A liquid medicine anti-bubble filling system and method

Abstract

The present invention discloses a liquid medicine anti-bubble filling system, which includes a buffer tank and a piston. The piston slides in the buffer tank, dividing the interior of the buffer tank into an upper space and a lower space. The top of the buffer tank is provided with an air inlet and an air extraction port, and the bottom is provided with a liquid inlet and outlet. The center of the piston is connected with an air extraction channel, and pressure sensors are provided at both the top and the bottom of the buffer tank. Also disclosed is a liquid medicine anti-bubble filling method, which includes the steps of: before liquid inlet, during liquid inlet, and after liquid inlet, simultaneously evacuating the upper space and the lower space of the buffer tank through the air extraction port and the air extraction channel to reach a set vacuum degree, feeding liquid through the liquid inlet and outlet until reaching the set liquid level; introducing air through the air inlet to make the liquid inlet and outlet discharge liquid at a constant pressure. This liquid medicine anti-bubble filling system and method can well control the pressure difference between the upper space and the lower space in the buffer tank, avoid the piston floating and affecting the volume of the filled liquid, and can make the liquid inlet and outlet discharge liquid at a constant pressure, improving the filling accuracy after liquid discharge.

Description

Technical Field

[0001] The present invention relates to the technical field of food and pharmaceutical packaging machinery and equipment, and particularly to a liquid medicine anti-bubble filling system and method. Background Art

[0002] At present, for the filling of high-viscosity liquid medicines, it is generally necessary to evacuate the liquid medicine to remove bubbles and then pressurize the filling to achieve an ideal filling effect (poor fluidity of the liquid medicine). After the liquid medicine is prepared in the liquid preparation room, it is in a different room from the filling machine and cannot be directly fed to the filling machine for filling. Therefore, an intermediate transfer liquid medicine buffer system is required, which can simultaneously meet the functions of evacuating bubbles, pressurizing filling, and aseptic transfer (the problem of liquid medicine residue needs to be fully considered), and is used to transfer the liquid medicine and assist in the stable and high-precision filling of the liquid medicine.

[0003] An existing liquid medicine buffer system, such as a vacuum centrifugal defoaming container with the application number 202211420410.2, discloses a barrel body, in which a piston is slidably arranged. The barrel body is connected to a second joint and a third joint. An isolation valve is provided on the piston. The second joint is arranged above the piston, and the third joint is arranged below the piston. The isolation valve controls its own on-off through the pressure difference between the upper and lower sides of the piston. The second joint exhausts air by evacuating, and the second joint is externally connected to compressed air to drive the piston to move downward. A filter is provided in the second joint. Through the second joint 7, the upper cavity of the barrel body can be evacuated. At this time, the pressure in the lower cavity is greater than that in the upper cavity, and the isolation valve automatically opens. The air in the lower cavity enters the upper cavity through the isolation valve and then is discharged through the second joint. External air enters the upper cavity. At this time, the pressure in the upper cavity is greater than that in the lower cavity, and the isolation valve automatically closes. The second joint is externally connected to compressed air, and the pressure in the upper cavity continues to increase, driving the piston to move downward. The piston drives the liquid medicine in the lower cavity to be discharged from the third joint. The liquid medicine at the third joint can directly enter the filling system through a pipeline without secondary transfer to ensure the aseptic transfer of the liquid medicine. The vacuum centrifugal defoaming container has the following deficiencies:

[0004] 1) The upper and lower cavities in the barrel body are connected by an isolation valve. When evacuating, it is difficult to evacuate the upper and lower cavities simultaneously (generally, the upper cavity is evacuated first), and it is difficult to control the pressure difference between the upper and lower cavities. The piston is prone to floating, affecting the volume of the filling liquid;

[0005] 2) It is difficult to detect the liquid level position inside the barrel body;

[0006] 3) It is difficult to achieve constant pressure filling and smooth liquid discharge;

[0007] 4) The barrel body and the barrel cover are connected by a hoop, and it is difficult to ensure the coaxiality of the installation;

[0008] 5) The bottom of the barrel body is an integral closed structure, which is not convenient for cleaning. Summary of the Invention

[0009] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a liquid medicine anti-bubble filling system and method that can well control the pressure difference between the upper space and the lower space in the buffer tank, avoid the piston from floating and affecting the volume of the filled liquid, enable the liquid inlet and outlet to discharge liquid at a constant pressure, and improve the filling accuracy after liquid discharge.

