A nuclide automatic distribution device

Abstract

The present invention discloses a nuclide automatic distribution device, which includes a collection bottle for collecting and outputting the nuclide stock solution to be distributed; a storage bottle for outputting a diluent; a first distribution valve connected to the collection bottle, a two-way pump connected to the first distribution valve, and a second distribution valve connected to the two-way pump, which is used to control the flow rate and passage during the nuclide distribution process; a number of independently startable passages are provided on both the first distribution valve and the second distribution valve; the storage bottle is respectively connected to one passage of the first distribution valve and the second distribution valve. The nuclide automatic distribution device of the present invention can not only achieve the distribution of the nuclide stock solution and handle the failure of abnormal stock solution distribution, but also conveniently complete the dilution of the stock solution and the cleaning of the device, etc., greatly reducing the radiation of the nuclide to the operator.

Description

Technical Field

[0001] The present invention relates to the field of radiopharmaceutical technology, and particularly to a nuclide automatic distribution device. Background Art

[0002] Positron emission tomography (PET) imaging observes and studies the in-vivo physiological mechanisms through positron imaging agents, and obtains information such as in-vivo metabolic pathways, biomolecular mechanisms, functions of receptors and enzymes in real time, in vivo and non-invasively. As one of the modern advanced functional molecular imaging technologies, PET has been widely used in the diagnosis of fields such as tumors and neurodegenerative diseases.

[0003] The key to the application development of PET technology lies in the development of PET imaging agents. Due to the short half-life of positron nuclides, the labeling methods of PET imaging agents require characteristics such as fewer steps, short reaction time, high efficiency, and easy operation, which also makes the demand for radioactive nuclide ions and the demand for quantitative labeling continuously increase.

[0004] Radioactive Nuclide 18 F is generally produced by a cyclotron, and then labeled onto different chemical substrates through a chemical synthesis module (also called a synthesizer) to synthesize various radioactive drugs for clinical use. The cyclotron passes through 18 O(p,n) 18 F nuclear reaction, and bombards 18 O]H2O with a certain proton beam continuously to generate 18 F-F - . However, the 18 F-F - in the stock solution produced by the cyclotron has not been processed. Therefore, in most accelerator centers, the actual demand for nuclides is less than the maximum production of the equipment, or the concentration of the actual demand for nuclides is less than the concentration produced by the equipment. Both of these situations result in waste of resources. The main reason is that the target water (H2 18 O) of the accelerator is transmitted once, and it is impossible to separate the excess nuclides or distribute them to different synthesis modules for use. Therefore, quantitative distribution of the stock solution can make the nuclides be utilized most fully.

[0005] The Chinese utility model patent with the patent number ZL 201320747804.9 discloses an automatic fluoride ion dispensing device. Although this device can quantitatively distribute the stock solution produced by the cyclotron, the metering device for dispensing uses a quantitative injection pump, and the quantitative injection pump has problems such as being unable to handle distribution abnormalities in a timely manner and having a slow distribution speed when the destination is far away. Moreover, there is no device for automatically diluting the stock solution and the process of an automatic cleaning device in this device. If the stock solution is manually diluted by an operator, it will cause serious radiation to the operator. Summary of the Invention

[0006] The object of the present invention is to provide a nuclide automatic distribution device aiming at the problems in the prior art that the automatic dilution and automatic distribution of trace nuclides cannot be realized, resulting in vulnerability to radiation and waste of resources. This device can not only achieve the distribution of the original nuclide solution, handle the failure of abnormal original solution distribution, but also conveniently complete the dilution of the original solution and the cleaning of the device, greatly reducing the radiation of nuclides to operators.

[0007] The present invention is realized through the following technical solutions:

[0008] A nuclide automatic distribution device, comprising:

[0009] A collection bottle for collecting and outputting the original nuclide solution to be distributed;

[0010] A liquid storage bottle for outputting a diluent;

[0011] A first distribution valve connected to the collection bottle, a two-way pump connected to the first distribution valve, and a second distribution valve connected to the two-way pump, for controlling the flow rate and passage during the nuclide distribution process;

[0012] A number of independently startable passages are provided on both the first distribution valve and the second distribution valve; the liquid storage bottle is respectively connected to one passage of the first distribution valve and the second distribution valve.

