Cryosphere generation components and preparation equipment

Abstract

The present application discloses a generation component and preparation equipment for cryospheres. The generation component includes an insulating tank and a packaging bottle, the insulating tank is filled with a coolant, and the packaging bottle is accommodated in the insulating tank; the generation component of the cryospheres also includes a guide member, the guide member includes a guide channel and a connecting hole that penetrates the guide channel, the connecting hole is located below the liquid level of the coolant, and the shape formed by any range area of ​​the connecting hole is not equal to or includes the cross-section passing through the center of the cryosphere; the guide member is installed in the insulating tank, and the reagent liquid of the cryosphere enters the guide channel through the first port, and the second port of the guide channel is connected to the packaging bottle. The cryosphere generation component of the present application is provided with a guide member, which can automatically deliver the prepared cryospheres into the packaging bottle. The delivery process is all achieved by the generation component, without manual intervention, and the sterility and pollution-free nature of the entire transportation environment is guaranteed, which can solve the contamination problem of the cryospheres during transportation after preparation.

Description

Technical Field

[0001] The present application relates to the technical field of frozen pellet preparation equipment, and in particular to a frozen pellet generation component and preparation equipment. Background Art

[0002] Lyophilized pellets, also known as freeze-dried beads or liquid nitrogen dot pellets, involve dropping reagents / drug solutions into liquid nitrogen via a specialized precision micropump. These pellets are then rapidly frozen into uniform, regular solid spheres at extremely low temperatures for a short period of time. These pellets are then collected and stored frozen in a freeze-drying facility. Lyophilized bead technology maximizes the activity of enzymes and proteins, and its loose, reticular structure allows for rapid reconstitution. Lyophilized bead technology can transform unstable chemical reagents into high-quality, stable, and quantitative lyophilized pellets, and is therefore used in the storage and transportation of pharmaceuticals and the preservation of cosmetics.

[0003] During the freeze-dried pellet production process, reagents / drug solutions must be frozen into small pellets, then manually packaged and fed into a freeze-drying machine for further freeze-drying before becoming the final product. However, after extensive research, the inventors of this application discovered that, as an intermediate product in the freeze-dried pellet production process, the pellets must be manually poured into packaging bottles after being prepared in an insulated cup. This process often results in contamination, hindering the preservation of cosmetics or pharmaceuticals. Therefore, finding a solution to the contamination-free delivery of prepared pellets into packaging bottles is of particular importance and urgency. Summary of the Invention

[0004] The present application provides a generating assembly and a preparation device for cryospheres, which are intended to solve the pollution problem caused by manually delivering cryospheres into packaging bottles mentioned in the background art.

[0005] In order to solve the above technical problems, a technical solution adopted in the present application is: a generating assembly for freezing pellets, comprising an insulating tank and a packaging bottle, wherein the insulating tank is filled with a coolant and the packaging bottle is accommodated in the insulating tank;

[0006] The frozen ball generating assembly further includes a guide member, the guide member including a guide channel and a communication hole penetrating the guide channel, the communication hole being located below the liquid level of the coolant, and the shape formed by any range of the communication hole does not equal or include a cross section passing through the center of the frozen ball;

[0007] The guide member is installed in the thermal insulation tank, the reagent solution of the freezing pellets enters the guide channel through the first port of the guide channel, and the second port of the guide channel is communicated with the packaging bottle.

[0008] According to one embodiment of the present application, a fixing bracket is further included, the insulated tank includes a mounting hole, the guide member is installed on the fixing bracket, and the fixing bracket can be operated to drive the guide member to slide to be installed in the mounting hole or detach from the mounting hole.

[0009] According to one embodiment of the present application, the fixing bracket is fixedly mounted on the guide member and is provided with a flange, and the flange is mounted against the outer wall of the insulation tank.

[0010] According to one embodiment of the present application, a through hole is provided on the fixing frame; a flange is provided on the guiding member, the through hole is slidably sleeved on the guiding member, and the flange is mounted on the top surface of the fixing frame facing away from the insulating tank.

