Method, device and equipment for determining corneal cross-linking irradiation position and storage medium

Abstract

Embodiments of the present application provide a method, device and equipment for determining corneal cross-linking irradiation position, and a storage medium. The method comprises: obtaining a corneal topographic image of a target object, and determining a corneal microelement surface according to the corneal topographic image; forming a projection microelement of the corneal microelement surface on a preset reference plane, and determining a correlation between each projection microelement in the projection microelement surface; and determining a corneal local cross-linking irradiation position according to the determined correlation. The present application determines the corneal microelement surface by obtaining the corneal topographic image of the target object, and determines the corneal local cross-linking irradiation position of the target object by the correlation between each projection microelement in the projection of the corneal microelement surface on the preset reference plane, so as to ensure the realization of the corneal local cross-linking by using a more accurate corneal local cross-linking irradiation position.

Description

Technical Field

[0001] This invention relates to the field of ophthalmic image processing technology, specifically to a method, apparatus, device, and storage medium for determining the corneal cross-linking irradiation position. Background Technology

[0002] Myopia is a condition caused by an excessively long axial length or relatively strong refractive power of the eye, resulting in blurred vision and decreased visual acuity when parallel light rays enter the eye and focus in front of the retina at rest. Current myopia correction techniques include optical correction, laser corneal refractive surgery, and implantable collamer lenses (ICL). Early-stage myopia (below 300 degrees) is often corrected using collagen cross-linking technology. Ultraviolet riboflavin collagen cross-linking (CXL) is a novel treatment method that uses riboflavin as a photosensitizer and ultraviolet light to mediate cross-linking of collagen fibers, improving mechanical rigidity and biomechanical stability, thereby preventing corneal ectasia and other diseases.

[0003] To achieve ultraviolet light-induced riboflavin-collagen crosslinking, the light source in relevant technical solutions uniformly irradiates the entire cornea to achieve crosslinking. This method struggles to precisely determine the irradiation location on the cornea, making it impossible to achieve localized corneal crosslinking and thus preventing the adjustment of specific parameters for each patient. Summary of the Invention

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the defect in the prior art that it is impossible to accurately determine the local cross-linking irradiation position of the cornea, thereby providing a method, device, equipment and storage medium for determining the corneal cross-linking irradiation position.

[0005] According to a first aspect, embodiments of the present invention provide a method for determining the location of corneal crosslinking irradiation, comprising: acquiring a corneal topographic image of a target object, and determining a corneal micro-element surface based on the corneal topographic image; forming a projection micro-element of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface, and determining the correlation relationship between each projection micro-element in the projection of the micro-element surface; and determining the location of local corneal crosslinking irradiation based on the determined correlation relationship.

[0006] Optionally, based on the corneal micro-element surface, a projection micro-element of the corneal micro-element surface on a preset reference plane is formed, and the correlation between each projection micro-element in the micro-element surface projection is determined, including: constructing a corneal micro-element surface function of the corneal micro-element surface in a preset reference coordinate system; determining the projection of the corneal micro-element surface on a preset reference plane of the preset reference coordinate system based on the corneal micro-element surface function, as the projection micro-element; and determining the projection relationship between each projection micro-element in the micro-element surface projection based on the projection relationship between the projection micro-element with respect to the z-axis and x-axis and z-axis and y-axis of the preset reference coordinate system.

[0007] Optionally, the location of localized corneal crosslinking irradiation can be determined using the following formula:

[0008] Z=∫∫ S Pdydz+Qdzdx+Rdxdy

[0009] Where Z represents the local cross-linking irradiation location of the cornea, dxdy, dydz, and dzdx represent projection micro-elements, Pdydz represents the area of ​​projection micro-element dydz, Qdzdx represents the area of ​​projection micro-element dzdx, and Rdxdy represents the area of ​​projection micro-element dxdy.

[0010] Optionally, the present invention provides a method for determining the corneal cross-linking irradiation location, which further includes: acquiring light source parameters and extracting corneal parameters of the target object based on a corneal topographic image; and determining irradiation adjustment parameters for irradiating the target object based on the corneal parameters, light source parameters, and the local corneal cross-linking irradiation location.

