Tablet grinding and dissolving device

Abstract

A tablet grinding and dissolving device for preparing a nasal feeding medicine, comprising: a grinding part for grinding and processing tablet or granular medicine particles into a nasal feeding medicine powder; a dissolving part for mixing the nasal feeding medicine powder and a solvent with a set volume into a nasal feeding medicine solution with a target concentration; a taking part for dispensing a target dose of the nasal feeding medicine solution from the dissolving part to a nasal feeding input pipeline and / or a storage container in communication with the nasal feeding input pipeline; the device is further provided with a flushing assembly for transferring the nasal feeding medicine powder from the grinding part to the dissolving part, wherein the flushing assembly performs multiple flushing of the grinding part in a manner distinguished by at least flushing parameters, the flushing parameters at least including a flushing volume. The scheme can provide accurate solvent flushing for the ground nasal feeding medicine powder, thereby quickly transferring the medicine powder by utilizing the similar compatibility of the medicine powder and the solvent, and directly preparing the liquid medicine, thereby significantly improving the efficiency and dose accuracy of the prepared medicine.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medicine processing, and relates to a medicine tablet grinding and dissolving device, in particular to a nasal feeding medicine grinding and dissolving device. BACKGROUND

[0002] In a scenario where medicine needs to be administered to a patient, for example in a hospital scenario, or a patient care scenario, medicine configuration is a common type of work. Due to differences in individual patient conditions, it may be necessary to split a standard medicine dose into a more micro-dose according to a doctor's order or following the instructions for use of the medicine. For example, a tablet or pill is often cut into 1 / 8, 1 / 16, or even 1 / 20. Since existing tablet splitting is difficult to accurately cut the tablet, the medicine is ground into powder and configured into a solution containing the corresponding amount of medicine using a solvent, and then the solution is provided to the patient. On the other hand, there are also scenarios where flexible medicine dispensing is directly required for patients, often requiring medical staff or dispensers to weigh the required amount of medicine, grind it into powder, and then add the appropriate solvent to make the target medicine.

[0003] In addition, for people in a coma, esophageal stenosis, oral cavity disease, premature infants, and critically ill patients, especially infants and the like, especially patients in ICU or CCU, since the patients themselves cannot swallow medicine, some types of medicine are often fed to the patients through nasal feeding to enable the patients to absorb the medicine. Although the hospital purchases medicines with ready-made dosage forms, in the face of the need for nasal feeding, qualified personnel are required to grind the solid type of medicine that can be ground and dispensed into powder and dissolve or mix the powder with an appropriate solvent to form a nasal feeding medicine solution, and then pass the nasal feeding medicine solution into the nasal feeding tube to achieve administration to the patient. However, when configuring the medicine, manual grinding is time-consuming, which is particularly evident when there is a shortage of staff in the hospital, and during the process of collecting and transferring the medicine powder after manual grinding to the dissolving container, the problem of incomplete transfer of the medicine powder is prone to occur.

[0004] CN115337841A discloses a tumor internal medicine perfusion chemotherapy dispensing device, a dispensing box is arranged at the upper end of the stirring box, five feed ports are formed in the dispensing box, a feeding device is arranged above the feed ports, a stirring device is arranged in the stirring box, a mixing device is arranged at the side end of the stirring device in the stirring box, the tumor internal medicine perfusion chemotherapy dispensing device puts medicines into the stirring box through the five feeding devices on the dispensing box for stirring, which facilitates the mixing of many different medicines, the solid medicine formula can be put into the grinding device above the feed port, so as to be ground into powder and then enter the stirring box through the feed port, and the solid medicine formula can be put in after being ground, and the medicines entering through the five feed ports are stirred by the stirring device.

[0005] CN115253858A relates to an intelligent dispensing equipment, which comprises a table plate, two parallel slide rails are fixed on the upper side of the table plate, a controller is installed on the upper side of the table plate at the middle of one side, two slide rail vertical plates are fixed on the upper side of the table plate at both ends, a lead screw is rotatably connected between the two slide rail vertical plates, a servo motor is installed on one side of one of the slide rail vertical plates, the driving end of the servo motor is fixedly connected with one end of the lead screw, and a sliding plate is slidably connected with the outer sides of the two slide rails. The medicine liquid stirring mechanism can stir different medicine liquids in the dispensing tank, accelerate the mixing speed of the medicine liquid, and improve the dispensing efficiency. The medicine tablet grinding mechanism can drive the grinding hammer to move up and down continuously, and the grinding hammer can knock and grind the medicine tablets in the grinding tray to grind the medicine tablets into powder.

[0006] However, there are some problems in the current scenario of cutting pills or grinding the configuration of the medicine for nasal feeding. In actual medication process, often more than one tablet is involved, so the medication for the same patient needs to be crushed in multiple times, and the operation process of the medical staff is complicated. The tablet is often small, and slight deviation in manual cutting will bring great difference to the cutting result of the tablet, and thus affect the treatment effect. The medicine of the previous patient will be left in the mortar and will follow the grinding rod into the medicine of the next patient. The mixing of medicines with different prescriptions will affect the treatment effect of the patient, or even endanger the life safety of the patient. When configuring the nasal feeding medicine, it is often difficult to completely take out the ground medicine powder, resulting in a certain residue in the mortar, so that the medicine dosage is inaccurate, thereby reducing the treatment effect, and in some cases, it will have serious consequences to the patient. Therefore, the present scheme hopes to provide a medicine grinding and dissolving integrated device, which can simplify the grinding and dissolving process of multiple tablets to improve the operation efficiency; the grinding and dissolving process can be combined with intelligent control to realize the accuracy of the medicine dosage, especially for patients such as newborns or children whose medicine dosage must be strictly controlled; the medicine residue can also be removed based on the structure or method control to avoid the cross risk of medicines with different prescriptions, and the device can be combined with the nasal feeding part to guide the configured medicine into the nasal feeding part of the patient.

