Composition for treating acute liver failure and its preparation method

Abstract

The present invention discloses a composition for treating acute liver failure, which is mainly made from a first composition and a second composition; the raw materials of the first composition include: Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma Recens, Poria, Polygonati Rhizoma, Corni Fructus, Bupleuri Radix, Curcumae Radix, Artemisiae Scopariae Herba, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, Prunellae Spica, Nitrum, Alum, Rhizoma Curcumae Zedoariae, Persicae Semen, Endoconcha Galli, Lygodii Spora; and the raw materials of the second composition include: Concha Ostreae, Carapax Trionycis. The present invention takes clearing heat and detoxifying, tonifying deficiency and purging excess, softening hardness and dissipating stasis, promoting blood circulation to remove blood stasis as the main line, supplemented by products for soothing the liver and strengthening the spleen, promoting diuresis and clearing heat; it has the effects of enhancing the body's immunity, anti-infection, promoting albumin synthesis and hepatocyte regeneration of hepatocytes, anticoagulation and antifibrinolysis, preventing the formation of post-hepatitis cirrhosis and liver cancer, and has good therapeutic effects on acute liver failure without toxic side effects.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a composition for treating acute liver failure and a preparation method thereof. Background Art

[0002] Acute liver failure refers to a clinical syndrome in which the liver undergoes severe functional impairment within a short period of time due to various reasons, unable to maintain normal metabolic and detoxification functions, thereby leading to multiple organ dysfunction throughout the body. It is a serious life-threatening liver disease. Acute liver failure usually occurs in an otherwise healthy liver, rather than in patients with chronic liver disease. Its onset process is relatively fast, and obvious liver function abnormalities and multiple organ damage throughout the body usually appear within a few days to a few weeks. Common causes include drug or poison poisoning, viral infections (such as hepatitis B virus, hepatitis E virus), acute hepatitis, autoimmune hepatitis, hepatic vein obstruction, etc. The characteristics of its disease progression mainly include the following aspects: Rapid deterioration: Liver function rapidly deteriorates within a short period of time, which can lead to multiple organ failure. Severe liver function disorders: Manifested as jaundice, abnormal coagulation function, hypoproteinemia, etc. Neurological symptoms: Due to liver function impairment, toxic substances such as ammonia accumulate in the body, leading to neurological damage. Patients may experience changes in mental state, consciousness disorders, coma, etc. Multiple organ dysfunction syndrome (MODS): Acute liver failure can cause damage to the functions of other organs, such as the heart, lungs, kidneys and other organs are involved. High mortality rate: If not intervened and treated in a timely manner, its mortality rate is relatively high.

[0003] Acute liver failure is a critical disease that requires timely treatment to save lives. Modern treatment methods for acute liver failure include the following aspects: 1. Supportive treatment: Patients with acute liver failure need to receive close monitoring and supportive treatment in an intensive care unit or intensive care unit. This includes maintaining respiratory function, stabilizing the circulatory status, correcting electrolyte disorders, and providing nutritional support. 2. Drug treatment: Drug treatment is used to improve liver function, reduce inflammatory responses, and control infections. For example, antiviral drugs are given to treat acute liver failure caused by viral hepatitis; adrenal corticosteroids are used to reduce the inflammatory response caused by autoimmune hepatitis; anti-infective drugs are applied to combat bacterial infections, etc. 3. Liver transplantation: For patients with severe acute liver failure, liver transplantation may be the only treatment option. Liver transplantation can replace the damaged liver and restore normal liver function. However, liver transplantation surgery has certain risks and requires a suitable donor and sufficient preoperative evaluation. 4. Artificial liver support system: The artificial liver support system is a technology that filters and metabolizes waste products and maintains blood homeostasis, which can provide temporary support during the waiting period for liver transplantation or the recovery of liver function. It can help reduce the burden on the liver and protect other organs from the damage of toxic substances. 5. Other treatment measures: Depending on the specific situation, other treatment measures may also be adopted, such as plasma exchange, coagulation factor supplementation, vitamin supplementation, correction of acid-base balance disorders, etc.

[0004] The etiological and pathological mechanisms of acute liver failure are complex, and the condition changes rapidly. If the condition is effectively controlled, the condition will progress favorably or slowly, such as the decline of transaminase and bilirubin, the stability of albumin and platelets, no risk of gastrointestinal bleeding, no tendency to develop cirrhosis, no complications such as hepatic encephalopathy, and the mortality rate is controlled. Although the existing treatment technologies and means have been improved, clinically, there are still situations where the condition progresses in the opposite direction, which are manifested as high death risk, long overall course of disease, high treatment costs, etc. Through research, it is found that these problems are closely related to the body's own immunity, the intensity of inflammation control, and the synthesis and regeneration function of hepatocytes. Therefore, solving these current problems has always been the focus and task of our exploration and research.

[0005] The information disclosed in this background art section is only intended to increase the understanding of the overall background of the present invention and should not be regarded as an admission or any form of implication that this information constitutes the prior art already known to those of ordinary skill in the art. Summary of the Invention

[0006] The purpose of the present invention is to provide a composition for treating acute liver failure. The composition for treating acute liver failure is made of a variety of traditional Chinese medicines, which can effectively cure, reverse, and improve acute liver failure without toxic or side effects.

[0007] Another purpose of the present invention is to provide a preparation method of the composition for treating acute liver failure.

[0008] To achieve the above object, the present invention provides a composition for treating acute liver failure, which is mainly made of a first composition and a second composition;

[0009] The raw materials of the first composition include: Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma Recens, Poria, Polygonati Rhizoma, Corni Fructus, Bupleuri Radix, Curcumae Radix, Artemisiae Scopariae Herba, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, Prunellae Spica, Nitrum, Alum, Rhizoma Curcumae, Persicae Semen, Endoconcha Galli, Lygodii Spora; and

[0010] The raw materials of the second composition include: Concha Ostreae and Carapax Trionycis.

[0011] Preferably, in the above technical solution, for the composition for treating acute liver failure, by weight, the raw materials of the first composition include: 10-30 parts of Scrophulariae Radix, 10-30 parts of Atractylodis Macrocephalae Rhizoma, 6-12 parts of Zingiberis Rhizoma Recens, 10-20 parts of Poria, 10-20 parts of Polygonati Rhizoma, 10-20 parts of Corni Fructus, 9-12 parts of Bupleuri Radix, 10-20 parts of Curcumae Radix, 10-40 parts of Artemisiae Scopariae Herba, 10-20 parts of Magnoliae Officinalis Cortex, 6-12 parts of Rhei Radix et Rhizoma, 6-12 parts of Prunellae Spica, 9-12 parts of Nitrum, 9-12 parts of Alum, 9-12 parts of Rhizoma Curcumae, 9-12 parts of Persicae Semen, 10-30 parts of Endoconcha Galli, 9-12 parts of Lygodii Spora.

