Washable Pipette Needle Device and Cleaning Method

Abstract

The present invention discloses a washable pipette needle device and a cleaning method. The device includes: a pipette needle module, which includes a pipette needle mounting mechanism and a plurality of pipette needles; an upper cleaning base, which has a plurality of upper inner cavities arranged in an array and an upper cleaning flow channel communicating with all the upper inner cavities; a lower cleaning base, which has a plurality of lower inner cavities arranged in an array and a lower cleaning flow channel communicating with all the lower inner cavities; and a liquid collector for collecting the cleaning liquid waste liquid and compressed air discharged from the upper cleaning base and the lower cleaning base. The washable pipette needle device provided by the present invention, by adopting a washable pipette needle, avoids the problem of a large consumption of pipette tips caused by the need to replace disposable pipette tips between different sample solution pipetting operations in the traditional pipetting method, simplifies the operation, and saves costs; the present invention effectively solves the problems of difficult cleaning of the inner wall of the pipette needle head and liquid hanging on the inner and outer walls, and effectively reduces the probability of the pipette needle carrying pollutants.

Description

Technical Field

[0001] The present invention relates to the technical fields of biology and medical auxiliary equipment, and particularly relates to a washable pipette needle device and a cleaning method therefor. Background Art

[0002] In the field of biological medicine, in order to detect the drug sensitivity of microorganisms such as bacteria, viruses, and fungi to drugs, a culture solution is prepared by mixing the microorganisms such as bacteria, viruses, and fungi with a drug liquid, and then cultivated. Finally, the effect of the drug in the culture solution on the growth of microorganisms such as bacteria, viruses, and fungi is detected.

[0003] Generally, a plurality of drug sensitivity holes are provided on a drug sensitivity plate, and each drug sensitivity hole contains different types and concentrations of drugs. During the cultivation process, a pipette gun is used to sequentially add sample solutions containing microorganisms such as bacteria, viruses, and fungi to the drug sensitivity holes of the drug sensitivity plate, which is slow and requires a large workload for personnel. At the same time, if disposable pipette tips are used, the disposable tips need to be replaced between the addition of different sample solutions, resulting in a large consumption of tips.

[0004] In addition, if the traditional method is used to clean the pipette tip, it is difficult to clean the inner wall of the needle tip, and there will be liquid hanging on the inner and outer walls. This will not only affect the accuracy of liquid addition, but also increase the probability of the pipette needle carrying contaminants. At the same time, the drug sensitivity detection of microorganisms such as bacteria, viruses, and fungi requires high sensitivity, so high requirements are imposed on both the needle cleaning efficiency and the needle cleaning effect.

[0005] Therefore, it is necessary to improve the existing technology now to provide a more reliable solution. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to provide a washable pipette needle device and a cleaning method therefor in view of the deficiencies in the above-mentioned prior art.

[0007] To solve the above technical problem, the technical solution adopted by the present invention is: a washable pipette needle device, comprising:

[0008] A pipette needle module, which includes a pipette needle mounting mechanism and a plurality of pipette needles arranged in an array and connected to the pipette needle mounting mechanism. At least one air inlet and at least one liquid inlet are provided on the side wall of the pipette needle, and the air inlet is above the liquid inlet;

[0009] An upper cleaning base, which has a plurality of upper inner cavities arranged in an array for the pipette needles to be inserted, and an upper cleaning flow channel communicating with all the upper inner cavities. After the pipette needles are inserted into the upper inner cavities, the upper cleaning flow channel communicates with the air inlet and the liquid inlet of the pipette needles respectively to inject compressed air and cleaning liquid into the pipette needles, so as to clean the inner wall of the pipette needles;

[0010] A lower cleaning base is disposed below the upper cleaning base. The lower cleaning base has a plurality of lower inner cavities arranged in an array for the pipetting needle to be inserted, and a lower cleaning channel communicating with all the lower inner cavities. After the lower part of the pipetting needle passes through the upper inner cavity and is inserted into the lower inner cavity, a lower cleaning cavity is formed between the pipetting needle and the lower inner cavity, so as to inject cleaning liquid and compressed air into the lower cleaning cavity through the cleaning channel, thereby cleaning the outer wall of the pipetting needle.

[0011] And a liquid collector is disposed below the lower cleaning base for collecting the waste cleaning liquid and compressed air discharged from the upper cleaning base and the lower cleaning base.

[0012] Preferably, the pipetting needle mounting mechanism includes an end cap, a sliding cavity formed in the middle of the bottom end of the end cap, a slider disposed in the sliding cavity, and an annular baffle connected to the bottom end of the end cap.

[0013] The upper edge of the upper end of the slider protrudes outward to form a sliding portion. The sliding portion is slidably disposed in the sliding cavity. The lower end of the slider extends downward from the middle of the annular baffle. The annular baffle is used to abut against the bottom surface of the sliding portion so that the sliding portion cannot be disengaged from the sliding cavity downward.

[0014] Preferably, a spring is sleeved on the pipetting needle. The upper end of the spring abuts against the upper inner wall of the sliding cavity, and the lower end abuts against the upper surface of the slider.

