Micro-needle coating and filling system

Abstract

The present application provides a kind of microneedle glue filling system, it includes: negative pressure chamber, leakage plate assembly and rotary glue coating component;The negative pressure chamber is used to accommodate and carry microneedle mold, and is used to be connected with negative pressure end to form negative pressure;The leakage plate assembly is arranged in the negative pressure chamber;The leakage plate assembly includes leakage plate and accommodating cavity;The accommodating cavity is opened along the direction of first axis, and the leakage plate is arranged in one end of the accommodating cavity along the direction of first axis;The leakage plate has the shape and position matched with the through hole of microneedle mold, and the through hole is communicated with the accommodating cavity;The rotary glue coating component is rotatably penetrated into the accommodating cavity with the first axis as the rotation shaft and abuts against the leakage plate;The rotary glue coating component is used to glue under the action of negative pressure of the negative pressure chamber, and the glued glue is scraped to the surface of the microneedle mold through the through hole by rotating around the first axis.The consistency of glue coating thickness and plane size can be effectively controlled.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a microneedle gluing and filling system. BACKGROUND

[0002] Micro-molding is a high-precision micro-nano manufacturing technology for forming microstructures by means of micro-replication molds. This technology has the advantages of high replication precision, low cost, and small residual stress, and is widely used in the preparation of micro-nano structures such as micro-gears, microneedles, micro-fluidic chips, and light guide plates in various fields such as machinery, medicine, and biology.

[0003] In the prior art, after solid microneedles are manufactured in several separate and unconnected cavities of a microneedle mold by means of pressure filling, centrifugal filling, or vacuum filling, it is difficult to individually demold the solid microneedles. Therefore, a method of gluing the surfaces of the cavities is adopted to connect the solid microneedles together. After the glue solidifies, the solid microneedles can be easily demolded.

[0004] However, the current gluing technology is relatively wasteful of glue, and the glue is not easy to recover. The consistency of the gluing thickness and planar size fluctuates greatly, which can cause high glue costs and unstable product quality. In addition, the existing gluing equipment is large in size and has low space utilization. SUMMARY

[0005] The present application aims to provide a microneedle gluing and filling system to solve the problems of waste of glue and unstable gluing quality of the existing gluing device.

[0006] To solve the above technical problems, the present application provides a microneedle gluing and filling system, which comprises a negative pressure chamber, a leakage plate assembly, and a rotary gluing assembly.

[0007] The negative pressure chamber is used to accommodate and carry the microneedle mold and is connected with a negative pressure end to form a negative pressure.

[0008] The leakage plate assembly is arranged in the negative pressure chamber. The leakage plate assembly comprises a leakage plate and an accommodation cavity. The accommodation cavity is opened along the direction of a first axis, and the leakage plate is arranged at one end of the accommodation cavity along the direction of the first axis. The leakage plate has through holes matched with the shape and position of the microneedle mold, and the through holes are in communication with the accommodation cavity.

[0009] The rotary gluing assembly is rotatably penetrated into the accommodation cavity along the first axis and abuts against the leakage plate. The rotary gluing assembly is used to glue under the action of the negative pressure of the negative pressure chamber and scrape the glued glue through the through holes to the surface of the microneedle mold by rotating around the first axis.

[0010] Optionally, the negative pressure chamber comprises a housing and a base, the base is configured to carry the microneedle mold, the housing is configured to move relative to the base along the first axis to abut against or separate from the base; when the housing abuts against the base, a closed cavity is formed and covers the microneedle mold.

[0011] Optionally, the weep plate assembly is movably arranged in the housing along the first axis; when the housing moves towards the base, the weep plate assembly abuts against the base no later than the housing.

[0012] Optionally, the microneedle glue filling system comprises a first potential energy component, the weep plate assembly is connected with the housing through the first potential energy component; when the housing moves towards the base and the weep plate assembly does not abut against the base, the weep plate assembly moves with the housing; after the weep plate assembly abuts against the base, the housing continues to move towards the base to store energy in the first potential energy component, and the first potential energy component applies a potential force to the weep plate assembly towards the base.

[0013] Optionally, the rotary glue coating assembly comprises a glue coating head and a support, the support is rotatably arranged in the housing with the first axis as the rotation axis, and the support rotates around the first axis to drive the glue coating head to abut against the weep plate.

[0014] The microneedle glue filling system comprises a second potential energy component, the glue coating head is movably connected with the support along the direction of the first axis through the second potential energy component; after the weep plate assembly abuts against the base, the housing continues to move towards the base to store energy in the second potential energy component, and the second potential energy component applies a potential force to the glue coating head towards the weep plate.

[0015] Optionally, the base comprises a height adjustment plate, the height adjustment plate is configured to abut against the lower surface of the weep plate, the height adjustment plate and / or the weep plate are replaceable, and the thickness of the height adjustment plate and / or the weep plate along the direction of the first axis is used to adapt to adjust the vertical distance between the upper surface of the weep plate and the upper surface of the microneedle mold.

[0016] Optionally, the microneedle glue filling system comprises a glue amount adjusting assembly; the glue amount adjusting assembly is configured to periodically change the glue coating amount of the rotary glue coating assembly as the rotary glue coating assembly rotates around the first axis.

[0017] Optionally, the negative pressure chamber comprises a housing, and the rotary glue coating assembly comprises a glue coating head and a support; the support is rotatably arranged through the housing with the first axis as the rotation axis.

[0018] The glue amount adjusting assembly comprises a flexible connecting pipe, a limiting piece and a clamping piece.

[0019] The flexible connecting pipe is connected with the glue applying head and the support respectively; the limiting piece is arranged on the shell, and the clamping piece is movably arranged on the support in a direction at an angle to the first axis and rotates with the support to periodically abut against or separate from the limiting piece;

[0020] When the clamping piece abuts against the limiting piece, the clamping piece extrudes the flexible connecting pipe to reduce the flow area of the flexible connecting pipe;

[0021] When the clamping piece separates from the limiting piece, the clamping piece releases the extrusion on the flexible connecting pipe.

