with an ultra-fine grinder with a mesh size of 120 or more for later use;

[0065] Artificial musk: weigh 20g of artificial musk, bake it in an infrared oven at 120℃ for 5 minutes, let it cool, and then grind it into fine powder with a superfine grinder with a mesh size of more than 120 for later use;

[0066] Myrrh: weigh 200g of myrrh and grind it into fine powder with a superfine grinder with a mesh size of 120 or above, and set aside;

[0067] Indigo: weigh 30g of Indigo and grind it into fine powder with a superfine grinder of 120 mesh or larger, and set aside;

[0068] Thick paste, the preparation process is as follows:

[0069] s 1, take 300g of purified Chuanxiong, 500g of Drynaria fortunei, and 300g of Angelica dahurica, grind them to obtain a mixture and 30-mesh granules for later use;

[0070] s 2, soaking the mixture in 3.3 L of 75% ethanol solution for 80 hours to obtain a mixture A for later use;

[0071] s 3, placing mixture A in an ultrasonic extraction tank, and ultrasonically extracting for 3 times at 40°C, each extraction time being 30 minutes, to obtain mixture B for later use;

[0072] s 4, filtering the mixture B by centrifugal filtration, collecting the filtrate and placing the filtrate in an ultrasonic extraction tank, distilling and recovering ethanol at 70° C., and obtaining 500 mL of a thick paste;

[0073] (2) Preparation of ointment:

[0074] Take 3000g of water-in-oil matrix, which meets the GB 29665 (o / w) standard, put it into a reactor, heat it at 70°C, add a thick paste when the matrix melts to a semi-fluid state, start stirring at 300r / min for 8min, then stop heating, adjust the stirring speed to 100r / min, slowly add goat horn powder, earthworm powder, myrrh powder and indigo powder into the reactor, continue stirring until mixed evenly, and obtain a mixed paste. When the temperature of the mixed paste is less than 50°C, add artificial musk powder, continue stirring evenly, and when the temperature of the paste is room temperature, take it out and store it to obtain a water-in-oil type bone injury quick-healing ointment.

[0075] Example 3

[0076] A method for preparing a traditional Chinese medicine for treating bone injuries, the process is as follows:

[0077] (1) Preparation:

[0078] Goat horn: take the original dried goat horn, cut off the ossified part of 5-8 cm at the root, weigh 600g, put it in a microwave oven and heat it for 30 minutes until the goat horn is completely charred, let it cool, and grind it into fine powder with an ultra-fine grinder with a mesh size of more than 120, and set aside;

[0079] Earthworms: weigh 350 g of the purified earthworms, bake them in a microwave oven for 8 minutes, let them cool, and then grind them into fine powder with a superfine grinder of more than 120 meshes for later use;

[0080] Artificial musk: weigh 20g of artificial musk, bake it in an infrared oven at 120℃ for 5 minutes, let it cool, and then grind it into fine powder with a superfine grinder with a mesh size of more than 120 for later use;

[0081] Myrrh: weigh 200g of myrrh and grind it into fine powder with a superfine grinder with a mesh size of 120 or above, and set aside;

[0082] Indigo: weigh 30g of Indigo and grind it into fine powder with a superfine grinder of 120 mesh or larger, and set aside;

[0083] Thick paste, the preparation process is as follows:

[0084] s 1, take 300g of purified Chuanxiong, 500g of Drynaria fortunei, and 300g of Angelica dahurica, grind them to obtain a mixture and 30-mesh granules for later use;

[0085] s 2, soaking the mixture in 5 L of 75% ethanol solution for 84 hours to obtain a mixture A for later use;

[0086] s 3, placing mixture A in an ultrasonic extraction tank, and ultrasonically extracting twice at 40°C, each extraction time being 25 minutes, to obtain mixture B for later use;

[0087] s 4, filtering the mixture B by centrifugal filtration, collecting the filtrate and placing the filtrate in an ultrasonic extraction tank, distilling and recovering ethanol at 80° C., and obtaining 500 mL of a thick paste;

[0088] (2) Preparation of ointment:

