A preparation method of medical anti-adhesion material

Abstract

The invention discloses a preparation method of a medical anti-adhesion material, and the front side of the anti-adhesion intelligent single is a non-woven material, and its surface adds a biological anti-adhesion active hyaluronic acid material coating, and the back side is a PE anti-oil, waterproof, and anti-blood film, which is waterproof and breathable, without stimulation. Prepare a non-woven material with clean surface, dissolve the prepared double-bonded hyaluronic acid polymer of different masses in ultrapure water, form a polymer solution, and add 0.1%-1.0% of the photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution; The non-woven material after treatment is immersed in the hyaluronic acid solution containing an initiator, take out the non-woven material, place under ultraviolet lamp for cross-linking reaction 1-30 minutes, then use ultrapure water to clean the non-woven material three times, and finally dry at room temperature for 24 hours. The present invention prevents the single from adhering to the patient's skin lesions, avoids the secondary damage caused when the skin lesions are separated from the single, improves the recovery process of the patient's skin lesions, and increases comfort.

Description

Technical Field

[0001] The invention relates to a method for preparing an anti-adhesion material, and in particular to a method for preparing a medical anti-adhesion bed sheet material, which is suitable for patients with erosive exudative skin diseases, can effectively prevent the patient's skin lesions from adhering to the bed sheet, and is conducive to the healing of the patient's skin lesions. Background Art

[0002] The dermatology inpatient department admits a large number of patients with damaged skin barrier and erosion and exudation, including patients with bullous skin diseases, drug eruptions, herpes zoster, etc. During treatment, most of the patients' skin lesions are exposed. In order to protect the wound surface and prevent the clothes from being contaminated by exudate, it is usually necessary to add a middle sheet on the bed sheet. At present, there are two types of medical disposable middle sheets commonly used in hospitals. One is made of non-woven fabrics and plastic film, and the other is made of plastic film, non-woven fabrics, fluff pulp and polymer materials. The common disadvantage of the two types of middle sheets is that they have no anti-adhesion effect, which makes the skin lesions in the pressure area adhere to the middle sheet. The tearing during separation will cause secondary damage to the skin, seriously affecting the healing of the skin lesions. In addition, some patients do not turn over for a long time to avoid the adhesion of skin lesions to the middle sheet, making it difficult for the wound surface in the pressure area to heal. Some patients adopt passive postures such as sitting, which affects sleep and rest and causes physical exhaustion, affecting disease recovery. The new anti-adhesion midsole has a biological anti-adhesion active hyaluronic acid material coating added to the surface, which can prevent the wound from adhering to the midsole, overcoming a series of problems caused by adhesion between the midsole and the skin. Summary of the invention

[0003] The purpose of the present invention is to overcome the shortcomings of the traditional medical singlet during use, and to prevent the singlet from adhering to the patient's skin lesions by improving the material composition and surface structure of the original medical singlet, and to avoid secondary damage caused by the separation of the skin lesions from the singlet, and to help patients rest and sleep, improve the recovery process of the patient's skin lesions, and increase comfort. It is convenient for patients with wounds to use and can be widely promoted in China.

[0004] The front of the anti-adhesion smart mid-sole is made of non-woven fabric material, with a biological anti-adhesion active hyaluronic acid material coating added to its surface, and the back is made of PE oil-proof, waterproof and blood-proof film, which is waterproof, breathable and non-irritating.

[0005] The technical solution of the present invention is achieved in this way: the specific preparation steps are as follows:

[0006] First, the medical non-woven fabric material is ultrasonically cleaned in turn with water, ethanol, acetone and other solvents for 30 minutes to prepare a non-woven fabric material with a clean surface; the ratio of the medical non-woven fabric material to the solvent is 1: (5-100) by mass;

