An peracetic acid disinfectant solution for endoscopic disinfection and its application

Abstract

The present invention provides a peracetic acid disinfectant solution for endoscopic disinfection. Different from conventional disinfectants, the disinfectant in the present invention, considering factors such as the endoscopic washing and disinfection environment, the characteristics of peracetic acid, and user-friendliness, adopts the form of combining peracetic acid with a corrosion inhibitor. On the premise of ensuring qualified high-level disinfection or sterilization of the endoscope, it effectively alleviates the corrosiveness of peracetic acid. During use, the two are directly mixed without activation waiting or the need to additionally add purified water, greatly improving the convenience and work efficiency in hospital use. The present invention also provides an application of the peracetic acid disinfectant solution in endoscopic disinfection.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical disinfection, and particularly relates to a peracetic acid disinfectant solution for endoscopic disinfection and its application. Background Art

[0002] According to the national specifications for the cleaning and disinfection of flexible endoscopes, it is required that all flexible endoscopes should be thoroughly cleaned and highly level disinfected or sterilized after each use. The specifications also point out the principles to be followed for the classified treatment of flexible endoscopes and reusable accessories and medical supplies. Flexible endoscopes and accessories that enter sterile tissues, organs of the human body, or come into contact with damaged skin or damaged mucous membranes should be sterilized; flexible endoscopes and affiliated articles and instruments that come into contact with intact mucous membranes, but do not enter sterile tissues, organs of the human body, and do not come into contact with damaged skin or damaged mucous membranes should be highly level disinfected.

[0003] Currently, the main disinfectants used for the high-level disinfection or sterilization of endoscopes are glutaraldehyde, ortho-phthalaldehyde, or traditional peracetic acid, etc. Some of these disinfectants are difficult to achieve the sterilization level, such as ortho-phthalaldehyde; some have too long disinfection and sterilization time, such as glutaraldehyde; some have greater corrosion to endoscopes or are inconvenient to use, such as traditional peracetic acid. Currently, most existing peracetic acid disinfectants use the method of directly using diluted peracetic acid for the high-level disinfection or sterilization of flexible endoscopes. This method has problems such as high corrosiveness and inconvenience for users. Summary of the Invention

[0004] The purpose of the present invention is to provide a peracetic acid disinfectant solution for endoscopic disinfection and its application. The peracetic acid disinfectant solution in the present invention can effectively reduce the corrosiveness of peracetic acid, is convenient to use, does not require activation waiting or additional purified water, and improves the convenience and work efficiency of hospital use.

[0005] The present invention provides a peracetic acid disinfectant solution for endoscopic disinfection, which includes component A and component B;

[0006] Component A includes 0.1 - 35 wt% of hydrogen peroxide, 0.3 - 20 wt% of peracetic acid, 0.001 - 0.1 wt% of stabilizer, and the balance of water;

[0007] Component B includes 0.005 - 0.1 wt% of corrosion inhibitor, 0.001 - 0.1 wt% of surfactant, 4 - 10 wt% of pH regulator, and the balance of water;

[0008] The corrosion inhibitor is one or several of 2 - [1 - (p - tolylsulfonyl)-1H-[1,2,3]triazol - 4 - yl]-propanol, 5 - methyl - 1H - benzotriazole, 1 - (4 - iodobenzyl)-4 - phenoxymethyl - 1H - 1,2,3 - triazole, 1 - (4 - pyridylmethyl)pyridine - 1H - 1,2,3 - triazole - 4 - methanol, and 1 - p - tolyl - 1H - 1,2,3 - triazole - 4 - methanol.

[0009] Preferably, the stabilizer is hydroxyethylidene diphosphonic acid and / or sodium tripolyphosphate.

[0010] Preferably, the surfactant is sodium dodecylbenzenesulfonate.

[0011] Preferably, the pH regulator is sodium dihydrogen phosphate and / or potassium dihydrogen phosphate.

[0012] Preferably, in the mixed solution of component A and component B, the mass concentration of peracetic acid is 0.2 - 0.4%.

[0013] The present invention provides the application of the peracetic acid disinfectant for endoscopic disinfection as described above in endoscopic disinfection.

[0014] Preferably, when in use, component A and component B are mixed in proportion and used directly.