[0011] Optionally, the light source parameters include: irradiation time, radiant flux power, or the position of the maximum light intensity ring; the corneal parameters include: refractive power, and corneal thickness after the cornea has reacted through collagen cross-linking technology; the irradiation adjustment parameters are expressed by the following formula:

[0012]

[0013] Where f is the Lex function, used to characterize the irradiation adjustment parameters, T is the irradiation time, P is the radiation flux power, Th is the corneal thickness after the cornea reacts through collagen cross-linking technology, and D is the refractive power.

[0014] Optionally, based on corneal parameters, light source parameters, and the local cross-linking irradiation position of the cornea, irradiation adjustment parameters for irradiating the target object are determined, including: determining the position of the maximum light intensity ring according to the correspondence between the local cross-linking irradiation position of the cornea and the position of the maximum light intensity ring in the light source parameters; and determining the light source irradiation adjustment parameters according to the preset attenuation coefficient and the position of the maximum light intensity ring.

[0015] Optionally, the light source illumination adjustment parameters are determined based on the preset attenuation coefficient and the position of the maximum light intensity ring, including: determining the light source illumination adjustment parameters corresponding to the maximum light intensity ring based on the first preset attenuation coefficient and the position of the maximum light intensity ring; and / or, determining other light source illumination adjustment parameters besides the maximum light intensity ring based on the second preset attenuation coefficient and the position of the maximum light intensity ring.

[0016] According to a second aspect, embodiments of the present invention provide a device for determining the corneal crosslinking irradiation location, comprising: a micro-element surface determination unit configured to acquire a corneal topographic image of a target object and determine a corneal micro-element surface based on the corneal topographic image; an association relationship determination unit configured to form a projection micro-element of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface and determine the association relationship between each projection micro-element in the micro-element surface projection; and an irradiation location determination unit configured to determine the corneal local crosslinking irradiation location based on the determined association relationship.

[0017] According to a third aspect, embodiments of the present invention provide a non-transitory computer-readable storage medium storing computer instructions, which, when executed by a processor, implement the method for determining the corneal cross-linking irradiation position as described in any embodiment of the first aspect.

[0018] According to a fourth aspect, embodiments of the present invention provide a computer device including at least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions executable by the at least one processor, the instructions being executed by the at least one processor to perform the method for determining the corneal cross-linking irradiation location as described in any embodiment of the first aspect.

[0019] The technical solution of this invention has the following advantages:

[0020] This invention provides a method, apparatus, device, and storage medium for determining the location of corneal crosslinking irradiation. The method includes: acquiring a corneal topographic image of a target object and determining a corneal micro-element surface based on the corneal topographic image; forming projection micro-elements of the corneal micro-element surface onto a preset reference plane based on the corneal micro-element surface and determining the correlation between each projection micro-element in the projection of the micro-element surface; and determining the location of local corneal crosslinking irradiation based on the determined correlation. This invention determines the corneal micro-element surface by acquiring a corneal topographic image of the target object and, through the correlation between each projection micro-element in the projection formed by the corneal micro-element surface onto the preset reference plane, achieves the determination of the location of local corneal crosslinking irradiation of the target object, thereby ensuring the realization of local corneal crosslinking with a more accurate location of local corneal crosslinking irradiation. Attached Figure Description

[0021] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0022] Figure 1 This is a flowchart illustrating a specific example of the method for determining the corneal cross-linking irradiation location in Embodiment 1 of the present invention;

[0023] Figure 2 This is an analytical diagram illustrating a specific example of the method for determining the corneal cross-linking irradiation location in Embodiment 1 of the present invention;

[0024] Figure 3 This is an analytical diagram illustrating another specific example of the method for determining the corneal cross-linking irradiation location in Embodiment 1 of the present invention;

[0025] Figure 4 This is a structural example diagram of a specific example of the device for determining the corneal cross-linking irradiation position in Embodiment 2 of the present invention;

