A detergent for animals and a method for preparing the same

Abstract

The application provides an animal special detergent and a preparation method thereof, and belongs to the technical field of detergents. The animal special detergent is prepared from the following raw materials in parts by weight: solvent oil 20-40 parts, plant essential oil 2-3 parts, composite emulsifier 5-10 parts, deionized water 20-80 parts, stabilizer 1-5 parts and nano antibacterial mite-removing and stain-removing particles 5-10 parts. The composite emulsifier comprises a mixture of an anionic surfactant and a Gemini surfactant. The Gemini surfactant has the following structure: wherein R=C m H 2m+1 ; n=2-8; and m=12-18. The animal special detergent can effectively remove grease after fine skin oil tanning, has strong degreasing capacity, can quickly remove dust on the fur, makes the fur clean and smooth, is safe and environmentally friendly, is environment-friendly, has good antibacterial and mite-removing effects, has a pleasant smell, has good stability, and has a wide application prospect.

Description

TECHNICAL FIELD

[0001] The present application relates to the detergent technical field, specifically relates to a kind of animal special detergent and its preparation method. BACKGROUND

[0002] It is increasingly common for residents to keep animals at home. However, keeping animals can have adverse effects on our health and safety. Some zoonotic diseases can cause illness in humans through close contact between humans and animals. There are many zoonotic diseases, and their main pathogens include bacteria, viruses, fungi, rickettsia, mycoplasma, spirochetes, helminths, protozoa, and ectoparasites. These pathogens can cause diseases in animals, and then through close contact between humans and animals, they can be transmitted from infected animals to humans, causing human infection or illness. For example, rabies occurs every year, and its characteristics are long incubation period and high mortality. Diseases caused by bacteria include plague, anthrax, brucellosis, enterohemorrhagic E. coli O157 enteritis, tetanus, and others. Diseases caused by fungi include dermatophytosis and candidiasis, and diseases caused by parasites include trematodiasis and ascariasis, and ectoparasites include mites. Some people in households with animals often have skin allergies, frequent coughing, and even asthma. The occurrence of these diseases is often related to mites on animals. In addition, animals often lie on the ground, which easily attracts dust and various contaminants on the ground, including potentially contaminated pathogenic microorganisms. After animals defecate, the skin around the anus is also easily contaminated. Animals also easily carry contaminants on their feet after going outside. The secretion of sebaceous glands on animals' skin and fur easily sticks to the animals' skin and fur and emits a foul odor. Therefore, animals need regular bathing and grooming, as well as necessary sterilization and disinfection, to remove dust, contaminants, and odors from their fur, kill pathogenic microorganisms, maintain the cleanliness of their fur, and prevent the occurrence of infectious diseases. This can effectively prevent the spread of zoonotic infectious diseases, thereby protecting human health and safety.

[0003] Patent document CN108210350A discloses a special bathing liquid for pets, which comprises phase A: water, acrylate, sodium laureth sulfate, ethylene glycol distearate, cocamide MEA; phase B: polyquaternium-10, guar hydroxypropyltrimonium chloride, di-cocoyl ethyl hydroxyethyl methyl ammonium methyl sulfate, cocamidopropyl betaine, olive oil PEG-7 ester, sodium chloride, phase C: dimethicone, dimethiconol, amodimethicone, mink oil, DMDM hydantoin, triclosan, triethanolamine and fragrance. The bathing liquid can provide moisturizing effect, improve dry and wet combing properties and improve dry and wet smoothness, facilitate hair fluffing and combing, and has the functions of repairing hair damage, nourishing skin and hair, and preventing splitting and breaking. However, the silicon compounds such as dimethicone, dimethiconol and amodimethicone in the bathing liquid can make the hair smooth, but due to the water-insoluble nature of these silicon compounds, the silicon wrapped on the fur is not easy to be cleaned, especially the hair of dogs is not easy to be cleaned, and the long-term accumulation of these silicon compounds will make the hair gradually lose elasticity, block the pores and cause the hair follicles to gradually atrophy, and in severe cases, cause itching and hair loss. Therefore, the bathing liquid is not suitable for long-term and large-scale use of pet dogs.

[0004] Due to the solubility limit and the compatibility problem of surfactants, the variety and quantity of inorganic additives added to the liquid detergent are greatly affected. How to prepare a laundry liquid that is mild, safe, non-toxic, high-efficiency, low-foaming, and can wash, sterilize, and deodorize at the same time is still a difficult problem to be solved in the detergent industry. Moreover, the above patents are not pet sterilizing and deodorizing laundry liquids, and cannot effectively remove bacteria and odors. Therefore, there is a need in the market for a pet sterilizing and deodorizing detergent with the multiple functions of natural decontamination, sterilization, mite removal, and softening. Although some people in the industry have explored sterilizing and deodorizing laundry liquids, it is still of great significance to explore different formulations for pet and animal detergents. SUMMARY

[0005] The purpose of the present application is to provide an animal-specific detergent and a preparation method thereof, which has good anti-aging effect.

[0006] The technical solution of the present application is as follows:

[0007] The animal-specific detergent provided by the present application is prepared from the following raw materials in parts by weight: solvent oil 20-40 parts, plant essential oil 2-3 parts, composite emulsifier 5-10 parts, deionized water 20-80 parts, stabilizer 1-5 parts, and nano antibacterial mite-removing and decontaminating particles 5-10 parts.

[0008] The complex emulsifier comprises a mixture of an anionic surfactant and a Gemini surfactant; the structural formula of the Gemini surfactant is shown as formula I:

[0009]

[0010] Wherein, R = C m H 2m+1 ; n = 2-8; m = 12-18;

[0011] The nano-antibacterial mite-removing and stain-removing particles are polydopamine modified nano-hydroxyapatite with surface deposition of nano-silver and loading of plant source antibacterial agent;

[0012] The plant source antibacterial agent comprises berberine and baicalin.

[0013] As a further improvement of the present application, the preparation method of the nano-antibacterial mite-removing and stain-removing particles is as follows:

[0014] S1. Preparation of nano-hydroxyapatite: dissolve calcium salt in water, add acetamide to prepare a mixed solution, dissolve phosphate in water, drop the mixed solution, heat and stir to react, age, centrifuge, wash and dry to prepare nano-hydroxyapatite;

[0015] S2. Deposition of polydopamine: disperse the nano-hydroxyapatite prepared in step S1 in water, add dopamine hydrochloride and catalyst, heat and stir to react, centrifuge, wash and dry to prepare polydopamine modified hydroxyapatite;

[0016] S3. Preparation of plant source antibacterial agent: mix berberine and baicalin uniformly to prepare a plant source antibacterial agent;

[0017] S4. Preparation of nano-particles loaded with antibacterial agent: disperse the polydopamine modified hydroxyapatite prepared in step S2 in water, add the plant source antibacterial agent in step S3, stir to load, centrifuge, wash and dry to prepare nano-particles loaded with antibacterial agent;

[0018] S5. Deposition of nano-silver: dissolve glucose in water, add the nano-particles loaded with antibacterial agent prepared in step S4, drop silver ammine complex ion solution, heat and stir to react, centrifuge, wash and dry to prepare nano-antibacterial mite-removing and stain-removing particles.

