Parameter control method, in vitro diagnostic device, and computer-readable storage medium

Abstract

Embodiments of the present invention disclose a parameter control method, an in vitro diagnostic device, and a computer-readable storage medium, relating to the field of data processing technology. The method includes obtaining initial parameters at a first preset time interval; comparing the initial parameters with target parameters to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and a first preset parameter table, wherein the first preset parameter table includes parameter values ​​corresponding to the comparison result, a pulse threshold, and a first mapping relationship between the parameter values ​​and the pulse threshold; and obtaining target particles based on the pulse threshold, wherein the target particles are particles that pass through the in vitro diagnostic device based on the pulse threshold. The present invention can effectively and accurately obtain target particles, avoiding misjudgments and misdiagnoses.

Description

Technical Field

[0001] The present invention relates to the field of data processing technology, and in particular to a parameter control method, in vitro diagnostic equipment, and a computer-readable storage medium. Background Art

[0002] With the rapid development of science and technology, continuous improvement and innovation, the speed of medical equipment replacement is also getting faster and faster. New medical equipment can also protect people's health. Take the blood cell analyzer, an indispensable in vitro diagnostic product (IVD) in hospitals, as an example. The red blood cell particles it obtains can provide a scientific basis for people's physical health. It can be said that the accuracy of the values ​​issued by IVD products is very important to both doctors and patients.

[0003] Current in vitro diagnostic products often exclude some red blood cell particles from normal red blood cell particles when acquiring target particles such as red blood cell particles, or record some unnecessary red blood cell particles as normal red blood cell particles. In other words, current in vitro diagnostic products are unable to effectively and accurately acquire target particles, and are prone to misjudgment and misdiagnosis, posing a safety hazard to patients' health. Summary of the Invention

[0004] In view of this, one of the objectives of this application is to provide a parameter control method, an in vitro diagnostic device and a computer-readable storage medium that can at least solve some of the above-mentioned technical problems.

[0005] In a first aspect, an embodiment of the present application provides a parameter control method, which is applied to an in vitro diagnostic device, wherein the initial parameters are obtained at a first preset time interval;

[0006] Comparing the initial parameter with the target parameter to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and a first preset parameter table, wherein the first preset parameter table includes parameter values ​​corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter values ​​and the pulse threshold;

[0007] Target particles are acquired according to the pulse threshold, where the target particles are particles that pass through the in vitro diagnostic device based on the pulse threshold.

[0008] In a possible implementation, after acquiring the initial parameters at the first preset time interval, the method further includes:

[0009] Dividing the initial parameters arranged in the order of acquisition time according to a preset number to obtain at least two first parameter sets, each first parameter set including the initial parameters and a counting process, wherein the time period corresponding to each first parameter set is a counting process of the in vitro diagnostic device;

[0010] The step of comparing the initial parameter with the target parameter to obtain a comparison result, and determining the pulse threshold of the in vitro diagnostic device according to the comparison result and a first preset parameter table, includes:

[0011] Calculating the mean of a preset number of initial parameters in each first parameter set, and comparing all the mean values ​​with the target parameters to obtain comparison results of all first parameter sets;

[0012] A set of pulse thresholds for each first parameter set is determined according to the comparison results of each first parameter set and the first preset parameter table, wherein the set of pulse thresholds includes a pulse threshold upper limit and a pulse threshold lower limit.

[0013] In a possible implementation, after dividing the initial parameters arranged in the order of acquisition time according to a preset number to obtain at least two first parameter sets, the method further includes:

[0014] Obtaining a device identification of the in vitro diagnostic device, and using the in vitro diagnostic device corresponding to the device identification in a preset database as a target device;

[0015] The step of comparing the initial parameter with the target parameter to obtain a comparison result, and determining the pulse threshold of the in vitro diagnostic device according to the comparison result and a first preset parameter table, includes:

[0016] Comparing each initial parameter in a second parameter set with the target parameter to obtain at least two comparison results, wherein the second parameter set is any first parameter set of the target device;

[0017] At least two sets of pulse thresholds for the target device are determined based on all comparison results in the second parameter set and the first preset parameter table, wherein the at least two sets of pulse thresholds are respectively used to obtain the target particles in different time periods during a counting process of the target device.

