A method for preparing an oral hydrocolloid dressing

Abstract

The application discloses a preparation method of a hydrocolloid dressing for oral cavity, and relates to the technical field of medical supplies. Baicalin extract and a polyvinyl pyrrolidone solution are mixed to obtain a baicalin extract solution; chitosan fibers, hydroxymethyl cellulose and the baicalin extract solution are mixed to obtain a mixed solution; vacuum degassing: the prepared mixed solution is vacuumized, pressure is maintained, and primary degassing is performed; ultrasonic degassing: the mixed solution after primary degassing is subjected to ultrasonic degassing; static degassing: the solution after ultrasonic degassing is sealed by using a preservative film, and is subjected to secondary degassing at room temperature; a PU film is fixed in a film laying frame, the degassed mixed solution is poured into the film laying frame, and the film laying frame is placed into an air-blowing drying box to solidify and form a protective layer, so that the hydrocolloid dressing is obtained. The hydrocolloid dressing prepared by the method has good adhesion, can be used on a wound for a long time, and can effectively promote the repair of damaged cells and wounds, so that the healing of the wound in the oral cavity is promoted.

Description

Technical Field

[0001] This invention relates to the field of medical supplies technology, specifically to a method for preparing an oral hydrocolloid dressing. Background Technology

[0002] Hydrocolloid dressings are made from natural hydrocolloids (sodium carboxymethyl cellulose, pectin, and animal glue). Hydrocolloids are hydrophilic materials that are soft and moist. They release growth factors, accelerate granulation tissue and new blood vessel proliferation, promote collagen synthesis, create an acidic and moist environment, and have absorption, fixation, and wound hydration functions.

[0003] Most hydrocolloid dressings cannot be applied in the oral cavity due to poor mucosal adhesion and the influence of saliva. Summary of the Invention

[0004] The purpose of this invention is to provide a method for preparing oral hydrocolloid dressings to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A method for preparing an oral hydrocolloid dressing, wherein the preparation steps of the hydrocolloid dressing are as follows:

[0007] S1: Polyvinylpyrrolidone and purified water are mixed to obtain a polyvinylpyrrolidone solution;

[0008] S2: Mix baicalin extract with polyvinylpyrrolidone solution to obtain baicalin extract solution;

[0009] S3: Chitosan fiber, hydroxymethyl cellulose and baicalin extract solution are mixed to obtain a mixture;

[0010] S4: Vacuum degassing: The prepared mixture is vacuumed and pressure is maintained for preliminary degassing;

[0011] S5: Ultrasonic degassing: The mixture after preliminary degassing is degassed by ultrasound;

[0012] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for a second degassing.

[0013] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the drying oven, cure it, and cover it with a protective layer to obtain the hydrocolloid dressing.

[0014] As a preferred embodiment, the specific preparation steps of the hydrocolloid dressing are as follows:

[0015] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:20-1:30, and stir for 20-30 minutes at room temperature and a stirring speed of 400-600 rpm to obtain a polyvinylpyrrolidone solution.

[0016] S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:20-1:30, and stir for 9-12 minutes at room temperature and a stirring speed of 300-600 rpm to obtain the baicalin extract solution.

[0017] S3: By weight, take 10-20 parts of chitosan fiber, 10-20 parts of hydroxymethyl cellulose and 30-50 parts of baicalin extract solution, and place the modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank. Stir at room temperature and at a speed of 1000-1300 rpm for 80-120 minutes to obtain a mixture.

[0018] S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 8-20 minutes to perform preliminary degassing.

[0019] S5: Ultrasonic degassing: After the initial degassing is completed, the mixture is taken out of the vacuum drying oven and the sealed solution is placed in an ultrasonic cleaner for ultrasonic degassing for 9-15 minutes.

[0020] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 20-30 hours to degas a second time.

[0021] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 5-8mm, 75-90℃, 10-20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0022] Preferably, the chitosan fiber in step S3 can also be a modified chitosan fiber.