[0011] According to one embodiment of the present application, a clamping arm is further provided on the fixing frame, and the end of the clamping arm extends into the insulating tank to clamp the packaging bottle.

[0012] According to one embodiment of the present application, a support platform is fixed to the end of the clamping arm, and the packaging bottle is supported on the support platform.

[0013] According to one embodiment of the present application, it also includes a limit plate movably mounted on the clamp arm, the limit plate is spaced apart from the support platform, a limit hole is provided on the limit plate, and the limit hole is sleeved on the outer wall of the packaging bottle.

[0014] According to one embodiment of the present application, a bayonet is provided on the edge of the limiting plate, and the bayonet is detachably buckled onto the clamping arm.

[0015] According to an embodiment of the present application, the fixing frame includes a first fixing plate, the through hole is provided on the first fixing plate, and the flange is abutted on the first fixing plate;

[0016] The frozen ball generating assembly further includes a first driving member connected to the first fixing plate, and the first driving member drives the first fixing plate to move, thereby driving the guide member to move.

[0017] According to one embodiment of the present application, a second driving member is further included, wherein the second driving member is connected to the guide member, and the second driving member drives the guide member to slide along the through hole and the mounting through hole to be connected to or separated from the packaging bottle.

[0018] According to one embodiment of the present application, the packaging bottle includes a bottle mouth, and the diameter of the bottle mouth is larger than the diameter of the frozen ball;

[0019] The guiding member includes a neck portion sleeved on the bottle mouth and a body portion arranged adjacent to the neck portion, and the neck portion is in clearance fit with the bottle mouth;

[0020] The first port passes through a portion of the guide member opposite to the neck;

[0021] The second port extends through the neck.

[0022] According to one embodiment of the present application, the center line of the guide channel is a straight line, the guide channel is funnel-shaped, and the internal size of the guide channel decreases along the direction from the first port to the second port.

[0023] According to one embodiment of the present application, the guide channel includes at least one cylindrical wall segment and at least one conical wall segment, and the cylindrical wall segment and the conical wall segment are alternately arranged;

[0024] Along the direction from the first port to the second port, the slope of the tapered wall segment increases sequentially, and the size of the guide channel decreases;

[0025] The portion of the guide channel located at the first port is a columnar wall segment.

[0026] According to one embodiment of the present application, the communicating hole is provided at a position of the body that is 1 / 5 to 1 / 3 of the depth of the guide channel away from the neck.

[0027] According to one embodiment of the present application, a bottom plate is provided at the first port, and at least one isolation plate is fixed on the bottom plate, each isolation plate is located in the guide channel, and the isolation plate divides the guide channel into a plurality of sub-channels;

[0028] The length of each of the isolation plates is smaller than the depth of the guide channel;

[0029] The guiding member includes a plurality of dripping inlets communicated with the second port, and the dripping inlets are respectively communicated with the corresponding sub-channels.

[0030] To solve the above technical problems, the present application also adopts a technical solution: a device for preparing frozen pellets, including a dropper and a frozen pellet generation component as described above, wherein the reagent liquid output by the dropper enters the guide channel through the first port.

[0031] The beneficial effects of the present application are as follows: the frozen ball generating assembly of the present application is designed with a guiding member, through which the prepared frozen balls can be automatically delivered into the packaging bottle. The delivery process is all realized by the generating assembly, without human intervention, while also ensuring the sterility and pollution-free nature of the entire delivery environment, which can perfectly solve the pollution problem in the prior art during the delivery process after the frozen balls are prepared. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present application. Those skilled in the art can also derive other drawings based on these drawings without inventive work, among which:

[0033] Figure 1 is a schematic diagram of the three-dimensional structure of the fixing frame and the guide member in the embodiment of the present application;

[0034] Figure 2 This is a schematic diagram of the structure of the frozen pellet preparation device in the embodiment of the present application;

[0035] Figure 3 yes Figure 2 A side structural diagram of

[0036] Figure 4 yes Figure 1 Schematic diagram of the structure viewed from above;

[0037] Figure 5 yes Figure 4 A cross-sectional structural diagram;

[0038] Figure 6 Schematic diagram of the structure of the frozen pellet preparation device including the insulated tank in the embodiment of the present application;

[0039] Figure 7 This is a schematic diagram of the structure of the frozen pellet preparation device in the embodiment of the present application without the insulation tank.