[0022] Optionally, the glue amount adjusting assembly comprises a third potential energy component, the clamping piece is connected with the support through the third potential energy component; when the clamping piece rotates with the support from abutting against the limiting piece to separating from the limiting piece, the third potential energy component stores energy; when the clamping piece rotates with the support from abutting against the limiting piece to separating from the limiting piece, the third potential energy component releases energy to drive the clamping piece to move away from the first axis to release the extrusion on the flexible connecting pipe.

[0023] Optionally, the clamping piece has a pulley at one end for abutting against the limiting piece, and the clamping piece abuts against the limiting piece through the pulley.

[0024] Optionally, the rotating glue applying assembly comprises a glue applying head, the glue outlet of the glue applying head is in a strip shape extending in a direction perpendicular to the first axis; and / or, the outer contour of the part of the glue applying head penetrating into the accommodating cavity is in a strip shape extending in a direction perpendicular to the first axis.

[0025] Optionally, the extension length of the strip shape of the glue applying head or the glue outlet is matched with the inner diameter of the accommodating cavity.

[0026] Optionally, the microneedle glue applying and filling system further comprises a driving assembly for driving the rotating glue applying assembly to rotate around the first axis; wherein the driving assembly is arranged outside the negative pressure chamber.

[0027] In summary, the microneedle glue filling system provided by the application comprises a negative pressure chamber, a sieve plate assembly and a rotary glue coating assembly; the negative pressure chamber is used for accommodating and carrying a microneedle mold and is connected with a negative pressure end to form a negative pressure; the sieve plate assembly is arranged in the negative pressure chamber; the sieve plate assembly comprises a sieve plate and an accommodation cavity; the accommodation cavity is opened along the direction of a first axis, and the sieve plate is arranged at one end of the accommodation cavity along the direction of the first axis; the sieve plate has a through hole matched with the shape and position of the microneedle mold, and the through hole is communicated with the accommodation cavity; the rotary glue coating assembly is rotatably penetrated into the accommodation cavity along the first axis and abuts against the sieve plate; the rotary glue coating assembly is used for coating glue under the action of the negative pressure of the negative pressure chamber and scraping the coated glue to the surface of the microneedle mold through the through hole by rotating around the first axis.

[0028] In this way, on the one hand, the rotary glue coating assembly scrapes the coated glue to the surface of the microneedle mold through the through hole by rotating around the first axis, so that the consistency of the glue coating thickness and the plane size of the surface of the microneedle mold can be effectively controlled; meanwhile, since the glue is coated by rotating, the excess glue can be reserved in the accommodation cavity and reused when the next microneedle mold is coated, so that the waste of glue is effectively reduced. On the other hand, the rotary glue coating assembly coats glue based on the negative pressure, so that the amount of coated glue is controllable and the consistency of the product is good. BRIEF DESCRIPTION OF DRAWINGS

[0029] Those skilled in the art will understand that the provided drawings are for the purpose of better illustrating the present application and do not constitute any limitation on the scope of the present application. Among them:

[0030] Figure 1 is a schematic diagram of the microneedle glue filling system of an embodiment of the application;

[0031] Figure 2 is a schematic diagram of the microneedle glue filling system of an embodiment of the application;

[0032] Figure 3 is a partial schematic diagram of the microneedle glue filling system of an embodiment of the application;

[0033] Figure 4a is a schematic diagram of the rotary glue coating assembly, the sieve plate assembly and the microneedle mold of an embodiment of the application;

[0034] Figure 4b is a schematic diagram of the height adjustment plate, the sieve plate assembly and the microneedle mold of another embodiment of the application;

[0035] Figure 5 is an axial cross-sectional schematic diagram of the microneedle glue filling system of an embodiment of the application;

[0036] Figure 6 is Figure 5 a B part enlarged view of

[0037] Figure 7 is a top view of the glue amount adjusting assembly of an embodiment of the present application, wherein the glue amount adjusting assembly is in a closed state;

[0038] Figure 8 is a top view of the glue amount adjusting assembly of an embodiment of the present application, wherein the glue amount adjusting assembly is in an open state;

[0039] Figure 9 is a schematic view of the glue amount adjusting assembly of another embodiment of the present application.

[0040] In the drawings:

[0041] 100 - negative pressure chamber; 110 - shell; 120 - base; 121 - height adjustment plate; 200 - grid assembly; 210 - grid; 211 - through hole; 220 - accommodating cavity; 230 - connecting seat; 240 - guide column; 241 - abutting portion; 300 - rotary glue applying assembly; 310 - glue applying head; 320 - support; 321 - clamping element through hole; 322 - guide pin; 410 - first potential energy component; 411 - first spring; 420 - second potential energy component; 421 - second spring; 430 - third potential energy component; 431 - third spring; 500 - glue amount adjusting assembly; 510 - flexible connecting pipe; 520 - limiting element; 530 - clamping jaw; 531 - guide groove; 532 - pulley; 540 - clamping jaw; 600 - driving assembly; 610 - torque motor; 620 - first gear; 630 - second gear; 700 - lifting assembly; 710 - air cylinder; 721 - linear bearing; 722 - lifting column; 810 - negative pressure end; 811 - first vacuum valve; 812 - second vacuum valve; 813 - third vacuum valve; 814 - fourth vacuum valve; 815 - vacuum pump; 816 - vacuum gauge; 820 - glue supply end; 821 - glue storage barrel; 900 - microneedle mold. DETAILED DESCRIPTION

[0042] In order to make the purpose, advantages and features of the present application clearer, the following further details the present application in combination with the drawings and specific embodiments. It should be noted that the drawings are all very simplified and not drawn to scale, and are only used to facilitate and clarify the purpose of assisting the description of the embodiments of the present application. In addition, the structures shown in the drawings are often part of the actual structure. In particular, the emphasis shown in each drawing is different, and sometimes different scales are used.

