A Chinese medicinal compound preparation for treating keloid and its preparation method

Abstract

The present invention relates to the technical field of Chinese medicine preparations, in particular to a Chinese medicine compound preparation for treating keloids and a preparation method thereof. The raw materials are composed of Trigonosciadium japonicum, Curcuma zedoariae, Astragalus membranaceus, Prunella vulgaris, Fritillaria thunbergii, raw oyster, Gleditsia sinensis, Centella asiatica, raw Atractylodes macrocephala, and Licorice. The preparation method is: after mixing the raw materials, soaking them in water, boiling over high heat, then changing to low heat, continuing to boil over low heat, filtering to obtain a medicinal liquid and medicinal residues; continuing to boil the medicinal residues over high heat until boiling, then changing to low heat, continuing to boil over low heat, filtering again to obtain a secondary medicinal liquid; combining the medicinal liquids obtained twice, concentrating, and refrigerating for standby use. The Chinese medicine compound preparation prepared by the present invention has a good therapeutic effect on keloids according to pharmacodynamic tests, and has good market promotion value and potential.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparations, in particular to a Chinese medicine compound preparation for treating keloids and a preparation method thereof. Background Art

[0002] Keloid is a benign skin tumor secondary to skin trauma or spontaneously formed. It protrudes from the skin surface and stretches outward in a round, oval or crab-foot shape. It has no tendency to spontaneously disappear. It not only affects the appearance and causes skin dysfunction, but also causes itching and pain, and even cancer, which seriously affects the patient's physical and mental health. The clinical incidence of keloid is high, about 4.5% to 16.0%.

[0003] Currently, keloids are mainly treated clinically with a combination of methods, including steroid hormone injection, intralesional injection of chemotherapy drugs (5-fluorouracil), and surgical excision. Although there are certain effects, the treatment of keloids has the characteristics of tumor diseases, such as drug resistance, side effects, and high recurrence rate.

[0004] Among them, surgical excision of keloids is to directly excise the skin lesions by surgical means and then suture them. The disadvantage of this method is that simple excision of scars outside the lesion has a very high recurrence rate, as high as 80% to 100%.

[0005] Intralesional injection of drugs: 5-fluorouracil combined with glucocorticoids, such as triamcinolone acetonide injection, is the first-line option in the 2014 edition of the International Scar Treatment Guidelines. The disadvantage of this method is that the pain of acupuncture injection is strong and some patients cannot tolerate it. In addition, long-term injection of hormones and chemotherapy drugs has the risk of causing skin atrophy, severe acne and endocrine disorders, and can seriously cause damage to important organs such as liver and kidney, hematopoietic system diseases and bone marrow suppression.

[0006] Therefore, keloids have become a focus of dermatology, and it is urgent to explore safe and effective treatment drugs and methods. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a Chinese medicinal compound preparation for treating keloid and a preparation method thereof.

[0008] In order to solve the above technical problems, this application provides the following technical solutions:

[0009] A traditional Chinese medicine compound preparation for treating keloids, wherein the raw materials are composed of Rhizoma Trigonosciae, Rhizoma Curcumae, Radix Astragali, Herba Prunellae, Fritillaria Thunbergii, Raw Oyster, Spinosa L., Centella Asiatica, Raw Atractylodes Macrocephala and Radix Glycyrrhizae.

[0010] Furthermore, the added dosage of each component of the raw material medicine is 5-10 parts of Trigonosciadium japonicum, 6-9 parts of Curcuma zedoaria, 9-30 parts of Astragalus membranaceus, 9-15 parts of Prunella vulgaris, 5-10 parts of Fritillaria thunbergii, 9-30 parts of raw oyster, 3-10 parts of Gleditsia sinensis, 15-30 parts of Centella asiatica, 6-12 parts of raw Atractylodes macrocephala, and 2-10 parts of Licorice.

[0011] Furthermore, the added dosage of each component of the raw medicine is 6 parts of Trigonosciadium japonicum, 6 parts of Curcuma zedoaria, 9 parts of Astragalus membranaceus, 9 parts of Prunella vulgaris, 9 parts of Fritillaria thunbergii, 15 parts of raw oyster, 9 parts of Gleditsia sinensis, 18 parts of Centella asiatica, 9 parts of raw Atractylodes macrocephala, and 9 parts of Licorice.

