Multifunctional apparatus and method for preparing frozen pellets

Abstract

The application discloses a multifunctional preparation device and method of frozen small balls. The device comprises a driving system, a droplet system and a plurality of insulated tanks; each of the insulated tanks is filled with a coolant and comprises a droplet inlet; the droplet system comprises at least two droplet pipes, each of the droplet pipes independently discharges a reagent liquid according to a preset time interval and a preset metering, and the droplet pipes can selectively discharge the type of the reagent liquid according to a preset mode; and the driving system drives the relative movement of the droplet system and the insulated tanks to align or stagger each of the droplet pipes and the corresponding insulated tank droplet inlet. The application drives the relative movement of the droplet system and the insulated tanks by the driving system, so that each of the droplet pipes is aligned or staggered with the corresponding insulated tank droplet inlet, and the reagent liquid flows into the insulated tank to be cooled by the coolant to form frozen small balls, thereby achieving the preparation of one or more frozen small balls at the same time, having multifunctionality, and improving the production efficiency.

Description

Technical Field

[0001] This application relates to the field of frozen microsphere preparation equipment technology, specifically to a multifunctional preparation equipment and method for frozen microspheres. Background Technology

[0002] Lyophilized beads, also known as lyophilized microspheres or lyophilized microcores, are small, uniformly shaped solid spheres (i.e., frozen microspheres, an intermediate product of lyophilized beads) rapidly frozen in an extremely short time and at extremely low temperatures by applying reagents / medicinal solutions to a cryogenic liquid medium such as liquid nitrogen or a cryogenic solid surface using a specialized precision micro-pump. These frozen microspheres are then collected and further dehydrated in a lyophilization device to obtain lyophilized beads. Lyophilized bead technology maximizes the preservation of enzyme / protein activity, and the beads possess a loose network structure, allowing for rapid reconstitution. This technology can transform unstable chemical reagents into high-quality, stable, and quantitatively measured lyophilized microspheres, which are used in the storage and transportation of pharmaceuticals and the preservation of cosmetics.

[0003] However, the inventors of this application, through long-term research, have discovered that current equipment requires the following steps: First, a coolant (commonly liquid nitrogen) is placed in an insulated container. Then, the reagent solution is manually dripped into the container. After cooling and forming frozen microspheres within the container, these microspheres are manually packed into various dispensing containers and then rapidly placed in a freeze-drying apparatus for vacuum freeze-drying. This dispensing process must be completed within minutes; otherwise, the frozen microspheres will melt, leading to the failure of freeze-dried microsphere preparation. Alternatively, after preparing the frozen microspheres, they can be placed directly into the freeze-drying apparatus without dispensing, waiting for vacuum freeze-drying to form freeze-dried microspheres before dispensing. However, freeze-dried microspheres are highly hygroscopic, and dispensing them requires rapid operation in an extremely low-humidity environment, resulting in high production costs and operational difficulties. Furthermore, the aforementioned equipment can only prepare one type of frozen microsphere, and cannot prepare multiple types simultaneously, leading to low production efficiency. Summary of the Invention

[0004] This application provides a multifunctional preparation device and method for frozen microspheres to solve the problems of low production efficiency, inability to prepare multiple types of frozen microspheres, high production cost, and difficult operation.

[0005] To solve the above-mentioned technical problems, one technical solution adopted in this application is: a multifunctional preparation device for frozen microspheres, including a driving system, a dripping system and multiple insulated tanks;

[0006] Each of the aforementioned insulated tanks contains a coolant and includes a drip inlet;

[0007] The dripping system includes at least two drip tubes, each drip tube independently dispensing reagent solution according to a preset time interval and a preset metering. The drip tube can select the type of reagent solution to be dispensed according to a preset mode.

[0008] The drive system drives the dripping system and the insulation tank to move relative to each dripping tube until the dripping inlet of the corresponding insulation tank is aligned or offset.

[0009] According to one embodiment of this application, it also includes a human-computer interaction interface, on which the preset mode is displayed.

[0010] According to one embodiment of this application, the dripping system further includes at least two dispensers and a reagent supply device, each dispenser being connected to a corresponding drip tube, and the dispenser being connected to the corresponding reagent supply device according to a selected preset mode.

[0011] According to one embodiment of this application, according to the preset mode, each of the dispensers is connected to a corresponding reagent supply device that supplies the same reagent solution and discharges it simultaneously through the corresponding dropper; or each of the dispensers is connected to a corresponding reagent supply device that supplies different or not completely the same reagent solution and discharges it simultaneously through the corresponding dropper.

