Bubble removing device for liquid circuit and removing method

Abstract

The application relates to a liquid path bubble removing device which comprises a first cleaning liquid container for containing cleaning liquid, a second cleaning liquid container, a cleaning container for placing medical instruments to be cleaned, a buffer container, a first cleaning diaphragm pump and a second cleaning diaphragm pump. The second cleaning liquid container is connected with the first cleaning liquid container through the liquid inlet diaphragm pump. The buffer container is connected with the second cleaning liquid container. The first cleaning diaphragm pump and the second cleaning diaphragm pump are connected with the buffer container. The liquid inlet diaphragm pump, the first cleaning diaphragm pump and the second cleaning diaphragm pump are electrically connected with a controller. The liquid flow and negative pressure can make the cleaning liquid enter the second cleaning liquid container, and most of the bubbles generated by the liquid inlet diaphragm pump can be removed.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical apparatus and instruments, in particular to a liquid path bubble removing device and removing method. BACKGROUND

[0002] Medical apparatus and instruments are mainly clinical devices for detecting tumor markers and various hormones in human body or detecting various cells in human body. Medical apparatus and instruments need to extract a certain amount of blood sample, then mix, react, clean and add substrate liquid with related reagents according to a specified proportion, and then detect in various ways. In order to ensure the accuracy and stability of instrument detection, the sample amount of needle (reagent needle and sample needle) and the injection amount of cleaning liquid need to be accurate.

[0003] The basic reagent required by medical apparatus and instruments is diluent, which is generally an aqueous reagent prepared from water and related solvents. This reagent needs to be diluted with water before use, so a part of gas will naturally dissolve in the water. Therefore, such unnecessary bubbles will exist in the whole liquid path system control process, which will directly affect the sample precision of blood sample or related reagents. Therefore, the bubbles in the liquid path need to be removed.

[0004] There are two ways to remove bubbles in the current liquid path system:

[0005] Method one: select a high-precision quantitative pump. When the instrument needs a quantitative process, use diluent or high-pressure cleaning to reduce the residual bubbles in the pipe that needs to be quantified, so as to reduce the precision error caused by bubbles to the minimum, and use high-precision quantitative pump for precision compensation, so as to force the precision to meet the requirements of the instrument. This method has large cleaning amount, wastes diluent and increases cost. The increase of cleaning amount leads to accelerated wear of part of the liquid path components and short service life.

[0006] Method two: increase a bubble removing device in the liquid path system, which is a special bubble removing device for removing bubbles in the diluent. This device mostly adopts a form similar to a microporous membrane, which divides the diluent into two layers by using a hydrophobic microporous membrane. One layer flows through the microporous membrane, and the other layer applies negative pressure to extract the diluent. In this way, the bubbles will be extracted when the diluent flows through the microporous membrane, achieving the effect of removing bubbles. This device needs to increase a pressure detection mechanism, which has relatively high cost. SUMMARY

[0007] In order to solve the above problems of the prior art, the present application provides a liquid path bubble removing device and removing method, which removes bubbles by controlling the flow mode of gas and liquid in the liquid path and the negative pressure principle.

[0008] To achieve the above purpose, the present application adopts the following technical solutions:

[0009] As an aspect of the present application, a liquid path bubble removing device is provided, which comprises:

[0010] a first cleaning liquid container for containing cleaning liquid;

[0011] a liquid inlet diaphragm pump,

[0012] a second cleaning liquid container, which is in communication with the first cleaning liquid container through the liquid inlet diaphragm pump;

[0013] a cleaning container for placing medical devices to be cleaned;

[0014] a buffer container, a first liquid outlet of which is in communication with a second liquid outlet of the buffer container, an input end of a first cleaning diaphragm pump is in communication with the first liquid outlet of the buffer container, and an output end of the first cleaning diaphragm pump is located in the cleaning container to clean the outer wall of the medical devices to be cleaned;

[0015] a second cleaning diaphragm pump, an input end of which is in communication with a second liquid outlet of the buffer container, and an output end of the second cleaning diaphragm pump is located in the cleaning container to clean the inner wall of the medical devices to be cleaned;

[0016] a waste liquid container, a waste liquid outlet of the cleaning container being in communication with a liquid inlet of the waste liquid container;

[0017] a controller, the liquid inlet diaphragm pump, the first cleaning diaphragm pump and the second cleaning diaphragm pump being electrically connected to the controller.