[0010] To solve the above technical problems, the present invention adopts the following technical solutions:

[0011] A liquid medicine anti-bubble filling system includes a buffer tank and a piston. The piston is slidably disposed in the buffer tank, dividing the buffer tank into an upper space and a lower space. The top of the buffer tank is provided with an air inlet and an air extraction port, and the bottom is provided with a liquid inlet and outlet. The air extraction port is used to extract air from the upper space of the buffer tank. The center of the piston is connected with an air extraction channel, and the air extraction channel is used to extract air from the lower space of the buffer tank. Pressure sensors are provided at both the top and the bottom of the buffer tank.

[0012] As a further improvement of the above technical solution:

[0013] A lifting rod is provided at the center of the top of the piston. The lifting rod passes through the top of the buffer tank, and the air extraction channel runs through the lifting rod.

[0014] A locking mechanism for locking the lifting rod is provided on the buffer tank.

[0015] A guide sleeve is provided at the top of the buffer tank. The lifting rod is slidably disposed in the guide sleeve, and the locking mechanism is disposed on the guide sleeve.

[0016] The locking mechanism includes a locking screw. The locking screw passes through the side wall of the guide sleeve and is threadedly connected to the side wall of the guide sleeve.

[0017] Scale marks are provided on the lifting rod, and a weighing sensor is provided on the buffer tank.

[0018] The air extraction port is connected with an air extraction pipe. An air extraction valve, a filter, and a vacuum pump are provided on the air extraction pipe. An air inlet pipe is provided at the air inlet. An air inlet valve and a proportional regulating valve are provided on the air inlet pipe. The liquid inlet and outlet are connected with a liquid inlet pipe and a liquid outlet pipe. A liquid inlet valve is provided on the liquid inlet pipe. A liquid outlet valve is provided on the liquid outlet pipe. The liquid outlet pipe is connected to a liquid distributor at the filling station, and the liquid distributor is connected with a filling needle.

[0019] The buffer tank includes a tank body, a top cover, and a bottom cover. The bottom cover is detachably disposed at the bottom of the tank body, the top cover is clamped on the top of the tank body, the piston is slidably disposed in the tank body, the air inlet and the air extraction port are both provided on the top cover, the liquid inlet and outlet are provided on the bottom cover, and the pressure sensors are respectively disposed on the top cover and the bottom cover.

[0020] The liquid medicine anti-bubble filling system further includes a moving rack, and the buffer tank is arranged on the moving rack.

[0021] A liquid medicine anti-bubble filling method, which is carried out by using the above-mentioned liquid medicine anti-bubble filling system, includes the following steps:

[0022] S1. Before, during, and after the liquid inlet, the upper space and the lower space of the buffer tank are simultaneously evacuated through the air extraction port and the air extraction channel to reach the set vacuum degree, and the liquid is inlet through the liquid inlet and outlet until the set liquid level is reached;

[0023] S2. Air is introduced through the air inlet to make the liquid inlet and outlet discharge liquid at a constant pressure for filling.

[0024] Compared with the prior art, the advantages of the present invention are as follows:

[0025] In the liquid medicine anti-bubble filling system of the present invention, since the upper space and the lower space of the buffer tank can be simultaneously evacuated through the air extraction port and the air extraction channel respectively by the piston, the pressure difference between the upper space and the lower space in the buffer tank is well controlled, and the piston floating is avoided, which affects the capacity of the filling liquid (the empty volume of the lower space before pressing). Moreover, pressure sensors are arranged at the top and bottom of the buffer tank. Through the feedback of the pressure sensors, the air inlet situation of the air inlet can be well controlled, so that the liquid inlet and outlet discharge liquid at a constant pressure, and the filling accuracy after liquid discharge is improved.