[0012] According to one embodiment of this application, it further includes a working frame and a working disc that rotates relative to the working frame, wherein the dripping system is fixed on the working frame; the working disc is provided with a plurality of mounting slots, and each insulation tank is mounted on a corresponding mounting slot; the driving system includes a first driving component, the first driving component drives the working disc to rotate continuously, and the first driving component drives the corresponding insulation tank to move to the dripping inlet of the corresponding insulation tank within a preset time interval.

[0013] According to one embodiment of this application, the mounting slots are arranged in an arc shape and are evenly distributed; the drip tubes are also arranged in an arc shape.

[0014] According to one embodiment of this application, it further includes a packaging bottle, each of which is connected to a corresponding insulation container, and each insulation container is further equipped with a guide component; the guide component includes a guide channel and a connecting hole communicating with the guide channel, the connecting hole being located below the liquid surface of the coolant, and the shape formed by any region of the connecting hole is not equal to or includes a cross section passing through the center of the frozen pellet; the reagent solution of the frozen pellet enters the guide channel through a first port of the guide channel; the second port of the guide channel is connected to the packaging bottle.

[0015] According to one embodiment of this application, each of the heat-insulating tanks includes a mounting through hole, and each of the guiding members is installed in the mounting through hole; the equipment for preparing frozen pellets further includes a fixing frame; the guiding member further includes a mounting plate installed on the fixing frame, and the first port penetrates the mounting plate; the driving system further includes a second driving member, which drives the fixing frame to move so as to cause the guiding member to slide into or out of the mounting through hole.

[0016] According to one embodiment of this application, the fixing frame is fixedly provided with a clamping arm, which extends into the corresponding insulation tank; the packaging bottle is also installed inside the insulation tank; the packaging bottle includes a bottle mouth, the diameter of which is larger than the diameter of the frozen pellets; the guide member includes a neck sleeved on the bottle mouth; the packaging bottle is movably mounted on the clamping arm; the driving system further includes a third driving member, which is connected to the mounting plate and drives the mounting plate to move, thereby moving the neck of the guide member to engage or disengage from the bottle mouth.

[0017] According to one embodiment of this application, the centerline of the guide channel is a straight line, the guide channel includes at least one columnar wall segment and at least one conical wall segment, the columnar wall segment and the conical wall segment are arranged alternately; along the direction from the first port to the second port, the slope of the conical wall segment increases sequentially, and the size of the guide channel decreases; the portion of the guide channel located at the first port is the columnar wall segment.

[0018] Another technical solution adopted in this application is: a method for preparing frozen microspheres, which uses a frozen microsphere preparation device to selectively prepare the desired type of frozen microspheres. The frozen microsphere preparation device includes a dripping system, a driving system, and an insulated container. The dripping system can control the automatic dripping of reagent solution into the corresponding insulated container. The driving system drives the relative movement of the insulated container and the dripping system.

[0019] The preparation method includes:

[0020] Select a preset mode, and according to the selected preset mode, connect the drip system to a preset type of reagent solution;

[0021] The insulated tank and the dripping system are driven to move relative to each other at a preset speed, and the dripping system discharges the corresponding reagent solution at preset time intervals and preset quantities; wherein,

[0022] During each preset time interval, the insulation tank and the dripping system move relative to each other until the dripping pipe of the dripping system corresponds to the dripping inlet of the insulation tank.

[0023] According to one embodiment of this application, selecting a preset mode and connecting the droplet system to a preset type of reagent solution according to the selected preset mode includes: selecting to prepare the same type of frozen microspheres; the droplet tube is connected to a reagent supply device through a corresponding dispenser; and the reagent supply device supplies the same reagent solution.

[0024] According to one embodiment of this application, selecting a preset mode and connecting the droplet system to a preset type of reagent solution according to the selected preset mode includes: selecting to prepare different types of frozen microspheres; the droplet tube is connected to a reagent supply device through a corresponding dispenser; and the reagent supply device supplies a preset number of reagent solutions, wherein the number of types of reagent solutions is the same as the number of types of frozen microspheres.

[0025] According to one embodiment of this application, the step of driving the insulated tank and the dripping system to move relative to each other at a preset speed, and the dripping system discharging the corresponding reagent liquid at preset time intervals and preset quantities, includes: fixing the dripping system, and mounting the insulated tank on a working plate; driving the working plate to rotate continuously or intermittently around the same axis; and arranging the insulated tanks in an arc around the axis.

[0026] According to one embodiment of this application, before selecting the preset mode, the method further includes: adjusting and detecting that the frozen microsphere preparation device is in its initial position; detecting the coolant in each of the insulating tanks and adjusting it to a preset amount as needed; and calibrating the dropper so that it discharges the reagent liquid along the direction of gravity.

