A burn and scald ointment, its preparation method and application

Abstract

The application discloses a burn and scald ointment, which comprises the following components in parts by mass: 10-20 parts of radix harmel, 5-15 parts of gardenia, 1-5 parts of ox gall, 3-8 pieces of centipede, 1-3 parts of musk, 5-15 parts of smilax, 5-15 parts of buckwheat, 5-10 parts of coptis, 25-35 parts of oyster shell, 3-8 parts of amber, 5-15 parts of catechu, 3-8 parts of borneol, 5-15 parts of radix scrophulariae, 5-15 parts of bletilla, and 3-8 parts of beeswax. The burn and scald ointment has the effects of clearing heat and resolving toxin, cooling blood and removing stasis, removing corruption and promoting tissue regeneration, and relieving pain, and is suitable for various burn and scald injuries, such as water scald, gasoline, sulfuric acid, and gunpowder burn, pitch burn, lime, cement, and electric shock injury. After use, the burn and scald ointment has good effect, and I-II degree recovery only leaves slight scar.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a burn and scald ointment and a preparation method and application thereof. BACKGROUND

[0002] The western medicine treatment of burn and scald is mainly painkillers and local antibacterial drugs, such as silver sulfadiazine, the curative effect is significant, but there are some obvious side effects, and the ability to promote skin tissue regeneration is poor. The effect of treating edema after burn is also not ideal, and wound infection is one of the common complications of burn and scald. Taking silver sulfadiazine as an example, it can cause neutropenia, aplastic anemia and other reactions after being absorbed into the blood.

[0003] In recent years, traditional Chinese medicine has been increasingly favored in the treatment of burn and scald. Compared with western medicine, Chinese herbal medicine has significant advantages in promoting tissue regeneration, and has the characteristics of rich preparation types, low safety and toxicity, low price and the like. SUMMARY

[0004] In view of the above prior art, the purpose of the present application is to provide a burn and scald ointment and a preparation method and application thereof.

[0005] To achieve the above-mentioned purpose, the technical scheme adopted by the present application is as follows:

[0006] The first aspect of the present application provides a burn and scald ointment, which comprises the following components in mass fraction: 10-20 parts of Sanguisorba officinalis, 5-15 parts of Gardenia jasminoides, 1-5 parts of ox gall, 3-8 pieces of Solenopsis geminata, 1-3 parts of musk, 5-15 parts of Smilax china, 5-15 parts of Fagopyrum esculentum, 5-10 parts of Coptis chinensis, 25-35 parts of Oolong, 3-8 parts of amber, 5-15 parts of catechu, 3-8 parts of borneol, 5-15 parts of Scutellaria baicalensis, 5-15 parts of Bletilla striata, and 3-8 parts of beeswax.

[0007] As a preferred embodiment, the burn and scald ointment comprises the following components in mass fraction: 15 parts of Sanguisorba officinalis, 10 parts of Gardenia jasminoides, 3 parts of ox gall, 5 pieces of Solenopsis geminata, 2 parts of musk, 10 parts of Smilax china, 10 parts of Fagopyrum esculentum, 8 parts of Coptis chinensis, 30 parts of Oolong, 5 parts of amber, 10 parts of catechu, 5 parts of borneol, 10 parts of Scutellaria baicalensis, 10 parts of Bletilla striata, and 6 parts of beeswax.

[0008] The second aspect of the present application provides a preparation method of the above-mentioned burn and scald ointment, which comprises the following steps:

[0009] (1) uniformly mixing Sanguisorba officinalis, Smilax china, Coptis chinensis and Scutellaria baicalensis to obtain a mixture, adding water to the mixture, heating and extracting, and filtering to obtain a filtrate;

[0010] (2) adding crushed ox gall, Solenopsis geminata, Oolong, amber, Bletilla striata, Gardenia jasminoides, musk, Fagopyrum esculentum, catechu, borneol and beeswax to the filtrate, heating and concentrating to obtain an extract, and naturally cooling the extract to obtain the burn and scald ointment.

