A traditional Chinese medicine bacterial enzyme preparation for promoting intestinal health and stress resistance of piglets

Abstract

The application discloses a traditional Chinese medicine bacteria enzyme preparation for promoting intestinal health and stress resistance of piglets, and belongs to the technical field of feed additives. The traditional Chinese medicine bacteria enzyme preparation comprises the following components: compound traditional Chinese medicinal materials, i.e., eucommia ulmoides, astragalus membranaceus, anise, wild chrysanthemum and platycodon grandiflorum; composite enzymes, i.e., cellulase, xylanase and glutamine transaminase; probiotics, i.e., corynebacterium glutamicum, fusing weissella and bacteroide fragilis; base material, i.e., corn flour and soybean meal; intestinal nutrient, i.e., glutamine; and anti-stress preparation, i.e., vitamin C and tryptophan. The compound traditional Chinese medicinal materials, the cellulase, the xylanase and the glutamine transaminase, and the corynebacterium glutamicum are subjected to aerobic fermentation, then the fusing weissella and the bacteroide fragilis are added to perform anaerobic fermentation, finally, the intestinal nutrient and the anti-stress preparation are supplemented, so that the traditional Chinese medicine bacteria enzyme preparation capable of significantly promoting intestinal health and improving stress resistance of weaned piglets is obtained, and an important foundation is laid for health management and efficient production of weaned piglets.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of feed additives, in particular to a traditional Chinese medicine bacteria enzyme preparation for promoting intestinal health and stress resistance of piglets. BACKGROUND

[0002] With the development of pig production towards scale and intensification, in order to improve the productivity of sows and the economic benefits of pig production, early weaning technology of 3-4 weeks old piglets is generally used in production. However, early weaning at 3-4 weeks of age usually causes early weaning stress, leading to diarrhea and growth retardation of piglets within 1-2 weeks after weaning, which has a great impact on pig production. This problem has not been completely solved so far. And post-weaning diarrhea is one of the important reasons affecting the growth performance of piglets and reducing the survival rate of weaned piglets. Post-weaning diarrhea often causes changes in small intestinal morphology and function, damages the digestive and absorptive capacity, and ultimately leads to growth retardation and increased mortality of piglets. The intestinal tract of animals is not only the main place for the digestion and absorption of nutrients, but also an important first barrier for animals. Its health determines the health of the animal body and is closely related to the production level and benefits. Therefore, it is an important task to find an effective preparation for promoting the intestinal health and stress resistance of piglets.

[0003] Traditional Chinese medicine has the characteristics of antibiosis and improvement and regulation of body state, so it has become an important task to maintain and develop pig industry to develop preparations for controlling piglet diarrhea and improving intestinal damage by using the unique traditional Chinese medicine theory and rich plant medicine resources of China. Research has found that the synergistic fermentation of traditional Chinese medicinal materials and probiotic enzymes can release more effective ingredients for use. However, different fermentation strains and enzyme types have a direct impact on the decomposition and utilization efficiency of traditional Chinese medicine and the obtained drug effect. At present, the technology of synergistic fermentation of traditional Chinese medicine by bacteria and enzymes mostly focuses on the release amount of effective ingredients and the probiotic effect of fermented traditional Chinese medicine, often ignoring the flavor and taste of fermented traditional Chinese medicine, resulting in that weaned piglets are not easy to accept, the feed intake decreases, and the probiotic effect cannot be fully played. Therefore, the present application provides a traditional Chinese medicine bacteria enzyme preparation which can effectively promote the intestinal health and stress resistance of piglets, improve the palatability of traditional Chinese medicinal materials, and increase the feed intake of piglets. SUMMARY

[0004] The purpose of the present application is to provide a traditional Chinese medicine bacteria enzyme preparation for promoting the intestinal health and stress resistance of piglets, in order to solve the problems existing in the prior art. The present application uses compound bacteria and enzyme to ferment traditional Chinese medicine, which not only improves the palatability of traditional Chinese medicine preparation, but also obtains antibacterial and immunity-enhancing ingredients, promotes the intestinal health of weaned piglets, and improves their stress resistance, laying an important foundation for the health management and efficient production of weaned piglets.

