A composition for anti-allergic repair and use thereof

Abstract

The application discloses a kind of compositions for anti-allergic repair and application thereof.The anti-allergic composition includes the following components: 1-5 parts by weight of silk fibroin, 1-5 parts by weight of carrageenan, 40-200 parts by weight of water, 5-15 parts by weight of anti-allergic ingredients, 2-10 parts by weight of silymarin phosphate, 5-15 parts by weight of repair ingredients, 0.2-0.8 parts by weight of gamma-polyglutamic acid, and 0.2-1 parts by weight of polyethylene glycol-20000.The application also provides a preparation method thereof.Compared with the prior art, the anti-allergic repair composition prepared by the application can reduce the permeability of capillary vessels, has good inhibition of hyaluronidase, and has good anti-allergic repair effect.The anti-allergic repair composition prepared by the application can also be applied in face masks, face creams and dressings.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a composition for anti-allergic repair and application thereof. BACKGROUND

[0002] In the medical field, skin allergic reaction is called hypersensitivity reaction, which refers to abnormal specific immune response mainly with physiological function disorder or tissue cell damage when the body is stimulated by certain specific antigens. The main pathological changes of skin allergic reaction are increased permeability, skin capillary dilation, tissue degeneration and necrosis, etc., which can cause symptoms such as itching, redness, swelling and desquamation. The whole process of allergic reaction can be roughly divided into three stages: sensitization, activation and effect. After the external allergen enters the body of allergic constitution, the specific B cells of the allergen are induced to produce antibodies, and the produced antibodies are combined with the surface of basophils and mast cells. Once combined, the body is in a state of sensitization, and if the body does not contact the allergen for a long time, the sensitization state of the body will slowly disappear, which generally lasts for several months or even longer. When the external allergen enters the body again, it will specifically combine with the surface antibodies of the two specific cells (basophils and mast cells) to activate the two cells, leading to degranulation, and finally causing allergic symptoms in the body. This process is called the activation stage of allergic reaction. After the activation stage of allergic reaction, the effect stage is entered, that is, the process of the released allergic mediators acting on the body. The effect stage often causes allergic reactions, which can occur locally or systemically.

[0003] Skin allergic reaction has a great impact on daily life. During skin allergic reaction, symptoms such as redness, swelling and papules occur, which have a certain impact on appearance. In addition, the skin is dry, red, swollen, painful and itchy, which seriously affects normal work and study. Due to the increasing number of allergic people, the further development of anti-allergic research is promoted. The anti-allergic research of skin is mainly for drugs and natural compounds, which can treat the skin according to the mechanism of allergy. Inhibition of the release of allergic mediators is mainly based on antihistamine drugs, but long-term use of antihistamine drugs can easily cause serious side effects.

[0004] The application patent with the application number 201410005713.7 discloses a kind of repair skin barrier function anti-allergic moisturizing composition and its external preparation, the repair skin barrier function anti-allergic moisturizing nutrient composition main component includes repair skin barrier function component, natural extract anti-allergic antipruritic component, moisturizing nutrient component, wherein repair skin barrier function component is: 3-10 weight parts grape seed extract, 1-5 weight parts nicotinamide;Natural extract anti-allergic antipruritic component is: 0.5-1 weight parts dipotassium glycyrrhizinate, 1-2 weight parts chamomile extract, 0.25-1 weight parts sophora flavescens extract;Moisturizing nutrient component is: 1-3 weight parts dimethicone, 3-5 weight parts glycerol, 4-8 weight parts propylene glycol, 4-8 weight parts butanediol, 2-5 weight parts sodium hyaluronate, 0.5-2 weight parts allantoin;Nicotinamide and grape seed extract OPCs have very good synergistic effect, nicotinamide and OPCs combined processing significantly enhances the ability of skin keratinocytes to secrete ceramide, free fatty acid and hyaluronic acid, etc., repair skin surface barrier, reduce water loss through epidermis, keep skin moist and healthy state, enhance the resistance of skin to external stimulation, reduce the sensitivity of skin.And grape seed extract OPCs is the strongest natural antioxidant in the world at present, OPCs can resist excess free radicals caused by environmental stimuli, reduce the damage of external factors such as ultraviolet rays on skin, promote skin dermal collagen proliferation, angiogenesis, repair skin dermal deep damage, wrinkle, remove color spots, maintain healthy and young state of skin;Sophora flavescens extract active ingredient sophoramine has anti-allergic effect, inhibits the production of TSLP, eosinophil chemotactic factor and other pro-allergic factors, uses dipotassium glycyrrhizinate to prevent the release of histamine and other inflammatory factors, uses chamomile extract active ingredient apigenin to inhibit the release of 5-hydroxytryptamine, and cooperates to improve the sensitive and itchy state of skin, and breaks the vicious cycle of "skin barrier dysfunction-itching-inflammation".The component combination is made into external emulsion dosage form, which has the functions of repairing skin barrier function, anti-allergic and moisturizing nutrition.However, the composition may have the problem of long treatment time for improving facial skin allergy. SUMMARY