[0040] Description of main structures and symbols:

[0041] 1. Insulation tank; 2. Packaging bottle; 3. Guide member; 4. Guide channel; 5. Connecting hole; 6. First port; 7. Second port; 8. Fixing frame; 81. First fixing plate; 82. Guide column; 83. Second fixing plate; 9. Limiting hole; 10. Bottom plate; 11. Through hole; 12. Clamping arm; 13. Support platform; 14. Limiting plate; 15. Mounting plate; 16. Dropper; 17. First driving member; 18. Second driving member; 19. Neck; 20. Body; 21. Columnar wall segment; 22. Conical wall segment; 23. Isolation plate; 24. Sub-channel; 25. Working disk. DETAILED DESCRIPTION

[0042] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0043] References herein to "embodiments" mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0044] See also Figures 1 to 7 The present application discloses a freezing ball generation component, comprising an insulating tank 1 and a packaging bottle 2, wherein the insulating tank 1 is filled with a coolant, and the packaging bottle 2 is accommodated in the insulating tank 1; the freezing ball generation component also includes a guide member 3, the guide member 3 includes a guide channel 4 and a connecting hole 5 that passes through the guide channel 4, the connecting hole 5 is located below the liquid level of the coolant, and the shape formed by any range area of ​​the connecting hole 5 is not equal to or includes a cross-section passing through the center of the freezing ball; the guide member 3 is installed in the insulating tank 1, and the reagent liquid of the freezing ball enters the guide channel 4 through the first port 6 of the guide channel 4, and the second port 7 of the guide channel 4 is connected to the packaging bottle 2.

[0045] Based on how to solve the technical problem of pollution-free transportation of frozen balls after preparation, the frozen ball generating assembly of the present application includes a guiding member 3, wherein the guiding member 3 is provided with a guiding channel 4, a first port 6 for dripping a reagent solution, a second port 7 for guiding the frozen balls into the packaging bottle 2, and a connecting hole 5 for connecting the coolant. During the preparation process, the coolant (liquid nitrogen) in the guiding channel 4 reacts with the reagent solution to form frozen balls, and then the frozen balls directly enter the packaging bottle 2 through the second port 7 under the guidance of gravity and the guiding channel 4; further, the guiding member 3 is provided with a guiding channel 4, a first port 6 for dripping a reagent solution, a second port 7 for guiding the frozen balls into the packaging bottle 2, and a connecting hole 5 for connecting the coolant. The channel 4 is provided with a connecting hole 5 which is connected with the guide channel 4. The connecting hole 5 is located below the liquid surface of the coolant. The shape formed by any range area of ​​the connecting hole 5 is not equal to or includes the cross section passing through the center of the frozen ball, that is, the aperture of the connecting hole 5 is not larger than the outer diameter of the frozen ball. Its purpose is to be able to communicate with the coolant in the Dewar flask so that the coolant can enter the guide channel 4, and at the same time it can also limit the frozen ball from leaking out through the connecting hole 5. Furthermore, the first port 6 is the inlet of the guide member 3, and the second port 7 is the outlet of the guide member 3.

[0046] In this embodiment, the frozen ball generating assembly of the present application also includes a fixing frame 8, the insulating tank 1 includes a mounting through hole, the guide member 3 is installed on the fixing frame 8, and the fixing frame 8 can be operated to drive the guide member 3 to slide to be installed in the mounting through hole or to be detached from the mounting through hole, and the guide member 3 is adjusted to enter or detach from the insulating tank through the fixing frame 8.

[0047] Furthermore, in some embodiments, the fixing frame 8 is fixedly mounted on the guide member 3 and is provided with a flange, and the flange is mounted against the outer wall of the insulation tank 1 .