[0005] To achieve the above purpose, the present application provides the following scheme:

[0006] The application provides a traditional Chinese medicine bacterial enzyme preparation for promoting intestinal health and stress resistance of piglets, which comprises the following components in parts by weight:

[0007] Compound traditional Chinese medicine materials: Eucommia ulmoides 20-40 parts, Astragalus 10-30 parts, Anise 5-30 parts, Wild chrysanthemum 5-20 parts and Platycodon 3-10 parts;

[0008] Compound enzyme: Cellulase 6-10 parts, Xylanase 5-8 parts and Glutamine transaminase 1-2 parts;

[0009] Probiotics: Corynebacterium glutamicum 14-25 parts, Weissella cibaria 15-20 parts and Bacteroides fragilis 15-30 parts;

[0010] Base material: Corn meal 30-60 parts and Soybean meal 20-60 parts;

[0011] Intestinal nutrient agent: Glutamine 6-15 parts;

[0012] Anti-stress agent: Vitamin C 4-10 parts and Tryptophan 1-3 parts.

[0013] Further, the following components in parts by weight are included:

[0014] Compound traditional Chinese medicine materials: Eucommia ulmoides 20 parts, Astragalus 30 parts, Anise 5 parts, Wild chrysanthemum 20 parts and Platycodon 10 parts;

[0015] Compound enzyme: Cellulase 10 parts, Xylanase 8 parts and Glutamine transaminase 1 part;

[0016] Probiotics: Corynebacterium glutamicum 25 parts, Weissella cibaria 20 parts and Bacteroides fragilis 15 parts;

[0017] Base material: Corn meal 60 parts and Soybean meal 20 parts;

[0018] Intestinal nutrient agent: Glutamine 15 parts;

[0019] Anti-stress agent: Vitamin C 8 parts and Tryptophan 3 parts.

[0020] The application also provides a preparation method of the traditional Chinese medicine bacterial enzyme preparation, which comprises the following steps:

[0021] After the compound traditional Chinese medicine materials are pretreated, the materials are mixed with the base material, moisture is adjusted, and high-temperature sterilization is performed;

[0022] Corynebacterium glutamicum is inoculated into the mixture, then the compound enzyme is added into the mixture inoculated with Corynebacterium glutamicum, and aerobic fermentation is performed;

[0023] The mixture after the end of aerobic fermentation is inoculated with the fusobacterium and the bacteroides fragilis, closed, anaerobic fermentation is carried out, and after the fermentation is finished, glutamine, vitamin C and tryptophan are added to obtain the traditional Chinese medicine microbial enzyme preparation.

[0024] Further, the pretreatment of the compound Chinese medicinal material comprises: drying after cleaning, and crushing to 20-50 meshes; and the moisture is adjusted to 65-75 wt%.

[0025] Further, the condition of the aerobic fermentation is: 35-38 DEG C fermentation for 10-18 h.

[0026] Further, the condition of the anaerobic fermentation is: 35-38 DEG C closed fermentation for 2-4 d.

[0027] The application further provides an application of the traditional Chinese medicine microbial enzyme preparation in preparation of a feed additive.

[0028] The application further provides an application of the traditional Chinese medicine microbial enzyme preparation in preparation of a health care product for improving intestinal health and stress resistance of piglets.

[0029] The application further provides a feed for promoting intestinal health and stress resistance of piglets, which comprises an effective dose of the traditional Chinese medicine microbial enzyme preparation.

[0030] Further, the effective dose of the traditional Chinese medicine microbial enzyme preparation is 1-2 wt%.

[0031] The application discloses the following technical effects:

[0032] The application adopts the following steps: compound Chinese medicinal material is subjected to aerobic fermentation together with cellulase, xylanase, glutamine transaminase and coryneform glutamate bacteria, then fusobacterium and bacteroides fragilis are added for anaerobic fermentation, and finally, intestinal nutrition agent glutamine and stress resistance agent vitamin C and tryptophan are supplemented, so that the traditional Chinese medicine microbial enzyme preparation capable of significantly promoting intestinal health and improving stress resistance of weaned piglets is obtained; the compound enzyme is used to cooperate with microbial fermentation, so that the cell wall of the compound Chinese medicinal material can be broken, and the effective components such as stress resistance, anti-inflammatory and antibacterial are released; the glutamine transaminase can improve the absorption characteristics of the protein and other nutritional components in the traditional Chinese medicinal material, improve the palatability of the raw material, and further improve the feed intake and growth rate of piglets.