[0027] The beneficial effects of this application are as follows: This application uses multiple drip tubes to simultaneously discharge one or more different reagent solutions. A drive system drives the drip system and the insulating tank to move relative to each other. When the drip tubes align with the corresponding drip inlets of the insulating tank, the reagent solutions discharged independently by the drip tubes flow into the insulating tank from the drip inlets. Under the action of the coolant inside the insulating tank, the flowing reagent solutions are frozen, thus completing the automatic preparation of frozen microspheres. This method has low production costs, a simple structure, and is easy to operate. Furthermore, because multiple drip tubes can simultaneously discharge different reagent solutions, it enables the simultaneous preparation of one or more frozen microspheres, providing multifunctionality and improving production efficiency. Attached Figure Description

[0028] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort, wherein:

[0029] Figure 1 This is a schematic diagram of the structure of a multifunctional preparation device for frozen microspheres according to an embodiment of this application;

[0030] Figure 2 This is a schematic diagram of the structure of a multifunctional preparation device for frozen microspheres according to another embodiment of this application;

[0031] Figure 3 This is a schematic diagram of the structure of the multifunctional preparation device for frozen microspheres in one embodiment of this application, in which the heat insulation tank is installed in the mounting position;

[0032] Figure 4 This is a schematic diagram of the structure of the insulated tank in the multifunctional preparation device for frozen microspheres according to one embodiment of this application;

[0033] Figure 5 This is a schematic diagram of the structure of the insulated tank in the multifunctional preparation device for frozen microspheres according to another embodiment of this application;

[0034] Figure 6 This is a schematic diagram of the guide channel in a multifunctional preparation device for frozen microspheres according to an embodiment of this application;

[0035] Figure 7 This is a schematic diagram of the droplet system in a multifunctional preparation device for frozen microspheres according to an embodiment of this application;

[0036] Figure 8 This is a schematic flowchart of a method for preparing frozen microspheres according to an embodiment of this application.

[0037] Explanation of main structure and symbols:

[0038] 1. Drive system; 101. First drive component; 102. Second drive component; 103. Third drive component; 2. Insulated tank; 3. Drip system; 301. Drip tube; 302. Dispenser; 4. Working tray; 5. Working frame; 6. Mounting slot; 7. Mounting plate; 8. Fixing frame; 9. Drip inlet; 10. Sealing bottle; 11. Guide component; 111. Guide channel; 1111. Columnar wall section; 1112. Conical wall section; 112. Neck; 12. Mounting through hole; 13. Clamping arm; 14. Connecting hole; 15. First port; 16. Second port. Detailed Implementation

[0039] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0040] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0041] Please see Figures 1 to 7 This application provides a multifunctional preparation device for frozen microspheres. The device includes a drive system 1, a dripping system 3, and multiple insulated tanks 2.

[0042] Each insulated tank 2 contains a coolant and includes a drip inlet 9; the dripping system 3 includes at least two drip tubes 301, each drip tube 301 independently discharges reagent liquid according to a preset time interval and a preset metering, and the drip tube 301 can select the type of reagent liquid to discharge according to a preset mode; the drive system 1 drives the dripping system 3 and the insulated tank 2 to move relative to each drip tube 301 so that it is aligned with or offset from the drip inlet 9 of the corresponding insulated tank 2.

[0043] As needed, multiple drip tubes 301 can simultaneously discharge one or more different reagent solutions. Driven by the driving system 1, the drip system 3 and the insulating tank 2 move relative to each other. When a drip tube 301 aligns with the corresponding drip inlet 9 of the insulating tank 2, the reagent solution discharged from the drip tube 301 flows into the insulating tank 2 through the drip inlet 9. Under the action of the coolant inside the insulating tank 2, the flowing reagent solution is frozen, thus completing the automatic preparation of frozen microspheres. This method has low production costs, a simple structure, and is easy to operate. Because multiple drip tubes 301 can simultaneously discharge different reagent solutions, multiple types of frozen microspheres can be prepared simultaneously. Therefore, users can choose to prepare one or more types of frozen microspheres simultaneously as needed, offering multifunctionality and improving production efficiency.

[0044] Within a preset time interval for discharging reagent solution from each dropper 301, the dropper 301 and the corresponding dropper inlet 9 of the insulating tank 2 are aligned, thus avoiding errors from manual operation and the need to wait due to uncontrolled timing during manual operation. Furthermore, the dropper 301 in the dripping system 3 can be selected according to the number of frozen pellets to be prepared, and with the relative movement of multiple insulating tanks 2, the reagent solution discharged from the dropper 301 flows into the insulating tank 2 more quickly, improving production efficiency. It should be noted that when preparing the same type of frozen pellets, the same reagent solution is introduced into each dropper 301; when preparing different types of frozen pellets, different reagent solutions are introduced into each dropper 301, allowing the operator to select the appropriate solution based on the preparation requirements, further improving production efficiency.

