A vascular thrombus removal system

Abstract

The present invention discloses a vascular thrombus removal system, which is composed of a removal system and an auxiliary system, wherein: the removal system is a hollow tube, the hollow tube is divided into a head section, a middle section and a tail section, and the diameter of the head section is larger than that of the tail section; the straight cutter and the oblique cutter are symmetrically arranged at the head section port, and the liquid port is symmetrically arranged, and the middle of the head section port is a suction tube cavity; a one-way blood flow filter is arranged at the junction of the middle section and the tail section, and the hollow tube of the middle section narrows at the one-way blood flow filter to the tail section; a straight knife propeller and an oblique knife propeller are arranged on the outer wall of the hollow tube from the narrowing to the tail section to control the rotation of the straight cutter and the oblique cutter; the auxiliary system includes a negative pressure aspirator, the negative pressure aspirator is connected to a thrombus collection box through a negative pressure tube, and there are also a sterile water tank, a liquid inlet tube, a water pump and a power supply. It has the advantages of multi-angle thrombus stripping, detachable thrombus blood, adaptability to complex blood vessel shapes, and can be used alone as a drug delivery sheath tube, convenient and flexible operation, minimally invasive treatment, and low cost.

Description

Technical Field

[0001] The present invention belongs to a medical auxiliary device, and specifically relates to a vascular thrombus removal system. The system has the functions of multi-angle thrombus stripping, thrombus blood separation, intravascular drug filling, vascular radiofrequency ablation and angiography, and is suitable for the treatment of venous thrombosis of different degrees. Background Art

[0002] Anticoagulation therapy is the main treatment for the vast majority of patients with venous thromboembolism, but its inherent limitations reduce the therapeutic effect. Anticoagulation therapy is the basic treatment for acute symptomatic VTE, and anticoagulation therapy should be started as soon as possible to prevent the spread of thrombus and promote vascular recanalization. However, the thrombus load improvement rate of simple anticoagulation therapy is low, the vascular recanalization rate is low, and the complete recanalization rate is even lower. If the thrombus is not completely removed in the acute phase, as the thrombus chronically organizes and intimalizes, not only the anticoagulant effect is weakened, but also the organized thrombus occupies the lumen, resulting in the loss of effective lumen, leading to cavernous degeneration of the main vein, venous stenosis, occlusion and venous hypertension. It can be seen that not only is the therapeutic window of the drug narrow, but the changes in patient response depend on a series of factors, including diet and concomitant drugs, so the individual differences in drug administration are large. In recent years, with the development of new thrombus removal equipment, thrombus removal devices have been widely used in the treatment of limb thrombosis because they can efficiently remove thrombus, reduce the dosage of thrombolytic drugs and the risk of bleeding. Device-assisted thrombus removal is fast, accurate in positioning, and has few side effects. There is no biochemical invasion of non-target areas by similar drugs. However, the human body's vascular network is well-developed, complex in structure, and tortuous in shape. Existing devices have more or less technical blind spots and cannot effectively complete the cleaning task. There is an urgent need for a vascular thrombus removal system that can efficiently complete thrombus removal.

[0003] It can be seen from this that the existing vascular thrombus removal systems are not satisfied with solving the current "medical, teaching, and research" problems in this field. It is necessary to design a removal device that can be suitable for patients with different degrees of thrombus and vascular inner diameters, thereby expanding the diagnosis rate of thromboembolic types. Summary of the invention

[0004] In order to overcome the defects or shortcomings in the above-mentioned prior art, the purpose of the present invention is to provide a vascular thrombus removal system.