[0012] The preparation method of the Chinese medicinal compound preparation for treating keloid of the present invention specifically comprises the following steps: mixing raw materials, soaking in water for 20 to 40 minutes, decocting with high heat until boiling, then changing to low heat, and continuously decocting with low heat for 40 to 60 minutes, filtering to obtain medicinal liquid and medicinal residue; continuously decocting the medicinal residue with high heat until boiling, then changing to low heat, and continuously decocting with low heat for 20 to 40 minutes, filtering again to obtain secondary medicinal liquid; and combining the medicinal liquids obtained twice and concentrating them.

[0013] Among them, the concentration of the concentrated crude drug is 1.65g / mL.

[0014] In addition to concentrated decoction dosage forms, the raw materials can also be processed, pre-treated and extracted, and then auxiliary materials can be added to make oral liquids, granules, tablets, capsules or honey pills.

[0015] Preparation method of oral solution: boil the raw material in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, package it, sterilize it, and you will get the oral solution.

[0016] Preparation method of capsules: boil the raw material in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add ethanol to granulate, dry, and put it into capsules to obtain capsules.

[0017] Preparation method of granules: boil the raw material in boiling water for 10 minutes, take it out, stew it, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, and concentrate the extract under reduced pressure and vacuum dry it to a relative density of 1.05±0.02, high-speed centrifuge to remove impurities and purify it, cool and stand it for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, spray dry, dry granulate, and package it with aluminum-plastic composite film to obtain granules.

[0018] Tablet preparation method: boil the raw material in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add starch, granulate, and press into tablets to obtain tablets.

[0019] Preparation method of honey pills: boil the raw material in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add refined honey, stir the honey and drug powder in a ratio of 1.5:1, and prepare honey pills.

[0020] Compared with the prior art, the Chinese medicinal compound preparation for treating keloid and the preparation method thereof of the present invention have at least the following beneficial effects:

[0021] The Chinese medicine compound preparation of the invention is composed of medicines such as trifoliate ganoderma, curcuma zedoaria, astragalus, herba prunellae, thunbergii bulb, raw oyster, thorn of honey locust, centella asiatica, raw atractylodes macrocephala, liquorice and the like. Trifoliate ganoderma and curcuma zedoaria are bitter, purgative, pungent, dispersing, warming and unblocking, can break blood and dissipate blood stasis, eliminate symptoms and dissipate stagnation, promote qi and relieve pain. Trifoliate ganoderma is more inclined to break blood stasis, while curcuma zedoaria is more inclined to break qi, and the two medicines are used in a complementary manner, and the effects of breaking blood stasis and dissipating stagnation are very good; herba prunellae, thunbergii bulb, raw oyster and thorn of honey locust can soften and dissipate stagnation; centella asiatica is bitter and pungent, cold in nature, can detoxify and reduce swelling, and can also activate blood circulation; most of the medicines in the prescription are bitter and cold in nature, can injure the stomach, so astragalus is used to invigorate qi and strengthen the spleen, support toxins and discharge pus, atractylodes macrocephala is warm in nature, can strengthen the spleen and dry dampness, and protect stomach qi, and liquorice is used to harmonize the medicines, and the whole prescription is compatible, can promote blood circulation and dissipate blood stasis, soften and dissipate stagnation, and is good at treating keloids caused by qi stagnation and blood stasis.

[0022] The research found that the Chinese medicine compound preparation for treating keloid of the present invention has significant clinical and animal experimental effects on the treatment of keloid model. The Chinese medicine compound preparation of the present invention is a Chinese medicine preparation that can be taken orally, which is different from the existing treatment drugs for keloid, which are usually external preparations. The Chinese medicine compound preparation of the present invention reduces the expression of tissue TGF-β1, inhibits the proliferation of fibroblasts and the synthesis of extracellular matrix, and inhibits the proliferation of keloids by promoting blood circulation and removing blood stasis, softening and dispersing nodules.