[0005] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present application is to provide a composition which can reduce capillary permeability, has strong inhibition on hyaluronidase, and has good anti-allergic repair effect in a short time.

[0006] In order to achieve the above object, the present application provides a kind of composition for anti-allergic repair, it is characterized in that, including the following components: 1-5 parts by weight of silk fibroin, 1-5 parts by weight of carrageenan, 40-200 parts by weight of water, 5-15 parts by weight of anti-allergic component, 2-10 parts by weight of silymarin phosphate, 5-15 parts by weight of repair component, 0.2-0.8 parts by weight of gamma-polyglutamic acid, 0.2-1 parts by weight of polyethylene glycol-20000.

[0007] Preferably, the preparation method of the anti-allergic component is as follows:

[0008] Step 1, mix Sophora flavescens powder, Ophiopogon japonicus powder, Scutellaria baicalensis powder, Herba Portulacae powder, Radix Glycyrrhizae powder, Radix Lithospermi powder, Houttuynia cordata powder, then add water, stir at 300-500 rpm for 45-90 minutes at 85-100 ℃, cool to 40-50 ℃, then add Cactus powder, stir at 300-500 rpm for 45-90 minutes at 40-50 ℃, then cool to 20-30 ℃, filter with 90-150 mesh filter screen, collect the filtrate, then centrifuge at 5000-8000 rpm for 30-60 minutes, collect the supernatant, then filter the supernatant with 0.45-0.8 micron filter membrane, collect the filtrate, heat to concentrate to 75-90% volume reduction at 40-55 ℃, then freeze-dry to obtain the anti-allergic extract;

[0009] Step 2, mix the anti-allergic extract prepared in step 1 with water, stir at 300-500 rpm for 20-40 minutes, adjust the pH to 8.6-9.2 with 5-10 mol / L sodium hydroxide aqueous solution, then add acetic anhydride dropwise at a speed of 0.06-1.2 mL / min under stirring at 300-500 rpm, adjust the pH to 8-8.5 with 5-10 mol / L sodium hydroxide aqueous solution every 10 minutes, then continue stirring at 300-500 rpm at 50-70 ℃ for 2-5 hours, then adjust the pH to 6.8-7.1 with 5-10 mol / L hydrochloric acid solution, dialyze in water for 2-4 days, then freeze-dry to obtain the anti-allergic component.

[0010] Preferably, the mass ratio of Sophora flavescens powder, Ophiopogon japonicus powder, Scutellaria baicalensis powder, Herba Portulacae powder, Radix Glycyrrhizae powder, Radix Lithospermi powder, Houttuynia cordata powder, water and Cactus powder in step 1 is 5-20:90-160:20-50:10-30:15-40:20-50:10-30:200-1000:50-120.

[0011] Preferably, the mass and volume ratio of the anti-allergic extract prepared in step 1 to water in step 2 is 10-30 g:1000-2500 mL.

[0012] Preferably, the anti-allergic extract prepared in step 1 is mixed with acetic anhydride in a mass and volume ratio of 10-30 g:300-900 mL.

