A Chinese medicine composition for treating cerebral apoplexy and its preparation method

Abstract

The present invention relates to the technical field of pharmaceutical compositions, and in particular to a Chinese medicine composition for treating cerebral stroke and a preparation method thereof. The present invention provides a Chinese medicine composition for treating cerebral stroke, which is prepared from the following components by mass: 20 to 26 parts of Gastrodia elata, 12 to 16 parts of Scolopendra subspinipes, 8 to 12 parts of Hawksbill turtle, 14 to 18 parts of Angelica sinensis, 10 to 16 parts of Millettia reticulata, 7 to 13 parts of Red Peony Root, 8 to 12 parts of Forsythia suspensa, 8 to 12 parts of Periostracum Cicadae, 6 to 10 parts of Radix Rehmanniae, 7 to 11 parts of Poria cocos, 7 to 11 parts of Eclipta prostrata, 4 to 8 parts of Semen Platycladi, and 3 to 7 parts of Polygala tenuifolia. The Chinese medicine composition for treating cerebral stroke provided by the present invention has excellent technical effects for treating cerebral stroke, quick effect, no recurrence after cure, and no toxic and side effects. It also has the effects of improving brain blood supply and promoting nerve function repair, and the therapeutic effect is equivalent to that of existing drugs.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical compositions, and in particular to a Chinese medicinal composition for treating cerebral apoplexy and a preparation method thereof. Background Art

[0002] Cerebral stroke, also known as cerebral infarction, is a neurological disease caused by acute blood circulation disorders in the brain. It is the name of acute cerebrovascular disease in traditional Chinese medicine. The name stroke originated from the cause of the disease. The most important functional and structural basic unit in the brain is the nerve cell, called a neuron.

[0003] Neurons and nerve cells are very fragile after a stroke, so the brain will be ischemic and hypoxic after a stroke. If the brain is ischemic or hypoxic for more than six minutes, the nerve cells will die irreversibly. Each nerve cell in the brain has a specific function. For example, terraced fields are nerve cells in the brain. The brain has various functions, just like crops can grow in terraced fields. This is related to the blood supply in the brain.

[0004] Stroke can cause serious damage or impairment of brain function, with some obvious symptoms such as dizziness, blurred vision, limb weakness, and relatively minor limb twitching and numbness; some very serious strokes can cause great damage to human health, and even lead to death. This means that stroke is directly related to neurological diseases, because stroke can directly lead to the death of nerve cells.

[0005] There have been many discussions on the etiology, pathogenesis and treatment of stroke by doctors of all dynasties. From the perspective of the development of etiology, it can be roughly divided into two stages. Before the Tang and Song Dynasties, the theory of "internal deficiency and evil invading" was mostly used, and the treatment generally adopted prescriptions and medicines that dispelled wind and evil and replenished the positive energy. For example, "Golden Chamber Synopsis" officially named this disease as stroke. It is believed that the cause of stroke is the emptiness of collaterals and the invasion of wind evil into the philtrum. The syndrome differentiation method created by it is very helpful for the diagnosis, treatment, judgment of the severity of the disease and estimation of the prognosis of stroke. After the Tang and Song Dynasties, especially during the Jin and Yuan Dynasties, many doctors based their theories on "internal wind", which was a major turning point in the etiology of stroke. Among them, Liu Hejian insisted that "the kidney water is insufficient, and the heart fire is violent"; Li Dongyuan believed that "the body is strong and the qi is weak, and the original qi is sick"; Qing Dynasty medical scientists Ye Tianshi, Shen Jinao, You Zaijing, Wang Qingren and others enriched the treatment methods and prescriptions of stroke and formed a relatively complete treatment principle for stroke. In the late Qing Dynasty and modern times, doctors such as Zhang Bolong, Zhang Shanlei and Zhang Xichun further realized that the main cause of this disease is the imbalance of yin and yang, the disorder of qi and blood, and the direct attack on the brain. Since then, the understanding of the etiology and pathogenesis of stroke and its treatment have been improved. In recent years, relatively unified standards and norms have been gradually formed for the prevention, diagnosis, treatment, rehabilitation and nursing of stroke, the treatment methods have been diversified, and the efficacy has been greatly improved.