[0048] Further, in some embodiments, see Figure 1 and Figure 5 The fixing frame 8 is a frame structure comprising a first fixing plate 81, a second fixing plate 83, and a guide post 82. The guide post 82 is disposed between the first and second fixing plates 81, 83, and the first fixing plate 81 can slide on the guide post 82. The first fixing plate 81 is provided with a through hole 11. The guide member 3 is provided with a flange, which slides over the through hole 11. The flange is mounted on the top surface of the first fixing plate 81 facing away from the insulated tank 1. This design is intended to securely mount the guide member 3 on the first fixing plate 81, allowing the position of the guide member 3 within the insulated tank 1 to be adjusted by driving the first fixing plate 81.

[0049] See also Figure 5 , Figure 5 for Figure 4 The cross-sectional structural diagram in the AA direction of the embodiment specifically shows the internal structure of the fixing frame 8 and the guide member 3. It can be understood that in this embodiment, the fixing frame 8 is further provided with a clamping arm 12, and the end of the clamping arm 12 extends into the insulated tank 1 to clamp the packaging bottle 2. The number of the clamping arms 12 is not less than 2, and the clamping arms 12 are distributed in a circular manner on the fixing frame 8; further, a support platform 13 is fixed to the end of the clamping arm 12, and the packaging bottle 2 is supported on the support platform 13; further, it also includes a support 13 movably mounted on the clamping arm 12. A limiting plate 14 is provided, and the limiting plate 14 is spaced apart from the support platform 13. A limiting hole 9 is provided on the limiting plate 14, and the limiting hole 9 is sleeved on the outer wall of the packaging bottle 2. The packaging bottle 2 can be fixed by the support platform 13 and the limiting plate 14; further, a bayonet is provided on the edge of the limiting plate 14, and the bayonet is detachably snapped onto the clamping arm 12. The bayonet is designed to be snapped onto the clamping arm 12, maintaining the distance between the limiting plate 14 and the support platform 13, which can better fix the packaging bottle 2.

[0050] See also Figure 2 , Figure 2 This is a structural diagram of the frozen ball preparation equipment where the generation component of the present application is located, which includes a working disk 25, and the fixed frame 8 is arranged on the work station on the working disk 25, and the dropper 16 drips liquid to the guide channel 4 on each work station one by one in a rotating manner. It can be understood that in this embodiment, the frozen ball generation component also includes a first driving member 17, and the first driving member 17 is connected to the first fixed plate 81. The first driving member 17 drives the first fixed plate 81 to move, thereby driving the guide member 3 and the clamping arm 12 to move, and then the packaging bottle 2 moves together under the drive of the clamping arm 12, that is, the first driving member 17 is used to drive the guide member 3 and the packaging bottle 2 to move together, close to or away from the insulated tank 1. During specific use, the first driving member 17 can be driven to drive the guide member 3 and the packaging bottle 2 to enter the insulating tank 1 set on the fixed frame 8 in advance before the preparation of the frozen balls is completed. After the packaging is completed, the first driving member 17 is still used to separate the guide member 3 and the packaging bottle 2 from the insulating tank 1.

[0051] More specifically, the specific structure of the first driving member 17 may include a driving motor, a fixed bracket, a ball screw, a slider, and a guide rail. The driving motor drives the ball screw to rotate on the fixed bracket, thereby driving the slider to perform linear displacement on the guide rail. The slider is fixedly connected to the first fixed plate 81, thereby driving the displacement of the first fixed plate 81. It can be understood that the specific structure of the first driving member 17 described above is an optional embodiment for ease of understanding of this application. Other structures that can achieve the specific functions of the first driving member 17 of this application can also serve as the first driving member 17 of this application, and will not be described in detail here.

[0052] See also Figure 2 In this embodiment, a second driving member 18 is further included. The second driving member 18 is connected to the guide member 3 and drives the guide member 3 to slide along the through hole 11 and the mounting through hole to connect with or separate from the packaging bottle 2. More specifically, Figure 5As shown, a mounting plate 15 is provided at the first port 6 of the guide member 3. The mounting plate 15 is disposed at the upper end of the first fixing plate 81. A second driving member 18 is fixedly connected to the mounting plate 15. The second driving member 18 drives the mounting plate 15, thereby driving the guide member 3 away from the packaging bottle 2. In actual use, the second driving member 18 can be driven to pre-dock the guide member 3 with the packaging bottle 2 before the preparation of the frozen pellets is completed. After the packaging is completed, the second driving member 18 can still be used to detach the guide member 3 from the packaging bottle 2. This also facilitates subsequent processing of the packaging bottle 2. The entire process requires no human intervention, which can greatly reduce labor intensity and solve the problem of frozen pellet contamination.