[0026] In the liquid medicine anti-bubble filling method of the present invention, before, during, and after the liquid inlet, the upper space and the lower space of the buffer tank are simultaneously evacuated through the air extraction port and the air extraction channel, so that the pressure difference between the upper space and the lower space in the buffer tank is well controlled, and the piston floating is avoided, which affects the capacity of the filling liquid (the empty volume of the lower space before pressing). Moreover, air is introduced through the air inlet to make the liquid inlet and outlet discharge liquid at a constant pressure, and the filling accuracy after liquid discharge can be improved. Description of the Drawings

[0027] Figure 1 is a perspective structural schematic diagram of the first perspective of the liquid medicine anti-bubble filling system of the present invention.

[0028] Figure 2 is a perspective structural schematic diagram of the second perspective of the liquid medicine anti-bubble filling system of the present invention.

[0029] Figure 3 is a main sectional structural schematic diagram of the liquid medicine anti-bubble filling system of the present invention.

[0030] Figure 4 is Figure 3 the enlarged view of part A in

[0031] Figure 5 is a structural schematic diagram of another embodiment of the liquid medicine anti-bubble filling system of the present invention.

[0032] Figure 6 It is a process diagram of the method for preventing air bubbles in the liquid medicine filling of the present invention. In the figure, a1 is the state diagram during vacuum pumping, a3 is the state diagram during liquid inlet, a3 is the state diagram during liquid outlet filling, and a4 is the state diagram after liquid outlet is completed.

[0033] Each label in the figure represents:

[0034] 1. Buffer tank; 10. Weighing sensor; 11. Tank body; 12. Top cover; 13. Bottom cover; 14. Moving frame; 2. Piston; 21. Lifting rod; 3. Air inlet; 31. Air inlet pipe; 32. Air inlet valve; 4. Air extraction port; 41. Air extraction pipe; 42. Air extraction valve; 43. Filter; 5. Liquid inlet and outlet; 51. Liquid inlet pipe; 52. Liquid outlet pipe; 53. Liquid inlet valve; 54. Liquid outlet valve; 6. Air extraction channel; 7. Pressure sensor; 8. Locking mechanism; 9. Guide sleeve. Specific embodiments

[0035] The following will further elaborate on the present invention in detail with reference to the specification drawings and specific embodiments.

[0036] In the description of the present application, it should be understood that the orientation or positional relationship indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present application.

[0037] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present application, "a plurality" means two or more, unless otherwise specifically defined.

[0038] In the present application, unless otherwise clearly specified and limited, the terms "assembly", "connected", "connected to", "fixed", etc. should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the internal communication of two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0039] Practical example one:

[0040] Figures 1 to 4 An embodiment of the anti-bubble filling system for the liquid medicine of the present invention is shown. The anti-bubble filling system for the liquid medicine includes a buffer tank 1 and a piston 2. The piston 2 is slidably disposed in the buffer tank 1, dividing the interior of the buffer tank 1 into an upper space and a lower space. An air inlet 3 and an air extraction port 4 are provided at the top of the buffer tank 1, and a liquid inlet and outlet 5 is provided at the bottom. The air extraction port 4 is used to extract air from the upper space of the buffer tank 1. A central connection of the piston 2 is provided with an air extraction channel 6, and the air extraction channel 6 is used to extract air from the lower space of the buffer tank 1. Pressure sensors 7 are provided at both the top and the bottom of the buffer tank 1.

[0041] During use: Before, during, and after liquid inlet, the upper space and the lower space of the buffer tank 1 are simultaneously evacuated through the air extraction port 4 and the air extraction channel 6 until the set vacuum degree is reached, and liquid is inlet through the liquid inlet and outlet 5 until the set liquid level is reached; air is inlet through the air inlet 3 to make the liquid outlet at the liquid inlet and outlet 5 at a constant pressure.