[0012] Preferably, in the above technical solution, for the composition for treating acute liver failure, by weight, the raw materials of the second composition include: 10-30 parts of Concha Ostreae and 10-30 parts of Carapax Trionycis.

[0013] Preferably, in the above technical solution, for the composition for treating acute liver failure,

[0014] by weight, the raw materials of the first composition include: 20 parts of Scrophulariae Radix, 20 parts of Atractylodis Macrocephalae Rhizoma, 9 parts of Zingiberis Rhizoma Recens, 15 parts of Poria, 15 parts of Polygonati Rhizoma, 15 parts of Corni Fructus, 10 parts of Bupleuri Radix, 15 parts of Curcumae Radix, 25 parts of Artemisiae Scopariae Herba, 15 parts of Magnoliae Officinalis Cortex, 9 parts of Rhei Radix et Rhizoma, 9 parts of Prunellae Spica, 10 parts of Nitrum, 10 parts of Alum, 10 parts of Rhizoma Curcumae, 10 parts of Persicae Semen, 20 parts of Endoconcha Galli, 10 parts of Lygodii Spora;

[0015] The raw materials of the second composition include: 20 parts of Concha Ostreae and 20 parts of Carapax Trionycis.

[0016] The present application also provides a preparation method of a composition for treating acute liver failure, comprising the following steps:

[0017] (1) Prepare the first composition: Weigh Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma Recens, Poria, Polygonati Rhizoma, Corni Fructus, Bupleuri Radix, Curcumae Radix, Artemisiae Scopariae Herba, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, Prunellae Spica, Nitri Kalii, Alum, Rhizoma Curcumae Zedoariae, Persicae Semen, Endoconcha Galli, Lygodii Spora according to the weight ratio, put them together into a gauze bag and then into a container. Add cold water to the container and soak for 30 - 60 minutes to obtain mixture A for standby.

[0018] (2) Prepare the second composition: Break Ostreae Concha and Amydae Carapax into pieces and decoct them first. Immerse the pieces in a casserole filled with cold water and boil with boiling water for 30 minutes to obtain mixture B for standby.

[0019] (3) Place mixture A and mixture B from step (1) and step (2) together in a casserole and decoct them jointly. During this period, do not add or subtract the water in the container again. Boil with strong fire for 5 - 10 minutes and then change to slow fire and continue to boil for 30 - 60 minutes to obtain the medicinal liquid.

[0020] Preferably, in the above technical solution, the medicinal liquid can be directly filtered and divided into ceramic bowls at 200 ml per bowl, and taken warm three times a day in the morning, noon and evening. Or it can be divided into bags at 200 ml per bag using an instrument device. When using, it needs to be boiled and then taken warm. In special cases (such as gastrointestinal bleeding, coma without a gastric tube, etc.), retention enema is carried out.

[0021] The pharmacological mechanisms of the drug raw materials used in the present invention are as follows:

[0022] Scrophulariae Radix: Nature and flavor: Slightly cold in nature, sweet, bitter and salty in taste; Efficacy and function: It has the effects of cooling blood and nourishing yin, purging fire and detoxifying. It is used for symptoms such as injury of yin due to febrile disease, crimson tongue and vexatious thirst, epidemic toxin maculae, constipation due to fluid impairment, consumptive fever with bone steaming, red eyes, sore throat, scrofula, diphtheria, carbuncles and sores; Pharmacological effect: Scrophulariae Radix can lower blood sugar. It has certain effects of reducing blood pressure, strengthening the heart, dilating blood vessels and inhibiting dermatophytes. It also has sedative, anti - convulsive and antipyretic effects. The ethanol extract can increase coronary blood flow and enhance the ability to tolerate hypoxia.

[0023] Atractylodis Macrocephalae Rhizoma: Warm in nature, sweet and bitter in taste, with the effects of strengthening the spleen and stomach, increasing appetite, stopping spontaneous sweating, sedation, etc. It can be used to treat symptoms such as weakness of the spleen and stomach, loss of appetite, lassitude, diarrhea, phlegm retention, edema, dysuria, dizziness, spontaneous sweating, fetal restlessness, etc. In addition, Atractylodis Macrocephalae Rhizoma can accelerate blood circulation, lower blood sugar, make gastric and intestinal secretion exuberant and intestinal peristalsis enhanced. Moreover, it can prevent the reduction of liver glycogen and has a protective effect on the liver.

[0024] Zingiberis Rhizoma Recens: Pungent in taste, hot in nature. It belongs to the spleen, stomach, kidney, heart and lung meridians. It warms the middle - jiao and dispels cold, restores yang and unblocks the meridians, warms the lungs and resolves fluid retention. It is mainly used for epigastric and abdominal cold pain, vomiting and diarrhea, cold limbs and weak pulse, cold fluid - retention and cough.

[0025] Poria cocos: It has a neutral nature and enters the spleen meridian. Drinking it soaked in water can play a role in strengthening the spleen and has a certain conditioning effect on symptoms such as poor appetite due to spleen deficiency, loose stools, etc. Secondly, Poria cocos enters the heart meridian and also has the effect of calming the mind, being able to relieve symptoms such as palpitations, insomnia, and restlessness of the mind, and is helpful for improving sleep quality. In addition, drinking Poria cocos soaked in water has the effect of promoting diuresis and removing dampness, and can relieve symptoms such as edema with scanty urine and dysuria.

[0026] Polygonatum sibiricum: It has a sweet taste, a neutral nature, and is non-toxic. Its main effects are to replenish middle qi, benefit the spleen and moisten the lungs, and dispel wind-dampness. It is better to eat Polygonatum sibiricum after steaming and drying it nine times. Some people also think that eating Polygonatum sibiricum can prolong life.

[0027] Cornus officinalis: Nature and flavor: sour and astringent in taste, slightly warm in nature; meridian tropism: entering the liver and kidney meridians, used for dizziness and tinnitus, soreness and weakness of the waist and knees, impotence and spermatorrhea, enuresis and frequent urination, metrorrhagia and leukorrhea, profuse sweating and collapse, internal heat and thirst.