[0026] Figure 5 This is a structural example diagram of the computer device in Embodiment 4 of the present invention. Detailed Implementation

[0027] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0029] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can also refer to the internal connection of two components; and they can refer to a wireless connection or a wired connection. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0030] Furthermore, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0031] This embodiment provides a method for determining the location of corneal cross-linking irradiation, such as... Figure 1 As shown, Figure 1 This is a flowchart illustrating a specific example of a method for determining the corneal cross-linking irradiation location in an embodiment of the present invention, including:

[0032] S11: Obtain the corneal topography image of the target object and determine the corneal micro-element surface based on the corneal topography image.

[0033] Specifically, corneal topography images of the target object can be obtained through an eye-view analyzer or other means. The configuration of the eye-view analyzer and the acquisition of corneal topography images are relatively mature existing technologies, and will not be elaborated further.

[0034] The process of determining corneal micro-element surfaces based on corneal topographic images includes: determining corneal morphological parameters based on corneal topographic images; determining corneal protrusion regions based on the correspondence between the determined corneal morphological parameters and corneal protrusion regions; and constructing corneal micro-element surface functions based on corneal protrusion regions.

[0035] Specifically, determining corneal morphological parameters based on corneal topographic images refers to obtaining corneal morphological parameters by analyzing corneal topographic images. These corneal morphological parameters include one or more of the following: corneal surface variation index, vertical asymmetry index, keratoconus index, central keratoconus index, minimum radius of curvature, high asymmetry index, and high eccentricity index.

[0036] Specifically, based on the correspondence between the determined corneal morphological parameters and the corneal protrusion region, the corneal protrusion region is determined, and a corneal micro-element surface function is constructed based on the corneal protrusion region. This means taking the region in the corneal topographic image that matches the morphological parameters of the corneal protrusion region as the corneal protrusion region, and extracting the micro-element surface at the corresponding corneal protrusion region position.

[0037] For example, such as Figure 2 As shown, Figure 2This embodiment provides a specific example analysis diagram of a method for determining the corneal crosslinking irradiation location, including a corneal surface 21 and a corneal micro-element surface 22. The corneal surface 21 is a corneal surface transformed based on a corneal topographic image. The cut-off position of the corneal micro-element surface 22 is determined by the corneal convex region in the corneal topographic image.

[0038] S12: Based on the corneal micro-element surface, form the projection micro-element of the corneal micro-element surface on the preset reference plane, and determine the correlation between each projection micro-element in the micro-element surface projection.

[0039] Specifically, determining the correlation between the projected micro-elements in the micro-element surface projection refers to the partial derivative relationship between the projected micro-elements that form the corneal micro-element surface on the preset reference plane.

[0040] S13: Determine the location of local corneal crosslinking irradiation based on the established correlation.

[0041] This embodiment provides a method for determining the corneal crosslinking irradiation location, including: acquiring a corneal topographic image of a target object, and determining a corneal micro-element surface based on the corneal topographic image; forming projection micro-elements of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface, and determining the correlation between each projection micro-element in the projection of the micro-element surface; and determining the corneal local crosslinking irradiation location based on the determined correlation. This invention determines the corneal micro-element surface by acquiring a corneal topographic image of the target object, and achieves the determination of the corneal local crosslinking irradiation location of the target object through the correlation between each projection micro-element in the projection formed by the corneal micro-element surface on the preset reference plane, thereby ensuring the realization of corneal local crosslinking with a more accurate corneal local crosslinking irradiation location.

[0042] In an optional embodiment of the present invention, step S12 above, forming a projection micro-element of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface, and determining the correlation between each projection micro-element in the micro-element surface projection, includes:

[0043] (1) Construct the corneal micro-element surface function in the preset reference coordinate system.

[0044] Specifically, the preset reference coordinate system is a three-dimensional coordinate system consisting of the zero point, the x-axis, the y-axis, and the z-axis.