[0013] Preferably, the dialysis has a molecular weight cut-off of 10-20 kD.

[0014] Preferably, the repair component comprises the following components: 10-25 parts by weight of squalane, 5-15 parts by weight of glycine, 5-15 parts by weight of nicotinamide, 10-25 parts by weight of Gotu Kola extract, 5-15 parts by weight of fibronectin, and 5-20 parts by weight of oat beta-glucan.

[0015] Preferably, the preparation method of the phosphonated silymarin is as follows:

[0016] Silymarin and acetone are mixed and ultrasonicated for 5-15 minutes, N,N-diisopropylethylamine and 4-dimethylaminopyridine are then added, and a 0.2-0.3 mmol / mL phosphite solution in carbon tetrachloride is added dropwise at a rate of 2-5 mL / min in a water bath at -2-2°C, followed by stirring at 300-500 rpm for 20-25 hours at 18-25°C, and then dried at 50-60 steam °C for 1-4 hours, dissolved in 25-45°C ethyl acetate, washed with water and saturated brine solution for 2-4 times, then dried with anhydrous sodium sulfate, and then dried at 45-60 steam °C to obtain phosphonated silymarin.

[0017] Preferably, the mass and volume ratio of silymarin to acetone is 23-26 g:1000-3000 mL.

[0018] Preferably, the ultrasonic power is 150-300 W.

[0019] Preferably, the mass ratio of silymarin, N,N-diisopropylethylamine, and 4-dimethylaminopyridine is 23-26:23-28:0.3-1.

[0020] Preferably, the mass and volume ratio of silymarin to phosphite solution in carbon tetrachloride is 23-26 g:100-300 mL.

[0021] The preparation method of the anti-allergic repair composition is as follows:

[0022] Silk fibroin and carrageenan are added to water, stirred at 300-500 rpm for 10-30 minutes at 85-95°C, then the anti-allergic component and phosphonated silymarin are added, and stirring is continued at 300-500 rpm for 10-30 minutes, then the repair component, gamma-polyglutamic acid, and polyethylene glycol-20000 are added, and stirring is continued at 300-500 rpm for 5-15 minutes to obtain the anti-allergic repair composition.

[0023] The anti-allergic repair composition prepared by the present application is directly added into a mask, a cream, and a dressing for application.

[0024] The anti-allergic component, the repair component, and the phosphonated silymarin are loaded in a gel with silk fibroin, carrageenan, and gamma-polyglutamic acid as base materials to obtain the anti-allergic repair composition. The anti-allergic repair effect of the prepared anti-allergic repair composition is good. The anti-allergic component is the water extract of Sophora flavescens powder, Ophiopogon japonicus powder, Scutellaria baicalensis powder, Portulaca oleracea powder, Glycyrrhiza uralensis powder, Lithospermum erythrorhizon powder, Houttuynia cordata powder, and Cactus powder prepared by acetylation reaction, which enhances the inhibition of the anti-allergic component on hyaluronidase. The repair component is a mixture of squalane, glycine, nicotinamide, Gynostemma pentaphyllum extract, fibronectin, and oat beta-glucan, which has good moisturizing effect, can enhance the moisturizing capacity of the skin, has anti-inflammatory and soothing effects on the skin, and can promote skin repair. The phosphonated silymarin is obtained by phosphonating silymarin with phosphite, which can increase the liposolubility of silymarin, improve the skin absorption of the anti-allergic repair composition, and enhance the anti-allergic repair effect of the anti-allergic repair composition. Silk fibroin, carrageenan, and gamma-polyglutamic acid are used as gel base materials. Silk fibroin has excellent tissue adhesion and good skin compatibility, which can enhance the effect of active substances in the anti-allergic repair composition on the skin. The hydrogel of gamma-polyglutamic acid has a three-dimensional network structure, good water absorption, and slow release capacity, which can improve the moisturizing performance of the anti-allergic repair composition. Gamma-polyglutamic acid also has antioxidant effect and good hyaluronidase inhibition activity.

