A Chinese medicine composition for treating secondary hyperparathyroidism and its preparation method

Abstract

The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating secondary hyperparathyroidism and a preparation method thereof. Specifically, it is prepared from the following components by mass: 20-26 parts of Cordyceps sinensis, 20-26 parts of Eucommia ulmoides, 18-22 parts of Gecko, 18-22 parts of Cuscuta australis, 15-19 parts of Achyranthes bidentata, 14-18 parts of Peach Kernel, 13-17 parts of Panax notoginseng, 10-14 parts of Olibanum, 10-14 parts of Schisandra chinensis, 8-12 parts of Lotus Seed, 8-12 parts of Licorice, and 4-8 parts of Mulberry. The Chinese medicine composition provided by the present invention has excellent therapeutic effect on secondary hyperparathyroidism, and the patient's blood phosphorus, blood calcium, PTH, Scr, BUN and other indicators are significantly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating secondary hyperparathyroidism and a preparation method thereof. Background Art

[0002] Secondary hyperparathyroidism (SHPT, referred to as secondary hyperparathyroidism) refers to a chronic compensatory clinical manifestation in which the parathyroid glands are stimulated by hypocalcemia, hypomagnesemia or hyperphosphatemia for a long time in conditions such as chronic renal insufficiency, intestinal malabsorption syndrome, Fanconi syndrome and renal tubular acidosis, vitamin D deficiency or resistance, pregnancy, lactation, etc., and secrete excessive PTH to increase blood calcium and magnesium and lower blood phosphorus. Long-term parathyroid hyperplasia eventually leads to the formation of autonomous adenomas.

[0003] The main clinical manifestations of secondary hyperparathyroidism caused by chronic renal failure (CRF) are:

[0004] Bone symptoms: Bone pain is spontaneous or aggravated by pressure. Bone pain is common in weight-bearing joints such as the spine, hips, and knees, and worsens during activity. The pain is paroxysmal or continuous, and may also be accompanied by pathological fractures and bone deformities.

[0005] Neurotoxicity and neuromuscular symptoms: The neurotoxic effect of PTH can cause mental disorders, electroencephalogram disorders and peripheral neuropathy, as well as proximal muscle weakness and muscle atrophy. The proximal muscle strength of the limbs progressively decreases, affecting upper limb lifting and walking.

[0006] Other symptoms related to high PTH, high blood calcium or metastatic calcification: varying degrees of skin itching and calcium deposition in the skin, soft tissue and blood vessel calcification, leading to ischemic necrosis, skin ischemic ulcers and muscle necrosis, mostly occurring at the tips of fingers and toes. Ectopic calcification occurs in the cornea, around joints, blood vessels, etc.

[0007] The existing treatment methods for secondary hyperparathyroidism are mainly dialysis therapy and surgical treatment. However, dialysis has great side effects, such as dialysis imbalance syndrome, allergies, muscle spasms, etc. Surgical treatment has high risks and is only suitable for patients with severe 2-HPT who cannot be controlled by medical treatment.

[0008] Therefore, how to provide a Chinese medicine composition for treating secondary hyperparathyroidism to make up for the technical problem of the lack of corresponding Chinese medicine treatment regimen for treating secondary hyperparathyroidism in the prior art is a problem that technical personnel in this field urgently need to solve. Summary of the invention

[0009] The purpose of the present invention is to provide a Chinese medicine composition for treating secondary hyperparathyroidism and a preparation method thereof.

[0010] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0011] The invention provides a traditional Chinese medicine composition for treating secondary hyperparathyroidism. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 20-26 parts of cordyceps sinensis, 20-26 parts of eucommia bark, 18-22 parts of gecko, 18-22 parts of dodder seeds, 15-19 parts of achyranthes bidentata, 14-18 parts of peach kernel, 13-17 parts of notoginseng, 10-14 parts of frankincense, 10-14 parts of schisandra chinensis, 8-12 parts of lotus seeds, 8-12 parts of liquorice and 4-8 parts of mulberries.