[0033] Corynebacterium glutamicum can produce sodium glutamate by aerobic fermentation, and the sodium glutamate component can improve the feed intake of piglets, promote the rapid growth and development of piglets, and at the same time, sodium glutamate can also improve the intestinal microecology of piglets and promote the intestinal health; when entering the anaerobic fermentation stage, Corynebacterium glutamicum, Fusobacterium fusiforme and Bacteroides fragilis can all produce metabolic products such as lactic acid and succinic acid, and these acidic components can inhibit harmful bacteria in the gastrointestinal tract of piglets, be beneficial to regulating the gastrointestinal immune response, promote the immune function of gastrointestinal immune cells, reduce the diarrhea and stress of weaned piglets, in addition, the organic acid metabolic products such as lactic acid and succinic acid can increase the flavor and taste of feed, further improve the palatability of the traditional Chinese medicine microbial enzyme preparation, improve the feed intake of piglets, and improve the nutritional value of feed.

[0034] The present application adopts compound microbial enzyme fermentation of traditional Chinese medicine, with the help of microorganisms and enzymes, the effective components in the traditional Chinese medicine prescription are released to the maximum extent, and new active components are added, and the efficacy of traditional Chinese medicinal materials is enhanced; on the other hand, with the help of aerobic and anaerobic batch fermentation, flavor and nutritional components are obtained, the palatability of traditional Chinese medicine preparation is improved, and at the same time, bacteriostatic and immunity enhancing components are obtained, which promote the intestinal health of weaned piglets and improve their stress resistance, and the prepared traditional Chinese medicine microbial enzyme preparation lays an important foundation for the health management and efficient production of weaned piglets. DETAILED DESCRIPTION

[0035] The various illustrative embodiments of the present application will now be described in detail below, which should not be considered as limiting the present application, but should be understood as a more detailed description of certain aspects, characteristics and embodiments of the present application.

[0036] It should be understood that the terms described in the present application are only for describing the specific embodiments, and are not used to limit the present application. In addition, for the numerical range in the present application, it should be understood that each intermediate value between the upper limit and the lower limit of the range is also specifically disclosed. Each smaller range between any stated value or intermediate value in the range, and any other stated value or intermediate value in the range is also included in the present application. The upper limit and the lower limit of these smaller ranges can be independently included or excluded from the range.

[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present application pertains. Although preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present application. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials in connection with which the documents are concerned. In the event of any conflict between the content of this specification and any document incorporated by reference, the content of this specification will control.

[0038] Many modifications and variations to the illustrative embodiments described herein can be practiced by those skilled in the art without departing from the scope or spirit of the present application. Other embodiments of the application will be apparent to those skilled in the art from consideration of the specification and practice of the application disclosed herein. The specification and examples provided should be considered exemplary only.

[0039] As used herein, the terms "comprises", "comprising", "includes", "including", "has", "having" or variants thereof are open-ended, and specifically mean including, but not limited to.

[0040] The Corynebacterium glutamicum used in the present application has a preservation number of CCTCC M 20211507 and is purchased from the China Center for Type Culture Collection, and the bacterial concentration is 1x10 8 The Weissella paramesenteroides has a preservation number of CGMCC NO. 22697 and the Bacteroides fragilis has a preservation number of CGMCC No. 10685, both of which are purchased from the China General Microbiological Culture Collection Center (CGMCC), and the bacterial concentrations are both 1x10 7 cfu / g.

[0041] The cellulase used in the present application has an enzyme activity of 50 U / mg, the xylanase has an enzyme activity of 6000 U / mg, and the glutamine transaminase has an enzyme activity of 200 U / g, all of which are purchased from Shanghai Yuan Ye Biological Technology Co., Ltd.

[0042] The raw materials of the compound traditional Chinese medicine are all purchased from Jicuitang Chinese Herbal Medicine Shop in Taishan District, Taian City, Shandong Province.

[0043] The corn meal, soybean meal, glutamine, vitamin C and tryptophan are all purchased from Shandong Zhongcheng Feedstuff Technology Co., Ltd.

[0044] Example 1

[0045] A traditional Chinese medicine bacterial enzyme preparation for promoting intestinal health and stress resistance of piglets, comprising the following components by weight:

[0046] Compound traditional Chinese medicinal materials: Eucommia ulmoides 24 parts, Astragalus membranaceus 16 parts, Illicium verum 12 parts, wild chrysanthemum 10 parts and Platycodon grandiflorum 3 parts;

[0047] Compound enzymes: cellulase 9 parts, xylanase 5 parts and glutamine transaminase 1 part;

[0048] Probiotics: Corynebacterium glutamicum 14 parts, Weissella paramesenteroides 18 parts and Bacteroides fragilis 23 parts;

[0049] Base material: corn meal 50 parts and soybean meal 40 parts;

[0050] Intestinal nutrient: glutamine 6 parts;

[0051] Stress resistance preparation: vitamin C 10 parts and tryptophan 1 part.