[0023] Preferably, the modified chitosan fiber is prepared using the following steps:

[0024] Chitosan fiber and deionized water were mixed at a mass ratio of 1:50-1:80 and stirred at 80-100℃ and 800-1000 rpm for 1-2 hours to dissolve. Then, β-cyclodextrin at 2-3 times the mass of chitosan fiber was added and stirred at 30-50℃ and 800-1000 rpm for 20-30 minutes. Subsequently, acetic acid solution at 0.2-0.3 times the mass of chitosan fiber and a mass fraction of 2-3% was added dropwise and stirred at 800-1000 rpm until the solution became white and viscous. Finally, genipin at 1-2% mass fraction and homemade essential oil at 0.02-0.03 times the mass of chitosan fiber were added dropwise. Then, the mixture was stirred at 800-1000 rpm for 3-5 hours and then placed in a 37℃ constant temperature water bath for 12 hours to crosslink until a gel was formed, thus obtaining modified chitosan fiber.

[0025] Preferably, pomegranate peel extract may also be added to the oral hydrocolloid dressing.

[0026] Preferably, the pomegranate peel extract is prepared as follows:

[0027] The dried pomegranate peel is crushed and passed through a 600-800 mesh sieve. The resulting pomegranate peel powder is then mixed with an ethanol solution at a mass ratio of 1:20-1:30 and soaked for 3-5 hours. The mixture is then vacuum filtered at a temperature of 80-90℃ to obtain the supernatant. The supernatant is concentrated by rotary evaporation and then extracted 3-5 times with petroleum ether. After concentration and freeze-drying, the pomegranate peel extract is obtained.

[0028] Preferably, the method for preparing the homemade essential oil is as follows:

[0029] Basil essential oil and a 5-8% (w / w) zein ethanol aqueous solution are placed in a mixing vessel at a volume ratio of 8:1-12:1. Then, 3-5 times the volume of deionized water is added to the basil essential oil mixture. The mixture is stirred and mixed at 1000-1200 rpm for 20-30 minutes, then allowed to stand for 20-30 minutes. The upper suspension is collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture is then stored at a low temperature of 1-4℃ to obtain the homemade essential oil.

[0030] In summary, due to the adoption of the above-mentioned technologies, the beneficial effects of this invention are:

[0031] This invention incorporates modified chitosan fibers, which possess excellent biocompatibility and a morphology similar to extracellular matrix fibers, thus promoting cell adhesion and proliferation. Furthermore, the addition of basil essential oil, which exhibits good antibacterial properties, allows the essential oil to be uniformly embedded within the pores of the hydrogel system. The hydrogen bonding of the hydrogel slows down the release of the essential oil. Simultaneously, the mixing of zein with basil essential oil, through hydrogen bonding between the amino and hydroxyl groups in the zein and the basil essential oil, further slows the release of the essential oil. This allows the product to have a long-lasting effect on wounds, thereby promoting wound healing in the oral cavity.

[0032] Free radicals generated during wound healing can attack and damage proteins in tissues, affecting wound healing. By adding pomegranate peel extract, which is rich in polyphenols and flavonoids, the patch has a good scavenging effect on DPPH free radicals, thus giving the patch good antioxidant activity.

[0033] In the oral cavity, due to the influence of saliva, conventional bandages cannot guarantee good adhesion and are prone to falling off. The addition of baicalin extract enhances adhesion.

[0034] Ordinary bandages have only one function, while hydrocolloid bandages can accelerate granulation tissue formation and promote wound healing.

[0035] The addition of polyvinylpyrrolidone serves to protect the colloid and enhance its hygroscopicity and coagulation properties.

[0036] By combining vacuum degassing, ultrasonic degassing, and static degassing, the dressing layer is more evenly distributed and maintains good conformability. Detailed Implementation

[0037] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely to represent selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] Example 1

[0039] The specific preparation steps of the hydrocolloid dressing are as follows:

[0040] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:30, and stir for 30 minutes at room temperature and a stirring speed of 600 rpm to obtain a polyvinylpyrrolidone solution.

[0041] S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:30, and stir for 12 minutes at room temperature and a stirring speed of 600 rpm to obtain the baicalin extract solution.