[0015] The present invention provides a peracetic acid disinfectant for endoscopic disinfection, comprising component A and component B; component A comprises 0.1 - 35 wt% of hydrogen peroxide, 0.3 - 20 wt% of peracetic acid, 0.001 - 0.1 wt% of stabilizer, and the balance of water; component B comprises 0.005 - 0.1 wt% of corrosion inhibitor, 0.001 - 0.1 wt% of surfactant, 4 - 10 wt% of pH regulator, and the balance of water; the corrosion inhibitor is one or several of 2 - [1 - (p - tolylsulfonyl)-1H-[1,2,3]triazol - 4 - yl]-propanol, 5 - methyl - 1H - benzotriazole, 1 - (4 - iodobenzyl)-4 - phenoxymethyl - 1H - 1,2,3 - triazole, 1 - (4 - pyridylmethyl)pyridine - 1H - 1,2,3 - triazole - 4 - methanol, and 1 - p - tolyl - 1H - 1,2,3 - triazole - 4 - methanol. Different from conventional disinfectants, the disinfectant in the present invention, considering factors such as the endoscopic disinfection and washing environment, the characteristics of peracetic acid, and user - friendly use, adopts the form of combining peracetic acid with a corrosion inhibitor. On the premise of ensuring qualified high - level disinfection or sterilization of the endoscope, it effectively alleviates the corrosiveness of peracetic acid. During the use process, the two are directly mixed without activation waiting and without the need to add additional purified water, greatly improving the convenience and work efficiency in hospital use. Detailed implementation manners

[0016] The present invention provides a peracetic acid disinfectant solution for endoscopic disinfection, which comprises component A and component B;

[0017] Component A comprises 0.1-35 wt% of hydrogen peroxide, 0.3-20 wt% of peracetic acid, 0.001-0.1 wt% of a stabilizer and the balance of water;

[0018] Component B comprises 0.005-0.1 wt% of a corrosion inhibitor, 0.001-0.1 wt% of a surfactant, 4-10 wt% of a pH regulator and the balance of water;

[0019] The corrosion inhibitor is one or more of 2-[(1-toluene-4-sulfonyl)-1H-[1,2,3]triazol-4-yl]-propanol, 5-methyl-1H-benzotriazole, 1-(4-iodobenzyl)-4-phenoxymethyl-1H-1,2,3-triazole, 1-(4-pyridylmethylpyridine)-1H-1,2,3-triazole-4-methanol and 1-p-tolyl-1H-1,2,3-triazole-4-methanol.

[0020] In the present invention, in component A, the mass fraction of hydrogen peroxide is preferably 0.1-35%, more preferably 1-30%, such as 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, and is preferably a range value with any of the above values as the upper or lower limit; the mass fraction of peracetic acid is preferably 0.3-20%, more preferably 1-15%, such as 0.3%, 0.5%, 1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, and is preferably a range value with any of the above values as the upper or lower limit.

[0021] The stabilizer is preferably hydroxyethylidene diphosphonic acid and / or sodium tripolyphosphate, and the mass fraction of the stabilizer is preferably 0.001-0.1%, more preferably 0.01-0.08%, such as 0.001%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, and is preferably a range value with any of the above values as the upper or lower limit.

[0022] In the present invention, among the component B, the corrosion inhibitor is preferably one or more of 2-[(1-tolyl-4-sulfonyl)-1H-[1,2,3]triazol-4-yl]-propanol, 5-methyl-1H-benzotriazole, 1-(4-iodobenzyl)-4-phenoxymethyl-1H-1,2,3-triazole, 1-(4-picolylpyridine)-1H-1,2,3-triazole-4-methanol, and 1-p-tolyl-1H-1,2,3-triazole-4-methanol; the mass fraction of the corrosion inhibitor is preferably 0.005 to 0.1%, more preferably 0.01 to 0.08%, such as 0.005%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, and is preferably a range value with any of the above-mentioned values as the upper or lower limit.

[0023] The surfactant is preferably sodium dodecylbenzenesulfonate, and the mass fraction of the surfactant is preferably 0.001 to 0.1%, more preferably 0.01 to 0.08%, such as 0.001%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, and is preferably a range value with any of the above-mentioned values as the upper or lower limit.