[0042] Since the upper space and the lower space of the buffer tank 1 separated by the piston 2 can be simultaneously evacuated through the air extraction port 4 and the air extraction channel 6 respectively, the pressure difference between the upper space and the lower space in the buffer tank 1 is well controlled, avoiding the floating of the piston 2 and affecting the capacity of the filled liquid (the empty volume of the lower space before pressing down). Moreover, pressure sensors 7 are provided at both the top and the bottom of the buffer tank 1. Through the feedback of the pressure sensors 7, the air inlet situation of the air inlet 3 can be well controlled, making the liquid outlet at the liquid inlet and outlet 5 at a constant pressure and improving the filling accuracy after liquid outlet.

[0043] Further, as Figures 1 to 3 shown, in this embodiment, a lifting rod 21 is provided at the center of the top of the piston 2. The lifting rod 21 passes through the top of the buffer tank 1, and the air extraction channel 6 runs through the lifting rod 21. The lifting rod 21 is provided at the center of the top of the piston 2. On the one hand, when evacuating, the air flow flows out from the center of the piston 2, avoiding the influence of the air flow on multiple parts of the piston 2; on the other hand, the lifting rod 21 is always above the lower space of the buffer tank 1, which has no adverse effect on the liquid medicine in the lower space of the buffer tank 1 and has no adverse effect on the lifting movement of the piston 2.

[0044] Further, as Figure 3 shown, in this embodiment, a locking mechanism 8 for locking the lifting rod 21 is provided on the buffer tank 1. The locking mechanism 8 is used to lock the lifting rod 21, mainly for the pre-assembly stage and the preparation stage to prevent the piston 2 from falling down due to gravity or abnormal pressure difference, injuring people or disrupting the process flow.

[0045] Furthermore, in this embodiment, a guide sleeve 9 is provided at the top of the buffer tank 1. The lifting rod 21 is slidably disposed in the guide sleeve 9, and the locking mechanism 8 is disposed on the guide sleeve 9. The guide sleeve 9 guides the lifting movement of the lifting rod 21 and improves the stability of the movement of the piston 2 at the same time.

[0046] Furthermore, in this embodiment, the locking mechanism 8 includes a locking screw which is inserted through the side wall of the guide sleeve 9 and is threadedly connected to the side wall of the guide sleeve 9. When the lifting rod 21 is at the designated high position, tightening the locking screw can lock the lifting rod 21. The structure is simple and the operation is convenient.

[0047] Furthermore, in this embodiment, a scale mark is provided on the lifting rod 21, and a weighing sensor 10 is provided on the buffer tank 1. The lifting amount of the lifting rod 21 can be observed through the scale mark to detect the liquid level position in the buffer tank 1, and to reflect the buffer amount and the filling amount. The weighing sensor 10 is used to measure the weight of the buffer tank 1. By comparing the weights before and after, the buffer amount (reflecting the liquid level height) and the filling amount of the buffer tank 1 can be measured. Through the dual detection of the scale mark and the weighing sensor 10, it is convenient to detect the liquid level position in the buffer tank 1 and ensure the accuracy of the buffer amount and the filling amount of the buffer tank 1.

[0048] Furthermore, in this embodiment, the air extraction port 4 is connected to an air extraction pipe 41. An air extraction valve 42, a filter 43 and a vacuum pump are provided on the air extraction pipe 41. The air inlet 3 is provided with an air inlet pipe 31. An air inlet valve 32 and a proportional regulating valve are provided on the air inlet pipe 31. The liquid inlet and outlet 5 is connected to a liquid inlet pipe 51 and a liquid outlet pipe 52. A liquid inlet valve 53 is provided on the liquid inlet pipe 51. A liquid outlet valve 54 is provided on the liquid outlet pipe 52. The liquid outlet pipe 52 is connected to a liquid distributor at the filling station, and the liquid distributor is connected to a filling needle. The start and end of air extraction are realized by the on-off operation of the air extraction valve 42 and the vacuum pump. The start and end of air intake are realized by the on-off operation of the air inlet valve 32. The pressure sensor 7 at the bottom of the buffer tank 1 is used to detect the liquid medicine pressure at the liquid inlet and outlet 5 (the position closest to the actual filling pump), and feed it back to the proportional regulating valve to ensure that the liquid pressure at the liquid outlet end tends to be a constant value.