[0018] In one possible embodiment, the initial parameter includes at least one of a gas pressure and a liquid flow rate, wherein the gas pressure is the gas pressure generated when the in vitro monitoring device performs a pressure building operation, and the liquid flow rate is the flow rate of the liquid in which the target particles are located;

[0019] The acquiring of the initial parameters at the first preset time interval includes:

[0020] Obtaining the gas pressure according to a gas pressure sensor, and / or,

[0021] The liquid flow velocity is obtained according to a flow velocity sensor.

[0022] In a possible implementation, acquiring the initial parameters at the first preset time interval includes:

[0023] obtaining the ambient temperature of the in vitro diagnostic device at a second preset time interval;

[0024] The step of comparing the initial parameter with the target parameter to obtain a comparison result, and determining the pulse threshold of the in vitro diagnostic device according to the comparison result and a first preset parameter table, includes:

[0025] Calculate the temperature difference between the ambient temperature and the target temperature, and determine the pulse threshold of the in vitro diagnostic device based on the comparison result, the first preset parameter table, the temperature difference, and the second preset parameter table, wherein the second preset parameter table includes the temperature difference, the pulse threshold, and a mapping relationship between the temperature and the pulse threshold.

[0026] In a possible implementation, determining the pulse threshold of the in vitro diagnostic device according to the comparison result, the first preset parameter table, the temperature difference, and the second preset parameter table includes:

[0027] Determine a first value according to the comparison result and the first preset parameter table;

[0028] Multiplying the first value by a first weight coefficient to obtain a first target value;

[0029] determining a second value according to the temperature difference and the second preset parameter table;

[0030] Multiplying the second value by a second weight coefficient to obtain a second target value;

[0031] The pulse threshold is calculated according to the first target value and the second target value.

[0032] In a possible implementation, after acquiring the initial parameters at the first preset time interval, the method further includes:

[0033] Filtering the initial parameters to remove abnormal parameters in the initial parameters;

[0034] The step of comparing the initial parameter with the target parameter to obtain a comparison result, and determining the pulse threshold of the in vitro diagnostic device according to the comparison result and a first preset parameter table, includes:

[0035] The initial parameters after filtering are compared with the target parameters to obtain the comparison result, and the pulse threshold of the in vitro diagnostic device is determined according to the comparison result and the first preset parameter table.

[0036] In a possible implementation, the pulse threshold is a pulse width threshold, and the pulse width threshold includes an upper pulse width threshold and a lower pulse width threshold.

[0037] In a second aspect, an embodiment of the present application provides an in vitro diagnostic device, which includes a memory and a processor, wherein a computer program is stored in the memory, and when the computer program is executed by the processor, the parameter control method provided in the first aspect is implemented.

[0038] In a third aspect, an embodiment of the present application provides a computer-readable storage medium having a computer program stored thereon. When the computer program is executed by one or more processors, the parameter control method provided in the first aspect is implemented.

[0039] The parameter control method provided in the present application obtains initial parameters at a first preset time interval, then compares the initial parameters with the target parameters to obtain a comparison result, and determines the pulse threshold of the in vitro diagnostic device based on the comparison result and a first preset parameter table, wherein the first preset parameter table includes the parameter value corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter value and the pulse threshold. Finally, the target particles are obtained based on the pulse threshold. The target particles are particles that pass through the in vitro diagnostic device based on the pulse threshold. The target particles can be effectively and accurately obtained to avoid misjudgment and misdiagnosis. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. It should be understood that the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0041] Figure 1 A flow chart of a parameter control method provided in an embodiment of the present application;

[0042] Figure 2 A flow chart of a method for calculating a pulse threshold value included in a parameter control method provided in an embodiment of the present application;

[0043] Figure 3 This is a diagram of the internal structure of an in vitro diagnostic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0044] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0045] To make the objectives, technical solutions, and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Generally, the components of the embodiments of the present application described and shown in the drawings herein can be arranged and designed in various different configurations.