[0089] Take 2500g of water-in-oil matrix, which meets the GB 29665 (o / w) standard, put it into a reactor, heat it at 70°C, add a thick paste when the matrix melts to a semi-fluid state, start stirring at 300r / min for 10 minutes, then stop heating, adjust the stirring speed to 100r / min, slowly add goat horn powder, earthworm powder, myrrh powder and indigo powder into the reactor, continue stirring until mixed evenly, and obtain a mixed paste. When the temperature of the mixed paste is less than 50°C, add artificial musk powder, continue stirring evenly, and when the paste temperature is room temperature, take it out and store it to obtain a water-in-oil type bone injury quick-healing ointment.

[0090] Comparative Example 1

[0091] The difference from Example 1 is that during the material preparation process in step (1):

[0092] Goat horn: take the original dried goat horn, cut off the ossified part of 5-8 cm at the root, weigh 600g, and grind it into fine powder with a superfine grinder with a mesh size of more than 120, and set aside;

[0093] Weigh 350 g of the purified ground beetle, grind it into fine powder with a superfine grinder with a mesh size of 120 or above, and set aside;

[0094] Artificial musk: weigh 20g of artificial musk, grind it into fine powder of more than 120 mesh using an ultra-fine grinder, and set aside.

[0095] The remaining steps not listed are the same as those in Example 1 and will not be described in detail.

[0096] Comparative Example 2

[0097] The difference from Example 1 is that

[0098] Thick paste, during preparation:

[0099] s 1, take 300g of purified Chuanxiong, 500g of Drynaria fortunei, and 300g of Angelica dahurica, grind them to obtain a mixture and 30-mesh granules for later use;

[0100] s 2, soaking the mixture in 4 L of 75% ethanol solution for 72 hours to obtain a mixture A for later use;

[0101] s 3, filtering the mixture A by centrifugal filtration, collecting the filtrate and placing the filtrate in an ultrasonic extraction tank, distilling and recovering ethanol at 75° C., and obtaining 500 mL of a thick paste;

[0102] The remaining steps not listed are the same as those in Example 1 and will not be described in detail.

[0103] Comparative Example 3

[0104] The difference from Example 1 is that

[0105] Thick paste, during preparation:

[0106] s 1, take 300g of purified Chuanxiong, 500g of Drynaria fortunei, and 300g of Angelica dahurica, grind them to obtain a mixture and 30-mesh granules for later use;

[0107] s 2, placing the mixture in 4 L of 75% ethanol solution to obtain mixture A for later use;

[0108] s 3, placing mixture A in an ultrasonic extraction tank, and ultrasonically extracting twice at 40°C, each extraction time being 25 minutes, to obtain mixture B for later use;

[0109] s 4, filtering the mixture B by centrifugal filtration, collecting the filtrate and placing the filtrate in an ultrasonic extraction tank, distilling and recovering ethanol at 75° C., and obtaining 500 mL of a thick paste;

[0110] The remaining steps not listed are the same as those in Example 1 and will not be described in detail.

[0111] Clinical trials

[0112] 1. Usage: For patients, manual reduction of bone fractures is performed, and the fractures are observed on a small C-arm X-ray. The alignment line is good, and the ointment obtained in Example 1 is applied to the fractured part, with a thickness of about 1 mm. After covering with auxiliary materials, splints, plaster or orthopedic external fixation and traction equipment are used according to the situation. Repeat the application of the bone injury quick-healing ointment once every 72 hours. When applying the ointment, the movements should be light, accurate and steady to prevent the fracture ends from being dislocated again.

[0113] 2. Clinical evaluation of the efficacy of patients with bone fractures:

[0114] ① Evaluate the patient's pain onset time and pain duration.

[0115] ② Evaluate the swelling and congestion of the affected area 3, 9, and 15 days after treatment.

[0116] ③ X-rays of the affected part were taken at 2, 4, 6, and 8 weeks after treatment to conduct clinical evaluation of fracture healing.