[0042] S3: By weight, take 3 parts of pomegranate peel extract, 20 parts of modified chitosan fiber, 20 parts of hydroxymethyl cellulose and 50 parts of baicalin extract solution. Place the pomegranate peel extract, modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank and stir for 120 minutes at room temperature and a stirring speed of 1300 rpm to obtain a mixture.

[0043] S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 20 minutes to perform preliminary degassing.

[0044] S5: Ultrasonic degassing: The mixture after preliminary degassing is taken out of the vacuum drying oven, and the sealed solution is placed in an ultrasonic cleaner for ultrasonic degassing for 15 minutes.

[0045] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 30 hours to degas a second time.

[0046] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 8mm, 90℃, 20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0047] The preparation steps for modified chitosan fibers are as follows:

[0048] Chitosan fiber was mixed with deionized water at a mass ratio of 1:80 and stirred at 100℃ and 1000 rpm for 2 hours to dissolve. Then, β-cyclodextrin with a mass ratio of 3 times that of chitosan fiber was added and stirred at 30℃ and 800 rpm for 20 minutes. Subsequently, acetic acid solution with a mass fraction of 3% and a mass ratio of 0.2 times that of chitosan fiber was added dropwise and stirred at 800 rpm until the solution became white and viscous. Finally, genipin with a mass fraction of 2% and homemade essential oil with a mass ratio of 0.03 times that of chitosan fiber were added dropwise. After stirring at 800 rpm for 3 hours, the mixture was placed in a constant temperature water bath at 37℃ and allowed to crosslink for 12 hours until it became gel-like, thus obtaining modified chitosan fiber.

[0049] The preparation process of pomegranate peel extract is as follows:

[0050] The dried pomegranate peel was crushed and passed through a 600-mesh sieve. The resulting pomegranate peel powder was then mixed with an ethanol solution at a mass ratio of 1:20 and soaked for 3 hours. The mixture was then vacuum filtered at 80°C to obtain the supernatant. The supernatant was concentrated by rotary evaporation and then extracted three times with petroleum ether. After concentration and freeze-drying, the pomegranate peel extract was obtained.

[0051] Preferably, the method for preparing the homemade essential oil is as follows:

[0052] Basil essential oil and an ethanol-water solution of 8% zein (by mass) were placed in a mixing vessel at a volume ratio of 12:1. Then, five times the volume of deionized water was added to the basil essential oil mixture. The mixture was stirred and mixed at 1200 rpm for 30 minutes, then allowed to stand for 30 minutes. The upper suspension was then collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture was then stored at 4°C to obtain the homemade essential oil.

[0053] Example 2

[0054] The specific preparation steps of the hydrocolloid dressing are as follows:

[0055] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:20, and stir for 20 minutes at room temperature and a stirring speed of 400 rpm to obtain a polyvinylpyrrolidone solution.

[0056] S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:20, and stir for 12 minutes at room temperature and a stirring speed of 300 rpm to obtain the baicalin extract solution.

[0057] S3: By weight, take 2 parts of pomegranate peel extract, 10 parts of modified chitosan fiber, 10 parts of hydroxymethyl cellulose and 30 parts of baicalin extract solution. Place the pomegranate peel extract, modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank and stir for 80 minutes at room temperature and 1000 rpm to obtain a mixture.

[0058] S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 8 minutes to perform preliminary degassing.

[0059] S5: Ultrasonic degassing: The mixture after preliminary degassing is taken out of the vacuum drying oven, and the sealed solution is placed in an ultrasonic cleaner for ultrasonic degassing for 9 minutes.

[0060] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 20 hours to degas a second time.

[0061] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 5mm, 75℃ for 10 hours, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0062] The preparation steps for modified chitosan fibers are as follows:

[0063] Chitosan fiber was mixed with deionized water at a mass ratio of 1:80 and stirred at 100℃ and 1000 rpm for 2 hours to dissolve. Then, β-cyclodextrin with a mass ratio of 3 times that of chitosan fiber was added and stirred at 50℃ and 1000 rpm for 30 minutes. Subsequently, acetic acid solution with a mass fraction of 3% and a mass ratio of 0.3 times that of chitosan fiber was added dropwise and stirred at 1000 rpm until the solution became white and viscous. Finally, genipin with a mass fraction of 1% and homemade essential oil with a mass ratio of 0.03 times that of chitosan fiber were added dropwise. After stirring at 1000 rpm for 5 hours, the mixture was placed in a constant temperature water bath at 37℃ and allowed to crosslink for 12 hours until it became gel-like, thus obtaining modified chitosan fiber.