[0019] As a further improvement of the present application, the calcium salt in step S1 is selected from at least one of calcium chloride and calcium nitrate, the phosphate is selected from at least one of sodium phosphate, potassium phosphate and ammonium phosphate, the mass ratio of the calcium salt, acetamide and phosphate is 18-22:25-35:10-15, the temperature of the heating and stirring reaction is 60-80℃, the time is 1-3h, and the aging time is 12-16h; in step S2, the mass ratio of the nano-hydroxyapatite, dopamine hydrochloride and catalyst is 10:12-15:0.2-0.3, the catalyst is a Tris-HCl solution with pH=5-6 containing 2-3wt% CoCl2, the temperature of the heating and stirring reaction is 40-50℃, and the time is 2-3h; in step S3, the mass ratio of the berberine and baicalin is 3-5:2.

[0020] As a further improvement of the present application, in step S4, the mass ratio of the polydopamine modified hydroxyapatite and the plant-derived antibacterial agent is 10:2-3, and the time of the stirring and loading is 20-30min; in step S5, the mass ratio of the glucose, the nanoparticle loaded with the antibacterial agent and the silver ammine complex ion solution is 3-5:10-12:7-10, the temperature of the heating and stirring reaction is 90-100℃, the time is 30-50min, and the silver ammine complex ion solution is prepared by adding 22-25wt% ammonia water dropwise into a 0.5-1mol / L silver nitrate solution until all the precipitates just disappear.

[0021] As a further improvement of the present application, the Gemini surfactant is prepared by the following method:

[0022] T1. The intermediate is prepared by the reaction of polyethylene glycol and chloroacetyl chloride, and the structure is as follows:

[0023] T2. The Gemini surfactant is prepared by the reaction of the intermediate and N,N-dimethylalkylamine.

[0024] As a further improvement of the present application, the structural formula of the polyethylene glycol in step T1 is as follows: wherein n=2-8, and the molar ratio of the polyethylene glycol and chloroacetyl chloride is 1:2-2.1; the structural formula of the N,N-dimethylalkylamine in step T2 is as follows: wherein R=C m H 2m+1 , m=12-18, and the molar ratio of the intermediate and N,N-dimethylalkylamine is 1:2-2.2.

[0025] As a further improvement of the present application, the specific reaction conditions are as follows:

[0026] T1. Dissolve 1 mole equivalent of polyethylene glycol and 3-5 mole equivalents of triethylamine in dichloromethane, add 2-2.1 mole equivalents of chloroacetyl chloride in dichloromethane, heat to 35-40℃, stir for 0.5-1h, precipitate with saturated sodium bicarbonate solution, recrystallize with ethanol, filter, wash, dry, and obtain the intermediate;

[0027] T2. Dissolve 1 mole equivalent of the intermediate and 3-5 mole equivalents of triethylamine in tetrahydrofuran, add 2-2.2 mole equivalents of N,N-dimethylalkylamine in tetrahydrofuran, heat to 50-60℃, stir for 1-2h, remove the solvent under reduced pressure, extract with water and diethyl ether, dry the diethyl ether layer, filter, remove the diethyl ether under reduced pressure, wash, and dry to obtain the Gemini surfactant.

[0028] As a further improvement of the present application, the anionic surfactant is selected from at least one of sodium dodecylbenzenesulfonate, sodium dodecyl sulfate, sodium dodecyl sulfonate, sodium tetradecylbenzenesulfonate, sodium tetradecyl sulfonate, sodium tetradecyl sulfate, sodium hexadecyl sulfonate, sodium hexadecylbenzenesulfonate, sodium hexadecyl sulfate, sodium octadecylbenzenesulfonate, sodium octadecyl sulfonate, and sodium octadecyl sulfate; the solvent oil is selected from at least one of petroleum solvent oil D60, odorless turpentine, dodecane, petroleum ether, and cyclohexane; the stabilizer is selected from at least one of 1,3-butanediol, 1,2-propanediol, 1,6-cyclohexanediol, and glycerol; and the plant essential oil is selected from at least one of tea tree essential oil, lavender essential oil, rosemary essential oil, lemon essential oil, clove essential oil, peppermint essential oil, cinnamon essential oil, and thyme essential oil.

[0029] As a further improvement of the present application, the composite emulsifier comprises a mixture of sodium hexadecylbenzenesulfonate and Gemini surfactant in a mass ratio of 2-3:7.

[0030] The present application further protects a preparation method of the above-mentioned animal special detergent, comprising the following steps:

[0031] (1) Heat the solvent oil to 50-60℃, add the composite emulsifier, plant essential oil, stabilizer, and nano antibacterial mite-killing and stain-removing particles, and stir to mix uniformly;

[0032] (2) Add deionized water while stirring, continue stirring for 20-30min, reduce to room temperature, discharge, and obtain the animal special detergent.

[0033] The animal special detergent has the following advantages: the animal special detergent of the application adds a composite emulsifier, which includes a mixture of an anionic surfactant and a Gemini surfactant, the Gemini surfactant refers to a surfactant with two hydrophilic groups and two hydrophobic groups, which is connected by a linking group through a chemical bond at the hydrophilic group or near the hydrophilic group, has strong aggregation ability, surface activity and interface adsorption capacity, has low critical micelle concentration and Krafft point, and has good solubilizing property, can be dissolved in cold water, has better calcium soap dispersibility, and has high efficient wetting performance, has good synergistic effect with the anionic surfactant, the system performance is more excellent, and has better water-solubilizing property and biological safety, etc. At the same time, the sulfonic acid group, sulfuric acid group or benzene sulfonic acid group of the anionic surfactant combines with calcium, magnesium, iron and other ions in water to form a precipitate during rinsing, so that the content of the surfactant adsorbed on the animal fur is very low during rinsing, the surface charge of the animal fur is low, the friction between the animal furs is increased when the animal furs are in contact, and the rinsing property is improved.