[0007] In addition, on the one hand, there are differences in the understanding of those skilled in the art; on the other hand, the applicant has studied a large number of literatures and patents when making the present invention, but due to the limited space, all the details and contents are not listed in detail, which does not mean that the present invention does not have these characteristics of the prior art. On the contrary, the present invention has all the characteristics of the prior art, and the applicant reserves the right to add relevant prior art in the background art. SUMMARY

[0008] In view of the deficiencies of the prior art, the present application provides a tablet grinding and dissolving device, comprising: a grinding part for grinding and processing tablet or granular medicine particles into nasal feeding medicine powder; a dissolving part for mixing the nasal feeding medicine powder and a solvent with a set volume into a nasal feeding medicine solution with a target concentration; a taking part for dispensing a target dose of the nasal feeding medicine solution from the dissolving part to a nasal feeding input pipeline and / or a storage container communicated with the nasal feeding input pipeline; the device is also provided with a flushing assembly for transferring the nasal feeding medicine powder from the grinding part to the dissolving part, wherein the flushing assembly performs multiple flushing on the grinding part in a way of distinguishing according to flushing parameters, and the flushing parameters at least include flushing volume.

[0009] Compared with the prior art transfer nasal feeding drug powder based on gravity, gas-driven or based on structural vibration, etc., the solvent used to configure the nasal feeding drug solution is used as the medium for transferring the nasal feeding drug powder in the application. The solvent obtains the initial kinetic energy of flushing the drug powder under the action of the flushing assembly. The solvent flushes the nasal feeding drug powder based on the solvent flow and the action of gravity into the dissolving part. Therefore, compared with the flushing based on wind power and the structural vibration, etc., the solvent flushing based on the application can effectively improve the efficiency and effectiveness of transferring the nasal feeding drug powder, that is, the solvent flushing based on the application can not only quickly transfer the nasal feeding drug powder, but also ensure that the nasal feeding drug powder can be completely transferred to the dissolving part, avoiding the adhesion and residue of the nasal feeding drug powder causing the deviation of the drug concentration or the cross contamination of the drug. When configuring the nasal feeding drug, since the nasal feeding process requires a lot of manual labor, if it is found that the amount of drug administration does not meet the predetermined dose in the conventional scheme, secondary nasal feeding needs to be organized, causing waste of labor. Therefore, when administering the drug, more attention needs to be paid to the accuracy of the dose of the drug. The complete transfer of the drug powder to the drug by using the solvent dissolving the drug powder in the scheme can significantly improve the dose accuracy of the nasal feeding drug, and significantly reduce the situation of supplementing the nasal feeding drug to the patient in the later stage. In addition, due to the absorption and blocking effect of the nasal feeding drug powder on the solvent, the flushing assembly often has difficulty in achieving the ideal flushing effect by performing single flushing. The flushing assembly of the application performs multiple flushing, and the nasal feeding drug solution flowing with the subsequent batch of nasal feeding drug powder can flow relative to the nasal feeding drug solution existing in the dissolving part. The vortex and bubbles generated by the relative flow can increase the contact area of the nasal feeding drug powder and the solvent, thereby assisting the stirring device to improve the dissolution speed and quality of the nasal feeding drug powder.

[0010] Preferably, the dissolving part is also configured with a stirring assembly for accelerating the dissolution of the nasal feeding drug powder in the solvent, wherein the stirring assembly is arranged to stir in a direction opposite to the flow direction of the nasal feeding drug solution carrying the nasal feeding drug powder into the dissolving part.

[0011] In the scheme, in order to fully mix the nasal feeding drug powder and the solvent, the momentum of the liquid flow carrying the drug powder into the dissolving part is also utilized. The stirring assembly is controlled to rotate in a direction substantially opposite to the direction of the liquid flow into the dissolving part. The solution that has entered the dissolving part can be driven by the stirring assembly to move in a direction opposite to the direction of the solution entering the dissolving part, so that the two liquid flows collide with each other near the entrance of the dissolving part, thereby making the nasal feeding drug powder dissolve more quickly and efficiently, significantly reducing the situation that the nasal feeding drug powder is not dissolved, and significantly improving the efficiency of the stirring and dissolving configuration drug.

[0012] Preferably, the grinding part has a medicine outlet for transferring the nasal feeding medicine powder to the dissolving part, the medicine outlet is communicated to the dissolving part, and the medicine outlet is arranged in an axial direction at an angle with the rotation direction of the stirring assembly, and the angle is less than 90 degrees.

[0013] Preferably, the flushing assembly comprises a first nozzle, a second nozzle and a third nozzle, the first nozzle provides the solvent for driving the flow of the nasal feeding medicine powder, the second nozzle is arranged in a spiral manner in the axial and circumferential directions to form an annular cavity surrounding the internal space in the grinding part, and the third nozzle is arranged at the medicine outlet of the grinding part to enhance the flow speed of the solvent and the nasal feeding medicine powder wrapped by the solvent and ensure the flow efficiency.

[0014] The stirring assembly is arranged opposite to or at an obtuse angle with the flow direction of the solvent into the dissolving part, which can effectively improve the flow intensity of the nasal feeding medicine solution in the dissolving part and the action intensity of the nasal feeding medicine solution on the stirring assembly, thereby improving the dissolution speed of the nasal feeding medicine powder and ensuring that all the nasal feeding medicine powder can be dissolved in the solvent, avoiding the deposition of the nasal feeding medicine powder due to incomplete dissolution, inaccurate drug concentration or blockage of the drug administration channel (nasal feeding pipeline, infusion pipeline, etc.). The nasal feeding pipeline is generally relatively narrow, and it can only pass part of the liquid food or solution type medicine. If the nasal feeding medicine powder is not fully dissolved but forms a suspension or turbidity in the solution, it is likely that the nasal feeding medicine will adhere to the nasal feeding pipeline during the process of nasal feeding of the patient, causing blockage or poor flow of the nasal feeding pipeline, which has a great impact on the patient. The nasal feeding pipeline can be regarded as one of the life support conditions of the patient. If the nasal feeding pipeline is not smooth, the patient will have difficulty in obtaining the required medicine, food and water, which can easily lead to the deterioration of the patient's condition. Therefore, the above-mentioned scheme of the stirring assembly is designed to have the stirring direction opposite to the direction of the solution into the dissolving part, which can release the kinetic energy generated by the liquid flow collision to disperse the nasal feeding medicine powder and accelerate the dissolution of the nasal feeding medicine powder, thereby significantly reducing the probability of blockage of the nasal feeding pipeline and improving the safety of the patient using the nasal feeding pipeline. Further, the nasal feeding pipeline is generally not disassembled. When the nasal feeding medicine is applied to the patient, especially when the nasal feeding medicine is applied to the patient multiple times, the conventional scheme is manually configured in a unified manner each time, and the adhered nasal feeding medicine in the nasal feeding pipeline will inevitably occur, resulting in a serious shortage of the actual drug dose. In the present scheme, the number of flushing times is determined according to the type of medicine, especially in relation to the solubility and adhesion degree of the medicine, so that the present scheme can intelligently adjust the amount of solvent for flushing according to the parameters related to the adhesion of the medicine, thereby significantly reducing the adhesion of the medicine in the nasal feeding pipeline by using multiple flushing while ensuring the accuracy of the total drug dose.