[0015] A plurality of mounting holes for the pipetting needle to be inserted are arranged in an array on the slider. A first circular seal ring and a second circular seal ring are vertically spaced along the inner edge of each mounting hole. When the slider is not affected by an external force, the air inlet and the liquid inlet on the pipetting needle are both located between the first circular seal ring and the second circular seal ring, so that the air inlet and the liquid inlet are both sealed by the cooperation of the first circular seal ring, the second circular seal ring and the inner wall of the needle hole.

[0016] Preferably, the upper cleaning channel includes an upper air channel and an upper liquid channel located below the upper air channel. The upper air channel includes a plurality of upper air sub-channels arranged vertically and horizontally, so that all the upper inner cavities in the upper cleaning base are communicated with the upper air sub-channels; the upper liquid channel includes a plurality of upper liquid sub-channels arranged vertically and horizontally, so that all the upper inner cavities in the upper cleaning base are also communicated with the upper liquid sub-channels.

[0017] An upper distributor is provided on the side of the upper cleaning base for respectively providing compressed air and cleaning liquid for the upper air channel and the upper liquid channel in the upper cleaning channel.

[0018] Preferably, an upper air distribution structure communicating with the upper air flow channel and an upper cleaning liquid distribution structure communicating with the upper liquid flow channel are arranged in the upper distributor;

[0019] The upper air distribution structure includes an upper air inlet joint arranged on the upper distributor, an upper air cavity opened in the upper distributor and communicating with the upper air inlet joint, a plurality of upper air distribution channels communicating with the upper air cavity, and an upper air adapter joint communicating the upper air distribution channels and the upper air sub-channels;

[0020] The upper cleaning liquid distribution structure includes an upper cleaning liquid inlet joint arranged on the upper distributor, an upper cleaning liquid cavity opened in the upper distributor and communicating with the upper cleaning liquid inlet joint, a plurality of upper cleaning liquid distribution channels communicating with the upper cleaning liquid cavity, and an upper cleaning liquid adapter joint communicating the upper cleaning liquid distribution channels and the upper liquid sub-channels.

[0021] Preferably, the lower cleaning flow channel includes a lower air flow channel and a lower liquid flow channel located below the lower air flow channel. The lower air flow channel includes a plurality of lower air sub-channels arranged vertically and horizontally, so that all the lower inner cavities in the lower cleaning base are communicated with the lower air sub-channels; the lower liquid flow channel includes a plurality of lower liquid sub-channels arranged vertically and horizontally, so that all the lower inner cavities in the lower cleaning base are also communicated with the lower liquid sub-channels;

[0022] A lower distributor for providing compressed air and cleaning liquid for the lower air flow channel and the lower liquid flow channel in the lower cleaning flow channel respectively is arranged on the side of the lower cleaning base.

[0023] Preferably, a lower air distribution structure communicating with the lower air flow channel and a lower cleaning liquid distribution structure communicating with the lower liquid flow channel are arranged in the lower distributor;

[0024] The lower air distribution structure includes a lower air inlet joint arranged on the lower distributor, a lower air cavity opened in the lower distributor and communicating with the lower air inlet joint, a plurality of lower air distribution channels communicating with the lower air cavity, and a lower air adapter joint communicating the lower air distribution channels and the lower air sub-channels;

[0025] The lower cleaning liquid distribution structure includes a lower cleaning liquid inlet joint arranged on the lower distributor, a lower cleaning liquid cavity opened in the lower distributor and communicating with the lower cleaning liquid inlet joint, a plurality of lower cleaning liquid distribution channels communicating with the lower cleaning liquid cavity, and a lower cleaning liquid adapter joint communicating the lower cleaning liquid distribution channels and the lower liquid sub-channels.

[0026] Preferably, the upper inner cavity and the lower inner cavity at the same vertical position communicate with each other up and down.

[0027] A liquid collecting cavity communicating with the bottoms of all the lower inner cavities on the lower cleaning base is formed on the liquid collector, so as to collect the cleaning liquid waste liquid and compressed air discharged from the inside of the pipette needle and the lower inner cavity through the liquid collecting cavity.

[0028] A mixed discharge joint communicating with the liquid collecting cavity is arranged on the side of the liquid collector.

[0029] Preferably, the upper cleaning base and the lower cleaning base are sealed by a first rectangular sealing ring, and the lower cleaning base and the liquid collector are sealed by a second rectangular sealing ring.

[0030] Preferably, the method for cleaning the pipette needle by the cleanable pipette needle device includes the following steps:

[0031] S1. Place the pipette needle module on the upper cleaning base, and insert the lower part of the pipette needle into the upper inner cavity and the lower inner cavity in sequence. Apply a downward pressure to the pipette needle module, so that the slider is squeezed by the upper cleaning base and retracts into the sliding cavity, thereby making the slider move upward relative to the pipette needle until the annular baffle at the bottom of the pipette needle installation mechanism abuts against the upper surface of the upper cleaning base. At this time, both the first circular sealing ring and the second circular sealing ring move above the air inlet of the pipette needle, and the air inlet and the liquid inlet are respectively communicated with the upper air sub-channel and the upper liquid sub-channel.

[0032] S2. Inject cleaning liquid into the upper liquid sub-channel through the upper distributor, and enter the inside of the pipette needle through the liquid inlet to clean the inner wall of the pipette needle.

