Curcumin-based ionic liquid liposome and preparation method and application thereof

Abstract

The application discloses a curcumin-based ionic liquid liposome and a preparation method and application thereof. The preparation method of the curcumin-based ionic liquid liposome comprises the following steps: reacting curcumin with succinic anhydride to obtain curcumin succinate; reacting the curcumin succinate with betaine and L-carnitine to obtain a curcumin-based ionic liquid; and mixing the curcumin-based ionic liquid with lipids, and obtaining the curcumin-based ionic liquid liposome through an ethanol injection method. The curcumin-based ionic liquid liposome has good biocompatibility, improves the solubility and bioavailability of curcumin, so that the curcumin-based ionic liquid liposome can promote the penetration of the curcumin into the stratum corneum and has the effects of antioxidation, anti-inflammation and antitumor on the skin.

Description

Technical Field

[0001] The present invention relates to the technical field of liposomes, and in particular to a curcumin-based ionic liquid liposome and a preparation method and application thereof. Background Art

[0002] In recent years, liposome technology has begun to be applied in the cosmetics, pharmaceutical, and life sciences fields. Compared with traditional liposome preparation methods, the most prominent advantage of ionic liquid liposomes is that ionic liquid molecules can be linked by forces, resulting in double or greater efficacy. As a novel preparation technology, ionic liquid liposome technology offers advantages such as permeability through the stratum corneum, increased solubility, improved stability and bioavailability, and avoidance of the first-pass effect in the liver, making it an excellent approach for the cosmetics, pharmaceutical, and life sciences fields.

[0003] In ionic liquid liposome technology, the interaction between ionic liquids not only allows them to effectively penetrate the stratum corneum of the skin, but also can be used as active ingredients to improve their bioavailability and exert their effects. Transdermal drug delivery has many advantages over traditional drug delivery strategies (oral, injection), such as avoiding first-pass liver clearance, improving patients' dependence on drugs and reducing side effects. However, due to the insolubility or slight solubility of large molecules or poorly soluble drugs in water and most organic solvents, transdermal delivery is difficult. As we all know, the delivery of large molecule drugs is difficult and their bioavailability is low, and they have never entered the clinical trial stage.

[0004] Therefore, the existing technology still needs to be improved and developed. Summary of the Invention

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a curcumin-based ionic liquid liposome and a preparation method and application thereof, aiming to solve the problem of improving the solubility and bioavailability of curcumin to achieve transdermal delivery.

[0006] The first aspect of the present invention provides a method for preparing curcumin-based ionic liquid liposomes, which comprises the steps of:

[0007] reacting curcumin with succinic anhydride to obtain curcumin succinate;

[0008] reacting the curcumin succinate with betaine and L-carnitine to obtain a curcumin-based ionic liquid;

[0009] The curcumin-based ionic liquid is reacted with lipid to obtain curcumin-based ionic liquid liposomes.

[0010] Optionally, the step of reacting curcumin with succinic anhydride to obtain curcumin succinate specifically comprises:

[0011] Curcumin and succinic anhydride are added to a first solvent, and reacted at a first predetermined temperature for a first predetermined time to obtain curcumin succinate.

[0012] Optionally, the molar ratio of the curcumin to the succinic anhydride is 1:1-1:10;

[0013] The first solvent is selected from at least one of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butylene glycol, and pentanediol.

[0014] Optionally, the first predetermined temperature is 30-100° C., and the first predetermined time is 4-24 hours.

[0015] Optionally, the step of reacting the curcumin succinate with betaine and L-carnitine to obtain a curcumin-based ionic liquid specifically comprises:

[0016] The curcumin succinate, betaine and L-carnitine are added to a second solvent, reacted at a second predetermined temperature for a second predetermined time, and after the reaction is completed, concentrated and recrystallized to obtain the curcumin-based ionic liquid.

[0017] Optionally, the molar ratio of the curcumin succinate to the total molar ratio of the betaine and L-carnitine is 1:1-1:10, and the molar ratio of the betaine to the L-carnitine is 1:1-1:10.

[0018] Optionally, the second solvent is selected from at least one of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butanediol, and pentanediol;

[0019] The second predetermined temperature is 30-100° C., and the second predetermined time is 4-48 hours.