[0015] Preferably, the first, second and third spray heads are capable of adjusting the flushing parameters respectively to perform the flushing in stages, wherein, when performing the flushing in subsequent rounds, the three spray heads are capable of adjusting the flushing angle based on the adjustment of the selected flushing range, so that targeted flushing can be performed for the residual nasogastric drug powder.

[0016] Preferably, an intelligent part for controlling the grinding and dissolving access process is further configured, before the drug particles are placed into the grinding part, the intelligent part is based on the acquired drug configuration information, the input information of the operator, the intelligent part is based on the preset rules, and whether one or more of the input information and / or the drug configuration information conforms to the preset rules is checked.

[0017] The identification and verification of the intelligent part for the nasogastric drug configuration information can assist the operator in identifying and verifying the nasogastric drug, including the confirmation and verification of the information such as the nasogastric drug category, the nasogastric drug particle quality, the nasogastric drug suitable population, the suitable concentration, etc. Some information is automatically identified, and some information can be set by the operator, so that the intelligent part can perform safety verification based on the preset rules on the nasogastric drug particle quality, the preset concentration, and the capacity calculated from the nasogastric drug particle quality and the preset concentration, to ensure that the nasogastric drug category, the amount and the configuration information are correct and accurate, and then the next grinding and dissolving operation is performed. The intelligent part can also help the operator to automatically control and adjust, which can save operation time on the basis of improving operation precision, and can ensure the convenience of using the device to improve the efficiency of nasogastric drug configuration.

[0018] Preferably, the intelligent part determines the grinding time and grinding gear of the grinding part based on the drug category and drug particle quality in the drug configuration information, wherein the grinding gear is at least set differently based on the difference in grinding speed and / or grinding accuracy.

[0019] For different shapes and sizes of drug particles and drug categories determined by the dissolving characteristics, several grinding gears and grinding times at each gear can be set to ensure the grinding effect and improve the dissolving efficiency and quality of the nasogastric drug powder.

[0020] Preferably, in the case that the dissolving part is configured with a solvent of a preset capacity, the intelligent part controls the flushing capacity of the flushing assembly to be set in a way of decreasing step by step, wherein the sum of the flushing capacities of several times and the preset capacity of the solvent is equal to the set capacity of the solvent. The solvent of the preset capacity is introduced into the inside of the dissolving part before flushing, the purpose is to provide a wet environment in advance to the inside of the dissolving part to prevent the drug powder from adhering to the wall after entering the dissolving part. The set capacity is the total amount of solvent capacity that can be used according to the dose requirement after the final configuration of the drug (for example, according to the concentration standard). Then the sum of the flushing capacities for flushing multiple times and the preset capacity introduced into the grinding part before flushing should be equal to the set capacity.

[0021] The flushing capacity is large first and small later, which conforms to the change rule of the powder storage amount of the nasal feeding medicine in the grinding part, and all the powder of the nasal feeding medicine can be transferred to the dissolving part based on multiple flushing.

[0022] Preferably, in the case that the flow component is arranged in the taking part and the communication state between the dissolving part and the nasal feeding input pipeline or the storage container communicated with the nasal feeding input pipeline is changed based on the control of the intelligent part, the intelligent part controls the taking part to dispense the target dose of the nasal feeding medicine solution in the manner that the intelligent part controls the taking part to dispense the target dose of the nasal feeding medicine solution based on one or more of the following: the change information of the liquid level of the dissolving part, the change information of the scale of the nasal feeding input pipeline or the storage container communicated with the nasal feeding input pipeline, and the measurement information of the flow component of the taking part. In order to ensure the accuracy of the medicine amount, the present application adopts the target dose of the nasal feeding medicine solution corresponding to the medicine amount instead of the way of dividing the medicine particles, which can effectively improve the accuracy of the medicine amount, especially for the patient groups such as newborns or children whose medicine amount needs to be strictly controlled. The target dose can be measured or verified in multiple ways, for example, the flow component with the highest accuracy is used as the controller of the target dose. The present scheme can directly guide the configured nasal feeding medicine into the components related to nasal feeding, such as the nasal feeding input pipeline (nasal feeding tube) mentioned above or the storage container communicated with the nasal feeding input pipeline, that is, the present scheme can provide an integrated device for nasal feeding medicine from medicine grinding, medicine transfer, medicine dissolving, medicine preparation to nasal feeding administration. The process can be automatically performed without human intervention, which significantly reduces the labor cost and ensures the sufficient grinding, complete transfer and accurate dose of the medicine.

[0023] Preferably, the cleaning component for drying and disinfection is further arranged, and in the case that the flushing component can clean the nasal feeding medicine powder or the nasal feeding medicine solution remaining in the grinding part, the dissolving part and the taking part based on the flow of the solvent, the cleaning component performs drying and disinfection on the grinding part, the dissolving part and the taking part based on the flow of the gas and the ultraviolet irradiation.

[0024] The cleaning component and the flushing component can cooperate to clean the device, including multiple measures such as flushing, drying, purging and disinfection, so as to ensure that the device does not have medicine residues to avoid medicine cross, and the medicine concentration and the medicine amount are not affected by the remaining solid and liquid. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 is the overall structure schematic diagram of the device provided by the present application;

[0026] Figure 2 is the functional connection schematic diagram of the device of the present application.

[0027] LIST OF REFERENCE NUMERALS

[0028] 100: grinding part;

[0029] 200: dissolving part; 201: rinsing assembly; 202: stirring assembly; 203: cleaning assembly;

[0030] 300: taking part; 301: flow assembly;

[0031] 400: intelligent part; 401: grinding control unit; 402: rinsing and cleaning unit; 403: dosage control unit; 404: identification verification unit. DETAILED DESCRIPTION

[0032] The present application will be described in detail below with reference to the accompanying drawings. Figure 1 And 2 will be described in detail.