[0043] As used in the present application, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. The term "or" is generally employed in its sense of "and / or" unless the context clearly dictates otherwise. The term "plurality" is generally employed in its sense of "two or more" unless the context clearly dictates otherwise. The terms "first," "second," "third," etc. are used only to describe a particular object and do not imply or suggest relative importance or an implied indication of the number of the technical features indicated. Thus, features defined with "first," "second," "third" can explicitly or implicitly include one or at least two of the features. "One end" and "the other end" and "proximal end" and "distal end" generally refer to two parts corresponding to each other, which not only includes the end points. In addition, as used in the present application, "mounting", "connecting", "connecting", "setting" one element in another element should be broadly understood, and generally only indicates that there is a connection, coupling, cooperation or transmission relationship between the two elements, and the two elements can be directly or indirectly connected, coupled, cooperated or transmitted through intermediate elements, and cannot be understood as indicating or suggesting the spatial positional relationship between the two elements, that is, one element can be in any orientation inside, outside, above, below or one side of another element, unless the content is otherwise clearly indicated. For those of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances. In addition, directional terms such as above, below, up, down, upward, downward, left, right, etc. are used with respect to the exemplary embodiments as they are shown in the drawings, upward or upward direction is towards the top of the corresponding drawing, and downward or downward direction is towards the bottom of the corresponding drawing.

[0044] The purpose of the present application is to provide a microneedle glue coating and filling system to solve the problem of waste glue and unstable glue coating quality of the existing glue coating device. The following description is made with reference to the accompanying drawings.

[0045] Please refer to Figures 1 to 9The embodiment of the present application provides a microneedle glue filling system, which comprises a negative pressure chamber 100, a runner assembly 200 and a rotary glue coating assembly 300; the negative pressure chamber 100 is used for accommodating and carrying a microneedle mold 900 and is used for being connected with a negative pressure end 810 to form a negative pressure; the runner assembly 200 is arranged in the negative pressure chamber 100; the runner assembly 200 comprises a runner 210 and an accommodating cavity 220; the accommodating cavity 220 is opened along the direction of a first axis A1, and the runner 210 is arranged at one end of the accommodating cavity 220 along the direction of the first axis A1; the runner 210 has a through hole 211 matched with the shape and position of the microneedle mold 900, and the through hole 211 is communicated with the accommodating cavity 220; the rotary glue coating assembly 300 is rotatably penetrated into the accommodating cavity 220 along the first axis A1 and abuts against the runner 210; the rotary glue coating assembly 300 is used for coating glue under the action of the negative pressure of the negative pressure chamber 100 and scraping the coated glue to the surface of the microneedle mold 900 through rotation around the first axis A1.

[0046] The inside of the negative pressure chamber 100 has a cavity connected with the negative pressure end 810, which can provide a negative pressure environment required for production. Figure 1 The lower half of the rotary glue coating assembly 300 is arranged in the negative pressure chamber 100, and the upper half of the rotary glue coating assembly 300 is penetrated out of the negative pressure chamber 100 and connected with a glue supply end 820. Figure 1 It can be understood that the rotary glue coating assembly 300 has a flow channel for the flow of glue. The glue supply end 820 is, for example, a glue storage barrel 821, so that the pressure difference between the cavity in the inside of the negative pressure chamber 100 and the glue supply end 820 can make the glue be sucked into the negative pressure chamber 100 from the glue supply end 820 through the flow channel of the rotary glue coating assembly 300 and be discharged from the outlet of the flow channel of the rotary glue coating assembly 300 (hereinafter referred to as a glue outlet). It can be understood that by adjusting the pressure difference between the cavity in the inside of the negative pressure chamber 100 and the glue supply end 820, the flow rate of the glue can be adjusted, and then the amount of glue coating can be adjusted. Further, the rotary glue coating assembly 300 rotates around the first axis A1, so that the glue can be scraped to the surface of the microneedle mold 900 through the through hole 211.

[0047] In this way, on the one hand, the rotary glue coating assembly 300 rotates around the first axis A1 to scrape the coated glue to the surface of the microneedle mold 900 through the through hole 211, which can effectively control the consistency of the glue coating thickness and the planar size of the surface of the microneedle mold 900, and at the same time, since the glue is coated by rotation, the excess glue can be reserved in the accommodating cavity 220 and reused when the next microneedle mold 900 is coated, which effectively reduces the waste of glue. On the other hand, the rotary glue coating assembly 300 is based on negative pressure coating, and the amount of glue coating is controllable, so that the product consistency is good.

[0048] InFigure 1 In the example shown, the negative pressure end 810 includes, for example, a vacuum pump 815, a first vacuum valve 811, a second vacuum valve 812, a third vacuum valve 813, and a fourth vacuum valve 814. One end of the first vacuum valve 811 is connected to the vacuum pump 815, and the other end is connected to the negative pressure chamber 100 and the second vacuum valve 812. One end of the second vacuum valve 812 is connected to the negative pressure chamber 100 and the first vacuum valve 811, and the other end is connected to the third vacuum valve 813 and the glue storage barrel 821. One end of the third vacuum valve 813 is connected to the glue storage barrel 821 and the second vacuum valve 812, and the other end is connected to the atmosphere. One end of the fourth vacuum valve 814 is connected to the negative pressure chamber 100, and the other end is connected to the atmosphere. Optionally, a vacuum gauge 816 can be provided to monitor the air pressure in the negative pressure chamber 100.

[0049] When glue needs to be applied by the spin coating assembly 300, the vacuum pump 815 is turned on, the first vacuum valve 811 and the second vacuum valve 812 are opened, and the third vacuum valve 813 and the fourth vacuum valve 814 are closed to pump the cavities in the glue storage barrel 821 and the negative pressure chamber 100. When the specified vacuum degree is reached, the first vacuum valve 811 and the second vacuum valve 812 are closed, the vacuum pump 815 is turned off, and the third vacuum valve 813 is opened to form a pressure difference between the air pressure above the glue in the glue storage barrel 821 and the negative pressure chamber 100. When the pressure difference reaches the requirement, the third vacuum valve 813 is closed again. This pressure difference allows the glue in the glue storage barrel 821 to be sucked into the negative pressure chamber 100 through the spin coating assembly 300. The size of the pressure difference can control the flow rate of the glue flowing out of the spin coating assembly 300, thereby adjusting the amount of glue applied. After the glue application is completed, the third vacuum valve 813 and the fourth vacuum valve 814 are both opened to break the vacuum in the glue storage barrel 821 and the negative pressure chamber 100, i.e., to restore the initial state.