[0064] The preparation process of pomegranate peel extract is as follows:

[0065] The dried pomegranate peel was crushed and passed through an 800-mesh sieve. The resulting pomegranate peel powder was then mixed with an ethanol solution at a mass ratio of 1:30 and soaked for 5 hours. The mixture was then vacuum filtered at 90°C to obtain the supernatant. The supernatant was concentrated by rotary evaporation and then extracted three times with petroleum ether. After concentration and freeze-drying, the pomegranate peel extract was obtained.

[0066] The method for preparing the homemade essential oil is as follows:

[0067] Basil essential oil and an ethanol-water solution of 8% zein (by mass) were placed in a mixing vessel at a volume ratio of 12:1. Then, five times the volume of deionized water was added to the basil essential oil mixture. The mixture was stirred and mixed at 1200 rpm for 30 minutes, then allowed to stand for 30 minutes. The upper suspension was then collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture was then stored at 4°C to obtain the homemade essential oil.

[0068] Example 3

[0069] The specific preparation steps of the hydrocolloid dressing are as follows:

[0070] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:26, and stir for 26 minutes at room temperature and a stirring speed of 500 rpm to obtain a polyvinylpyrrolidone solution.

[0071] S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:20, and stir for 9 minutes at room temperature and a stirring speed of 500 rpm to obtain the baicalin extract solution.

[0072] S3: By weight, take 3 parts of pomegranate peel extract, 15 parts of modified chitosan fiber, 15 parts of hydroxymethyl cellulose and 40 parts of baicalin extract solution. Place the pomegranate peel extract, modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank and stir for 120 minutes at room temperature and a stirring speed of 1300 rpm to obtain a mixture.

[0073] S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 20 minutes to perform preliminary degassing.

[0074] S5: Ultrasonic degassing: After the initial degassing is completed, the mixture is taken out of the vacuum drying oven and the sealed solution is placed in an ultrasonic cleaner for 10 minutes of ultrasonic degassing.

[0075] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 30 hours to degas a second time.

[0076] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 8mm, 75℃, 20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0077] The preparation steps for modified chitosan fibers are as follows:

[0078] Chitosan fiber was mixed with deionized water at a mass ratio of 1:60 and stirred at 90℃ and 900 rpm for 2 hours to dissolve. Then, β-cyclodextrin with a mass ratio of 2 times that of chitosan fiber was added and stirred at 50℃ and 1000 rpm for 20 minutes. Subsequently, acetic acid solution with a mass fraction of 3% and a mass ratio of 0.3 times that of chitosan fiber was added dropwise and stirred at 900 rpm until the solution became white and viscous. Finally, genipin with a mass fraction of 2% and homemade essential oil with a mass ratio of 0.03 times that of chitosan fiber were added dropwise. After stirring at 1000 rpm for 5 hours, the mixture was placed in a 37℃ constant temperature water bath and allowed to crosslink for 12 hours until it became gel-like, thus obtaining modified chitosan fiber.

[0079] The preparation process of pomegranate peel extract is as follows:

[0080] The dried pomegranate peel was crushed and passed through an 800-mesh sieve. The resulting pomegranate peel powder was then mixed with an ethanol solution at a mass ratio of 1:30 and soaked for 3 hours. The mixture was then vacuum filtered at 90°C to obtain the supernatant. The supernatant was concentrated by rotary evaporation and then extracted three times with petroleum ether. After concentration and freeze-drying, the pomegranate peel extract was obtained.

[0081] The method for preparing the homemade essential oil is as follows:

[0082] Basil essential oil and an ethanol-water solution of 8% zein (by mass) were placed in a mixing vessel at a volume ratio of 12:1. Then, five times the volume of deionized water was added to the basil essential oil mixture. The mixture was stirred and mixed at 1200 rpm for 30 minutes, then allowed to stand for 30 minutes. The upper suspension was then collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture was then stored at 4°C to obtain the homemade essential oil.