[0020] Optionally, the step of reacting the curcumin-based ionic liquid with lipids to obtain curcumin-based ionic liquid liposomes specifically comprises:

[0021] adding the curcumin-based ionic liquid and lipid to a third solvent, reacting at a third predetermined temperature for a third predetermined time, and concentrating and recrystallizing after the reaction to obtain the curcumin-based ionic liquid liposomes;

[0022] The lipid is selected from one or more of soybean lecithin, cholesterol, Tween-20, Tween-40, Tween-60, Tween-80, Span-20, and Span-80;

[0023] The third solvent is one or more of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butanediol, and pentanediol;

[0024] Mixing the curcumin-based ionic liquid and lipid in a molar ratio of 1:1-1:10;

[0025] The third predetermined temperature is 30-100° C., and the third predetermined time is 4-48 hours.

[0026] In a second aspect of the present invention, a curcumin-based ionic liquid liposome is provided, wherein the curcumin-based ionic liquid liposome is prepared using the preparation method of the curcumin-based ionic liquid liposome according to the present invention.

[0027] In a third aspect, the present invention provides an application of a curcumin-based ionic liquid liposome, wherein the curcumin-based ionic liquid liposome is used as a raw material for formulations of cosmetics, medicine, and life sciences; or, the curcumin-based ionic liquid liposome is used as a pharmaceutical ingredient for transdermal drug delivery.

[0028] Beneficial effects: The curcumin-based ionic liquid liposomes prepared by the above method have good biocompatibility, improve the solubility and bioavailability of curcumin, and greatly improve its transdermal absorption effect; and the curcumin-based ionic liquid liposomes completely retain the main molecular skeleton of curcumin monomers and lipids, so that the biological activity and efficacy of the curcumin-based ionic liquid liposomes are improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The present invention provides a flow chart of a method for preparing curcumin-based ionic liquid liposomes.

[0030] Figure 2 This is the H NMR spectrum of curcumin succinate and curcumin-based ionic liquid prepared in Example 1 of the present invention.

[0031] Figure 3 This is a two-dimensional H-NMR spectrum of the curcumin-based ionic liquid prepared in Example 1 of the present invention.

[0032] Figure 4 This is a transmission electron micrograph of the curcumin-based ionic liquid liposomes prepared in Example 1 of the present invention.

[0033] Figure 5 This is a diagram of the transdermal efficiency of the curcumin-based ionic liquid liposomes prepared in Example 1 of the present invention.

[0034] Figure 6 This is a graph showing the cell viability of the curcumin-based ionic liquid liposomes prepared in Example 1 of the present invention.

[0035] Figure 7 This is a solubility diagram of the curcumin-based ionic liquid liposomes prepared in Example 1 of the present invention. DETAILED DESCRIPTION

[0036] The present invention provides a curcumin-based ionic liquid liposome and its preparation method and application. To make the purpose, technical solution and effect of the present invention clearer and more specific, the present invention is further described in detail below. It should be understood that the specific embodiments described herein are only used to illustrate the present invention and are not intended to limit the present invention.

[0037] See also Figure 1 The present invention provides a method for preparing curcumin-based ionic liquid liposomes, which comprises the following steps:

[0038] S100, reacting curcumin with succinic anhydride to obtain curcumin succinate;

[0039] S200, reacting the curcumin succinate with betaine and L-carnitine to obtain a curcumin-based ionic liquid;

[0040] S300, reacting the curcumin-based ionic liquid with lipid to obtain curcumin-based ionic liquid liposomes.

[0041] Specifically, in this embodiment, curcumin and succinic anhydride are first subjected to an esterification reaction to obtain curcumin succinate. This curcumin succinate can not only improve the designability and modifiability of curcumin, but also improve the solubility of curcumin. Subsequently, curcumin succinate is used as an anion precursor, betaine and L-carnitine are used as cationic precursors, and a curcumin-based ionic liquid is obtained through an ionization salt reaction. Finally, the curcumin-based ionic liquid and lipid are injected into the ethanol to obtain curcumin-based ionic liquid liposomes. This preparation method can use simple and readily available solvents such as ethanol or water as the reaction medium. The instruments and reaction conditions used are also easy to implement. The synthesis steps are simple, the post-processing is convenient, the obtained product has high purity and high yield, and can meet general research requirements.

[0042] The curcumin-based ionic liquid liposomes prepared by the above-mentioned preparation method in this embodiment have excellent properties such as good biocompatibility, good solubility, high bioavailability and good skin permeability; and the curcumin-based ionic liquid liposomes completely retain the main molecular skeleton of lipids while retaining the biological activity and efficacy of curcumin.