[0049] Furthermore, as Figures 1 to 3As shown in the figure, in this embodiment, the buffer tank 1 includes a tank body 11, a top cover 12 and a bottom cover 13. The bottom cover 13 is detachably arranged at the bottom of the tank body 11, the top cover 12 is clamped on the top of the tank body 11, the piston 2 slides in the tank body 11, the air inlet 3 and the air extraction port 4 are both arranged on the top cover 12, and the liquid inlet and outlet 5 is arranged on the bottom cover 13. The pressure sensors 7 are respectively arranged on the top cover 12 and the bottom cover 13. The buffer tank 1 is detachably assembled by three split parts, namely the tank body 11, the top cover 12 and the bottom cover 13, which is convenient for disassembly and cleaning. Moreover, the top cover 12 is clamped on the top of the tank body 11 to ensure the coaxiality of the piston 2 and the tank body 11 and prevent the piston 2 from getting stuck during pressurized filling. Preferably, a convex ring and a concave ring are respectively arranged on the opposite surfaces of the top cover 12 and the tank body 11, and they are clamped through the convex ring and the concave ring.

[0050] Embodiment Two:

[0051] Figure 5 Another embodiment of the liquid medicine anti-bubble filling system of the present invention is shown. The structure of this liquid medicine anti-bubble filling system is basically the same as that of Embodiment One, except that: the liquid medicine anti-bubble filling system further includes a moving frame 14, and the buffer tank 1 is arranged on the moving frame 14. The buffer tank 1 is arranged on the moving frame 14, which is convenient for position adjustment.

[0052] Embodiment Three:

[0053] Figure 6 An embodiment of the liquid medicine anti-bubble filling method of the present invention is shown. The liquid medicine anti-bubble filling method of this embodiment is carried out by using the liquid medicine anti-bubble filling system of Embodiment One or Embodiment Two, and includes the following steps:

[0054] S1. Before liquid inlet, during liquid inlet and after liquid inlet, the upper space and the lower space of the buffer tank 1 are simultaneously evacuated through the air extraction port 4 and the air extraction channel 6 (as shown by a1 in the figure), until the set vacuum degree is reached, and then liquid is inlet through the liquid inlet and outlet 5 (as shown by a2 in the figure) until the set liquid level is reached; Figure 6 in the figure), and liquid is inlet through the liquid inlet and outlet 5 (as shown by a2 Figure 6 in the figure) until the set liquid level is reached;

[0055] S2. Air is inlet through the air inlet 3 (as shown by a3 Figure 6 in the figure), so that the liquid inlet and outlet 5 discharges liquid at a constant pressure for filling. Until the liquid discharge is completed and there is no liquid medicine in the buffer tank 1 (as shown by a4 Figure 6 in the figure).

[0056] Before liquid inlet, during liquid inlet and after liquid inlet, the upper space and the lower space of the buffer tank 1 are simultaneously evacuated through the air extraction port 4 and the air extraction channel 6, which well controls the pressure difference between the upper space and the lower space in the buffer tank 1 and avoids the piston 2 from floating and affecting the volume of the filled liquid (the empty volume of the lower space before downward pressure). Moreover, by inletting air through the air inlet 3, the liquid inlet and outlet 5 discharges liquid at a constant pressure, which can improve the filling accuracy after liquid discharge.

[0057] Although the present invention has been disclosed above in its preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can, without departing from the scope of the technical solution of the present invention, make many possible changes and modifications to the technical solution of the present invention by using the technical content disclosed above, or modify it into equivalent embodiments with equivalent changes. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention shall fall within the scope of protection of the technical solution of the present invention.