[0034] In addition, the composite emulsifier has good compounding effect with solvent oil, the solvent oil has good dissolving effect on some oil substances (substances secreted by sebaceous glands, the sebaceous glands of animals are generally developed, and the content of the oil substances secreted is high), and the oil is removed from the fur under the emulsification of the composite emulsifier, so that the effect of removing the oil odor and cleaning the fur is achieved. In addition, the plant essential oil added at the same time has good aromatic effect, good odor avoiding effect, and good antibacterial and acarid-killing effect.

[0035] The application further prepares a nano antibacterial and acarid-killing and decontaminating particle, the particle uses nano hydroxyapatite prepared by a precipitation method as a carrier, and a polydopamine layer is coated on the surface, so that the surface contains rich hydroxyl groups, amino groups and carboxyl groups, has good hydrogen bond adsorption effect on berberine and baicalin, meanwhile, the nano hydroxyapatite carrier has a porous structure, which can also promote the loading of the plant source antibacterial agent, so that the nano particle loads more antibacterial agents, meanwhile, the polydopamine layer has good hydrogen bond fixing effect on glucose, so as to promote the in-situ reaction of the nano silver on the surface of the nano particle, the nano silver generated in-situ on the surface has a small amount of Ag + , has excellent antibacterial performance, is safe and non-toxic, in addition, the amino structure on the polydopamine layer has a positive center, which also helps to adsorb small dust particles (with negative electricity) on the fur, so that the prepared nano antibacterial and acarid-killing and decontaminating particle has excellent antibacterial, acarid-killing and decontaminating effects, so that the animal detergent prepared by the application has good use safety and effectiveness.

[0036] Berberine and Baicalin are natural plant source antibacterial agents, which are safe, non-toxic side effects, and have high efficient antibacterial and acaricidal effects. Berberine has antibacterial effect on hemolytic streptococcus, staphylococcus aureus, gonococcus and frisch, shigella dysenteriae bacillus, and has different degrees of inhibition on tubercle bacillus, plague bacillus, and ameba bacteria, and has broad-spectrum antibacterial effect. Baicalin has a wide range of antibacterial effect, and has strong effect on staphylococcus aureus and green pyocyanin. Therefore, the combination of berberine and baicalin has synergistic effect, and has good inhibition and removal effect on animal fur mites.

[0037] The animal special detergent can effectively remove the oil after fine skin oil tanning, has strong degreasing ability, can quickly remove the dust on the fur, makes the fur clean and smooth, is safe and environmentally friendly, is environment-friendly, has good antibacterial and acaricidal effect, and has good stability and broad application prospect. BRIEF DESCRIPTION OF DRAWINGS

[0038] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and those skilled in the art can obtain other drawings according to these drawings without creative labor.

[0039] Figure 1 The synthesis route map of the Gemini surfactant of the present application. DETAILED DESCRIPTION

[0040] The technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only some embodiments of the present application, not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0041] Lemon essential oil, model 065465, peppermint essential oil, model 014, total alcohol content > 50, tea tree essential oil, model 519, purchased from Jian City Zhongxiang Natural Plant Co., Ltd.

[0042] Berberine, purity > 97%, Baicalin, purity > 85%, purchased from Xi'an Xiquan Biotechnology Co., Ltd.

[0043] Odorless turpentine oil, purchased from Shanghai Pendo Chemical Technology Co., Ltd.; petroleum solvent oil D60, purchased from Changzhou Langying Oil Product Chemical Co., Ltd.

[0044] Preparation example 1 preparation of Gemini surfactant

[0045] As Figure 1 , the method is as follows

[0046] T1. 0.1 mol of polyethylene glycol (PEG, n = 2) and 0.3 mol of triethylamine were dissolved in 100 mL of dichloromethane, 20 mL of a dichloromethane solution containing 0.2 mol of chloroacetyl chloride was added, heated to 35°C, stirred for 0.5 h, precipitated by adding an equal volume of saturated sodium bicarbonate solution, recrystallized with ethanol, filtered, washed with ethanol, and dried to obtain an intermediate;

[0047] T2. 0.1 mol of the intermediate and 0.3 mol of triethylamine were dissolved in 100 mL of tetrahydrofuran, 50 mL of a tetrahydrofuran solution containing 0.2 mol of N,N-dimethylalkylamine (R = C 12 H 25 ) was added, heated to 50°C, stirred for 1 h, the solvent was removed under reduced pressure, extracted with water and diethyl ether, the diethyl ether layer was dried, filtered, the diethyl ether was removed under reduced pressure, washed with diethyl ether, and dried to obtain a Gemini surfactant, the structure of which is as follows: ESI-MS calculated value: C 38 H 79 Cl2N2O5(M+H)+713.53, found: 713.6, yield 92%. NMR results: 1 H NMR (300 MHz, CDCl3) δ 4.25 (t, 4H), 4.21 (s, 4H), 3.65 (t, 4H), 3.32 (s, 12H), 3.25 (t, 4H), 1.72 (m, 4H), 1.32 (m, 4H), 1.30 (m, 36H), 0.97 (t, 6H).

[0048] Preparation of Gemini surfactant

[0049] As

[0050] , the method is as follows Figure 1

[0051] T1. 0.1 mol of polyethylene glycol (PEG, n = 2) and 0.5 mol of triethylamine were dissolved in 100 mL of dichloromethane, 20 mL of a dichloromethane solution containing 0.21 mol of chloroacetyl chloride was added, heated to 40°C, stirred for 1 h, precipitated by adding an equal volume of saturated sodium bicarbonate solution, recrystallized with ethanol, filtered, washed with ethanol, and dried to obtain an intermediate;

[0052] ​​​T2. Dissolve 0.1 mol of the intermediate and 0.5 mol of triethylamine in 100 mL of tetrahydrofuran, then add 50 mL of solution containing 0.22 mol of N,N-dimethylalkylamine. Where R = C 14 H 29 A solution of tetrahydrofuran was heated to 60°C and stirred for 2 hours. The solvent was removed under reduced pressure, and the mixture was extracted with water and diethyl ether. The ether layer was dried, filtered, and the diethyl ether was removed under reduced pressure. The mixture was washed with diethyl ether and dried to obtain the Gemini surfactant, the structure of which is as follows: ESI-MS calculated value: C 42 H 87 Cl2N2O5(M+H)+769.59, measured value: 769.6, yield: 90%.

[0053] MRI results: 1 H NMR (300MHz, CDCl3) δ 4.25 (t, 4H), 4.21 (s, 4H), 3.65 (t, 4H), 3.32 (s, 12H), 3.25 (t, 4H), 1.72 (m, 4H), 1.32 (m, 4H), 1.30 (m, 44H), 0.97 (t, 6H).