[0011] Preferably, in step (1), the water added is 8-12 times the mass of the mixture, the heating temperature is 80-90℃, and the heating time is 4-5 hours.

[0012] Preferably, in step (2), the particle size of the pulverized material is 20 mesh, the heating temperature is 70-80℃, and the heating time is 10-15 hours.

[0013] The second aspect of the present invention provides the use of the above-mentioned burn ointment in the preparation of a medicine for treating burns and scalds.

[0014] The burn ointment of this invention has the effects of clearing heat and detoxifying, cooling blood and dispersing blood stasis, removing necrotic tissue and promoting tissue regeneration, and relieving pain. It is suitable for various burns such as water burns, gasoline, sulfuric acid, gunpowder burns, asphalt burns, lime, cement, and electric shock burns. After use, it can relieve pain quickly and has a good effect. After first- and second-degree burns heal, only slight scars are left.

[0015] Sanguisorba officinalis: It has the effects of stopping bleeding and cooling blood, clearing heat and detoxifying, astringing and stopping diarrhea, and inhibiting a variety of pathogenic microorganisms and tumors. It can be used to treat burns.

[0016] Gardenia: Clears heat and relieves irritability, promotes diuresis and eliminates dampness, cools the blood and detoxifies; used externally to reduce swelling and relieve pain. Used for feverish irritability, damp-heat jaundice, painful urination, hematemesis and epistaxis due to blood heat, red and swollen eyes, carbuncles and sores caused by fire toxins, and externally for sprains and contusions.

[0017] Calculus bezoar: Clears the heart, resolves phlegm, opens the orifices, cools the liver, calms wind, and detoxifies. Used for delirium due to fever, phlegm-induced coma due to stroke, convulsions, epilepsy, sore throat, mouth and tongue sores, carbuncles, boils, and furuncles.

[0018] Centipede: It has the effects of calming wind and relieving spasms, clearing the meridians and relieving pain, and attacking toxins and dispersing nodules. Centipede is pungent and warm, and its nature is good at penetrating and reaching both the inside and outside of the body. It has a strong ability to dispel wind and calm convulsions, making it an essential medicine for calming wind and relieving spasms. Centipede is poisonous, and its taste is pungent and dispersing. It has the nature of penetrating and can use poison to fight poison. It has the effects of detoxifying, dispersing nodules, reducing swelling and relieving pain.

[0019] Musk: It can open the orifices and refresh the mind, promote blood circulation and regulate menstruation, and reduce swelling and relieve pain. For sores, carbuncles, scrofula, and sore throat: This product is pungent and aromatic, and has a good effect of promoting blood circulation, dispersing nodules, reducing swelling and relieving pain. It is effective for treating the above symptoms, whether taken internally or applied externally.

[0020] Smilax china: dispels wind and dampness, promotes urination, and reduces swelling and toxins. It is used to treat joint pain, muscle numbness, diarrhea, dysentery, edema, gonorrhea, boils, carbuncles, scrofula, and hemorrhoids.

[0021] Buckwheat: It stimulates appetite, relieves intestinal congestion, and eliminates bloating. It treats intestinal colic, gastrointestinal stagnation, chronic diarrhea, dysentery with aphasia, erysipelas, carbuncles, scrofula, and burns.

[0022] Coptis: clear heat and dry dampness, purge fire and detoxify. Used for damp-heat distention, vomiting and acid regurgitation, diarrhea, jaundice, high fever and convulsions, heart fire, insomnia, blood heat, nosebleed, red eyes, toothache, diabetes, carbuncle and sore.

[0023] Oyster shell: calm the heart and mind, calm the liver and suppress yang, astringe and contract. Used for palpitation, insomnia, epilepsy, dizziness, self-sweating, hematuria, incontinence, prolonged diarrhea, prolonged ulcer and wet skin.

[0024] Amber: calm the heart and mind, remove blood stasis and stop bleeding, promote water and relieve stranguria. Treat convulsions, insomnia, stranguria, hematuria, and other conditions.

[0025] Catechu: has the effects of promoting blood circulation, stopping pain, promoting blood circulation, astringing and clearing heat and reducing phlegm. Used for trauma, external hemorrhage, hemoptysis, sore and wet skin, lung heat and cough.