[0007] Prepare a hyaluronic acid aqueous solution with a mass volume fraction of 0.1%-2%, then add N,N-dimethylformamide DMF and water in a volume ratio of 1:3-2:3 to the hyaluronic acid solution, stir evenly, cool to 4 degrees Celsius, then add methacrylic anhydride and hyaluronic acid in a molar ratio of 1:1-3:1, use sodium hydroxide (0.5M) to adjust the pH value to 8.0-8.5, react at 4 degrees Celsius for 12-20 hours, centrifuge and freeze-dry for 12 hours to obtain double-bonded hyaluronic acid;

[0008] Dissolving the prepared double-bonded hyaluronic acid polymers of different masses into ultrapure water to form polymer solutions of different mass volume concentrations (0.1%-10%), and adding 0.1%-1.0% of a photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution;

[0009] The treated non-woven fabric material was immersed in the above-mentioned hyaluronic acid solution containing the initiator, and vacuumed for 30 minutes, with the vacuum degree maintained at 1 Pa. The non-woven fabric material was taken out and placed under a 365nm ultraviolet lamp for cross-linking reaction for 1-30 minutes. The non-woven fabric material was then washed three times with ultrapure water and finally dried at room temperature for 24 hours.

[0010] The present invention has the following significant effects

[0011] 1. Use the medical close-fitting anti-adhesion smart midsole, the wound surface will not stick to the midsole, avoiding the secondary damage caused by the adhesion of the midsole to the wound surface and shortening the healing time of the skin lesions.

[0012] 2. The use of anti-adhesion smart mid-sole meets the patient's requirements for the comfort of the mid-sole, allowing them to rest and sleep peacefully, which is conducive to recovery from the disease.

[0013] 3. The anti-adhesion smart mid-sheet can be cut and used at will, and used as an anti-adhesion pad. For example, it can be placed between the cuff and the skin lesion when measuring blood pressure, and the cuff of the sphygmomanometer is contaminated by exudate.

[0014] 4. It can absorb a small amount of exudate, has an auxiliary therapeutic effect, and promotes wound healing.

[0015] 5. In the future, the anti-adhesion intelligent middle single material can be used to make medical anti-adhesion gauze, which is suitable for postoperative wound care and bandaging.

[0016] 6. It can be used as anti-adhesion clothing for patients with skin erosion.

[0017] 7. The use cost is low (yuan / piece), which is conducive to clinical promotion.

[0018] 8. It is convenient for large-scale promotion in domestic dermatology, burns and surgery departments. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 Anti-adhesion intelligent mid-single structure diagram;

[0020] 1. Non-woven fabric 2. Coating 3. PE DETAILED DESCRIPTION

[0021] The present invention comprises the following specific steps:

[0022] 1) Pretreatment of non-woven fabric materials: First, the medical non-woven fabric material is ultrasonically cleaned with water for 30 minutes, ethanol for 30 minutes, and acetone for 30 minutes, and the treated non-woven fabric material is freeze-dried for 12 hours to obtain the pre-treated non-woven fabric material, which is stored in a dry environment for further use;

[0023] 2) Synthesis of photo-crosslinked hyaluronic acid coating material: 2 g of a certain mass of hyaluronic acid powder was dissolved in 100 mL of ultrapure water to prepare a hyaluronic acid aqueous solution with a mass volume fraction of 2%, and then N, N-dimethylformamide (DMF) (with a volume ratio of 1:3 to 2:3 with water) was added dropwise to the hyaluronic acid solution, stirred evenly, cooled to 4 degrees Celsius, and then methacrylic anhydride (with a molar ratio of 1:1 to 3:1 with hyaluronic acid) was added, and the pH value was adjusted to 8.0-8.5 with sodium hydroxide (0.5 M), reacted at 4 degrees Celsius for 20 hours, centrifuged and freeze-dried for 12 hours to obtain double-bonded hyaluronic acid;

[0024] 3) dissolving the prepared double-bonded hyaluronic acid polymers of different masses into ultrapure water to form polymer solutions of different mass volume concentrations (0.1%-10%), and adding 0.1%-1.0% of a photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution;