[0046] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. All other embodiments obtained by persons of ordinary skill in the art based on the embodiments in the present application without creative work are within the scope of protection of the present application.

[0047] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0048] In various embodiments of the present application, the expression "or" or "at least one of A or / and B" includes any or all combinations of the words listed simultaneously. For example, the expression "A or B" or "at least one of A or / and B" may include A, may include B, or may include both A and B.

[0049] In the description of this application, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the invented product is usually placed when in use. It is only for the convenience of describing this application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on this application.

[0050] In addition, the terms "first", "second", etc., if used, are merely used to distinguish and describe, and should not be understood as indicating or implying relative importance.

[0051] It should be noted that, in the absence of conflict, the features in the embodiments of this application can be combined with each other.

[0052] During their research, the applicant discovered that blood cell analyzers widely use the Coulter impedance method to detect red blood cells. The pulses generated by red blood cell particles passing through the jewel aperture of a blood cell analyzer have a certain width and height, which can be referred to as pulse width and pulse amplitude, respectively. It can be understood that pulse width can, under certain conditions, reflect the size of blood cell particles, and pulse width can be used to screen out red blood cell particles of specific requirements. However, pulse width is susceptible to changes due to factors such as liquid flow rate, the aperture of the jewel aperture of the blood cell analyzer, and the gas pressure in the negative pressure chamber. In such cases, conventional operating methods cannot effectively screen out red blood cell particles that meet specific requirements. Therefore, the parameter control method of this application is applicable to all IVD devices that can use pulse width to filter out target particles.

[0053] For details, please see Figure 1 , Figure 1 This is a flow chart of a parameter control method provided in an embodiment of the present application. The following describes each step of the method in detail.

[0054] S110: Acquire initial parameters at a first preset time interval.

[0055] In this embodiment, the initial parameters include operating parameters of the IVD device. Furthermore, the IVD device, also referred to as the in vitro diagnostic device in the following embodiments, can select corresponding operating parameters based on actual usage scenarios and actual needs, and includes at least one of a blood gas analyzer, a glycated hemoglobin analyzer, a rapid blood glucose analyzer, a hematology analyzer, and a blood cell analyzer. The first preset time interval includes 10ms, 1s, or 10s, and can be set or adjusted based on specific usage needs.

[0056] Optionally, the initial parameter includes at least one of a gas pressure and a liquid flow rate, wherein the gas pressure is the gas pressure generated when the in vitro monitoring device performs a pressure building operation, and the liquid flow rate is the flow rate of the liquid in which the target particles are located;

[0057] Acquiring initial parameters at a first preset time interval includes:

[0058] Obtaining gas pressure from a pressure sensor, and / or

[0059] The liquid flow rate is obtained according to the flow rate sensor.

[0060] Specifically, when an IVD device, such as a hematology analyzer, filters red blood cell particles, the analyzer generates a pulse signal as the red blood cell particles pass through the jewel aperture of the analyzer. This pulse signal is also susceptible to changes in gas pressure and liquid flow rate. In this embodiment, the initial parameters include at least one of gas pressure and liquid flow rate, which directly affect the pulse signal of the IVD device, such as the hematology analyzer.

[0061] Among them, IVD equipment such as a blood cell analyzer needs to complete pressure building during normal operation, and the corresponding gas pressure is generated through pressure building, that is, the gas pressure that needs to be obtained by the pressure sensor in this embodiment. IVD equipment such as a blood cell analyzer needs to limit the flow rate of the diluted blood when analyzing blood, and the flow rate of the diluted blood is also the liquid flow rate in this embodiment.

[0062] S120, comparing the initial parameters with the target parameters to obtain a comparison result, and determining the pulse threshold of the in vitro diagnostic device based on the comparison result and a first preset parameter table, wherein the first preset parameter table includes parameter values ​​corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter value and the pulse threshold.

[0063] In this embodiment, the comparison result can be the absolute value of the difference between the initial parameter and the target parameter. The target parameter and the initial parameter belong to the same type of parameters. The target parameter is pre-set and stored in the IVD device. The target parameter can be adjusted directly through the IVD device or through an intelligent control device connected to the IVD device.