[0025] Compared with the prior art, the present application has the following advantages: 1) The addition of the anti-allergic component enhances the inhibition of the anti-allergic component on hyaluronidase and improves the anti-allergic repair effect of the anti-allergic repair composition; 2) The phosphonated silymarin enhances the skin absorption of the anti-allergic repair composition and improves the anti-allergic repair effect of the anti-allergic repair composition; 3) Silk fibroin and gamma-polyglutamic acid are used as gel base materials, and the combination of silk fibroin and gamma-polyglutamic acid further improves the moisturizing and anti-inflammatory effect of the anti-allergic repair composition and enhances the anti-allergic repair effect. DETAILED DESCRIPTION

[0026] Part of raw material sources in examples and comparative examples:

[0027] Sophora flavescens powder, Ophiopogon japonicus powder, Scutellaria baicalensis powder, Portulaca oleracea powder, Glycyrrhiza uralensis powder, Lithospermum erythrorhizon powder, Houttuynia cordata powder, and Cactus powder are all prepared by drying, crushing, grinding, and sieving through an 80-mesh sieve from dried Sophora flavescens, Ophiopogon japonicus, Scutellaria baicalensis, Portulaca oleracea, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Houttuynia cordata, and Cactus.

[0028] Silymarin: CAS No.: 65666-07-1.

[0029] Centella asiatica extract: Product specification: water extraction, 20:1 (mass ratio of raw material to extract).

[0030] Oat beta-glucan: content specification: 98%, particle size: 80 mesh.

[0031] Example 1

[0032] A preparation method of the composition for anti-allergic repair is as follows:

[0033] 1 g of silk fibroin and 1 g of carrageenan were added to 40 mL of water, stirred at 400 rpm at 90°C for 20 minutes, then 10 g of anti-allergic ingredients, 8 g of silymarin phosphate, 10 g of repair ingredients, 0.5 g of gamma-polyglutamic acid, and 0.5 g of polyethylene glycol-20000 were added, and stirred at 400 rpm for 10 minutes to obtain the composition for anti-allergic repair.

[0034] A preparation method of the anti-allergic ingredients is as follows:

[0035] Step 1, 100 g of Sophora flavescens powder, 1300 g of Ophiopogon japonicus powder, 300 g of Scutellaria baicalensis powder, 200 g of Portulaca oleracea powder, 300 g of Glycyrrhiza uralensis powder, 300 g of Arnebia powder, and 200 g of Houttuynia cordata powder were mixed, 8000 g of water was added, and stirred at 400 rpm at 90°C for 60 minutes, then cooled to 45°C, 700 g of cactus powder was added, and stirred at 400 rpm at 45°C for 60 minutes, then cooled to 25°C, filtered with a 100 mesh filter screen, collected the filtrate, then centrifuged at 6000 rpm for 45 minutes, collected the supernatant, then filtered the supernatant with a 0.8 micron filter membrane, collected the filtrate, heated and concentrated to 80% volume reduction at 45°C, then freeze-dried to obtain anti-allergic extract;

[0036] Step 2, 20 g of the anti-allergic extract prepared in Step 1, and 1500 mL of water were mixed, stirred at 400 rpm for 30 minutes, the pH was adjusted to 9 with 8 mol / L sodium hydroxide aqueous solution, then 600 mL of acetic anhydride was added dropwise at a speed of 1 mL / min under the condition of stirring at 400 rpm, the pH was adjusted to 8.3 with 8 mol / L sodium hydroxide aqueous solution every 10 minutes, then continued to stir at 400 rpm at 60°C for 3 hours, then the pH was adjusted to 7 with 8 mol / L hydrochloric acid, and dialyzed in water for 3 days with a molecular weight cut-off of 12 kD, then freeze-dried to obtain the anti-allergic ingredients.