[0023] The Chinese medicinal compound preparation for treating keloid and the preparation method thereof of the present invention will be further described below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The figure shows the healing of the incision at the site of keloid implantation after surgery in mice. Three weeks after surgery, keloid tissue was removed from the subcutaneous tissue of the back of BALB / c nude mice, and it was found that the scar tissue was surrounded by connective tissue and obvious capillaries were visible on the surface of the keloid tissue, proving that the tissue survived well under the skin of the nude mice.

[0025] Figure 2 The effect of the Chinese herbal compound preparation for treating keloid on the quality of keloid. Comparison of the difference in the quality of keloid in each group before and after treatment; (n=5, Chinese herbal compound preparation vs control group, **P<0.01, Chinese herbal compound preparation group vs Centella asiatica tablets group, #P<0.05).

[0026] Figure 3 Effects of a Chinese herbal compound preparation for the treatment of keloid on the histology and collagen morphology of keloid (Day 28, HE, ×400, A: control group; B: Centella asiatica tablets group; C: Chinese herbal compound preparation group. Masson staining, ×400, D: control group; E: Centella asiatica tablets group; F: Chinese herbal compound preparation group).

[0027] Figure 4 To investigate the effect of a traditional Chinese medicine compound preparation for the treatment of keloid on the expression of TGF-β1 in keloid tissue.

[0028] Figure 5 These are photos of the treatment effects of Clinical Case 3. DETAILED DESCRIPTION

[0029] Example 1 Decoction Preparation

[0030] Take 6g of Trigonum multiflorum, 6g of Curcuma zedoaria, 9g of Astragalus, 9g of Prunella vulgaris, 9g of Fritillaria thunbergii, 15g of raw oyster, 9g of Gleditsia sinensis, 18g of Centella asiatica, 9g of raw Atractylodes macrocephala, and 9g of Licorice, mix them, soak them in water for 20 to 40 minutes, boil them over high heat, then change to low heat, continue to boil over low heat for 40 to 60 minutes, filter to obtain the medicinal liquid and the medicinal residue; continue to boil the medicinal residue over high heat until it boils, then change to low heat, continue to boil over low heat for 20 to 40 minutes, filter again to obtain the secondary medicinal liquid; combine the medicinal liquids obtained twice and concentrate them. The concentration of the concentrated crude drug is 1.65g / mL.

[0031] Example 2 Oral Liquid Preparation

[0032] Take 6g of Trigonum multiflorum, 6g of Curcuma zedoaria, 9g of Astragalus, 9g of Prunella vulgaris, 9g of Fritillaria thunbergii, 15g of raw oyster, 9g of Gleditsia sinensis, 18g of Centella asiatica, 9g of raw Atractylodes macrocephala, and 9g of Licorice, boil them in boiling water for 10 minutes, take them out, stew them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, and after reduced pressure concentration, vacuum dry the extract (conditions: temperature is 70°C, pressure is 0.08MPa) to a relative density of 1.05±0.02 (temperature is 60°C), high-speed centrifuge to remove impurities and purify, cool and stand for 24 hours, take the supernatant, filter the pulp cake, concentrate it to a relative density of 1.15-1.20 (temperature is 60°C), package it, and sterilize it.

[0033] Example 3 Capsule Preparation

[0034] Take 6g of Trigonum multiflorum, 6g of Curcuma zedoaria, 9g of Astragalus membranaceus, 9g of Prunella vulgaris, 9g of Fritillaria thunbergii, 15g of raw oyster, 9g of Gleditsia sinensis, 18g of Centella asiatica, 9g of raw Atractylodes macrocephala, and 9g of Licorice, boil them in boiling water for 10 minutes, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature is 60°C, pressure is 0.08MPa), grind it into fine powder, add ethanol to granulate, dry it, and put it into capsules to obtain.

[0035] Example 4 Granule Preparation

[0036] Take 6g of Trigonum multiflorum, 6g of Curcuma zedoaria, 9g of Astragalus, 9g of Prunella vulgaris, 9g of Fritillaria thunbergii, 15g of raw oyster, 9g of Gleditsia sinensis, 18g of Centella asiatica, 9g of raw Atractylodes macrocephala, and 9g of Licorice, boil them in boiling water for 10 minutes, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, and after reduced pressure concentration, vacuum dry the extract (temperature is 70°C, pressure is 0.08MPa) to a relative density of 1.05±0.02 (temperature is 60°C), high-speed centrifuge to remove impurities and purify, cool and stand for 24 hours, take the supernatant, filter the pulp cake, concentrate it to a relative density of 1.15-1.20 (temperature is 60°C), spray dry, dry granulate, and package it with aluminum-plastic composite film to obtain.