[0013] For the nuclide automatic distribution device as described above, a dilution pipeline and a cleaning pipeline are provided in the liquid storage bottle. The cleaning pipeline is connected to one passage of the first distribution valve, and the dilution pipeline is connected to one passage of the second distribution valve.

[0014] For the nuclide automatic distribution device as described above, the collection bottle is communicated with the two-way pump through the first distribution valve, and the two-way pump is communicated with any one passage of the second distribution valve for distributing the original nuclide solution, so that when the two-way pump rotates forward, the original nuclide solution in the collection bottle is pumped into the passage to complete the distribution of the original solution, and when the two-way pump rotates backward, the original solution with abnormal distribution is pumped back into the collection bottle.

[0015] For the nuclide automatic distribution device as described above, the cleaning pipeline in the liquid storage bottle is communicated with the two-way pump through the first distribution valve, and the two-way pump is connected to any one passage of the second distribution valve for distributing the original nuclide solution, so that when the two-way pump rotates forward, the washing of the nuclide automatic distribution device is completed.

[0016] For the nuclide automatic distribution device as described above, the dilution pipeline in the liquid storage bottle is communicated with the two-way pump through the second distribution valve, and the two-way pump is communicated with the collection bottle through the first distribution valve, so that when the two-way pump rotates backward, the diluent in the liquid storage bottle is pumped into the collection bottle to dilute the original nuclide solution.

[0017] For the nuclide automatic distribution device as described above, the number of independently actuated passages in the first distribution valve should be not less than 2, and the number of independently actuated passages in the second distribution valve should be not less than 3. Preferably, the number of independently actuated passages in the first distribution valve is 2 - 4, and more preferably 3; preferably, the number of independently actuated passages in the second distribution valve is 3 - 9, and more preferably 8.

[0018] For the nuclide automatic distribution device as described above, air filter membranes are provided on both the first distribution valve and the second distribution valve. Preferably, the air filter membrane is disposed on any one of the passages in the first distribution valve and the second distribution valve.

[0019] For the nuclide automatic distribution device as described above, the two-way pump is electrically connected to the automatic control system for adjusting the flow rate of the two-way pump.

[0020] For the nuclide automatic distribution device as described above, the two-way pump is a peristaltic pump.

[0021] For the nuclide automatic distribution device as described above, the nuclide stock solution to be distributed in the collection bottle is target water containing 18 F-F - , and the diluent in the liquid storage bottle is water.

[0022] For the nuclide automatic distribution device as described above, the collection bottle is further connected to an accelerator beam delivery pipeline.

[0023] Compared with the prior art, the present invention has the following advantages:

[0024] 1. The distribution device of the present invention has a simple structure, can accurately distribute the nuclide stock solution, can also dilute the nuclide stock solution in the collection bottle, and can automatically clean the device, greatly reducing the radiation of nuclides to the operator.

[0025] 2. By providing a two-way pump in the device, when the pump rotates forward, the nuclide stock solution to be distributed in the collection bottle can be distributed to the required passages; or the diluent in the liquid storage bottle can be distributed to each passage for cleaning the device; when the pump rotates backward, the diluent in the liquid storage bottle can be transported to the collection bottle for dilution; the functions of the device are more diverse, and at the same time, the work efficiency of the operator is improved.

[0026] 3. By electrically connecting the two-way pump to the automatic control system, modular connection and control of the nuclide distribution device are achieved, that is, remote control of the distribution amount of the nuclide stock solution via the Internet is realized, the operation is simple, and the distribution is more accurate.

[0027] 4. By providing a two-way pump, the two-way pump, the multi-way first distribution valve, and the second distribution valve can perform fault handling by means such as back-pumping the undistributed stock solution and changing the passage.