[0045] To facilitate the setting of preset time intervals and preset dosages for each dropper 301, in one embodiment, the multifunctional preparation device for frozen microspheres also includes a human-machine interface (HMI) with preset modes displayed on it. The operator can set the corresponding preset time interval and preset dosage based on the characteristics of the reagent solution within the preset modes on the HMI, simplifying cumbersome operation steps. Within the preset time interval of each dropper 301, the corresponding insulating tank 2 always moves relative to it until it aligns with the droplet inlet 9. Preferably, there are multiple insulating tanks 2 corresponding to the dropper 301, and each insulating tank 2 moves sequentially until its droplet inlet 9 aligns with the dropper 301, and then shifts away. In this way, the reagent solution and coolant have sufficient cooling time during the time interval between the shift of the droplet inlet 9 of each insulating tank 2 and the next alignment with the dropper 301, eliminating the need for additional cooling time. Therefore, the insulating tanks 2 can be continuously driven, improving work efficiency.

[0046] Please see Figure 2 and Figure 7 In one embodiment, the dripping system 3 further includes at least two dispensers 302 and a reagent supply device. Each dispenser 302 is connected to a corresponding drip tube 301, and the dispenser 302 is connected to the corresponding reagent supply device according to a selected preset mode. Through the connection between the dispenser 302 and the reagent supply device, the reagent solution in the reagent supply device is dispensed by the dispenser 302 and flows to the drip tube 301, thereby flowing into the insulated tank 2. However, due to different production requirements, it may be necessary to prepare only the same type of frozen pellets, or it may be necessary to prepare multiple types of frozen pellets. Therefore, it is necessary to supply reagent solution separately to the reagent supply device, so that the reagent solution dispensed by the dispenser 302 is discharged independently, so as to facilitate the simultaneous preparation of different frozen pellets without interference.

[0047] If the same type of frozen microspheres are to be prepared, according to the preset mode, the corresponding reagent supply device connected to each dispenser 302 supplies the same reagent solution, and discharges it simultaneously through the corresponding dropper 301.

[0048] If different frozen pellets are prepared, according to the preset mode, each dispenser 302 is connected to a corresponding reagent supply device that supplies different or not completely identical reagent solutions, and these solutions are simultaneously discharged through the corresponding dropper 301.

[0049] To accelerate the dripping frequency and increase production efficiency, in one embodiment, the multifunctional preparation equipment for frozen microspheres further includes a work frame 5 and a work disk 4 that rotates relative to the work frame 5. The dripping system 3 is fixed to the work frame 5; the work disk 4 has several mounting slots 6, and each insulated tank 2 is mounted on a corresponding mounting slot 6; the drive system 1 includes a first drive component 101, which drives the work disk 4 to rotate continuously. These insulated tanks 2 can be divided into multiple groups as needed, with no limit on the number in each group, and each group of insulated tanks 2 corresponds to a dripping tube 301. Generally, one group of insulated tanks 2 is used to prepare the same type of frozen microspheres. The first drive component 101 drives each insulated tank 2 in each group to move sequentially within a preset time interval until it aligns with the dripping inlet 9 of the corresponding dripping tube 301, thereby allowing the reagent solution in the dripping tube 301 to drain into the insulated tank 2 of that group.

[0050] In actual operation, the working plate 4 is driven to rotate continuously by the first driving component 101. Since each insulation tank 2 is installed on the corresponding mounting position 6 of the working plate 4, the corresponding insulation tank 2 moves within a preset time interval. When the corresponding insulation tank 2 moves to the corresponding insulation tank 2 drip inlet 9, the drip pipe 301 independently discharges the reagent liquid according to the preset time interval and preset metering, so that the discharged reagent liquid flows from the insulation tank 2 drip inlet 9 into the corresponding insulation tank 2, which accelerates the dripping frequency and helps to improve production efficiency.

[0051] Specifically, such as Figure 2 As shown, the mounting slots 6 are arranged in an arc shape and are evenly distributed; the drip tubes 301 are also arranged in an arc shape, which facilitates the control of the movement of the insulated tank 2. The reagent liquid discharged from each pair of adjacent drip tubes 301 is of a different type.

[0052] In order to collect the frozen pellets flowing into the insulation tank 2, such as Figure 2 As shown, in one embodiment, please refer to Figure 4 and Figure 5 The multifunctional preparation equipment for frozen microspheres also includes a packaging bottle 10 installed in an insulated tank 2. Each packaging bottle 10 is connected to a corresponding insulated tank 2, and each insulated tank 2 is also equipped with a guide component 11.