[0037] A preparation method of the silymarin phosphate is as follows:

[0038] Silymarin 24.1 g, 1500 mL of acetone were mixed by ultrasonic for 10 minutes at 250 W, and then 25.9 g of N,N-diisopropyl ethylamine, 0.6 g of 4-dimethylamino pyridine were added, 200 mL of 0.25 mmol / mL phosphite in carbon tetrachloride was added dropwise at 3 mL / min at 0°C water bath, and then stirred at 400 rpm for 21 hours at 20°C, followed by evaporation at 55°C for 2.5 hours, dissolved with 35°C ethyl acetate and washed with water and saturated brine solution for 3 times, then dried with anhydrous sodium sulfate, and then dried at 55°C to obtain phosphonated silymarin.

[0039] The repair component is a mixture of 15 g of squalane, 10 g of glycine, 10 g of nicotinamide, 20 g of Gotu Kola extract, 10 g of fibronectin, and 15 g of oat beta-glucan.

[0040] Comparative Example 1

[0041] A method for preparing a composition for anti-allergic repair is as follows:

[0042] 1 g of silk fibroin and 1 g of carrageenan were added to 40 mL of water, stirred at 400 rpm for 20 minutes at 90°C, and then 10 g of an anti-allergic component and 8 g of silymarin were added, and stirring was continued at 400 rpm for 20 minutes, and then 10 g of a repair component, 0.5 g of γ-polyglutamic acid, and 0.5 g of polyethylene glycol-20000 were added, and stirring was continued at 400 rpm for 10 minutes to obtain a composition for anti-allergic repair.

[0043] The anti-allergic component was prepared in the same manner as in Example 1.

[0044] The repair component was prepared in the same manner as in Example 1.

[0045] Comparative Example 2

[0046] A method for preparing a composition for anti-allergic repair is as follows:

[0047] 1 g of carrageenan was added to 40 mL of water, stirred at 400 rpm for 20 minutes at 90°C, and then 10 g of an anti-allergic component and 8 g of phosphonated silymarin were added, and stirring was continued at 400 rpm for 20 minutes, and then 10 g of a repair component, 1.5 g of γ-polyglutamic acid, and 0.5 g of polyethylene glycol-20000 were added, and stirring was continued at 400 rpm for 10 minutes to obtain a composition for anti-allergic repair.

[0048] The anti-allergic component was prepared in the same manner as in Example 1.

[0049] The phosphonated silymarin was prepared in the same manner as in Example 1.

[0050] The repair component is the same as that of Example 1.

[0051] Comparative Example 3

[0052] A preparation method of the composition for anti-allergic repair is as follows:

[0053] 1.5 g of silk fibroin and 1 g of carrageenan are added to 40 mL of water, stirred at 400 rpm at 90℃ for 20 minutes, then 10 g of the anti-allergic component, 8 g of the phosphatidyl silymarin are added, and stirring is continued at 400 rpm for 20 minutes, followed by the addition of 10 g of the repair component, 0.5 g of polyethylene glycol-20000, and stirring at 400 rpm for 10 minutes, to obtain the composition for anti-allergic repair.

[0054] The preparation method of the anti-allergic component is the same as that of Example 1.

[0055] The preparation method of the phosphatidyl silymarin is the same as that of Example 1.

[0056] The repair component is the same as that of Example 1.

[0057] Test Example 1

[0058] Permeability test:

[0059] A capillary permeability test is performed on the composition for anti-allergic repair of the present application according to a doctoral dissertation (Preparation process, efficacy and action pathway of anti-allergic plant extract, Wang Ling, Northeast Agricultural University, June 2015), and the steps are as follows: 1. 30 mice are randomly divided into 5 groups, 6 mice in each group, namely test 1, test 2, test 3, test 4, and a blank control group, corresponding to the composition for anti-allergic repair prepared in Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 3, and distilled water, respectively; 2. The experimental area on the back of the mice is depilated, and the depilation area is 1.5×1.5 cm 2 After 3 hours of application, 0.2wt% Evans blue saline solution is injected into the tail vein of the mice at 0.1 mL / 10 g of mouse weight, then 0.2 mL of 0.6wt% ice acetic acid aqueous solution is injected into the abdominal cavity of the mice, and after 20 minutes, the mice are sacrificed by cervical dislocation, the abdominal cavity of the mice is cut open, and the abdominal cavity is washed twice with 4 mL of saline, and the washing liquid is combined. Centrifugation is performed at 4000 rpm for 10 minutes, the supernatant is taken, and the absorbance value is measured at 590 nm wavelength by ultraviolet spectrophotometry. The percentage of dye exudation inhibition is calculated according to Formula 1, and the results are shown in Table 1:

[0060]

[0061] Wherein: A0 is the absorbance of the blank control group; A1 is the absorbance of the test group.