[0028] 5. By selecting the two-way pump as a peristaltic pump, the peristaltic pump can continuously apply pressure, enabling faster completion of distribution to destinations farther away. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The following further elaborates on the specific embodiments of the present invention in conjunction with the drawings, where:

[0030] Figure 1 is a schematic structural diagram of the nuclide automatic distribution device of the present invention. SPECIFIC EMBODIMENTS

[0031] To enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the drawings and specific embodiments.

[0032] As Figure 1 shown, a nuclide automatic distribution device in the present invention includes: a collection bottle 1 for collecting and outputting the undistributed nuclide stock solution, and a storage bottle 2 for outputting a diluent. It further includes a first distribution valve 3 connected to the collection bottle 1, a two-way pump 4 connected to the first distribution valve 3, and a second distribution valve 5 connected to the two-way pump 4. The two-way pump 4 is used to control the flow rate during the nuclide distribution process, and the second distribution valve 5 is used to control the passage during the nuclide distribution process; the first distribution valve 3 and the second distribution valve 5 are each provided with a plurality of independently actuable passages along the axial direction; the storage bottle 2 is respectively connected to one passage in the first distribution valve 3 and the second distribution valve 5.

[0033] In the present invention, by providing a two-way pump, a first distribution valve, and a second distribution valve in the device, when the two-way pump rotates forward, the undistributed nuclide stock solution in the collection bottle can be distributed to the required passages through the first distribution valve, the two-way pump, and the second distribution valve; or the diluent in the storage bottle can be distributed to each passage through the first distribution valve, the two-way pump, and the second distribution valve for cleaning the device; when the two-way pump rotates backward, the diluent in the storage bottle can be transported to the collection bottle through the second distribution valve, the two-way pump, and the first distribution valve; thus, the nuclide distribution device can not only accurately distribute the nuclide stock solution, but also dilute the nuclide stock solution in the collection bottle, and can automatically clean the device, greatly reducing the radiation of the nuclide to the operator. Moreover, the functions of the device are more diverse and comprehensive, improving the work efficiency of the operator.

[0034] Specifically, in this embodiment, a dilution pipeline 21 and a cleaning pipeline 22 are provided in the storage bottle 2. The cleaning pipeline 22 is connected to one passage in the first distribution valve 3, and the dilution pipeline 21 is connected to one passage in the second distribution valve 5.

[0035] In the present invention, the two-way pump 4 is electrically connected to the automatic control system 7. The modular connection and control of the nuclide distribution device are realized, that is, the distribution amount of the nuclide stock solution can be remotely controlled via the Internet, the operation is simple, and the distribution is more accurate. The flow rate of the liquid reciprocating in the two-way pump 4 can also be precisely adjusted.

[0036] As Figure 1 shown, in this embodiment, the collection bottle 1 is communicated with the two-way pump 4 through the first distribution valve 3, and the two-way pump 4 is communicated with any one of the passages for distributing the nuclide stock solution in the second distribution valve 5, so that when the two-way pump 4 rotates forward, the nuclide stock solution in the collection bottle 1 is pumped into the passage to complete the distribution of the stock solution, and when the two-way pump 4 rotates reversely, the stock solution with abnormal distribution is pumped back into the collection bottle 1.

[0037] The process of realizing the automatic sub-packaging of the nuclide stock solution by the nuclide automatic distribution device specifically includes:

[0038] (1) Transmitting the product in the target to the collection bottle 1 through the accelerator beam transport pipeline 11;

[0039] (2) Adjusting the first distribution valve 3 to adjust the pipeline interface of the two-way pump 4 to the state of being connected to the output pipeline 12 of the collection bottle 1;

[0040] (3) Subsequently, adjusting the second distribution valve 5 to adjust the interface of the pipeline of the two-way pump 4 to the state of being connected to the independently activated passage marked as ①;

[0041] (4) Starting the program of the automatic control system 7 connected to the computer to control the two-way pump 4 to rotate forward, pumping the required quantitative volume of the nuclide stock solution from the collection bottle 1 into the independently activated passage marked as ①, and transporting it to the sub-packaging bottle in the hot cell through the ① passage for packaging.

