Preparation method of composite hydrogel and composite hydrogel
CN117069962BActive Publication Date: 2026-08-28SUZHOU UNIV
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Patent Information
- Application Number
- CN202310895498.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-07-20
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2043-07-20
AI Technical Summary
Benefits of technology
[0020]有益效果：本发明实施例提供一种复合水凝胶的制备方法，包括，制备甲基丙烯酸酯化明胶(GelMA)；S2：对蚕丝脱胶液进行分离，获取HMSS溶液，其中HMSS是指分子量＞30kDa的丝胶；S3：HMSS/GelMA复合水凝胶的制备：将已制备好的GelMA溶解在去离子水中，并加入光引发剂LAP，得到GelMA凝胶体系，然后与HMSS溶液，混合均匀，得到预聚混合物，将预聚混合物在紫外光下进行光照，获取HMSS/GelMA复合水凝胶，采用这种方式制备的HMSS/GelMA复合水凝胶其孔隙率高，同时具备良好的强度性能，满足组织修复等方向的应用，本发明同时还提供应用该制备方法制备的复合水凝胶。
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Abstract
The embodiment of the present application provides a preparation method of a composite hydrogel, comprising the following steps: S1, preparing methacrylated gelatin (GelMA); S2, separating a degumming solution of silk to obtain an HMSS solution, wherein HMSS refers to sericin with a molecular weight greater than 30kDa; S3, preparing the HMSS / GelMA composite hydrogel: dissolving the prepared GelMA in deionized water, adding a photoinitiator LAP to obtain a GelMA gel system, then mixing the GelMA gel system with the HMSS solution to obtain a pre-polymer mixture, and irradiating the pre-polymer mixture under ultraviolet light to obtain the HMSS / GelMA composite hydrogel; the HMSS / GelMA composite hydrogel prepared in this way has high porosity and good strength performance, and meets the application in the direction of tissue repair; and the present application further provides the composite hydrogel prepared by using the preparation method.
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