[0028] Bupleurum chinense: It enters the liver meridian and has the effect of soothing the liver and relieving depression, and has a certain conditioning effect on symptoms such as chest and hypochondrium distending pain, irregular menstruation, emotional depression, breast distending pain, etc. Bupleurum chinense is slightly cold in nature and can also play a role in reducing fever, being able to relieve the fever caused by diseases such as acute bronchitis, acute tracheitis, and viral pneumonia. In addition, Bupleurum chinense has the effect of tonifying yang and can improve symptoms such as qi deficiency and organ prolapse. Pharmacological studies show that Bupleurum chinense has sedative and analgesic effects and can also protect the liver and reduce liver damage.

[0029] Curcuma aromatica Salisb.: Nature and flavor: pungent, bitter, and cold in taste; meridian tropism: entering the liver, lung, and heart meridians; effects: promoting blood circulation to relieve pain, regulating qi to relieve depression, clearing the heart and cooling blood, promoting bile secretion and reducing jaundice. Used for chest and hypochondrium stabbing pain, angina pectoris, amenorrhea and dysmenorrhea, breast distending pain, coma due to febrile diseases, epilepsy and mania, hematemesis and epistaxis due to blood heat, jaundice with dark urine.

[0030] Artemisia capillaris Thunb.: Bitter and pungent in taste, slightly cold in nature, entering the spleen, stomach, liver, and gallbladder meridians, being able to relieve symptoms such as damp-warm syndrome, summer dampness, and itching of eczema, and can also improve diseases such as jaundice with scanty urine, hepatitis, and liver cirrhosis, and can promote the recovery of the condition.

[0031] Magnolia officinalis Rehd. et Wils.: Bitter, pungent, and warm in nature. Spleen meridian; Stomach meridian; Large Intestine meridian. Promoting qi flow to eliminate stagnation; drying dampness and relieving fullness; descending adverse qi and relieving asthma. Food retention and qi stagnation; abdominal distension and constipation; dampness obstructing the middle energizer, fullness and stuffiness in the epigastrium with vomiting and diarrhea; phlegm congestion and qi reversal; chest fullness and asthma cough.

[0032] Rheum palmatum L.: Nature and flavor: bitter and cold; purging excessive heat, breaking stagnation, promoting blood circulation. Used for the treatment of: intestinal obstruction due to ascariasis in children, flatulence, acute upper gastrointestinal bleeding, scalds and burns, hyperlipidemia, acute suppurative tonsillitis, chyluria, paronychia, neurodermatitis, soft tissue contusion and strain, recurrent aphthous ulcers, acute mastitis, nipple cracks, tinea manus, superficial thrombophlebitis, chronic prostatitis, pustular herpes.

[0033] Prunella vulgaris: Flavor and nature: pungent, bitter, cold. Meridians entered: liver and gallbladder meridians; Efficacy: clearing the liver and purging fire, improving eyesight, dissipating binds and relieving swelling. Indications: for red and swollen eyes, pain in the eyes at night, headache and dizziness, scrofula, goiter, breast abscess, breast nodulation, breast distending pain.

[0034] Niter: Bitter and salty in flavor, warm in nature, entering the heart, spleen and lung meridians. Indications: boils and sores, red eyes, sore throat, dysuria with pain, jaundice, cholera with sunstroke and distension, abdominal pain, etc. It has the effects of attacking toxins and relieving swelling, promoting diuresis and purging, and breaking up firmness and dispersing accumulation.

[0035] Alum: Flavor and nature: sour, astringent, cold in nature, entering the lung, spleen, liver and large intestine meridians; Efficacy: externally, detoxifying and killing parasites, drying dampness and relieving itching; internally, stopping bleeding and diarrhea, expelling wind-phlegm; externally used for eczema, scabies, rectal prolapse, hemorrhoids, otorrhea; internally used for chronic diarrhea, hematochezia, metrorrhagia, epilepsy and mania. Indications: burnt alum arrests discharge and promotes granulation, stops bleeding and promotes tissue generation. For eczema and damp sores, rectal prolapse, hemorrhoids, otorrhea, leukorrhagia with vulval pruritus, epistaxis and gingival bleeding, nasal polyp.

[0036] Zedoary: Bitter and pungent in flavor, warm in nature, non-toxic. Indications: qi and blood stasis, distending pain in the heart and abdomen, mass in the abdomen, accumulation, indigestion of retained food, blood stasis and amenorrhea in women, pain caused by traumatic injury.

[0037] Peach kernel: Flavor and nature: bitter, sweet, flat; Entering the heart, liver and large intestine meridians; Efficacy: promoting blood circulation to remove blood stasis, moistening the intestine and relieving constipation, relieving cough and asthma; Indications: for amenorrhea and dysmenorrhea, mass in the abdomen, lung abscess and intestinal abscess, traumatic injury, intestinal dryness and constipation, cough and asthma.

[0038] Endothelium corneum gigeriae galli: Flavor and nature: sweet, flat; Entering the spleen, stomach, small intestine and bladder meridians; Efficacy: promoting digestion, astringing essence and arresting seminal emission, removing calculus and promoting diuresis; Indications: for indigestion, vomiting and diarrhea, infantile malnutrition, enuresis, spermatorrhea, stranguria with pain, pain in the hypochondrium due to gallbladder distension.

[0039] Lygodium japonicum: Sweet, cold, non-toxic. Indications: promoting diuresis in the small intestine, treating mania due to typhoid fever, treating swelling and toxin caused by damp-heat, stranguria with pain, gonorrhea with turbid discharge, hematuria, calculus stranguria, menstrual pain, relieving heat-toxin.

