A dendritic polypeptide nanogel for electrostatic adsorption of hydrogen sulfide on montmorillonite and a preparation method thereof

By loading DATS onto dendritic peptide nanogels and encapsulating montmorillonite, a drug delivery system for controlled H2S release was constructed, solving the problems of significant drug side effects and difficulty in delivering H2S donors in the treatment of colitis, and achieving long-acting sustained release and significant anti-inflammatory and antioxidant effects.

CN116570729BActive Publication Date: 2026-09-15STOMATOLOGICAL HOSPITAL AFFILIATED TO WENZHOU MEDICAL UNIV
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Patent Information

Application Number
CN202310556751.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-05-17
Publication Date
2026-09-15
Estimated Expiration
2043-05-17

AI Technical Summary

Technical Problem

Existing colitis treatments suffer from significant side effects, difficulty in long-term use, poor targeting efficacy, and challenges in achieving controlled release and long-term delivery of H2S donor molecules.

Method used

A multifunctional drug delivery system for controlled H2S release was constructed by using dendritic polypeptide nanogels with hydrogen sulfide electrostatic adsorption on montmorillonite, loading diallyl trisulfide (DATS) molecules into the network structure of the dendritic polypeptide nanogels, and then encapsulating montmorillonite (MMT) on their surface.

Benefits of technology

It achieves long-term sustained release of DATS@PDNs@MMT, significantly inhibits the expression of inflammatory factors, promotes macrophage polarization to anti-inflammatory mode, reduces ROS concentration, promotes colonic epithelial cell proliferation and scratch repair, and has good anti-inflammatory and antioxidant stress resistance properties with high biocompatibility.

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Abstract

The application belongs to the technical field of biological polymers, and particularly relates to a kind of montmorillonite on electrostatic adsorption load hydrogen sulfide dendritic polypeptide nanogel and its preparation method.The present application is polyhedral oligomeric silsesquioxane POSS as the core three generation lysine dendrimer as branched unit POSS-Lys-G3, by crosslinking agent 3,3'-dithiodipropionic acid di(N-hydroxy succinimide) ester DSP Chemical crosslinking to obtain dendritic polypeptide nanogel carrier;In its network structure, load diallyl trisulfide DATS molecule, on its surface, wrap montmorillonite.The beneficial effects of the present application are: can be specific targeting to the damaged mucosa of large intestine and can also release H2S in response to GSH level in physiological state, reduce multiple pro-inflammatory pathways to achieve effective anti-inflammatory effect, and can activate hemin oxygenase expression to resist oxidative stress, have significant in vivo and in vitro anti-inflammatory, and have good biological safety performance.
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