Valve clamping device and valve clamping system

Abstract

The application relates to a valve clamping device and a valve clamping system. The valve clamping device comprises a center seat, a locking piece, a transmission piece and a plurality of support arms; the support arms are arranged around the center seat and comprise a large arm and a small arm which are hingedly connected, the large arm is hingedly connected with the center seat through a first rotating shaft, and the small arm is connected with the transmission piece through a second rotating shaft; the locking piece is arranged in the center seat and has a first mode and a second mode, when the locking piece is in the first mode, the first rotating shaft is locked, and when the locking piece is in the second mode, the locking on the first rotating shaft is released; wherein when the locking piece releases the locking on the first rotating shaft, the first rotating shaft can move along the axial direction of the center seat to open or close the clamping piece. The valve clamping device can be firmly locked through the locking piece after the valve clamping device is sent to the lesion position and folded, the number of parts of the valve clamping device is reduced, and the assembly difficulty of the valve clamping device is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a valve clamping device and a valve clamping system. BACKGROUND

[0002] The mitral valve is an important valve of the heart, located between the left atrium and the right atrium. Blood is pumped from the left atrium into the left ventricle, and when the left ventricle contracts to pump blood into the body, the mitral valve closes to prevent blood from being pumped back into the left atrium. If the mitral valve becomes diseased and cannot close completely, it will cause blood to flow back into the left atrium when the left atrium contracts, i.e. mitral regurgitation. Mitral regurgitation can significantly reduce the pumping efficiency of the heart, thereby putting the patient at risk of severe, progressive heart failure.

[0003] Mitral valve plasty and artificial valve replacement are the most effective methods for treating mitral insufficiency, but because the surgery requires extracorporeal circulation technology support, it causes more trauma to the human body, and has a high rate of complications and mortality for elderly patients and patients with many comorbidities.

[0004] In recent years, with the breakthrough progress of valve interventional therapy technology, mitral regurgitation interventional therapy devices have become one of the key directions of cardiovascular device research and development at home and abroad. Mitral valve clipping as the mainstream interventional therapy method, through the apex of the heart, an implantable clamping device is sent to the mitral valve annulus, the free edges of the anterior and posterior leaflets are clamped and fixed, so that the leaflets are well coapted at the end of systole, reducing regurgitation.

[0005] Among them, when the mitral valve clamping device is sent to the lesion site and folded, the locking structure of the device can be used for locking. However, the locking structure of the existing mitral valve clamping device not only has poor locking reliability, but also has a complex structure, many components and high processing difficulty. SUMMARY

[0006] Therefore, it is necessary to provide a valve clamping device and a valve clamping system to solve the problems of poor locking reliability and many components of the locking structure of the existing mitral valve clamping device.

[0007] A valve clamping device, comprising: a center seat, a locking member, a transmission member, and a plurality of support arms;

[0008] The support arms are arranged around the center seat and include a large arm and a small arm connected by a hinge, the large arm is connected to the center seat by a first pivot, and the small arm is connected to the transmission member by a second pivot;

[0009] The locking member is arranged in the central seat and has a first shape and a second shape, when the locking member is in the first shape, the first rotating shaft is locked, when the locking member is in the second shape, the first rotating shaft is unlocked.

[0010] When the locking member unlocks the first rotating shaft, the first rotating shaft can move along the axial direction of the central seat to open or close the support arm.

[0011] In one embodiment, the locking member is made of shape memory material, and the locking member is in the first shape without external force.

[0012] In one embodiment, the locking member is provided with a locking hole for the first rotating shaft to pass through, when the locking member is in the first shape, the locking member clamps the first rotating shaft in the locking hole through frictional contact, when the locking member is in the second shape, the locking member releases the first rotating shaft.

[0013] In one embodiment, the locking member is arranged along the axial direction of the central seat, and the deformation direction of the locking member is parallel to the axial direction of the central seat.