[0006] There are many types of stroke, among which the most serious is liver yang hyperactivity and wind and fire disturbance. The main symptoms are: hemiplegia, numbness of one side or crooked mouth and tongue, dizziness and headache, flushed face, red eyes, bitter mouth and dry throat, irritability, red urine and dry stool, red or crimson tongue, and strong and stringy pulse. In the existing technology, the means of treating cerebral stroke are mostly Western medicine and surgical treatment, but Western medicine treatment not only needs to be taken for a long time, but also has great side effects, and surgical treatment has high risks.

[0007] Therefore, how to provide a Chinese medicine composition for treating cerebral stroke and cerebral stroke nerve damage to solve the technical problem of the lack of Chinese medicine drugs related to treating cerebral stroke in the prior art is an issue that technical personnel in this field urgently need to solve. Summary of the invention

[0008] The purpose of the present invention is to provide a Chinese medicine composition for treating cerebral apoplexy and a preparation method thereof.

[0009] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0010] The invention provides a traditional Chinese medicine composition for treating cerebral apoplexy, which is prepared from the following components in parts by weight: 20-26 parts of gastrodia elata, 12-16 parts of centipedes, 8-12 parts of hawksbill turtles, 14-18 parts of angelica sinensis, 10-16 parts of millettia reticulata, 7-13 parts of red peony root, 8-12 parts of forsythia, 8-12 parts of cicada shells, 6-10 parts of raw rehmannia, 7-11 parts of tuckahoe, 7-11 parts of eclipta herb, 4-8 parts of cypress seeds and 3-7 parts of polygala tenuifolia.

[0011] The present invention also provides the above-mentioned Chinese medicine composition for treating cerebral stroke, comprising the following steps:

[0012] (1) Gastrodia elata, centipede, hawksbill turtle, Chinese angelica, Millettia reticulata, red peony root, forsythia suspensa, cicada shell, raw rehmannia root, tuckahoe, eclipta prostrata, cycas rehmanniae, and polygala tenuifolia are mixed and ground to obtain material 1;

[0013] (2) mixing material 1 with water for ultrasonic extraction, filtering, and obtaining a filtrate and a filter residue;

[0014] (3) mixing the filter residue with water and boiling, and filtering to obtain an extract;

[0015] (4) combining the filtrate with the extract to obtain a Chinese medicine composition for treating cerebral stroke.

[0016] Preferably, the ground material in step (1) is passed through a 50-70 mesh sieve, and the material under the sieve is collected as material 1.

[0017] Preferably, the mass ratio of the material 1 to water in step (2) is 1:4-6.

[0018] Preferably, the temperature of the ultrasonic extraction in step (2) is 45-55°C.

[0019] Preferably, the ultrasonic extraction time in step (2) is 40 to 50 minutes.

[0020] Preferably, the frequency of the ultrasound in step (2) is 35-45 kHz.

[0021] Preferably, the mass ratio of the filter residue to water in step (3) is 1:3-5.

[0022] Preferably, the decocting time in step (3) is 2 to 4 hours.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The present invention aims at the treatment method of cerebral stroke: mainly calming the liver and extinguishing wind, clearing away heat and activating blood circulation, removing blood stasis, and nourishing the liver and kidney, supplemented by drugs for calming the mind and stabilizing the spirit.

[0025] Specifically, the Gastrodia elata added in the present invention, gastrodin as the effective monomer with the highest content among the active ingredients of Gastrodia elata, has a protective effect on brain cell damage, and the effect is rapid, and can effectively control the condition of stroke patients.

[0026] Centipede can dredge the meridians and calm the liver wind, which can stop the convulsions, so it has the effect of dispelling wind and relieving spasms. It is used for patients with acute and chronic convulsions and tetanus with spasms, convulsions, opisthotonos, etc.

[0027] Hawksbill turtle is the shell of the hawksbill turtle of the family Chelonoidis. It can not only clear away heat and detoxify, but also calm the liver and relieve convulsions. Therefore, it can be used to treat high fever, coma, delirium, convulsions caused by febrile diseases or acute convulsions due to hyperactivity of wind and yang, as well as symptoms of hyperactivity of yang in stroke.

[0028] The main effects of Chinese angelica are to replenish blood and activate blood circulation, regulate menstruation and relieve pain, and moisten the intestines and promote bowel movements. Millettia reticulata has the effects of promoting blood circulation and replenishing blood, regulating menstruation and relieving pain, and relaxing muscles and tendons. Red peony root has the effects of promoting blood circulation, cooling blood, and removing blood stasis; the combination of the three can promote blood circulation and remove blood stasis, clear away heat and detoxify, disperse wind and remove heat, and remove toxins and clear rashes. Together, they have the effects of clearing blood and detoxifying, reducing swelling and relieving itching.