[0033] In the scenario where the patient needs to be administered, for example, in the hospital scene, or in the scene of patient care, drug configuration is a common type of work. Due to the differences in individual patient conditions, it may be necessary to split the standard drug dosage into a more micro drug dosage according to the doctor's order or the drug instructions. Commonly, for example, a tablet or pill is cut into 1 / 8, 1 / 16, or even 1 / 20. Since the existing tablet splitting is difficult to accurately cut the tablet, the drug is ground into powder and configured into a solution containing the corresponding amount of drug using a solvent, and then the solution is provided to the patient. On the other hand, there are also scenarios that directly require flexible drug dispensing for patients, often requiring medical staff or dispensers to weigh the required amount of drug, grind it into powder, and then add the appropriate solvent to make the target drug. However, in the current scenario of splitting pills or grinding and configuring drug agents, there are some problems. In the actual medication process, often more than one tablet is involved, so for the same patient, the tablet needs to be crushed multiple times, and the operation process for medical staff is tedious. The tablet is often very small, and a slight deviation in manual cutting will greatly affect the tablet cutting result, thereby affecting the treatment effect. The drug for the previous patient may be left in the mortar and then enter the drug for the next patient with the grinding rod. Mixing of drugs with different prescriptions may affect the treatment effect of the patient, or even endanger the life safety of the patient. When configuring the drug, it is often difficult to completely remove the ground drug powder, resulting in some residue remaining in the mortar, which makes the drug dosage inaccurate, thereby reducing the treatment effect, and in some cases, it may have serious consequences for the patient. Therefore, the present scheme hopes to provide a drug grinding, dissolving, and taking integrated device that can simplify the grinding and dissolving process of multiple tablets to improve operational efficiency; the grinding, dissolving, and taking process can be combined with intelligent control to achieve the accuracy of the drug dosage, especially for patient groups such as newborns or children whose drug dosage must be strictly controlled; and drug residues can be removed based on structural settings or method control to avoid the risk of mixing drugs with different prescriptions.

[0034] Based on this, the scheme proposes a tablet grinding and dissolving device, which at least includes a grinding part, a dissolving part and a taking part. The grinding part is used to grind the tablet or granular medicine into nasal feeding medicine powder. In other embodiments, the medicine which is originally powder or the medicine which is originally powder and is agglomerated during storage can also be put into the grinding part for grinding processing. The dissolving part is operatively attached to the grinding part to receive the ground medicine from the grinding part and combine with the corresponding solvent to configure the medicine into the required medicine solution with a certain target medicine concentration and the required medicine concentration for the corresponding patient. The taking part is used to guide the target dose of medicine solution from the dissolving part and distribute it to the nasal feeding input pipeline and / or storage container. In order to minimize the transfer steps of the nasal feeding medicine powder and the nasal feeding medicine solution and the transfer accuracy during the transfer process, the grinding, dispensing and other functions are integrated in this application, which can improve the medicine configuration efficiency and also ensure the medicine configuration accuracy. Preferably, for the medicine which still needs to be cut, the scheme also includes a medicine cutting part which is arranged upstream of the grinding part, i.e. its outlet is communicated to the medicine inlet of the grinding part. The medicine cutting part includes a cutting assembly, a bearing assembly and a moving assembly, and also includes an inlet for medicine and an outlet for medicine. The bearing assembly is generally a platform structure which is used to bear the medicine. Further, the bearing assembly is configured with a limiting unit which can limit the movement freedom of the medicine in the horizontal direction. A plurality of types of limiting units can be arranged on the bearing assembly according to various possible shapes and sizes of the medicine required in advance, so that various shapes and sizes of the medicine can be limited in the corresponding limiting unit. The types of medicine which can be configured for nasal feeding are limited and the variety is relatively small, so a plurality of limiting units can be arranged on the bearing assembly in advance according to the types of medicine. When the medicine is put in through the inlet, the operator opens the inlet and places the medicine in the limiting unit corresponding to the type of medicine. The inlet can be a cover structure which can be opened to expose the bearing assembly inside and the limiting unit on the bearing assembly. In another embodiment, a variable shape limiting unit can also be configured, for example, a limiting unit composed of a plurality of individually controllable limiting pieces. When it is necessary to change the shape of the limiting unit, the limiting pieces can be controlled to change the angle and relative relationship of each limiting piece to obtain a limiting unit of different shape. The above control can be automatically performed by a computer, for example, after the medicine type is obtained through image recognition, the limiting pieces are automatically adjusted based on the preset control scheme to form the corresponding limiting unit. The cutting assembly is generally a knife structure which can be moved above the medicine limited in the limiting unit and is driven to apply a pressure cutting force downward to separate the medicine. Preferably, the cutting assembly includes an image acquisition unit which acquires the shape of the medicine to enable the control unit of the cutting assembly to determine the contact position of the cutting based on the shape of the medicine and the preset cutting target. The preset cutting target can be input by the operator to the medicine cutting part from the outside, for example, inputting the instruction to cut half.The control unit of the cutting assembly internally models the shape of the medicine (only the two-dimensional shape of the projection plane needs to be established), and determines the contact position of the cutting based on the cutting target. For example, under the condition of cutting the cutting target into two equal parts, the control unit of the cutting assembly determines the contact position as the line of symmetry of the medicine model. Preferably, the cutter part of the cutting assembly can have multiple preset cutters to choose from. For example, a circular medicine (most of the medicine is circular) can be equally cut into two, three, or five parts by a cutter. After obtaining the cutting target, the control unit of the cutting assembly can select the corresponding cutter based on the cutting target. A relatively simple alternative is that the cutting assembly is configured with multiple types of cutters placed on the bearing assembly. As described above, the cutters can be pre-configured to cut multiple types of medicines for multiple cutting targets. After the operator places the medicine in the limiting unit, the corresponding cutter is manually selected to cut the medicine. Since there is a limiting unit and a corresponding cutter, as long as the size relationship between the cutter and the limiting unit is pre-configured, the operator can manually cut the medicine to ensure accuracy. The moving assembly is configured to move the cut medicine to the outlet as needed so that the medicine can enter the grinding part. For example, the moving assembly is configured as a mechanical arm with image acquisition function, which can identify the cut medicine subpart and control the mechanical arm to grab the medicine subpart and send it into the outlet. A simple alternative is that the step of moving the medicine is replaced by manual operation. Then a prompt unit is provided on the medicine cutting part, which can prompt the completion of medicine cutting.