[0026] Borneol: clear and dispel, has the effects of opening the orifices, clearing heat and dispelling toxins, and clearing the eyes. Used for high fever and convulsions, wind-stroke, phlegm-stroke, heat-stroke, dizziness, sore throat, deafness, mouth sores, tooth swelling, sore, hemorrhoids, red eyes, and cataract.

[0027] Scutellaria: clear heat and dry dampness, purge fire and detoxify, stop bleeding and calm the fetus. Used for damp-heat distention, chest stuffiness and vomiting, diarrhea, jaundice, lung heat and cough, high fever and thirst, blood heat and nosebleed, carbuncle and sore, and unstable fetus.

[0028] Bletilla: bitter, sweet and astringent, slightly cold, belongs to the lung, liver and stomach channels. Bletilla is used to stop bleeding and reduce swelling.

[0029] Beeswax: detoxifies, astringes, promotes tissue regeneration and relieves pain. Used for ulcer, sore, external trauma, burns and scalds.

[0030] The burn and scald ointment of the present application follows the compatibility principle of monarch, minister, assistant and messenger. The monarch herbs are Sanguisorba officinalis, Coptis, Smilax china and Scutellaria; the minister herbs are ox gall, oyster shell, amber, bletilla and centipede; the monarch herbs, the minister herbs, the assistant herbs and the messenger herbs have a synergistic effect, and have the effects of clearing heat and detoxifying, cooling blood and removing blood stasis, removing necrotic tissue and promoting tissue regeneration, and relieving pain.

[0031] The present application has the following advantages:

[0032] The burn and scald ointment of the present application has the effects of clearing heat and detoxifying, cooling blood and removing blood stasis, removing necrotic tissue and promoting tissue regeneration, and relieving pain, and is suitable for various burns and scalds such as water scald, gasoline, sulfuric acid, gunpowder burn, asphalt burn, lime, cement, electric shock and the like. After use, the pain is relieved quickly, the effect is good, and after recovery, only slight scars are left.

[0033] The burn and scald ointment of the present application follows the compatibility principle of monarch, minister, assistant and messenger. The monarch is Sanguisorba officinalis, Coptis chinensis, Smilax riparia and Scutellaria baicalensis; the minister is ox gall, dragon bone, amber, Bletilla striata and centipede; the monarch, minister, assistant and messenger have synergistic effect, and have the effects of clearing heat and resolving toxin, cooling blood and removing stasis, removing corruption and promoting tissue regeneration, and relieving pain. DETAILED DESCRIPTION

[0034] It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the present application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0035] As described in the background, although the western medicine has significant effect, it has some obvious toxic side effects, and has poor ability to promote skin tissue regeneration, and has complications such as wound infection; compared with western medicine, Chinese herbal medicine has significant advantages in promoting tissue regeneration, and has characteristics such as rich preparation type, low safety and toxicity, and low price.

[0036] The present inventors combine years of clinical experience in burn and scald treatment and the dialectical theory of traditional Chinese medicine, follow the compatibility principle of monarch, minister, assistant and messenger, and screen and match Chinese herbal medicines, and obtain that the monarch used in the composition is Sanguisorba officinalis, Coptis chinensis, Smilax riparia and Scutellaria baicalensis, and the minister is ox gall, dragon bone, amber, Bletilla striata and centipede.

[0037] The present application provides a burn and scald ointment, which comprises the following components in parts by mass: Sanguisorba officinalis 10-20 parts, Gardenia jasminoides 5-15 parts, ox gall 1-5 parts, centipede 3-8 pieces, musk 1-3 parts, Smilax riparia 5-15 parts, buckwheat 5-15 parts, Coptis chinensis 5-10 parts, dragon bone 25-35 parts, amber 3-8 parts, catechu 5-15 parts, borneol 3-8 parts, Scutellaria baicalensis 5-15 parts, Bletilla striata 5-15 parts, and beeswax 3-8 parts.