[0043] Curcumin is the most important chemical component of the plant turmeric for its pharmacological effects, inhibiting inflammation, oxidation, and anti-cancer properties. Betaine has anti-tumor, blood pressure-lowering, anti-peptic ulcer and gastrointestinal dysfunction, and liver disease-treating properties. It also regulates osmotic pressure, alleviates stress, and promotes fat metabolism and protein synthesis. L-carnitine can protect cell membrane stability, enhance immunity, and protect against certain diseases. It plays a preventative role in the prevention and treatment of sub-health conditions and is primarily used in the healthcare, life science, pharmaceutical, and cosmetics industries.

[0044] In one embodiment of the present invention, S100 specifically includes: adding curcumin and succinic anhydride into a first solvent, reacting at a first predetermined temperature for a first predetermined time to obtain curcumin succinate.

[0045] In one embodiment of the present invention, the reaction is carried out under magnetic stirring.

[0046] In one embodiment of the present invention, the molar ratio of curcumin to succinic anhydride is 1:1-1:10. For example, the molar ratio of curcumin to succinic anhydride can be 1:1, 1:2, 1:3, 1:4, 1:5, 1:10, etc.

[0047] In one embodiment of the present invention, the first predetermined temperature is 30-100° C., and the first predetermined time is 4-24 hours. At this reaction temperature, a relatively fast reaction rate is achieved while effectively suppressing the occurrence of side reactions; and within this reaction time, the complete reaction between curcumin and succinic anhydride can be promoted.

[0048] In one embodiment of the present invention, S200 specifically includes: adding the curcumin succinate, betaine, and L-carnitine to a second solvent, reacting at a second predetermined temperature for a second predetermined time, and after the reaction is completed, separating and purifying the product by concentration and recrystallization to obtain the curcumin-based ionic liquid.

[0049] The curcumin succinate reacts with betaine and L-carnitine to form an ionized salt, yielding a curcumin-based ionic liquid. The curcumin-based ionic liquid combines the biological activities and efficacy of curcumin, betaine, and L-carnitine, significantly improving the solubility and bioavailability of curcumin and enhancing its application effectiveness.

[0050] The curcumin has a unique skin-protecting effect, keeping the skin moisturized, smooth, delicate, and elastic, and has antioxidant, anti-inflammatory, anti-wrinkle, beauty, and health-care effects, as well as skin-restoring physiological functions. The betaine or L-carnitine can generate a natural protective component in the outer layer of cells, which also has a good repair and protective effect on the skin. The curcumin-based ionic liquid liposomes simultaneously possess the biological activities and efficacy of curcumin, betaine, and L-carnitine, and greatly improve the solubility and transdermal penetration of curcumin, thereby enhancing its application effect.

[0051] In one embodiment of the present invention, the second solvent is selected from at least one of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butanediol, pentanediol and the like.

[0052] In the process of preparing the curcumin-based ionic liquid in this embodiment, the use of the above solvent can improve the recrystallization separation effect of the product.

[0053] In one embodiment of the present invention, after the reaction is completed, the reaction system is concentrated to 1 / 5 to 1 / 10 of its volume under vacuum conditions, and then recrystallized by reduced pressure distillation to obtain a pure curcumin-based ionic liquid.

[0054] In one embodiment of the present invention, after the concentration and recrystallization, the process further comprises the steps of filtering and separating the system obtained by recrystallization and vacuum drying in sequence to obtain the curcumin-based ionic liquid; wherein the drying time is 24-48 hours to completely remove the remaining water or ethanol or other second solvent in the product.

[0055] In one embodiment of the present invention, the molar ratio of the curcumin succinate to the total molar ratio of the betaine and L-carnitine is 1:1-1:10, and the molar ratio of the betaine to the L-carnitine is 1:1-1:10.

[0056] In one embodiment of the present invention, S300 specifically includes: adding the curcumin-based ionic liquid and lipid to a third solvent (such as ethanol), reacting at a third predetermined temperature for a third predetermined time, and after the reaction is completed, separating and purifying the product by concentration and recrystallization to obtain the curcumin-based ionic liquid liposomes.

[0057] The curcumin-based ionic liquid is mixed with lipids and then ethanol injection is performed to obtain curcumin-based ionic liquid liposomes. The preparation method is simple and easy to operate and can meet general research requirements.

[0058] In one embodiment of the present invention, the lipid is selected from one or more of soybean lecithin, cholesterol, Tween-20, Tween-40, Tween-60, Tween-80, Span-20, and Span-80.