[0014] In one embodiment, the locking member has a connecting region and a locking region, the connecting region is connected with the central seat, the locking region is curved, and the shape of the locking region can be switched between the first shape and the second shape, and the locking hole is arranged in the locking region.

[0015] In one embodiment, the locking member includes a first locking arm and a second locking arm connected with each other, a gap for the control line to pass through is formed between the first locking arm and the second locking arm, and the first locking arm and the second locking arm both have the connecting region and the locking region.

[0016] In one embodiment, the locking region of the first locking arm and the locking region of the second locking arm are both inwardly curved, so that the gap width between the locking regions is smaller than the gap width between the connecting regions.

[0017] In one embodiment, a threading notch is arranged at the connecting position between the first locking arm and the second locking arm.

[0018] In one embodiment, the central seat is provided with a mounting cavity and a guide cavity in communication, the mounting cavity and the guide cavity are arranged side by side along the radial direction of the central seat, the mounting cavity is used for mounting the first rotating shaft and the locking member, and the proximal end of the transmission member is slidably arranged in the guide cavity.

[0019] In one of the embodiments, the central seat comprises a large-diameter section and a small-diameter section arranged non-coaxially, the large-diameter section and the small-diameter section are arranged in sequence in the direction from the distal end to the proximal end, the mounting cavity is arranged on the large-diameter section, and the guide cavity extends from the large-diameter section to the small-diameter section.

[0020] The distal end of the locking member is arranged in the mounting cavity, and the proximal end of the locking member is located outside the large-diameter section.

[0021] In one of the embodiments, the transmission member comprises a driving head, a first rod portion and a second rod portion connected in sequence, the driving head and the first rod portion are arranged along the central axis of the valve clamping device, the first rod portion and the second rod portion are arranged eccentrically, the driving head is hinged to all the small arms, and the proximal end of the second rod portion is slidably arranged in the central seat.

[0022] A valve clamping system, the valve clamping device comprises a delivery device, a first control line, a second control line and the valve clamping device according to any one of the above.

[0023] The distal end of the delivery device is connected to the central seat of the valve clamping device, the distal end of the first control line is connected to the locking member of the valve clamping device, and the distal end of the second control line is connected to the transmission member of the valve clamping device.

[0024] The valve clamping device and the valve clamping system have a first shape and a second shape, and the shape of the locking member can be adjusted to lock or unlock the first rotating shaft during operation. By locking the first rotating shaft, the clamping member cannot be opened by itself or under the impact of blood during the delivery of the valve clamping device and after being sent to the lesion site, ensuring the safety of the operation and the treatment effect of the valve clamping device. By unlocking the first rotating shaft, the clamping member can be rotated around the first rotating shaft under the driving of the transmission member until the corresponding heart valve leaflet is clamped, thereby achieving the purpose of repairing the heart valve. It can be seen that the above-mentioned valve clamping device can effectively lock or unlock the clamping member by using the locking member only. This not only makes the valve clamping device firmly locked by the locking member after being sent to the lesion site, but also simplifies the structure of the valve clamping device, reduces the number of parts of the valve clamping device, and reduces the assembly difficulty of the valve clamping device. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 The valve clamping device provided in one of the embodiments of the present application is a three-dimensional structure diagram of the valve clamping device when the clamping member is opened.

[0026] Figure 2 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0027] Figure 3 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft. Figure 2 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0028] Figure 4 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0029] Figure 5 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0030] Figure 6 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0031] Figure 7 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0032] Figure 8 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0033] Figure 9 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft.

[0034] Figure 10 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft. Figure 9 A structure schematic view of the valve clamping device provided by an embodiment of the present application when the locking member is released from locking the first rotating shaft. DETAILED DESCRIPTION

[0035] To make the above objectives, features and advantages of the present application more apparent, specific embodiments of the present application are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. However, the present application can be practiced in a variety of ways beyond the specific embodiments described herein without departing from the scope of the present application, and it is understood that similar improvements can be made by those skilled in the art in light of the foregoing description. Therefore, the present application is not limited to the following disclosed specific embodiments.