[0040] Compared with the prior art, the present invention has the following beneficial effects:

[0041] (1) The composition of the present invention for treating acute liver failure. Among them, Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma Recens, and Poriae Cocos are attributed to the lung, spleen, kidney, and stomach meridians, and have the effects of nourishing yin and clearing heat, replenishing qi and strengthening the spleen, warming the middle energizer to consolidate the root, and transforming dampness to generate qi; Polygonati Rhizoma and Corni Fructus are sweet and warm in nature, sour for astringing and tonifying, tonifying the liver and kidney, astringing essence and arresting sweating, and tonifying the mother to generate the son to prevent the exhaustion of normal body fluids; Bupleuri Radix, Curcumae Radix, and Artemisiae Scopariae Herba soothe the liver and relieve depression, promote bile drainage and reduce jaundice. When the wood is easy to dredge, the earth will be soft and not firm, so that the damp-heat and turbid pathogens can seep out to the river channel and flow out of the lower energizer outside the body; Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, and Prunellae Spica lower qi to soothe the middle energizer, eliminate food stagnation and promote digestion, purge heat and reduce jaundice, disperse stagnation and resolve phlegm to remove the intestinal feces, so as not to cause biliary stasis; Ostreae Concha, Nitrum, and Alum are attributed to the liver, gallbladder, and kidney meridians, salty for dispersing stagnation, clearing heat and detoxifying, and strengthening yin and dispersing stagnation. Modern research shows that potassium nitrate and potassium alum dodecahydrate have anti-infective effects, with a broad-spectrum inhibitory effect on viruses and anti-intestinal negative bacteria; Trionycis Carapax, Rhizoma Curcumae, and Persicae Semen are attributed to the heart, liver, and kidney meridians, and have the effects of nourishing yin and suppressing yang, removing fever and relieving hectic fever, softening hardness and dissipating stagnation, promoting blood circulation and removing blood stasis, etc. The liver stores blood. Promoting blood circulation and removing blood stasis can prevent the aggravation of liver blood stasis and the occurrence of large liver necrosis, and at the same time has anticoagulant and antifibrinolytic effects; Gallus Galli Endothelium Corneum and Lygodii Sporae Semen promote digestion and remove stasis, promote diuresis and relieve stranguria, to remove the stasis of urine in the lower energizer, keep the urethra unobstructed to ensure that bilirubin and inflammation in the blood can be smoothly excreted outside the body; Trionycis Carapax, Gallus Galli Endothelium Corneum, Ostreae Concha, etc. provide a large amount of amino acids, which can supply the liver to synthesize proteins to maintain the body's metabolic needs, and at the same time increase the body's immunity and promote the self-synthesis of hepatocytes; Atractylodis Macrocephalae Rhizoma, Scrophulariae Radix, Polygonati Rhizoma, and Corni Fructus can increase the body's disease resistance, enhance the body's immunity, and promote the body's self-repair; Prunellae Spica, Scrophulariae Radix, Trionycis Carapax, and Rhizoma Curcumae have anti-tumor effects. During the use process, they can resist liver fibrosis, prevent the progression of diseases such as liver cirrhosis or liver cancer; Artemisiae Scopariae Herba, Bupleuri Radix, and Gallus Galli Endothelium Corneum have antibacterial effects, can inhibit the regeneration of gastrointestinal bacteria, and can also inhibit the replication and reproduction of liver viruses, playing a role in protecting the liver.

[0042] (2) The composition of the present invention for treating acute liver failure takes clearing heat and detoxifying, tonifying deficiency and purging excess, softening hardness and dissipating stagnation, and promoting blood circulation and removing blood stasis as the main line, supplemented by herbs for soothing the liver and strengthening the spleen, promoting diuresis and purging heat; it has the effects of improving the body's immunity, anti-infection, promoting the synthesis of albumin by hepatocytes and hepatocyte regeneration, anticoagulation and antifibrinolysis, preventing the formation of post-hepatitis cirrhosis and liver cancer, with good effects in treating acute liver failure and no toxic side effects. Detailed implementation mode

[0043] The following will describe the specific implementation mode of the present invention in detail in combination with specific embodiments. However, it should be understood that the protection scope of the present invention is not limited by the specific implementation mode.

[0044] The following diagnostic criteria, basis for formula selection, clinical evaluation time, and examples can help those skilled in the art to more comprehensively understand the present invention, but cannot limit the present invention in any way.

[0045] I. Definition description

[0046] (1) Acute liver failure (ALF) refers to liver failure that presents acutely, without a history of underlying liver disease, and is characterized by grade II or higher hepatic encephalopathy within 2 weeks, according to the criteria of the "2018 Edition of the Guidelines for Liver Failure". The pathological manifestation is a one-time necrosis of hepatocytes, which can be massive or sub-massive necrosis, or bridging necrosis, accompanied by severe degeneration of surviving hepatocytes and collapse or partial collapse of the hepatic sinusoidal reticular framework.

[0047] (2) Diagnostic criteria for acute liver failure: Acute onset, with grade II or higher hepatic encephalopathy (classified according to the IV-grade classification method) occurring within 2 weeks and presenting the following manifestations:

[0048] 1) Extreme fatigue, accompanied by severe digestive tract symptoms such as obvious anorexia, abdominal distension, nausea, and vomiting;

[0049] 2) Progressive deepening of jaundice in the short term, with serum total bilirubin (TBIL) ≥ 10 × the upper limit of normal value (ULN) or rising ≥ 17.1 μmol / L per day;

[0050] 3) Tendency to bleed, with prothrombin activity (PTA) ≤ 40%, or international normalized ratio (INR) ≥ 1.5, and other causes excluded;

[0051] 4) Progressive shrinkage of the liver.

[0052] (3) Clinical symptoms as the basis for formula selection: 1) Jaundice of the whole body skin and mucosa (mainly the sclera) can be divided into bright yellow and dark yellow; 2) Yellow urine; 3) Lethargy, dry mouth, bitter taste in the mouth, fatigue, anorexia, abdominal distension, nausea, and vomiting; 4) Diarrhea can be divided into ≥ 5 times / day and < 5 times / day; 5) Yellow and thick greasy tongue coating or black and thick greasy tongue coating, thin white tongue coating; 6) Full pulse or weak pulse.

[0053] (4) The clinical assessment starts from the next day after using traditional Chinese medicine for symptom assessment, such as whether there are changes in urine volume and urine color, whether there are changes in constipation or diarrhea frequency of stools, whether there are changes in consciousness and skin and mucosal bleeding points or evidence of gastrointestinal bleeding; at the same time, starting from the next day of medication, serum indicators, coagulation, blood routine, urine routine, stool routine and other indicators can be rechecked 3 days later to evaluate the disease progression, and the corresponding indicators as mentioned above can be rechecked 3 days later (equivalent to 1 week after using the composition) to adjust the medication.