[0059] In one embodiment of the present invention, the curcumin-based ionic liquid is mixed with lipid in a molar ratio of 1:1 to 1:10.

[0060] In one embodiment of the present invention, the third predetermined temperature is 30-100° C., and the third predetermined time is 4-48 hours.

[0061] In the preparation method provided in this embodiment, the curcumin exhibits a unique antioxidant effect that protects the skin, keeping it moisturized, smooth, delicate, and elastic. It also exhibits antioxidant, anti-inflammatory, anti-tumor, and skin-restoring properties. The betaine or L-carnitine also has restorative and protective effects on the human body. The curcumin-based ionic liquid liposomes combine the biological activities and efficacy of both curcumin and lipids, significantly improving the solubility and transdermal permeability of curcumin, thereby enhancing its effectiveness. However, the solubility and transdermal permeability of curcumin alone are relatively poor, limiting its effectiveness and scope of application. In the present invention, betaine and L-carnitine are ionized and modified using curcumin succinate as an anion precursor, resulting in a pure, natural curcumin-based ionic liquid with excellent antioxidant, anti-inflammatory, and anti-tumor properties. The resulting curcumin-based ionic liquid not only effectively improves the solubility and skin permeability of curcumin, but also enhances its biological activity, offering potential applications in transdermal drug delivery and transdermal administration.

[0062] The present invention provides a curcumin-based ionic liquid liposome, wherein the curcumin-based ionic liquid liposome is prepared using the above-mentioned preparation method of the curcumin-based ionic liquid liposome, wherein the curcumin-based ionic liquid comprises curcumin succinate, betaine, and L-carnitine.

[0063] The curcumin-based ionic liquid liposomes described in this embodiment have the following effects: first, compared with single curcumin, the curcumin-based ionic liquid liposomes have better biocompatibility and significantly improve their transdermal absorption, thereby enhancing the application effect; second, the curcumin-based ionic liquid liposomes completely retain the molecular skeleton of the curcumin monomer and the lipid properties, and thus have the biological activities and efficacy of both substances.

[0064] The present invention also provides an application of the curcumin-based ionic liquid liposomes, wherein the curcumin-based ionic liquid liposomes described in the present invention are used as raw materials for formulations of cosmetics, pharmaceuticals, and life sciences; or as pharmaceutical ingredients for drugs delivered transdermally. In other words, the curcumin-based ionic liquid liposomes described in this embodiment can be used as raw materials for formulations of pharmaceuticals and cosmetics, or as pharmaceutical ingredients for drugs delivered transdermally.

[0065] In this example, curcumin succinate was used as an anionic precursor to ionize betaine and L-carnitine, generating a curcumin-based ionic liquid. Subsequently, lipids were added and ethanol infusion was used to produce curcumin-based ionic liquid liposomes. These curcumin-based ionic liquid liposomes not only fully retain the main molecular skeleton and functional groups of curcumin, but also the properties of lipids, thereby combining the biological activities and efficacy of both substances. Furthermore, curcumin-based ionic liquid liposomes significantly enhance curcumin's solubility, transdermal absorption, and transdermal delivery.

[0066] The present invention will be further described below by means of specific examples.

[0067] Example 1

[0068] The preparation method of curcumin-based ionic liquid liposomes in this embodiment comprises the following steps:

[0069] Dissolve 0.01 mol of curcumin in 10 mL of water and 10 mL of ethanol in a reactor, dissolve 0.02 mol of succinic anhydride in 10 mL of water, and add the solution dropwise to the reactor containing the curcumin. Heat to 60°C and perform the esterification reaction for 12 hours.

[0070] After the reaction is completed, the solution is concentrated to 1 / 10 of the reaction solution under vacuum conditions, and then distilled under reduced pressure for crystallization. After filtering, washing, and separation, curcumin succinate is obtained. The curcumin succinate with a purity exceeding 99% is obtained by drying in a vacuum drying oven for 48 hours, with a yield of 86.78%.