[0036] In the description of the application, it should be understood that, if there are these terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like, these terms indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the application.

[0037] In addition, if there are these terms "first", "second", these terms are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first", "second" can explicitly or implicitly include at least one of the features. In the description of the application, if the term "multiple" appears, the meaning of "multiple" is at least two, such as two, three, etc., unless otherwise explicitly specified and limited.

[0038] In this application, unless otherwise explicitly specified and limited, if there are terms such as "mounting", "connecting", "connecting", "fixing" and the like, these terms should be broadly understood. For example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise explicitly limited. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.

[0039] In this application, unless otherwise explicitly specified and limited, if there are similar descriptions such as "first feature on or under second feature", the meaning can be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature "above", "above" and "above" of the second feature can be that the first feature is directly above or obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature "below", "below" and "below" of the second feature can be that the first feature is directly below or obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0040] It is to be noted that when an element such as a layer, film, region, or substrate is referred to as being "on" another element, it can be directly on the other element or intervening elements can also be present. In contrast, when an element is referred to as being "directly on" another element, there are no intervening elements present. It will be understood that, when a part is referred to as being "connected" to another part, it can be directly connected to the other part or intervening parts can also be present. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed terms. As used herein, the term "about" when used in reference to a particular recited numerical value, means that the value can vary from the recited value by no more than 1%, 2%, 5%, 10%, 15%, or 20%. As used herein, the terms "horizontal" and "vertical" are intended to refer to the orientation of the device as it is typically held and used by a user, and are not intended to refer to absolute physical orientations of the device.

[0041] It is to be noted that "distal" and "proximal" throughout the text are only for indicating relative position relationship, the "distal" of a component refers to the end which enters the patient's body first and / or is farther away from the operator during normal operation, while the "proximal" refers to the end which enters the patient's body later and / or is closer to the operator.

[0042] Referring to Figures 1 to 3 An embodiment of the present application provides a valve clamping device 10, which comprises a center seat 100, a locking member 200, a transmission member 300, and a plurality of clamping members 400.

[0043] The clamping members 400 are arranged around the center seat 100. The number of the clamping members 400 can be 2, which can be respectively Figure 4 The first clamping member 400a and the second clamping member 400b are oppositely arranged as shown. The first clamping member 400a and the second clamping member 400b can each comprise a support arm and a capture arm 430, wherein the support arm comprises a large arm 410 and a small arm 420 which are hingedly connected. The large arm 410 is hingedly connected to the center seat 100 through a first rotating shaft 510, wherein the large arm 410 which is distal to the center seat 100 can be fixed to one end of the first rotating shaft 510 by welding or the like to avoid falling off, and the large arm 410 which is proximal to the center seat 100 is directly sleeved on the first rotating shaft 510. The small arm 420 is hingedly connected to the transmission member 300 through a second rotating shaft 520, and the small arm 420 is hingedly connected to the large arm 410 through a third rotating shaft 530. The capture arm 430 is connected to the center seat 100, and the capture arm 430 can be made of elastic material or shape memory material (such as nickel-titanium alloy). The capture arm 430 is provided with a traction hole 430a for the control wire to pass through, and the capture arm 430 can be folded to be close to or in contact with the center seat 100 under the traction of the control wire. When the control wire is relaxed, the capture arm 430 can rebound towards the large arm 410 and cooperate with the large arm 410 to capture the heart valve leaflet.

[0044] The locking member 200 is arranged in the center seat 100 and has a first form and a second form. When the locking member 200 is in the first form, the locking member 200 is used to lock the first rotating shaft 510. When the locking member 200 is in the second form, the locking member 200 is used to unlock the first rotating shaft 510. When the locking member 200 unlocks the first rotating shaft 510, the first rotating shaft 510 can move along the axial direction of the center seat 100 to open or close the support arm.

