A dual-purpose medicinal and edible composition with improved blood glucose and blood lipid effects, and a preparation method and application thereof

Abstract

The application discloses a medicine-food composition with the effects of improving blood sugar and blood fat, which is prepared from wolfberry leaves, wolfberry fruits, hawthorn fruits, jujube, white lentil and lotus leaves. Under the guidance of the theory of traditional Chinese medicine, dialectical treatment is adopted, the pathogenesis and pathogenic symptoms of hyperglycemia and hyperlipidemia are combined, and prescription screening is carried out. The experimental results show that the medicine-food composition can improve the blood sugar of a diabetic model rat, can regulate the blood fat level of the body, and has the advantages of good curative effect, good taste, low toxic and side effect, and clinical drug safety.

Description

TECHNICAL FIELD

[0001] The present application relates to a traditional Chinese medicine composition, in particular to a dual-purpose medicine and food composition with the effects of reducing blood sugar and blood lipid, and a preparation method and application thereof. BACKGROUND

[0002] Diabetes is a group of metabolic diseases characterized by chronic high blood sugar levels, caused by insulin secretion and / or action defects. Diabetes patients often have high blood pressure, blood lipid disorders and other important risk factors. Today's diabetes treatment includes lifestyle intervention, smoking cessation, medical nutrition therapy, exercise therapy, drug therapy, and metabolic surgery treatment. Existing hypoglycemic drugs mainly include biguanides, glucoses, letins, sulfonylurea hypoglycemic drugs, letins, letins, and insulin, which have certain clinical treatment effects, but are prone to adverse reactions such as hypoglycemia, weight gain, and digestive tract reactions.

[0003] Hyperlipidemia refers to abnormal fat metabolism or transport, which causes the blood lipid content in the human body to exceed the normal range, manifested as high cholesterol and / or triglycerides or low high-density lipoprotein in the blood, which is called "dyslipidemia" in modern medicine. Hyperlipidemia is a common and frequently-occurring disease, and is also the culprit of cardiovascular and cerebrovascular diseases. The damage to the body is hidden, gradual, progressive, and systemic, and its direct damage is to accelerate the atherosclerosis of the whole body. Hyperlipidemia can be prevented and treated, and long-term lipid-lowering therapy can reduce the incidence and mortality of coronary heart disease, angina pectoris, myocardial infarction, stroke, and disability rate of diabetes.

[0004] Traditional Chinese medicine has unique effects in the prevention and treatment of chronic diseases such as diabetes or hyperlipidemia due to its advantages of multiple targets, bidirectional regulation, synergistic effect and reduced toxicity. At the same time, it has good clinical efficacy and small side effects. Therefore, under the guidance of traditional Chinese medicine theory, a dual-purpose medicine and food traditional Chinese medicine compound with the effects of reducing blood sugar and blood lipid and used for people's daily health care, safety and effectiveness has good market application prospect. SUMMARY

[0005] The purpose of the present application is to provide a dual-purpose medicine and food traditional Chinese medicine composition with the effects of reducing blood sugar and blood lipid, high safety, and no adverse reactions. Another purpose of the present application is to provide a preparation method and application of the dual-purpose medicine and food traditional Chinese medicine composition.

[0006] Technical solution: In order to achieve the above purpose, the technical solution adopted by the present application is:

[0007] A dual-purpose medicine and food traditional Chinese medicine composition with the effects of improving blood sugar and blood lipid is prepared from the following raw materials in parts by weight: 2-15 parts of wolfberry leaves, 1-10 parts of wolfberry fruits, 1-10 parts of hawthorn, 1-10 parts of white lentils, 1-8 parts of jujube, and 1-8 parts of lotus leaves.

[0008] As a preferred solution, the above-mentioned Gouqi-He Fenqing drink composition with the effect of improving blood sugar and blood lipid is made from the following raw materials in the weight ratio: Gouqi leaves 3-8 parts, Gouqi fruits 2-6 parts, hawthorn 2-6 parts, white lentil 2-6 parts, jujube 1-5 parts, lotus leaf 1-5 parts.

[0009] As a more preferred solution, the above-mentioned Gouqi-He Fenqing drink composition with the effect of improving blood sugar and blood lipid is made from the following raw materials in the weight ratio: Gouqi leaves 6 parts, Gouqi fruits 5 parts, hawthorn 5 parts, white lentil 5 parts, jujube 2 parts, lotus leaf 2 parts.

[0010] The preparation method of the dual-purpose medicinal and food composition with the effect of improving blood sugar and blood lipid comprises the following steps:

[0011] (1) Gouqi leaves, Gouqi fruits, hawthorn, white lentil, jujube, and lotus leaf are taken in weight ratio, mixed, extracted with water, filtered, and the filtrates are collected and combined to obtain an extract for standby use;

[0012] (2) The extract obtained in step (1) is concentrated to a specified concentration to obtain a concentrated solution;

[0013] (3) The concentrated solution obtained in step (2) is dried and pulverized to obtain the dual-purpose medicinal and food composition with the effect of improving blood sugar and blood lipid.