[0064] If the initial parameter is gas pressure, for example, there are initial pressure and target pressure, the first preset parameter table includes pressure difference, pulse threshold and a first mapping relationship between pressure difference and pulse threshold, if the initial pressure is 2Pa, the target pressure is 1.5Pa, the difference between the initial pressure and the target pressure is 0.5Pa, the first preset parameter table includes pressure difference 0.1Pa, 0.2Pa, 0.3Pa, 0.4Pa, 0.5Pa, ..., 1Pa, pulse thresholds W1, W2, W3, W4, W5, ..., W 10 , and the first mapping relationship between the ten pressure differences and the ten pulse thresholds, such as 0.1 Pa corresponding to W1. It can also be understood that, considering that one of the parameters for determining the pulse threshold is the initial parameter, in other words, there is a corresponding relationship between the pulse parameter and the initial parameter.

[0065] After obtaining the initial parameters, this embodiment can quickly determine the pulse threshold corresponding to the initial parameters based on the target parameters and the first preset parameter table. The target particles in the following embodiments can be obtained based on the quickly determined pulse threshold, thereby improving the efficiency of obtaining the target particles.

[0066] In a possible implementation, the pulse threshold is a pulse width threshold, and the pulse width threshold includes an upper pulse width threshold limit and a lower pulse width threshold limit.

[0067] Specifically, the applicant discovered in their research that, under certain conditions, pulse width can reflect the size of cell particles, such as blood cell particles. The pulse width can be used to screen out red blood cell particles with specific requirements and obtain target particles. The upper and lower pulse width thresholds in this embodiment can accurately obtain target particles.

[0068] S130, acquiring target particles according to the pulse threshold, where the target particles are particles that pass through an in vitro diagnostic device based on the pulse threshold.

[0069] Considering that different particles, such as red blood cell particles, generate different pulse signals when passing through IVD equipment such as a hematology analyzer, this embodiment can specifically filter cell particles, such as red blood cell particles, using a predetermined pulse threshold to obtain target particles. This reduces or even avoids the situation where cell particles are mistakenly identified as target particles or are discarded as other cell particles, thereby obtaining precise target particles. Precise target particles facilitate accurate judgment by IVD equipment users, such as doctors, and can significantly reduce the probability of misjudgment and misdiagnosis, and even avoid misjudgment and misdiagnosis. The target particles obtained in this embodiment are actually target cell particles.

[0070] From the above analysis, it can be seen that the embodiment of the present application can compare the obtained initial parameters and target parameters, and then determine the pulse threshold corresponding to the initial parameters based on the comparison results and the first preset parameter table, wherein the first preset parameter table includes the parameter value corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter value and the pulse threshold. Finally, the particles are filtered according to the pulse threshold to obtain the target particles, and target particles of a certain size can be accurately obtained. The precise target particles are helpful for users of IVD equipment such as doctors to make accurate judgments, which can greatly reduce the probability of misjudgment and misdiagnosis, and even avoid misjudgment and misdiagnosis.

[0071] Considering that the working stability of different IVD devices may vary, the initial parameters of the red blood cell particle filtering process of IVD devices such as hematology analyzers may be unstable. The unstable initial parameters will directly affect the change of the pulse threshold, which may easily lead to the presence of a large number of particles in the acquired target particles that do not meet actual needs, affecting the accuracy and reliability of the judgment or diagnosis of IVD device users such as doctors.

[0072] In a possible implementation, after acquiring the initial parameters at the first preset time interval, the method further includes:

[0073] Dividing the initial parameters arranged in the order of acquisition time according to a preset number to obtain at least two first parameter sets, each first parameter set including the initial parameters and a counting process, wherein the time period corresponding to each first parameter set is a counting process of the in vitro diagnostic device;

[0074] Comparing the initial parameter with the target parameter to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and the first preset parameter table, including:

[0075] Calculating the mean of a preset number of initial parameters in each first parameter set, and comparing all the means with the target parameters respectively to obtain comparison results of all first parameter sets;

[0076] A set of pulse thresholds for each first parameter set is determined according to the comparison results of each first parameter set and the first preset parameter table, wherein the set of pulse thresholds includes a pulse threshold upper limit and a pulse threshold lower limit.