[0054] II. Description of Examples

[0055] Example 1

[0056] (1) Basis for using Example 1: 1) Jaundice of the whole body skin and mucosa (mainly the sclera) can be divided into bright yellow or dark yellow; 2) Yellow urine; 3) Lethargy, dry mouth, bitter taste in the mouth, fatigue, anorexia, abdominal distension, nausea, and vomiting; 4) Diarrhea can be divided into diarrhea ≥ 5 times per day; 5) Thin white tongue coating; 6) Weak pulse;

[0057] (2) Example 1: The composition for treating acute liver failure is mainly made up of a first composition and a second composition. Among them, calculated by weight parts, the raw materials of the first composition include: 10 parts of Scrophulariae Radix, 10 parts of Atractylodis Macrocephalae Rhizoma, 12 parts of Zingiberis Rhizoma Recens, 10 parts of Poria, 10 parts of Polygonati Rhizoma, 10 parts of Corni Fructus, 9 parts of Bupleuri Radix, 10 parts of Curcumae Radix, 10 parts of Artemisiae Capillaris Herba, 10 parts of Magnoliae Officinalis Cortex, 6 parts of Rhei Radix et Rhizoma, 6 parts of Prunellae Spica, 9 parts of Nitrum, 9 parts of Alum, 9 parts of Rhizoma Curcumae, 9 parts of Persicae Semen, 10 parts of Endoconcha Galli, 9 parts of Lygodii Spora.

[0058] Calculated by weight parts, the raw materials of the second composition include: 10 parts of Concha Ostreae and 20 parts of Carapax Trionycis.

[0059] The preparation method of the above composition includes the following steps:

[0060] (1) Prepare the first composition: Weigh Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma Recens, Poria, Polygonati Rhizoma, Corni Fructus, Bupleuri Radix, Curcumae Radix, Artemisiae Capillaris Herba, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, Prunellae Spica, Nitrum, Alum, Rhizoma Curcumae, Persicae Semen, Endoconcha Galli, and Lygodii Spora according to the weight ratio, put them into a gauze bag together and then put them into a container. Add cold water to the container and soak for 30 - 60 minutes to obtain mixture A for standby.

[0061] (2) Prepare the second composition: Break Concha Ostreae and Carapax Trionycis and decoct them first. Immerse the fragments in a casserole filled with cold water and boil with boiling water for 30 minutes to obtain mixture B for standby.

[0062] (3) Place mixture A and mixture B obtained in step (1) and step (2) together in a casserole and decoct them together. During this period, do not add or subtract the water in the container again. Boil over high heat for 5 - 10 minutes and then change to low heat and continue to boil for 30 - 60 minutes to obtain the medicinal liquid.

[0063] The composition for treating acute liver failure of the present invention is a liquid preparation. The usage method is to directly filter and divide the medicinal liquid into ceramic bowls at 200 ml per bowl and take it warm three times a day, morning, noon, and evening, or divide it into bags at 200 ml per bag using an instrument device and take it warm after boiling when using.

[0064] Example 2

[0065] (1) Basis for using Example 2: 1) Jaundice of the whole body skin and mucosa (mainly the sclera) can be divided into bright yellow or dull yellow; 2) Yellow urine; 3) Lassitude, dry mouth, bitter taste in the mouth, fatigue, anorexia, abdominal distension, nausea, vomiting; 4) Diarrhea can be divided into <5 times a day; 5) Yellow and thick greasy tongue coating or black and thick greasy tongue coating; 6) Full pulse.

[0066] (2) Example 2 The composition for treating acute liver failure is mainly made up of a first composition and a second composition: Among them, by weight parts, the raw materials of the first composition include: 30 parts of Scrophulariae Radix, 30 parts of Atractylodis Macrocephalae Rhizoma, 6 parts of Zingiberis Rhizoma Recens, 20 parts of Poria, 20 parts of Polygonati Rhizoma, 20 parts of Corni Fructus, 12 parts of Bupleuri Radix, 20 parts of Curcumae Radix, 40 parts of Artemisiae Capillaris Herba, 20 parts of Magnoliae Officinalis Cortex, 12 parts of Rhei Radix et Rhizoma, 12 parts of Prunellae Spica, 12 parts of Nitrum, 12 parts of Alum, 12 parts of Curcumae Rhizoma, 12 parts of Persicae Semen, 30 parts of Galli Gigerii Endothelium Corneum, 12 parts of Lygodii Spora

[0067] By weight parts, the raw materials of the second composition include: 30 parts of Ostreae Concha, 30 parts of Amydae Carapax.

[0068] The preparation method of the above composition for treating acute liver failure is the same as that of Example 1.

[0069] Example 3

[0070] (1) Basis for using Example 3: 1) Jaundice of the whole body skin and mucous membranes (mainly the sclera) can be divided into bright yellow and dull yellow; 2) Yellow urine; 3) Lassitude, dry mouth, bitter taste in the mouth, fatigue, anorexia, abdominal distension, nausea, vomiting; 4) Diarrhea can be divided into ≥5 times / day and <5 times / day; 5) Yellow and thick greasy tongue coating or black and thick greasy tongue coating, thin white tongue coating; 6) Full pulse or deficient pulse

[0071] (2) The composition for treating acute liver failure in Example 3 mainly includes a first composition and a second composition. Among them, by weight parts, the raw materials of the first composition include: 30 parts of Scrophulariae Radix, 30 parts of Atractylodis Macrocephalae Rhizoma, 6 parts of Zingiberis Rhizoma Recens, 20 parts of Poria, 10 parts of Polygonati Rhizoma, 20 parts of Corni Fructus, 12 parts of Bupleuri Radix, 10 parts of Curcumae Radix, 30 parts of Artemisiae Capillaris Herba, 10 parts of Magnoliae Officinalis Cortex, 6 parts of Rhei Radix et Rhizoma, 6 parts of Prunellae Spica, 9 parts of Nitrum, 9 parts of Alum, 12 parts of Curcumae Rhizoma, 9 parts of Persicae Semen, 30 parts of Galli Gigerii Endothelium Corneum, 9 parts of Lygodii Spora

[0072] By weight parts, the raw materials of the second composition include: 30 parts of Ostreae Concha, 30 parts of Amydae Carapax.

[0073] The manufacturing method of the above composition for treating acute liver failure is the same as the steps in Example 1.