[0005] In order to achieve the above tasks, the present invention adopts the following technical solutions:

[0006] A vascular thrombus removal system, characterized in that it consists of a removal system and an auxiliary system, wherein:

[0007] The cleaning system is a hollow tube, which is divided into a head section, a middle section and a tail section, and the diameter of the head section is larger than the diameter of the tail section;

[0008] A straight cutter and an oblique cutter are symmetrically arranged at the head section port, and liquid ports are symmetrically arranged on both sides of the straight cutter and the oblique cutter, and the middle of the head section port is a suction lumen;

[0009] A one-way blood flow filter is arranged at the junction of the middle section and the tail section, and the hollow tube of the middle section narrows at the one-way blood flow filter to the tail section; a straight knife propeller and an oblique knife propeller for controlling the rotation of the straight cutter and the oblique cutter are arranged on the outer wall of the hollow tube from the narrowing to the tail section;

[0010] The auxiliary system includes a negative pressure aspirator, which is connected to a thrombus collection box via a negative pressure tube, a sterile water tank, a water pump and a power supply, wherein a liquid inlet tube is provided on the water pump.

[0011] According to the present invention, the hollow tube is made of a biomaterial with toughness.

[0012] The vascular thrombus removal system of the present invention is suitable for the treatment of different degrees of venous thrombosis, and has the functions of multi-angle thrombus stripping, blood thrombus separation, intravascular drug filling, vascular radiofrequency ablation and angiography. It has the advantages of flexible and convenient operation, minimally invasive and efficient treatment, and low and reasonable cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 Schematic diagram of hemodynamics of normal blood vessels and thromboembolism, wherein (a) is a schematic diagram of normal blood vessels and stable hemodynamics, and (b) is a schematic diagram of thrombus blockage and disordered hemodynamics;

[0014] Figure 2 The figure is a schematic diagram of the appearance structure of the cleaning system; the upper left figure is the main view, the lower left figure is the top view, the upper right figure is the head section view (left view), and the lower right figure is the tail section view (right view);

[0015] Figure 3 It is a schematic diagram of the internal structure of the cleaning system;

[0016] Figure 4 It is a schematic diagram of the auxiliary system structure;

[0017] Figures 5 to 7 is a flow chart of multi-angle thrombus removal by a vascular thrombus removal system of an embodiment;

[0018] Figure 8 is a schematic diagram of a vascular thrombus removal system of an embodiment for separating thrombus from blood;

[0019] Fig. 9 is a schematic diagram of intravascular drug filling by a vascular thrombus removal system of an embodiment;

[0020] Fig.10 is a schematic diagram of a vascular thrombus removal system of an embodiment performing vascular radiofrequency ablation;

[0021] Fig.11 is a schematic diagram of angiography performed by the vascular thrombus removal system of the embodiment;

[0022] The marks in the figure represent respectively: 1. suction tube cavity, 2. straight knife propeller, 3. oblique knife propeller, 4. one-way blood flow filter, 5. straight cutter, 6. oblique cutter, 7. liquid port, 8. negative pressure aspirator, 9. negative pressure tube, 10. thrombus collection box, 11. sterile water tank, 12. water pump, 13. liquid inlet tube, 14. power supply, 15. thrombus collection tube, 16. medicine, 17. power pump, 18. medicine inlet tube, 19. medicine box, 20. radiofrequency ablation electrode, 21. cooling water tank, 22. water pipe, 23. radiofrequency transmitter, 24. water pipe and radiofrequency electrode insulated parallel pipeline, 25. contrast agent, 26. contrast channel, 27. contrast agent container.

[0023] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. DETAILED DESCRIPTION

[0024] This embodiment provides a vascular thrombus removal system, which is composed of a removal system and an auxiliary system, wherein:

[0025] The cleaning system is a hollow tube, which is divided into a head section, a middle section and a tail section, and the diameter of the head section is larger than that of the tail section; a straight cutter 5 and an oblique cutter 6 are symmetrically arranged at the port of the head section, and liquid outlets 7 are symmetrically arranged on both sides of the straight cutter 5 and the oblique cutter 6, and the middle of the head section port is an inhalation lumen 1; a one-way blood flow filter 4 is arranged at the junction of the middle section and the tail section, and the hollow tube of the middle section narrows at the one-way blood flow filter 4 to the tail section; a straight knife propeller 2 and an oblique knife propeller 3 are arranged on the outer wall of the hollow tube from the narrowing to the tail section to control the rotation of the straight cutter 5 and the oblique cutter 6; the cleaning system has the functions of multi-angle thrombus stripping, separation of thrombus blood, adaptation to complex blood vessel shapes, and can also be used alone as a drug delivery sheath;

[0026] The auxiliary system includes a negative pressure aspirator 8, a thrombus collection box 10, a sterile water tank 11, a water pump 12, a liquid inlet tube 13, a negative pressure tube 9, and a power supply 14, which are used to cooperate with the clearing system during the operation of clearing vascular thrombus.