[0053] More specifically, the specific structure of the second driving member 18 may include a driving motor, a fixed bracket, a ball screw, a slider, and a guide rail. The driving motor drives the ball screw to rotate on the fixed bracket, thereby driving the slider to perform linear displacement on the guide rail. The slider is fixedly connected to the mounting plate 15, thereby driving the displacement of the mounting plate 15. It will be understood that the specific structure of the second driving member 18 described above is an optional embodiment for ease of understanding of this application. Other structures that can achieve the specific functions of the second driving member 18 of this application can also serve as the second driving member 18 of this application, and will not be described in detail here.

[0054] It can be understood that the basic working process of the cryosphere generating component of the present application is summarized as follows: the dropper 16 drips the reagent liquid for preparing cryospheres through the first port 6 of the guide member 3, and the reagent liquid forms cryospheres in the process of reacting with the coolant (liquid nitrogen). After the cryospheres are formed, they fall into the neck 19 of the guide member 3 under the guidance of gravity, that is, the columnar wall section 21 and the conical wall section 22 of the guide channel 4, and enter the packaging bottle 2 through the second port 7. When the packaging bottle 2 collects a sufficient number of cryospheres, the first driving member 17 drives the guide member 3 and the packaging bottle 2 to leave the insulated tank 1 together, and further the second driving member 18 drives the guide member 3 away from the packaging bottle 2, so that the packaging bottle 2 can be taken out for half-capping and then sent to the freeze-drying equipment for freeze-drying. After freeze-drying, the packaged freeze-dried balls can be directly obtained, eliminating the problem of difficulty in packaging freeze-dried balls in traditional freeze-dried ball preparation technology, or the need for professional and expensive packaging equipment.

[0055] See also Figure 5According to one embodiment of the present application, the packaging bottle 2 includes a bottle mouth, and the guide member 3 includes a neck 19 that is sleeved on the bottle mouth and a body 20 disposed adjacent to the neck 19. The neck 19 and the bottle mouth are clearance-matched, which, on the one hand, allows the interior of the packaging bottle 2 to be simultaneously filled with coolant (liquid nitrogen) and, on the other hand, facilitates assembly and disassembly. The first port 6 penetrates the portion of the guide member 3 opposite the neck 19, and the second port 7 penetrates the neck 19. Furthermore, the centerline of the guide channel 4 is a straight line, and the guide channel 4 is funnel-shaped. The internal dimensions of the guide channel 4 decrease along the direction from the first port 6 to the second port 7. The dimension here can refer to the inner diameter of a circular channel or the width of a square channel, and the final dimension gradually decreases to ensure that the frozen pellets fall accurately into the packaging bottle 2.

[0056] It is worth mentioning that, in the guide member 3 of the present application, as long as the guide channel 4 can guide the frozen pellets to fall smoothly into the collection bottle, there are no special requirements for the appearance and shape of the guide member 3. However, in order to avoid the problem of large space occupied due to the bulky appearance of the guide member 3, in some embodiments, in order to save space, the guide channel 4 includes at least one columnar wall segment 21 and at least one conical wall segment 22, and the columnar wall segment 21 and the conical wall segment 22 are staggered at intervals, that is, the bordering end of each columnar wall segment 21 is the conical wall segment 22, and the portion of the guide channel 4 located at the first port 6 is the columnar wall segment 21, which prevents the dripped reagent liquid or the frozen pellets initially formed by the reagent liquid from hanging or resting on the wall of the guide channel 4; at the same time, along the direction from the first port 6 to the second port 7, the slope of the conical wall segment 22 increases successively, such as Figure 5 As shown in the figure, the slope of the conical wall section 22 near the neck 19 is significantly greater than the slope of the conical wall section 22 above the connecting hole 5, and the size of the guide channel 4 is reduced, so as to allow the frozen balls to fall smoothly into the packaging bottle 2 after preparation.