[0071] like Figure 2 As shown, the H NMR spectrum data of curcumin succinate prepared in this example is: 1 HNMR (400MHz, DMSO) δ8.12 (s, 1H), 7.70-7.61 (m, 2H), 7.30-6.94 (m, 6H), 6.56-6.49 (m, 2H), 6.14 (s, 1H), 5.32 (s, 1H) 3.38 (s, 6H), 2.97-2.32 (t, 2H), 2.70 (t, 2H); 1.25 (s, 1H), 1.127 (s, 1H); C NMR data are: 13C NMR (400 MHz, DMSO) δ 175.13 (s), 173.42 (s), 155.48 (s), 146.03 (s), 107.22 (s), 63.11 (s), 52.52 (s), 51.79 (s), 45.71 (s), 30.99 (s), 30.41 (s), 29.64 (s), 29.24 (s), 27.92 (s), 25.66 (s), 19.51 (s), 9.03 (s), 7.67 (s). The melting point of the curcumin succinate prepared in this example is 273°C.

[0072] Under nitrogen atmosphere, 0.01 mol of curcumin succinate was dissolved in 10 mL of water and 10 mL of ethanol in a reactor. 0.02 mol of betaine and 0.02 mol of L-carnitine were dissolved in 10 mL of water and added dropwise to the reactor containing the curcumin succinate. The mixture was heated to 60°C and ionized to form salts for 12 hours.

[0073] After the reaction is completed, the solution is concentrated to 1 / 10 of the reaction solution under vacuum conditions, and then distilled and crystallized under reduced pressure. The curcumin-based ionic liquid is separated by filtration and washing, and dried in a vacuum drying oven for 48 hours to obtain a curcumin-based ionic liquid with a purity of more than 99% and a yield of 95.14%.

[0074] like Figure 2 As shown, the H NMR spectrum data of the curcumin-based ionic liquid prepared in this embodiment are: 1 HNMR (400MHz, DMSO) δ8.14 (s, 1H), 7.62-7.58 (m, 2H), 7.29-6.85 (m, 6H), 6.43-6.32 (m, 2H), 6.08 (s, 1H), 5.77 (s, 1H) 3.38 (s, 6H), 2.97-2.32 (t, 2H), 2.70 (t, 2H); 0.93-1.35 (m, 4H); C NMR data are: 13 C NMR (400 MHz, DMSO) δ 148.74 (s), 107.06 (s), 66.38 (s), 60.22 (s), 56.70 (s), 56.52 (s), 56.32 (s), 55.98 (s), 52.56 (s), 52.52 (s), 52.48 (s), 45.98 (s), 31.88 (s), 29.58 (s), 29.39 (s), 25.56 (s), 18.91 (s), 18.73 (s), 14.33 (s), 10.32 (s). The melting point of the curcumin-based ionic liquid prepared in this example is 281°C.

[0075] At room temperature, 0.01 mol of curcumin-based ionic liquid was dissolved in 10 mL of ethanol in a reactor. 0.01 mol of soy lecithin and 0.01 mol of cholesterol were dissolved in 10 mL of ethanol and added dropwise to the reactor containing the curcumin-based ionic liquid. The mixture was heated to 40°C, mixed evenly, and reacted for 12 hours.

[0076] After the reaction is completed, the solution is concentrated under vacuum to 1 / 10 of the volume of the reaction solution, and the solution is crystallized by distillation under reduced pressure to obtain curcumin-based ionic liquid liposomes. The curcumin-based ionic liquid liposomes are dried in a vacuum drying oven for 48 hours to obtain curcumin-based ionic liquid liposomes with a purity exceeding 99% and a yield of 89.36%.

[0077] Figure 3 This is the two-dimensional H-NMR spectrum of the curcumin-based ionic liquid prepared in this example.

[0078] Figure 4 This is a transmission electron micrograph of the curcumin-based ionic liquid liposomes prepared in this example.

[0079] The NMR spectra show that curcumin-based ionic liquids can be successfully prepared via ion exchange reactions. The particle size of the curcumin-based ionic liquid liposomes is small, approximately 2 nm, indicating that the liposomes are well mixed.

[0080] The in vitro percutaneous permeation efficiency of curcumin-based ionic liquid liposomes was determined using a Franz diffusion cell. Figure 5 As can be seen from the results, the skin permeability of curcumin-based ionic liquid liposomes is 18.03 times that of curcumin and 1.19 times that of curcumin-based ionic liquid. Therefore, it is shown that curcumin-based ionic liquid liposomes can improve the skin permeability of curcumin.

[0081] In addition, after incubating keratinocytes with curcumin-based ionic liquid liposomes, curcumin-based ionic liquid and curcumin for 24 h, it was found that the cell viability of curcumin-based ionic liquid liposomes was higher than 95%. Figure 6 Therefore, it is shown that curcumin-based ionic liquid liposomes have lower toxicity.