[0117] 3. Observation of therapeutic effect:

[0118] Methods: Clinical screening of 122 patients with bone injuries and fractures admitted to the Department of Traditional Chinese Medicine of Wolong District Traditional Chinese Medicine Hospital of Nanyang City from March 2016 to May 2021, including 76 cases of limb shaft fractures, 26 cases of rib fractures, and 20 cases of clavicle fractures. They were randomly divided into a treatment group of 61 cases and a control group of 61 cases. The control group was treated with manual reduction and external fixation alone, and the treatment group was treated with "Bone Injury Quick Healing Paste (Ointment obtained in Example 1)" on the basis of the control group. The pain disappearance time, congestion and swelling dissipation time, and fracture healing of the two groups of patients were counted, and the data were statistically analyzed. Results: The treatment group was significantly better than the control group in pain disappearance time, congestion and swelling dissipation time, and fracture healing time, and there was a significant difference in statistical analysis (P < 0.001); Conclusion "Bone Injury Quick Healing Paste" has a good effect in the treatment of fractures.

[0119] 4. Test results

[0120] Table 1 Statistical t test of pain status in two groups of patients

[0121] Group Number of cases Pain score (points) Pain duration (h) Analgesic onset time (h) Treatment Group 61 7.18±1.41 7.66±1.39 0.83±0.75 Control group 61 7.17±1.56 322.89±83.56 21.28±10.71 t - 0.0368 29.4601 14.8767 p - ＞0.05 ＜0.001 ＜0.001

[0122] Table 1 is the statistical record of pain conditions in the two groups of patients, using the VAS pain scoring standard (0-10 points); the patients in the treatment group achieved complete pain relief in as fast as 2 hours, with an average of 7.66±1.39 hours.

[0123] Table 2 Comparison of swelling degree between the two groups of patients after treatment

[0124]

[0125] Table 2 shows the degree of swelling of the affected area at different time points after treatment in the two groups of patients. The swelling and congestion disappeared within 15 days at the latest in the treatment group.

[0126] Table 3 Comparison of clinical stages of fracture healing between the two groups of patients at different treatment stages

[0127]

[0128] Table 3 shows the comparison of clinical stages of fracture healing between the two groups of patients at 2, 4, 6, and 8 weeks of treatment. All patients in the treatment group achieved stage III healing within 8 weeks at the latest.

[0129] After using the ointment provided in Example 1, the new bone density at the fracture site is high;

[0130] Figure 1 The patient, Wang Moulin, female, 37 years old, accidentally fell while riding an electric bike in January 2021, resulting in a fracture of the radial head. After simple manual reduction and plaster external fixation for 7 weeks, X-rays showed blurred fracture lines, original callus formation, and discontinuity of some cortical bones;

[0131] Figure 2 The patient is Zhang Moupei, a 35-year-old female who fell in April 2021 and fractured the radial head. After applying the ointment of the present invention (Example 1) for 7 weeks, the fracture line disappeared and the callus was well formed on X-ray.

[0132] It can be seen that the ointment provided by the present invention can improve the density of new bones after use.

[0133] Analysis of the compatibility of prescriptions and medicines: The earthworm in the prescription is salty and cold, while myrrh is neutral. The combination of the two medicines has good therapeutic effects of breaking blood, removing blood stasis, promoting tissue regeneration and relieving pain, and connecting bones and tendons.

[0134] Treatment basis: cooling blood and detoxifying, dispersing blood stasis, resolving blood stasis, removing blood stasis, reducing swelling and relieving pain, and setting bones and tendons.

[0135] The Chinese medicine combination of the present invention is suitable for the following indications: acute and chronic bone injuries and fractures, sprains and contusions of soft tissues, tendons and bones, and poor healing of sequelae of old bone injuries and fractures; and patients with closed bone injuries, fractures, and sprains and contusions of tendons and bones.

[0136] Although the present invention has been described in detail by reference to the preferred embodiments, the present invention is not limited thereto. Without departing from the spirit and essence of the present invention, a person of ordinary skill in the art may make various equivalent modifications or substitutions to the embodiments of the present invention, and these modifications or substitutions shall be within the scope of the present invention. Any person of ordinary skill in the art may easily think of changes or substitutions within the technical scope disclosed by the present invention, and these shall be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of protection of the claims.