[0033] Inject cleaning liquid into the lower liquid sub-channel through the lower distributor, and enter the lower cleaning cavity formed by the gap between the pipette needle and the lower inner cavity to clean the outer wall of the pipette needle.

[0034] S3. After the cleaning liquid cleaning is completed, input clean compressed air into the upper air sub-channel through the upper distributor, and enter the inside of the pipette needle through the air inlet to blow and wash the inner wall of the pipette needle to remove the residual cleaning liquid on the inner wall.

[0035] Input clean compressed air into the lower air sub-channel through the lower distributor, and enter the lower cleaning cavity formed by the gap between the pipette needle and the lower inner cavity to blow and wash the outer wall of the pipette needle to remove the residual cleaning liquid on the outer wall.

[0036] S4. After the compressed air purge is completed, remove the pressure applied to the pipette needle module. Under the elastic force of the spring, the slider moves downward relative to the sliding cavity, causing the slider to move downward relative to the pipette needle until the sliding part of the slider abuts against the annular baffle. At this time, both the first circular seal ring and the second circular seal ring move to their initial positions: the air inlet and the liquid inlet on the pipette needle are both between the first circular seal ring and the second circular seal ring, and finally the air inlet and the liquid inlet are both closed under the cooperation of the first circular seal ring, the second circular seal ring and the inner wall of the needle hole.

[0037] The beneficial effects of the present invention are as follows:

[0038] The cleanable pipette needle device provided by the present invention uses a cleanable pipette needle, avoiding the problem of a large consumption of pipette tips caused by the need to replace disposable pipette tips between different sample solutions in traditional pipetting methods, simplifying the operation and saving costs.

[0039] The pipette needle of the present invention is provided with independent air inlets and liquid inlets, and in cooperation with the overall device, cleaning liquid can be introduced through the liquid inlet to clean the inner wall of the pipette needle to remove residual impurities, and compressed air can be introduced through the air inlet to blow and remove the cleaning liquid remaining on the inner wall of the pipette needle; and the air inlet is arranged above the liquid inlet to effectively blow and clean the cleaning liquid remaining on the inner and outer walls of the pipette needle, avoiding the influence of the remaining liquid on the pipette needle wall on the liquid suction accuracy.

[0040] The present invention effectively solves the problems of difficult cleaning of the inner wall of the pipette needle head and liquid hanging on the inner and outer walls, and effectively reduces the probability of the pipette needle carrying pollutants. Description of the Drawings

[0041] Figure 1 It is a schematic structural diagram of the cleanable pipette needle device of the present invention;

[0042] Figure 2 It is a schematic structural diagram of the pipette needle module of the present invention;

[0043] Figure 3 It is a schematic cross-sectional structural diagram of the pipette needle module of the present invention on the A side;

[0044] Figure 4 It is a schematic structural diagram of the end cap of the present invention;

[0045] Figure 5 It is a schematic structural diagram of the annular baffle of the present invention;

[0046] Figure 6 It is a schematic structural diagram of the slider of the present invention;

[0047] Figure 7 It is a schematic cross-sectional structural diagram of the pipette needle of the present invention;

[0048] Figure 8 Schematic structural diagram of the combined installation of the upper cleaning base, lower cleaning base and liquid collector of the present invention;

[0049] Figure 9 Schematic cross-sectional structural diagram after the combined installation of the upper cleaning base, lower cleaning base and liquid collector of the present invention;

[0050] Figure 10 Schematic structural diagram of the upper cleaning base of the present invention;

[0051] Figure 11 Schematic cross-sectional structural diagram of the upper cleaning base of the present invention on surface B;

[0052] Figure 12 Schematic cross-sectional structural diagram of the upper cleaning base of the present invention on surface C;

[0053] Figure 13 Schematic structural diagram of the lower cleaning base of the present invention;

[0054] Figure 14 Schematic cross-sectional structural diagram of the lower cleaning base of the present invention on surface D;

[0055] Figure 15 Schematic cross-sectional structural diagram of the lower cleaning base of the present invention on surface E;

[0056] Figure 16 Schematic structural diagram of the liquid collector of the present invention;

[0057] Figure 17 Schematic cross-sectional structural diagram of the overall cleanable pipetting needle device of the present invention;

[0058] Figure 18 Schematic cross-sectional structural diagram of the cooperation between the upper air distribution structure and the upper air flow channel of the present invention;

[0059] Figure 19 Schematic cross-sectional structural diagram of the cooperation between the upper cleaning liquid distribution structure and the upper cleaning liquid flow channel of the present invention;

[0060] Figure 20 Schematic cross-sectional structural diagram of the cooperation between the lower air distribution structure and the lower air flow channel of the present invention;

[0061] Figure 21 Schematic cross-sectional structural diagram of the cooperation between the lower cleaning liquid distribution structure and the lower cleaning liquid flow channel of the present invention.