[0027] The following is the specific implementation process of the vascular thrombus removal system.

[0028] 1. Normal blood vessels and thromboembolism

[0029] The vascular thrombus removal system of this embodiment is suitable for blood vessels with complex structures and tortuous shapes.

[0030] like Figure 1 (a) shows that there is no thrombus in the lumen of a normal blood vessel, the intima is smooth, and the hemodynamics is stable; Figure 1(b) The blood vessel blocked by thrombus has rough inner membrane, tortuous shape and disordered hemodynamics. Through the thrombus removal operation of the vascular thrombus removal system, the blood vessel is unblocked and the hemodynamics is stable.

[0031] (ii) Clearing system

[0032] Clear system appearance such as Figure 2 As shown, the structure of the removal system is a hollow tube made of tough biological material with a smooth outer surface. For ease of understanding, the hollow tube is divided into a head section, a middle section and a tail section; the diameter of the head section is larger than the diameter of the tail section, and a straight cutter 5, a liquid port 7 and an oblique cutter 6 are symmetrically distributed at the port of the head section; a one-way blood flow filter 4 is provided at the junction of the middle section and the tail section; the hollow tube narrows to the tail section at the one-way blood flow filter 4; on the outer wall of the hollow tube from the narrowing to the tail section, a straight knife propeller 2 and an oblique knife propeller 3 are provided to control the rotation of the straight cutter 5 and the oblique cutter 6. When in use, the head section of the hollow tube enters the blood vessel, and the one-way blood flow filter 4 is located in the blood vessel, and the straight knife propeller 2 and the oblique knife propeller 3 are outside the body, so that the doctor can adjust the size and angle of the straight cutter 5 and the oblique cutter 6.

[0033] In this embodiment, the suction lumen 1 of the front section of the hollow tube is used to collect larger thrombi, and is narrowed at the unidirectional blood flow filter 4 to filter the blood that enters the lumen of the hollow tube along with the thrombi, thereby minimizing the patient's blood loss during the operation and collecting thrombi to the greatest extent, reducing the movement of thrombi in the body and causing obstruction in other parts of the body.

[0034] Clear the system internal structure such as Figure 3 As shown, specifically including:

[0035] ① Head section: a straight cutter 5, a liquid port 7, and an oblique cutter 6 are provided. The three parts are symmetrically distributed at the upper and lower ends of the hollow tube, and the middle of the head section is the suction tube cavity 1;

[0036] ② Middle section: A one-way blood flow filter 4 is arranged at the junction of the lumen of the hollow tube in the middle section and the lumen of the tail section, so that the hollow tube becomes narrower at the one-way blood flow filter 4, and the remaining external space allows the filtered blood to flow away;

[0037] ③ Tail section: a straight knife pusher 2 and an oblique knife pusher 3 are provided, which are located outside the patient's body during the operation and can adjust the angle and size of the straight cutter 5 and the oblique cutter 6 according to the shape of the thrombus in the blood vessel.