[0045] Specifically, the corneal micro-element surface function is expressed by the following formula:

[0046] dI=Pdydz+Qdzdx+Rdxdy

[0047] Where dI represents the corneal infinitesimal surface function, dxdy, dydz, and dzdx represent the projected infinitesimal elements, Pdydz represents the area of ​​the projected infinitesimal element dydz, Qdzdx represents the area of ​​the projected infinitesimal element dzdx, and Rdxdy represents the area of ​​the projected infinitesimal element dxdy.

[0048] (2) The projection of the corneal micro-element surface on the plane of the preset reference coordinate system is determined based on the corneal micro-element surface function, and is used as the projection micro-element.

[0049] For example, such as Figure 3 As shown, Figure 3 This is a specific example analysis diagram of a method for determining the corneal cross-linking irradiation site provided in this embodiment. Specifically, Figure 3 for Figure 2 A magnified view of the corneal micro-element surface 22, including projection micro-element 221, projection micro-element 222, and projection micro-element 223. Projection micro-element 221 represents projection micro-element dzdx, which is the projection of the corneal micro-element surface onto the preset coordinate system z0x plane; projection micro-element 222 represents projection micro-element dydz, which is the projection of the corneal micro-element surface onto the preset coordinate system y0z plane; and projection micro-element 223 represents projection micro-element dxdy, which is the projection of the corneal micro-element surface onto the preset coordinate system x0y plane.

[0050] (3) Based on the projection relationship between the projection elements and the z-axis and x-axis and the z-axis and y-axis of the projection elements with respect to the preset reference coordinate system, determine the projection relationship between each projection element in the projection of the surface.

[0051] Specifically, determining the projection relationship between the projection elements in the projection of the infinitesimal surface refers to determining the partial derivative relationship between the projection elements.

[0052] In practical applications, such as Figure 3 As shown, projection elements 221, 222, and 223 each share a common base, and the ratio of their areas is similar to the ratio of their heights. When the corneal surface rises along the x-axis, it correspondingly decreases along the z-axis; when the corneal surface rises along the y-axis, it correspondingly decreases along the z-axis. Therefore, the partial derivative of z with respect to x is negative, and the partial derivative of z with respect to y is also negative.

[0053] Specifically, the projection relationship between the projection elements in the projection of the infinitesimal surface is expressed by the following formula:

[0054]

[0055] in, Represents a differential element, z x Describing a microelement With micro elements The ratio of z y Describing a microelement With micro elements than.

[0056] In an optional embodiment of the present invention, in step S13 above, the corneal local crosslinking irradiation location is determined by the following formula:

[0057] Z=∫∫ s Pdydz+Qdzdx+Rdxdy=∫∫ s (-Pz x -Qz y +R)dxdy

[0058] Where Z represents the corneal local cross-linking irradiation site.

[0059] In an optional embodiment of the present invention, by acquiring a corneal topographic image of the target object, a corneal micro-element surface is cropped at the corresponding corneal protrusion area, and the partial derivative relationship of each projection micro-element in the projection formed by the corneal micro-element surface on a preset reference plane is used to determine the corneal local cross-linking irradiation position of the target object, thereby ensuring the realization of corneal local cross-linking with a more accurate corneal local cross-linking irradiation position.

[0060] In practical applications, during the ultraviolet light riboflavin-collagen cross-linking process, not only can specific parameters for patients be adjusted by determining the local cross-linking irradiation location of the cornea, but also by determining the irradiation adjustment parameters of the light source.

[0061] In an optional embodiment of the present invention, the method for determining the corneal crosslinking irradiation site provided in this embodiment further includes:

[0062] (1) Obtain the light source parameters and extract the corneal parameters of the target object based on the corneal topographic image.

[0063] Specifically, extracting corneal parameters from target objects based on corneal topography images is a relatively mature existing technology, and will not be elaborated further. Corneal parameters include: refractive power and corneal thickness resulting from the reaction after collagen cross-linking technology. The corneal thickness and refractive power resulting from the reaction after collagen cross-linking technology are obtained through corneal topography images. Obtaining light source parameters refers to determining the light source parameters based on the correspondence between the corneal thickness, refractive power, and localized cross-linking irradiation location after corneal cross-linking technology and preset light source parameters. Light source parameters include: irradiation time, radiant flux power, or the location of the maximum light intensity ring.