[0077] The above embodiment obtains the initial parameters according to the first preset time interval. Taking the first preset time interval of 2s as an example, if the amount of data of the initial parameters obtained is 10, the corresponding time required is 20s. If the preset number of divisions is 10, that is, every 10 initial parameters are grouped into a group to obtain multiple first parameter sets corresponding to this embodiment, a counting process is to obtain 10 and the time corresponding to the initial parameters. In other words, each first parameter set contains 10 initial parameters, and the 10 initial parameters in each first parameter set are sorted in the order of acquisition time.

[0078] It should be noted that the time period corresponding to obtaining each first parameter set is a counting process of the IVD device. For most IVD devices, during a counting process after completing the pressure buildup, their initial parameters such as gas pressure are relatively stable or constant. Therefore, the pulse threshold during a counting process is not easily affected, and the process of obtaining target particles is relatively stable, and the target particles can be obtained accurately and stably.

[0079] In this implementation, the mean of the first two or three initial parameters of the first parameter set can be compared with the target parameters to obtain a comparison result, and then a set of pulse thresholds of the first parameter set can be determined based on the comparison result and the first preset parameter table. This can improve the accuracy and speed of determining the pulse thresholds, thereby improving the efficiency and accuracy of acquiring target particles, which is beneficial for helping users of IVD equipment, such as doctors, to make quick and accurate judgments based on the obtained target particles.

[0080] In some embodiments, a comparison result can be obtained by comparing the first initial parameter in the first parameter set with the target parameter, and then a set of pulse thresholds for the first parameter set can be determined based on the comparison result and the first preset parameter table. This embodiment can further improve the speed of determining the pulse thresholds.

[0081] In accordance with the requirements of the production standards of some IVD devices, after completing the pressure building, these IVD devices may need to replenish the pressure because the negative pressure is consumed too quickly. That is, the air pump of these IVD devices needs to be started again to build pressure and establish the gas pressure near the target gas pressure. In this case, the internal gas pressure of these IVD devices fluctuates violently during a counting process, which can easily affect the pulse threshold and thus affect the stability and accuracy of obtaining target particles during a counting process of these IVD devices.

[0082] In a possible implementation, after dividing the initial parameters arranged in the order of acquisition time according to a preset number to obtain at least two first parameter sets, the method further includes:

[0083] Obtaining a device identifier of an in vitro diagnostic device, and using the in vitro diagnostic device corresponding to the device identifier in a preset database as a target device;

[0084] Comparing the initial parameter with the target parameter to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and the first preset parameter table, including:

[0085] Comparing each initial parameter in the second parameter set with the target parameter to obtain at least two comparison results, wherein the second parameter set is any first parameter set of the target device;

[0086] At least two sets of pulse thresholds of the target device are determined according to all comparison results in the second parameter set and the first preset parameter table, wherein the at least two sets of pulse thresholds are respectively used to obtain target particles in different time periods during a counting process of the target device.

[0087] Specifically, this embodiment uses certain IVD devices whose gas pressure is unstable during a single count as target devices. The preset database contains the device identifiers of the target devices. This embodiment uses the first parameter set of the target devices as the second parameter set. That is, the initial parameters in the second parameter set are also sorted by acquisition time. This embodiment compares each initial parameter in the second parameter set with the target parameter, and then determines the pulse threshold corresponding to each initial parameter based on all comparison results and the first preset parameter table. Based on all pulse thresholds, the target particles can be acquired during a single count of the target device.

[0088] For example, if the initial parameter is the initial gas pressure and the target parameter is the target gas pressure, each initial gas pressure in the second parameter set is compared with the target gas pressure. A set of pulse thresholds corresponding to each initial gas pressure is then determined based on each comparison result and the first preset parameter table. Each set of pulse thresholds can be determined at the moment the corresponding initial gas pressure is obtained, and target particles are directly acquired based on each set of pulse thresholds.