[0050] Of course, the above example is only one example of the negative pressure end 810 and is not a limitation on the negative pressure end 810. In other embodiments, the negative pressure end 810 can also use the centralized negative pressure pipeline of the production workshop, and the present embodiment is not limited thereto.

[0051] Please refer to Figure 1 , Figure 2 and Figure 3, preferably, the negative pressure chamber 100 comprises a housing 110 and a base 120, the base 120 is used to carry the microneedle mold 900, the housing 110 is used to move along the first axis A1 relative to the base 120 to abut or separate from the base 120; when the housing 110 abuts the base 120, a closed cavity is formed and covers the microneedle mold 900. In order to facilitate the microneedle mold 900 to be put into the negative pressure chamber 100 and taken out of the negative pressure chamber 100, the negative pressure chamber 100 is preferably configured as an openable and closable structure. In a preferred example, when the housing 110 abuts the base 120, the inside can form a closed cavity that covers the microneedle mold 900, it can be understood that at this time, if the cavity inside the negative pressure chamber 100 is pumped by the vacuum pump 815, the cavity inside the negative pressure chamber 100 can form a negative pressure. After the glue coating of the microneedle mold 900 is completed, the housing 110 moves upward away from the base 120, then the glued microneedle mold 900 can be taken out, and the next microneedle mold 900 to be coated can be replaced.

[0052] Please refer to Figure 4a In an alternative example, the leakage plate assembly 200 comprises a connecting seat 230, the connecting seat 230 is a plate-shaped member extending in a direction perpendicular to the first axis A1, and the accommodating cavity 220 is provided through the connecting seat 230. In Figure 2 the example shown, the accommodating cavity 220 is cylindrical. The leakage plate 210 is connected to one end of the accommodating cavity 220. The position and shape of the through hole 211 provided on the leakage plate 210 are matched with the position and shape of the microneedle mold 900. In Figure 2 the example shown, corresponding to two circular microneedle molds 900 arranged side by side in a direction perpendicular to the first axis A1, two circular through holes 211 are provided on the leakage plate 210.

[0053] Further, the rotary glue coating assembly 300 comprises a glue coating head 310, and the glue outlet of the rotary glue coating assembly 300 is provided on the glue coating head 310, which is preferably in the shape of a strip extending in a direction perpendicular to the first axis A1. At least a part of the glue coating head 310 can extend into the accommodating cavity 220 and abut against the leakage plate 210, and the outer contour of the part of the glue coating head 310 extending into the accommodating cavity 220 is preferably in the shape of a straight strip extending in a direction perpendicular to the first axis A1. More preferably, the extension length of the strip-shaped glue coating head 310 or glue outlet is matched with the inner diameter of the accommodating cavity 220, such as slightly smaller than the inner diameter of the accommodating cavity 220. In this way, the glue coating head 310 divides the accommodating cavity 220 into two semicircular parts, and when the glue coating head 310 rotates, the glue moves back and forth in the closed space of the two semicircular parts due to the limiting action of the cavity wall of the accommodating cavity 220 and the leakage plate 210, so that the glue scraping is more uniform, further improves the utilization rate of the glue, and prevents the excess glue from remaining in positions other than the working area of the glue coating head 310.

[0054] When the glue needs to be applied to the microneedle mold 900, the drip plate assembly 200 is located close to the microneedle mold 900, the through hole 211 is aligned with the microneedle mold 900, but the upper surface of the microneedle mold 900 (i.e. the side surface facing the glue head 310) does not exceed the upper surface of the drip plate 210 (i.e. the side surface abutting against the glue head 310). The vertical distance between the upper surface of the drip plate 210 and the upper surface of the microneedle mold 900 is the glue thickness. At this time, the glue head 310 rotates around the first axis A1, and the glue is scraped through the through hole 211 to the upper surface of the microneedle mold 900. At the same time, the excess glue is retained in the accommodating cavity 220 with the rotation of the glue head 310, which can be reused for the next microneedle mold 900, effectively reducing the waste of glue.

[0055] Optionally, the base 120 comprises a height adjustment plate 121 for abutting against the lower surface of the drip plate 210 to prevent glue from leaking out. As shown in Figure 3 and Figure 4a In some embodiments, the drip plate 210 is detachable or replaceable. As can be easily understood, since the glue head 310 abuts against the upper surface of the drip plate 210 and the height adjustment plate 121 abuts against the lower surface of the drip plate 210, the glue thickness can be adjusted by adjusting the thickness of the drip plate 210.

[0056] As shown in Figure 3 and Figure 4b In other embodiments, the height adjustment plate 121 is detachable or replaceable, and the thickness of the height adjustment plate 121 matches the thickness of the microneedle mold 900, i.e. the upper surface of the microneedle mold 900 is flush with the upper surface of the height adjustment plate 121, and both abut against the lower surface of the drip plate 210. At this time, the glue thickness can be adjusted by adjusting the thickness of the height adjustment plate 121 and the microneedle mold 900. Optionally, the microneedle mold 900 itself can also have a recess aligned with the through hole 211 and a protrusion for abutting against the lower surface of the drip plate 210, and the thickness of the height adjustment plate 121 is the same as the thickness of the protrusion. Thus, the thickness of the height adjustment plate 121 and / or the drip plate 210 in the direction of the first axis A1 is used to adapt to adjust the vertical distance between the upper surface of the drip plate 210 and the upper surface of the microneedle mold 900, i.e. in use, the height adjustment plate 121 and / or the drip plate 210 can be disassembled and replaced according to the required glue thickness, and the appropriate thickness of the height adjustment plate 121 and / or the drip plate 210 is selected to adjust the vertical distance between the upper surface of the drip plate 210 and the upper surface of the microneedle mold 900. Thus, in combination with the thickness of the drip plate 210 itself in the direction of the first axis A1, the glue thickness can be adjusted.

[0057] Further, the base 120 has a mold positioning groove, and the microneedle mold 900 is accommodated in the mold positioning groove. In an exemplary embodiment, after the microneedle mold 900 is loaded into the mold positioning groove, the upper surface of the microneedle mold 900 is flush with the upper surface of the height adjustment plate 121, and it can be understood that the glue coating thickness at this time is the thickness of the leakage plate 210.