[0035] The grinding part 100 includes a medicine inlet, a grinding unit, and a medicine outlet.

[0036] The grinding unit can be composed of a moving assembly and a static assembly. The moving assembly is connected with a driving structure, so that the moving assembly can grind based on the movement relative to the static assembly. The driving assembly can be a motor device. For example, the central axis of the grinding unit can be arranged in the horizontal direction. The moving assembly and the static assembly are coaxially arranged as a cylindrical roller and a cylindrical cavity with an annular cavity. The inspected medicine particles enter the annular cavity between the moving assembly and the static assembly of the grinding unit from the medicine inlet. The static assembly can be provided with a plurality of screen holes on the circumferential wall surface. The screen holes are arranged close to the medicine outlet of the grinding part 100. During the movement of the moving assembly relative to the static assembly and the grinding process, the medicine particles move along the central axis of the grinding unit. The cross-sectional size of the annular cavity decreases along the central axis, so that the medicine particles are gradually refined until they fall into the medicine outlet of the grinding part 100 through the screen holes. Alternatively, the moving assembly of the grinding unit is configured as a plurality of roller groups. Each group of rollers is arranged opposite to each other and has a grinding gap between them. A plurality of roller groups are sequentially arranged along the central axis of the grinding unit, and the grinding gaps are arranged in decreasing order along the central axis. The medicine enters the grinding unit from the medicine inlet and is ground layer by layer to form a nasal feeding medicine powder with the required fineness, and then passes through the screen to enter the medicine outlet. Preferably, there is a certain medicine powder accommodation space between the screen and the medicine outlet.

[0037] Preferably, the smart part is further configured to acquire drug configuration information, input information and preset rules. The drug configuration information is the information of the drug to be put into the drug inlet, which at least includes drug category, drug particle size, drug particle mass, etc. For finished drugs, such as commercial drugs, the dosage form, size and mass are relatively fixed, so only the drug category identification code needs to be acquired to obtain the remaining drug configuration information in the database. Generally, the drug category identification code can be realized by using the drug commodity two-dimensional code. Alternatively, in some embodiments, an internal identification code is prepared for each drug in the hospital, and the smart part can acquire the drug category identification code by scanning the code, i.e. using a bar code reading device to acquire the identification code on the drug packaging box, so that the smart part can acquire the corresponding remaining drug configuration information in the networked database. The input information is the information manually input by the operator responsible for operating the device, which can include drug category, drug particle size, drug set concentration and drug administration object information. The input information can be manually input by the operator in the case where the drug does not have a category identification code, and additionally includes drug set concentration information, which can be used as a reference standard for the device to configure the corresponding drug in the subsequent process. In addition, the drug administration object information in the input information is the supply object of this drug dispensing, i.e. the patient receiving the drug. The drug administration object information can be the identity information of the patient, such as the patient's identity code. Based on the acquired drug administration object information, the smart part can acquire the preset rules associated with the object information from the database, which include drug specifications, drug suitable population, drug suitable concentration, etc. The preset rules can be uploaded by the patient's diagnosing doctor, which records the patient's drug suitable category (i.e. drug specifications) and suitable amount (i.e. drug suitable concentration), etc. After acquiring the preset rules, the smart part compares whether one or more of the input information and / or the drug configuration information conforms to the preset rules, and if it conforms, the further operation permission is opened to the operator, and if it does not conform, the operator is prompted. For example, the smart part queries the preset rules from the database to obtain the drug specifications as A drug, and then compares whether the drug category in the drug configuration information or the input information is A drug, and if it is, it conforms. The further operation permission can be the start permission of the device, or when the drug inlet is configured with an electrically controlled opening and closing structure, the permission is the permission to open the drug inlet.

[0038] Preferably, the smart part is communicatively coupled with the grinding part, so that the grinding part is capable of configuring its working parameters based on at least one control instruction transmitted by the smart part, wherein the control instruction is derived based on one or more of the drug configuration information, the input information and the preset rules acquired by the smart part. In detail, the grinding gear and the grinding time of the grinding part can be electrically controlled to be adjusted, and based on the control instruction sent by the smart part, the corresponding working parameters of the grinding part can be selected. The smart part comprises a grinding control unit, which further determines the grinding time and the grinding gear of the grinding part based on the drug specification information in the preset rules, in the case that the result of the smart part checking whether one or more of the input information and / or the drug configuration information conforms to the preset rules is that the one or more conforms to the preset rules. The specific determination method can be realized by a pre-prepared comparison table preset in the smart part or a database that can be queried by the smart part. The comparison table is formulated according to prior knowledge and includes drug specifications and corresponding grinding time and grinding gear. The drug specification information at least includes drug type, size, mass and other information. The grinding gear can be set differently based on the grinding speed and / or the grinding accuracy. The grinding time and the grinding gear of the drug are determined according to the size of the mass of the drug particles and the grinding requirements corresponding to the drug category, so that the drug particles can be processed into the required nasogastric feeding drug powder.

[0039] Preferably, the dissolving part is connected to the grinding part. Preferably, the dissolving part is operatively attached to the grinding part. Preferably, the dissolving part is connected to the grinding part in a manner that enables the application of flushing fluid to the grinding part. Preferably, the dissolving part is also capable of collecting flushing fluid that has passed through the grinding part. Preferably, the dissolving part is also capable of being connected to the grinding part in a manner that enables dry cleaning of the grinding part. In one embodiment, the dissolving part 200 is configured with a dissolving container, a flushing assembly 201 for outputting solvent to the grinding part 100 and the dissolving part 200, a cleaning assembly 203 for dry cleaning of the grinding part 100 and the dissolving part 200, and a stirring assembly 202 for stirring treatment of the nasogastric drug solution in the dissolving container. Specifically, the dissolving container is connected to the medicine outlet of the grinding part 100 through an inlet with a controllable communication state, so that the nasogastric drug powder can enter the dissolving container of the dissolving part 200 through the inlet, the stirring assembly 202 of the dissolving part 200 is coaxially arranged with the dissolving container, so that the stirring assembly can perform stirring operation on the nasogastric drug solution in the dissolving container, the stirring speed and direction of the stirring assembly 202 are controlled by the flushing and cleaning unit 402 of the intelligent part 400, and the dissolving container is provided with an outlet at the bottom for connecting to the taking part 300. To ensure that the dissolving container can completely discharge the nasogastric drug solution, the dissolving container is arranged in a manner that the bottom has the outlet position as the lowest point. To enhance the relative flow degree of the nasogastric drug solution to improve the dissolution speed of the nasogastric drug powder, the connection position of the inlet of the dissolving part 200 and the dissolving container is arranged in a manner that the axial direction of the inlet is perpendicular to the radial direction of the dissolving container. Preferably, the axial direction of the inlet is arranged at an angle less than 90° with the radial direction of the dissolving container, so that the nasogastric drug powder and solution entering the dissolving container through the inlet can produce stronger relative flow with the nasogastric drug solution existing in the dissolving container. The above-mentioned inlet can be the medicine outlet of the grinding part. Preferably, the above-mentioned angle is selected to be in the range of 30°-45°, within which range the momentum component of the solution flowing in through the inlet and the solution in the dissolving container in the circumferential direction of the dissolving container has the relatively largest relative value, so that the two solution flows can produce the relatively largest mutual impact at the position where the inlet and the dissolving container meet, so that the solutes in the two solution flows can be further mixed, dissolved and uniform. Preferably, the stirring assembly is configured with structure and / or working parameters that enable the liquid flow in the dissolving container driven by the stirring assembly to have opposite momentum in the circumferential direction of the dissolving container to the liquid flow entering through the inlet, for example, selection of forward rotation or reverse rotation, and configuration of corresponding structure of stirring blades. This scheme can further mix the prepared liquid, so that the prepared liquid can be more uniform.