Claims

1. A method for preparing a traditional Chinese medicine for treating bone fractures, characterized in that: The process is as follows: (1) Preparation of materials: Goat horns: caramelize them in a microwave, let them cool, and then crush them for later use; Bake the cleaned ground beetles in a microwave oven for 5-8 minutes, let them cool, and then crush them for later use; Artificial musk: bake the artificial musk in an infrared oven at 120℃ for 5-6 minutes, let it cool, and then crush it for later use; Myrrh, crushed and set aside; Indigo, crush and set aside; Thick paste, made from Chuanxiong, Drynaria fortunei and Angelica dahurica, soaked in 75% ethanol, extracted by ultrasonic and concentrated; (2) Preparation of ointment: Put the oil-in-water matrix into a reactor, heat it at 70°C, add the thick paste when the matrix melts to a semi-fluid state, start stirring at 300r / min for 6-10min, then stop heating, adjust the stirring speed to 100r / min, slowly add goat horn powder, earthworm powder, myrrh powder and indigo powder into the reactor, continue stirring until mixed evenly, and obtain a mixed paste. When the temperature of the mixed paste is less than 50°C, add artificial musk powder, continue stirring evenly, and when the paste temperature reaches room temperature, take it out and store it to obtain an oil-in-water bone injury ointment. The bone injury ointment is prepared from the following components by weight: 350g of earthworm, 200g of myrrh, 600g of processed goat horn powder, 300g of Chuanxiong, 500g of Drynaria, 300g of Angelica dahurica, 20g of artificial musk, and 30g of Indigo.

2. The method for preparing a Chinese medicine for treating bone fractures and injuries as claimed in claim 1, characterized in that: The production process of goat horn powder is as follows: take a rounded and dried goat horn, cut off the ossified part of 5-8 cm at the root, put it in a microwave and heat it for 15-30 minutes until the goat horn is completely charred, let it cool, and use an ultra-fine grinder to grind it into fine powder of more than 120 mesh.

3. The method for preparing a Chinese medicine for treating bone fractures and injuries as claimed in claim 1, characterized in that: The earthworm powder is a fine powder with a mesh size of 120 or more, the artificial musk powder is a fine powder with a mesh size of 120 or more, the myrrh powder is a fine powder with a mesh size of 120 or more, and the indigo powder is a fine powder with a mesh size of 120 or more.

4. The method for preparing a Chinese medicine for treating bone fractures and injuries according to claim 1, characterized in that: The preparation process of the thick paste is as follows: s1, taking the purified Chuanxiong, Drynaria fortunei and Angelica dahurica, crushing them to obtain a mixed material, and setting aside; s2, soaking the mixture in a 75% ethanol solution for 72-84 hours to obtain a mixture A for standby use; s3, placing mixture A in an ultrasonic extraction tank, and ultrasonically extracting at 40° C. for 2-3 times, each extraction time being 25-30 minutes, to obtain mixture B for later use; s4, filter the mixture B, collect the filtrate, and concentrate the filtrate to a viscous state to obtain a thick paste.

5. The method for preparing a traditional Chinese medicine for treating bone fractures and injuries as claimed in claim 4, characterized in that: In step s1, the mixture is 30-mesh particles; the mass volume (g / mL) ratio of the mixture to 75% ethanol is 1:3-5.

6. The method for preparing a traditional Chinese medicine for treating bone fractures and injuries as claimed in claim 4, characterized in that: In step s4, the mixture B is filtered by centrifugal filtration, and the collected filtrate is placed in an ultrasonic extraction tank, and ethanol is distilled and recovered at 70-80° C. to obtain 500 mL of thick paste.

7. The method for preparing a traditional Chinese medicine for treating bone fractures and injuries as claimed in claim 4, characterized in that: The oil-in-water matrix complies with GB 29665 (o / w) standard.

8. The method for preparing a traditional Chinese medicine for treating bone fractures and injuries according to claim 1, characterized in that: The mass volume ratio (g / mL) of the oil-in-water matrix to the thick paste is 5-6:1.

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