[0037] Example 5 Tablet Preparation

[0038] Take 6g of Trigonum multiflorum, 6g of Curcuma zedoaria, 9g of Astragalus membranaceus, 9g of Prunella vulgaris, 9g of Fritillaria thunbergii, 15g of raw oyster, 9g of Gleditsia sinensis, 18g of Centella asiatica, 9g of raw Atractylodes macrocephala, and 9g of Licorice, boil them in boiling water for 10 minutes, take them out, simmer them thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature is 60°C, pressure is 0.08MPa), grind it into fine powder, add starch, granulate it, and press it into tablets.

[0039] Example 6 Preparation of honey pills

[0040] Take 6g of Trigonum multiflorum, 6g of Curcuma zedoaria, 9g of Astragalus, 9g of Prunella vulgaris, 9g of Fritillaria thunbergii, 15g of raw oyster, 9g of Gleditsia sinensis, 18g of Centella asiatica, 9g of raw Atractylodes macrocephala, and 9g of Licorice, boil them in boiling water for 10 minutes, take them out, simmer thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour. Combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature is 60°C, pressure is 0.08MPa), grind into fine powder, add refined honey, stir the honey and the powder in a ratio of 1.5:1, and prepare honey pills.

[0041] In order to verify the activity of the above-mentioned Chinese herbal compound preparation, the Chinese herbal compound composition in the form of a concentrated decoction was used to act on mice.

[0042] Keloid nude mouse model and administration method: refer to the method of Fanous A et al. (Fanous A, Bezdjian A, Caglar D, et al. Treatment of Keloid Scars with Botulinum Toxin Type A versus Triamcinolone in an Athymic Nude Mouse Model [J]. Plast Reconstr Surg, 2019, 143 (3): 760-767.). 6-8 week old BALB / c healthy female nude mice, weighing 12-16 g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Under aseptic operation, the human chest keloid removed by surgery was cut into 5mm×5mm×5mm tissue blocks, and 0.1% pentobarbital was used for intraperitoneal anesthesia, with a dosage of 60-70mg / kg. After the anesthesia effect was confirmed, an incision of about 1cm was made on the scapula of nude mice, and the human keloid tissue blocks were transplanted into the subcutaneous part of the back of nude mice. The operation should be completed within 2 hours after the scar tissue was removed from the body. About 14 days later, a living keloid animal model was made. The drug was administered 14 days after modeling, twice a day, 0.2mL each time. The control group was given an equal amount of purified water for 4 consecutive weeks. After all experiments were completed, the standard operating procedures (SOP) for killing experimental animals (rats and rabbits) were strictly followed, and the keloid tissue was taken from mice 4 weeks after administration. The tissue mass was weighed with a precision electronic scale, and the tissue was fixed, dehydrated, paraffin-embedded, and sliced.

[0043] The experimental results showed that all mice in each group survived and lived in good condition, with normal diet, defecation, weight gain and activity. The keloid implanted incision healed, the keloid tissue was surrounded by connective tissue, and obvious capillaries were visible on the surface of the keloid tissue, proving that the tissue survived well under the skin of nude mice. Figure 1 .

[0044] The weight of keloids in each group of mice was weighed before and after treatment, and the results showed that there was no statistical difference in the weight of keloids in each group of mice before treatment (P>0.05); after intervention, compared with the control group, the weight difference of keloids in the Centella asiatica tablet group increased, but there was no statistical difference (P>0.05); compared with the control group, the weight difference of keloids in the Chinese herbal compound preparation for treating keloids group increased, with a statistical difference (P<0.05); compared with the Centella asiatica tablet group, the weight difference of keloids in the Chinese herbal compound preparation for treating keloids group increased, with a statistical difference (P<0.05), see Figure 2 .