[0045] It should be noted that the support arm can rotate under the driving of the first rotating shaft 510. Therefore, when the first rotating shaft 510 is locked by the locking member 200, the support arm is also fixed.

[0046] The valve clamping device 10 of the embodiment can be used as a coaptation repair implant in the field of structural heart disease intervention treatment. The valve clamping device 10 can reach the designated position through a transvascular minimally invasive approach, and the repair treatment of the heart leaflet valve can be realized by clamping of the clamping member 400 of the valve clamping device 10.

[0047] The operation process of the valve clamping device 10 will be described below by taking the repair of the mitral valve as an example. The first clamping member 400a is used to clamp the anterior leaflet of the mitral valve, and the second clamping member 400b is used to clamp the posterior leaflet of the mitral valve.

[0048] Before the valve clamping device 10 is delivered into the patient's body, the first clamping member 400a and the second clamping member 400b of the valve clamping device 10 are closed to make the first clamping member 400a and the second clamping member 400b in the fully collapsed state, and the locking member 200 is adjusted to the first mode to lock the first rotating shaft 510, so that the support arms of the first clamping member 400a and the second clamping member 400b cannot rotate around the center seat 100 to expand when the valve clamping device 10 is delivered into the patient's body. The valve clamping device 10 is sent into the heart through the femoral vein puncture by using the delivery device, and under the guidance of three-dimensional ultrasound, the large arms 410 of the first clamping member 400a and the large arms 410 of the second clamping member 400b are passed through the middle part of the anterior and posterior leaflets of the mitral valve; then, the locking member 200 is adjusted to the second mode to release the locking of the first rotating shaft 510, so that the support arms of the first clamping member 400a and the second clamping member 400b can rotate around the center seat 100, and then the transmission member 300 is driven to move along the axial direction of the center seat 100, and in the moving process, the transmission member 300 can in turn drive the small arms 420 and the large arms 410 of the first clamping member 400a and the small arms 420 and the large arms 410 of the second clamping member 400b to rotate around the center seat 100 until the large arms 410 of the first clamping member 400a abut against the clamping position of the anterior leaflet of the mitral valve and the large arms 410 of the second clamping member 400b abut against the clamping position of the posterior leaflet of the mitral valve. Then, the control lines on the capture arms 430 of the first clamping member 400a and the second clamping member 400b are released, so that the anterior leaflet of the mitral valve is clamped between the large arms 410 and the capture arms 430 of the first clamping member 400a, and the posterior leaflet of the mitral valve is clamped between the large arms 410 and the capture arms 430 of the second clamping member 400b. Then, the locking member 200 is adjusted to the first mode to lock the first rotating shaft 510, so that the support arms of the first clamping member 400a and the second clamping member 400b cannot rotate again. Finally, the delivery device and the control lines are withdrawn out of the patient's body.

[0049] The locking member 200 has a first shape and a second shape, and the shape of the locking member 200 can be adjusted to lock or unlock the first rotating shaft 510 during operation. By locking the first rotating shaft 510, the support arm of the clamping member 400 cannot be opened by itself or under the impact of blood during the delivery of the valve clamping device 10 and after being sent to the lesion site to be closed, thereby ensuring the safety of the operation and the treatment effect of the valve clamping device 10. By unlocking the first rotating shaft 510, the large arm 410 of the clamping member 400 can be rotated around the first rotating shaft 510 under the driving of the transmission member 300 and clamped to the corresponding heart valve leaflet through the cooperation of the capture arm 430 after the valve clamping device 10 is delivered to the vicinity of the target tissue, thereby achieving the purpose of repairing the heart valve. As can be seen, the valve clamping device 10 can effectively lock or unlock the clamping member 400 through the locking member 200, which not only enables the valve clamping device 10 to be firmly locked after being sent to the lesion site to be closed through the locking member 200, but also simplifies the structure of the valve clamping device 10, reduces the number of parts of the valve clamping device 10, and reduces the assembly difficulty of the valve clamping device 10.

