Self-assembled hydrogels based on natural product catechins, their preparation methods and applications
By using catechin self-assembly to form nanofiber-like hydrogels, the complexity and high cost of preparing small molecule hydrogels in existing technologies have been solved, achieving a long-lasting drug delivery effect with anti-inflammatory activity.
CN117046406BActive Publication Date: 2026-07-17ACADEMY OF MILITARY MEDICAL SCIENCES
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ACADEMY OF MILITARY MEDICAL SCIENCES
- Filing Date
- 2023-08-15
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
In the existing technology, small molecule hydrogels require complex and rigorous experimental verification of biocompatibility and bioactivity, which increases the complexity and cost of preparation. In addition, the lack of hydrogels formed by compounds that have been approved by the FDA makes long-term drug delivery difficult.
Method used
Small molecule hydrogels are formed by self-assembly of levorotatory isomers, devorotatory isomers or mixtures thereof using heating and cooling methods, resulting in nanofiber-like structures.
Benefits of technology
The catechin self-assembled hydrogel exhibits significant anti-inflammatory activity, inhibits LPS-induced RAW264.7NO release, and demonstrates good biocompatibility and bioactivity.
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Figure CN117046406B_ABST
Abstract
This invention discloses a self-assembled hydrogel based on the natural product catechin, its preparation method, and its application, relating to the field of pharmaceutical preparation technology. The invention includes the following steps: 1) dissolving catechin in a water-soluble medium; 2) heating the water-soluble medium until dissolved; 3) cooling to room temperature to obtain a catechin self-assembled hydrogel. The innovation of this invention lies in the discovery that the active substance catechin (levorotatory isomer, dextrorotatory isomer, and a mixture of the two isomers) can be induced to self-assemble into a hydrogel through heating and cooling. In the above hydrogel, the catechin self-assembles into nanofibers. Compared to free catechin, the catechin self-assembled hydrogel can more significantly inhibit LPS-induced RAW264.7NO release, exhibiting good anti-inflammatory activity.
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