[0012] The present invention also provides a method for preparing the Chinese medicine composition for treating secondary hyperparathyroidism, comprising the following steps:

[0013] (1) Cordyceps sinensis, Eucommia ulmoides, Gecko, Cuscuta australis, Achyranthes bidentata, peach kernel, Panax notoginseng, frankincense, Schisandra chinensis, lotus seed, liquorice, and mulberry are mixed and ground to obtain material 1;

[0014] (2) mixing the material 1 obtained in step (1) with water for extraction, and filtering to obtain a filtrate 1 and a filter residue 1;

[0015] (3) mixing the filter residue 1 obtained in step (2) with water for a first decoction, and filtering to obtain a filtrate 2 and a filter residue 2;

[0016] (4) mixing the filter residue 2 obtained in step (3) with water for a second decoction, and filtering to obtain a filtrate 3;

[0017] (5) Mix filtrate 1, filtrate 2 and filtrate 3.

[0018] Preferably, the crushed material in step (1) is passed through a 65-75 mesh sieve, and the components under the sieve are collected as material 1.

[0019] Preferably, the mass ratio of the material 1 to water in step (2) is 1:5-7.

[0020] Preferably, the extraction temperature in step (2) is 50-60°C.

[0021] Preferably, the extraction time in step (2) is 2 to 4 hours.

[0022] Preferably, the first decoction time in step (3) is 3 to 5 hours.

[0023] Preferably, the mass ratio of the filter residue 1 to water in step (3) is 1:4-6.

[0024] Preferably, the second decoction time in step (4) is 2 to 3 hours.

[0025] Preferably, in step (4), the mass ratio of the filter residue 2 to water is 1:3-5.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. This prescription is based on tonifying the kidney, promoting blood circulation and removing blood stasis. Cordyceps sinensis, Eucommia ulmoides, Gecko, Cuscuta chinensis and mulberry in the prescription can tonify the kidney, promote blood circulation, nourish the liver, replenish essence and fill the marrow, nourish blood and nourish yin; Achyranthes bidentata and peach kernel can nourish blood and promote blood circulation, remove blood stasis and dredge collaterals; Schisandra chinensis and lotus seeds can nourish the kidney and consolidate essence, Panax notoginseng and frankincense can disperse blood stasis; Licorice can detoxify and harmonize various medicines; mulberry can mainly enter the liver and kidney, nourish yin and blood, promote body fluid and moisten dryness. The whole prescription plays the effects of tonifying the kidney and replenishing essence, replenishing blood and promoting blood circulation, and removing blood stasis. In addition, Cuscuta chinensis and mulberry added in the prescription of the present invention are all Chinese medicines containing high calcium and low phosphorus.

[0028] 2. The relationship between monarch, minister, adjuvant and envoy of the Chinese medicine formula of the present invention is as follows: monarch: Cordyceps sinensis, Eucommia ulmoides, Gecko and Cuscuta australis; minister: Achyranthes bidentata, peach kernel, Panax notoginseng and frankincense; adjuvant: Schisandra chinensis and lotus seed; envoy: Licorice and mulberry.

[0029] 3. The Chinese medicine composition provided by the present invention has an excellent therapeutic effect on secondary hyperparathyroidism, and the patient's blood phosphorus, blood calcium, PTH, Scr and BUN and other indicators are significantly improved. DETAILED DESCRIPTION

[0030] The invention provides a traditional Chinese medicine composition for treating secondary hyperparathyroidism, which is prepared from the following components by weight: 20-26 parts of cordyceps sinensis, 20-26 parts of eucommia bark, 18-22 parts of gecko, 18-22 parts of dodder seeds, 15-19 parts of achyranthes bidentata, 14-18 parts of peach kernel, 13-17 parts of notoginseng, 10-14 parts of frankincense, 10-14 parts of schisandra chinensis, 8-12 parts of lotus seeds, 8-12 parts of liquorice, and 4-8 parts of mulberries;