[0062] Explanation of reference numerals:

[0063] 1 - Pipetting needle module; 10 - Pipetting needle mounting mechanism; 11 - Pipetting needle; 110 - Air inlet; 111 - Liquid inlet; 100 - End cap; 101 - Sliding cavity; 102 - Slide block; 103 - Annular baffle; 104 - Sliding part; 105 - Spring; 106 - Mounting hole; 107 - First circular sealing ring; 108 - Second circular sealing ring; 109 - Threaded hole;

[0064] 2 - Upper cleaning base; 20 - Upper inner cavity; 21 - Upper cleaning flow channel; 22 - Upper air flow channel; 23 - Upper liquid flow channel; 24 - Upper distributor; 25 - Upper air distribution structure; 26 - Upper cleaning liquid distribution structure; 220 - Upper air sub-channel; 230 - Upper liquid sub-channel;

[0065] 250 - Upper air inlet joint; 251 - Upper air cavity; 252 - Upper air distribution flow channel; 253 - Upper air adapter;

[0066] 260 - Upper cleaning liquid inlet joint; 261 - Upper cleaning liquid cavity; 262 - Upper cleaning liquid distribution flow channel; 263 - Upper cleaning liquid adapter;

[0067] 3 - Lower cleaning base; 30 - Lower inner cavity; 31 - Lower cleaning flow channel; 32 - Lower air flow channel;

[0068] 33 - Lower liquid flow channel; 34 - Lower distributor; 35 - Lower air distribution structure; 36 - Lower cleaning liquid distribution structure; 37 - Lower cleaning cavity; 38 - First rectangular sealing ring; 320 - Lower air sub-channel; 330 - Lower liquid sub-channel;

[0069] 350 - Lower air inlet joint; 351 - Lower air cavity; 352 - Lower air distribution flow channel; 353 - Lower air adapter;

[0070] 360 - Lower cleaning liquid inlet joint; 361 - Lower cleaning liquid cavity; 362 - Lower cleaning liquid distribution flow channel; 363 - Lower cleaning liquid adapter;

[0071] 4 - Liquid collector; 40 - Liquid collection cavity; 41 - Mixed discharge joint; 42 - Second rectangular sealing ring. Detailed implementation mode

[0072] The following further describes the present invention in detail with reference to embodiments, so that those skilled in the art can implement it according to the text of the specification.

[0073] It should be understood that terms such as "having", "comprising" and "including" as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0074] Embodiment 1

[0075] AsFigure 1-21 As shown in Figure 1-21 , a washable pipette needle 11 device according to this embodiment includes:

[0076] A pipette needle module 1, which includes a pipette needle mounting mechanism 10 and a plurality of pipette needles 11 arranged in an array and connected to the pipette needle mounting mechanism 10. At least one air inlet 110 and at least one liquid inlet 111 are provided on the side wall of the pipette needle 11, and the air inlet 110 is above the liquid inlet 111;

[0077] An upper cleaning base 2, which has a plurality of upper inner cavities 20 arranged in an array for the pipette needles 11 to be inserted, and an upper cleaning flow channel 21 communicating with all the upper inner cavities 20. After the pipette needle 11 is inserted into the upper inner cavity 20, the upper cleaning flow channel 21 communicates with the air inlet 110 and the liquid inlet 111 of the pipette needle 11 respectively to inject compressed air and cleaning liquid into the pipette needle 11, so as to clean the inner wall of the pipette needle 11;

[0078] A lower cleaning base 3, which is arranged below the upper cleaning base 2. The lower cleaning base 3 has a plurality of lower inner cavities 30 arranged in an array for the pipette needles 11 to be inserted, and a lower cleaning flow channel 31 communicating with all the lower inner cavities 30. After the lower part of the pipette needle 11 passes through the upper inner cavity 20 and is inserted into the lower inner cavity 30, the gap between the pipette needle 11 and the lower inner cavity 30 forms a lower cleaning cavity 37, so as to inject cleaning liquid and compressed air into the lower cleaning cavity 37 through the cleaning flow channel, so as to clean the outer wall of the pipette needle 11;

[0079] And a liquid collector 4, which is arranged below the lower cleaning base 3 and is used to collect the cleaning liquid waste liquid and compressed air discharged from the upper cleaning base 2 and the lower cleaning base 3. The following describes each mechanism of the present invention in detail.

[0080] Pipetting needle module 1

[0081] Referring to Figure 1-7 , in this embodiment, a plurality of pipette needles 11 are arranged in an array on the pipette needle mounting mechanism 10, which can meet the requirement of pipetting multiple holes of a drug sensitivity plate simultaneously, saving the cumbersome process of frequent pipetting with a single pipette needle 11. At the same time, these pipette needles 11 can be cleaned, avoiding the waste caused by replacing disposable pipette tips.

[0082] In this embodiment, two air inlets 110 at the same horizontal position and two liquid inlets 111 at the same horizontal position are provided on the pipetting needle 11. Through the settings of the air inlets 110 and the liquid inlets 111, cleaning liquid and clean compressed air can be injected into the interior of the pipetting needle 11, enabling efficient cleaning of the inner wall of the pipetting needle 11 and blowing the residual cleaning liquid on the inner wall clean, avoiding the situation of liquid hanging on the inner wall of the pipetting needle 11, and effectively solving the problem of difficult cleaning of the inner wall of the pipetting needle 11. Further, the two air inlets 110 are located above the two liquid inlets 111, which can effectively blow the cleaning liquid remaining on the inner and outer walls of the pipetting needle 11 clean, avoiding the influence of the residual liquid on the pipetting needle 11 wall on the pipetting accuracy.