[0040] The dissolving process based on the above structure includes:

[0041] The flushing process: after the grinding is completed, the flushing cleaning unit 402 of the intelligent part 400 controls the flushing assembly 201 to release the solvent stored in the flushing assembly 201 to the grinding part 100 and / or the dissolving part 200, so that the nasogastric drug powder can be brought into the dissolving part 200 under the action of the solvent, wherein the type of solvent is selected based on the purpose of dispensing, so that the solvent used to flush the nasogastric drug powder can be further mixed with the nasogastric drug powder in the dissolving part to cooperate to form the target drug. Specifically, the flushing assembly 201 is provided with a plurality of flushing nozzles at the grinding part 100, and the flushing nozzles are arranged in the dissolving part 200 in a manner capable of driving the nasogastric drug powder to move from the grinding part 100 inlet to the grinding part 100 outlet. For example, a first nozzle is arranged at the inlet of the grinding part 100 to provide a solvent for driving the flow of nasogastric drug powder; a plurality of second nozzles are arranged at the grinding unit, and the plurality of second nozzles are arranged in a spiral manner in the axial and circumferential directions, that is, the plurality of second nozzles are located at different axial positions and different circumferential angles of the grinding unit, so that the solvent released by the plurality of second nozzles can surround and cover the annular cavity between the moving assembly and the static assembly of the grinding unit; a third nozzle is arranged at the outlet of the grinding part 100 to enhance the flow speed and ensure the flow efficiency of the solvent and the nasogastric drug powder entrained by the solvent. The above embodiment is mainly aimed at the grinding scene of the drug that does not need to be screened by the screen, or the scene of cleaning the grinding part as a whole, so as to realize the flushing of the nasogastric drug powder in the whole grinding part into the dissolving part, so that the drug ingredients can enter the dissolving part to the greatest extent. In another embodiment, the grinding part is provided with a screen to filter the drug powder meeting the target fineness, so that the required drug powder falls into the outlet position. In this case, the flushing assembly can be arranged only in the space between the screen and the outlet, that is, the third nozzle described above, to flush the required drug powder to the dissolving part.

[0042] In order to ensure that the nasogastric drug powder in the grinding part 100 can be completely transferred to the dissolving part 200 to ensure the accuracy of the drug configuration, the flushing cleaning unit 402 of the intelligent part 400 controls the flushing assembly 201 to perform multiple flushing on the grinding part 100, which can be performed by adjusting the flushing parameters of the first nozzle to the third nozzle. The flushing parameters can include flushing capacity, flushing flow, flushing pressure, etc. For example, the first flushing action can take away most of the nasogastric drug powder, and only part of the corner has adhered nasogastric drug powder residue. The second flushing action can flush away the adhered nasogastric drug powder based on the adjustment of the flushing parameters, and the third flushing action can flush away the nasogastric drug powder located at the edge or flow angle area based on the adjustment of the flushing range, so as to ensure that the nasogastric drug powder in the grinding part 100 can be completely transferred to the dissolving part 200, while improving the transfer speed.

[0043] Stirring process: in order to cooperate with the flushing process of the flushing assembly 201, the stirring assembly 202 can be operated at the beginning of the flushing process, so that the nasogastric drug solution entraining the nasogastric drug powder flow can flow relative to the stirring assembly 202, and the contact area of the nasogastric drug powder and the solvent can be increased based on the vortex and bubbles generated by the relative flow, thereby assisting the stirring device to improve the dissolution speed and quality of the nasogastric drug powder. Alternatively, before the flushing process starts, the flushing assembly 201 releases a preset volume of solvent into the dissolution container, so that the nasogastric drug solution entraining the nasogastric drug powder flow can flow relative to the solvent driven by the stirring assembly 202, and the stirring direction in the stirring assembly is opposite to the direction of the nasogastric drug solution flowing from the inlet into the dissolution container, so that the flushing process and the stirring process can be carried out at the same time, which can significantly increase the dissolution speed and quality of the nasogastric drug powder.

[0044] The above scheme realizes direct flushing of the powder in the grinding part with the solvent related to the preparation of the drug. First, the scheme is different from the scheme that requires manual transfer of the ground drug powder to the dissolution link, which can prevent incomplete transfer of the nasogastric drug powder, or contamination or loss of the nasogastric drug powder during the impurity transfer process. Second, the scheme is different from the scheme that directly uses gravity to send the ground drug powder into the dissolution component by simply installing a powder collection dissolution component below the grinding device. Such a scheme is prone to have nasogastric drug powder remaining at the connection between the grinding and dissolution components, resulting in a drug concentration that does not meet the requirements, and a reduced drug effect. The present scheme directly uses the solvent for preparing the drug to flush the nasogastric drug powder in the grinding part, which utilizes the similar compatibility principle of the corresponding solvent and the nasogastric drug powder, can dissolve most of the nasogastric drug powder at the first time of contact of the fast-flowing solvent to the nasogastric drug powder, and directly form a mixture of the solvent and the nasogastric drug powder after flushing, which further enters the stirring in the dissolution part, and finally directly forms the target drug without additional impurity removal work. Compared with direct flushing with water, this can omit the step of removing excess water; compared with using air flow for blowing, since the solvent used not only can move the drug powder, but also has stronger dissolution performance, it can better deal with drug residues.