[0083] Comparative Example 1

[0084] The specific preparation steps of the hydrocolloid dressing are as follows:

[0085] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:26, and stir for 26 minutes at room temperature and a stirring speed of 500 rpm to obtain a polyvinylpyrrolidone solution.

[0086] S2: By weight, take 3 parts of pomegranate peel extract, 15 parts of modified chitosan fiber, 15 parts of hydroxymethyl cellulose and 40 parts of polyvinylpyrrolidone solution. Place the pomegranate peel extract, modified chitosan fiber, hydroxymethyl cellulose and polyvinylpyrrolidone solution in a mixing tank and stir for 120 minutes at room temperature and a stirring speed of 1300 rpm to obtain a mixture.

[0087] S3: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 20 minutes to perform preliminary degassing.

[0088] S4: Ultrasonic degassing: After the initial degassing is completed, the mixture is taken out of the vacuum drying oven and the sealed solution is placed in an ultrasonic cleaner for ultrasonic degassing for 10 minutes.

[0089] S5: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 30 hours to degas a second time.

[0090] S6: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 8mm, 75℃, 20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0091] The preparation steps for modified chitosan fibers are as follows:

[0092] Chitosan fiber was mixed with deionized water at a mass ratio of 1:60 and stirred at 90℃ and 900 rpm for 2 hours to dissolve. Then, β-cyclodextrin with a mass ratio of 2 times that of chitosan fiber was added and stirred at 50℃ and 1000 rpm for 20 minutes. Subsequently, acetic acid solution with a mass fraction of 3% and a mass ratio of 0.3 times that of chitosan fiber was added dropwise and stirred at 900 rpm until the solution became white and viscous. Finally, genipin with a mass fraction of 2% and homemade essential oil with a mass ratio of 0.03 times that of chitosan fiber were added dropwise. After stirring at 1000 rpm for 5 hours, the mixture was placed in a 37℃ constant temperature water bath and allowed to crosslink for 12 hours until it became gel-like, thus obtaining modified chitosan fiber.

[0093] The preparation process of pomegranate peel extract is as follows:

[0094] The dried pomegranate peel was crushed and passed through an 800-mesh sieve. The resulting pomegranate peel powder was then mixed with an ethanol solution at a mass ratio of 1:30 and soaked for 3 hours. The mixture was then vacuum filtered at 90°C to obtain the supernatant. The supernatant was concentrated by rotary evaporation and then extracted three times with petroleum ether. After concentration and freeze-drying, the pomegranate peel extract was obtained.

[0095] The method for preparing the homemade essential oil is as follows:

[0096] Basil essential oil and an ethanol-water solution of 8% zein (by mass) were placed in a mixing vessel at a volume ratio of 12:1. Then, five times the volume of deionized water was added to the basil essential oil mixture. The mixture was stirred and mixed at 1200 rpm for 30 minutes, then allowed to stand for 30 minutes. The upper suspension was then collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture was then stored at 4°C to obtain the homemade essential oil.

[0097] Comparative Example 2

[0098] The specific preparation steps of the hydrocolloid dressing are as follows:

[0099] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:26, and stir for 26 minutes at room temperature and a stirring speed of 500 rpm to obtain a polyvinylpyrrolidone solution.

[0100] S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:20, and stir for 9 minutes at room temperature and a stirring speed of 500 rpm to obtain the baicalin extract solution.

[0101] S3: By weight, take 3 parts of pomegranate peel extract, 15 parts of chitosan fiber, 15 parts of hydroxymethyl cellulose and 40 parts of baicalin extract solution. Place the pomegranate peel extract, modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank and stir for 120 minutes at room temperature and a stirring speed of 1300 rpm to obtain a mixture.

[0102] S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 20 minutes to perform preliminary degassing.

[0103] S5: Ultrasonic degassing: After the initial degassing is completed, the mixture is taken out of the vacuum drying oven and the sealed solution is placed in an ultrasonic cleaner for 10 minutes of ultrasonic degassing.

[0104] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 30 hours to degas a second time.