[0031] Preferably, the medicine is prepared from the following components in parts by weight: 21-25 parts of cordyceps sinensis, 21-25 parts of eucommia bark, 19-21 parts of gecko, 19-21 parts of dodder seeds, 16-18 parts of achyranthes bidentata, 15-17 parts of peach kernel, 14-16 parts of notoginseng, 11-13 parts of frankincense, 11-13 parts of schisandra chinensis, 9-11 parts of lotus seeds, 9-11 parts of liquorice, and 5-7 parts of mulberries;

[0032] It is further preferably prepared from the following components by weight: 22-24 parts of Cordyceps sinensis, 22-24 parts of Eucommia ulmoides, 20 parts of Gecko, 20 parts of Cuscuta australis, 17 parts of Achyranthes bidentata, 16 parts of peach kernel, 15 parts of Panax notoginseng, 12 parts of frankincense, 12 parts of Schisandra chinensis, 10 parts of lotus seeds, 10 parts of liquorice, and 6 parts of mulberries;

[0033] More preferably, it is prepared from the following components in parts by mass: 23 parts of Cordyceps sinensis, 23 parts of Eucommia ulmoides, 20 parts of Gecko, 20 parts of Cuscuta australis, 17 parts of Achyranthes bidentata, 16 parts of peach kernel, 15 parts of Panax notoginseng, 12 parts of frankincense, 12 parts of Schisandra chinensis, 10 parts of lotus seeds, 10 parts of liquorice, and 6 parts of mulberries.

[0034] The present invention also provides a method for preparing the Chinese medicine composition for treating secondary hyperparathyroidism, comprising the following steps:

[0035] (1) Cordyceps sinensis, Eucommia ulmoides, Gecko, Cuscuta australis, Achyranthes bidentata, peach kernel, Panax notoginseng, frankincense, Schisandra chinensis, lotus seed, liquorice, and mulberry are mixed and ground to obtain material 1;

[0036] (2) mixing the material 1 obtained in step (1) with water for extraction, and filtering to obtain a filtrate 1 and a filter residue 1;

[0037] (3) mixing the filter residue 1 obtained in step (2) with water for a first decoction, and filtering to obtain a filtrate 2 and a filter residue 2;

[0038] (4) mixing the filter residue 2 obtained in step (3) with water for a second decoction, and filtering to obtain a filtrate 3;

[0039] (5) Mix filtrate 1, filtrate 2 and filtrate 3.

[0040] In the present invention, the crushed material in step (1) is passed through a 65-75 mesh sieve, and the components under the sieve are collected as material 1; preferably 67-73 mesh; more preferably 69-71 mesh; and more preferably 70 mesh.

[0041] In the present invention, the mass ratio of the material 1 to water in step (2) is 1:5-7, preferably 1:6.

[0042] In the present invention, the extraction temperature in step (2) is 50-60°C; preferably 52-58°C; more preferably 54-56°C; and more preferably 55°C.

[0043] In the present invention, the extraction time in step (2) is 2 to 4 hours, preferably 3 hours.

[0044] In the present invention, the first decoction time in step (3) is 3 to 5 hours, preferably 4 hours.

[0045] In the present invention, the mass ratio of the filter residue 1 to water in step (3) is 1:4-6, preferably 1:5.

[0046] In the present invention, the second decoction time in step (4) is 2 to 3 hours, preferably 2.5 hours.

[0047] In the present invention, the mass ratio of the filter residue 2 to water in step (4) is 1:3-5, preferably 1:4.

