A method to increase the adsorption capacity of resin microspheres

Abstract

This invention discloses a method for increasing the adsorption capacity of resin microspheres. The method includes: first soaking the resin microspheres in a mixture of ethanol and N-methylpyrrolidone; then soaking the resin microspheres in an alkaline or acidic solution until the pH value is 8-9; and finally soaking the resin microspheres in a buffer solution with a pH of 8-9 at a temperature below 5°C. Compared with the prior art, the method of this invention for increasing the adsorption capacity of resin has the advantages of simple operation and low cost. After treatment by this method, the adsorption capacity of the resin is significantly increased.

Description

Technical Field

[0001] This invention relates to a method for increasing the adsorption capacity of resin microspheres. Background Technology

[0002] Resins are widely used in wastewater treatment, pharmaceutical separation and purification, as carriers for chemical reaction catalysts, and as packing material for gas chromatography and gel permeation chromatography molecular weight fractionation columns. Compared with activated carbon, resins have the advantages of easy regeneration and repeated use, but their adsorption capacity is not ideal. Summary of the Invention

[0003] To overcome the drawback of insufficient resin adsorption capacity, this invention provides a method for increasing the adsorption capacity of resin microspheres.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] A method for increasing the adsorption capacity of resin microspheres includes:

[0006] First, soak the resin microspheres in a mixture of ethanol and N-methylpyrrolidone;

[0007] The resin microspheres are then soaked in alkaline or acidic solutions until the pH value reaches 8-9.

[0008] Finally, the resin microspheres were soaked in a buffer solution with a pH of 8-9 at a temperature below 5°C.

[0009] Compared with the prior art, the method of the present invention for increasing resin adsorption capacity has the advantages of simple operation and low cost. After treatment by this method, the adsorption capacity of the resin is significantly increased. Detailed Implementation

[0010] The technical solution of the present invention will be further described in detail below with reference to preferred embodiments.

[0011] A method for increasing the adsorption capacity of resin microspheres includes the following steps:

[0012] First, soak the resin microspheres in a mixture of ethanol and N-methylpyrrolidone;

[0013] The resin microspheres are then soaked in alkaline or acidic solutions until the pH value reaches 8-9.

[0014] Finally, the resin microspheres were soaked in a buffer solution with a pH of 8-9 at a temperature below 5°C.

[0015] In some preferred embodiments of the present invention, the volume ratio of ethanol to N-methylpyrrolidone is 1:1.

[0016] Soaking the resin microspheres in alkaline or acidic solution to a pH of 8-9 is crucial for subsequent buffer treatment.

[0017] In some preferred embodiments of the present invention, the alkaline solution is a sodium hydroxide solution or a potassium hydroxide solution.

[0018] In some preferred embodiments of the present invention, the concentration of the sodium hydroxide solution or potassium hydroxide solution is 50 mg / L.

[0019] In some preferred embodiments of the present invention, the resin microspheres are soaked in buffer solution at 3–5°C for 10–24 hours. Low temperature is one of the key factors in the buffer solution treatment of resin microspheres in this invention; above this temperature, the effect of increasing resin adsorption capacity cannot be achieved.

[0020] In some preferred embodiments of the present invention, the buffer solution is a triethanolamine buffer solution or a potassium phosphate buffer solution.

[0021] In some preferred embodiments of the present invention, the pH value of the buffer solution is 8.5.

[0022] In some preferred embodiments of the present invention, the resin microspheres are polystyrene resin microspheres.

[0023] Example 1

[0024] Preparation of resin microspheres:

[0025] The resin microspheres used were commercially available polystyrene resin microspheres. Since the particle size distribution of commercially available resin microspheres is relatively wide, the resin microspheres with a particle size of 0.3-0.6 mm were obtained by centrifugation (centrifugation speed 7000 r / min) for later use.

[0026] Treatment to enhance adsorption capacity using resin microspheres:

[0027] 1. Resin molding is performed using strong acids and alkalis. The resin microspheres produced by the manufacturer have pores distributed on their surface, which contain many microparticles and chemical reagents. The resin microspheres are soaked in anhydrous ethanol / N-methylpyrrolidone at a volume ratio of 1:1 to dissolve the microparticles in the surface pores. The microspheres are then filtered through a 150nm membrane to leave clean resin microspheres for later use.

[0028] 2. Then, soak the resin microspheres in a 50 mg / L sodium hydroxide solution for 8 hours. Measure the pH value of the resin microspheres in the sodium hydroxide solution until the pH value reaches the optimal level of 8.5. The purpose of using sodium hydroxide is to neutralize the acidic deposits on the resin microspheres.

[0029] 3. Soak the treated resin microspheres in triethanolamine buffer or potassium phosphate buffer at pH 8.5 for 16 hours at a low temperature (4 degrees Celsius) to improve the adsorption effect of the resin microspheres.

[0030] The buffer solution was prepared according to existing technology.

[0031] 4. Comparison of the adsorption results of uric acid in plasma by resin microspheres.

[0032] Experimental procedure:

[0033] 1. Experimental Objective

[0034] To enhance the adsorption capacity of resin microspheres

[0035] 2. Experimental Methods

[0036] (1) Stabilize 2L of plasma at 37 degrees Celsius and stabilize the uric acid concentration in the plasma at a certain value.

[0037] (2) Take 200g of resin microspheres (0.3-0.6mm) and fill them into a hemoperfusion device. Under the condition that the plasma flow rate is 100ml / min, test the effect of resin microspheres on the removal of uric acid in plasma.

[0038] The results are as follows:

[0039]

[0040] The experimental results above show that the adsorption capacity of resin microspheres for uric acid is significantly improved after treatment with the present invention.

[0041] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for increasing the adsorption capacity of resin microspheres for uric acid, comprising: First, soak the resin microspheres in a mixture of ethanol and N-methylpyrrolidone; The resin microspheres are then soaked in alkaline solution until the pH value reaches 8-9; Finally, the resin microspheres were soaked in a buffer solution with a pH of 8.5 at 3-5°C for 10-24 hours. The volume ratio of ethanol to N-methylpyrrolidone is 1:1; The alkaline solution is a sodium hydroxide solution or a potassium hydroxide solution; The concentration of the sodium hydroxide solution or potassium hydroxide solution is 50 mg / L; The buffer solution is a triethanolamine buffer or a potassium phosphate buffer; The resin microspheres are polystyrene resin microspheres.

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