[0018] Optionally, a vacuum pump is further included, which is electrically connected to the controller, an input end of the vacuum pump being in communication with the waste liquid outlet of the cleaning container, and an output end of the vacuum pump being in communication with the liquid inlet of the waste liquid container.

[0019] Optionally, a first two-way electromagnetic valve is further included, which is electrically connected to the controller, an input end of the first two-way electromagnetic valve being in communication with the output end of the second cleaning diaphragm pump, and an output end of the first two-way electromagnetic valve being located in the cleaning container.

[0020] Optionally, a second two-way electromagnetic valve is further included, which is electrically connected to the controller, an input end of the second two-way electromagnetic valve being in communication with the waste liquid outlet of the cleaning container, and an output end of the second two-way electromagnetic valve being in communication with the liquid inlet of the waste liquid container.

[0021] Optionally, a third two-way electromagnetic valve is further included, which is electrically connected to the controller, an input end of the third two-way electromagnetic valve being in communication with the output end of the first cleaning diaphragm pump, and an output end of the third two-way electromagnetic valve being located in the cleaning container.

[0022] As another aspect of the present application, a removal method of the liquid path bubble removing device is provided, comprising the following steps:

[0023] FP01, the diluent is loaded into the first cleaning liquid container, the liquid inlet diaphragm pump is started to open, and the liquid inlet is started;

[0024] FP02, the diluent enters the second cleaning liquid container, at this time, a large amount of bubbles will be generated under the action of the liquid inlet diaphragm pump, but these bubbles will go up and break on the liquid surface;

[0025] FP03, when the second cleaning liquid container is full, the liquid inlet diaphragm pump stops the liquid inlet, at this time, the diluent is in a static state, which is beneficial to the bubble removal;

[0026] FP04, after the device is installed, there is air in the whole pipeline and the buffer container, when the first cleaning diaphragm pump is opened, the inside of the buffer container is pumped to vacuum, at this time, the vacuum pump is in an open state;

[0027] FP05, the vacuum buffer container is in a negative pressure state, at this time, the diluent will enter the buffer container along the pipeline, the diluent extracted by negative pressure is relatively stable and will not cause a large amount of bubbles due to impact, and the bubbles dissolved in the diluent will be further eliminated due to the negative pressure effect;

[0028] FP06, under the action of the first cleaning diaphragm pump, the diluent enters the cleaning container to clean the outer wall of the medical device to be cleaned, and the vacuum pump extracts the waste liquid;

[0029] FP07, after the diluent enters the cleaning container, the second cleaning diaphragm pump is opened, the diluent flows from the buffer container to the medical device to be cleaned for cleaning.

[0030] The liquid path bubble removing device and the removal method have the following beneficial effects: through the flow of the liquid and the negative pressure effect, the cleaning liquid enters the second cleaning liquid container, and most of the bubbles generated due to the extraction of the liquid inlet diaphragm pump can be removed; the cleaning liquid entering the buffer container from the second cleaning liquid container is extracted by vacuum, the liquid inlet is stable and will not generate bubbles, and the bubbles dissolved in the diluent will be precipitated under the negative pressure condition, further avoiding the influence of the bubbles during cleaning. BRIEF DESCRIPTION OF DRAWINGS

[0031] The drawings accompanying the specification of this application form a part thereof, serve to provide further understanding of the present application, and together with the description of the exemplary embodiments of the present application and the explanation thereof, explain the present application, and do not constitute an improper limitation of the present application.

[0032] Figure 1 It is a structural schematic diagram of the liquid path bubble removing device of the present application. Detailed Implementation

[0033] To better explain and facilitate understanding of the present invention, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0034] An embodiment of the present invention provides a liquid circuit degassing device, such as... Figure 1 As shown, it includes:

[0035] First cleaning fluid container 1, used to hold cleaning fluid;

[0036] Inlet diaphragm pump 2,

[0037] The second cleaning fluid container 5 is connected to the first cleaning fluid container 1 through the inlet diaphragm pump 2; specifically, the outlet of the first cleaning fluid container 1 is connected to the input end of the inlet diaphragm pump 2, and the output end of the inlet diaphragm pump 2 is connected to the inlet of the second cleaning fluid container 5.