[0025] 4) Immerse the treated non-woven fabric material in the above-mentioned hyaluronic acid solution containing the initiator, evacuate for 30 minutes, maintain the vacuum degree at 1 Pa, take out the non-woven fabric material, place it under a 365nm ultraviolet lamp for cross-linking reaction for 1-30 minutes, then wash the non-woven fabric material three times with ultrapure water, and finally dry it at room temperature for 24 hours;

[0026] Example 1:

[0027] Step 1) ultrasonically cleaning the medical non-woven fabric material with water for 30 minutes, ultrasonically cleaning with ethanol for 30 minutes, and ultrasonically cleaning with acetone for 30 minutes, and freeze-drying the treated non-woven fabric material for 12 hours for later use;

[0028] Step 2) preparing a 2% hyaluronic acid aqueous solution by volume fraction, then dropping N,N-dimethylformamide (DMF) (with a volume ratio of 2:3 to water) into the hyaluronic acid solution, stirring evenly, cooling to 4 degrees Celsius, then adding methacrylic anhydride (with a molar ratio of 3:1 to hyaluronic acid), adjusting the pH value to 8.5 with sodium hydroxide (0.5M), reacting at 4 degrees Celsius for 20 hours, centrifuging and freeze-drying for 12 hours to obtain double-bonded hyaluronic acid;

[0029] Step 3) dissolving the double-bonded hyaluronic acid polymer in ultrapure water to prepare a polymer solution with a mass volume concentration of 2%, and adding 0.5% of a photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution;

[0030] Step 4) Immerse the treated non-woven fabric material in the above-mentioned hyaluronic acid solution containing the initiator, evacuate for 30 minutes, maintain the vacuum degree at 1 Pa, take out the non-woven fabric material, place it under a 365nm ultraviolet lamp for cross-linking reaction for 15 minutes, then use ultrapure water to wash the non-woven fabric material three times, and finally dry it at room temperature for 24 hours to obtain an anti-adhesion non-woven fabric material; the above prepared materials can also be used for disposable anti-adhesion clothing, anti-adhesion isolation pads, and anti-adhesion gauze.

[0031] Example 2:

[0032] Step 1) ultrasonically cleaning the medical non-woven fabric material with water for 30 minutes, ultrasonically cleaning with ethanol for 30 minutes, and ultrasonically cleaning with acetone for 30 minutes, and freeze-drying the treated non-woven fabric material for 12 hours for later use;

[0033] Step 2) preparing a 2% hyaluronic acid aqueous solution by volume fraction, then dropping N,N-dimethylformamide (DMF) (with a volume ratio of 2:3 to water) into the hyaluronic acid solution, stirring evenly, cooling to 4 degrees Celsius, then adding methacrylic anhydride (with a molar ratio of 3:1 to hyaluronic acid), adjusting the pH value to 8.5 with sodium hydroxide (0.5M), reacting at 4 degrees Celsius for 20 hours, centrifuging and freeze-drying for 12 hours to obtain double-bonded hyaluronic acid;

[0034] Step 3) dissolving the double-bonded hyaluronic acid polymer in ultrapure water to prepare a polymer solution with a mass volume concentration of 4%, and adding 0.6% of a photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution;

[0035] Step 4) Immerse the treated non-woven fabric material in the above-mentioned hyaluronic acid solution containing the initiator, evacuate for 30 minutes, maintain the vacuum degree at 1 Pa, take out the non-woven fabric material, place it under a 365nm ultraviolet lamp for cross-linking reaction for 15 minutes, then use ultrapure water to wash the non-woven fabric material three times, and finally dry it at room temperature for 24 hours to obtain an anti-adhesion non-woven fabric material; the above prepared materials can also be used for disposable anti-adhesion clothing, anti-adhesion isolation pads, and anti-adhesion gauze.