[0089] For example, if the second parameter set includes 10 initial gas pressures obtained at intervals of 2 seconds, according to the calculation in this embodiment, each initial gas pressure corresponds to a set of pulse thresholds. If the first initial gas pressure is obtained starting from the 2nd second, the second initial gas pressure is obtained correspondingly at the 4th second. At the 2nd second, the first initial gas pressure can be compared with the target gas pressure to obtain a first comparison result, and a set of pulse thresholds corresponding to the first initial gas pressure can be determined based on the first comparison result and the first preset parameter table. Between the 2nd and 4th seconds of the current counting process of the target device, target particles can be obtained based on the set of pulse thresholds corresponding to the first initial gas pressure. Correspondingly, between the 4th and 6th seconds of the current counting process of the target device, target particles can be obtained based on the set of pulse thresholds corresponding to the second initial gas pressure. Similarly, the target device can complete the acquisition of target particles during the current counting process based on the four sets of pulse thresholds.

[0090] The upper limit of the pulse threshold in each group of pulse thresholds is the upper limit of the pulse width threshold, and the lower limit of the pulse threshold in each group of pulse thresholds is the lower limit of the pulse width threshold.

[0091] This embodiment can effectively and accurately acquire target particles for some IVD devices with unstable initial parameters, avoiding the situation of miscounting of target particles, which is beneficial to improving the reliability and accuracy of judgment made by users of IVD devices such as doctors.

[0092] In a possible implementation, after acquiring the initial parameters at the first preset time interval, the method further includes:

[0093] Filter the initial parameters to remove abnormal parameters in the initial parameters;

[0094] Comparing the initial parameter with the target parameter to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and the first preset parameter table, including:

[0095] The initial parameters after filtering are compared with the target parameters to obtain a comparison result, and the pulse threshold of the in vitro diagnostic device is determined according to the comparison result and the first preset parameter table.

[0096] Specifically, filtering the initial parameters can filter out some abnormal initial parameters, which can improve the accuracy of determining the pulse threshold and help improve the accuracy and effectiveness of acquiring target particles. Optionally, the filtering of the initial parameters can be completed by a hampel filter.

[0097] Considering that the pulse threshold is also easily affected by temperature, in a possible implementation, obtaining the initial parameter at a first preset time interval includes:

[0098] obtaining the ambient temperature of the in vitro diagnostic device at a second preset time interval;

[0099] Comparing the initial parameter with the target parameter to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and the first preset parameter table, including:

[0100] The temperature difference between the ambient temperature and the target temperature is calculated, and the pulse threshold of the in vitro diagnostic device is determined based on the comparison result, the first preset parameter table, the temperature difference, and the second preset parameter table, wherein the second preset parameter table includes the temperature difference, the pulse threshold, and the mapping relationship between the temperature and the pulse threshold.

[0101] In this embodiment, considering that the frequency of changes in ambient temperature is not as high as the frequency of changes in gas pressure or liquid flow rate of the IVD device, the second preset time interval can be longer than the first preset time interval. In special circumstances where the frequency of ambient temperature changes is high, the second preset time interval can also be the same as the first preset time interval. The target temperature can also be set according to actual needs.

[0102] This embodiment takes into account that the pulse threshold is easily affected by temperature, introduces the ambient temperature and uses the ambient temperature as one of the parameters for determining the pulse threshold, thereby effectively ensuring the reliability and accuracy of the determined pulse threshold.

[0103] See Figure 2 , Figure 2 This is a flow chart of a method for calculating a pulse threshold value included in a parameter control method provided in an embodiment of the present application. In one possible implementation, determining the pulse threshold value of an in vitro diagnostic device based on a comparison result, a first preset parameter table, a temperature difference, and a second preset parameter table includes:

[0104] S210, determining a first value according to the comparison result and the first preset parameter table;

[0105] S220, multiplying the first value by a first weight coefficient to obtain a first target value;

[0106] S230, determining a second value according to the temperature difference and a second preset parameter table;

[0107] S240, multiplying the second value by a second weight coefficient to obtain a second target value;

[0108] S250: Calculate a pulse threshold value according to the first target value and the second target value.

[0109] Among them, the process of determining the first numerical value can refer to the process of comparing the initial parameters with the target parameters in the above embodiment to obtain a comparison result, and determining the pulse threshold according to the comparison result and the first preset parameter table, which will not be repeated here.