[0038] Cleaning container 10 is used to hold medical devices to be cleaned, such as reagent needles;

[0039] The buffer container 11 has its inlet connected to the outlet of the second cleaning fluid container 5.

[0040] The first cleaning diaphragm pump 3 has its input end connected to the first outlet of the buffer container 11 and its output end located inside the cleaning container 10, and cleans the outer wall of the medical device to be cleaned.

[0041] The second cleaning diaphragm pump 4 has its input end connected to the second outlet of the buffer container 11 and its output end located inside the cleaning container 10 to clean the inner wall of the medical device to be cleaned.

[0042] Waste liquid container 12, wherein the waste liquid outlet of the cleaning container 10 is connected to the liquid inlet of the waste liquid container 12;

[0043] The controller is electrically connected to the inlet diaphragm pump 2, the first cleaning diaphragm pump 3, and the second cleaning diaphragm pump 4 respectively. The controller controls the inlet diaphragm pump 2 to transfer the cleaning liquid from the first cleaning liquid container 1 to the second cleaning liquid container 5. When the second cleaning liquid container 5 is full of cleaning liquid, the controller controls the inlet diaphragm pump 2 to shut down.

[0044] As further explained, this embodiment also includes a vacuum pump 6, which is electrically connected to the controller. The input end of the vacuum pump 6 is connected to the waste liquid outlet of the cleaning container 10, and the output end of the vacuum pump 6 is connected to the liquid inlet of the waste liquid container 12.

[0045] As further illustration, in this embodiment, a first two-way electromagnetic valve 7 is also included, which is electrically connected to the controller, the input end of the first two-way electromagnetic valve 7 is connected to the output end of the second cleaning diaphragm pump 4, and the output end of the first two-way electromagnetic valve 7 is located in the cleaning container 10 to clean the inner wall of the medical device to be cleaned.

[0046] As further illustration, in this embodiment, a second two-way electromagnetic valve 8 is also included, which is electrically connected to the controller, the input end of the second two-way electromagnetic valve 8 is connected to the waste liquid outlet of the cleaning container 10, and the output end of the second two-way electromagnetic valve 8 is connected to the liquid inlet of the waste liquid container 12.

[0047] As further illustration, in this embodiment, a third two-way electromagnetic valve 9 is also included, which is electrically connected to the controller, the input end of the third two-way electromagnetic valve 9 is connected to the output end of the first cleaning diaphragm pump 3, and the output end of the third two-way electromagnetic valve 9 is located in the cleaning container 10 to clean the outer wall of the medical device to be cleaned.

[0048] It should be noted that the medium flow passages between the components are connected by pipelines, which are pipe fittings, and this connection mode and structure are prior art and will not be described in detail.

[0049] In this embodiment, the controller controls the first cleaning diaphragm pump 3 to open, at this time, the third two-way electromagnetic valve 9 is switched from the normally closed state to the normally open state, at the same time, the second two-way electromagnetic valve 8 is switched from the normally closed state to the normally open state, and the vacuum pump 6 is opened, when the diluent enters the cleaning container 10, the second cleaning diaphragm pump 4 is opened, the first two-way electromagnetic valve 7 is switched from the normally closed state to the normally open state, until the diluent fills the pipeline, at this time, the controller controls the liquid inlet diaphragm pump 2, the first cleaning diaphragm pump 3, the second cleaning diaphragm pump 4 and the vacuum pump 6 to stop working, and the first two-way electromagnetic valve 7, the second two-way electromagnetic valve 8 and the third two-way electromagnetic valve 9 are all switched to the normally closed state.

[0050] In this embodiment, most of the air bubbles generated by the extraction of the liquid inlet diaphragm pump 2 are removed by the second cleaning liquid container 5, and most of the air bubbles in the diluent are removed by the buffer container 11. Therefore, the device utilizes the characteristic that air bubbles will go up under the action of negative pressure to remove the air bubbles in the pipeline.