[0038] (III) Auxiliary system

[0039] like Figure 4As shown, the auxiliary system includes a negative pressure aspirator 8, which is connected to a thrombus collection box 10 through a negative pressure tube 9, a sterile water tank 11, a water pump 12, a liquid inlet tube 13 on the water pump 12, and a power supply 14. Among them, the thrombus collection box 10 is connected to the hollow lumen of the tail section of the removal system, and the thrombus after stripping is recovered by the negative pressure aspirator 8. The sterile water tank 11 is powered by the water pump 12, and sterile saline is pumped into the removal system of the vascular thrombus removal device through the liquid inlet tube 13, and then flows out from the liquid outlet 7 of the front section of the hollow tube to flush the vascular lumen and thrombus, which is convenient for negative pressure recovery. The power supply 14 provides power for the water pump 12 and the negative pressure aspirator 8. According to the actual application, the auxiliary system can also use a power pump, a drug box, a cooling water tank, a radio frequency transmitter, a contrast agent container, etc.

[0040] (IV) Specific applications of vascular thrombus removal system

[0041] The vascular thrombus removal system provided in this embodiment is an auxiliary device for surgical operations. Before the operation, it is necessary to strictly follow the surgical procedure. Before using the vascular thrombus removal system, check whether the vascular thrombus removal is complete as a whole, whether the connections between the various connection ports are tight and fixed, and then determine the degree of thrombus blockage under visual means such as ultrasound or MRI, and select the puncture point and entry depth of the vascular thrombus. And use a marking pen to draw the approximate location of the thrombus on the patient's skin to avoid misoperation. Adjust the posture according to the patient's body shape and thrombus location, and the patient can lie or sit. According to the distribution of thrombi in the blood vessels and the size of the inner diameter of the blood vessels, adjust the angle and size of the straight and oblique blade propellers, perform thrombus removal operations against the direction of blood flow, and adopt an operation mode of cleaning thrombi while flushing with sterile water and recovering under negative pressure. If the patient has vascular endothelial damage, the drug can also be injected through the liquid inlet of the device, and the straight and oblique blade propellers are adjusted to evenly apply the drug to the vascular endothelial damage, while paying attention to the patient's blood loss. After the operation is completed, the device is pulled out to suture, disinfect and bandage the wound, and the used cleaning system is recycled according to the medical waste disposal method to prevent medical waste pollution.

[0042] 1. Multi-angle thrombus removal:

[0043] See also Figures 5 to 7 , Figures 5 to 7 A flow chart of multi-angle thrombus removal by the vascular thrombus removal system is provided. The negative pressure aspirator 8 of the auxiliary system is connected to the thrombus collection box 10 via the negative pressure tube 9. The sterile water tank 11 is connected to the water pump 12 via the liquid inlet tube 13 and enters the liquid port 7. The tail section is connected to the thrombus collection box 10 via the thrombus collection tube 15.

[0044] The location of thrombus in the blood vessel is randomly attached, and the degree of blockage varies. Under the display of ultrasound or MRI, the vascular thrombus removal system removes the thrombus one by one. The removal system goes against the blood flow, and under the joint action of blood flow and negative pressure suction device 8, the thrombus is efficiently recovered. The straight knife pusher 2 and the oblique knife pusher 3 of the straight cutter 5 and the oblique knife 6 can adjust the size and working angle of the two cutters. The operation is simple and flexible, and the thrombus is finally collected in the thrombus collection box 10.

[0045] 2. Thrombosis blood separation:

[0046] See also Figure 8 , Figure 8 A schematic diagram of thrombus blood separation in a vascular thrombus removal system is provided; the negative pressure aspirator 8 of the auxiliary system is connected to the thrombus collection box 10 via the negative pressure tube 9, the sterile water tank 11 is connected to the water pump 12 via the liquid inlet tube 13 and then enters the liquid port 7, and the tail section is connected to the thrombus collection box 10 via the thrombus collection tube 15.

[0047] When performing thrombus stripping, the removal system moves against the direction of blood flow, and can collect thrombi with the help of blood flow and negative pressure suction. When thrombi enter the middle section of the removal system, the lumen becomes narrow, and the excess blood is filtered through the one-way blood flow filter 4, reducing the patient's blood loss and increasing the efficiency of thrombus collection. The thrombi are finally collected in the thrombus collection box 10.