[0038] The preparation method of the burn and scald ointment described above comprises the following steps:

[0039] (1) uniformly mixing Sanguisorba officinalis, Smilax riparia, Coptis chinensis and Scutellaria baicalensis to obtain a mixture, adding water in an amount of 8-12 times the mass of the mixture, heating at 80-90 ℃ for 4-5 hours for extraction, and filtering to obtain a filtrate;

[0040] (2) adding crushed ox gall, centipede, dragon bone, amber, Bletilla striata, Gardenia jasminoides, musk, buckwheat, catechu, borneol and beeswax to the filtrate, heating at 70-80 ℃ for 10-15 hours for concentration, obtaining an extract, and naturally cooling the extract to obtain the burn and scald ointment.

[0041] In order for those skilled in the art to more clearly understand the technical solutions of the present application, the technical solutions of the present application will be described in detail below in conjunction with specific examples.

[0042] The test materials used in the embodiments of the present application are all conventional test materials in the art and can be purchased through commercial channels.

[0043] Example 1

[0044] A burn and scald ointment, comprising the following components: 15g of Sanguisorba officinalis, 10g of Gardenia jasminoides, 3g of ox gall, 5 pieces of centipede, 2g of musk, 10g of Smilax china, 10g of buckwheat, 8g of Coptis chinensis, 30g of oyster shell, 5g of amber, 10g of catechu, 5g of borneol, 10g of Scutellaria baicalensis, 10g of Bletilla striata, and 6g of beeswax.

[0045] A preparation method, comprising the following steps:

[0046] (1) mixing Sanguisorba officinalis, Smilax china, Coptis chinensis, and Scutellaria baicalensis uniformly to obtain a mixture, adding water with a mass of 10 times that of the mixture to the mixture, heating at 90°C for 4 hours for extraction, and filtering to obtain a filtrate;

[0047] (2) adding crushed ox gall, centipede, oyster shell, amber, Bletilla striata, Gardenia jasminoides, musk, buckwheat, catechu, borneol, and beeswax with a mesh size of 20 mesh to the filtrate, heating at 80°C for 12 hours for concentration, obtaining an extract, and naturally cooling the extract to obtain the burn and scald ointment.

[0048] Example 2

[0049] A burn and scald ointment, comprising the following components: 10g of Sanguisorba officinalis, 5g of Gardenia jasminoides, 1g of ox gall, 3 pieces of centipede, 1g of musk, 5g of Smilax china, 5g of buckwheat, 5g of Coptis chinensis, 25g of oyster shell, 3g of amber, 5g of catechu, 3g of borneol, 5g of Scutellaria baicalensis, 5g of Bletilla striata, and 3g of beeswax.

[0050] A preparation method, comprising the following steps:

[0051] (1) mixing Sanguisorba officinalis, Smilax china, Coptis chinensis, and Scutellaria baicalensis uniformly to obtain a mixture, adding water with a mass of 10 times that of the mixture to the mixture, heating at 90°C for 4 hours for extraction, and filtering to obtain a filtrate;

[0052] (2) adding crushed ox gall, centipede, oyster shell, amber, Bletilla striata, Gardenia jasminoides, musk, buckwheat, catechu, borneol, and beeswax with a mesh size of 20 mesh to the filtrate, heating at 80°C for 12 hours for concentration, obtaining an extract, and naturally cooling the extract to obtain the burn and scald ointment.

[0053] Example 3

[0054] A burn and scald ointment, comprising the following components: 20g of Sanguisorba officinalis, 15g of Gardenia jasminoides, 5g of ox gall, 8 pieces of centipede, 3g of musk, 15g of Smilax china, 15g of buckwheat, 10g of Coptis chinensis, 35g of oyster shell, 8g of amber, 15g of catechu, 8g of borneol, 15g of Scutellaria baicalensis, 15g of Bletilla striata, and 8g of beeswax.