[0029] Forsythia has the effects of clearing away heat and detoxifying, reducing swelling and dispersing stagnation, and dispersing wind-heat. Periostracum Cicadae has the effects of dispersing wind-heat, relieving sore throat, clearing rashes, improving eyesight and removing cataracts, and relieving spasms. Radix Rehmanniae, Poria, and Herba Ecliptae have the effects of nourishing the liver and kidney. Semen Platycladi has the effects of nourishing the heart and calming the mind, moistening the intestines and relieving constipation, and stopping sweating. Radix Polygalae has the effects of calming the mind and improving intelligence, connecting the heart and kidney, removing phlegm, and reducing swelling. Semen Platycladi and Radix Polygalae have the effects of calming the mind and stabilizing the mind when used together.

[0030] Main ingredients: Gastrodia elata, centipede, hawksbill turtle, Chinese angelica, Millettia reticulata, red peony root; Ministers: Forsythia suspensa, cicada shell; Adjuvants: Rehmannia glutinosa, Poria cocos, Eclipta prostrata; Envoys: Torreya grandis seed, Polygala tenuifolia.

[0031] The Chinese medicine composition for treating cerebral stroke provided by the present invention has excellent technical effects of treating cerebral stroke, has quick effect, does not recur after being cured, and has no toxic side effects. It can improve the blood supply to the brain and promote the repair of nerve function, and the therapeutic effect is equivalent to that of existing drugs. DETAILED DESCRIPTION

[0032] The invention provides a Chinese medicine composition for treating cerebral stroke, which is prepared from the following components by weight: 20-26 parts of Gastrodia elata, 12-16 parts of Scolopendra subspinipes, 8-12 parts of Hawksbill turtle, 14-18 parts of Angelica sinensis, 10-16 parts of Millettia reticulata, 7-13 parts of Red Peony Root, 8-12 parts of Forsythia suspensa, 8-12 parts of Periostracum cicadae, 6-10 parts of Radix Rehmanniae, 7-11 parts of Poria cocos, 7-11 parts of Eclipta prostrata, 4-8 parts of Semen Platycladi and 3-7 parts of Polygala tenuifolia.

[0033] Preferably, it is prepared from the following components in parts by weight: 21-25 parts of Gastrodia elata, 13-15 parts of Scolopendra subspinipes, 9-11 parts of Hawksbill turtle, 15-17 parts of Angelica sinensis, 11-15 parts of Millettia spatholobi, 8-12 parts of Red Peony Root, 9-11 parts of Forsythia suspensa, 9-11 parts of Periostracum Cicadae, 7-8 parts of Radix Rehmanniae, 8-10 parts of Poria cocos, 7-10 parts of Eclipta prostrata, 5-7 parts of Semen Platycladi and 4-6 parts of Polygala tenuifolia.

[0034] It is further preferably prepared from the following components in parts by weight: 22-24 parts of Gastrodia elata, 14 parts of Scolopendra subspinipes, 10 parts of Hawksbill turtle, 16 parts of Angelica sinensis, 12-14 parts of Millettia reticulata, 9-11 parts of Red Peony Root, 10 parts of Forsythia suspensa, 10 parts of Periostracum cicadae, 8 parts of Radix Rehmanniae, 9 parts of Poria cocos, 8-9 parts of Eclipta prostrata, 6 parts of Semen Platycladi and 2 parts of Polygala tenuifolia.

[0035] More preferably, it is prepared from the following components in parts by mass: 23 parts of Gastrodia elata, 14 parts of Scolopendra subspinipes, 10 parts of Hawksbill turtle, 16 parts of Angelica sinensis, 13 parts of Millettia reticulata, 10 parts of Red Peony Root, 10 parts of Forsythia suspensa, 10 parts of Periostracum cicadae, 8 parts of Rehmannia glutinosa, 9 parts of Poria cocos, 9 parts of Eclipta prostrata, 6 parts of Semen Platycladi and 2 parts of Polygala tenuifolia.