[0064] (2) Based on corneal parameters, light source parameters and corneal local cross-linking irradiation location, determine the irradiation adjustment parameters for irradiating the target object with light source.

[0065] In an optional embodiment of the present invention, the irradiation adjustment parameter in the above steps is expressed by the following formula:

[0066]

[0067] Where f is the Lex function, used to characterize the irradiation adjustment parameters, T is the irradiation time, P is the radiation flux power, Th is the corneal thickness after the cornea reacts through collagen cross-linking technology, and D is the refractive power.

[0068] Specifically, irradiation time is inversely proportional to radiative flux power. In the process of achieving riboflavin-collagen crosslinking under ultraviolet light, the longer the ultraviolet irradiation time, the lower the radiative flux power. The Löss function is a functional formula composed of irradiation adjustment parameters in ultraviolet riboflavin-collagen crosslinking.

[0069] For example, the irradiation adjustment parameters in the above embodiments can be represented as a corneal crosslinking parameter model. This model refers to determining ultraviolet riboflavin-collagen crosslinking parameters such as irradiation time, radiant flux power, corneal thickness after collagen crosslinking technology, and refractive power through the LOS function. The corneal crosslinking parameter model includes corneal parameters, light source parameters, and irradiation adjustment parameters. The corneal parameters in the model include: the location of local corneal crosslinking irradiation, the corneal thickness after collagen crosslinking technology, refractive power, or other corneal parameters. The light source parameters include: irradiation time, radiant flux power, or other relevant parameters. The irradiation adjustment parameter refers to the adjustment unit for controlling local corneal crosslinking irradiation; each unit of the irradiation adjustment parameter has corresponding irradiation time, radiant flux power, refractive power, corneal thickness after collagen crosslinking technology, and local corneal crosslinking irradiation location. In practical applications, each unit of the irradiation adjustment parameter can be called a LOS or other names. It should be understood that corneal crosslinking parameter models include, but are not limited to, the above formulas, as long as they can be used to determine the adjustment unit for local corneal crosslinking irradiation control based on corneal parameters and light source parameters, and apply the adjustment unit for local corneal crosslinking irradiation control to specific parameter adjustments for patients.

[0070] In an optional embodiment of the present invention, by acquiring the light source parameters and determining the adjustment unit for local corneal crosslinking irradiation control based on the corneal parameters, the light source parameters, and the local corneal crosslinking irradiation location, more precise local corneal crosslinking irradiation control can be achieved through the adjustment unit of local corneal crosslinking irradiation control, thereby enabling specific parameter adjustment for the patient.

[0071] In an optional embodiment of the present invention, the step of determining the irradiation adjustment parameters for irradiating the target object based on corneal parameters, light source parameters, and local corneal cross-linking irradiation locations includes:

[0072] (1) Determine the position of the maximum light intensity ring based on the correspondence between the local cross-linking irradiation position of the cornea and the position of the maximum light intensity ring in the light source parameters.

[0073] Specifically, in ultraviolet-based riboflavin-collagen crosslinking, the ultraviolet light source consists of multiple LEDs arranged in a ring within the irradiation instrument. The arrangement of the ultraviolet light source can be either a ring or a lobe. The position of the maximum light intensity ring refers to the ring position corresponding to the light source with the highest illumination intensity among the ultraviolet light sources. Based on the correspondence between the corneal local crosslinking irradiation position and the position of the maximum light intensity ring in the light source parameters, the maximum light intensity ring position is determined to be the position corresponding to the corneal local crosslinking irradiation position, where the illumination intensity of the ultraviolet light source corresponding to the corneal local crosslinking irradiation position is the highest among the ultraviolet light sources.