[0053] For details, please refer to Figure 4 and Figure 5 The guide member 11 includes a guide channel 111 and a connecting hole 14 that communicates with the guide channel 111. The connecting hole 14 is located below the liquid surface of the coolant. The shape formed by any region of the connecting hole 14 is not equal to or includes the cross section passing through the center of the frozen sphere. The reagent solution of the frozen sphere enters the guide channel 111 through the first port 15 of the guide channel 111. The second port 16 of the guide channel 111 communicates with the packaging bottle 10.

[0054] In this embodiment, the guiding component 11 is provided with a guiding channel 111, a first port 15 for dripping reagent solution, a second port 16 for guiding frozen microspheres into the encapsulation bottle 10, and a connecting hole 14 for connecting coolant. During the preparation process, the first port 15 is the inlet of the guiding channel 111, and the second port 16 is the outlet of the guiding channel 111. The coolant (liquid nitrogen) in the insulated tank 2 fills the guiding channel 111 through the connecting hole 14. The coolant (liquid nitrogen) in the guiding channel 111 reacts with the reagent solution to form frozen microspheres. Then, under the guidance of gravity and the guiding channel 111, the frozen microspheres directly enter the encapsulation bottle 10 through the second port 16.

[0055] Furthermore, since the connecting hole 14 is located below the liquid surface of the coolant, the shape formed by any region of the connecting hole 14 is not equal to or includes the cross section passing through the center of the frozen ball. That is, the diameter of the connecting hole 14 is not greater than the outer diameter of the frozen ball. This allows the connecting hole 14 to communicate with the coolant in the Dewar flask, facilitating the entry of the coolant into the guide channel 111, while also preventing the frozen ball from leaking out through the connecting hole 14.

[0056] Please see Figure 3 and Figure 4 In one embodiment, each insulated tank 2 includes a mounting through hole 12, and each guide member 11 is installed within the mounting through hole 12. The equipment for preparing frozen microspheres also includes a mounting frame 8; the guide member 11 further includes a mounting plate 7 mounted on the mounting frame 8, with a first port 15 penetrating the mounting plate 7; the drive system 1 further includes a second drive member 102, which drives the mounting frame 8 to move, thereby causing the guide member 11 to slide into or detach from the mounting through hole 12.

[0057] Please see Figures 4 to 6In one embodiment, the mounting bracket 8 is fixedly provided with a clamping arm 13, which extends into the insulation tank 2, and the sealing bottle 10 is movably mounted on the clamping arm 13. The sealing bottle 10 includes a bottle mouth with a diameter larger than the diameter of the frozen pellets, and the guide member 11 includes a neck 112 that fits onto the bottle mouth. The drive system 1 further includes a third drive member 103, which is connected to the mounting plate 7 and drives the mounting plate 7 to move, thereby moving the neck 112 of the guide member 11 to engage or disengage from the bottle mouth.

[0058] In practical use, the third driving component 103 can be driven to guide the guide component 11 to pre-connect with the packaging bottle 10 before the frozen pellets are prepared. After the packaging is completed, the guide component 11 is still detached from the packaging bottle 10 by the third driving component 103, which also facilitates the subsequent processing of the packaging bottle 10. The whole process is done without human intervention, which can greatly reduce labor intensity and solve the problem of contamination of frozen pellets.

[0059] Specifically, the structure of the third driving component 103 may include a drive motor, a fixed bracket, a ball screw, a slider, and a guide rail. The drive motor drives the ball screw to rotate on the fixed bracket, thereby causing the slider to perform linear displacement on the guide rail. The slider is fixedly connected to the mounting plate 7, thereby causing the mounting plate 7 to move. It is understood that the above-described specific structure of the third driving component 103 is an optional embodiment for ease of understanding in this application. Other structures that can realize the specific functions of the third driving component 103 in this application can also be used as the third driving component 103 in this application, and will not be described in detail here.

[0060] Please see Figure 5 and Figure 6 In one embodiment, the centerline of the guide channel 111 is a straight line. The guide channel 111 includes at least one columnar wall segment 1111 and at least one conical wall segment 1112. The columnar wall segment 1111 and the conical wall segment 1112 are arranged alternately at intervals. Along the direction from the first port 15 to the second port 16, the slope of the conical wall segment 1112 increases sequentially, and the size of the guide channel 111 decreases. The portion of the guide channel 111 located at the first port 15 is the columnar wall segment.

[0061] Specifically, along the direction from the first port 15 to the second port 16, the columnar wall segment 1111 and the conical wall segment 1112 are alternately arranged, that is: along the direction from the first port 15 to the second port 16, first a conical wall segment 1112, then a columnar wall segment 1111, and then another conical wall segment 1112, see... Figure 6 .