[0083] Among them, the pipetting needle mounting mechanism 10 includes an end cap 100, a sliding cavity 101 formed in the middle of the bottom end of the end cap 100, a slider 102 disposed in the sliding cavity 101, and an annular baffle 103 connected to the bottom end of the end cap 100; a plurality of threaded holes 109 for threadedly connecting the pipetting needle 11 are formed on the end cap 100.

[0084] The upper edge of the upper end of the slider 102 protrudes outward to form a sliding portion 104. The sliding portion 104 is slidably disposed in the sliding cavity 101. The lower end of the slider 102 extends downward from the middle of the annular baffle 103. The annular baffle 103 is used to abut against the bottom surface of the sliding portion 104 so that the sliding portion 104 cannot be disengaged from the sliding cavity 101 downward.

[0085] Among them, a spring 105 is sleeved on the pipetting needle 11. The upper end of the spring 105 abuts against the upper inner wall of the sliding cavity 101, and the lower end abuts against the upper surface of the slider 102; in a preferred embodiment, grooves for fitting and accommodating the spring 105 are formed on both the upper inner wall of the sliding cavity 101 and the upper surface of the block.

[0086] A plurality of mounting holes 106 for inserting the pipetting needle 11 are arranged in an array on the slider 102. A first circular sealing ring 107 and a second circular sealing ring 108 are vertically spaced along the inner edge of each mounting hole 106. When the slider 102 is not subjected to an external force, both the air inlet 110 and the liquid inlet 111 on the pipetting needle 11 are located between the first circular sealing ring 107 and the second circular sealing ring 108. Thus, through the cooperation of the first circular sealing ring 107, the second circular sealing ring 108 and the inner wall of the needle hole, both the air inlet 110 and the liquid inlet 111 are sealed, so that the pipetting needle always remains airtight during the pipetting operation.

[0087] Upper cleaning base 2

[0088] Refer to Figure 8-12In this embodiment, the upper cleaning flow channel 21 includes an upper air flow channel 22 and an upper liquid flow channel 23 located below the upper air flow channel 22. The upper air flow channel 22 includes a plurality of upper air sub-flow channels 220 arranged in a criss-cross pattern, so that all upper inner cavities 20 in the upper cleaning base 2 are connected to the upper air sub-flow channels 220; the upper liquid flow channel 23 includes a plurality of upper liquid sub-flow channels 230 arranged in a criss-cross pattern, so that all upper inner cavities 20 in the upper cleaning base 2 are also connected to the upper liquid sub-flow channels 230;

[0089] Refer to Figure 17-19 An upper distributor 24 is provided on the side of the upper cleaning base 2 for providing compressed air and cleaning liquid to the upper air flow channel 22 and the upper liquid flow channel 23 in the upper cleaning flow channel 21 , respectively.

[0090] The upper distributor 24 is provided with an upper air distribution structure 25 communicating with the upper air flow channel 22 and an upper cleaning liquid distribution structure 26 communicating with the upper liquid flow channel 23;

[0091] The upper air distribution structure 25 includes an upper air inlet joint 250 disposed on the upper distributor 24, an upper air receiving chamber 251 opened in the upper distributor 24 and communicating with the upper air inlet joint 250, a plurality of upper air distribution channels 252 communicating with the upper air receiving chamber 251, and an upper air transfer joint 253 communicating with the upper air distribution channels 252 and the upper air sub-channels 220;

[0092] The upper cleaning liquid distribution structure 26 includes an upper cleaning liquid inlet joint 260 arranged on the upper distributor 24, an upper cleaning liquid holding chamber 261 opened in the upper distributor 24 and connected to the upper cleaning liquid inlet joint 260, a plurality of upper cleaning liquid distribution channels 262 connected to the upper cleaning liquid holding chamber 261, and an upper cleaning liquid transfer joint 263 connecting the upper cleaning liquid distribution channels 262 and the upper liquid sub-channels 230.

[0093] The upper air chamber 251 and the upper cleaning liquid chamber 261 are used for temporarily storing and distributing cleaning liquid and compressed air. The upper air inlet connector 250 is connected to an external compressed air source, and the upper cleaning liquid inlet connector 260 is connected to an external cleaning liquid source with a certain flow rate.

[0094] Multiple upper air distribution channels 252 and upper cleaning liquid distribution channels 262 are used to evenly and quickly distribute compressed air and cleaning liquid to multiple upper air sub-channels 220 and upper liquid sub-channels 230. Several upper air sub-channels 220 and upper liquid sub-channels 230 in a criss-cross structure (or a well-shaped structure) are used to connect multiple upper inner cavities 20, thereby providing compressed air and cleaning liquid to all upper inner cavities 20, and the provision of compressed air and cleaning liquid is independent of each other.