[0052] The preparation method comprises the following steps:

[0053] (1) The compound Chinese medicinal materials are weighed, cleaned, dried, and crushed to 20 meshes. The crushed compound Chinese medicinal materials and the base material weighed according to the proportion are uniformly mixed, the moisture content is adjusted to 65wt%, and high-temperature sterilization is performed at 120℃ for 30min.

[0054] (2) The activated Corynebacterium glutamicum is inoculated into the mixture, and the compound enzyme is added and uniformly mixed according to the proportion. Then aerobic fermentation is performed at 37℃ for 15h.

[0055] (3) The remaining probiotics, i.e., the Weissella cibaria and Bacteroides fragilis, are inoculated into the mixture after aerobic fermentation, and anaerobic fermentation is performed at 37℃ for 3d. Finally, glutamine, vitamin C and tryptophan are added to obtain the Chinese medicinal bacteria enzyme preparation.

[0056] Example 2

[0057] A Chinese medicinal bacteria enzyme preparation for promoting intestinal health and resisting stress of piglets comprises the following components in parts by weight:

[0058] Compound Chinese medicinal materials: Eucommia ulmoides 40 parts, Astragalus membranaceus 10 parts, Illicium verum 30 parts, wild chrysanthemum 5 parts and Platycodon grandiflorum 5 parts;

[0059] Compound enzyme: cellulase 6 parts, xylanase 7 parts and glutamine transaminase 2 parts;

[0060] Probiotics: Corynebacterium glutamicum 20 parts, Weissella cibaria 15 parts and Bacteroides fragilis 30 parts;

[0061] Base material: corn flour 30 parts and soybean meal 60 parts;

[0062] Intestinal nutrient: glutamine 10 parts;

[0063] Stress-resistant preparation: vitamin C 4 parts and tryptophan 2 parts.

[0064] The preparation method comprises the following steps:

[0065] (1) The compound Chinese medicinal materials are weighed, cleaned, dried, and crushed to 50 meshes. The crushed compound Chinese medicinal materials and the base material weighed according to the proportion are uniformly mixed, the moisture content is adjusted to 75wt%, and high-temperature sterilization is performed at 120℃ for 20min.

[0066] (2) The activated Corynebacterium glutamicum is inoculated into the mixture, and the compound enzyme is added and uniformly mixed according to the proportion. Then aerobic fermentation is performed at 37℃ for 10h.

[0067] (3) In the mixture after the aerobic fermentation, the remaining probiotics: Fusobacterium fusiforme and Bacteroides fragilis are inoculated, closed, anaerobic fermentation at 37℃ for 4d, after the end of fermentation, finally add glutamine, vitamin C and tryptophan, to obtain the traditional Chinese medicine bacteria enzyme preparation.

[0068] Example 3

[0069] A traditional Chinese medicine bacteria enzyme preparation for promoting intestinal health and stress resistance of piglets, comprising the following components by weight:

[0070] Compound Chinese medicinal materials: Eucommia ulmoides 20 parts, Astragalus 30 parts, Anise 5 parts, Wild chrysanthemum 20 parts and Platycodon 10 parts;

[0071] Compound enzyme: cellulase 10 parts, xylanase 8 parts and glutamine transaminase 1 part;

[0072] Probiotics: Corynebacterium glutamicum 25 parts, Fusobacterium fusiforme 20 parts, Bacteroides fragilis 15 parts;

[0073] Base material: corn meal 60 parts and soybean meal 20 parts;

[0074] Intestinal nutrient: glutamine 15 parts;

[0075] Anti-stress agent: vitamin C 8 parts and tryptophan 3 parts.

[0076] The preparation method comprises the following steps:

[0077] (1) The compound Chinese medicinal materials are weighed, cleaned and dried, pulverized to 30 mesh, and the pulverized compound Chinese medicinal materials are mixed with the base material weighed according to the proportion, the moisture content is adjusted to 70wt%, and high-temperature sterilization is performed at 110℃ for 40min;

[0078] (2) The activated Corynebacterium glutamicum is inoculated into the above mixture, and the compound enzyme is added and mixed uniformly according to the proportion, and then aerobic fermentation is carried out at 37℃ for 18h.