[0062] Furthermore, the slope of the conical wall segment 1112 near the first port 15 is smaller than that of the conical wall segment 1112 near the second port 16; that is, the inclination slope of the conical wall segment 1112 near the second port 16 is greater, and the inclination normal of the conical wall segment 1112 near the second port 16 is closer to the center line of the guide channel 111. This facilitates the smooth flow of the frozen pellets into the encapsulation bottle 10.

[0063] It should be noted that as long as the guide channel 111 in the guide member 11 of this application meets the above-mentioned technical features regarding the conical wall section 1112, it can guide the frozen pellets to fall smoothly into the packaging bottle 10. As for the appearance and shape of the guide member 11, there are no special requirements.

[0064] Please see Figure 8 This application also provides a method for preparing frozen microspheres, which can selectively prepare the desired type of frozen microspheres using a frozen microsphere preparation device. The frozen microsphere preparation device includes a dripping system 3, a driving system 1, and an insulated tank 2. The dripping system 3 can control the automatic dripping of reagent liquid into the corresponding insulated tank 2. The driving system 1 drives the relative movement of the insulated tank 2 and the dripping system 3.

[0065] The method for preparing frozen microspheres includes the following steps:

[0066] S100. Select a preset mode, and according to the selected preset mode, make the drip system 3 connect to the preset reagent liquid type.

[0067] The preset modes include preset modes for producing one type of frozen pellet and preset modes for producing multiple types of frozen pellets; that is, whether to select to prepare the same type of frozen pellet or multiple types of frozen pellets. The drop system 3 is connected to a preset reagent solution of the same type as the type of frozen pellets to be prepared in the preset types.

[0068] Furthermore, in some embodiments, the speed of driving the insulated tank 2, the time interval and metering of the reagent liquid discharged by the dripping system 3 are preset in different preset modes, which makes it convenient for operators to select different preset modes for production according to the preparation needs.

[0069] S200, the insulated tank 2 and the dripping system 3 are driven to move relative to each other at a preset speed, and the dripping system 3 discharges the corresponding reagent liquid according to a preset time interval and a preset metering; wherein, in each preset time interval, the insulated tank 2 and the dripping system 3 move relative to each other until the dripping pipe 301 of the dripping system 3 corresponds to the dripping inlet 9 of the corresponding insulated tank 2.

[0070] Specifically, a corresponding preset mode is selected based on the type of frozen microspheres to be prepared. Then, according to the selected preset mode, the dripping system 3 is connected to a preset type of reagent solution. The number of reagent solution types is the same as the type of frozen microspheres to be prepared in the selected preset mode. Next, the adiabatic tank 2 and the dripping system 3 are driven to move relative to each other at a preset speed, ensuring that the adiabatic tank 2 corresponding to the dripping tube 301 is always aligned with the dripping inlet 9 of the adiabatic tank 2. When the dripping tube 301 is aligned with the dripping inlet 9 of the corresponding adiabatic tank 2, the dripping system 3 discharges the corresponding reagent solution according to a preset time interval and preset metering, allowing the reagent solution to flow into the adiabatic tank 2. When the dripping tube 301 is misaligned with the dripping inlet 9 of the corresponding adiabatic tank 2, the corresponding dripping system 3 stops dripping, allowing the corresponding reagent solution to drip into the corresponding adiabatic tank 2. Finally, the flowing reagent solution is frozen under the action of the coolant in the adiabatic tank 2, thus completing the automatic preparation of frozen microspheres. This method is simple in structure, convenient in operation, improves production efficiency, and has a better freezing effect. In addition, the aforementioned preset speed refers to the speed value of the relative rotation between the insulated tank 2 and the dripping pipe 301, which needs to be selected according to the type of frozen pellets being prepared.

[0071] In one embodiment, the step of selecting a preset mode and, based on the selected preset mode, connecting the droplet system 3 to a preset type of reagent solution includes the following steps:

[0072] Select the same type of frozen microspheres for preparation;

[0073] The dropper 301 is connected to a reagent supply device via a corresponding dispenser 302; and the reagent supply device supplies the same reagent solution.

[0074] In one embodiment, the step of selecting a preset mode and, based on the selected preset mode, connecting the droplet system 3 to a preset type of reagent solution includes the following steps:

[0075] Different types of frozen microspheres were prepared;

[0076] The dropper 301 is connected to a reagent supply device via a corresponding dispenser 302; and the reagent supply device supplies a variety of preset reagent solutions, wherein the number of types of reagent solutions is the same as the number of types of frozen pellets.