[0074] In the present invention, Example 4 is also disclosed. Example 4 discloses a composition for treating acute liver failure, including a first composition and a second composition. Among them, by weight parts, the raw materials of the first composition include: 20 parts of Scrophulariae Radix, 20 parts of Atractylodis Macrocephalae Rhizoma, 9 parts of Zingiberis Rhizoma Recens, 15 parts of Poria, 15 parts of Polygonati Rhizoma, 15 parts of Corni Fructus, 10 parts of Bupleuri Radix, 15 parts of Curcumae Radix, 25 parts of Artemisiae Capillaris Herba, 15 parts of Magnoliae Officinalis Cortex, 9 parts of Rhei Radix et Rhizoma, 9 parts of Prunellae Spica, 10 parts of Nitrum, 10 parts of Alum, 10 parts of Curcumae Rhizoma, 10 parts of Persicae Semen, 20 parts of Galli Gigerii Endothelium Corneum, 10 parts of Lygodii Spora.

[0075] By weight parts, the raw materials of the second composition include: 20 parts of oyster and 20 parts of turtle shell.

[0076] In the present invention, Example 5 is also disclosed. Example 5 discloses a composition for treating acute liver failure, which includes a first composition and a second composition. Among them, by weight parts, the raw materials of the first composition include: 15 parts of scrophularia, 15 parts of atractylodes macrocephala, 9 parts of dried ginger, 12 parts of poria cocos, 12 parts of polygonatum sibiricum, 12 parts of cornel, 10 parts of bupleurum, 12 parts of curcuma aromatica, 20 parts of artemisia capillaris, 12 parts of magnolia officinalis, 9 parts of rhubarb, 9 parts of prunella vulgaris, 10 parts of nitre, 10 parts of alum, 10 parts of zedoary, 10 parts of peach kernel, 20 parts of chicken's gizzard-membrane, and 10 parts of lygodium japonicum.

[0077] By weight parts, the raw materials of the second composition include: 18 parts of oyster and 18 parts of turtle shell.

[0078] III. Adjustment Instructions

[0079] Condition assessment and composition adjustment after using the composition for acute liver failure for 1 week:

[0080] (1) Adjustment basis: 1) Presence or absence of abdominal distension and diarrhea (defined as more than 5 bowel movements per day); 2) Presence or absence of scattered petechiae on the skin and mucous membranes or gastrointestinal bleeding; 3) Whether bilirubin decreases or continues to rise; 4) Whether there is thrombocytopenia and whether cholinesterase continues to decline;

[0081] (2) Specific adjustment methods:

[0082] 1) If there is abdominal distension and diarrhea, remove oyster, nitre, alum, and rhubarb in all examples, and keep the other medications unchanged. After continuing for 1 week, evaluate and adjust, or the doctor may make other adjustments;

[0083] 2) If there are scattered petechiae on the skin and mucous membranes or gastrointestinal bleeding (except for urethral bleeding), remove turtle shell and zedoary in all examples, and keep the other medications unchanged. After continuing for 1 week, evaluate and adjust, or the doctor may make other adjustments;

[0084] 3) If bilirubin continues to rise, use the highest amounts of rhubarb and artemisia capillaris within the reference range of the composition for acute liver failure (except for the minimum amount of rhubarb due to diarrhea according to item 54);

[0085] 4) If thrombocytopenia continues and cholinesterase continues to decline, adjust by removing oyster, nitre, alum, and rhubarb in all examples in the same way as for abdominal distension and diarrhea, and keep the other medications unchanged. After continuing for 1 week, evaluate and adjust, or the doctor may make other adjustments.

[0086] IV. Experimental Examples

[0087] (1) Randomly select 98 inpatients in the hepatology department of the hospital who meet the inclusion criteria under the condition of no liver source (details are shown in Table 1), code them according to the order of hospitalization, and randomly divide them into groups A, B, C, and D. Group A uses the composition for treating acute liver failure in Example 1 combined with comprehensive treatment; Group B uses the composition for treating acute liver failure in Example 2 combined with comprehensive treatment; Group C uses the composition for treating acute liver failure in Example 3 combined with comprehensive treatment; Group D uses the comprehensive treatment in the example. The above comprehensive treatment measures can be referred to the following description in detail:

[0088] 1) If caused by viral infection: antiviral treatment; 2) If caused by alcohol consumption: immediately stop drinking; 3) If caused by a certain drug: immediately block the intake of the drug; 4) If caused by autoimmunity: after rest, anti-immune or immune-enhancing drugs can be used according to the situation; 5) If the transaminase is abnormally increased: liver-protecting and enzyme-lowering drugs can be used; 6) If combined with gastrointestinal symptoms: gastric-protecting and gastric mucosa-protecting drugs can be used; 7) If the bilirubin is abnormally increased: cholagogic and jaundice-reducing drugs can be used; 8) If the coagulation mechanism is abnormal: coagulation factors or plasma can be supplemented; 9) If the albumin is abnormally low: human albumin can be supplemented; 10) If combined with gastrointestinal bleeding or (and) defecation: hemostasis, blood transfusion or enema can be performed; 11) If combined with hepatic encephalopathy: treatment with ammonia-lowering measures and oxygen inhalation can be carried out; 12) If there is evidence of hypoxia: oxygen supplementation treatment, hemostasis, blood transfusion or enema can be performed; 13) If already fasting or (and) abstaining from drinking: vitamins, amino acids, and fat emulsion can be supplemented; 14) If combined with ascites: diuresis can be considered.

[0089] Table 1 Basic information, diagnosis, grouping and comprehensive treatment plan of patients

[0090]

[0091]

[0092]

[0093]

[0094]

[0095]

[0096] (2) All groups were compared at admission and 1 week after hospitalization. Cases terminated due to the reasons of the service objects themselves during the process were excluded. The observation indicators included neutrophil percentage (NEUT%), lymphocyte count (LYM), hemoglobin amount (HGB), platelet (PLT), international standard value of coagulation function (INR), transaminase (ALT, AST), total bilirubin (TB), albumin (ALB), serum potassium ion (K), and serum sodium ion (Na).

[0097] (3) Data statistical analysis: Variables that follow a normal distribution are expressed as mean ± standard deviation (SD), and those that do not follow a normal distribution are expressed as median and interquartile range. One-way analysis of variance and between-group comparison or non-parametric test (KWH) test were used respectively. All statistical analyses were performed using IBM SPSS Statistics version 21. P < 0.05 was considered to indicate that there were statistically significant differences in the corresponding variables between all corresponding treatment groups and group D.

[0098] The details of the comparison results of each example group after 1 week are shown in Table 2 and Table 3:

[0099] Table 3 Comparison of each variable before and 1 week after admission treatment in each group

[0100]

[0101]

[0102] Table 3 Results of pairwise comparison of each variable between groups after 1 week of treatment

[0103]

[0104]

[0105]

[0106] * The significance level of the mean difference is 0.05.