[0054] Preparation Example 3: Preparation of Gemini Surfactants

[0055] like Figure 1 The method is as follows:

[0056] T1. Add 0.1 mol of polyethylene glycol ( (n=4) and 0.4 mol triethylamine were dissolved in 100 mL of dichloromethane, and 20 mL of dichloromethane solution containing 0.205 mol chloroacetyl chloride was added. The mixture was heated to 37 °C and stirred for 1 h. An equal volume of saturated sodium bicarbonate solution was added to precipitate the product. The product was recrystallized with ethanol, filtered, washed with ethanol, and dried to obtain the intermediate.

[0057] T2. Dissolve 0.1 mol of the intermediate and 0.4 mol of triethylamine in 100 mL of tetrahydrofuran, then add 50 mL of solution containing 0.21 mol of N,N-dimethylalkylamine. Where R = C 12 H 25 A solution of tetrahydrofuran was heated to 55°C and stirred for 1.5 h. The solvent was removed under reduced pressure, and the mixture was extracted with water and diethyl ether. The ether layer was dried, filtered, and the diethyl ether was removed under reduced pressure. The mixture was washed with diethyl ether and dried to obtain the Gemini surfactant, with the following structure: ESI-MS calculated value: C 42 H 87 Cl2N2O5(M+H)+ 801.58, measured value: 801.6, yield: 89%.

[0058] NMR results: 1 H NMR (300 MHz, CDC13) δ 4.25 (t, 4H), 4.21 (s, 4H), 3.65 (t, 4H), 3.54 (m, 8H) 3.32 (s, 12H), 3.25 (t, 4H), 1.72 (m, 4H), 1.32 (m, 4H), 1.30 (m, 36H), 0.97 (t, 6H).

[0059] Preparation of nano-antibacterial, anti-mite and decontamination particles

[0060] The method is as follows:

[0061] S1. Preparation of nano-hydroxyapatite: 18 parts by weight of calcium chloride was dissolved in 50 parts by weight of water, 25 parts by weight of acetamide was added to prepare a mixed solution, 10 parts by weight of ammonium phosphate was dissolved in 100 parts by weight of water, the mixed solution was added dropwise, heated to 60°C, stirred for 1 h, aged for 12 h, centrifuged at 3000 r / min for 15 min, washed with water, and dried at 105°C for 1 h to prepare nano-hydroxyapatite;

[0062] S2. Deposition of polydopamine: 10 parts by weight of nano-hydroxyapatite prepared in step S1 was dispersed in water, 12 parts by weight of dopamine hydrochloride and 0.2 parts by weight of catalyst were added, heated to 40°C, stirred for 2 h, centrifuged at 3000 r / min for 15 min, washed with water, and dried at 105°C for 1 h to prepare polydopamine modified hydroxyapatite;

[0063] The catalyst is a Tris-HCl solution with pH = 5 containing 2wt% CoCl2;

[0064] S3. Preparation of plant-derived antibacterial agent: 3 parts by weight of berberine and 2 parts by weight of baicalin were stirred and mixed for 10 min to prepare a plant-derived antibacterial agent;

[0065] S4. Preparation of antibacterial agent loaded nanoparticles: 10 parts by weight of polydopamine modified hydroxyapatite prepared in step S2 was dispersed in 100 parts by weight of water, 2 parts by weight of plant-derived antibacterial agent in step S3 was added, stirred for 20 min, centrifuged at 3000 r / min for 15 min, washed with water, and dried at 105°C for 1 h to prepare antibacterial agent loaded nanoparticles;

[0066] S5. Nano-silver deposition: 3 parts by weight of glucose was dissolved in 100 parts by weight of water, 10 parts by weight of antibacterial agent loaded nanoparticles prepared in step S4 was added, 7 parts by weight of silver ammine complex ion solution was added dropwise, heated to 90°C, stirred for 30 min, centrifuged at 3000 r / min for 15 min, washed with water, and dried at 105°C for 1 h to prepare nano-antibacterial, anti-mite and decontamination particles;

[0067] The silver ammine complex ion solution is prepared as follows: 22wt% ammonia water is added dropwise into a 0.5mol / L silver nitrate solution until all the precipitate just disappears, to obtain the silver ammine complex ion solution.

[0068] Preparation of the nano-antibacterial mite-killing and stain-removing particles

[0069] The method is as follows:

[0070] S1. Preparation of the nano-hydroxyapatite: 22 parts by weight of calcium chloride is dissolved in 50 parts by weight of water, 35 parts by weight of acetamide is added to obtain a mixed solution, 15 parts by weight of potassium phosphate is dissolved in 100 parts by weight of water, the mixed solution is added dropwise, heated to 80℃, stirred for 3h, aged for 16h, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to obtain the nano-hydroxyapatite;

[0071] S2. Deposition of the polydopamine: 10 parts by weight of the nano-hydroxyapatite prepared in step S1 is dispersed in water, 15 parts by weight of dopamine hydrochloride and 0.3 parts by weight of a catalyst are added, heated to 50℃, stirred for 3h, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to obtain the polydopamine-modified hydroxyapatite;

[0072] The catalyst is a Tris-HCl solution containing 3wt% CoCl2 with pH=6;

[0073] S3. Preparation of the plant-derived antibacterial agent: 5 parts by weight of berberine and 2 parts by weight of baicalin are stirred and mixed for 10min to obtain the plant-derived antibacterial agent;

[0074] S4. Preparation of the antibacterial agent-loaded nanoparticles: 10 parts by weight of the polydopamine-modified hydroxyapatite prepared in step S2 is dispersed in 100 parts by weight of water, 3 parts by weight of the plant-derived antibacterial agent in step S3 is added, stirred for 30min, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to obtain the antibacterial agent-loaded nanoparticles;

[0075] S5. Deposition of the nano-silver: 5 parts by weight of glucose is dissolved in 100 parts by weight of water, 12 parts by weight of the antibacterial agent-loaded nanoparticles prepared in step S4 is added, 10 parts by weight of the silver ammine complex ion solution is added dropwise, heated to 100℃, stirred for 50min, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to obtain the nano-antibacterial mite-killing and stain-removing particles;

[0076] The silver ammine complex ion solution is prepared by adding 25wt% ammonia water into 1mol / L silver nitrate solution until all the precipitate just disappears.