[0058] Optionally, the leakage plate assembly 200 is movably arranged on the shell 110 along the first axis A1, and the leakage plate assembly 200 abuts against the base 120 no later than the shell 110 when the shell 110 moves towards the base 120. In order to facilitate the insertion and removal of the microneedle mold 900, the leakage plate assembly 200 can be arranged on the shell 110 and can move along the first axis A1 together with the shell 110. However, since the shell 110 needs to be in contact with and sealed with the base 120, generally, a flexible sealing ring such as a rubber ring or a silicone ring is arranged between the shell 110 and the base 120. In order not to hinder the reliable sealing of the shell 110 and the base 120 due to the abutment of the leakage plate assembly 200 and the base 120 (or the height adjustment plate 121), the leakage plate assembly 200 is movably arranged on the shell 110 along the first axis A1, so as to decouple the movement of the leakage plate assembly 200 and the shell 110 along the first axis A1. The leakage plate assembly 200 abutting against the base 120 no later than the shell 110 means that the leakage plate assembly 200 has abutted against the base 120 (for example, the lower surface of the leakage plate 210 abuts against the upper surface of the height adjustment plate 121) before the shell 110 moves towards the base 120 and abuts against the base 120. At this time, the leakage plate assembly 200 cannot continue to move towards the base 120, but the shell 110 can continue to move towards the base 120 until the shell 110 abuts against the base 120, and the two are sealed by the flexible sealing ring.

[0059] Please refer to Figure 5 and Figure 6 In an exemplary embodiment, the leakage plate assembly 200 includes a guide column 240, which is arranged through the shell 110 in a direction parallel to the first axis A1 and is preferably connected to the shell 110 by a sealing ring. One end of the guide column 240 (the lower end in Figure 5 and Figure 6 ) connected to the connecting seat 230, and the other end protrudes out of the shell 110 and abuts against the shell 110 through an enlarged abutting portion 241. In this way, the downward freedom of the leakage plate assembly 200 relative to the shell 110 is limited, but the upward freedom of the leakage plate assembly 200 is not limited. When the shell 110 moves towards the base 120, Figure 5 and Figure 6When the shell 110 moves towards the base 120, the guiding column 240 and the connecting seat 230 move upwards relative to the shell 110, so that the shell 110 moves towards the base 120 until abutting against the base 120 while the shunt plate assembly 200 keeps abutting against the base 120.

[0060] Optionally, the microneedle glue coating and filling system comprises a first potential energy component 410, the shunt plate assembly 200 is connected with the shell 110 through the first potential energy component 410; when the shell 110 moves towards the base 120 and the shunt plate assembly 200 does not abut against the base 120, the shunt plate assembly 200 moves with the shell 110; after the shunt plate assembly 200 abuts against the base 120, the shell 110 continues to move towards the base 120 to store energy in the first potential energy component 410, and the first potential energy component 410 applies a potential force towards the base 120 to the shunt plate assembly 200. The first potential energy component 410 can reliably press the shunt plate assembly 200 against the base 120, thereby ensuring the flatness of the glue coating and improving the glue coating quality. In an alternative example, the first potential energy component 410 comprises a first spring 411, for example, which is sleeved outside the guiding column 240, and the two ends of the first spring 411 are connected with the shell 110 and the connecting seat 230, respectively.

[0061] Please continue to refer to Figure 3 , Figure 5 and Figure 6 Optionally, the rotary glue coating assembly 300 comprises a glue coating head 310 and a support 320, the support 320 is rotatably arranged in the shell 110 with the first axis A1 as the rotation axis, and the support 320 rotates around the first axis A1 to drive the glue coating head 310 to abut against the shunt plate 210; the microneedle glue coating and filling system comprises a second potential energy component 420, the glue coating head 310 is movably connected with the support 320 along the direction of the first axis A1 through the second potential energy component 420; after the shunt plate assembly 200 abuts against the base 120, the shell 110 continues to move towards the base 120 to store energy in the second potential energy component 420, and the second potential energy component 420 applies a potential force towards the shunt plate 210 to the glue coating head 310.

[0062] Since the leakage plate assembly 200 is movable relative to the housing 110, the leakage plate assembly 200, when moving, can cause the glue head 310 to undesirably separate from the leakage plate 210. However, the second potential energy component 420 can reliably press the glue head 310 against the leakage plate 210, thereby ensuring the flatness of the glue coating and improving the glue coating quality. In an alternative exemplary embodiment, the support 320 is rotatably penetrated through the housing 110 about the first axis Al, and the support 320 has a flow channel for the glue flow. The support 320 is preferably connected with the housing 110 by a sealing ring. The position of the support 320 along the first axis Al relative to the housing 110 is limited, i.e. the support 320 can only rotate relative to the housing 110 and cannot move along the first axis Al. Further, the support 320 is connected with the glue head 310 by a flexible connecting pipe 510. The second potential energy component 420, for example, includes a second spring 421, two ends of which are connected with the glue head 310 and the support 320, respectively. It can be understood that, after the leakage plate assembly 200 abuts against the base 120, the housing 110 continues to move toward the base 120 (i.e. downward), the position of the leakage plate assembly 200 is blocked by the base 120 and cannot continue to move downward, at this time, the housing 110 drives the support 320 to continue to move toward the base 120, the second spring 421 is compressed and exerts a spring force on the glue head 310, so that the glue head 310 is reliably pressed against the leakage plate 210.

[0063] Optionally, the micro-needle glue coating and filling system includes a glue amount adjusting assembly 500, which is configured to periodically change the glue coating amount of the rotating glue coating assembly 300 as the rotating glue coating assembly 300 rotates about the first axis Al. Further, the glue amount adjusting assembly 500 has a closed state and an open state, in the closed state of the glue amount adjusting assembly 500, the glue flow in the rotating glue coating assembly 300 is stopped, in the open state of the glue amount adjusting assembly 500, the glue flow in the rotating glue coating assembly 300 is allowed. Of course, in some embodiments, the glue amount adjusting assembly 500 can also be in a certain intermediate state between the closed state and the open state, and the present application is not limited in this regard.