[0045] Preferably, the present solution also takes into account the following problem: compared with direct blowing with gas flow, using solvent to flush the drug powder can drive more drug powder into the dissolving part, but also easily causes part of the nasogastric drug powder remaining in the drug outlet to form clumps and increase in adhesion due to being wetted by the solvent, causing this part of the clumped drug to adhere near the drug outlet. Such clumped drug is more difficult to flush. The drug that is prone to clumping is usually the drug residue near the wall surface of the drug outlet, because it itself contacts the wall surface of the drug outlet before flushing. After being wetted by the solvent, it is easy to form clumped drug based on the wall surface, and then adhere to the wall surface of the drug outlet. If the clumped drug is to be flushed with the solvent, the following problems exist: clumped drug generally appears in large quantities during the first flushing, and in order to ensure that as much nasogastric drug powder as possible is flushed into the dissolving part during the first flushing, the amount of solvent used during the first flushing is greater than that of subsequent flushing rounds, and may even account for more than 80%. Due to the target concentration limit of the target drug, the amount of solvent used for flushing is limited, and it needs to be less than or equal to the amount of solvent required for the preparation of the target drug. If it is greater, it will cause the concentration of the target drug to decrease and result in a failed drug preparation. Therefore, when a large amount of clumped drug is produced during the first flushing, if the remaining solvent quota is used to flush the clumped drug in the subsequent flushing rounds, on the one hand, the remaining amount of solvent is not enough, making it difficult to flush sufficiently; on the other hand, if the exit flow rate of the solvent needs to be increased to increase the impact of the solvent, it will cause the solvent to flow too fast, making it difficult to achieve comprehensive flushing of the drug residue. Moreover, if the clumped drug is to be precisely flushed, the location of the clumped drug also needs to be grasped, which leads to the need for additional installation of image detection components and other detection components, which undoubtedly increases a large amount of cost.

[0046] Therefore, based on the above, the present scheme gives a preferred embodiment, the medicine outlet of the grinding part is configured in an angle with the circumferential direction of the dissolution container in its axial direction, and the stirring assembly in the dissolution container is configured to drive the fluid in the dissolution container to flow in a circumferential direction around the dissolution container, and also has a controller which can at least control the opening of the flushing assembly and the stirring assembly, wherein the controller is configured to control the stirring assembly to open before the first flushing is ready to start after the grinding of the medicine is completed, and the stirring direction of the stirring assembly is configured to drive the fluid in the dissolution container in the opposite direction of the pointing direction of the medicine outlet, so that part of the fluid can enter above the medicine outlet under the lifting action of the channel of the medicine outlet. Subsequently, the controller controls the flushing assembly to start the first flushing. Preferably, the stirring assembly, when driving the fluid, can impart driving power to the fluid to rise in the dissolution container in addition to the driving power in the circumferential direction in the dissolution container based on the structure selection, so that the fluid can rise to the medicine outlet while rotating in the circumferential direction and be discharged from the other end of the medicine outlet. The dissolution container is preferably a barrel-shaped structure, in which case the medicine outlet can be configured as multiple, and the axial direction of each medicine outlet at its setting position is configured in the above-mentioned manner, so that a radial circular ring-shaped medicine outlet channel cluster can be formed as a whole. In this embodiment, there is no liquid solvent inside the dissolution container before the first flushing, so the fluid at this time is a gas, such as air. When the air is automatically injected along the medicine outlet towards the grinding part under the driving of the stirring assembly, the nasogastric medicine powder at the medicine outlet is blown up, so that most of the nasogastric medicine powder attached to the bottom wall of the medicine outlet is no longer adsorbed on the wall. At this time, the first flushing is carried out again, so that the solvent can quickly pass through the medicine outlet to occupy the wall space, so that the nasogastric medicine powder loses the basis of sticky adhesion, and then the number and area of the agglomerated medicine are significantly reduced, and the loss of the concentration of the configured medicine is also greatly reduced.The scheme does not introduce any other auxiliary components, only relies on the stirring assembly used in the subsequent stirring step and the special design of the medicine outlet channel, based on the design of the control process, so that the large reduction of the medicine group is realized, so that the solvent amount used for each flushing is not carefully designed, the program design cost, maintenance and management cost are significantly reduced, the solvent amount used for flushing is simple and easy to obtain, for example, the solvent can be directly given according to the predetermined rule, without additional detection components and additional calculation processing control program, the cost is significantly reduced, and the total amount of solvent is guaranteed to meet the drug preparation target, which will not cause the concentration of the prepared medicine to be too low or too high, resulting in that the medicine cannot be used or the drug effect is poor, further, the special design of the medicine outlet channel can form two fluid streams opposite to the stirring direction in the channel position in the subsequent flushing times to significantly increase the mixing effect of the medicine and the solvent, and through the solution flowing out of the medicine outlet, the residual medicine powder above the medicine outlet and in the channel can be continuously flushed during the gap of the flushing process.

[0047] As shown in Figure 1 The taking part 300 is configured with a storage container for storing the nasogastric feeding drug solution applied to the patient, which is communicated with the nasogastric feeding pipeline, so that the operator can transfer the target dose of the nasogastric feeding drug solution from the storage container communicated with the nasogastric feeding pipeline to the nasogastric feeding pipeline. The storage container communicated with the nasogastric feeding pipeline is connected with the dissolving part 200 based on the channel, and the flow component 301 can be arranged at the position close to the outlet of the dissolving container, which is used to control the communication state of the channel and can measure the volume of the nasogastric feeding drug solution flowing through the channel.

[0048] In the case that the taking part 300 is configured with the flow component 301 and changes the communication state of the storage container of the dissolving part 200 communicated with the nasogastric feeding pipeline based on the control of the intelligent part 400, the dose control unit 403 of the intelligent part 400 controls the taking part 300 to distribute the target dose of the nasogastric feeding drug solution in the manner of obtaining one or more of the liquid level change information of the dissolving part 200, the scale change information of the nasogastric feeding pipeline or the storage container communicated with the nasogastric feeding pipeline, and the flow component 301 measurement information of the taker.