[0057] Furthermore, the communicating hole 5 is arranged at a position of the body 20 at a distance of 1 / 5 to 1 / 3 of the depth of the guide channel 4 from the neck 19, so that the communicating hole 5 is always located below the liquid surface of the coolant. On the one hand, it can ensure that the reagent liquid and the coolant have sufficient contact time, and on the other hand, it can also ensure the liquid nitrogen environment inside the guide channel 4 and the packaging bottle 2.

[0058] Since the reagent liquid floats on the surface of liquid nitrogen during the time from when it drips into the guide channel 4 to when it forms frozen balls and sinks into the second port 7, a large number of reagent droplets or frozen ball embryos gather at the columnar wall section 21 near the first port 6 of the guide channel 4, and are easily adhered to each other, thus affecting the quality of the frozen balls. Therefore, please refer to Figure 5 In this embodiment, the first port is provided with a base plate 10, which covers the guide channel 4. At least one isolation plate 23 is also fixed to the base plate 10. Each isolation plate 23 is located within the guide channel 4 and divides the guide channel 4 into several sub-channels 24 to prevent large amounts of reagent droplets from adhering to the frozen pellet precursors, thereby affecting the quality of the frozen pellets. The base plate 10 has a circular hole corresponding to each sub-channel 24, through which the reagent liquid from the dropper 16 enters the guide channel 4. The length of each isolation plate 23 is less than the depth of the guide channel 4.

[0059] The guide member 3 includes a plurality of dripping inlets connected to the second port 7, and the dripping inlets are respectively connected to the corresponding sub-channels 24. It is worth noting that the second port 7 always has only one outlet, and the plurality of dripping inlets are ultimately connected to the second port 7.

[0060] The present application also discloses a cryosphere preparation device, comprising the cryosphere generating assembly as described above, and a dropper 16, wherein the reagent solution output by the dropper 16 enters the guide channel 4 through the first port 6. Specifically, please refer to Figures 2 to 3 、 Figures 6 to 7 , Figure 2 The structure shown is a schematic diagram of the planar structure of the cryosphere preparation device where the cryosphere generation component of the present application is located. Figure 3 for Figure 2 A side view schematic diagram of the structure shown, Figure 6 The structure shown is a schematic diagram of the three-dimensional structure of the cryosphere preparation device where the cryosphere generation component of the present application is located. Figure 7 The structure shown is a schematic diagram of the three-dimensional structure of the frozen pellet preparation equipment where the frozen pellet generating assembly of the present application is located after removing the insulating tank 1, which includes a working disk 25, and the fixed frame 8 is mounted on the working disk 25. The dropper 16 drips liquid one by one on the guide channel 4 on the fixed frame 8 in a rotating manner.

[0061] The terms "first", "second" and "third" in this application are only used for descriptive purposes and should not be understood as indicating the number of the indicated technical features. Thus, the features defined as "first", "second" and "third" can explicitly or implicitly include at least one of these features. In the embodiments of the present application, all directional indications (such as up, down, left, right, front, back ...) are only used to explain the relative positional relationship, movement, etc. between the various components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication also changes accordingly. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally also includes steps or units that are not listed, or optionally also includes other steps or units inherent to these processes, methods, products or devices.

[0062] The above description is merely an embodiment of the present application and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A frozen pellet production assembly comprising an insulating tank and a packaging bottle, wherein the insulating tank is filled with a coolant, characterized in that: The packaging bottle is accommodated in the insulation tank; The frozen ball generating assembly further includes a guide member, the guide member including a guide channel and a communication hole penetrating the guide channel, the communication hole being located below the liquid level of the coolant, and the shape formed by any range of the communication hole does not equal or include a cross section passing through the center of the frozen ball; The guide member is installed in the thermal insulation tank, the reagent solution of the freezing pellets enters the guide channel through the first port of the guide channel, and the second port of the guide channel is communicated with the packaging bottle.