[0064] Please refer to Figure 7 and Figure 8 , and refer to Figure 5 and Figure 6In an alternative exemplary embodiment, the glue amount adjusting assembly 500 is a mechanical adjusting assembly which does not need additional control and can automatically realize periodic adjustment when the rotary glue applying assembly 300 rotates around the first axis Al. Specifically, the glue amount adjusting assembly 500 comprises a flexible connecting pipe 510, a limiting member 520 and a clamping member 530. The flexible connecting pipe 510 is connected with the glue applying head 310 and the support 320 respectively. The limiting member 520 is arranged on the housing 110. The clamping member 530 is movably arranged on the support 320 along a direction which is at an angle to the first axis Al and rotates with the support 320 to periodically abut against or separate from the limiting member 520. When the clamping member 530 abuts against the limiting member 520, the clamping member 530 extrudes the flexible connecting pipe 510 to reduce the flow cross-sectional area of the flexible connecting pipe 510. When the clamping member 530 separates from the limiting member 520, the clamping member 530 releases the extrusion on the flexible connecting pipe 510. Further, when the clamping member 530 extrudes the flexible connecting pipe 510, the flow cross-sectional area of the flexible connecting pipe 510 can be reduced to zero, i.e. the flow of glue in the rotary glue applying assembly 300 is stopped, and at this time the glue amount adjusting assembly 500 is in a closed state. Conversely, when the clamping member 530 releases the extrusion on the flexible connecting pipe 510, the flow cross-sectional area of the flexible connecting pipe 510 can recover to the maximum inner cross-sectional area, and at this time the glue amount adjusting assembly 500 is in an open state.

[0065] In Figure 7 and Figure 8 In the exemplary embodiment shown, the flexible connecting pipe 510 is arranged along the first axis Al, but it should be understood that the flexible connecting pipe 510 can be bent or twisted and does not necessarily extend strictly along the first axis Al due to its flexibility.

[0066] The clamping member 530 is movably arranged on the support 320 along a direction which is perpendicular to the first axis Al and is limited in the circumferential position relative to the support 320, so that the support 320 rotates around the first axis Al to drive the clamping member 530 to rotate. When the clamping member 530 rotates to the circumferential position which is aligned with the limiting member 520, the clamping member 530 abuts against the limiting member 520 and is pushed by the limiting member 520 to move towards the first axis Al, thereby extruding the flexible connecting pipe 510. When the clamping member 530 continues to rotate to separate from the limiting member 520, the clamping member 530 is no longer limited by the limiting member 520 and can recover to the initial position, thereby releasing the extrusion on the flexible connecting pipe 510.

[0067] In one example, the bracket 320 comprises a clamping member through hole 321 which is opened along a direction perpendicular to the first axis A1, and the clamping member 530 is movably penetrated in the clamping member through hole 321. Further, the clamping member 530 has a guide slot 531 which is opened along a direction of the clamping member 530, and the bracket 320 further comprises a guide pin 322 which is movably penetrated in the guide slot 531 to guide the movement of the bracket 320 along a direction perpendicular to the first axis A1, and to limit the stroke of the bracket 320.

[0068] Preferably, the glue amount adjusting assembly 500 comprises at least two limiting members 520 and at least two clamping members 530, the at least two limiting members 520 are evenly arranged around the first axis A1 in a circumferential direction, and the at least two clamping members 530 are evenly arranged around the first axis A1 in a circumferential direction. Preferably, the number of the limiting members 520 and the clamping members 530 is two.

[0069] Preferably, the glue amount adjusting assembly 500 comprises a third potential energy component 430, the clamping member 530 is connected with the bracket 320 through the third potential energy component 430; when the clamping member 530 is rotated with the bracket 320 from being separated from the limiting member 520 to abutting against the limiting member 520, the third potential energy component 430 is energized; when the clamping member 530 is rotated with the bracket 320 from abutting against the limiting member 520 to being separated from the limiting member 520, the third potential energy component 430 is de-energized to drive the clamping member 530 to move away from the first axis A1 to release the extrusion on the flexible connecting pipe 510. The third potential energy component 430 can reliably release the extrusion on the flexible connecting pipe 510 when the clamping member 530 is rotated with the bracket 320 to be separated from the limiting member 520, and can ensure the reliable flow of the glue. The third potential energy component 430 comprises a third spring 431 for example, the third spring 431 can be sleeved outside the clamping member 530, and the two ends of the third spring 431 are connected with the clamping member 530 and the bracket 320 respectively.

[0070] It can be understood that the first spring 411, the second spring 421 and the third spring 431 are only examples of the first potential energy component 410, the second potential energy component 420 and the third potential energy component 430, and are not limitations of the first potential energy component 410, the second potential energy component 420 and the third potential energy component 430. In other embodiments, the first potential energy component 410, the second potential energy component 420 and the third potential energy component 430 can also comprise potential energy elements such as homopolar opposite magnets, and those skilled in the art can understand and configure according to the prior art, and the present application is not limited thereto.

[0071] The clamping member 530 is provided with a pulley 532 at the end abutting against the limiting member 520, and the clamping member 530 abuts against the limiting member 520 through the pulley 532. Optionally, the rotation axis of the pulley 532 is parallel to the first axis A1, and in this way, the resistance when the clamping member 530 abuts against the limiting member 520 can be reduced. Of course, in some other embodiments, the abutting part of the clamping member 530 and the limiting member 520 can also be provided with a smooth curved surface or an inclined surface, so as to reduce the abutting resistance.

[0072] Please refer to Figure 9 In another embodiment, the glue amount adjusting assembly 500 is an active control type adjusting assembly, which can be controlled based on a control signal to automatically realize periodic adjustment when the rotary glue applying assembly 300 rotates around the first axis A1. Specifically, the glue amount adjusting assembly 500 comprises a flexible connecting pipe 510 and a clamping jaw 540, which is provided outside the flexible connecting pipe 510 and can be an electromagnetic clamping jaw or a pneumatic clamping jaw. After receiving the control signal, the clamping jaw 540 can be opened or closed, so as to adjust the flow area of the flexible connecting pipe 510 or switch the glue amount adjusting assembly 500 between the open state and the closed state.