[0045] HE staining results showed that 28 days after treatment, a large number of fibroblasts and scattered inflammatory cell infiltration were found in the keloids of the control group, while the number of fibroblasts in the Centella asiatica tablet group and the Chinese herbal compound preparation for treating keloids was less, and the inflammatory cell infiltration was not obvious. Figure 3 A, B, C.

[0046] Masson staining showed that 28 days after treatment, the collagen fibers in the control group were thick and dense, while those in the Centella asiatica tablets group and the Chinese herbal compound preparation for treating keloids were relatively small and loose. Figure 3 D, E, F.

[0047] Immunohistochemical staining was used to detect the expression of TGF-β1 in each group of keloids. The results showed that 28 days after treatment, compared with the control group, the expression of TGF-β1 in the Centella asiatica tablet group was reduced, with a statistically significant difference (P<0.05). Compared with the control group, the expression of TGF-β1 in the Chinese herbal compound preparation for treating keloids was reduced, with a statistically significant difference (P<0.05). Compared with the Centella asiatica tablet group, the expression of TGF-β1 in the Chinese herbal compound preparation for treating keloids was reduced, but there was no statistical difference (P>0.05). Figure 4 And Table 1.

[0048] Table 1 Effects of Chinese herbal compound preparations on TGF-β1 expression in keloids ( n=3)

[0049]

[0050] Note: vs control group, *P<0.05.

[0051] Early clinical observations showed that the Chinese herbal compound preparation of the present invention has a significant therapeutic effect on the treatment of keloids. Animal experimental results also showed that the Chinese herbal compound preparation can reduce the mass of keloids in a BALB / c nude mouse model of keloids, reduce the secretion of TGF-β1 in scar tissue of the nude mouse model, inhibit the proliferation of fibroblasts and the synthesis of extracellular matrix, thereby inhibiting the growth of keloids.

[0052] Clinical Case 1

[0053] Tian, ​​female, 69 years old, had red hyperplastic plaques on the anterior chest for more than 10 years. The patient had hyperplasia on the wound after heart surgery more than 10 years ago. She had been treated with injections, but the effect was poor, accompanied by obvious pain and itching. Dermatological examination: A dark red hyperplastic plaque about 15 cm long can be seen on the anterior chest, with the edges growing outward like crab feet. Diagnosis: keloid. The drug in Example 1 was taken orally twice a day. On April 20, 2022, the scar was slightly flatter than before, the color became light red, and the itching and pain symptoms were alleviated.

[0054] Clinical Case 2

[0055] Tang, female, 30 years old, from Beijing. Red hyperplastic plaques on the left ribs for 3 years. The patient had local red hyperplastic plaques after herpes zoster on the left ribs 3 years ago. The plaques continued to proliferate. She visited the doctor many times and was told that she needed drug injection or surgical treatment. The patient was afraid of pain and fear of postoperative recurrence, so she was unwilling to be injected and surgically treated. The keloid continued to proliferate, accompanied by obvious pain and itching. There was no special history. Skin examination: dark red hyperplastic plaques with band-like distribution and scattered in the left ribs were seen. Diagnosis: keloid, the drug in Example 1 was taken orally twice a day, and the scar was obviously flat, the color faded, and the itching and pain symptoms basically disappeared.

[0056] Clinical Case 3

[0057] Wang, female, 40 years old, from Henan. She has had hyperplastic plaques on her back and upper arms for more than 10 years. More than 10 years ago, the patient developed a brown-black papule on the right back and left upper arm. In the past 8 years, the lesions have gradually increased to the size of an egg, with occasional itching. In the past year, the lesions have occasionally had needle-like pain. There is no special past history. Dermatological examination: A dark red plaque of about 5cm×3.5cm in size can be seen on the right back, with medium hardness. A dark red oval plaque of about 7cm×4cm in size can be seen on the left upper arm, with medium hardness. Diagnosis: Keloid, the patient was given the drug in Example 1 orally twice a day. After 4 months, the lesions were significantly shrunk, the texture softened, and the pain disappeared (see Figure 5 ).