[0105] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 8mm, 75℃, 20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0106] The preparation process of pomegranate peel extract is as follows:

[0107] The dried pomegranate peel was crushed and passed through an 800-mesh sieve. The resulting pomegranate peel powder was then mixed with an ethanol solution at a mass ratio of 1:30 and soaked for 3 hours. The mixture was then vacuum filtered at 90°C to obtain the supernatant. The supernatant was concentrated by rotary evaporation and then extracted three times with petroleum ether. After concentration and freeze-drying, the pomegranate peel extract was obtained.

[0108] Comparative Example 3

[0109] The specific preparation steps of the hydrocolloid dressing are as follows:

[0110] S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:26, and stir for 26 minutes at room temperature and a stirring speed of 500 rpm to obtain a polyvinylpyrrolidone solution.

[0111] S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:20, and stir for 9 minutes at room temperature and a stirring speed of 500 rpm to obtain the baicalin extract solution.

[0112] S3: By weight, take 15 parts of modified chitosan fiber, 15 parts of hydroxymethyl cellulose and 40 parts of baicalin extract solution. Place pomegranate peel extract, modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank and stir for 120 minutes at room temperature and 1300 rpm to obtain a mixture.

[0113] S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 20 minutes to perform preliminary degassing.

[0114] S5: Ultrasonic degassing: After the initial degassing is completed, the mixture is taken out of the vacuum drying oven and the sealed solution is placed in an ultrasonic cleaner for 10 minutes of ultrasonic degassing.

[0115] S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 30 hours to degas a second time.

[0116] S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 8mm, 75℃, 20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

[0117] The preparation steps for modified chitosan fibers are as follows:

[0118] Chitosan fiber was mixed with deionized water at a mass ratio of 1:60 and stirred at 90℃ and 900 rpm for 2 hours to dissolve. Then, β-cyclodextrin with a mass ratio of 2 times that of chitosan fiber was added and stirred at 50℃ and 1000 rpm for 20 minutes. Subsequently, acetic acid solution with a mass fraction of 3% and a mass ratio of 0.3 times that of chitosan fiber was added dropwise and stirred at 900 rpm until the solution became white and viscous. Finally, genipin with a mass fraction of 2% and homemade essential oil with a mass ratio of 0.03 times that of chitosan fiber were added dropwise. After stirring at 1000 rpm for 5 hours, the mixture was placed in a 37℃ constant temperature water bath and allowed to crosslink for 12 hours until it became gel-like, thus obtaining modified chitosan fiber.

[0119] The method for preparing the homemade essential oil is as follows:

[0120] Basil essential oil and an ethanol-water solution of 8% zein (by mass) were placed in a mixing vessel at a volume ratio of 12:1. Then, five times the volume of deionized water was added to the basil essential oil mixture. The mixture was stirred and mixed at 1200 rpm for 30 minutes, then allowed to stand for 30 minutes. The upper suspension was then collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture was then stored at 4°C to obtain the homemade essential oil.

[0121] Test method: Test product adhesion.

[0122] Table 1

[0123]

[0124]

[0125] By comparing Examples 1-3 and Comparative Examples 1-3 in Table 1, it can be seen that the hydrocolloid dressing prepared by the invention has good adhesion and can act on the wound for a long time, effectively promoting the repair of damaged cells and wounds, thereby promoting the healing of wounds in the oral cavity.