[0077] Preparation of the nano-antibacterial and anti-mite and decontamination particles

[0078] The method is as follows:

[0079] S1. Preparation of nano-hydroxyapatite: 20 parts by weight of calcium nitrate was dissolved in 50 parts by weight of water, 30 parts by weight of acetamide was added to prepare a mixed solution, 12 parts by weight of sodium phosphate was dissolved in 100 parts by weight of water, the mixed solution was added dropwise, heated to 70℃, stirred for 2h, aged for 14h, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to prepare nano-hydroxyapatite;

[0080] S2. Deposition of polydopamine: 10 parts by weight of the nano-hydroxyapatite prepared in step S1 was dispersed in water, 13.5 parts by weight of dopamine hydrochloride and 0.25 parts by weight of catalyst were added, heated to 45℃, stirred for 2.5h, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to prepare polydopamine modified hydroxyapatite;

[0081] The catalyst is a Tris-HCl solution containing 2.5wt% CoCl2 with pH=5.5;

[0082] S3. Preparation of plant-derived antibacterial agent: 4 parts by weight of berberine and 2 parts by weight of baicalin were stirred and mixed for 10min to prepare a plant-derived antibacterial agent;

[0083] S4. Preparation of antibacterial agent loaded nanoparticles: 10 parts by weight of the polydopamine modified hydroxyapatite prepared in step S2 was dispersed in 100 parts by weight of water, 2.5 parts by weight of the plant-derived antibacterial agent in step S3 was added, stirred for 25min, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to prepare antibacterial agent loaded nanoparticles;

[0084] S5. Deposition of nano-silver: 4 parts by weight of glucose was dissolved in 100 parts by weight of water, 11 parts by weight of the antibacterial agent loaded nanoparticles prepared in step S4 was added, 8.5 parts by weight of silver ammine complex ion solution was added dropwise, heated to 95℃, stirred for 40min, centrifuged at 3000r / min for 15min, washed with water, and dried at 105℃ for 1h to prepare nano-antibacterial and anti-mite and decontamination particles;

[0085] The silver ammine complex ion solution is prepared by adding 25wt% ammonia water into 1mol / L silver nitrate solution until all the precipitate just disappears.

[0086] Comparative Preparation Example 1

[0087] The difference compared with Preparation Example 6 is that step S2 is not performed.

[0088] Comparative Preparation Example 2

[0089] The difference compared with Preparation Example 6 is that no berberine is added in step S3.

[0090] Comparative Preparation Example 3

[0091] The difference compared with Preparation Example 6 is that no baicalin is added in step S3.

[0092] Comparative Preparation Example 4

[0093] The difference compared with Preparation Example 6 is that step S3 and step S4 are not performed.

[0094] Comparative Preparation Example 5

[0095] The difference compared with Preparation Example 6 is that step S5 is not performed.

[0096] Example 1

[0097] Raw material composition (weight parts): petroleum ether 20 parts, peppermint essential oil 2 parts, composite emulsifier 5 parts, deionized water 20 parts, 1,2-propanediol 1 part, nano-antibacterial and mite-removing and stain-removing particles prepared in Preparation Example 4 5 parts.

[0098] The composite emulsifier comprises a mixture of sodium cetylbenzenesulfonate and Gemini surfactant prepared in Preparation Example 1, and the mass ratio is 2:7.

[0099] The preparation method comprises the following steps:

[0100] (1) heat the petroleum ether to 50℃, add the composite emulsifier, peppermint essential oil, 1,2-propanediol and nano-antibacterial and mite-removing and stain-removing particles, and stir to mix uniformly;

[0101] (2) add the deionized water while stirring, continue stirring for 20 min, reduce to room temperature, discharge, and prepare the animal special detergent.

[0102] Example 2

[0103] Raw material composition (weight parts): petroleum solvent oil D60 40 parts, tea tree essential oil 3 parts, composite emulsifier 10 parts, deionized water 80 parts, 1,6-cyclohexanediol 5 parts, nano-antibacterial and mite-removing and stain-removing particles prepared in Preparation Example 5 10 parts.

[0104] The complex emulsifier comprises a mixture of sodium hexadecyl benzene sulfonate and Gemini surfactant prepared in Preparation Example 2, with a mass ratio of 3:7.

[0105] The preparation method comprises the following steps:

[0106] (1) Heat petroleum solvent oil D60 to 60℃, add the complex emulsifier, tea tree oil, 1,6-cyclohexanediol, and nano antibacterial mite-killing and stain-removing particles, and mix uniformly under stirring;

[0107] (2) Add deionized water under stirring, continue stirring for 30 min, reduce to room temperature, discharge, and prepare the animal special detergent.

[0108] Example 3

[0109] Raw material composition (weight parts): odorless turpentine 30 parts, lemon essential oil 2.5 parts, complex emulsifier 7 parts, deionized water 50 parts, 1,3-butanediol 3 parts, and nano antibacterial mite-killing and stain-removing particles prepared in Preparation Example 6 7 parts.

[0110] The complex emulsifier comprises a mixture of sodium hexadecyl benzene sulfonate and Gemini surfactant prepared in Preparation Example 3, with a mass ratio of 2.5:7.

[0111] The preparation method comprises the following steps:

[0112] (1) Heat odorless turpentine to 55℃, add the complex emulsifier, lemon essential oil, 1,3-butanediol, and nano antibacterial mite-killing and stain-removing particles, and mix uniformly under stirring;

[0113] (2) Add deionized water under stirring, continue stirring for 25 min, reduce to room temperature, discharge, and prepare the animal special detergent.

[0114] Comparative Example 1

[0115] Compared with Example 3, the difference lies in that the complex emulsifier is single sodium hexadecyl benzene sulfonate.

[0116] Comparative Example 2

[0117] Compared with Example 3, the difference lies in that the complex emulsifier is single Gemini surfactant prepared in Preparation Example 3.

[0118] Comparative Example 3

[0119] Compared with Example 3, the difference lies in that the Gemini surfactant prepared in Preparation Example 3 is replaced by surfactant YH-103 (purchased from Zhengzhou Yihuo Fine Chemical Co., Ltd.).

[0120] Comparative Example 4

[0121] The difference from Example 3 is that the complex emulsifier is not added.

[0122] Raw material composition (parts by weight): odorless turpentine 30 parts, lemon essential oil 2.5 parts, deionized water 57 parts, 1,3-butanediol 3 parts, nano-antibacterial mite-killing and stain-removing particles prepared in Preparation Example 6 7 parts.

[0123] Comparative Example 5

[0124] The difference from Example 3 is that the odorless turpentine is not added.

[0125] Raw material composition (parts by weight): lemon essential oil 2.5 parts, complex emulsifier 7 parts, deionized water 80 parts, 1,3-butanediol 3 parts, nano-antibacterial mite-killing and stain-removing particles prepared in Preparation Example 6 7 parts.

[0126] Comparative Example 6

[0127] The difference from Example 3 is that the nano-antibacterial mite-killing and stain-removing particles are replaced by those prepared in Comparative Preparation Example 1.