[0073] Please refer to Figures 1 to 3 Optionally, the micro-needle glue applying and filling system further comprises a driving assembly 600, which is used to drive the rotary glue applying assembly 300 to rotate around the first axis A1, and the driving assembly 600 is provided outside the negative pressure chamber 100. The driving assembly 600 is provided outside the negative pressure chamber 100, which is beneficial to reduce the volume of the entire micro-needle glue applying and filling system.

[0074] In an alternative example, the driving assembly 600 comprises a torque motor 610, a first gear 620 and a second gear 630. The first gear 620 is provided on the output shaft of the torque motor 610, and the second gear 630 is provided at the part of the rotary glue applying assembly 300 extending out of the housing 110, for example, on the support 320. The torque motor 610 is a step motor, and the first gear 620 and the second gear 630 are, for example, helical gears engaged with each other. In this way, the power output by the torque motor 610 can be transmitted to the support 320 through the first gear 620 and the second gear 630, so as to drive the entire rotary glue applying assembly 300 to rotate around the first axis A1. It can be understood that the above example is only an example of the driving assembly 600, and is not a limitation on the driving assembly 600. In some other embodiments, the torque motor 610 can also be a servo motor, and the driving assembly 600 can comprise a belt transmission or other transmission structure, and the present embodiment is not limited in this regard.

[0075] Optionally, the micro-needle glue coating and filling system further comprises a lifting assembly 700 for driving the shell 110 to move along the first axis A1 relative to the base 120. In an alternative example, the lifting assembly 700 comprises a pneumatic cylinder 710 (or an electric cylinder) arranged on the base 120. Optionally, the lifting assembly 700 further comprises a plurality of guiding components, such as linear bearings 721 and lifting columns 722.

[0076] Optionally, the micro-needle glue coating and filling system further comprises a control unit for sending control signals to the driving assembly 600 and the lifting assembly 700 to control the rotation of the rotary glue coating assembly 300 and the lifting of the shell 110.

[0077] Based on the micro-needle glue coating and filling system as described above, the embodiments of the present application further provide a micro-needle glue coating and filling preparation method, which comprises the following steps:

[0078] Step S1: placing the micro-needle mold 900 on the base 120 in the base assembly 1.

[0079] Step S2: driving the shell 110 to move along the first axis A1 towards the base 120 (i.e. downwards) by the lifting assembly 700 until the lower surface of the cathode plate assembly 200 contacts the height adjustment plate 121, and the cathode plate assembly 200 reaches the working position. Then, the lifting assembly 700 continues to drive the shell 110 to move downwards until the shell 110 contacts the base 120, forming a sealed cavity.

[0080] Step S3: starting the vacuum pump 815, and opening the first vacuum valve 811 and the second vacuum valve 812 while closing the third vacuum valve 813 and the fourth vacuum valve 814 to perform air extraction on the cavity in the negative pressure chamber 100 and the glue storage barrel 821 until a specified vacuum degree is reached.

[0081] Step S4: closing the first vacuum valve 811 and the second vacuum valve 812 and stopping the vacuum pump 815 to maintain the negative pressure state of the cavity in the negative pressure chamber 100 and the glue storage barrel 821.

[0082] Step S5: opening the third vacuum valve 813 to form a pressure difference between the upper part of the glue in the glue storage barrel 821 and the negative pressure chamber 100, and when the pressure difference reaches the requirement, the third vacuum valve 813 is closed again, and the pressure difference drives the glue in the glue storage barrel 821 to be sucked into the negative pressure chamber 100 through the rotary glue coating assembly 300.

[0083] Step S6: the glue amount adjusting assembly 500 is initially in a closed state, for example Figure 7 the state shown in the figure, the clamping member 530 abuts against the limiting member 520, the clamping member 530 extrudes the flexible connecting pipe 510 to cause the flow passage cross-sectional area of the flexible connecting pipe 510 to decrease, or the flexible connecting pipe 510 is closed.

[0084] Step S7: The driving assembly 600 drives the spin-coating assembly 300 to rotate one circle in the forward direction around the first axis A1 (it should be understood that the forward direction and the reverse direction herein are only a set of opposite rotation directions, and are not limited to clockwise or counterclockwise). During the process, the glue amount adjusting assembly 500 periodically changes the glue amount of the spin-coating assembly 300.

[0085] Step S8: The driving assembly 600 drives the spin-coating assembly 300 to rotate one circle in the reverse direction around the first axis A1. During the process, the glue amount adjusting assembly 500 periodically changes the glue amount of the spin-coating assembly 300.

[0086] Optionally, the step S7 and / or the step S8 can be repeated several times until the surface of the microneedle mold 900 is evenly and smoothly coated with glue, i.e., the glue coating and filling is completed.

[0087] Step S9: The third vacuum valve 813 and the fourth vacuum valve 814 are both opened, the glue storage barrel 821 and the negative pressure chamber 100 are broken, and the initial normal pressure state is restored.

[0088] Step S10: The first vacuum valve 811 and the second vacuum valve 812 are opened, and the third vacuum valve 813 and the fourth vacuum valve 814 are closed.

[0089] Step S11: The lifting assembly 700 drives the shell 110 to move away from the base 120 (i.e., upward), so that the shell 110 is separated from the base 120.

[0090] Step S12: The microneedle mold 900 which has completed the glue coating and filling is taken out.

[0091] In summary, the microneedle glue coating and filling system comprises a negative pressure chamber, a sieve plate assembly and a rotary glue coating assembly; the negative pressure chamber is used for accommodating and carrying a microneedle mold and is connected with a negative pressure end to form a negative pressure; the sieve plate assembly is arranged in the negative pressure chamber; the sieve plate assembly comprises a sieve plate and an accommodating cavity; the accommodating cavity is opened along the direction of a first axis, and the sieve plate is arranged at one end of the accommodating cavity along the direction of the first axis; the sieve plate has a through hole matched with the shape and position of the microneedle mold, and the through hole is communicated with the accommodating cavity; the rotary glue coating assembly is rotatably penetrated into the accommodating cavity along the first axis and abuts against the sieve plate; the rotary glue coating assembly is used for glue coating under the action of the negative pressure of the negative pressure chamber and scraping the coated glue to the surface of the microneedle mold through the through hole by rotating around the first axis. In this way, on the one hand, the rotary glue coating assembly scrapes the coated glue to the surface of the microneedle mold through the through hole by rotating around the first axis, which can effectively control the consistency of the glue coating thickness and the planar size of the surface of the microneedle mold, and at the same time, since the glue is coated by rotating, the excess glue can be reserved in the accommodating cavity and reused when the next microneedle mold is coated, thereby effectively reducing the waste of glue. On the other hand, the rotary glue coating assembly is based on negative pressure glue coating, the glue coating amount is controllable, and the product consistency is good.