[0050] In some embodiments of the present application, the locking member 200 can be a shape memory material (such as nickel-titanium alloy), and the original shape of the locking member 200 is the first shape. The locking member 200 of such material can have the ability to rebound to the original shape after deformation through heat treatment during the forming process. The locking member 200 can be transformed from the first shape to the second shape under the action of external force, and when the external force on the locking member 200 is removed, the locking member 200 returns to the original shape (i.e., the first shape).

[0051] In some embodiments of the present application, referring to Figure 3 , the locking member 200 is arranged along the axial direction of the center seat 100, and the deformation direction of the locking member 200 is parallel to the axial direction of the center seat 100. Among them, Figure 3 , the black solid double-headed arrow in Figure 3 represents the axial direction of the center seat 100, and the black dashed double-headed arrow represents the deformation direction of the locking member 200. Compared with the inclined arrangement of the locking member 200, when the force is applied to the locking member 200 along the axial direction of the center seat 100, the locking member 200 can produce the same deformation amount when moving a preset length along the axial direction of the center seat 100 under the action of the force, which can effectively lock or unlock the first rotating shaft 510 and provide more reliable locking stability for the first rotating shaft 510.

[0052] Referring to Figure 5 and Figure 6In some embodiments of the present application, the locking member 200 can include a first locking arm 210 and a second locking arm 220 connected together, and a gap 200a is formed between the first locking arm 210 and the second locking arm 220 for the control line to pass through. In operation, the control line is first passed through the gap 200a, and then the control line is pulled to adjust the locking member 200 from the first mode to the second mode. When the control line is released, the locking member 200 can return to the first mode. The gap 200a can also avoid the transmission of the transmission member 300.

[0053] In some embodiments of the present application, the locking member 200 is provided with a locking hole for the first rotating shaft 510 to pass through, that is, Figure 5 The first locking arm 210 is provided with a locking hole 210a, and the second locking arm 220 is provided with a locking hole 220a. When the locking member 200 is in the first mode, the locking member 200 tightly holds the first rotating shaft 510 in the locking hole through the frictional contact with the first rotating shaft 510, and when the locking member 200 is in the second mode, the locking member 200 releases the first rotating shaft 510. When the locking member 200 deforms, the locking hole also deforms correspondingly, so that the locking member 200 releases or tightly holds the first rotating shaft 510, which can simplify the structure of the locking member 200 and facilitate operation.

[0054] In some embodiments of the present application, the locking member 200 has a connecting region and a locking region (that is, Figure 5 and Figure 6 The first locking arm 210 is provided with a connecting region 210b and a locking region 210c, and the second locking arm 220 is provided with a connecting region 220b and a locking region 220c. The connecting region is connected with the center seat 100, the locking region is curved, the mode of the locking region can be switched between the first mode and the second mode, and the locking hole is arranged in the locking region. The curved locking region makes the locking hole not a circle when in the first mode, but in a state of being squeezed up and down, which can increase the deformation degree of the locking member 200 and thus can increase the squeezing force on the first rotating shaft 510. When the locking hole is in the second mode, the squeezing amplitude of the elongated locking hole up and down is reduced, so that the first rotating shaft 510 is separated from the squeezing of the locking hole, thereby releasing the locking.

[0055] Optionally, the connecting region 200b of the locking member 200 can be connected with the center seat 100 by welding, screw connection or the like.