[0036] The present invention also provides a Chinese medicine composition for treating cerebral stroke, comprising the following steps:

[0037] (1) Gastrodia elata, centipede, hawksbill turtle, Chinese angelica, Millettia reticulata, red peony root, forsythia suspensa, cicada shell, raw rehmannia root, tuckahoe, eclipta prostrata, cycas rehmanniae, and polygala tenuifolia are mixed and ground to obtain material 1;

[0038] (2) mixing material 1 with water for ultrasonic extraction, filtering, and obtaining a filtrate and a filter residue;

[0039] (3) mixing the filter residue with water and boiling, and filtering to obtain an extract;

[0040] (4) The filtrate is combined with the extract to obtain a Chinese medicine composition for treating cerebral stroke.

[0041] In the present invention, the ground material in step (1) is passed through a 50-70 mesh sieve, and the material under the sieve is collected as material 1; preferably 54-66 mesh; more preferably 58-62 mesh; and more preferably 60 mesh.

[0042] In the present invention, the mass ratio of the material 1 to water in step (2) is 1:4-6, preferably 1:5.

[0043] In the present invention, the temperature of the ultrasonic extraction in step (2) is 45-55°C; preferably 47-53°C; more preferably 49-51°C; and more preferably 50°C.

[0044] In the present invention, the time of the ultrasonic extraction in step (2) is 40 to 50 min; preferably 42 to 48 min; more preferably 44 to 46 min; and more preferably 45 min.

[0045] In the present invention, the frequency of the ultrasound in step (2) is 35-45 kHZ, preferably 37-43 kHZ, more preferably 39-41 kHZ, and more preferably 40 kHZ.

[0046] In the present invention, the mass ratio of the filter residue to water in step (3) is 1:3-5, preferably 1:4.

[0047] In the present invention, the decocting time in step (3) is 2 to 4 hours, preferably 3 hours.

[0048] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0049] Example 1

[0050] A method for preparing a Chinese medicine composition for treating cerebral stroke, comprising the following steps:

[0051] (1) Mix 20 parts of Gastrodia elata, 12 parts of Scolopendra subspinipes, 8 parts of Hawksbill turtle, 14 parts of Angelica sinensis, 10 parts of Millettia reticulata, 7 parts of Red Peony Root, 8 parts of Forsythia suspensa, 8 parts of Periostracum Cicadae, 6 parts of Radix Rehmanniae, 7 parts of Poria cocos, 7 parts of Eclipta prostrata, 4 parts of Semen Platycladi, and 3 parts of Polygala tenuifolia, grind the ground material, pass it through a 50-mesh sieve, and collect the material under the sieve as Material 1;

[0052] (2) Mixing material 1 and water in a mass ratio of 1:4, ultrasonic extraction was performed at 45° C. for 40 min, and filtering was performed to obtain a filtrate and a filter residue; the frequency of the ultrasound was 35 kHz;

[0053] (3) mixing the filter residue with water in a mass ratio of 1:3 and boiling for 2 h, and filtering to obtain an extract;

[0054] (4) The filtrate is combined with the extract to obtain a Chinese medicine composition for treating cerebral stroke.

[0055] Example 2

[0056] A method for preparing a Chinese medicine composition for treating cerebral stroke, comprising the following steps:

[0057] (1) 26 parts of Gastrodia elata, 16 parts of Scolopendra subspinipes, 12 parts of Hawksbill turtle, 18 parts of Angelica sinensis, 16 parts of Millettia spatholobi, 13 parts of Red Peony Root, 12 parts of Forsythia suspensa, 12 parts of Periostracum Cicadae, 10 parts of Radix Rehmanniae, 11 parts of Poria cocos, 11 parts of Eclipta prostrata, 8 parts of Semen Platycladi, and 7 parts of Polygala tenuifolia were mixed and ground, and the ground material was passed through a 70-mesh sieve, and the material under the sieve was collected as Material 1;

[0058] (2) mixing material 1 with water in a mass ratio of 1:6, ultrasonically extracting at 55° C. for 50 min, filtering to obtain a filtrate and a filter residue; the frequency of the ultrasound is 45 kHz;

[0059] (3) mixing the filter residue with water in a mass ratio of 1:5 and boiling for 4 hours, and filtering to obtain an extract;

[0060] (4) The filtrate is combined with the extract to obtain a Chinese medicine composition for treating cerebral stroke.