[0110] Optionally, the first and second weight coefficients can be determined by controlling variables, where the magnitude of the first weight coefficient reflects the influence of an initial parameter, such as gas pressure, on the pulse width, and the magnitude of the second weight coefficient reflects the influence of ambient temperature on the pulse width. For example, if it is detected that changes in temperature within a certain range cause a greater change in pulses, such as pulse width, when initial parameters, such as gas pressure, remain unchanged, than when changes in initial parameters, such as gas pressure, remain within a certain range while the temperature remains unchanged, then the first weight coefficient can be set smaller than the second weight coefficient.

[0111] Among them, the pulse threshold is calculated based on the first target value and the second target value, and the average of the sum of the first target value and the second target value can be used as the upper limit of the pulse width threshold, and the average of the absolute value of the difference between the first target value and the second target value can be used as the lower limit of the pulse width threshold.

[0112] This embodiment introduces ambient temperature and determines the pulse threshold by combining ambient temperature and initial parameters, thereby obtaining precise target particles. Precise target particles facilitate accurate judgment by users of IVD equipment, such as doctors, and can greatly reduce the probability of misjudgment and misdiagnosis, and even avoid misjudgment and misdiagnosis.

[0113] In summary, the embodiments of the present application can compare the obtained initial parameters with the target parameters, and then determine the pulse threshold corresponding to the initial parameters based on the comparison results and the first preset parameter table, wherein the first preset parameter table includes the parameter value corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter value and the pulse threshold. Finally, the particles are filtered according to the pulse threshold to obtain the target particles, and the target particles of a certain size can be accurately obtained. The ambient temperature is introduced, and the pulse threshold is determined by combining the ambient temperature and the initial parameters, so that accurate target particles can be obtained. The accurate target particles are helpful for users of IVD equipment such as doctors to make accurate judgments, which can greatly reduce the probability of misjudgment and misdiagnosis, and even avoid misjudgment and misdiagnosis.

[0114] This application also provides an in vitro diagnostic device, see Figure 3 , Figure 3The following is a diagram showing the internal structure of a computer device provided in an embodiment of the present application. The computer device includes a processor, a memory, and a network interface connected via a system bus. The memory includes a non-volatile storage medium and an internal memory. The non-volatile storage medium of the computer device stores an operating system and may also store a computer program. When the computer program is executed by the processor, the processor may implement the parameter control method applied to the computer device in the above embodiment. The internal memory may also store a computer program. When the computer program is executed by the processor, the processor may execute the parameter control method. It will be understood by those skilled in the art that Figure 3 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than shown in the figure, or combine certain components, or have a different component arrangement.

[0115] The embodiment of the present application further discloses a computer-readable storage medium, on which a computer program is stored. When the computer program is executed by a processor, the parameter control method in the method embodiment is implemented.

[0116] The in vitro diagnostic device and computer-readable storage medium provided in the present application obtain initial parameters at a first preset time interval, then compare the initial parameters with the target parameters to obtain a comparison result, and determine the pulse threshold of the in vitro diagnostic device based on the comparison result and a first preset parameter table, wherein the first preset parameter table includes the parameter value corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter value and the pulse threshold. Finally, target particles are obtained based on the pulse threshold. The target particles are particles that pass through the in vitro diagnostic device based on the pulse threshold. The target particles can be effectively and accurately obtained to avoid misjudgment and misdiagnosis.

[0117] Those skilled in the art will appreciate that all or part of the processes in the above-mentioned embodiments can be implemented by instructing the relevant hardware through a computer program. The program can be stored in a non-volatile computer-readable storage medium. When the program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM) or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