[0074] In practical applications, the corneal local crosslinking irradiation location corresponding to the ultraviolet light source with light intensity can be understood as the location where corneal local crosslinking irradiation is required. The light intensity required for the location where corneal local crosslinking irradiation is required can be different or the same, and can be controlled by a preset attenuation coefficient according to the actual situation. This application does not make specific limitations on this, as long as it can be used to reflect the ultraviolet light source intensity under the condition of preset attenuation coefficient.

[0075] (2) Determine the light source illumination adjustment parameters based on the preset attenuation coefficient and the position of the maximum light intensity ring.

[0076] Specifically, the preset attenuation coefficient includes a first preset attenuation coefficient and a second preset attenuation coefficient.

[0077] In an optional embodiment of the present invention, determining the light source illumination adjustment parameters based on the preset attenuation coefficient and the position of the maximum light intensity ring includes:

[0078] Based on the first preset attenuation coefficient and the position of the maximum light intensity ring, the light source illumination adjustment parameters corresponding to the maximum light intensity ring are determined.

[0079] Specifically, the first preset attenuation coefficient refers to the light intensity attenuation coefficient of the ultraviolet light source located at the position of the maximum light intensity ring. The first preset attenuation coefficient is used to control the light intensity of the ultraviolet light source corresponding to the position of the maximum light intensity ring.

[0080] As a variation of the above steps, determining the light source illumination adjustment parameters based on the preset attenuation coefficient and the position of the maximum light intensity ring may include:

[0081] Based on the second preset attenuation coefficient and the position of the maximum light intensity ring, determine the illumination adjustment parameters for other light sources besides the maximum light intensity ring.

[0082] Specifically, the second preset attenuation coefficient refers to the light intensity attenuation coefficient of other light sources besides the light source corresponding to the maximum light intensity ring. The second preset attenuation coefficient is used to control the light intensity of ultraviolet light sources other than the position of the maximum light intensity ring.

[0083] As a variation of the above steps, determining the light source illumination adjustment parameters based on the preset attenuation coefficient and the position of the maximum light intensity ring may include:

[0084] (1) Based on the first preset attenuation coefficient and the position of the maximum light intensity ring, determine the light source illumination adjustment parameters corresponding to the maximum light intensity ring. For details, please refer to the relevant descriptions in the above method embodiments regarding the determination of the light source illumination adjustment parameters corresponding to the maximum light intensity ring, which will not be repeated here.

[0085] (2) Based on the second preset attenuation coefficient and the position of the maximum light intensity ring, determine the illumination adjustment parameters for other light sources besides the maximum light intensity ring. For details, please refer to the relevant descriptions in the above method embodiments regarding the determination of illumination adjustment parameters for other light sources besides the maximum light intensity ring; these will not be repeated here.

[0086] Specifically, by controlling the first preset attenuation coefficient and the second preset attenuation coefficient, the light intensity of all ultraviolet light sources in the ultraviolet riboflavin collagen crosslinking is controlled.

[0087] In an optional embodiment of the present invention, the position of the maximum light intensity ring is determined based on the corneal local cross-linking irradiation position. The light intensity of each lamp source located in the maximum light intensity ring is controlled by a first preset attenuation coefficient corresponding to the position of the maximum light intensity ring, and the light intensity of each lamp source located outside the maximum light intensity ring is controlled by a second preset attenuation coefficient corresponding to the position of the maximum light intensity ring. Thus, by determining the corneal local cross-linking irradiation position and adjusting the light source irradiation parameters, more precise corneal local cross-linking irradiation control is achieved, thereby enabling specific parameter adjustments for patients.

[0088] This embodiment provides a device for determining the location of corneal cross-linking irradiation, such as... Figure 4 As shown, Figure 4 This is a structural example diagram of a corneal cross-linking irradiation position determination device provided in an embodiment of the present invention, including a micro-element curved surface determination unit 41, an association relationship determination unit 42, and an irradiation position determination unit 43.

[0089] The micro-element surface determination unit 41 is configured to acquire a corneal topographic image of the target object and determine a corneal micro-element surface based on the corneal topographic image. For details, please refer to the relevant description of step S11 in any of the above method embodiments, which will not be repeated here.