[0128] Comparative Example 7

[0129] The difference from Example 3 is that the nano-antibacterial mite-killing and stain-removing particles are replaced by those prepared in Comparative Preparation Example 2.

[0130] Comparative Example 8

[0131] The difference from Example 3 is that the nano-antibacterial mite-killing and stain-removing particles are replaced by those prepared in Comparative Preparation Example 3.

[0132] Comparative Example 9

[0133] The difference from Example 3 is that the nano-antibacterial mite-killing and stain-removing particles are replaced by those prepared in Comparative Preparation Example 4.

[0134] Comparative Example 10

[0135] The difference from Example 3 is that the nano-antibacterial mite-killing and stain-removing particles are replaced by those prepared in Comparative Preparation Example 5.

[0136] Test Example 1: Antibacterial, mildew-proof, and mite-killing test

[0137] 1. The animal special detergent prepared by the examples 1-3 and the comparative examples 1-10 of the present application and the commercially available detergent are prepared into 1g / L sample liquid, a filter paper piece with a diameter of 5mm is put into the sample liquid, soaked for 10min, taken out, dried, and prepared for use. The prepared MRS liquid medium is poured into a conical flask, sterilized (0.1MPa, 121.5℃) for 20min, taken out and cooled, prepared into solid culture medium, coated with the experimental strain, put into the prepared filter paper piece, and cultured in a culture box at 37℃ for 12h, the size of the inhibition zone is observed, the diameter of the inhibition zone is measured by a vernier caliper, and recorded.

[0138] If the diameter of the inhibition zone is greater than 7mm, it is judged as having antibacterial effect; if the diameter of the inhibition zone is less than or equal to 7mm, it is judged as not having antibacterial effect. The antibacterial activity of the new antibacterial detergent is tested by the method of measuring the size of the inhibition zone.

[0139] The test strains are Escherichia coli ATCC25922 and Staphylococcus aureus ATCC25923, which are purchased from China Veterinary Drug Inspection Institute.

[0140] The results are shown in Table 1.

[0141]

[0142]

[0143] From the above table, it can be seen that the animal special detergent prepared by the examples 1-3 of the present application has good antibacterial performance.

[0144] 2. The mold prevention experiment is tested according to the test method of "Evaluation of the mold prevention performance of fabric products", the animal special detergent prepared by the examples 1-3 and the comparative examples 1-10 of the present application and the commercially available detergent are prepared into 1g / L sample liquid, and the test strains are Aspergillus (ATCC16404), Trichoderma viride (AS 3.2941), Penicillium funiculosum (GIM 3.103), and Chaetomium globasum (AS 3.3601).

[0145] The rating standard is: 0 level-no obvious mold growth under a magnifying glass; 1 level-sparse or local growth of mold, the coverage area on the sample surface is less than 10%; 2 level-the coverage area of mold on the sample surface is 10-30%; 3 level-the coverage area of mold on the sample surface is 30-60%; 4 level-the coverage area on the sample surface is more than 60%.

[0146] The results are shown in Table 2.

[0147] Table 2

[0148]

[0149] From the above table, it can be seen that the animal special detergents prepared by Examples 1-3 have good mildew resistance.

[0150] 3. Anti-mite test

[0151] The animal special detergents prepared by Examples 1-3 and Comparative Examples 1-10 and commercially available detergents were prepared into 10 g / L sample solutions. A piece of 10 mm x 200 mm sponge was placed in a covered container, the sample solution was injected, and the sponge was just covered, 200 live mites were placed in the container, the cover was placed on the container, and after 24 h, the survival of the mites was observed. The test was repeated three times, and the average value was calculated.

[0152] The results are shown in Table 3.

[0153] Table 3

[0154] Group Live mite number (only) Example 1 41 Example 2 40 Example 3 37 Comparative Example 1 46 Comparative Example 2 57 Comparative Example 3 55 Comparative Example 4 68 Comparative Example 5 50 Comparative Example 6 77 Comparative Example 7 82 Comparative Example 8 87 Comparative Example 9 99 Comparative Example 10 92 Commercially available 125

[0155] From the above table, it can be seen that the animal special detergents prepared by Examples 1-3 have good mite killing effect.

[0156] Appearance and stability test of test example 2

[0157] The animal special detergents prepared by Examples 1-3 were all clear and transparent, light yellow solutions, odorless, after being placed in an environment of-5℃ for 24 h, they were taken out and slowly restored to room temperature, no crystallization or precipitation was generated; they were placed in a constant temperature oven of (50±1)℃ for 24 h, and immediately observed after being taken out, no stratification and turbidity was generated, and the odor did not change, and the stability was qualified.

[0158] Irritation test of test example 3

[0159] According to the skin irritation / corrosion test of the “Cosmetic Safety Technology Specification” (2015 edition), the animal special detergents prepared by Examples 1-3 and Comparative Examples 1-10 and commercially available similar products were scored for skin reaction.

[0160] Select 56 healthy white rabbits, female, 1.9-2.3 kg, no skin damage, divided into 14 groups, 4 in each group. 24 hours before the test, the back of the experimental rabbit was shaved on both sides of the spine, without damaging the epidermis, and the hair was removed in an area of 3 cm x 3 cm on both sides. 0.5 mL of the test substance (i.e. the animal special detergent prepared in Examples 1-3 and Comparative Examples 1-10 and the same kind of product on the market) was directly applied to the skin, then covered with two layers of gauze (3 cm x 3 cm) and one layer of glass paper, and fixed with non-irritating adhesive tape and bandage. The other side of the skin was used as a control. A closed test was used, and the application lasted for 2 hours. After the test, the residual test substance was removed with warm water, and the skin reaction at the application site was observed at 1, 24, 48 and 72 hours after the test substance was removed. The skin reaction was scored according to Table 4, and the average value was taken. According to the highest integral average, the skin irritation intensity was determined according to Table 5.

[0161] Table 4

[0162] Skin reaction Score Erythema and eschar formation No erythema 0 Slight erythema (barely visible) 1 Obvious erythema 2 Moderate to severe erythema 3 Severe erythema (purplish red) to slight eschar formation 4 Edema formation No edema 0 Slight edema (barely visible) 1 Mild edema (clear outline of skin protuberance) 2 Moderate edema (1 mm skin protuberance) 3 Severe edema (more than 1 mm skin protuberance, spreading) 4 Maximum score 8

[0163] Table 5

[0164]

[0165]

[0166] The results are shown in Table 6.