[0042] (5) If the distribution is abnormal, start the program of the automatic control system 7 connected to the computer to control the two-way pump 4 to rotate reversely, pumping the nuclide raw material in the sub-packaging bottle in the hot cell transported through the ① passage into the collection bottle 1, re-adjusting it and then re-distributing it.

[0043] Repeating the process of the above steps (3)-(4) can continue to realize the sub-packaging of the nuclide stock solution into different sub-packaging bottles through the independently activated passages marked as ②-⑥, and complete several quantitative sub-packaging processes of the nuclide stock solution. Repeating step (5) can handle the distribution failures in the independently activated passages of ②-⑥.

[0044] In this embodiment, the cleaning pipeline 22 in the liquid storage bottle 2 is communicated with the two-way pump 4 through the first distribution valve 3, and the two-way pump 4 is connected to any one of the passages for distributing the nuclide stock solution in the second distribution valve 5, so that when the two-way pump 4 rotates forward, the washing of the nuclide automatic distribution device is completed.

[0045] The cleaning in the nuclide automatic distribution device can be carried out through the following steps:

[0046] (1) Adjust the first distribution valve 3 to adjust the pipeline interface of the two-way pump 4 to the state where it is connected to the cleaning pipeline 22 in the liquid storage bottle 2.

[0047] (2) Subsequently, adjust the second distribution valve 5 to adjust the interface of the pipeline of the two-way pump 4 to the state where it is connected to the independently activated passage marked as ①.

[0048] (3) Start the program of the automatic control system 7 connected to the computer to control the two-way pump 4 to draw the required diluent (water) from the liquid storage bottle 2 into the independently activated passage marked as ①, clean each pipeline and device, and properly collect and process the cleaning liquid.

[0049] Repeat the process of steps (2)-(3) above, and the diluent can continue to flow out from the independently activated passages marked as ②-⑥ to complete the cleaning.

[0050] In this embodiment, the dilution pipeline 21 in the liquid storage bottle 2 is connected to the two-way pump 4 through the second distribution valve 5, and the two-way pump 4 is connected to the collection bottle 1 through the first distribution valve 3, so that when the two-way pump 4 rotates in reverse, the diluent in the liquid storage bottle 2 is pumped into the collection bottle 1 to dilute the radionuclide stock solution.

[0051] When the concentration of the radionuclide ( 18 F-F - ) in the stock solution is too high, the dilution adjustment can be carried out through the following steps:

[0052] (1) Adjust the second distribution valve 5 to adjust the interface of the pipeline of the two-way pump 4 to the state where it is connected to the dilution pipeline 21 in the liquid storage bottle 2.

[0053] (2) Adjust the first distribution valve 3 to adjust the pipeline interface of the two-way pump 4 to the state where it is connected to the output pipeline 12 of the collection bottle 1.

[0054] (3) Start the program of the automatic control system 7 connected to the computer to control the two-way pump 4 to rotate in reverse to draw the required quantitative volume of diluent from the liquid storage bottle 2 into the collection bottle 1 to complete the dilution of the radionuclide stock solution.

[0055] In the present invention, the number of independently actuated passages in the first distribution valve 3 should be not less than 2. Preferably, the number of independently actuated passages in the first distribution valve is 2 - 4. In this embodiment, the number of independently actuated passages is 3; the independently actuated passages are connected to the collection bottle 1 and the liquid storage bottle 2, so that the liquid between the collection bottle 1 and the liquid storage bottle 2 can be transported one-to-one by the bidirectional pump 4. In the present invention, the number of independently actuated passages in the second distribution valve 5 should be not less than 3. Preferably, the number of independently actuated passages in the second distribution valve is 3 - 9. In this embodiment, the number of independently actuated passages is 8. The independently actuated passages are connected to the liquid storage bottle 2 and each distribution target point, so that the solution transported from the collection bottle 1 or the liquid storage bottle 2 can be processed or distributed to each target point by the bidirectional pump 4.