[0062] Test Example 2

[0063] Hyaluronidase in vitro inhibition test:

[0064] The hyaluronidase in vitro inhibition test of the composition for anti-allergic repair of the present application is carried out with reference to the doctoral dissertation (Preparation Process, Efficacy and Action Pathway of Anti-allergic and Anti-itching Plant Combination Extract, Wang Ling, Northeast Agricultural University, June 2015), and the steps are as follows: 1. Take 12 mg of the composition for anti-allergic repair prepared in the present application, dilute with water to a concentration of 6 mg / mL, and obtain a test sample; 2. Mix 1155 μL of glacial acetic acid with water to make up to 100 mL, then take 4.8 mL as solution A, dissolve 2.72 g of sodium acetate crystals in water and make up to 100 mL, take 45.2 mL as solution B, then mix solution A and solution B, and make up to 100 mL with water to obtain an acetic acid buffer solution, then use the acetic acid buffer solution as a solvent to prepare a hyaluronidase solution with a concentration of 1250 μg / mL and a sodium hyaluronate solution with a concentration of 0.5 mg / mL; 3. Dissolve 0.8 g of p-dimethylaminobenzaldehyde in 15 mL of concentrated hydrochloric acid and 15 mL of anhydrous ethanol to obtain the Ehrlich reagent; dissolve 3.5 mL of acetylacetone in 50 mL of a 1 mol / L sodium carbonate solution to obtain an acetylacetone solution (freshly prepared); 4. Add 0.1 mL of a 0.25 mol / L calcium chloride solution and 0.5 mL of the hyaluronidase solution to a test tube, incubate at 37°C for 20 minutes, then add 0.5 mL of the test sample, continue to incubate at 37°C for 20 minutes, add 0.5 mL of the sodium hyaluronate solution, incubate at 37°C for 30 minutes, then stand at 25°C for 5 minutes, add 0.1 mL of a 0.4 mol / L sodium hydroxide aqueous solution and 0.5 mL of the acetylacetone solution, heat in a boiling water bath for 15 minutes, immediately place in an ice water bath for 5 minutes, then add 1 mL of the Ehrlich reagent and 3 mL of anhydrous ethanol, stand for 20 minutes for color development, and use a UV spectrophotometer to scan the absorbance in the wavelength range of 450-700 nm, then substitute the measured absorbance value into formula 2 to calculate the hyaluronidase inhibition rate, and the results are shown in Table 1.

[0065]

[0066] Wherein: A is the absorbance value of the control solution (use the acetic acid buffer solution instead of the sample solution); B is the absorbance value of the blank control solution (use the acetic acid buffer solution instead of the sample solution and the enzyme solution); C is the absorbance value of the test sample solution; D is the absorbance value of the test sample blank solution (use the acetic acid buffer solution instead of the enzyme solution).

[0067] Test Example 3

[0068] Anti-allergy repair test:

[0069] Select 24 volunteers who are in the face skin allergy (the face skin has itching, has red rash, has skin problems such as peeling) and the age is between 20-30 years old, the ratio of male and female is 1:1, randomly divided into 4 groups, 6 people in each group, the composition for anti-allergy repair prepared by the application is diluted 5 times with pure water, applied to the allergic place, once a day after washing the face in the morning and evening, continuously applied for 7 days, observe the condition of the face allergic place after 7 days and record, the results are shown in Table 1.