[0055] A preparation method, comprising the following steps:

[0056] (1) Mix Ulmus pumila, Smilax china, Coptis chinensis, and Scutellaria baicalensis to obtain a mixture, add water with a mass of 10 times that of the mixture to the mixture, heat at 90℃ for 4 hours to extract, and filter to obtain a filtrate;

[0057] (2) Add crushed ox gall, centipede, oyster shell, amber, Bletilla striata, Gardenia jasminoides, musk, buckwheat, catechu, borneol, and beeswax to the filtrate, heat at 80℃ for 12 hours to concentrate, obtain an extract, and naturally cool the extract to obtain the burn and scald ointment.

[0058] Comparative Example 1

[0059] A burn and scald ointment, comprising the following components: Ulmus pumila 15g, Smilax china 10g, Coptis chinensis 8g, and Scutellaria baicalensis 10g.

[0060] A preparation method, comprising the following steps:

[0061] (1) Mix Ulmus pumila, Smilax china, Coptis chinensis, and Scutellaria baicalensis to obtain a mixture, add water with a mass of 10 times that of the mixture to the mixture, heat at 90℃ for 4 hours to extract, and filter to obtain a filtrate;

[0062] (2) Heat the filtrate at 80℃ for 12 hours to concentrate, obtain an extract, and naturally cool the extract to obtain the burn and scald ointment.

[0063] Compared with Example 1, the present comparative example only has monarch drugs.

[0064] Comparative Example 2

[0065] A burn and scald ointment, comprising the following components: ox gall 3g, centipede 5, oyster shell 30g, amber 5g, and Bletilla striata 10g.

[0066] A preparation method, comprising the following steps:

[0067] (1) Crush ox gall, centipede, oyster shell, amber, and Bletilla striata to 20 mesh, add water with a mass of 10 times that of the mixture to the mixture, heat at 90℃ for 4 hours to extract, and filter to obtain a filtrate;

[0068] (2) Heat the filtrate at 80℃ for 12 hours to concentrate, obtain an extract, and naturally cool the extract to obtain the burn and scald ointment.

[0069] Compared with Example 1, the present comparative example only has ministerial drugs.

[0070] Comparative Example 3

[0071] A burn and scald ointment, comprising the following components: Gardenia jasminoides 10g, musk 2g, buckwheat 10g, catechu 10g, borneol 5g, and beeswax 6g.

[0072] A preparation method, comprising the following steps:

[0073] (1) Gardenia, musk, buckwheat, catechu, borneol, beeswax are crushed to 20 mesh, 10 times the mass of water is added, heated at 90°C for 4 hours to extract, and the filtrate is obtained by filtration;

[0074] (2) The filtrate is heated at 80°C for 12 hours to obtain an extract, and the extract is naturally cooled and dried to obtain a powder.

[0075] Compared with Example 1, the present comparative example only has adjuvants and drugs.

[0076] Experimental Example

[0077] 1. The burn and scald ointment prepared in Example 1 is used to treat the scalded area, and the treatment case is as follows:

[0078] Patient 1, female, 42 years old, scalded lower leg by boiling water, scalded area showed redness and blister formation, diagnosed as superficial II degree scald, after debridement, the burn and scald ointment of the present application was applied, the dressing was changed 3 times a day for the first 2 days, and then once a day, the scalded area recovered after 5 days of medication, without leaving scars.

[0079] Patient 2, male, 10 years old, scalded arm by hot oil, scalded area showed white, skin peeling, and a large amount of yellow liquid oozing from the wound surface, diagnosed as deep II degree scald, after washing with normal saline, the burn and scald ointment of the present application was applied, the dressing was changed 3 times a day for the first 3 days, and then 2 times a day, new granulation tissue was formed on the 3rd day of medication, and the scalded area recovered after 12 days of medication, without leaving scars.

[0080] Patient 3, male, 35 years old, severely burned by fire, with scalded areas on the back and arms, showing blackened skin and a foul odor, diagnosed as III degree scald, after washing with normal saline, the burn and scald ointment of the present application was applied, the dressing was changed 5 times a day, new granulation tissue was formed on the 7th day of medication, and the scalded area recovered after 20 days of medication, without leaving scars.