[0095] Lower cleaning base 3

[0096] Referring to Figure 13-15 Figure 13-15 , in this embodiment, the lower cleaning channel 31 includes a lower air channel 32 and a lower liquid channel 33 located below the lower air channel 32. The lower air channel 32 includes a plurality of lower air sub-channels 320 arranged vertically and horizontally, so that all the lower inner cavities 30 in the lower cleaning base 3 are connected to the lower air sub-channels 320; the lower liquid channel 33 includes a plurality of lower liquid sub-channels 330 arranged vertically and horizontally, so that all the lower inner cavities 30 in the lower cleaning base 3 are also connected to the lower liquid sub-channels 330;

[0097] Referring again to Figure 20-21 Figure 20-21 , a lower distributor 34 is provided on the side of the lower cleaning base 3 for supplying compressed air and cleaning liquid to the lower air channel 32 and the lower liquid channel 33 in the lower cleaning channel 31 respectively.

[0098] Among them, a lower air distribution structure 35 communicated with the lower air channel 32 and a lower cleaning liquid distribution structure 36 communicated with the lower liquid channel 33 are provided in the lower distributor 34;

[0099] The lower air distribution structure 35 includes a lower air inlet joint 350 provided on the lower distributor 34, a lower air cavity 351 opened in the lower distributor 34 and communicated with the lower air inlet joint 350, a plurality of lower air distribution channels 352 communicated with the lower air cavity 351, and a lower air adapter 353 communicating the lower air distribution channels 352 and the lower air sub-channels 320;

[0100] The lower cleaning liquid distribution structure 36 includes a lower cleaning liquid inlet joint 360 provided on the lower distributor 34, a lower cleaning liquid cavity 361 opened in the lower distributor 34 and communicated with the lower cleaning liquid inlet joint 360, a plurality of lower cleaning liquid distribution channels 362 communicated with the lower cleaning liquid cavity 361, and a lower cleaning liquid adapter 363 communicating the lower cleaning liquid distribution channels 362 and the lower liquid sub-channels 330.

[0101] The main structures such as the lower distributor 34 and the lower cleaning liquid distribution structure 36 in the lower cleaning base 3 are the same as those in the upper cleaning base 2, and will not be described in detail here. The main difference is that the lower cleaning base 3 is used to clean the outer wall of the pipetting needle 11. The lower part of the pipetting needle 11 is inserted into the lower inner cavity 30 of the lower cleaning base 3, and there is a gap between the outer wall of the pipetting needle 11 and the lower inner cavity 30. The lower cleaning cavity 37 formed by this gap, so that by injecting compressed air and cleaning liquid into the lower cleaning cavity 37, the cleaning of the outer wall of the pipetting needle 11 can be realized.

[0102] Liquid collector 4

[0103] Referring to Figure 16, in this embodiment, a liquid collecting cavity 40 communicating with the bottoms of all the lower inner cavities 30 on the lower cleaning base 3 is formed on the liquid collector 4, so as to collect the cleaning liquid waste liquid and compressed air discharged inside the pipetting needle 11 and in the lower inner cavity 30 through the liquid collecting cavity 40; since the upper inner cavity 20 and the lower inner cavity 30 at the same vertical position communicate with each other up and down, the cleaning liquid waste liquid and compressed air discharged inside the pipetting needle 11 and in the lower inner cavity 30 can flow downward into the liquid collecting cavity 40.

[0104] Wherein, a mixing discharge joint 41 communicating with the liquid collecting cavity 40 is arranged on the side of the liquid collector 4, for discharging the cleaning liquid waste liquid and compressed air inside to the outside.

[0105] In a preferred embodiment, the upper cleaning base 2 and the lower cleaning base 3 are kept sealed by a first rectangular sealing ring 38, and the lower cleaning base 3 and the liquid collector 4 are kept sealed by a second rectangular sealing ring 42.

[0106] Embodiment 2

[0107] This embodiment provides a method for cleaning the pipetting needle 11 by using the cleanable pipetting needle 11 device of Embodiment 1, and the method includes the following steps:

[0108] S1. Place the pipetting needle module 1 on the upper cleaning base 2, and insert the lower part of the pipetting needle 11 into the upper inner cavity 20 and the lower inner cavity 30 in sequence, apply a downward pressure to the pipetting needle module 1, so that the slider 102 is squeezed by the upper cleaning base 2 and retracts into the sliding cavity 101, thereby making the slider 102 move upward relative to the pipetting needle 11 until the annular baffle 103 at the bottom of the pipetting needle mounting mechanism 10 abuts against the upper surface of the upper cleaning base 2. At this time, both the first circular sealing ring 107 and the second circular sealing ring 108 move above the air inlet 110 of the pipetting needle 11, and the air inlet 110 and the liquid inlet 111 communicate with the upper air sub-channel 220 and the upper liquid sub-channel 230 respectively;

[0109] S2. Inject the cleaning liquid into the upper liquid sub-channel 230 through the upper distributor 24, and enter the pipetting needle 11 through the liquid inlet 111 to clean the inner wall of the pipetting needle 11;

[0110] Inject the cleaning liquid into the lower liquid sub-channel 330 through the lower distributor 34, and enter the lower cleaning cavity 37 formed by the gap between the pipetting needle 11 and the lower inner cavity 30 to clean the outer wall of the pipetting needle 11;

[0111] S3. After the cleaning with the cleaning liquid is completed, input clean compressed air into the upper air sub-channel 220 through the upper distributor 24, and enter the pipetting needle 11 through the air inlet 110 to blow and wash the inner wall of the pipetting needle 11 to remove the residual cleaning liquid on the inner wall;

[0112] Clean compressed air is input into the lower air sub-channel 320 through the lower distributor 34 and enters the lower cleaning cavity 37 formed by the gap between the pipetting needle 11 and the lower inner cavity 30 to blow-wash the outer wall of the pipetting needle 11 and remove the cleaning liquid remaining on the outer wall.