[0056] In some embodiments of the present application, the connecting region 200b of the locking member 200 can be connected with the center seat 100 by welding, screw connection or the like. Figure 5 and Figure 6, the locking region 210c of the first locking arm 210 and the locking region 220c of the second locking arm 220 are bent inwardly, i.e. the locking region 210c of the first locking arm 210 is bent toward the locking region 220c of the second locking arm 220, and the locking region 220c of the second locking arm 220 is bent toward the locking region 210c of the first locking arm 210, so that there is a small gap between the locking region 210c of the first locking arm 210 and the locking region 220c of the second locking arm 220, and the width of the gap is smaller than the width of the gap between the connecting region 210b of the first locking arm 210 and the connecting region 220b of the second locking arm 220. In this way, the size of the space occupied by the locking member 200 can be reduced, so that the size of the valve clamping device 10 can be reduced.

[0057] Optionally, referring to Figure 5 and Figure 7 , the connecting part between the first locking arm 210 and the second locking arm 220 is provided with a threading gap 200b. The threading gap 200b facilitates the threading of the control line. As an example, referring to Figure 5 and Figure 6 , the first locking arm 210 is provided with a transition region 210d, and the second locking arm 220 is provided with a transition region 220d, the transition region 210d of the first locking arm 210 is connected to the transition region 220d of the second locking arm 220 at the proximal end to connect the first locking arm 210 and the second locking arm 220 into a whole; wherein referring to Figure 5 and Figure 7 , the threading gap 200b is arranged at the proximal end of the transition region 210d of the first locking arm 210 and the transition region 220d of the second locking arm 220.

[0058] In some embodiments of the present application, referring to Figure 8 , the central seat 100 is provided with a mounting cavity 100a and a guide cavity 100b in communication, the mounting cavity 100a and the guide cavity 100b are arranged side by side along the radial direction of the central seat 100, the mounting cavity 100a is used for mounting the first rotating shaft 510 and the locking member 200, and the proximal end of the transmission member 300 is slidably arranged in the guide cavity 100b. The guide cavity 100b plays a guiding role for the movement of the transmission member 300, which is beneficial to the opening and closing of the clamping member 400. It can be understood that the guide cavity 100b is arranged along the movement direction of the transmission member 300, and the proximal end and the distal end of the guide cavity 100b and the mounting cavity 100a are in communication with the external environment.

[0059] Optionally, referring to Figure 7The center seat 100 is further provided with a threading hole 100c which is communicated with the guide cavity 100b. In operation, the delivery device is first connected with the center seat 100, and then the distal end of the control wire is extended out of the distal end of the delivery device and then enters the guide cavity 100b through the threading hole 100c of the center seat 100 to be connected with the transmission member 400, so that the transmission member 300 is driven to slide along the center seat 100 by pulling the control wire.

[0060] Further, referring to Figure 8 The center seat 100 can include a large-diameter section 110 and a small-diameter section 120 which are arranged non-coaxially and sequentially from the distal end to the proximal end. The mounting cavity 100a is arranged on the large-diameter section 110, and the guide cavity 100b extends from the large-diameter section 110 to the small-diameter section 120. The distal end of the locking member 200 is arranged in the mounting cavity 100a, and the proximal end of the locking member 200 can be located outside the large-diameter section 110. The center seat 100 has an irregular structure, which can be regarded as a notch arranged at the proximal end of a regular cylindrical structure. The distal end of the locking member 200 is located in the large-diameter section of the center seat 100, and the proximal end of the locking member 200 can be located in the notch. In this way, the proximal end of the locking member 200 can be conveniently controlled by the control wire, and the weight of the center seat 100 can be reduced, so that the heart burden of the patient is not increased. It can be understood that the arm of the large-diameter section 110 is provided with a mounting hole 110a for the first rotating shaft 510 to pass through, and the mounting hole 110a is communicated with the mounting cavity 100a.

[0061] Alternatively, referring to Figure 8 The distal end 110a of the large-diameter section 110 can be provided with a hollow structure, so as to further reduce the weight of the center seat 100.

[0062] Referring to Figure 8 For the center seat 100 with the above-mentioned special-shaped structure, since the proximal end of the locking member 200 is located outside the center seat 100, the side of the locking member 200 close to the small-diameter section 120 is provided with a threading notch 200b, and the opposite side can not be provided with a threading notch 200b.