[0070] Table 1 test results

[0071]

[0072] From the results of comparative example 1 and comparative examples 1-3, the anti-allergy repair performance of example 1 is better than that of comparative examples 1-3, which may be that the phosphoric acid esterized silymarin improves the absorption of the composition for anti-allergy repair by the skin, and the anti-allergy repair effect of the composition for anti-allergy repair is enhanced; the silk fibroin has excellent tissue adhesion and good skin compatibility, and can enhance the effect of active substances in the composition for anti-allergy repair on the skin; the hydrogel of γ-polyglutamic acid has a three-dimensional network structure of polymerization, has good water absorption and slow release capacity, and can improve the moisturizing performance of the composition for anti-allergy repair, and γ-polyglutamic acid also has antioxidant effect and good hyaluronidase inhibition activity, the compounding of silk fibroin and γ-polyglutamic acid further improves the anti-allergy repair effect of the composition for anti-allergy repair.

Claims

1. A composition for anti-allergic repair, characterized in that, The invention comprises the following components: 1 to 5 parts by weight of silk fibroin, 1 to 5 parts by weight of carrageenan, 40 to 200 parts by weight of water, 5 to 15 parts by weight of an anti-allergic component, 2 to 10 parts by weight of phosphated silymarin, 5 to 15 parts by weight of a repair component, 0.2 to 0.8 parts by weight of gamma-polyglutamic acid, and 0.2 to 1 parts by weight of polyethylene glycol-20000; The preparation method of the anti-allergic component is as follows: Step 1: Mix sophora flavescens powder, ophiopogon powder, scutellaria baicalensis powder, purslane powder, licorice powder, lithospermum officinale powder, and houttuynia cordata powder, then add water, stir at 85-100° C. for 45-90 minutes, cool to 40-50° C., add cactus powder, stir at 40-50° C. for 45-90 minutes, then cool to 20-30° C., filter with a filter, collect the filtrate, centrifuge, collect the supernatant, filter, collect the filtrate, heat and concentrate at 40-55° C., and then freeze-dry to obtain an anti-allergic extract; Step 2: Mix the antiallergic extract prepared in step 1 with water, stir, adjust the pH to 8.6-9.2 with a sodium hydroxide aqueous solution, then add acetic anhydride dropwise while stirring, adjust the pH to 8-8.5 with a sodium hydroxide aqueous solution every 10 minutes, continue stirring at 50-70° C. for 2-5 hours, then adjust the pH to 6.8-7.1 with a hydrochloric acid solution, dialyze in water, and then freeze-dry to obtain an antiallergic component; The preparation method of the phosphated silymarin is as follows: Silymarin and acetone are mixed and ultrasonicated, and then N,N-diisopropylethylamine and 4-dimethylaminopyridine are added. In a water bath at -2 to 2°C, a carbon tetrachloride solution of phosphite is added dropwise. The mixture is then stirred at 18 to 25°C for 20 to 25 hours, and then evaporated at 50 to 60°C for 1 to 4 hours. The mixture is dissolved in ethyl acetate at 25 to 45°C, washed and extracted with water and a saturated saline solution, and then dried over anhydrous sodium sulfate and evaporated to dryness to obtain phosphated silymarin. The repairing ingredients include the following components: squalane, glycine, niacinamide, Centella asiatica extract, fibronectin, and oat beta-glucan.

2. The composition for anti-allergic repair according to claim 1, characterized in that: The mass ratio of the sophora flavescens powder, ophiopogon powder, scutellaria baicalensis powder, purslane powder, liquorice powder, lithospermum erythrorhizon powder, houttuynia cordata powder, water, and cactus powder in step 1 is 5-20:90-160:20-50:10-30:15-40:20-50:10-30:200-1000:50-120.

3. The composition for anti-allergic repair according to claim 1, characterized in that: The mass and volume ratio of the anti-allergic extract to water in step 2 is 10~30g:1000~2500mL; the mass and volume ratio of the anti-allergic extract to acetic anhydride is 10~30g:300~900mL.

4. The composition for anti-allergic repair according to claim 1, characterized in that: The mass and volume ratio of silymarin to acetone is 23-26 g:1000-3000 mL; the mass ratio of silymarin, N,N-diisopropylethylamine, and 4-dimethylaminopyridine is 23-26:23-28:0.3-1; and the mass and volume ratio of silymarin to the carbon tetrachloride solution of phosphite is 23-26 g:100-300 mL.