[0113] S4. After the compressed air blow-washing is completed, the pressure applied to the pipetting needle module 1 is removed. Under the elastic force of the spring 105, the slider 102 moves downward relative to the sliding cavity 101, so that the slider 102 moves downward relative to the pipetting needle 11 until the sliding portion 104 of the slider 102 abuts against the annular baffle 103. At this time, both the first circular sealing ring 107 and the second circular sealing ring 108 move to the initial positions: the air inlet 110 and the liquid inlet 111 on the pipetting needle 11 are both between the first circular sealing ring 107 and the second circular sealing ring 108, and finally the air inlet 110 and the liquid inlet 111 are both sealed under the cooperation of the first circular sealing ring 107, the second circular sealing ring 108 and the inner wall of the needle hole, thus ensuring the tightness of the pipetting needle 11 during the pipetting process.

[0114] Although the embodiments of the present invention have been disclosed as above, they are not limited to only the applications listed in the specification and embodiments. It can be fully applied to various fields suitable for the present invention. For those familiar with the field, additional modifications can be easily made. Therefore, without departing from the general concept defined by the claims and the equivalent scope, the present invention is not limited to specific details.

Claims

1. A washable pipette needle device, characterized in that, Comprising: A pipetting needle module, which includes a pipetting needle mounting mechanism and a plurality of pipetting needles arranged in an array and connected to the pipetting needle mounting mechanism. At least one air inlet and at least one liquid inlet are provided on the side wall of the pipetting needle, and the air inlet is above the liquid inlet. An upper cleaning base, which has a plurality of upper inner cavities arranged in an array for the pipetting needles to be inserted therein and an upper cleaning flow channel communicating with all the upper inner cavities. After the pipetting needle is inserted into the upper inner cavity, the upper cleaning flow channel communicates with the air inlet and the liquid inlet of the pipetting needle respectively to inject compressed air and cleaning liquid into the pipetting needle, so as to clean the inner wall of the pipetting needle. A lower cleaning base, which is arranged below the upper cleaning base. The lower cleaning base has a plurality of lower inner cavities arranged in an array for the pipetting needles to be inserted therein and a lower cleaning flow channel communicating with all the lower inner cavities. After the lower part of the pipetting needle passes through the upper inner cavity and is inserted into the lower inner cavity, the gap between the pipetting needle and the lower inner cavity forms a lower cleaning cavity, so as to inject cleaning liquid and compressed air into the lower cleaning cavity through the cleaning flow channel, thereby cleaning the outer wall of the pipetting needle. And a liquid collector, which is arranged below the lower cleaning base and is used to collect the cleaning liquid waste liquid and compressed air discharged from the upper cleaning base and the lower cleaning base. The pipetting needle mounting mechanism includes an end cover, a sliding cavity formed in the middle of the bottom end of the end cover, a slider arranged in the sliding cavity, and an annular baffle connected to the bottom end of the end cover. The upper edge of the upper end of the slider protrudes outward to form a sliding part, the sliding part is slidably arranged in the sliding cavity, the lower end of the slider extends downward from the middle of the annular baffle, and the annular baffle is used to abut against the bottom surface of the sliding part so that the sliding part cannot be separated from the sliding cavity downward. A spring is sleeved on the pipetting needle, the upper end of the spring abuts against the upper inner wall of the sliding cavity, and the lower end abuts against the upper surface of the slider. A plurality of mounting holes for the pipetting needles to be inserted are arranged in an array on the slider. A first circular seal ring and a second circular seal ring are vertically spaced along each mounting hole. When the slider is not affected by an external force, the air inlet and the liquid inlet on the pipetting needle are both between the first circular seal ring and the second circular seal ring, so that the air inlet and the liquid inlet are both closed by the cooperation of the first circular seal ring, the second circular seal ring and the inner wall of the needle hole.

2. The washable pipette needle device according to claim 1, characterized in that, The upper cleaning flow channel includes an upper air flow channel and an upper liquid flow channel located below the upper air flow channel. The upper air flow channel includes a plurality of upper air sub-flow channels arranged vertically and horizontally, so that all the upper inner cavities in the upper cleaning base are communicated with the upper air sub-flow channels; the upper liquid flow channel includes a plurality of upper liquid sub-flow channels arranged vertically and horizontally, so that all the upper inner cavities in the upper cleaning base are also communicated with the upper liquid sub-flow channels. An upper distributor is arranged on the side of the upper cleaning base and is used to provide compressed air and cleaning liquid for the upper air flow channel and the upper liquid flow channel in the upper cleaning flow channel respectively.