[0061] Example 3

[0062] A method for preparing a Chinese medicine composition for treating cerebral stroke, comprising the following steps:

[0063] (1) 23 parts of Gastrodia elata, 14 parts of Scolopendra subspinipes, 10 parts of Hawksbill turtle, 16 parts of Angelica sinensis, 13 parts of Millettia spatholobi, 10 parts of Red Peony Root, 10 parts of Forsythia suspensa, 10 parts of Periostracum Cicadae, 8 parts of Radix Rehmanniae, 9 parts of Poria cocos, 9 parts of Eclipta prostrata, 6 parts of Semen Platycladi, and 2 parts of Polygala tenuifolia were mixed and ground, and the ground material was passed through a 60-mesh sieve, and the material under the sieve was collected as Material 1;

[0064] (2) mixing material 1 with water in a mass ratio of 1:5, ultrasonically extracting at 50° C. for 45 min, filtering to obtain a filtrate and a filter residue; the frequency of the ultrasound is 40 kHz;

[0065] (3) mixing the filter residue with water in a mass ratio of 1:4 and boiling for 3 hours, and filtering to obtain an extract;

[0066] (4) The filtrate is combined with the extract to obtain a Chinese medicine composition for treating cerebral stroke.

[0067] Experimental Example 1

[0068] 90 SD rats (Alvinas Biotech, catalog number: HR0009) from the same batch were selected, with a body weight range of 180-190 g. The rat cerebral ischemia model was prepared according to the method of "Jia Qiang, Shi Zuorong, Yang Hongjun. Improved suture embolism method for the construction of cerebral ischemia models of different strains of mice [J]. Chinese Journal of Traditional Chinese Medicine, 2014, 39(17): 3367."

[0069] The products obtained in Example 1, Example 2 and Example 3 were used as Experimental Group 1, Experimental Group 2 and Experimental Group 3. The method of use was intragastric administration once in the morning and evening every day, 2 ml each time.

[0070] At the same time, control group 1 and control group 2 were set up to explore the effects of pine nuts and polygala on the efficacy of the product.

[0071] Control group 1: other methods are the same as those in Example 3, except that no cypress seeds are used; the method of use is the same as that in Example 3.

[0072] Control group 2: other methods are the same as those in Example 3, except that Semen Platycladi and Radix Polygalae were not used; the method of use is the same as that in Example 3.

[0073] At the same time, control group 3 and control group 4 were set up to explore the effects of Angelica sinensis, Millettia reticulata and Paeonia lactiflora on the efficacy of the product.

[0074] Control group 3: other methods are the same as those in Example 3, except that Angelica sinensis, Millettia spatholobi and Paeonia lactiflora are not used; the method of use is the same as that in Example 3.

[0075] Control group 4: other methods are the same as those in Example 3, except that red peony root is not used; the method of use is the same as that in Example 3.

[0076] Prior art group: Naoxintong (Shanxi Buchang Pharmaceutical Co., Ltd.) was administered intragastrically at a dosage of 2000 mg / kg / d.

[0077] Blank control group; distilled water was gavaged once a day, 2 ml each time.

[0078] Before the experiment, the rats were scored for neurological function, and the average value was 7.79. Then the rats were divided into 9 groups, and each experimental group treated one group of rats. 10 days was a course of treatment. At the end of the first, second and third courses of treatment, the rats were scored for neurological function again, and the average value was taken. The results are shown in Table 1.

[0079] The neurological function evaluation method used was the Garcia 18-point composite scoring method described in "Xj GJS K. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion inrats. Statistical validation. [J]. Stroke: A Journal of Cerebral Circulation, 1995, 26 (4).".

[0080] Table 1 Scoring questionnaire for each test group

[0081] First course of treatment First course of treatment First course of treatment Experimental Group 1 8.77 10.98 11.54 Experimental Group 2 8.86 11.16 11.98 Experimental Group 3 8.95 11.25 12.02 Control group 1 8.24 8.98 9.18 Control group 2 8.12 8.85 8.86 Control group 3 8.05 8.46 9.01 Control group 4 8.32 8.57 9.10 Existing Technology Group 9.02 11.52 12.31 Blank control group 7.52 7.14 6.86

[0082] As shown in Table 1, during the treatment, the neurological function score of the blank control group gradually decreased, indicating that the neurological function of the rats was increasingly impaired over time, while the neurological function scores of the experimental and control groups gradually increased, especially in experimental groups 1 to 3, whose improvement effects were basically the same as those of the drugs in the prior art group, and significantly better than those of the control group. This shows that only the prescription provided by the present invention can achieve the best therapeutic effect.