5. The composition for anti-allergic repair according to claim 1, characterized in that: The mass ratio of squalane, glycine, niacinamide, Centella asiatica extract, fibronectin and oat beta-glucan is 10-25:5-15:5-15:10-25:5-15:5-20.

6. The composition for anti-allergic repair according to claim 1, characterized in that: 1g silk fibroin, 1g carrageenan, 40mL water, 10g anti-allergic ingredient, 8g phosphated silymarin, 10g repair ingredient, 0.5g γ-polyglutamic acid, 0.5g polyethylene glycol-20000; The preparation method of the anti-allergic component is as follows: Step 1, 100g of Sophora flavescens powder, 1300g of Radix Ophiopogonis powder, 300g of Radix Scutellariae powder, 200g of Portulaca oleracea powder, 300g of Lithospermum officinale powder, 300g of Radix Lithospermi powder, and 200g of Houttuynia cordata powder are mixed, and then 8000g of water is added, and the mixture is stirred at 90°C and 400 rpm for 60 minutes, cooled to 45°C, and then 700g of cactus powder is added, and the mixture is stirred at 45°C and 400 rpm for 60 minutes, then cooled to 25°C, filtered with a 100-mesh filter, and the filtrate is collected, and then centrifuged at 6000 rpm for 45 minutes to collect the supernatant, and then the supernatant is filtered with a 0.8-micron filter membrane, and the filtrate is collected, and heated and concentrated at 45°C to reduce the volume by 80%, and then freeze-dried to obtain an anti-allergic extract; Step 2: Mix 20 g of the antiallergic extract prepared in step 1 with 1500 mL of water, stir at 400 rpm for 30 minutes, adjust the pH to 9 with 8 mol / L sodium hydroxide aqueous solution, then add 600 mL of acetic anhydride dropwise at a rate of 1 mL / min while stirring at 400 rpm, adjust the pH to 8.3 with 8 mol / L sodium hydroxide aqueous solution every 10 minutes, then continue stirring at 400 rpm for 3 hours at 60°C, then adjust the pH to 7 with 8 mol / L hydrochloric acid, dialyze in water for 3 days, the dialysis molecular weight cut-off is 12 kD, and then freeze-dry to obtain the antiallergic component; The preparation method of the phosphated silymarin is as follows: 24.1 g of silymarin and 1500 mL of acetone were mixed and ultrasonicated for 10 minutes at an ultrasonic power of 250 W. 25.9 g of N,N-diisopropylethylamine and 0.6 g of 4-dimethylaminopyridine were then added. In a 0°C water bath, 200 mL of a 0.25 mmol / mL carbon tetrachloride solution of phosphite was added dropwise at 3 mL / min. The mixture was then stirred at 400 rpm at 20°C for 21 hours, and then evaporated at 55°C for 2.5 hours. The mixture was dissolved in ethyl acetate at 35°C and washed and extracted three times with water and a saturated saline solution. The mixture was then dried over anhydrous sodium sulfate and then evaporated to dryness at 55°C to obtain phosphated silymarin. The repair ingredient is a mixture of 15g squalane, 10g glycine, 10g niacinamide, 20g Centella asiatica extract, 10g fibronectin, and 15g oat beta-glucan.

7. The method for preparing the anti-allergic repair composition according to any one of claims 1 to 6, wherein: The following steps are involved: Add silk fibroin and carrageenan to water, stir at 85-95°C for 10-30 minutes, then add anti-allergic ingredients and phosphated silymarin, continue stirring for 10-30 minutes, then add repair ingredients, γ-polyglutamic acid, and polyethylene glycol-20000, stir for 5-15 minutes to obtain an anti-allergic repair composition.

8. A use of the composition according to any one of claims 1 to 6, characterized in that: The anti-allergic repair composition according to claims 1 to 6 is added to facial masks, facial creams and dressings for use.

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