[0048] 3. Intravascular drug filling:

[0049] See also Fig. 9 , Fig. 9 A schematic diagram of intravascular drug filling in a vascular thrombus removal system is provided; a drug box 19 filled with drug 16 enters the liquid port 7 through a power pump 17 and a drug inlet pipe 18 .

[0050] Inflammation of the endothelium and external force damage are serious injuries to blood vessels. There are risks of hemangioma, dissection and rupture in the main blood vessels. Filling the endothelium with drugs through a vascular thrombus removal system is a safe and effective way to repair. When the drug 16 is injected, the movement of the removal system is in the same direction as the blood flow, reducing the damage of the blood flow to the stable attachment of the drug.

[0051] 4. Vascular radiofrequency ablation and angiography:

[0052] See also Fig.10 , Fig.10 A schematic diagram of a vascular thrombus removal system for performing vascular radiofrequency ablation is given; a radiofrequency transmitter 23 is connected to a power source 14, a cooling water tank 21 and a power pump 17 are connected via a water pipe 22, and a parallel pipeline 24 insulated from the radiofrequency electrode via a water pipe is connected to a liquid port 7, and a radiofrequency ablation electrode 20 is placed at the closed blood vessel end.

[0053] Venous thrombosis blocks blood vessels for a long time, causing venous tortuosity. The most typical case is superficial varicose veins in the lower limbs. In severe cases, it can cause skin rot in the varicose veins. At present, an effective treatment method is to perform radiofrequency ablation on varicose veins under ultrasound guidance to close the blood vessels. In the later recovery stage, the blood is diverted to the deep veins. During the ablation process, the removal system moves along the blood flow, and cooling water and radiofrequency ablation are carried out simultaneously to avoid high temperature burns to tissues outside the target blood vessels. The radiofrequency ablation electrode is made of soft material and its diameter matches the same liquid port 7. The inside is insulated and parallel by the radiofrequency ablation electrode and the cooling water pipe to cool the non-heating part. Only the tip of the radiofrequency ablation electrode needs to be heated. After radiofrequency ablation of the target blood vessels, the blood vessels are deformed and closed by heat, achieving the clinical treatment purpose.

[0054] See also Fig.11 , Fig.11 A schematic diagram of angiography using a vascular thrombus removal system is provided; a contrast agent container 27 is connected to the liquid port 7 through a contrast channel 26 and a power pump 17. Contrast agent is injected under ultrasound to evaluate the degree of vascular closure. In clinical treatment, contrast agent can be injected simultaneously during radiofrequency ablation to achieve a real-time evaluation effect.

[0055] (V) System maintenance

[0056] The vascular thrombus removal system provided in this embodiment is a medical device and needs to be strictly sterile and sealed and placed in a cool, dry and ventilated place. Before use, the skin near the target area of ​​thrombus should be disinfected and draped in strict accordance with the surgical regulations. After the operation, medical devices and waste materials should be recycled in accordance with the hospital's infection control regulations. After the operation, turn off the power and put the items away.

Claims

1. A vascular thrombus removal system, characterized in that: It consists of a cleaning system and an auxiliary system, including: The cleaning system is a hollow tube, which is divided into a head section, a middle section and a tail section, and the diameter of the head section is larger than the diameter of the tail section; A straight cutter and an oblique cutter are symmetrically arranged at the head section port, and liquid ports are symmetrically arranged on both sides of the straight cutter and the oblique cutter, and the middle of the head section port is a suction lumen; A one-way blood flow filter is arranged at the junction of the middle section and the tail section, and the hollow tube of the middle section narrows at the one-way blood flow filter to the tail section; a straight knife propeller and an oblique knife propeller for controlling the rotation of the straight cutter and the oblique cutter are arranged on the outer wall of the hollow tube from the narrowing to the tail section; The auxiliary system includes a negative pressure aspirator, which is connected to a thrombus collection box via a negative pressure tube, a sterile water tank, a water pump and a power supply, wherein a liquid inlet tube is provided on the water pump.

2. The vascular thrombus removal system according to claim 1, characterized in that: The hollow tube is made of a biomaterial with toughness.

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