[0092] It should be noted that the above several embodiments can be combined with each other. The above description is only a description of the preferred embodiments of the present application, and does not limit the scope of the present application in any way. Any modification or modification of the above-mentioned disclosure by a person skilled in the art falls within the protection scope of the present application.

Claims

1. A microneedle coating and filling system, characterized by, The micro-needle coating and filling system comprises: a negative pressure chamber, a leakage plate assembly, and a rotary coating assembly; the negative pressure chamber is used for accommodating and carrying a micro-needle mold and connecting with a negative pressure end to form a negative pressure; the leakage plate assembly is arranged in the negative pressure chamber; the leakage plate assembly comprises a leakage plate and an accommodating cavity; the accommodating cavity is opened along a first axis; the leakage plate is arranged at one end of the accommodating cavity along the first axis; the leakage plate has a through hole matched with the shape and position of the micro-needle mold, and the through hole is communicated with the accommodating cavity; the rotary coating assembly is rotatably arranged in the accommodating cavity along the first axis and abuts against the leakage plate; the rotary coating assembly is used for coating under the action of the negative pressure of the negative pressure chamber and scraping the coated glue to the surface of the micro-needle mold through the through hole by rotating around the first axis; the negative pressure chamber comprises a shell and a base; the base is used for carrying the micro-needle mold; the shell is used for moving relative to the base along the first axis to abut against or separate from the base; when the shell abuts against the base, a closed cavity is formed and the micro-needle mold is covered; the leakage plate assembly is movably arranged in the shell along the first axis; when the shell moves towards the base, the leakage plate assembly abuts against the base not later than the shell.

2. The microneedle coating and filling system of claim 1, wherein, The micro-needle coating and filling system comprises a first potential energy component; the leakage plate assembly is connected with the shell through the first potential energy component; when the shell moves towards the base and the leakage plate assembly does not abut against the base, the leakage plate assembly moves with the shell; after the leakage plate assembly abuts against the base, the shell continues to move towards the base to store energy of the first potential energy component; the first potential energy component applies a potential force to the leakage plate assembly towards the base.

3. The microneedle coating and filling system of claim 1, wherein, The rotary coating assembly comprises a coating head and a support; the support is rotatably arranged in the shell along the first axis; when the support rotates around the first axis, the coating head abuts against the leakage plate and rotates; The micro-needle coating and filling system comprises a second potential energy component; the coating head is movably connected with the support along the first axis through the second potential energy component; after the leakage plate assembly abuts against the base, the shell continues to move towards the base to store energy of the second potential energy component; the second potential energy component applies a potential force to the coating head towards the leakage plate.

4. The microneedle coating and filling system of claim 1, wherein, The base comprises a height adjustment plate; the height adjustment plate is used for abutting against the lower surface of the leakage plate; the height adjustment plate and / or the leakage plate are replaceable; the thickness of the height adjustment plate and / or the leakage plate along the first axis is used to adapt to adjust the vertical distance between the upper surface of the leakage plate and the upper surface of the micro-needle mold.

5. The microneedle coating and filling system of claim 1, wherein, The micro-needle coating and filling system comprises a glue amount adjusting assembly; the glue amount adjusting assembly is configured to periodically change the coating amount of the rotary coating assembly when the rotary coating assembly rotates around the first axis.

6. The microneedle coating and filling system of claim 5, wherein, The negative pressure chamber comprises a shell, and the rotary coating assembly comprises a coating head and a support; the support is rotatably penetrated through the shell with the first axis as a rotation axis; The glue amount adjusting assembly comprises a flexible connecting pipe, a limiting piece and a clamping piece; The flexible connecting pipe is connected with the coating head and the support respectively; the limiting piece is arranged on the shell, and the clamping piece is movably arranged on the support in a direction at an angle to the first axis and rotates with the support to periodically abut against or separate from the limiting piece; When the clamping piece abuts against the limiting piece, the clamping piece extrudes the flexible connecting pipe to reduce the flow area of the flexible connecting pipe; When the clamping piece separates from the limiting piece, the clamping piece releases the extrusion on the flexible connecting pipe.

7. The microneedle glue-coated filling system according to claim 6, wherein, The glue amount adjusting assembly comprises a third potential energy component, and the clamping piece is connected with the support through the third potential energy component; when the clamping piece rotates with the support from separating from the limiting piece to abutting against the limiting piece, the third potential energy component stores energy; When the clamping piece rotates with the support from abutting against the limiting piece to separating from the limiting piece, the third potential energy component releases energy to drive the clamping piece to move away from the first axis to release the extrusion on the flexible connecting pipe.

8. The microneedle coating and filling system of claim 6, wherein, The end of the clamping piece for abutting against the limiting piece is provided with a pulley, and the clamping piece abuts against the limiting piece through the pulley.

9. The microneedle coating and filling system of claim 1, wherein, The rotary coating assembly comprises a coating head, and the glue outlet of the coating head is in the form of a strip extending in a direction perpendicular to the first axis; and / or, the outer contour of the part of the coating head penetrating into the accommodating cavity is in the form of a strip extending in a direction perpendicular to the first axis.

10. The microneedle coating and filling system of claim 9, wherein, The extension length of the strip of the coating head or the glue outlet is matched with the inner diameter of the accommodating cavity.

11. The microneedle coating and filling system of claim 1, wherein, The microneedle coating and filling system further comprises a driving assembly for driving the rotary coating assembly to rotate around the first axis; wherein the driving assembly is arranged outside the negative pressure chamber.

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