[0083] Experimental Example 2

[0084] 160 patients with acute stroke were selected, with an average age of 51.2 years, half male and half female, and were evenly divided into 8 groups, half male and half female;

[0085] The experimental group, control group, and prior art group were set up exactly as in Experimental Example 1;

[0086] Among them, the usage method of experimental groups 1 to 3 and control groups 1 to 4 is: take the obtained product once in the morning and evening every day, each time 35 ml.

[0087] The method of use of the prior art group refers to the instructions.

[0088] Each experimental group selected one of the groups for treatment, with 14 days as one course of treatment, and a total of 8 courses of treatment. Then the treatment status of the patients was judged according to the efficacy evaluation criteria (1995) formulated by the Fourth National Cerebrovascular Disease Conference, and the BI index of the patients before and after treatment was compared, and the average value was taken. The results are shown in Tables 2 and 3.

[0089] Table 2 Treatment effect questionnaire

[0090] Basically cured efficient No change deterioration Experimental Group 1 3 9 7 1 Experimental Group 2 4 10 6 0 Experimental Group 3 4 11 5 0 Control group 1 3 8 8 1 Control group 2 2 9 6 3 Control group 3 1 7 8 4 Control group 4 2 9 6 3 Existing Technology Group 6 11 3 0

[0091] Table 3 BI index change questionnaire

[0092] Before treatment After treatment Experimental Group 1 25.1 61.2 Experimental Group 2 25.0 62.3 Experimental Group 3 25.2 64.8 Control group 1 25.1 50.1 Control group 2 24.9 48.2 Control group 3 25.0 46.8 Control group 4 25.1 49.3 Existing Technology Group 25.2 67.4

[0093] It can be seen from the contents recorded in Table 3 that the therapeutic effect of the experimental group of the present invention is comparable to that of the drugs in the prior art, which indicates that the pharmaceutical composition obtained by the method of the present invention has an excellent technical effect of treating acute cerebral stroke.

[0094] From the data of the control group, it can be seen that if some of the components are discarded, the therapeutic effect of the composition will be significantly affected. In addition, the present invention's Semen Platycladi, Polygala, Angelica, Millettia and Paeonia lactiflora are used in combination. If only one of the components is added, the efficacy of the components cannot be fully exerted. From the data of control groups 1 to 4, it can be seen that only when two components are added at the same time, the best therapeutic effect can be achieved.

[0095] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating cerebral stroke, characterized in that: The invention is prepared from the following components in parts by weight: 20-26 parts of Gastrodia elata, 12-16 parts of Scolopendra subspinipes, 8-12 parts of Hawksbill turtle, 14-18 parts of Angelica sinensis, 10-16 parts of Millettia reticulata, 7-13 parts of Red Peony Root, 8-12 parts of Forsythia suspensa, 8-12 parts of Periostracum cicadae, 6-10 parts of Rehmannia glutinosa, 7-11 parts of Poria cocos, 7-11 parts of Eclipta prostrata, 4-8 parts of Semen Platycladi and 3-7 parts of Polygala tenuifolia.

2. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 1, characterized in that: The steps include: (1) Gastrodia elata, centipede, hawksbill turtle, Chinese angelica, Millettia reticulata, red peony root, forsythia suspensa, cicada shell, raw rehmannia root, tuckahoe, eclipta prostrata, cypress seed and polygala tenuifolia are mixed and ground to obtain material 1; (2) Mixing material 1 with water, performing ultrasonic extraction, and filtering to obtain a filtrate and a filter residue; (3) mixing the filter residue with water and boiling, and filtering to obtain an extract; (4) combining the filtrate with the extract to obtain a Chinese medicine composition for treating cerebral stroke.

3. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 2, characterized in that: The ground material in step (1) is passed through a 50-70 mesh sieve, and the material under the sieve is collected as material 1.

4. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 3, characterized in that: The mass ratio of the material 1 to water in step (2) is 1:4-6.

5. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 4, characterized in that: The temperature of the ultrasonic extraction in step (2) is 45-55°C.

6. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 5, characterized in that: The ultrasonic extraction time in step (2) is 40 to 50 minutes.

7. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 6, characterized in that: The frequency of the ultrasound in step (2) is 35-45 kHz.

8. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 7, characterized in that: The mass ratio of the filter residue to water in step (3) is 1:3-5.

9. The method for preparing a Chinese medicine composition for treating cerebral stroke according to claim 8, characterized in that: The decoction time in step (3) is 2 to 4 hours.