[0167] Table 6

[0168] Group Total score mean Irritation intensity Example 1 0.12 No irritation Example 2 0.14 No irritation Example 3 0.10 No irritation Comparative Example 1 0.19 No irritation Comparative Example 2 0.42 No irritation Comparative Example 3 1.12 Mild irritation Comparative Example 4 0.78 Mild irritation Comparative Example 5 0.37 No irritation Comparative Example 6 0.62 Mild irritation Comparative Example 7 0.85 Mild irritation Comparative Example 8 0.91 Mild irritation Comparative Example 9 1.04 Mild irritation Comparative Example 10 0.72 Mild irritation Commercially available 2.45 Moderate irritation

[0169] From the above table, it can be seen that the animal special detergent prepared in Examples 1-3 of the present application has no skin irritation.

[0170] Test Example 4: Foamability and detergency test

[0171] The animal special detergents prepared in Examples 1-3 and Comparative Examples 1-10 of the present application and the same kind of product on the market were tested for foamability and detergency, and the results are shown in Table 7.

[0172] 1. Foamability test: Take 1 g of sample, add 49 g of deionized water, and after the sample is completely dissolved, slowly pour the aqueous solution into a foam bottle with a scale, and observe the foam height after shaking up and down 10 times

[0173] 2. Detergency test: Make standard soiled pieces from dirty and old clothes without washing, and add the prepared standard soiled pieces to the washing machine, and add an equal amount of animal special detergent for washing.

[0174] The decontamination effect evaluation method is as follows: 100 male and female volunteers are selected, the rinsed standard contaminated film is subjected to sensory evaluation, and the decontamination effect is evaluated by scoring according to the following 5 degrees: 80-100 points, very clean rinsing effect; 60-80 points, relatively clean rinsing effect; 40-60 points, general rinsing effect; 20-40 points, poor rinsing effect; and 0-20 points, no cleaning effect.

[0175] Table 7

[0176] Group Bubbling height (cm) Detergency score (points) Example 1 16.2 97 Example 2 16.5 98 Example 3 17.0 99 Comparative Example 1 14.1 89 Comparative Example 2 10.2 75 Comparative Example 3 11.4 80 Comparative Example 4 1.5 25 Comparative Example 5 13.9 87 Comparative Example 6 15.4 91 Comparative Example 7 15.3 95 Comparative Example 8 15.5 93 Comparative Example 9 15.1 92 Comparative Example 10 15.2 94 Commercially available 11.7 78

[0177] As shown in the above table, the animal special detergent prepared in Examples 1-3 has good foaming capacity and good decontamination effect.

[0178] Compared with Example 3, the complex emulsifier in Comparative Examples 1 and 2 is single sodium hexadecyl benzene sulfonate or Gemini surfactant. The foaming height and decontamination capacity decrease. The antibacterial, mildew-proof and acarid-removing effects in Comparative Example 2 also decrease to a certain extent, because the Gemini surfactant with quaternary ammonium salt structure has certain antibacterial, mildew-proof and acarid-removing effects. Compared with Example 3, no complex emulsifier is added in Comparative Example 4. The foaming height and decontamination capacity decrease obviously. In the animal special detergent of the present application, the complex emulsifier is added, which includes a mixture of anionic surfactant and Gemini surfactant. The Gemini surfactant refers to a surfactant with two hydrophilic groups and two hydrophobic groups, which is connected by a connecting group through a chemical bond at the hydrophilic group or near the hydrophilic group. The Gemini surfactant has strong aggregation capacity, surface activity and interfacial adsorption capacity, low critical micelle concentration and Krafft point, good solubilizing property, can be dissolved in cold water, has better calcium soap dispersing property and high-efficiency wetting property, has good synergistic effect with the anionic surfactant, the system has more excellent performance, has better hydrotropic property and biological safety, etc. At the same time, the sulfonic acid group, sulfuric acid group or benzene sulfonic acid group of the anionic surfactant combines with calcium, magnesium, iron and other ions in water to form a precipitate during rinsing, so that the content of the surfactant adsorbed on the animal fur surface is very low during rinsing, the surface charge of the animal fur is low, the friction between the animal furs is increased when the animal furs are in contact, and the rinsing property is improved.

[0179] Compared with Example 3, the Gemini surfactant prepared in Preparation Example 3 is replaced by surfactant YH-103 (purchased from Zhengzhou Yihe Fine Chemical Co., Ltd.). The foaming height and decontamination capacity decrease obviously, and the irritability increases.

[0180] Comparative Example 5, compared with Example 3, no odorless rosin is added. The decontamination ability is obviously decreased. The compound emulsifier of the present application also has a good compounding effect with solvent oil. Solvent oil has a good dissolving effect on some oil substances (substances secreted by sebaceous glands, which are generally developed in animals, and have a high content of oil substances) on animal hair, and under the emulsification of the compound emulsifier, the oil is removed from the fur, which has the effect of removing the odor of oil, cleaning the fur, and the like. In addition, the plant essential oil added at the same time has a good aromatic effect, which has a good effect of avoiding odor and has an antibacterial and acarid-killing effect.

[0181] Comparative Example 6, compared with Example 3, the nano antibacterial and acarid-killing decontamination particles are replaced by those prepared in Comparative Preparation Example 1. The antibacterial, mildew-proof and acarid-killing effects and the decontamination ability are decreased. The present application further prepares a nano antibacterial and acarid-killing decontamination particle. The nano hydroxyapatite prepared by a precipitation method is used as a carrier, and a polydopamine layer is coated on the surface, so that the surface contains a large number of hydroxyl groups, amino groups and carboxyl groups. The nano hydroxyapatite has a good hydrogen bond adsorption effect on berberine and baicalin. At the same time, the nano hydroxyapatite has a porous structure, which can promote the loading of the plant-derived antibacterial agent, so that the nano particle is loaded with a large amount of antibacterial agent. In addition, the polydopamine layer has a good hydrogen bond fixing effect on glucose, which promotes the in-situ reaction of the nano particle surface to generate nano silver. In addition, the amino structure on the polydopamine layer has a positive center, which also helps to adsorb the small dust particles (with a negative charge) on the fur, so that the prepared nano antibacterial and acarid-killing decontamination particle has excellent antibacterial, acarid-killing and decontamination effects.