[0082] Subsequently, curcumin was dissolved in curcumin-based ionic liquid liposomes, curcumin-based ionic liquid, ethanol and water respectively, and the solubility of curcumin was tested. The results showed that the solubility of curcumin in curcumin-based ionic liquid liposomes was about 251.2 times higher than that of single curcumin in aqueous solution. Figure 7 shown.

[0083] In summary, the present invention provides a curcumin-based ionic liquid liposome, and its preparation method and application. The present invention uses betaine and L-carnitine as cationic precursors and curcumin succinate as an anionic precursor to synthesize a curcumin-based ionic liquid through an ionization salt-forming reaction. After the reaction is completed, the product is separated and purified by concentration and crystallization; then, the curcumin-based ionic liquid and lipid are injected into the ethanol to obtain curcumin-based ionic liquid liposomes. The curcumin-based ionic liquid liposome has a solubility of curcumin that is approximately 251.2 times higher than that of single curcumin in aqueous solution, and simultaneously has the antioxidant, anti-inflammatory, anti-tumor and repair effects and biological activities of the curcumin-based ionic liquid and single curcumin and lipid.

[0084] It should be understood that the application of the present invention is not limited to the above examples. For those skilled in the art, improvements or changes can be made based on the above description. All these improvements and changes should fall within the scope of protection of the claims attached to the present invention.

Claims

1. A method for preparing curcumin-based ionic liquid liposomes, characterized in that: Including steps: reacting curcumin with succinic anhydride to obtain curcumin succinate; reacting the curcumin succinate with betaine and L-carnitine to obtain a curcumin-based ionic liquid; reacting the curcumin-based ionic liquid with lipids to obtain curcumin-based ionic liquid liposomes; The step of reacting curcumin with succinic anhydride to obtain curcumin succinate specifically comprises: adding curcumin and succinic anhydride to a first solvent, reacting at a first predetermined temperature for a first predetermined time to obtain curcumin succinate; The molar ratio of the curcumin to the succinic anhydride is 1:1-1:10; The first predetermined temperature is 30-100° C., and the first predetermined time is 4-24 hours; The step of reacting the curcumin succinate with betaine and L-carnitine to obtain a curcumin-based ionic liquid specifically comprises: adding the curcumin succinate, betaine, and L-carnitine to a second solvent, reacting at a second predetermined temperature for a second predetermined time, and concentrating and recrystallizing after the reaction to obtain the curcumin-based ionic liquid; The molar ratio of the curcumin succinate to the total molar ratio of the betaine and L-carnitine is 1:1-1:10, and the molar ratio of the betaine to the L-carnitine is 1:1-1:10; The second predetermined temperature is 30-100° C., and the second predetermined time is 4-48 hours; The step of reacting the curcumin-based ionic liquid with lipids to obtain curcumin-based ionic liquid liposomes specifically comprises: adding the curcumin-based ionic liquid and lipid to a third solvent, reacting at a third predetermined temperature for a third predetermined time, and concentrating and recrystallizing after the reaction to obtain the curcumin-based ionic liquid liposomes; Mixing the curcumin-based ionic liquid and lipid in a molar ratio of 1:1-1:10; The third predetermined temperature is 30-100° C., and the third predetermined time is 4-48 hours.

2. The method for preparing curcumin-based ionic liquid liposomes according to claim 1, wherein The first solvent is selected from at least one of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butylene glycol, and pentanediol.

3. The drying method of curcumin-based ionic liquid liposomes according to claim 1, wherein The second solvent is selected from at least one of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butylene glycol, and pentanediol.

4. The drying method of curcumin-based ionic liquid liposomes according to claim 1, wherein The lipid is selected from one or more of soybean lecithin, cholesterol, Tween-20, Tween-40, Tween-60, Tween-80, Span-20, and Span-80; The third solvent is one or more of ethanol, water, methanol, isopropanol, acetone, propylene glycol, butanediol, and pentanediol.

5. A curcumin-based ionic liquid liposome, characterized in that The liposomes are prepared by the method for preparing the curcumin-based ionic liquid liposomes according to any one of claims 1 to 4.

6. An application of curcumin-based ionic liquid liposomes, characterized in that: The curcumin-based ionic liquid liposomes as claimed in claim 5 are used as a formula raw material in the preparation of cosmetics and pharmaceuticals; or the curcumin-based ionic liquid liposomes as claimed in claim 5 are used as a medicinal ingredient in the preparation of transdermal delivery drugs.

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