[0063] Referring to Figure 3In some embodiments of the present application, the transmission member 300 comprises a driving head 310, a first rod portion 320 and a second rod portion 330 connected in sequence, the driving head 310 and the first rod portion 320 are arranged along the central axis of the valve clamping device 10, the first rod portion 320 and the second rod portion 330 are arranged eccentrically (i.e. the central axes of the two are not collinear), the driving head 310 is hingedly connected with the clamping member 400, and the proximal end of the second rod portion 330 is slidably arranged in the central seat 100. In this way, the eccentric arrangement of the first rod portion 320 and the second rod portion 330 can ensure that the transmission member 300 does not interfere with the first rotating shaft 510 and the locking member 200 during sliding in the central seat 100, and can also reduce the processing difficulty and production cost.

[0064] Optionally, an operation hole (not shown in the drawings) for a control line is arranged on the proximal end of the second rod portion 330, and the distal end of the control line can enter the central seat 100 and be connected with the second rod portion 330 after being pulled out by the distal end of the delivery device.

[0065] The components in the valve clamping device 10 described above are all made of biocompatible materials to prevent further damage to the heart valve after clamping.

[0066] On the other hand, the embodiments of the present application also provide a valve clamping system, which comprises a delivery device, a first control line, a second control line and the valve clamping device 10 described above; the distal end of the delivery device is connected with the central seat 100 of the valve clamping device 10, the distal end of the first control line is located outside the delivery device and is connected with the locking member 200 of the valve clamping device 10, and the distal end of the second control line is located outside the delivery device and is connected with the transmission member 300 of the valve clamping device 10.

[0067] In the present application, the clamping member 400 of the valve clamping device further comprises a plurality of capture arms 430 connected with the central seat 100 in sequence in the circumferential direction; and the valve clamping system further comprises a plurality of third control lines, the distal ends of which are located outside the delivery device and are connected with the corresponding capture arms 430.

[0068] As an example, the first control line, the second control line and the third control line described above can all be control lines.

[0069] As an example, the delivery device described above can comprise a sheath assembly and a handle arranged on the proximal end of the sheath assembly, the proximal ends of the first control line, the second control line and the third control line are connected with the handle, and the distal ends of the first control line, the second control line and the third control line are pulled out by the sheath assembly. By operating the handle, the first control line, the second control line or the third control line is pulled, so as to control the locking member 200, the transmission member 300 and the clamping member 400 of the valve clamping device 10.

[0070] The locking member 200 of the valve clamping device 10 has a first form and a second form, and the form of the locking member 200 can be adjusted to lock or release the locking of the first rotating shaft 510 during the operation, wherein the locking of the first rotating shaft 510 can prevent the support arm of the clamping member 400 from being opened by itself or under the impact of blood during the delivery of the valve clamping device 10 and after the valve clamping device 10 is sent to the lesion location and folded, thereby ensuring the safety of the operation and the treatment effect of the valve clamping device 10; by releasing the locking of the first rotating shaft 510, the large arm 410 of the clamping member 400 can be rotated around the first rotating shaft 510 under the driving of the transmission member 300 and clamped to the corresponding heart valve leaflet through the cooperation of the capture arm 430 after the valve clamping device 10 is delivered to the vicinity of the target tissue, thereby achieving the purpose of repairing the heart valve. It can be seen that the valve clamping device 10 can effectively lock or release the locking of the clamping member 400 through the locking member 200, which not only allows the valve clamping device 10 to be firmly locked after being sent to the lesion location and folded through the locking member 200, but also simplifies the structure of the valve clamping device 10, reduces the number of parts of the valve clamping device 10, and reduces the assembly difficulty of the valve clamping device 10.

[0071] The technical features of the above-described embodiments can be combined in any manner. To make the description concise, all possible combinations of the technical features in the above-described embodiments are not described, but as long as the combinations of the technical features do not exist contradictions, they should be considered as the scope of the present disclosure.