[0077] Specifically, for example, when preparing two different types of frozen microspheres, the reagent supply device supplies two reagent solutions according to a preset mode. Then, the two different types of reagent solutions are delivered to the corresponding dropper 301 through the corresponding dispenser 302. Then, driven by the drive system 1, the corresponding insulated tank 2 moves to the corresponding dropper 301, so that the drop inlet 9 of the corresponding insulated tank 2 is aligned with the corresponding dropper 301. Then, the dropper 301 that delivers different reagent solutions drips the reagent solution into the corresponding insulated tank 2 according to the preset time interval and discharge metering, thereby realizing the simultaneous preparation of different types of frozen microspheres.

[0078] In one embodiment, the step of driving the insulated tank 2 and the dripping system 3 to move relative to each other at a preset speed, and the dripping system 3 discharging the corresponding reagent liquid at preset time intervals and preset quantities, includes the following steps:

[0079] The dripping system 3 is fixed, and the insulated tank 2 is mounted on a working plate 4;

[0080] The working disk 4 is driven to rotate continuously or intermittently around the same axis;

[0081] The heat insulation tanks 2 are arranged in an arc around the axis.

[0082] In this embodiment, the dripping system 3 is fixed, and the insulation tank 2 is installed on a working plate 4 and arranged in an arc around the axis. Then, the working plate 4 is driven to rotate continuously or intermittently around the same axis, causing the insulation tank 2 installed on the working plate 4 to rotate accordingly. This makes the dripping pipe 301 of the dripping system 3 correspond to the dripping inlet 9 of the corresponding insulation tank 2, so that the dripping system 3 can discharge the corresponding reagent liquid according to the preset time interval and preset metering, so that the reagent liquid flows into the insulation tank 2.

[0083] In one embodiment, before selecting the preset mode, the following steps are also included:

[0084] Adjust and check that the frozen microsphere preparation equipment is in its initial position;

[0085] The coolant in each of the aforementioned insulation tanks 2 is detected and adjusted to a preset amount as needed;

[0086] The dropper 301 is calibrated so that it discharges the reagent solution along the direction of gravity.

[0087] In this embodiment, the initial position of the frozen microsphere preparation equipment is detected and adjusted. Then, the coolant in each insulation tank 2 is detected and adjusted to a preset amount according to the preparation requirements, so that there is enough coolant to cool the reagent liquid in the insulation tank 2, thereby forming frozen microspheres. Then, the drip tube 301 is calibrated so that the drip tube 301 discharges the reagent liquid along the direction of gravity, thereby allowing the reagent liquid to flow more accurately into the insulation tank 2 and avoiding leakage.

[0088] The terms "first," "second," and "third" in this application are for descriptive purposes only and should not be construed as indicating the number of technical features indicated. Therefore, a feature defined as "first," "second," or "third" may explicitly or implicitly include at least one of those features. All directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationships and movements between components in a specific orientation (as shown in the figures). If the specific orientation changes, the directional indications will change accordingly. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. A process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products, or devices.

[0089] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A multifunctional preparation device for frozen microspheres, characterized in that, It includes a drive system, a dripping system, and multiple insulated tanks; Each of the aforementioned insulated tanks contains a coolant and includes a drip inlet; The dripping system includes at least two drip tubes, each drip tube independently dispensing reagent liquid according to a preset time interval and a preset metering. The drip tube can select the type of reagent liquid to be dispensed according to a preset mode, and the type of reagent liquid is at least one. The drive system drives the dripping system and the insulation tank to move relative to each dripping tube so that it is aligned with or offset from the dripping inlet of the corresponding insulation tank. Each of the heat-insulating tanks is further provided with a movably connected guide component and a packaging bottle. Each guide component includes a guide channel and a connecting hole that penetrates the guide channel. The connecting hole is located below the liquid surface of the coolant. The first port of the guide channel is connected to the drip inlet, and the second port of the guide channel is connected to the corresponding packaging bottle.

2. The multifunctional preparation equipment according to claim 1, characterized in that, It also includes a human-computer interaction interface, on which the preset mode is displayed.

3. The multifunctional preparation equipment according to claim 1 or 2, characterized in that, The dripping system also includes at least two dispensers and a reagent supply device. Each dispenser is connected to a corresponding drip tube, and the dispenser is connected to the corresponding reagent supply device according to a selected preset mode.

4. The multifunctional preparation equipment according to claim 3, characterized in that, According to the preset mode, each of the dispensers is connected to a corresponding reagent supply device that supplies the same reagent solution, and the solutions are simultaneously discharged through the corresponding dropper; or Each of the dispensers is connected to a corresponding reagent supply device that supplies different or not exactly the same reagent solution, and the solutions are simultaneously discharged through the corresponding dropper.