[0048] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0049] Example 1

[0050] A method for preparing a traditional Chinese medicine composition for treating secondary hyperparathyroidism, comprising the following steps:

[0051] (1) 20 parts of Cordyceps sinensis, 20 parts of Eucommia ulmoides, 18 parts of Gecko, 18 parts of Cuscuta australis, 15 parts of Achyranthes bidentata, 14 parts of peach kernel, 13 parts of Panax notoginseng, 10 parts of frankincense, 10 parts of Schisandra chinensis, 8 parts of lotus seeds, 8 parts of liquorice, and 4 parts of mulberries were mixed and ground through a 65-mesh sieve, and the components under the sieve were collected as material 1;

[0052] (2) mixing the material 1 obtained in step (1) with water in a mass ratio of 1:5, leaching at 50° C. for 2 h, and filtering to obtain a filtrate 1 and a filter residue 1;

[0053] (3) mixing the filter residue 1 obtained in step (2) with water in a mass ratio of 1:4 and boiling for 3 hours, and filtering to obtain a filtrate 2 and a filter residue 2;

[0054] (4) mixing the filter residue 2 obtained in step (3) with water in a mass ratio of 1:3 and boiling for 2 h, and filtering to obtain a filtrate 3;

[0055] (5) Mix filtrate 1, filtrate 2 and filtrate 3.

[0056] Example 2

[0057] A method for preparing a traditional Chinese medicine composition for treating secondary hyperparathyroidism, comprising the following steps:

[0058] (1) 26 parts of Cordyceps sinensis, 26 parts of Eucommia ulmoides, 22 parts of Gecko, 22 parts of Cuscuta australis, 19 parts of Achyranthes bidentata, 18 parts of peach kernel, 17 parts of Panax notoginseng, 14 parts of frankincense, 14 parts of Schisandra chinensis, 12 parts of lotus seeds, 12 parts of Licorice, and 8 parts of mulberries were mixed and ground through a 75-mesh sieve, and the components under the sieve were collected as material 1;

[0059] (2) mixing the material 1 obtained in step (1) with water in a mass ratio of 1:7, leaching at 60° C. for 4 h, and filtering to obtain a filtrate 1 and a filter residue 1;

[0060] (3) mixing the filter residue 1 obtained in step (2) with water in a mass ratio of 1:6 and boiling for 5 hours, filtering to obtain a filtrate 2 and a filter residue 2;

[0061] (4) mixing the filter residue 2 obtained in step (3) with water in a mass ratio of 1:5 and boiling for 3 hours, and filtering to obtain a filtrate 3;

[0062] (5) Mix filtrate 1, filtrate 2 and filtrate 3.

[0063] Example 3

[0064] A method for preparing a traditional Chinese medicine composition for treating secondary hyperparathyroidism, comprising the following steps:

[0065] (1) 23 parts of Cordyceps sinensis, 23 parts of Eucommia ulmoides, 20 parts of Gecko, 20 parts of Cuscuta australis, 17 parts of Achyranthes bidentata, 16 parts of peach kernel, 15 parts of Panax notoginseng, 12 parts of frankincense, 12 parts of Schisandra chinensis, 10 parts of lotus seeds, 10 parts of Licorice, and 6 parts of mulberries were mixed and ground through a 70-mesh sieve, and the components under the sieve were collected as material 1;

[0066] (2) mixing the material 1 obtained in step (1) with water in a mass ratio of 1:6, leaching at 55° C. for 3 h, and filtering to obtain a filtrate 1 and a filter residue 1;

[0067] (3) mixing the filter residue 1 obtained in step (2) with water in a mass ratio of 1:5 and boiling for 4 hours, filtering to obtain a filtrate 2 and a filter residue 2;

[0068] (4) mixing the filter residue 2 obtained in step (3) with water in a mass ratio of 1:4 and boiling for 2.5 hours, and filtering to obtain a filtrate 3;

[0069] (5) Mix filtrate 1, filtrate 2 and filtrate 3.

[0070] Experimental Example 1

[0071] A total of 89 patients with non-dialysis chronic renal failure and secondary hyperparathyroidism were selected. The inclusion criteria were that all cases met the diagnostic criteria for CKD stages 2 to 4 established by the American Society of Nephrology.