[0079] (3) In the mixture after the aerobic fermentation, the remaining probiotics: Fusobacterium fusiforme and Bacteroides fragilis are inoculated, closed, anaerobic fermentation at 37℃ for 2d, after the end of fermentation, finally add glutamine, vitamin C and tryptophan, to obtain the traditional Chinese medicine bacteria enzyme preparation.

[0080] Comparative Example 1

[0081] The same as Example 1, the only difference is that the glutamine transaminase in the compound enzyme is adjusted to α-amylase.

[0082] Comparative Example 2

[0083] The same as example 1, the only difference is that the probiotics are: Bacillus subtilis 14 parts, Lactobacillus plantarum 18 parts, Bacteroides fragilis 23 parts.

[0084] Comparative example 3

[0085] The same as example 1, the only difference is that the preparation method comprises the following steps:

[0086] (1) The compound Chinese medicinal materials are weighed, cleaned, dried, and pulverized to 20 mesh. The pulverized compound Chinese medicinal materials are mixed with the base material weighed in proportion, and the moisture content is adjusted to 65wt%. The mixture is sterilized at 120°C for 30 minutes.

[0087] (2) The activated Corynebacterium glutamicum, Weissella paramesenteroides, and Bacteroides fragilis are inoculated into the mixture, and then the compound enzyme is added and mixed in proportion. After that, aerobic fermentation is carried out at 37°C for 3.5 days. Finally, glutamine, vitamin C, and tryptophan are added to obtain the Chinese medicinal bacteria enzyme preparation.

[0088] Comparative example 4

[0089] The same as example 1, the only difference is that the preparation method comprises the following steps:

[0090] (1) The compound Chinese medicinal materials are weighed, cleaned, dried, and pulverized to 20 mesh. The pulverized compound Chinese medicinal materials are mixed with the base material weighed in proportion, and the moisture content is adjusted to 65wt%. The mixture is sterilized at 120°C for 30 minutes.

[0091] (2) The activated Corynebacterium glutamicum, Weissella paramesenteroides, and Bacteroides fragilis are inoculated into the mixture, and then the compound enzyme is added and mixed in proportion. After that, aerobic fermentation is carried out at 37°C for 3.5 days. Finally, glutamine, vitamin C, and tryptophan are added to obtain the Chinese medicinal bacteria enzyme preparation.

[0092] Effect example

[0093] In a pig farm in the suburbs of Taian City, Shandong Province, 400 weaned piglets with similar body weight and similar health status are selected. The 400 piglets are randomly divided into eight groups, namely experimental groups 1-7 and a control group. The experimental groups 1-7 are fed with a basic feed and the Chinese medicinal bacteria enzyme preparations prepared in examples 1-3 and comparative examples 1-4, wherein the addition amount of the Chinese medicinal bacteria enzyme preparation is 2wt% of the basic feed. The control group is only fed with the basic feed. The basic feed for piglet test is configured according to the standard of the United States NRC (2012).

[0094] The piglets were weaned at 21 days and then transferred to a nursery for testing, and the test lasted for 28 days. The pig house, trough, water tank and the like were cleaned and disinfected before the test. The piglets were fed twice a day in the morning and in the afternoon, and the piglets were free to eat and drink water, and the rest of the conventional management and immunization procedures were carried out according to the procedures of the large-scale breeding farm. The test piglets were weighed on an empty stomach at the beginning and end of the test, and the daily feed intake, diarrhea quantity and death quantity of the weaned piglets were recorded every day. After the test, the serum antioxidant indexes of each group were measured, and 6 piglets were slaughtered from each group to measure the gastrointestinal development-related indexes.

[0095] Table 1

[0096]

[0097] As can be seen from the experimental results in Table 1, the experimental groups 1-3 added the traditional Chinese medicine fungus enzyme preparation of Examples 1-3, respectively, which can significantly reduce the diarrhea rate of weaned piglets, increase the feed intake and daily gain, and thus promote the growth and development of weaned piglets and improve their survival rate. The experimental groups 4-7 respectively use the traditional Chinese medicine fungus enzyme preparations prepared by Comparative Examples 1-4, and due to the adjustment of fungus enzyme types and the change of fermentation reaction conditions, the probiotic effect is reduced, which is obviously inferior to the efficacy of the traditional Chinese medicine fungus enzyme preparations prepared by Examples 1-3.