[0090] The association determination unit 42 is configured to form a projection micro-element of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface, and to determine the association relationship between each projection micro-element in the micro-element surface projection. For details, please refer to the relevant description of step S12 in any of the above method embodiments, which will not be repeated here.

[0091] The irradiation location determination unit 43 is configured to determine the corneal local crosslinking irradiation location based on the determined association relationship. For details, please refer to the relevant description of step S13 in any of the above method embodiments, which will not be repeated here.

[0092] This invention provides a device for determining the corneal crosslinking irradiation location, comprising: a micro-element surface determination unit configured to acquire a corneal topographic image of a target object and determine a corneal micro-element surface based on the corneal topographic image; an association relationship determination unit configured to form a projection micro-element of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface and determine the association relationship between each projection micro-element in the projection of the micro-element surface; and an irradiation location determination unit configured to determine the corneal local crosslinking irradiation location based on the determined association relationship. This invention determines the corneal micro-element surface by acquiring a corneal topographic image of the target object and, through the association relationship between each projection micro-element in the projection formed by the corneal micro-element surface on the preset reference plane, achieves the determination of the corneal local crosslinking irradiation location of the target object, thereby ensuring the realization of corneal local crosslinking with a more accurate corneal local crosslinking irradiation location.

[0093] An embodiment of the present invention also provides a non-transitory computer storage medium storing computer-executable instructions that can execute the methods described in any of the above-described method embodiments. The storage medium may be a magnetic disk, optical disk, read-only memory (ROM), random access memory (RAM), flash memory, hard disk drive (HDD), or solid-state drive (SSD), etc.; the storage medium may also include combinations of the above types of memory.

[0094] One embodiment of the present invention also provides a computer device, such as... Figure 5 As shown, Figure 5This is a schematic diagram of a computer device according to an optional embodiment of the present invention. The computer device may include at least one processor 41, at least one communication interface 42, at least one communication bus 43, and at least one memory 44. The communication interface 42 may include a display screen and a keyboard; optionally, the communication interface 42 may also include a standard wired interface or a wireless interface. The memory 44 may be high-speed RAM (Random Access Memory) or non-volatile memory, such as at least one disk storage device. Optionally, the memory 44 may also be at least one storage device located remotely from the aforementioned processor 41. The processor 41 may be combined with... Figure 4 The described apparatus has an application program stored in memory 44, and the processor 41 calls the program code stored in memory 44 to perform the steps of the method described in any of the above method embodiments.

[0095] The communication bus 43 can be a peripheral component interconnect (PCI) bus or an extended industry standard architecture (EISA) bus, etc. The communication bus 43 can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Figure 5 The bus is represented by a single thick line, but this does not mean that there is only one bus or one type of bus.

[0096] The memory 44 may include volatile memory, such as random-access memory (RAM); the memory may also include non-volatile memory, such as flash memory, hard disk drive (HDD) or solid-state drive (SSD); the memory 44 may also include a combination of the above types of memory.

[0097] The processor 41 can be a central processing unit (CPU), a network processor (NP), or a combination of CPU and NP.

[0098] The processor 41 may further include a hardware chip. This hardware chip may be an application-specific integrated circuit (ASIC), a programmable logic device (PLD), or a combination thereof. The PLD may be a complex programmable logic device (CPLD), a field-programmable gate array (FPGA), a generic array logic (GAL), or any combination thereof.

[0099] Optionally, the memory 44 is also used to store program instructions. The processor 41 can invoke the program instructions to implement the method described in any embodiment of the present invention.

[0100] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A method for determining the location of corneal cross-linking irradiation, characterized in that, include: Acquire a corneal topographic image of the target object, and determine the corneal micro-element surface based on the corneal topographic image; Based on the corneal micro-element surface, a projection micro-element of the corneal micro-element surface on a preset reference plane is formed, and the partial derivative relationship between each projection micro-element in the projection of the micro-element surface is determined. Based on the established partial derivative relationship, the location of local corneal crosslinking irradiation is determined.