[0036] Example 3:

[0037] Step 1) ultrasonically cleaning the medical non-woven fabric material with water for 30 minutes, ultrasonically cleaning with ethanol for 30 minutes, and ultrasonically cleaning with acetone for 30 minutes, and freeze-drying the treated non-woven fabric material for 12 hours for later use;

[0038] Step 2) preparing a 2% hyaluronic acid aqueous solution by volume fraction, then dropping N,N-dimethylformamide (DMF) (with a volume ratio of 2:3 to water) into the hyaluronic acid solution, stirring evenly, cooling to 4 degrees Celsius, then adding methacrylic anhydride (with a molar ratio of 3:1 to hyaluronic acid), adjusting the pH value to 8.5 with sodium hydroxide (0.5M), reacting at 4 degrees Celsius for 20 hours, centrifuging and freeze-drying for 12 hours to obtain double-bonded hyaluronic acid;

[0039] Step 3) dissolving the double-bonded hyaluronic acid polymer in ultrapure water to prepare a polymer solution with a mass volume concentration of 6%, and adding 0.8% of a photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution;

[0040] Step 4) Immerse the treated non-woven fabric material in the above-mentioned hyaluronic acid solution containing the initiator, evacuate for 30 minutes, maintain the vacuum degree at 1 Pa, take out the non-woven fabric material, place it under a 365nm ultraviolet lamp for cross-linking reaction for 15 minutes, then use ultrapure water to wash the non-woven fabric material three times, and finally dry it at room temperature for 24 hours to obtain an anti-adhesion non-woven fabric material; the above prepared materials can also be used for disposable anti-adhesion clothing, anti-adhesion isolation pads, and anti-adhesion gauze.

Claims

1. A method for preparing a medical anti-adhesion material, characterized in that: First, the medical non-woven fabric material is ultrasonically cleaned in sequence with water, ethanol, and acetone solvents for 10-30 minutes to prepare a non-woven fabric material with a clean surface; the ratio of the medical non-woven fabric material to the solvent is 1:(5-100) by mass; A hyaluronic acid aqueous solution with a mass volume fraction of 0.1%-2% is prepared, and then N,N-dimethylformamide DMF solvent with a volume ratio of 1:3 to 2:3 with water is added dropwise to the hyaluronic acid solution, stirred evenly, cooled to 0-4 degrees Celsius, and then methacrylic anhydride is added, and the pH value of the solution is adjusted to 8.0-8.5 with sodium hydroxide, reacted at 4 degrees Celsius, centrifuged and freeze-dried to obtain double-bonded hyaluronic acid; Dissolving the prepared double-bonded hyaluronic acid in ultrapure water to form a double-bonded hyaluronic acid solution with a mass volume concentration of 0.1%-10%, and adding a photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to form a final mixed solution; The solvent-treated non-woven fabric material is immersed in the above-mentioned hyaluronic acid solution containing the photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate, and vacuumed for 30-50 minutes. The non-woven fabric material is taken out and placed under ultraviolet light for cross-linking reaction. The non-woven fabric material is then washed three times with ultrapure water and finally dried at room temperature to obtain a medical anti-adhesion material.

2. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The medical non-woven fabric material is ultrasonically cleaned using water, ethanol and acetone solvents for 10-30 minutes in sequence.

3. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The volume ratio of N,N-dimethylformamide DMF to water is 1:3-2:

3.

4. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The molar ratio of methacrylic anhydride to hyaluronic acid is 1:1-3:

1.

5. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The pH value of the solution is adjusted to 8.0-8.5 with sodium hydroxide; the solution is reacted at 4 degrees Celsius for 12-20 hours, and then freeze-dried for 12 hours after centrifugation.

6. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The mass volume concentration of the double-bonded hyaluronic acid solution is 0.1%-10%.

7. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The mass volume concentration of the photoinitiator phenyl (2,4,6-trimethylbenzoyl) lithium phosphate is 0.1%-1.0%.

8. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The solvent-treated nonwoven fabric is immersed in the hyaluronic acid solution containing the photoinitiator phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt. The vacuuming time is 30-50 minutes, and the vacuum degree is maintained at 1Pa.

9. The method for preparing the medical anti-adhesion material according to claim 1, characterized in that: The non-woven fabric material is placed under a 365nm ultraviolet lamp for a cross-linking reaction for 1-30 minutes and dried at room temperature for 24 hours.

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