[0126] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

[0127] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

Claims

1. A method for preparing an oral hydrocolloid dressing, characterized in that... The preparation steps of the hydrocolloid dressing are as follows: S1: Polyvinylpyrrolidone and purified water are mixed to obtain a polyvinylpyrrolidone solution; S2: Mix baicalin extract with polyvinylpyrrolidone solution to obtain baicalin extract solution; S3: Chitosan fiber, hydroxymethyl cellulose and baicalin extract solution are mixed to obtain a mixture; S4: Vacuum degassing: The prepared mixture is vacuumed, pressure is maintained, and preliminary degassing is performed; S5: Ultrasonic degassing: The mixture after preliminary degassing is degassed by ultrasound; S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for a second degassing. S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the drying oven, cure it, and cover it with a protective layer to obtain the hydrocolloid dressing. The chitosan fiber mentioned in step S3 is a modified chitosan fiber; The preparation steps of the modified chitosan fiber are as follows: Chitosan fiber and deionized water were mixed at a mass ratio of 1:50-1:80 and stirred at 80-100℃ and 800-1000 rpm for 1-2 hours to dissolve. Then, β-cyclodextrin with a mass ratio of 2-3 times that of chitosan fiber was added and stirred at 30-50℃ and 800-1000 rpm for 20-30 minutes. Subsequently, acetic acid solution with a mass fraction of 2-3% and a mass ratio of 0.2-0.3 times that of chitosan fiber was added dropwise and stirred at 800-1000 rpm until the solution became white and viscous. Finally, genipin with a mass fraction of 1-2% and homemade essential oil with a mass ratio of 0.02-0.03 times that of chitosan fiber were added dropwise. Then, the mixture was stirred at 800-1000 rpm for 3-5 hours and then placed in a 37°C constant temperature water bath for 12 hours to crosslink until it became gel-like, thus obtaining modified chitosan fiber. The oral hydrocolloid dressing also contains pomegranate peel extract; The preparation process of the pomegranate peel extract is as follows: The dried pomegranate peel is crushed and passed through a 600-800 mesh sieve. The obtained pomegranate peel powder is then mixed with an ethanol solution at a mass ratio of 1:20-1:30 and soaked for 3-5 hours. The mixture is then vacuum filtered at a temperature of 80-90℃ to obtain the supernatant. The supernatant is concentrated by rotary evaporation and then extracted with petroleum ether 3-5 times. After concentration and freeze-drying, the pomegranate peel extract is obtained. The method for preparing the homemade essential oil is as follows: Basil essential oil and a 5-8% (w / w) zein ethanol aqueous solution are placed in a mixing vessel at a volume ratio of 8:1-12:

1. Then, 3-5 times the volume of deionized water is added to the basil essential oil mixture. The mixture is stirred and mixed at 1000-1200 rpm for 20-30 minutes, then allowed to stand for 20-30 minutes. The upper suspension is collected and concentrated to one-fifth of its original volume by rotary evaporation. The mixture is then stored at a low temperature of 1-4℃ to obtain the homemade essential oil.

2. The method for preparing an oral hydrocolloid dressing according to claim 1, characterized in that... The specific preparation steps of the hydrocolloid dressing are as follows: S1: Place polyvinylpyrrolidone and purified water in a beaker at a mass ratio of 1:20-1:30, and stir for 20-30 minutes at room temperature and a stirring speed of 400-600 rpm to obtain a polyvinylpyrrolidone solution. S2: Place the baicalin extract and polyvinylpyrrolidone solution in a mixing vessel at a mass ratio of 1:20-1:30, and stir for 9-12 minutes at room temperature and a stirring speed of 300-600 rpm to obtain the baicalin extract solution. S3: By weight, take 10-20 parts of chitosan fiber, 10-20 parts of hydroxymethyl cellulose and 30-50 parts of baicalin extract solution, and place the modified chitosan fiber, hydroxymethyl cellulose and baicalin extract solution in a mixing tank. Stir at room temperature and at a speed of 1000-1300 rpm for 80-120 minutes to obtain a mixture. S4: Vacuum degassing: Place the prepared mixture into a vacuum drying oven, seal it with plastic wrap, and evacuate to -0.095MPa. Hold the pressure for 8-20 minutes to perform preliminary degassing. S5: Ultrasonic degassing: After the initial degassing is completed, the mixture is taken out of the vacuum drying oven and the sealed solution is placed in an ultrasonic cleaner for ultrasonic degassing for 9-15 minutes. S6: Degassing by standing: After the sonication is completed, seal the solution with plastic wrap and let it stand at room temperature for 20-30 hours to degas a second time. S7: Fix the PU film in the film laying frame, pour the degassed mixture into the film laying frame, put it in the forced-air drying oven, keep the liquid level at 5-8mm, 75-90℃, 10-20h, cure, cover with a protective layer, and you will get the hydrocolloid dressing.

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