[0182] Comparative Examples 7 and 8, compared with Example 3, the nano antibacterial and acarid-killing decontamination particles are replaced by those prepared in Comparative Preparation Examples 2 and 3. Comparative Example 9, compared with Example 3, the nano antibacterial and acarid-killing decontamination particles are replaced by those prepared in Comparative Preparation Example 4. The antibacterial, mildew-proof and acarid-killing effects are obviously decreased. In the present application, berberine and baicalin are natural plant-derived antibacterial agents, which are safe, non-toxic and have no side effects, and have a high-efficiency antibacterial and acarid-killing effect. Berberine has an antibacterial effect on hemolytic streptococcus, staphylococcus aureus, gonococcus and frisch and shiga dysentery bacillus, and has a white blood cell phagocytosis-enhancing effect, and has a different degree of inhibitory effect on tuberculosis bacillus and plague bacteria, and has an inhibitory effect on amoeba. Berberine has a broad-spectrum antibacterial effect. Baicalin has a wide antibacterial range and has a strong effect on staphylococcus aureus and green pyocyanin. Therefore, the combination of berberine and baicalin has a synergistic effect, and has a good inhibitory and expelling effect on animal fur mites.

[0183] Comparative Example 10, compared with Example 3, the nano antibacterial and acarid-killing decontamination particles are replaced by those prepared in Comparative Preparation Example 5, and the antibacterial, mildew-proof and acarid-killing effects are decreased. The nano silver generated in-situ on the surface of the present application will produce a small amount of Ag +The animal detergent prepared by the application has excellent antibacterial performance, is safe and non-toxic, and has good use safety and effectiveness.

[0184] The above merely describes preferred embodiments of the application, but should not be used to restrict the application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the application should be included in the protection scope of the application.

Claims

1. An animal-specific detergent, characterized by, Prepared from the following raw materials by weight parts: solvent oil 20-40 parts, plant essential oil 2-3 parts, composite emulsifier 5-10 parts, deionized water 20-80 parts, stabilizer 1-5 parts, nano antibacterial mite-killing and stain-removing particles 5-10 parts; The solvent oil is selected from at least one of petroleum solvent oil D60, odorless turpentine, petroleum ether; the stabilizer is selected from at least one of 1,3-butanediol, 1,2-propanediol, 1,6-cyclohexanediol; the plant essential oil is selected from at least one of tea tree essential oil, lemon essential oil, peppermint essential oil; The composite emulsifier comprises a mixture of sodium hexadecyl benzene sulfonate and Gemini surfactant, and the mass ratio is 2-3:7; the structural formula of the Gemini surfactant is shown as formula I: Formula I; wherein R = C m H 2m+1 ; n = 2-8; m = 12-18; The preparation method of the Gemini surfactant is as follows: T1. Dissolve 1 mole equivalent of polyethylene glycol and 3-5 mole equivalents of triethylamine in dichloromethane, add a solution of 2-2.1 mole equivalents of chloroacetyl chloride in dichloromethane, heat to 35-40°C, stir the reaction for 0.5-1 h, precipitate with saturated sodium bicarbonate solution, recrystallize from ethanol, filter, wash, and dry to produce an intermediate; the polyethylene glycol has the following structure: wherein n = 2-8; T2. Dissolve 1 mole equivalent of the intermediate and 3-5 mole equivalents of triethylamine in tetrahydrofuran, add 2-2.2 mole equivalents of N,N-dimethylalkylamine in tetrahydrofuran, heat to 50-60°C, stir for 1-2 h, remove the solvent under reduced pressure, extract with water and diethyl ether, dry the diethyl ether layer, filter, remove the diethyl ether under reduced pressure, wash, and dry to produce the Gemini surfactant; the N,N-dimethylalkylamine has the following structure: where R = C m H 2m+1 m = 12-18; The preparation method of the nano antibacterial mite-killing and stain-removing particles is as follows: S1. Preparation of nano hydroxyapatite: calcium salt is dissolved in water, acetic amide is added to prepare a mixed solution, phosphate is dissolved in water, the mixed solution is added dropwise, heated and stirred to react, aged, centrifuged, washed, dried to prepare nano hydroxyapatite; S2. Deposition of polydopamine: the nano hydroxyapatite prepared in step S1 is dispersed in water, dopamine hydrochloride and a catalyst are added, heated and stirred to react, centrifuged, washed, dried to prepare polydopamine modified hydroxyapatite; S3. Preparation of plant source antibacterial agent: berberine and baicalin are uniformly mixed to prepare a plant source antibacterial agent; S4. Preparation of nano particles loaded with antibacterial agent: the polydopamine modified hydroxyapatite prepared in step S2 is dispersed in water, the plant source antibacterial agent in step S3 is added, stirred to load, centrifuged, washed, dried to prepare nano particles loaded with antibacterial agent; S5. Deposition of nano silver: glucose is dissolved in water, the nano particles loaded with antibacterial agent prepared in step S4 are added, silver ammine complex ion solution is added dropwise, heated and stirred to react, centrifuged, washed, dried to prepare nano antibacterial mite-killing and stain-removing particles.

2. The detergent according to claim 1, characterized in that In step S1, the calcium salt is selected from at least one of calcium chloride and calcium nitrate, the phosphate is selected from at least one of sodium phosphate, potassium phosphate and ammonium phosphate, the mass ratio of the calcium salt, acetic amide and phosphate is 18-22:25-35:10-15, the heating and stirring reaction is carried out at a temperature of 60-80℃ for 1-3h, and the aging is carried out for 12-16h; in step S2, the mass ratio of the nano hydroxyapatite, dopamine hydrochloride and catalyst is 10:12-15:0.2-0.3, the catalyst is a Tris-HCl solution containing 2-3wt% CoCl2 with pH=5-6, the heating and stirring reaction is carried out at a temperature of 40-50℃ for 2-3h; in step S3, the mass ratio of berberine and baicalin is 3-5:

2.

3. The detergent of claim 1, wherein the detergent is a pet detergent. The mass ratio of the polydopamine modified hydroxyapatite and the plant source antibacterial agent in step S4 is 10:2-3, and the loading time of stirring is 20-30 min; the mass ratio of the glucose, the nanoparticle loaded with the antibacterial agent, and the silver ammine complex ion solution in step S5 is 3-5:10-12:7-10, the heating and stirring reaction temperature is 90-100℃, the time is 30-50 min, and the silver ammine complex ion solution is prepared by the following method: adding 22-25 wt% ammonia water into 0.5-1 mol / L silver nitrate solution drop by drop until the precipitate just disappears completely to obtain the silver ammine complex ion solution.

4. A process for the preparation of a detergent specially for animals as claimed in any one of claims 1 to 3, characterized in that, The method comprises the following steps: (1) heating solvent oil to 50-60℃, adding composite emulsifier, plant essential oil, stabilizer, and nano antibacterial and mite-killing and stain-removing particles, and stirring to mix uniformly; (2) adding deionized water while stirring, continuing to stir for 20-30 min, reducing to room temperature, discharging, and obtaining the animal special detergent.

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