[0072] The product obtained by the method of Example 3 was used as the experimental group; the method of administration was: 30 ml each time, twice a day.

[0073] Efficacy standard: refer to the Nephrology Branch of the Chinese Association of Traditional Chinese Medicine. Diagnosis, syndrome differentiation and efficacy evaluation of IgA nephropathy (trial program) [J]. 2007.

[0074] Significantly effective: (1) symptom and sign scores decreased by ≥70%; (2) Ser or BUN decreased by ≥15%.

[0075] Effective: (1) symptom and sign scores decreased by ≥30%; (2) Ser or BUN decreased by ≥5%.

[0076] Ineffectiveness: (1) symptom and sign scores decreased by <30%, (2) Ser or BUN decreased by <5%.

[0077] Among them, (1) is required and (2) is for reference.

[0078] The experiment lasted for 12 weeks. Various indicators of the patients were measured before and after the experiment, and the average values ​​were taken to determine the treatment effect. The experimental results are shown in Tables 1 and 2.

[0079] Table 1 Treatment effect statistics

[0080] Significant effect efficient invalid Experimental Group 71 12 6

[0081] Table 2 Test results of various indicators before the experiment

[0082]

[0083]

[0084] Table 3 Test results of various indicators after the experiment

[0085]

[0086]

[0087] It can be seen from the contents recorded in Table 1, Table 2 and Table 3 that the Chinese medicine composition for treating secondary hyperparathyroidism of the present invention has an excellent effect in treating secondary hyperparathyroidism, and the patient's blood phosphorus, blood calcium, PTH, Scr and BUN and other indicators are significantly improved.

[0088] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure, characterized in that: The invention is prepared from the following components in parts by weight: 20-26 parts of cordyceps sinensis, 20-26 parts of eucommia bark, 18-22 parts of gecko, 18-22 parts of dodder seeds, 15-19 parts of achyranthes bidentata, 14-18 parts of peach kernel, 13-17 parts of panax notoginseng, 10-14 parts of frankincense, 10-14 parts of schisandra chinensis, 8-12 parts of lotus seeds, 8-12 parts of liquorice and 4-8 parts of mulberries.

2. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 1, characterized in that: The steps include: (1) Cordyceps sinensis, Eucommia ulmoides, Gecko, Cuscuta australis, Achyranthes bidentata, peach kernel, Panax notoginseng, frankincense, Schisandra chinensis, lotus seed, liquorice and mulberry are mixed and ground to obtain material 1; (2) mixing the material 1 obtained in step (1) with water for extraction, and filtering to obtain a filtrate 1 and a filter residue 1; (3) mixing the filter residue 1 obtained in step (2) with water for a first decoction, and filtering to obtain a filtrate 2 and a filter residue 2; (4) mixing the filter residue 2 obtained in step (3) with water for a second decoction, and filtering to obtain a filtrate 3; (5) Mix filtrate 1, filtrate 2 and filtrate 3.

3. A method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: The crushed material in step (1) is passed through a 65-75 mesh sieve, and the components under the sieve are collected as material 1.

4. The method for preparing a Chinese medicine composition for treating secondary hyperparathyroidism due to chronic renal failure according to claim 2, characterized in that: In step (2), the mass ratio of material 1 to water is 1:5-7.

5. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: The extraction temperature in step (2) is 50-60°C.

6. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: The extraction time in step (2) is 2 to 4 hours.

7. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: The first decoction time in step (3) is 3 to 5 hours.

8. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: In step (3), the mass ratio of the filter residue 1 to water is 1:4-6.

9. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: The second decoction time in step (4) is 2 to 3 hours.

10. The method for preparing a Chinese medicine composition for treating hyperparathyroidism secondary to chronic renal failure according to claim 2, characterized in that: In step (4), the mass ratio of the filter residue 2 to water is 1:3-5.

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