5. The multifunctional preparation equipment according to claim 3, characterized in that, It also includes a work frame and a work disk that rotates relative to the work frame, wherein the dripping system is fixed on the work frame; The working plate is provided with a number of mounting slots, and each insulation tank is installed in the corresponding mounting slot; The driving system includes a first driving component, which drives the working disc to rotate continuously and drives the corresponding insulation tank to move to the corresponding insulation tank drip inlet within the preset time interval.

6. The multifunctional preparation equipment according to claim 5, characterized in that, The mounting slots are arranged in an arc shape and are evenly distributed; the drip tubes are also arranged in an arc shape.

7. The multifunctional preparation equipment according to claim 5, characterized in that, The shape formed by any region of the connecting hole is not equal to or includes the cross section passing through the center of the frozen sphere; The reagent solution of the frozen pellet enters the guide channel through the first port, and the frozen pellet enters the packaging bottle through the second port.

8. The multifunctional preparation equipment according to claim 7, characterized in that, Each of the aforementioned insulation tanks includes a mounting through hole, and each of the aforementioned guide members and the aforementioned encapsulation bottle is installed within the mounting through hole; The equipment for preparing frozen microspheres also includes a fixing frame; The guiding component also includes a mounting plate installed on the fixed frame, with the first port penetrating the mounting plate; The drive system further includes a second drive member, which drives the fixing frame to move so as to cause the guide member and the encapsulation bottle to slide into or out of the mounting through hole.

9. The multifunctional preparation equipment according to claim 8, characterized in that, The fixing frame is fixedly provided with a clamping arm, which extends into the corresponding mounting through hole; The encapsulation bottle includes a bottle mouth, the diameter of which is larger than the diameter of the frozen pellets, and the guide member includes a neck that is fitted onto the bottle mouth; The encapsulation bottle is movably mounted on the clamping arm; The drive system further includes a third drive component, which is connected to the mounting plate and drives the mounting plate to move so as to move the neck of the guide member to engage or disengage from the bottle neck.

10. The multifunctional preparation equipment according to claim 7, characterized in that, The centerline of the guide channel is a straight line, and the guide channel includes at least one columnar wall segment and at least one conical wall segment, with the columnar wall segment and the conical wall segment being arranged alternately at intervals. Along the direction from the first port to the second port, the slope of the conical wall segment increases sequentially, and the size of the guide channel decreases. The portion of the guide channel located at the first port is a columnar wall segment.

11. A method for preparing frozen microspheres, wherein a desired type of frozen microspheres can be selectively prepared using a multifunctional frozen microsphere preparation device as described in any one of claims 1-10, wherein the frozen microsphere preparation device includes a dripping system, a driving system, and an insulated tank, wherein, The dripping system can be controlled to automatically drip reagent solution into the corresponding insulated container; The driving system drives the relative movement of the insulated tank and the dripping system; characterized in that the preparation method includes: Select a preset mode, and according to the selected preset mode, connect the drip system to a preset type of reagent solution; The insulated tank and the dripping system are driven to move relative to each other at a preset speed, and the dripping system discharges the corresponding reagent solution at preset time intervals and preset quantities; wherein, During each preset time interval, the insulation tank and the dripping system move relative to each other until the dripping pipe of the dripping system corresponds to the dripping inlet of the insulation tank.

12. The preparation method according to claim 11, characterized in that, The selection of a preset mode, and the connection of the droplet system to a preset type of reagent solution according to the selected preset mode, includes: Select the same type of frozen microspheres for preparation; The dropper is connected to a reagent supply device via a corresponding dispenser; and the reagent supply device supplies the same reagent solution.

13. The preparation method according to claim 11, characterized in that, The selection of a preset mode, and the connection of the droplet system to a preset type of reagent solution according to the selected preset mode, includes: Different types of frozen microspheres were prepared; The dropper is connected to a reagent supply device via a corresponding dispenser; and the reagent supply device supplies a variety of preset reagent solutions, wherein the number of types of reagent solutions is the same as the number of types of frozen pellets.

14. The preparation method according to any one of claims 11-13, characterized in that, The step of driving the insulated tank and the dripping system to move relative to each other at a preset speed, and the dripping system discharging the corresponding reagent solution at preset time intervals and preset quantities, includes: The dripping system is fixed, and the insulated tank is mounted on a working plate; The working disk is driven to rotate continuously or intermittently around the same axis; The insulated tanks are arranged in an arc around the axis.

15. The preparation method according to claim 14, characterized in that, Before selecting the preset mode, the following is also included: Adjust and check that the frozen microsphere preparation equipment is in its initial position; The coolant in each of the aforementioned insulation tanks is detected and adjusted to a preset amount as needed; Calibrate the dropper so that it discharges the reagent solution along the direction of gravity.

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