[0049] After the above grinding, dissolving, taking, etc., the cleaning assembly 203 and the flushing assembly 201 can cooperate to clean the device, including flushing, drying, blowing, and disinfecting, etc., to ensure that the device does not have drug residues to avoid drug cross, and also to make the drug concentration and drug dosage not be affected by the residual solid and liquid. Specifically, the flushing assembly 201 can clean the nasal feeding drug powder or the nasal feeding drug solution remaining in the grinding part 100, the dissolving part 200, and the taking part 300 based on the flow of the solvent, and the cleaning assembly 203 can dry and disinfect the grinding part 100, the dissolving part 200, and the taking part 300 based on the flow of the gas and the ultraviolet irradiation.

[0050] It should be noted that the above specific embodiments are exemplary, and those skilled in the art can think of various solutions under the inspiration of the disclosure of the present application, and these solutions also belong to the disclosed range of the present application and fall within the protection scope of the present application. Those skilled in the art should understand that the present application specification and its drawings are illustrative and do not constitute a limitation on the claims. The protection scope of the present application is defined by the claims and their equivalents. The present application specification contains multiple inventive concepts, such as "preferably", "according to a preferred embodiment" or "optionally", which all indicate that the corresponding paragraph discloses an independent concept, and the applicant reserves the right to file a divisional application according to each inventive concept. Throughout the text, the features introduced by "preferably" are only optional ways, and should not be understood as necessarily set, therefore the applicant reserves the right to abandon or delete the relevant preferred features at any time.

Claims

1. A tablet grinding and dissolving device for preparing nasogastric medication, comprising: The grinding section (100) is used to grind flake or granular drug particles into nasal feeding drug powder; The dissolving section (200) is used to mix nasal feeding drug powder and a solvent of a set volume to form a nasal feeding drug solution with a target concentration; Dispensing section (300) for dispensing a target dose of nasogastric drug solution from the dissolving section (200) to the nasogastric inlet tube and / or a storage container connected to the nasogastric inlet tube; An intelligent unit (400) communicatively coupled to the grinding unit (100) is used to control the grinding, dissolving, and dispensing process. The device is characterized by further being equipped with a rinsing assembly (201) for transferring nasal feeding drug powder from the grinding section (100) to the dissolving section (200), wherein the rinsing assembly (201) performs multiple rinsings on the grinding section (100) at least according to the rinsing parameters being set differently, the rinsing parameters including at least the rinsing capacity, and when the dissolving section (200) is equipped with a solvent of a preset capacity, the rinsing capacity of the rinsing assembly (201) is set in a progressively decreasing manner under the control of the intelligent unit (400), and the sum of the multiple rinsing capacities and the preset capacity of the solvent is equal to the set capacity of the solvent; Before placing the drug particles into the grinding unit (100), the intelligent unit (400) acquires drug configuration information and operator input information. Based on preset rules, the intelligent unit (400) checks whether one or more of the input information and / or drug configuration information meet the preset rules. The drug configuration information includes drug category, drug particle size and drug particle mass information. The input information includes drug category, drug particle size, drug set concentration and drug application target information. Based on the acquired drug application target information, the intelligent unit (400) acquires preset rules associated with the target information from the database. The preset rules include drug specifications, drug applicable population and drug applicable concentration information. The grinding unit (100) configures its operating parameters based on the control instructions transmitted by the intelligent unit (400). The control instructions are derived by processing one or more of the drug preparation information, input information and preset rules obtained by the intelligent unit (400).

2. The apparatus according to claim 1, characterized in that, The dissolving section (200) is also equipped with a stirring assembly (202) for accelerating the dissolution of nasal feeding drug powder in a solvent. The stirring assembly (202) performs stirring in a manner in which the flow direction of the nasal feeding drug solution carrying the nasal feeding drug powder into the dissolving section (200) in portions is opposite to the flow direction of the nasal feeding drug solution driven by the stirring assembly (202).

3. The apparatus according to claim 2, characterized in that, The grinding section (100) has a dispensing port for transferring nasal feeding drug powder to the dissolving section (200), the dispensing port being connected to the dissolving section (200), and the axial direction of the dispensing port being configured at an angle less than 90° to the circumferential rotation direction of the stirring assembly (202).

4. The apparatus according to claim 1, characterized in that, The rinsing assembly (201) includes a first nozzle, a second nozzle, and a third nozzle. The first nozzle provides a solvent to drive the flow of nasal feeding drug powder. The second nozzle is arranged in a spiral configuration spaced apart in the axial and circumferential directions to form an annular cavity surrounding the internal space within the grinding section (100). The third nozzle is located at the drug outlet of the grinding section (100) to enhance the flow rate of the solvent and the nasal feeding drug powder encapsulated in the solvent and ensure flow efficiency.

5. The apparatus according to claim 4, characterized in that, The first, second, and third nozzles can each adjust the rinsing parameters to perform multiple rinsing cycles. During subsequent rinsing cycles, the three nozzles can adjust the rinsing angle based on the selected rinsing range to target and rinse any remaining nasal feeding medication powder.

6. The apparatus according to claim 5, characterized in that, The intelligent unit (400) determines the grinding time and grinding level of the grinding unit (100) based on the drug category and drug particle quality in the drug configuration information, wherein the grinding level is set differently based at least on the different grinding speed and / or grinding precision.

7. The apparatus according to claim 6, characterized in that, When the dispensing unit (300) is equipped with a flow component (301) and the communication state between the dissolving unit (200) and the nasogastric inlet pipe or the storage container connected to the nasogastric inlet pipe is changed based on the control of the intelligent unit (400), the intelligent unit (400) controls the dispensing unit (300) to dispense a target dose of nasogastric drug solution by acquiring one or more of the following: liquid level change information of the dissolving unit (200), scale change information of the nasogastric inlet pipe or the storage container connected to the nasogastric inlet pipe, and measurement information of the flow component (301) of the dispensing unit (300).

8. The apparatus according to claim 1, characterized in that, It is also equipped with a cleaning component (203) for drying and disinfection. When the rinsing component (201) can clean the nasal feeding drug powder or nasal feeding drug solution remaining in the grinding section (100), dissolving section (200) and dispensing section (300) based on the flow of solvent, the cleaning component (203) performs drying and disinfection on the grinding section (100), dissolving section (200) and dispensing section (300) based on gas flow and ultraviolet irradiation.

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