[0024] The pH regulator is preferably sodium dihydrogen phosphate and / or potassium dihydrogen phosphate, and the mass fraction of the pH regulator is preferably 4 to 10%, more preferably 5 to 8%, such as 4%, 5%, 6%, 7%, 8%, 9%, 10%, and is preferably a range value with any of the above-mentioned values as the upper or lower limit.

[0025] In the present invention, in the mixed solution of component A and component B, the mass concentration of peracetic acid is preferably 0.2 to 0.4%, more preferably 0.3 to 0.35%.

[0026] The present invention has no special requirements for the preparation methods of component A and component B, and the corresponding components can be mixed with water to obtain them.

[0027] The present invention also provides an application of the peracetic acid disinfectant for endoscopic disinfection described above in endoscopic disinfection.

[0028] The disinfectant in the present invention is more convenient to use. After directly mixing component A and component B, it can be used without activation waiting and without additional addition of purified water, improving the convenience and working efficiency of hospital use.

[0029] The present invention provides a peracetic acid disinfectant solution for endoscopic disinfection, which comprises component A and component B; component A comprises 0.1-35 wt% of hydrogen peroxide, 0.3-20 wt% of peracetic acid, 0.001-0.1 wt% of a stabilizer and the balance of water; component B comprises 0.005-0.1 wt% of a corrosion inhibitor, 0.001-0.1 wt% of a surfactant, 4-10 wt% of a pH regulator and the balance of water; the corrosion inhibitor is one or more of 2-[1-(toluene-4-sulfonyl)-1H-[1,2,3]triazol-4-yl]-propanol, 5-methyl-1H-benzotriazole, 1-(4-iodobenzyl)-4-phenoxymethyl-1H-1,2,3-triazole, 1-(4-pyridylmethyl)-1H-1,2,3-triazole-4-methanol and 1-p-tolyl-1H-1,2,3-triazole-4-methanol. Different from conventional disinfectants, the disinfectant in the present invention, considering factors such as the endoscopic disinfection and cleaning environment, the characteristics of peracetic acid and user-friendliness, adopts the form of combination of peracetic acid and a corrosion inhibitor, effectively alleviates the corrosiveness of peracetic acid on the premise of ensuring qualified high-level disinfection or sterilization of the endoscope, and during the use process, the two are directly mixed without activation waiting and without additional addition of purified water, greatly improving the convenience of use and work efficiency in hospitals.

[0030] In order to further illustrate the present invention, the following describes in detail a peracetic acid disinfectant solution for endoscopic disinfection and its application provided by the present invention in combination with embodiments, but it should not be construed as a limitation to the protection scope of the present invention.

[0031] Example 1

[0032] Agent A: hydrogen peroxide 12 wt%, peracetic acid 7 wt%, 1-hydroxyethylidene-1,1-diphosphonic acid 0.05 wt%, and the balance is water;

[0033] Agent B: 2-[1-(toluene-4-sulfonyl)-1H-[1,2,3]triazol-4-yl]-propanol 0.05 wt%, sodium dodecylbenzenesulfonate 0.01 wt%, sodium dihydrogen phosphate 4 wt%, and the balance is water.

[0034] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0035] Example 2

[0036] Agent A: hydrogen peroxide 12 wt%, peracetic acid 7 wt%, 1-hydroxyethylidene-1,1-diphosphonic acid 0.05 wt%, and the balance is water;

[0037] Agent B: 1-p-tolyl-1H-1,2,3-triazole-4-methanol 0.05 wt%, sodium dodecylbenzenesulfonate 0.01 wt%, sodium dihydrogen phosphate 4 wt%, and the balance is water.

[0038] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0039] Example 3

[0040] Agent A: hydrogen peroxide is 12 wt%, peracetic acid is 7 wt%, 1-hydroxyethylidene-1,1-diphosphonic acid is 0.05 wt%, and the balance is water;

[0041] Agent B: 1-(4-iodobenzyl)-4-phenoxymethyl-1H-1,2,3-triazole is 0.05 wt%, sodium dodecylbenzenesulfonate is 0.01 wt%, sodium dihydrogen phosphate is 4 wt%, and the balance is water.