[0051] The present application also provides a removal method for the liquid path bubble removal device as described above, comprising the following steps:

[0052] FP01, the diluent is loaded into the first cleaning liquid container 1, the liquid inlet diaphragm pump 2 is started to open, and the liquid inlet begins;

[0053] FP02, the diluent enters the second cleaning liquid container 5, at this time, a large amount of bubbles will be generated due to the action of the liquid inlet diaphragm pump 2, but these bubbles will go up and break on the liquid surface;

[0054] FP03, when the second cleaning liquid container 5 is full, the liquid inlet diaphragm pump 2 stops liquid inlet, at this time, the diluent is in a static state, which is beneficial to bubble discharge;

[0055] FP04, after the device is installed, there is air in the whole pipeline and the buffer container 11, when the first cleaning diaphragm pump 3 is opened, the buffer container 11 is pumped to vacuum; at this time, the vacuum pump 6 is in an open state;

[0056] FP05, the vacuum buffer container 11 is in a negative pressure state, at this time, the diluent will enter the buffer container 11 along the pipeline, the diluent extracted by negative pressure is relatively stable and will not cause a large amount of bubbles due to impact, and at the same time, the bubbles dissolved in the diluent will be further eliminated due to the negative pressure effect;

[0057] FP06, under the action of the first cleaning diaphragm pump 3, the diluent enters the cleaning container 10 to clean the outer wall of the medical device to be cleaned, such as a reagent needle, and the vacuum pump 6 extracts the waste liquid;

[0058] FP07, after the diluent enters the cleaning container 10, the second cleaning diaphragm pump 4 is opened, and the diluent flows from the buffer container 11 to the medical device to be cleaned, such as a reagent needle, to clean it.

[0059] It should be noted that the pumps and valves involved in the whole liquid path need to be opened during the perfusion process, and the pumps and valves need to be closed or reset after the whole perfusion is completed.

[0060] The bubble removing method of the liquid path of the embodiment is performed before the medical device is used, and the principle of bubble removal is that bubbles will be separated out when the liquid is static; under the action of negative pressure, the bubble separation speed is accelerated; this way is simple to operate, low in cost and easy to control.

[0061] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, the singular form is intended to include the plural form, unless the context clearly indicates otherwise, and it should also be understood that, when the terms "comprise" and / or "include" are used in the specification, there is a presence of the features, steps, operations, devices, components and / or combinations thereof.

[0062] The foregoing is considered as illustrative only of the principles of the application. Other variations and modifications are possible in light of the above teachings. Therefore, the scope of the application is not intended to be limited to the particular embodiments described herein but is to be accorded the broadest scope consistent with the scope of the claims, with the full scope of such claims being defined in the claims. The embodiments described herein and / or shown in the accompanying drawings are susceptible to various modifications and alternative forms, specific examples thereof having been shown and described as illustrative only. It should be understood by those skilled in the art that the application is not intended to be limited to the particular embodiments described herein above but encompasses all modifications made by one of ordinary skill in the art to adapt and / or modify the present application to and / or for other applications of the application. Accordingly, the application is not limited to that precisely as shown and described. Various features and aspects of the above-described application can be used individually or jointly. Further, the application can be utilized in any number of environments and applications beyond the transfer of data specified herein, including performance of other transactions, accounting, and recording, cash management, and the like. Further, the separation of various features of the application is for illustrative purposes only and should not be used to argue that such features must be separable. Hence, one skilled in the art will readily appreciate that the application is well adapted to carry out the objects and obtain the ends and advantages mentioned, as well as those inherent therein, and that the application is not limited to the details of the foregoing, unless such details are given to support the claims.

[0063] In the description of the present application, it is to be understood that the specific location or position relationships indicated by the orientation words such as "front, back, upper, lower, left, right", "horizontal, vertical, perpendicular, horizontal" and "top, bottom" and the like are generally based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate and imply that the devices or elements referred to must have a particular orientation or be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the scope of protection of the present application; the orientation words "inner, outer" refer to the inner and outer relative to the contour of each component.

[0064] For the convenience of description, spatial relative terms such as "over", "above", "upper surface", "upper" and the like can be used herein to describe the spatial position relationship of one device or feature with other devices or features as shown in the drawings. It should be understood that the spatial relative terms are intended to include different orientations in use or operation in addition to the orientation of the devices described in the drawings. For example, if the devices in the drawings are inverted, the device described as "above" or "over" other devices or structures will be positioned "below" or "under" the other devices or structures. Thus, the example term "above" can include both "above" and "below" orientations. The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein are interpreted accordingly.

[0065] In addition, it should be noted that the use of the words "first", "second" and the like to describe various components is merely intended to distinguish the various components from each other, and such words do not have special meanings unless otherwise stated, and therefore cannot be understood as a limitation on the scope of protection of the present application.