[0098] Table 2

[0099]

[0100] As can be seen from Table 2, the traditional Chinese medicine fungus enzyme preparations prepared by Examples 1-3 of the present application can significantly improve the activities of T-SOD, Cu / Zn SOD, CAT and T-AOC in the serum of piglets, reduce the content of MDA, relieve the weaning stress of piglets, and improve the anti-stress ability of weaned piglets.

[0101] Table 3

[0102]

[0103] As can be seen from Table 3, the traditional Chinese medicine fungus enzyme preparations prepared by Examples 1-3 of the present application can effectively improve the height / depth of the small intestinal villi of weaned piglets, significantly improve the intestinal tissue morphology and digestive and absorptive functions of weaned piglets, and promote intestinal health.

[0104] The above-described examples only describe the preferred modes of the present application, and do not limit the scope of the present application. Without departing from the design spirit of the present application, various modifications and improvements to the technical solutions of the present application made by those skilled in the art shall fall within the protection scope determined by the claims of the present application.

Claims

1. The application of a traditional Chinese medicine bacteria enzyme preparation for promoting intestinal health and stress resistance of piglets in the preparation of health care products for improving intestinal health and stress resistance of piglets, characterized in that, The Chinese medicine fungus enzyme preparation is composed of the following components by weight: Compound Chinese medicinal materials: Eucommia ulmoides 20-40 parts, Astragalus membranaceus 10-30 parts, Illicium verum 5-30 parts, wild chrysanthemum 5-20 parts, and Platycodon grandiflorum 3-10 parts; Compound enzymes: cellulase 6-10 parts, xylanase 5-8 parts, and glutamine transaminase 1-2 parts; Probiotics: Corynebacterium glutamicum 14-25 parts, Weissella cibaria 15-20 parts, and Bacteroides fragilis 15-30 parts; Base material: corn flour 30-60 parts and soybean meal 20-60 parts; Intestinal nutrient: glutamine 6-15 parts; Anti-stress agent: vitamin C 4-10 parts and tryptophan 1-3 parts; The preparation method of the Chinese medicine fungus enzyme preparation comprises the following steps: After pretreatment, the compound Chinese medicinal materials are mixed with the base material, the moisture is adjusted, and high-temperature sterilization is performed; Corynebacterium glutamicum is inoculated into the mixture, and then compound enzymes are added to the mixture inoculated with Corynebacterium glutamicum, and aerobic fermentation is performed; After the aerobic fermentation is completed, Weissella cibaria and Bacteroides fragilis are inoculated into the mixture, which is sealed and subjected to anaerobic fermentation. After the fermentation is completed, glutamine, vitamin C, and tryptophan are added to obtain the Chinese medicine fungus enzyme preparation; The improvement of the intestinal tissue morphology of piglets promotes the intestinal health of piglets; The addition amount of the Chinese medicine fungus enzyme preparation is 2 wt% of the basic feed; The pretreatment of the compound Chinese medicinal materials includes cleaning, drying, and crushing to 20-50 mesh; the moisture is adjusted to 65-75 wt%; The aerobic fermentation conditions are 35-38°C for 10-18 h; The anaerobic fermentation conditions are 35-38°C for 2-4 d.

2. Use according to claim 1, characterized in that, The Chinese medicine fungus enzyme preparation is composed of the following components by weight: Compound Chinese medicinal materials: Eucommia ulmoides 20 parts, Astragalus membranaceus 30 parts, Illicium verum 5 parts, wild chrysanthemum 20 parts, and Platycodon grandiflorum 10 parts; Compound enzymes: cellulase 10 parts, xylanase 8 parts, and glutamine transaminase 1 part; Probiotics: Corynebacterium glutamicum 25 parts, Weissella cibaria 20 parts, and Bacteroides fragilis 15 parts; Base material: corn flour 60 parts and soybean meal 20 parts; Intestinal nutrient: glutamine 15 parts; Anti-stress agent: vitamin C 8 parts and tryptophan 3 parts.

3. Use of the Chinese medicine fungus enzyme preparation as claimed in claim 1 or 2 in the preparation of a feed additive.

4. A feed for promoting intestinal health and stress resistance in piglets, characterized in that, The Chinese medicine fungus enzyme preparation comprises an effective amount of the Chinese medicine fungus enzyme preparation as claimed in claim 1 or 2.

5. The feed according to claim 4, characterized in that, The effective amount of the Chinese medicine fungus enzyme preparation is 2 wt%.

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