[0107] As can be seen from Table 2, after 1 week of treatment, the NEUT of patients in groups A, B, C, and D improved compared with that at admission. And through the comparison in Table 3, it can be known that there were significant differences between groups A, B, and C and group D, further indicating that the combined treatment of the composition for acute liver failure and comprehensive treatment had a significant effect compared with simple comprehensive treatment. Thus, it can be seen that the composition for acute liver failure had a good effect on inflammation control during the treatment of acute liver failure.

[0108] As can be seen from Table 2, after 1 week of treatment, the LYM of patients in groups A, B, and C improved compared with that at admission, while the LYM of patients in group D decreased compared with that at admission. Moreover, through comparison in Table 3, it can be known that there were significant differences between groups A, B, and C and group D, further indicating that the combined treatment of the composition for acute liver failure and comprehensive treatment had significantly better curative effects than simple comprehensive treatment. Thus, it can be seen that the composition for acute liver failure had a good effect on lymphocyte recovery during the treatment of acute liver failure.

[0109] As can be seen from Table 2, after 1 week of treatment, the INR of patients in groups A, B, C, and D improved compared with that at admission. Moreover, through comparison in Table 3, it can be known that there were significant differences between groups A, B, and C and group D, further indicating that the combined treatment of the composition for acute liver failure and comprehensive treatment had significantly better curative effects than simple comprehensive treatment. Thus, it can be seen that the composition for acute liver failure had a good effect on coagulation function recovery during the treatment of acute liver failure.

[0110] As can be seen from Table 2, after 1 week of treatment, the ALB of patients in groups A and C improved compared with that at admission, while the ALB of patients in groups B and D decreased compared with that at admission. However, the ALB fluctuation of patients in group B tended to be stable compared with that in group D. Moreover, through comparison in Table 3, it can be known that there were significant differences between groups A, B, and C and group D, further indicating that the combined treatment of the composition for acute liver failure and comprehensive treatment had significantly better curative effects than simple comprehensive treatment. Thus, it can be seen that the composition for acute liver failure had a good effect on albumin elevation during the treatment of acute liver failure.

[0111] As can be seen from Table 2, after 1 week of treatment, H of each treatment group decreased compared with that at admission. Although the differences between groups were not significant, whether there was clinical combined gastrointestinal bleeding still required data support. From the variable platelets, it can be known that the platelets in the simple comprehensive treatment group decreased compared with those before treatment, and whether there was a trend of combined liver cirrhosis in the cases still required corresponding evidence support, but it indicated poor prognosis. From the variables bilirubin and transaminases, it can be known that the treatment effects of each group improved compared with those before treatment, and the differences were not significant.

[0112] In summary, the composition of the present invention for acute liver failure had good effects such as protecting the liver, anti-infection, controlling inflammation, restoring the body's immunity, restoring hepatocyte albumin synthesis, preventing liver cirrhosis, hepatic encephalopathy, reducing "toxicity" and enhancing efficacy, etc., had obvious anti-acute liver failure effects, and could significantly improve the acute liver failure indicators. Moreover, the composition for the treatment of acute liver failure had the advantages of rapid onset, high safety, simple technical operation, rich drug sources, wide application scope, etc., and was suitable for popularization and application.

[0113] This disease is caused by external pathogens, dietary damage, spleen and stomach deficiency and cold, and accumulation and transformation. Its pathogenesis is that dampness blocks the middle jiao or blood stasis blocks the bile duct, so that bile does not follow the normal path and overflows on the skin and turns yellow. As the disease progresses, there may be bleeding, fatigue, atrophy, and even severe symptoms such as abdominal distension, fever, bleeding, and coma. According to records, according to the symptoms and characteristics of acute liver failure, it belongs to the category of jaundice in traditional Chinese medicine. In the early stage, it is divided into Yang jaundice and Yin jaundice. It is treated according to the degree of dampness, heat and blood stasis. In the late stage, the disease may progress to bloating or death, that is, the current category of cirrhosis and hepatic encephalopathy.

[0114] The present invention focuses on starting with dampness, heat and blood stasis, clearing away heat and dampness, promoting blood circulation and removing blood stasis, supporting yin and yang, and curing the disease and strengthening the foundation throughout, and prepares a composition for treating acute liver failure according to the law.

[0115] Typical Cases

[0116] He, 52 years old. Was admitted to the hospital for "fatigue, yellow body, and yellow urine for 5 days". There was no history of hepatotropic virus infection or blood transfusion. The patient had a history of fatigue and staying up late before the onset of the disease. When he felt weak and rested at home, he noticed that his skin was yellow and his urine was yellow. He thought he was overworked, but there was no improvement after rest. For a clear diagnosis and treatment, the patient was examined and found that his eyes were yellow, his body was yellow, his tongue was old, his tongue coating was thick and greasy, and his pulse was slippery and rapid. The white blood cell percentage was 73.4%, lymphocytes were 0.52X 109 / L, total bilirubin was 511.2umol / L, INR was 1.66, and albumin was 32.8g / L. Ultrasound showed no ascites, hepatomegaly, or dilatation of the bile duct. Example 2 After one week of treatment, fatigue improved, yellow body and urine were relieved, and the percentage of white blood cells was 66.4%, lymphocytes were 1.52X 109 / L, total bilirubin was 311.2umol / L, INR was 1.06, and albumin was 33.2g / L. Ultrasound showed no ascites, hepatomegaly, and bile duct dilatation.

[0117] Duan, female, was admitted to the hospital for "fatigue and nausea for 1 week". One week before admission, she took cold medicine orally after catching a cold, and came to the hospital for treatment due to fatigue and nausea. Physical examination showed yellow skin and mucous membranes, yellow sclera, pale and fat tongue, thin white fur, and slippery pulse. The white blood cell percentage was 55.2%, lymphocytes were 0.38X 109 / L, total bilirubin was 211.7umol / L, INR was 1.75, and albumin was 35.9g / L. Ultrasound was performed to improve the absence of ascites, hepatomegaly, and bile duct dilatation. Example 1 After 1 week of treatment, fatigue improved, yellow body and yellow urine were reduced, and the white blood cell percentage was 61.4%, lymphocytes were 2.12X 109 / L, total bilirubin was 114.2umol / L, INR was 0.63, and albumin was 43.7g / L. Ultrasound was performed to improve the absence of ascites, hepatomegaly, and bile duct dilatation.