[0056] In the present invention, air filter membranes 6 are provided on both the first distribution valve 3 and the second distribution valve 5. For easy operation, the air filter membrane 6 of this embodiment is arranged on any one of the passages in the first distribution valve 3 and the second distribution valve 5; this reduces the internal and external pressure difference between the two distribution valves and enables the liquid in the distribution valve to flow well.

[0057] Specifically, the bidirectional pump 4 in this embodiment is a peristaltic pump. The peristaltic pump can continuously apply pressure and can complete the distribution to a farther destination more quickly.

[0058] In this embodiment, the nuclide stock solution to be distributed in the collection bottle is 18 F-F - -containing target water, and the diluent in the liquid storage bottle is water. The collection bottle is also connected to an accelerator target delivery pipeline. The accelerator target delivery pipeline 11 can input the nuclide stock solution ( 18 F-F - -containing target water) prepared by the cyclotron into the collection bottle 1, avoiding the radiation caused by manual addition.

Claims

1. An automatic nuclide distribution device, characterized in that Comprising: A collection bottle (1) for collecting and outputting the radionuclide stock solution to be dispensed; A liquid storage bottle (2) for outputting a diluent; A first dispensing valve (3) connected to the collection bottle (1), a two-way pump (4) connected to the first dispensing valve (3), and a second dispensing valve (5) connected to the two-way pump (4); A number of independently actuable passages are provided axially in both the first dispensing valve (3) and the second dispensing valve (5); the liquid storage bottle (2) is respectively connected to one passage in the first dispensing valve (3) and the second dispensing valve (5); A dilution pipe (21) and a cleaning pipe (22) are provided in the liquid storage bottle (2), the cleaning pipe (22) is connected to one passage in the first dispensing valve (3), and the dilution pipe (21) is connected to one passage in the second dispensing valve (5); The collection bottle (1) is communicated with the two-way pump (4) through the first dispensing valve (3), and the two-way pump (4) is communicated with any one passage for dispensing the radionuclide stock solution in the second dispensing valve (5), so that when the two-way pump (4) rotates forward, the radionuclide stock solution in the collection bottle (1) is pumped into the passage to complete the dispensing of the stock solution, and when the two-way pump (4) rotates backward, the stock solution with abnormal dispensing is pumped back into the collection bottle (1); The cleaning pipe (22) in the liquid storage bottle (2) is communicated with the two-way pump (4) through the first dispensing valve (3), and the two-way pump (4) is connected to any one passage for dispensing the radionuclide stock solution in the second dispensing valve (5), so that when the two-way pump (4) rotates forward, the washing of the radionuclide automatic dispensing device is completed; The dilution pipe (21) in the liquid storage bottle (2) is communicated with the two-way pump (4) through the second dispensing valve (5), and the two-way pump (4) is communicated with the collection bottle (1) through the first dispensing valve (3), so that when the two-way pump (4) rotates backward, the diluent in the liquid storage bottle (2) is pumped into the collection bottle (1) to dilute the radionuclide stock solution.

2. The nuclide automatic distribution device according to claim 1, wherein The number of independently actuable passages in the first dispensing valve (3) should be not less than 2; the number of independently actuable passages in the second dispensing valve (5) should be not less than 3.

3. The nuclide automatic distribution device according to claim 2, characterized in that Air filter membranes (6) are provided in both the first dispensing valve (3) and the second dispensing valve (5).

4. The nuclide automatic distribution device according to claim 1, characterized in that The two-way pump (4) is electrically connected to an automatic control system (7).

5. The nuclide automatic distribution device according to claim 4, wherein The two-way pump (4) is a peristaltic pump.

6. The nuclide automatic distribution device according to claim 4, wherein The radionuclide stock solution to be dispensed in the collection bottle (1) is target water containing 18 F-F - , and the diluent in the liquid storage bottle (2) is water.

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