[0066] In the description of the present application, it should be noted that unless specifically stated and limited otherwise, the terms "mounting", "provided with", "connected" and the like, should be understood broadly, for example, "connected" can be fixedly connected, or detachably connected, or integrally connected; can be mechanically connected, or electrically connected; can be directly connected, or indirectly connected through an intermediate medium, or can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0067] The above only describes the preferred embodiments of the present application, and any changes and modifications made within the scope of the patent application of the present application shall be covered by the present application.

Claims

1. A removal method of a liquid path bubble removing device, characterized by, It comprises the following steps: FP01, the diluent is loaded into the first cleaning liquid container, the inlet diaphragm pump is started to open, and the liquid inlet is started; FP02, the diluent enters the second cleaning liquid container, at this time, a large amount of bubbles will be generated under the action of the inlet diaphragm pump, but these bubbles will go up and break on the liquid surface; FP03, when the second cleaning liquid container is full, the inlet diaphragm pump stops the liquid inlet, at this time, the diluent is in a static state, which is beneficial to the bubble discharge; FP04, after the device is installed, the first cleaning diaphragm pump is opened, and the inside of the buffer container is pumped to vacuum; at this time, the vacuum pump is in an open state; FP05, the vacuum buffer container is in a negative pressure state, at this time, the diluent enters the buffer container, the diluent extracted by negative pressure is relatively stable, and a large amount of bubbles will not be generated due to impact, and the bubbles dissolved in the diluent will be further eliminated due to the negative pressure effect; FP06, under the action of the first cleaning diaphragm pump, the diluent enters the cleaning container to clean the outer wall of the medical device to be cleaned, and the vacuum pump extracts the waste liquid; FP07, after the diluent enters the cleaning container, the second cleaning diaphragm pump is opened, and the diluent flows from the buffer container to the medical device to be cleaned to clean the inner wall thereof; The liquid path bubble removing device comprises: A first cleaning liquid container for loading cleaning liquid; An inlet diaphragm pump, A second cleaning liquid container, which is connected with the first cleaning liquid container through the inlet diaphragm pump; A cleaning container for placing the medical device to be cleaned; A buffer container, the liquid inlet of the buffer container is connected with the liquid outlet of the second cleaning liquid container; A first cleaning diaphragm pump, the input end of the first cleaning diaphragm pump is connected with the first liquid outlet of the buffer container, and the output end of the first cleaning diaphragm pump is located in the cleaning container to clean the outer wall of the medical device to be cleaned; A second cleaning diaphragm pump, the input end of the second cleaning diaphragm pump is connected with the second liquid outlet of the buffer container, and the output end of the second cleaning diaphragm pump is located in the cleaning container to clean the inner wall of the medical device to be cleaned; A controller, the inlet diaphragm pump, the first cleaning diaphragm pump and the second cleaning diaphragm pump are respectively electrically connected with the controller; Further comprising a vacuum pump, the vacuum pump is electrically connected with the controller, and the input end of the vacuum pump is connected with the waste liquid outlet of the cleaning container.

2. The bubble removing method of the liquid path deaerator according to claim 1, characterized by, Further comprising a waste liquid container, the liquid inlet of the waste liquid container is connected with the waste liquid outlet of the cleaning container.

3. The bubble removing method of the liquid path bubble removing device according to claim 1 or 2, characterized by, Further comprising a first two-way electromagnetic valve, the first two-way electromagnetic valve is electrically connected with the controller, the input end of the first two-way electromagnetic valve is connected with the output end of the second cleaning diaphragm pump, and the output end of the first two-way electromagnetic valve is located in the cleaning container.

4. The bubble removing method of the liquid path deaerator according to claim 1 or 2, characterized by, Further comprising a second two-way electromagnetic valve, the second two-way electromagnetic valve is electrically connected with the controller, the input end of the second two-way electromagnetic valve is connected with the waste liquid outlet of the cleaning container, and the output end of the second two-way electromagnetic valve is connected with the liquid inlet of the waste liquid container.

5. The bubble removing method of the liquid path bubble removing device according to claim 1 or 2, characterized by, The third two-way electromagnetic valve is electrically connected with the controller, the input end of the third two-way electromagnetic valve is communicated with the output end of the first cleaning diaphragm pump, and the output end of the third two-way electromagnetic valve is located in the cleaning container.

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