2. The frozen pellet production assembly according to claim 1, characterized in that It also includes a fixing frame, the insulation tank includes a mounting through hole, the guide member is installed on the fixing frame, and the fixing frame can be operated to drive the guide member to slide to be installed in the mounting through hole or to be detached from the mounting through hole.

3. The frozen pellet production assembly according to claim 2, characterized in that: The fixing frame is fixedly arranged on the guide member and is provided with a flange, and the flange is mounted against the outer wall of the insulation tank.

4. The frozen pellet production assembly according to claim 2, characterized in that: The fixing frame is provided with a through hole; the guiding member is provided with a flange, the through hole is slidably sleeved on the guiding member, and the flange is mounted on the top surface of the fixing frame facing away from the insulation tank.

5. The frozen pellet production assembly according to claim 3 or 4, characterized in that: The fixing frame is further provided with a clamping arm, and the end of the clamping arm extends into the insulation tank to clamp the packaging bottle.

6. The cryosphere generating assembly according to claim 5, characterized in that: A support platform is fixed to the end of the clamping arm, and the packaging bottle is supported on the support platform.

7. The cryosphere generating assembly according to claim 6, characterized in that: It also includes a limiting plate movably mounted on the clamping arm, the limiting plate and the supporting platform are spaced apart, a limiting hole is provided on the limiting plate, and the limiting hole is sleeved on the outer wall of the packaging bottle.

8. The cryosphere generating assembly according to claim 7, characterized in that: A bayonet is provided on the edge of the limiting plate, and the bayonet is detachably buckled on the clamping arm.

9. The cryosphere generating assembly according to claim 4, characterized in that: The fixing frame includes a first fixing plate, the through hole is provided on the first fixing plate, and the flange is abutted against the first fixing plate; The frozen ball generating assembly further includes a first driving member connected to the first fixing plate, and the first driving member drives the first fixing plate to move, thereby driving the guide member to move.

10. The cryosphere generating assembly according to claim 9, characterized in that: The invention further comprises a second driving member connected to the guide member, and the second driving member drives the guide member to slide along the through hole and the mounting through hole to be connected with or separated from the packaging bottle.

11. The frozen pellet production assembly according to any one of claims 1-4, 9-10, characterized in that: The packaging bottle comprises a bottle mouth, the diameter of which is larger than the diameter of the frozen pellets; The guiding member includes a neck portion sleeved on the bottle mouth and a body portion arranged adjacent to the neck portion, and the neck portion is in clearance fit with the bottle mouth; The first port passes through a portion of the guide member opposite to the neck; The second port extends through the neck.

12. The cryosphere generating assembly according to claim 11, characterized in that The center line of the guide channel is a straight line, and the guide channel is funnel-shaped. An inner dimension of the guide channel decreases along a direction from the first port to the second port.

13. The cryosphere generating assembly according to claim 12, characterized in that: The guide channel includes at least one cylindrical wall segment and at least one conical wall segment, and the cylindrical wall segment and the conical wall segment are arranged alternately; Along the direction from the first port to the second port, the slope of the tapered wall segment increases sequentially, and the size of the guide channel decreases; The portion of the guide channel located at the first port is a columnar wall segment.

14. The cryosphere generating assembly according to claim 11, characterized in that The communicating hole is arranged at a position on the body that is 1 / 5 to 1 / 3 of the depth of the guiding channel away from the neck.

15. The cryosphere generating assembly according to claim 11, characterized in that A bottom plate is provided at the first port, and at least one isolation plate is fixed on the bottom plate, each isolation plate is located in the guide channel, and the isolation plate divides the guide channel into a plurality of sub-channels; The length of each of the isolation plates is smaller than the depth of the guide channel; The guiding member includes a plurality of dripping inlets communicated with the second port, and the dripping inlets are respectively communicated with the corresponding sub-channels.

16. A device for preparing frozen pellets, comprising a dropper, characterized in that: The device comprises a frozen ball generating assembly as described in any one of claims 1 to 15, wherein the reagent liquid output by the dropper enters the guiding channel through the first port.

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