2. The method for determining the corneal cross-linking irradiation site according to claim 1, characterized in that, The step of forming a projection element of the corneal micro-element surface onto a preset reference plane based on the corneal micro-element surface, and determining the partial derivative relationship between each projection element in the projection of the micro-element surface, includes: Construct the corneal micro-element surface function in the preset reference coordinate system; The projection of the corneal micro-element surface onto the preset reference plane of the preset reference coordinate system is determined based on the corneal micro-element surface function, and is used as the projection micro-element; Based on the projection relationship between the projected micro-element and the z-axis and the y-axis of the projected micro-element with respect to the preset reference coordinate system, the partial derivative relationship between each projected micro-element in the micro-element surface projection is determined.

3. The method for determining the corneal cross-linking irradiation site according to claim 1, characterized in that, The location of the localized corneal crosslinking irradiation is determined using the following formula: in, Z Indicates the location of localized corneal crosslinking irradiation. , , Represents the projected infinitesimal element. Represents the projected infinitesimal element area, Represents the projected infinitesimal element area, Represents the projected infinitesimal element The area.

4. The method for determining the corneal cross-linking irradiation site according to claim 1, characterized in that, After determining the corneal local crosslinking irradiation site based on the determined partial derivative relationship, the method further includes: Obtain light source parameters and extract corneal parameters of the target object based on the corneal topography image; Based on the corneal parameters, light source parameters, and local corneal cross-linking irradiation location, irradiation adjustment parameters for irradiating the target object are determined, and these irradiation adjustment parameters are expressed by the following formula: Where f is used to characterize the irradiation adjustment parameters, T is the irradiation time, P is the radiation flux power, Th is the corneal thickness after the cornea reacts through collagen cross-linking technology, and D is the refractive power.

5. The method for determining the corneal cross-linking irradiation site according to claim 4, characterized in that, The light source parameters include: irradiation time, radiant flux power, or the position of the maximum light intensity ring. The corneal parameters include: refractive power and corneal thickness resulting from the reaction after collagen cross-linking technology. The determination of irradiation adjustment parameters for the target object based on the corneal parameters, light source parameters, and the localized corneal cross-linking irradiation position includes: The position of the maximum light intensity ring is determined based on the correspondence between the local cross-linking irradiation position of the cornea and the position of the maximum light intensity ring in the light source parameters; The irradiation adjustment parameters are determined based on the preset attenuation coefficient and the position of the maximum light intensity ring.

6. The method for determining the corneal cross-linking irradiation site according to claim 5, characterized in that, The step of determining the illumination adjustment parameters based on the preset attenuation coefficient and the position of the maximum light intensity ring includes: Based on the first preset attenuation coefficient and the position of the maximum light intensity ring, determine the illumination adjustment parameters corresponding to the maximum light intensity ring; and / or, Based on the second preset attenuation coefficient and the position of the maximum light intensity ring, other irradiation adjustment parameters besides the maximum light intensity ring are determined.

7. A device for determining the location of corneal cross-linking irradiation, characterized in that, include: The micro-element surface determination unit is configured to acquire a corneal topography image of a target object and determine a corneal micro-element surface based on the corneal topography image; The correlation determination unit is configured to form a projection micro-element of the corneal micro-element surface on a preset reference plane based on the corneal micro-element surface, and determine the partial derivative relationship between each projection micro-element in the projection of the micro-element surface; The irradiation location determination unit is configured to determine the corneal local crosslinking irradiation location based on a determined partial derivative relationship.

8. A non-transitory computer-readable storage medium, characterized in that, The non-transitory computer-readable storage medium stores computer instructions that, when executed by a processor, implement the method for determining the corneal cross-linking irradiation location as described in any one of claims 1-6.

9. A computer device, characterized in that, include: At least one processor; And a memory communicatively connected to the at least one processor; wherein the memory stores instructions executable by the at least one processor, the instructions being executed by the at least one processor to perform the method for determining the corneal cross-linking irradiation location as described in any one of claims 1-6.

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