[0058] Clinical Case 4

[0059] Liu, female, 35 years old, from Sichuan. She had hyperplastic plaques on the wound after ear piercing on her right ear for more than 10 years, and hyperplastic plaques on the abdomen after cesarean section for 6 years. The patient had a red hyperplastic plaque on the earlobe after ear piercing more than 10 years ago. She had recurrence after surgical resection and radiotherapy. The wound after cesarean section 6 years ago was hyperplastic and continued to grow. Both plaques were accompanied by obvious pain and itching, which seriously affected her appearance and sleep. The patient refused injections and surgical treatment because of fear of pain and postoperative recurrence. Diagnosis: keloid, intermittent external application of halometasone cream, oral administration of the drug in Example 1 twice a day, after 6 months, the abdominal scar was obviously flat, the color became lighter, and the volume of the earlobe keloid was also significantly reduced.

[0060] The embodiments described above are merely descriptions of preferred implementation modes of the present invention and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicinal compound preparation for treating keloid, characterized in that: The raw materials are composed of Trigonosciadium japonicum, Curcuma zedoaria, Astragalus membranaceus, Prunella vulgaris, Fritillaria thunbergii, raw oyster, Gleditsia sinensis, Centella asiatica, raw Atractylodes macrocephala, and Licorice; The dosage of each component of the raw material medicine is 5-10 parts of Trigonosciadium japonicum, 6-9 parts of Curcuma zedoaria, 9-30 parts of Astragalus membranaceus, 9-15 parts of Prunella vulgaris, 5-10 parts of Fritillaria thunbergii, 9-30 parts of raw oyster, 3-10 parts of Gleditsia sinensis, 15-30 parts of Centella asiatica, 6-12 parts of raw Atractylodes macrocephala, and 2-10 parts of Licorice.

2. The Chinese medicinal compound preparation for treating keloid according to claim 1, characterized in that: The dosage of each component of the raw material medicine is 6 parts of Trigonosciadium japonicum, 6 parts of Curcuma zedoaria, 9 parts of Astragalus membranaceus, 9 parts of Prunella vulgaris, 9 parts of Fritillaria thunbergii, 15 parts of raw oyster, 9 parts of Gleditsia sinensis, 18 parts of Centella asiatica, 9 parts of raw Atractylodes macrocephala, and 9 parts of Licorice.

3. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 1 or 2, characterized in that: After mixing the raw materials, soak them in water for 20 to 40 minutes, boil over high heat, then switch to low heat, and continue to boil over low heat for 40 to 60 minutes, and filter to obtain the medicinal liquid and medicinal residue; continue to boil the medicinal residue over high heat until it boils, then switch to low heat, and continue to boil over low heat for 20 to 40 minutes, and filter again to obtain the secondary medicinal liquid; the two obtained medicinal liquids are combined and concentrated.

4. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 3, characterized in that: The concentration of the concentrated crude drug was 1.65 g / mL.

5. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 1 or 2, characterized in that: Boil the raw material in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrate, recover the ethanol under reduced pressure, and concentrate the extract under reduced pressure and vacuum dry to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, package it, and sterilize it to obtain the oral solution.

6. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 1 or 2, characterized in that: Boil the raw material drug in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, grind it into fine powder, add ethanol to granulate, dry, and put it into capsules to obtain capsules.

7. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 1 or 2, characterized in that: Boil the raw material in boiling water for 10 minutes, take it out, stew it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, and concentrate the extract under reduced pressure and vacuum dry to a relative density of 1.05±0.02, remove impurities and purify it by high-speed centrifugation, cool and stand for 24 hours, take the supernatant, filter it with pulp cake, concentrate it to a relative density of 1.15-1.20, spray dry, dry granulate, and package it with aluminum-plastic composite film to obtain granules.

8. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 1 or 2, characterized in that: Boil the raw material drug in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add starch, granulate, and press into tablets to obtain tablets.

9. The method for preparing the Chinese medicinal compound preparation for treating keloid according to claim 1 or 2, characterized in that: Boil the raw material medicine in boiling water for 10 minutes, take it out, simmer it thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, each time for 1 hour, combine the filtrate, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, crush it into fine powder, add refined honey, stir the honey and powder in a ratio of 1.5:1, and prepare honey pills.

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