In-situ nanofiber material for enhancing tumor immunogenicity and preparation method and application thereof

Abstract

The application belongs to the technical field of biomedical polymer materials, and discloses in-situ nanofiber materials for enhancing tumor immunogenicity, and a preparation method and application thereof. The application constructs in-situ nanofiber loaded with a degradable carrier, a molecular targeted drug Anlotinib and Gep nanosheet, and then the in-situ nanofiber is made into a patch and directly applied to a tumor lesion, and is combined with NIR assisted irradiation and aPD-L1 treatment. The application not only improves the delivery efficiency of AL through local administration, and overcomes the problem of low efficiency of systemic administration through a nanocarrier, but also takes inhibition of excessive growth of HCC blood vessels as a starting point, combines PTT and ICB treatment, and enhances the immunogenicity of a residual tumor after a three-mode combined treatment cascade, and enhances an immune response. Meanwhile, the application has the advantages of simple components, flexible formula, easy preparation and the like. Therefore, the in-situ nanofiber material has wide practical application value in the field of tumor treatment.

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