[0118] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

Claims

1. A parameter control method, characterized in that: Applied to in vitro diagnostic equipment, the method comprises: Acquiring initial parameters at a first preset time interval; Comparing the initial parameter with the target parameter to obtain a comparison result, and determining a pulse threshold of the in vitro diagnostic device based on the comparison result and a first preset parameter table, wherein the first preset parameter table includes parameter values ​​corresponding to the comparison result, the pulse threshold, and a first mapping relationship between the parameter values ​​and the pulse threshold; acquiring target particles according to the pulse threshold, wherein the target particles are particles passing through the in vitro diagnostic device based on the pulse threshold; After acquiring the initial parameters at the first preset time interval, the method further includes: Dividing the initial parameters arranged in the order of acquisition time according to a preset number to obtain at least two first parameter sets, each first parameter set including the initial parameters and a counting process, wherein the time period corresponding to each first parameter set is a counting process of the in vitro diagnostic device; The step of comparing the initial parameter with the target parameter to obtain a comparison result, and determining the pulse threshold of the in vitro diagnostic device according to the comparison result and a first preset parameter table, includes: Calculating the mean of a preset number of initial parameters in each first parameter set, and comparing all the mean values ​​with the target parameters to obtain comparison results of all first parameter sets; Determining a set of pulse thresholds for each first parameter set according to the comparison results of each first parameter set and the first preset parameter table, wherein the set of pulse thresholds includes an upper pulse threshold limit and a lower pulse threshold limit; After dividing the initial parameters arranged in the order of acquisition time according to the preset number to obtain at least two first parameter sets, the method further includes: Obtaining a device identification of the in vitro diagnostic device, and using the in vitro diagnostic device corresponding to the device identification in a preset database as a target device; Comparing each initial parameter in a second parameter set with the target parameter to obtain at least two comparison results, wherein the second parameter set is any first parameter set of the target device; At least two sets of pulse thresholds for the target device are determined based on all comparison results in the second parameter set and the first preset parameter table, wherein the at least two sets of pulse thresholds are respectively used to obtain the target particles in different time periods during a counting process of the target device.

2. The parameter control method according to claim 1, wherein: The initial parameter includes at least one of a gas pressure and a liquid flow rate, wherein the gas pressure is the gas pressure generated when the in vitro diagnostic device performs a pressure building operation, and the liquid flow rate is the flow rate of the liquid in which the target particles are located; The acquiring of the initial parameters at the first preset time interval includes: Obtaining the gas pressure according to a gas pressure sensor, and / or, The liquid flow velocity is obtained according to a flow velocity sensor.

3. The parameter control method according to claim 1, wherein: The acquiring of the initial parameters at the first preset time interval includes: obtaining the ambient temperature of the in vitro diagnostic device at a second preset time interval; Calculate the temperature difference between the ambient temperature and the target temperature, and determine the pulse threshold of the in vitro diagnostic device based on the comparison result, the first preset parameter table, the temperature difference, and the second preset parameter table, wherein the second preset parameter table includes the temperature difference, the pulse threshold, and a mapping relationship between the temperature and the pulse threshold.

4. The parameter control method according to claim 3, wherein: Determining the pulse threshold of the in vitro diagnostic device according to the comparison result, the first preset parameter table, the temperature difference, and the second preset parameter table includes: Determine a first value according to the comparison result and the first preset parameter table; Multiplying the first value by a first weight coefficient to obtain a first target value; determining a second value according to the temperature difference and the second preset parameter table; Multiplying the second value by a second weight coefficient to obtain a second target value; The pulse threshold is calculated according to the first target value and the second target value.

5. The parameter control method according to claim 1, wherein: After acquiring the initial parameters at the first preset time interval, the method further includes: Filtering the initial parameters to remove abnormal parameters in the initial parameters; The initial parameters after filtering are compared with the target parameters to obtain the comparison result, and the pulse threshold of the in vitro diagnostic device is determined according to the comparison result and the first preset parameter table.

6. The parameter control method according to claim 1, wherein: The pulse threshold is a pulse width threshold, and the pulse width threshold includes an upper pulse width threshold and a lower pulse width threshold.

7. An in vitro diagnostic device, characterized in that The in vitro diagnostic device includes a memory and a processor, wherein a computer program is stored in the memory, and when the computer program is executed by the processor, the parameter control method according to any one of claims 1 to 6 is implemented.

8. A computer-readable storage medium, characterized in that The computer-readable storage medium stores a computer program, which, when executed by one or more processors, implements the parameter control method according to any one of claims 1 to 6.

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