[0118] The foregoing description of the specific exemplary embodiments of the present invention is for purposes of illustration and exemplification. These descriptions are not intended to limit the invention to the precise forms disclosed, and it is apparent that many modifications and variations are possible in light of the above teachings. The purpose of selecting and describing the exemplary embodiments is to explain the specific principles of the present invention and its practical applications, so that those skilled in the art can implement and utilize the various different exemplary embodiments of the present invention, as well as various different selections and modifications. The scope of the present invention is intended to be defined by the claims and their equivalents.

Claims

1. A composition for treating acute liver failure, characterized in that, it is made from a first composition and a second composition; The raw materials of the first composition are composed of Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma Recens, Poria, Polygonati Rhizoma, Corni Fructus, Bupleuri Radix, Curcumae Radix, Artemisiae Scopariae Herba, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, Prunellae Spica, Nitri Kalii, Aluminii Sulfas, Rhizoma Curcumae, Persicae Semen, Endoconcha Galli, Lygodii Spora; by weight parts, Scrophulariae Radix 10 - 30 parts, Atractylodis Macrocephalae Rhizoma 10 - 30 parts, Zingiberis Rhizoma Recens 6 - 12 parts, Poria 10 - 20 parts, Polygonati Rhizoma 10 - 20 parts, Corni Fructus 10 - 20 parts, Bupleuri Radix 9 - 12 parts, Curcumae Radix 10 - 20 parts, Artemisiae Scopariae Herba 10 - 40 parts, Magnoliae Officinalis Cortex 10 - 20 parts, Rhei Radix et Rhizoma 6 - 12 parts, Prunellae Spica 6 - 12 parts, Nitri Kalii 9 - 12 parts, Aluminii Sulfas 9 - 12 parts, Rhizoma Curcumae 9 - 12 parts, Persicae Semen 9 - 12 parts, Endoconcha Galli 10 - 30 parts, Lygodii Spora 9 - 12 parts; and The raw materials of the second composition are composed of Concha Ostreae and Carapax Trionycis, by weight parts, Concha Ostreae 10 - 30 parts, Carapax Trionycis 10 - 30 parts.

2. The composition for treating acute liver failure according to claim 1, characterized in that, by weight parts, the raw materials of the first composition are composed of Scrophulariae Radix 10 parts, Atractylodis Macrocephalae Rhizoma 10 parts, Zingiberis Rhizoma Recens 12 parts, Poria 10 parts, Polygonati Rhizoma 10 parts, Corni Fructus 10 parts, Bupleuri Radix 9 parts, Curcumae Radix 10 parts, Artemisiae Scopariae Herba 10 parts, Magnoliae Officinalis Cortex 10 parts, Rhei Radix et Rhizoma 6 parts, Prunellae Spica 6 parts, Nitri Kalii 9 parts, Aluminii Sulfas 9 parts, Rhizoma Curcumae 9 parts, Persicae Semen 9 parts, Endoconcha Galli 10 parts, Lygodii Spora 9 parts; by weight parts, the raw materials of the second composition are composed of Concha Ostreae 10 parts and Carapax Trionycis 20 parts.

3. The composition for treating acute liver failure according to claim 1, characterized in that, by weight parts, the raw materials of the first composition are composed of Scrophulariae Radix 30 parts, Atractylodis Macrocephalae Rhizoma 30 parts, Zingiberis Rhizoma Recens 6 parts, Poria 20 parts, Polygonati Rhizoma 20 parts, Corni Fructus 20 parts, Bupleuri Radix 12 parts, Curcumae Radix 20 parts, Artemisiae Scopariae Herba 40 parts, Magnoliae Officinalis Cortex 20 parts, Rhei Radix et Rhizoma 12 parts, Prunellae Spica 12 parts, Nitri Kalii 12 parts, Aluminii Sulfas 12 parts, Rhizoma Curcumae 12 parts, Persicae Semen 12 parts, Endoconcha Galli 30 parts, Lygodii Spora 12 parts; by weight parts, the raw materials of the second composition are composed of Concha Ostreae 30 parts and Carapax Trionycis 30 parts.

4. The composition for treating acute liver failure according to claim 1, characterized in that, by weight parts, the raw materials of the first composition are composed of Scrophulariae Radix 30 parts, Atractylodis Macrocephalae Rhizoma 30 parts, Zingiberis Rhizoma Recens 6 parts, Poria 20 parts, Polygonati Rhizoma 10 parts, Corni Fructus 20 parts, Bupleuri Radix 12 parts, Curcumae Radix 10 parts, Artemisiae Scopariae Herba 30 parts, Magnoliae Officinalis Cortex 10 parts, Rhei Radix et Rhizoma 6 parts, Prunellae Spica 6 parts, Nitri Kalii 9 parts, Aluminii Sulfas 9 parts, Rhizoma Curcumae 12 parts, Persicae Semen 9 parts, Endoconcha Galli 30 parts, Lygodii Spora 9 parts; by weight parts, the raw materials of the second composition are composed of Concha Ostreae 30 parts and Carapax Trionycis 30 parts.

5. A preparation method of the composition for treating acute liver failure according to any one of claims 1 - 4, characterized in that, it includes the following steps: (1)Prepare the first composition: Weigh Scrophulariae Radix, Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma, Poria, Polygonati Rhizoma, Corni Fructus, Bupleuri Radix, Curcumae Radix, Artemisiae Scopariae Herba, Magnoliae Officinalis Cortex, Rhei Radix et Rhizoma, Prunellae Spica, Nitri Kalii, Albumentum, Curcumae Rhizoma, Persicae Semen, Endoconcha Galli, Lygodii Spora according to the weight ratio, put them together into a gauze bag and then into a container. Add cold water to the container and soak for 30 - 60 minutes to obtain mixture A for standby; (2)Prepare the second composition: Smash Ostreae Concha and Trionycis Carapax and decoct them first. Immerse the fragments in a casserole filled with cold water and boil with boiling water for 30 minutes to obtain mixture B for standby; (3)Put mixture A and mixture B in steps (1) and (2) together in a casserole and decoct them together. During this process, do not add or subtract the water in the container again. Boil with strong fire for 5 - 10 minutes and then change to slow fire and continue to boil for 30 - 60 minutes to obtain the medicinal liquid.

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