[0081] 2. Mouse scalding experiment

[0082] According to the steps of Chapter 4, Section 2.3, Mouse Scalding Activity Experiment, in the literature "Research on Effective Substances Derived from Classic Famous Formula Yuhong Ointment and Treatment of Scalding" (Shen Yingxin, Changchun University of Chinese Medicine, 2022), the experiment was conducted by a commissioned experimental institution. The mice used were purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd.

[0083] 2.1 Establishment of mouse scalding model

[0084] At 24h before the experiment, the mice were depilated on the back with an appropriate amount of 5% sodium sulfide liquid, and the hairless area on the back of the mice was about 2x2 cm. When the scald model was established, a 50g weight was placed in boiling water for 10 min, then quickly taken out and tightly adhered to the smooth hairless skin of the mice for 8s to complete the deep II degree scald model. The blank control group was not treated.

[0085] 2.2 Skin healing rate

[0086] 50 mice were divided into 5 groups, and the burn and scald ointments of Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 3 were used for treatment. The mice were depilated on the back with 5% sodium sulfide, and the area was 2x2 cm. The skin on the back of the mice was tightly placed on the weight in distilled water, and the time was recorded with a stopwatch. The mice in each group were scalded for 8s to complete the scald model.

[0087] After the scald model of the mice was completed, 0.1g of the burn and scald ointment was applied to the wound skin, once a day, and the wound healing rate was calculated. The results are shown in Table 1.

[0088] On the 14th day after the model was completed, the sulfuric acid paper marking method was used to mark the area with the mass instead of the area, and the average healing rate of the wound was calculated. The specific calculation formula is as follows:

[0089] Wound healing rate = (original scald area - unhealed area) / original scald area x 100%

[0090] Wound healing judgment standard: the wound scab falls off, new epidermis is generated, and fine villi appear.

[0091] Table 1

[0092] Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Skin healing rate (%) 86 35 27 19

[0093] From the data in Table 1, the skin healing rate of the burn and scald ointment of the present application in the scald experiment of mice was as high as 85% at 14 days, and the skin healing rate was higher than that of the burn and scald ointments of Comparative Examples 1-3.

[0094] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. For those skilled in the art, the present application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A burn cream, characterized in that, The raw material components are 10-20 parts of holly, 5-15 parts of gardenia, 1-5 parts of ox gall, 3-8 pieces of centipede, 1-3 parts of musk, 5-15 parts of greenbrier, 5-15 parts of buckwheat, 5-10 parts of coptis, 25-35 parts of dragon bone, 3-8 parts of amber, 5-15 parts of catechu, 3-8 parts of borneol, 5-15 parts of scrophularia, 5-15 parts of bletilla, 3-8 parts of beeswax.

2. The burn cream according to claim 1, wherein The raw material components are 15 parts of holly, 10 parts of gardenia, 3 parts of ox gall, 5 pieces of centipede, 2 parts of musk, 10 parts of greenbrier, 10 parts of buckwheat, 8 parts of coptis, 30 parts of dragon bone, 5 parts of amber, 10 parts of catechu, 5 parts of borneol, 10 parts of scrophularia, 10 parts of bletilla, 6 parts of beeswax.

3. The method of producing a burn cream according to claim 1 or 2, characterized in that, The method comprises the following steps: (1) mixing holly, greenbrier, coptis and scrophularia to obtain a mixture, adding water to the mixture, heating and extracting, and filtering to obtain a filtrate; (2) adding crushed ox gall, centipede, dragon bone, amber, bletilla, gardenia, musk, buckwheat, catechu, borneol and beeswax to the filtrate, heating and concentrating to obtain an extract, naturally cooling the extract, and obtaining the burn and scald ointment.

4. The method for preparing burn ointment according to claim 3, characterized in that, In step (1), the added water is 8-12 times the mass of the mixture, the heating temperature is 80-90°C, and the heating time is 4-5 hours.

5. The method for preparing burn ointment according to claim 3, characterized in that, In step (2), the particle size of the crushed material is 20 mesh, the heating temperature is 70-80°C, and the heating time is 10-15 hours.

6. Use of the burn and scald ointment of claim 1 or 2 in the preparation of a medicament for treating burns and scalds.