[0072] The above-described embodiments only express several implementation manners of the present application, and the description is more specific and detailed, but it should not be understood as a limitation on the patent scope of the application. It should be pointed out that for ordinary skilled persons in the art, some modifications and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the patent protection scope of the present application should be subject to the appended claims.

Claims

1. A valve clamping device, characterized in that, include: Center seat, locking components, transmission components, and multiple support arms; The support arm is arranged around the center seat and includes a large arm and a small arm that are hinged together. The large arm is hinged to the center seat through a first pivot, and the small arm is connected to the transmission component through a second pivot. The locking member is disposed in the center seat and has a first form and a second form. When the locking member is in the first form, it is used to lock the first rotating shaft. When the locking member is in the second form, it is used to release the lock on the first rotating shaft. When the locking member releases the lock on the first rotating shaft, the first rotating shaft can slide along the axial direction of the center seat to open or close the support arm. The locking member is provided with a locking hole for the first rotating shaft to pass through. When the locking member is in the first state, the locking member holds the first rotating shaft in the locking hole through frictional contact with the first rotating shaft. When the locking member is in the second state, the locking member releases the first rotating shaft.

2. The valve clamping device according to claim 1, characterized in that, The locking element is made of shape memory material, and the locking element is in the first form when no external force is applied.

3. The valve clamping device according to claim 1, characterized in that, The locking member is arranged along the axial direction of the center seat, and the deformation direction of the locking member is parallel to the axial direction of the center seat.

4. The valve clamping device according to claim 1, characterized in that, The locking member has a connecting area and a locking area. The connecting area is connected to the center seat. The locking area is curved and its shape can switch between a first shape and a second shape. The locking hole is provided in the locking area.

5. The valve clamping device according to claim 4, characterized in that, The locking member includes a first locking arm and a second locking arm connected to each other, with a gap formed between the first locking arm and the second locking arm for the passage of a control line, wherein the first locking arm and the second locking arm each have the connecting area and the locking area.

6. The valve clamping device according to claim 5, characterized in that, Both the locking region of the first locking arm and the locking region of the second locking arm are bent inward, such that the gap width between the locking regions is smaller than the gap width between the connecting regions.

7. The valve clamping device according to claim 5, characterized in that, A notch for threading is provided at the connection point between the first locking arm and the second locking arm.

8. The valve clamping device according to any one of claims 1 to 7, characterized in that, The center seat is provided with a communicating mounting cavity and a guide cavity. The mounting cavity and the guide cavity are arranged side by side along the radial direction of the center seat. The mounting cavity is used to install the first rotating shaft and the locking member. The proximal end of the transmission member is slidably disposed in the guide cavity.

9. The valve clamping device according to claim 8, characterized in that, The center seat includes a large-diameter section and a small-diameter section that are not coaxially arranged. The large-diameter section and the small-diameter section are arranged sequentially from the distal end to the proximal end. The mounting cavity is disposed on the large-diameter section, and the guide cavity extends from the large-diameter section to the small-diameter section. The distal end of the locking member is disposed in the mounting cavity, and the proximal end of the locking member is located outside the large-diameter section.

10. The valve clamping device according to any one of claims 1 to 7, characterized in that, The transmission component includes: a drive head, a first rod, and a second rod connected in sequence. The drive head and the first rod are both arranged along the central axis of the valve clamping device. The first rod and the second rod are eccentrically arranged. The drive head is hinged to all the forearms. The proximal end of the second rod is slidably disposed in the central seat.

11. A valve clamping system, characterized in that, The valve clamping device includes a delivery device, a first control line, a second control line, and the valve clamping device as described in any one of claims 1 to 10; The distal end of the delivery device is connected to the center seat of the valve clamping device, the distal end of the first control line is connected to the locking member of the valve clamping device, and the distal end of the second control line is connected to the transmission member of the valve clamping device.

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