Claims

1. A liquid medicine anti-bubble filling system, characterized in that: It includes a buffer tank (1) and a piston (2). The piston (2) is slidably arranged in the buffer tank (1), dividing the interior of the buffer tank (1) into an upper space and a lower space. The top of the buffer tank (1) is provided with an air inlet (3) and an air extraction port (4), and the bottom is provided with a liquid inlet and outlet (5). The air extraction port (4) is used to extract air from the upper space of the buffer tank (1). The center of the piston (2) is connected with an air extraction channel (6), and the air extraction channel (6) is used to extract air from the lower space of the buffer tank (1). Pressure sensors (7) are arranged at both the top and the bottom of the buffer tank (1). The top of the piston (2) is provided with a lifting rod (21), and the lifting rod (21) passes through the top of the buffer tank (1). The air extraction channel (6) runs through the lifting rod (21).

2. The liquid medicine anti-bubble filling system according to claim 1, characterized in that: The lifting rod (21) is arranged at the center of the top of the piston (2).

3. The liquid medicine anti-bubble filling system according to claim 2, characterized in that: A locking mechanism (8) for locking the lifting rod (21) is arranged on the buffer tank (1).

4. The liquid medicine anti-bubble filling system according to claim 3, wherein: A guide sleeve (9) is arranged at the top of the buffer tank (1). The lifting rod (21) is slidably arranged in the guide sleeve (9), and the locking mechanism (8) is arranged on the guide sleeve (9).

5. The liquid medicine anti-bubble filling system according to claim 4, characterized in that: The locking mechanism (8) includes a locking screw, and the locking screw passes through the side wall of the guide sleeve (9) and is threadedly connected with the side wall of the guide sleeve (9).

6. The liquid medicine anti-bubble filling system according to claim 2, wherein: Scale marks are arranged on the lifting rod (21), and a weighing sensor (10) is arranged on the buffer tank (1).

7. The liquid medicine anti-bubble filling system according to any one of claims 1 to 6, characterized in that: The air extraction port (4) is connected with an air extraction pipe (41). An air extraction valve (42), a filter (43) and a vacuum pump are arranged on the air extraction pipe (41). The air inlet (3) is provided with an air inlet pipe (31). An air inlet valve (32) and a proportional regulating valve are arranged on the air inlet pipe (31). The liquid inlet and outlet (5) are connected with a liquid inlet pipe (51) and a liquid outlet pipe (52). A liquid inlet valve (53) is arranged on the liquid inlet pipe (51). A liquid outlet valve (54) is arranged on the liquid outlet pipe (52). The liquid outlet pipe (52) is connected with a liquid distributor at the filling station, and the liquid distributor is connected with a filling needle.

8. The liquid medicine anti-bubble filling system according to any one of claims 1 to 6, characterized in that: The buffer tank (1) includes a tank body (11), a top cover (12) and a bottom cover (13). The bottom cover (13) is detachably arranged at the bottom of the tank body (11). The top cover (12) is clamped on the top of the tank body (11). The piston (2) is slidably arranged in the tank body (11). Both the air inlet (3) and the air extraction port (4) are arranged on the top cover (12). The liquid inlet and outlet (5) are arranged on the bottom cover (13). The pressure sensors (7) are respectively arranged on the top cover (12) and the bottom cover (13).

9. The liquid medicine anti-bubble filling system according to any one of claims 1 to 6, characterized in that: The liquid medicine anti-bubble filling system further includes a moving frame (14), and the buffer tank (1) is arranged on the moving frame (14).

10. A method for preventing air bubbles in liquid medicine filling, characterized in that, Using the liquid medicine anti-bubble filling system according to any one of claims 1 to 9, it includes the following steps: S₁. Before, during and after liquid inlet, the upper space and the lower space of the buffer tank (1) are simultaneously evacuated through the air extraction port (4) and the air extraction channel (6) until the set vacuum degree is reached, and liquid is introduced through the liquid inlet and outlet (5) until the set liquid level is reached; S2. Introduce air through the air inlet (3) to enable constant-pressure liquid discharge from the liquid inlet / outlet (5) for filling.

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