3. The washable pipette needle device according to claim 2, characterized in that, An upper air distribution structure communicating with the upper air flow channel and an upper cleaning liquid distribution structure communicating with the upper liquid flow channel are arranged in the upper distributor; The upper air distribution structure includes an upper air inlet joint arranged on the upper distributor, an upper air cavity opened in the upper distributor and communicating with the upper air inlet joint, a plurality of upper air distribution channels communicating with the upper air cavity, and an upper air adapter joint communicating the upper air distribution channels and the upper air sub-channels; The upper cleaning liquid distribution structure includes an upper cleaning liquid inlet joint arranged on the upper distributor, an upper cleaning liquid cavity opened in the upper distributor and communicating with the upper cleaning liquid inlet joint, a plurality of upper cleaning liquid distribution channels communicating with the upper cleaning liquid cavity, and an upper cleaning liquid adapter joint communicating the upper cleaning liquid distribution channels and the upper liquid sub-channels.

4. The washable pipette needle device according to claim 3, characterized in that, The lower cleaning channel includes a lower air flow channel and a lower liquid flow channel located below the lower air flow channel. The lower air flow channel includes a plurality of lower air sub-channels arranged vertically and horizontally, so that all the lower inner cavities in the lower cleaning base are communicated with the lower air sub-channels; the lower liquid flow channel includes a plurality of lower liquid sub-channels arranged vertically and horizontally, so that all the lower inner cavities in the lower cleaning base are also communicated with the lower liquid sub-channels; A lower distributor for providing compressed air and cleaning liquid for the lower air flow channel and the lower liquid flow channel in the lower cleaning channel respectively is arranged on the side of the lower cleaning base.

5. The washable pipette needle device according to claim 4, wherein, A lower air distribution structure communicating with the lower air flow channel and a lower cleaning liquid distribution structure communicating with the lower liquid flow channel are arranged in the lower distributor; The lower air distribution structure includes a lower air inlet joint arranged on the lower distributor, a lower air cavity opened in the lower distributor and communicating with the lower air inlet joint, a plurality of lower air distribution channels communicating with the lower air cavity, and a lower air adapter joint communicating the lower air distribution channels and the lower air sub-channels; The lower cleaning liquid distribution structure includes a lower cleaning liquid inlet joint arranged on the lower distributor, a lower cleaning liquid cavity opened in the lower distributor and communicating with the lower cleaning liquid inlet joint, a plurality of lower cleaning liquid distribution channels communicating with the lower cleaning liquid cavity, and a lower cleaning liquid adapter joint communicating the lower cleaning liquid distribution channels and the lower liquid sub-channels.

6. The washable pipette needle device according to claim 5, characterized in that, The upper inner cavity and the lower inner cavity at the same vertical position communicate with each other vertically; A liquid collection cavity communicating with the bottoms of all the lower inner cavities on the lower cleaning base is opened on the liquid collector to collect the cleaning liquid waste liquid and compressed air discharged from inside the pipette tip and the lower inner cavities through the liquid collection cavity; A mixed discharge joint communicating with the liquid collection cavity is arranged on the side of the liquid collector.

7. The washable pipette needle device according to claim 6, wherein Sealing is maintained between the upper cleaning base and the lower cleaning base through a first rectangular sealing ring, and sealing is maintained between the lower cleaning base and the liquid collector through a second rectangular sealing ring.

8. The washable pipette needle device according to claim 7, wherein, The method for cleaning the pipette tip by this device includes the following steps: S1. Place the pipetting needle module on the upper cleaning base, and insert the lower part of the pipetting needle into the upper inner cavity and the lower inner cavity in sequence. Apply a downward pressure to the pipetting needle module, so that the slider is squeezed by the upper cleaning base and retracts into the sliding cavity, thereby causing the slider to move upward relative to the pipetting needle until the annular baffle at the bottom of the pipetting needle installation mechanism abuts against the upper surface of the upper cleaning base. At this time, both the first circular seal ring and the second circular seal ring move above the air inlet of the pipetting needle, and the air inlet and the liquid inlet are respectively communicated with the upper air sub-channel and the upper liquid sub-channel; S2. Inject cleaning liquid into the upper liquid sub-channel through the upper distributor, and enter the pipetting needle through the liquid inlet to clean the inner wall of the pipetting needle; Inject cleaning liquid into the lower liquid sub-channel through the lower distributor, and enter the lower cleaning cavity formed by the gap between the pipetting needle and the lower inner cavity to clean the outer wall of the pipetting needle; S3. After the cleaning liquid cleaning is completed, input clean compressed air into the upper air sub-channel through the upper distributor, and enter the pipetting needle through the air inlet to blow and wash the inner wall of the pipetting needle to remove the residual cleaning liquid on the inner wall; Input clean compressed air into the lower air sub-channel through the lower distributor, and enter the lower cleaning cavity formed by the gap between the pipetting needle and the lower inner cavity to blow and wash the outer wall of the pipetting needle to remove the residual cleaning liquid on the outer wall; S4. After the compressed air blowing and washing is completed, remove the pressure applied to the pipetting needle module. Under the elastic force of the spring, the slider moves downward relative to the sliding cavity, so that the slider moves downward relative to the pipetting needle until the sliding part of the slider abuts against the annular baffle. At this time, both the first circular seal ring and the second circular seal ring move to the initial position: the air inlet and the liquid inlet on the pipetting needle are both between the first circular seal ring and the second circular seal ring, and finally the air inlet and the liquid inlet are both closed under the cooperation of the first circular seal ring, the second circular seal ring and the inner wall of the needle hole.

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