[0042] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0043] Example 4

[0044] Agent A: hydrogen peroxide is 12 wt%, peracetic acid is 7 wt%, 1-hydroxyethylidene-1,1-diphosphonic acid is 0.05 wt%, and the balance is water;

[0045] Agent B: 1-(4-pyridylmethyl)-1H-1,2,3-triazole-4-methanol is 0.1 wt%, sodium dodecylbenzenesulfonate is 0.01 wt%, sodium dihydrogen phosphate is 4 wt%, and the balance is water.

[0046] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0047] Example 5

[0048] Agent A: hydrogen peroxide is 12 wt%, peracetic acid is 7 wt%, 1-hydroxyethylidene-1,1-diphosphonic acid is 0.05 wt%, and the balance is water;

[0049] Agent B: 1-(4-pyridylmethyl)-1H-1,2,3-triazole-4-methanol is 0.05 wt%, 5-methyl-1H-benzotriazole is 0.05 wt%, sodium dodecylbenzenesulfonate is 0.01 wt%, sodium dihydrogen phosphate is 4 wt%, and the balance is water.

[0050] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0051] Example 6

[0052] Agent A: hydrogen peroxide is 12 wt%, peracetic acid is 7 wt%, 1-hydroxyethylidene-1,1-diphosphonic acid is 0.05 wt%, and the balance is water;

[0053] Agent B: 1-p-tolyl-1H-1,2,3-triazole-4-methanol is 0.05 wt%, 5-methyl-1H-benzotriazole is 0.05 wt%, sodium dodecylbenzenesulfonate is 0.01 wt%, sodium dihydrogen phosphate is 4 wt%, and the balance is water.

[0054] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0055] Comparative Example 1

[0056] Agent A contains 12 wt% hydrogen peroxide, 7 wt% peracetic acid, 0.05 wt% hydroxyethane diphosphonic acid, and the balance is water;

[0057] Agent B consists of 0.05 wt% benzotriazole, 0.01 wt% sodium dodecylbenzenesulfonate, 4 wt% sodium dihydrogen phosphate, and the balance is water.

[0058] After mixing Agent A and Agent B, the concentration of peracetic acid is 0.3%

[0059] Use the disinfectants in Examples 1-6 and Comparative Example 1 for the metal corrosion test conditions

[0060] Detection environment: Temperature: 20°C, Humidity: 52% RH;

[0061] Inspection basis: "Disinfection Technical Specification" (2002 Edition) 2.2.4

[0062] Table 1 Corrosion rates (mm / a) of the disinfectants in the examples and comparative examples

[0063] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Stainless steel 0.0048 0.0076 0.0093 0.0084 0.0037 0.0044 0.0157 Carbon steel 0.0789 0.1004 0.0974 0.0896 0.0598 0.0879 1.9872 Aluminum 0.0509 0.0967 0.0567 0.0254 0.0079 0.0096 0.8254 Copper 0.1688 0.1979 0.1989 0.1845 0.0988 0.1378 1.2638

[0064] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A peracetic acid disinfectant solution for endoscopic disinfection, comprising component A and component B; Component A comprises 12 wt% hydrogen peroxide, 7 wt% peracetic acid, 0.05 wt% stabilizer and the balance water; Component B comprises 0.05 wt% corrosion inhibitor, 0.01 wt% surfactant, 4 wt% pH regulator and the balance water; The corrosion inhibitor is one or more of 2 - [1 - (toluene - 4 - sulfonyl)-1H-[1,2,3]triazol - 4 - yl]-propanol, 5 - methyl - 1H - benzotriazole, 1 - (4 - iodobenzyl)-4 - phenoxymethyl - 1H - 1,2,3 - triazole, 1 - (4 - pyridylmethylpyridine)-1H - 1,2,3 - triazole - 4 - methanol and 1 - p - tolyl - 1H - 1,2,3 - triazole - 4 - methanol; The stabilizer is hydroxyethylidene diphosphonic acid and / or sodium tripolyphosphate; the surfactant is sodium dodecylbenzenesulfonate; the pH regulator is sodium dihydrogen phosphate and / or potassium dihydrogen phosphate; In the mixed solution of component A and component B, the mass concentration of peracetic acid is 0.2 - 0.4%.

2. Use of the peracetic acid disinfectant solution for endoscopic disinfection according to claim 1 in endoscopic disinfection.

3. The application according to claim 2, wherein When in use, component A and component B are mixed in proportion and used directly.