[0014] As a preferred solution, the preparation method of the dual-purpose medicinal and food composition with the effect of improving blood sugar and blood lipid described above, in step (1), the medicinal materials are extracted with 8-12 times the amount of water; the extraction method is decoction, reflux, or continuous reflux extraction, the extraction temperature is 95-100℃, and the extraction is performed 1-3 times, each time for 1-2 hours.

[0015] As a preferred solution, the preparation method of the dual-purpose medicinal and food composition with the effect of improving blood sugar and blood lipid described above, in step (2), the concentration method is reduced-pressure concentration, and the conditions are: vacuum degree ≤80 Pa, and concentration temperature ≤70℃.

[0016] As a preferred solution, the preparation method of the dual-purpose medicinal and food composition with the effect of improving blood sugar and blood lipid described above, in step (3), the drying method is spray drying, and the drying temperature is ≤70℃.

[0017] According to the physicochemical properties of the active ingredients in Gouqi leaves, Gouqi fruits, hawthorn, white lentil, jujube, and lotus leaf, and through a large number of experiments, the extraction and preparation processes are screened, the water decoction extraction process of Gouqi leaves and the like adopts the optimal process parameters, has the advantages of high extraction efficiency, no damage to the active ingredients in the plants, and low impurity component dissolution rate. The concentration and drying process can ensure that the active ingredients are not damaged.

[0018] A large number of experimental researches show that the medicinal and edible composition provided by the application can effectively improve blood sugar and blood lipid of diabetic rats, and the medicinal and edible composition provided by the application can effectively improve blood sugar level of model rats, and can be used for preparing functional food or medicine with the effects of improving blood sugar and blood lipid.

[0019] The medicinal and edible composition with the effect of reducing blood sugar provided by the application is used for preventing and improving hyperglycemia, and the medicinal and edible composition and a food-acceptable carrier are prepared into solid granular beverages, tablet candies, concentrated pastes and the like types of food.

[0020] When the medicinal and edible composition with the effect of reducing blood sugar provided by the application is prepared into a solid granular beverage, the composition is uniformly mixed with a diluent, and then a wet granulator or a dry granulator is used to prepare the solid granular beverage.

[0021] When the medicinal and edible composition with the effect of reducing blood sugar provided by the application is prepared into a tablet candy, the plant composition and lactose or corn starch are uniformly mixed to prepare granules, and then a tablet press is used to press the granules into the tablet candy.

[0022] When the medicinal and edible composition with the effect of reducing blood sugar provided by the application is prepared into a concentrated paste, the plant composition extract is concentrated to a suitable concentration, and then a paste filling machine is used to prepare the concentrated paste.

[0023] The medicinal and edible composition with the effect of reducing blood sugar provided by the application is prepared into a medicine in the form of an oral liquid, a capsule, a tablet, a granule, a dripping pill or a microcapsule by using a pharmaceutically acceptable carrier.

[0024] When the medicinal and edible composition provided by the application is prepared into a granule, the composition and a diluent, i.e., lactose or corn starch, are uniformly mixed, granulated, dried and prepared into the granule.

[0025] The medicinal and edible composition provided by the application has a good effect of reducing blood sugar, and can be used for preparing medicine for treating cardiovascular diseases and hyperglycemia or health care products.

[0026] The medicinal and edible composition provided by the application can be prepared into various dosage forms of medicine by using a pharmaceutically acceptable carrier, and is convenient for clinical use.

[0027] When the medicinal and edible composition provided by the application is prepared into other food or medicine dosage forms, the composition can be prepared by using a conventional method of food or medicine.

[0028] Beneficial effects: under the guidance of traditional Chinese medicine theory, the present application treats according to syndrome, combines the pathogenesis and pathogenic symptoms of hyperglycemia, and optimizes the prescription to obtain a medicine-food dual-purpose composition for improving blood glucose. In the prescription, the combination of wolfberry leaves and wolfberry seeds is the monarch, which nourishes liver and kidney, and supplements essence and blood; white kidney bean and jujube are spleen-qi-boosting and dampness-resolving, jujube is spleen-qi-boosting, hawthorn is stomach-qi-boosting and food-digesting, blood-activating and stasis-resolving, which can prevent wolfberry seeds and jujube from being greasy and hindering the spleen, and can also acid-sweetness Yin and nourish Yin and moisten dryness, and all of them are the minister drugs; safflower is used as the auxiliary, which can assist the spleen in ascending clear and descending turbid, dispersing stasis and resolving fat, and also can clear heat and drain dampness to remove internal heat. The combination of various drugs can supplement liver and kidney, restore the operation of the spleen, resolve stasis, remove internal heat, and distribute water and fluid, so that various symptoms can be solved, and the whole composition is scientifically reasonable. The experimental results show that the medicine-food dual-purpose composition provided by the present application has good auxiliary blood glucose lowering effect, can prevent and treat hyperlipidemia, and can prevent and treat cardiovascular diseases, and the medicine-food dual-purpose composition is safe in clinical use because all the drugs are homologous raw materials, have good curative effect, and low toxicity and side effects.

[0029] The medicine-food dual-purpose composition provided by the present application has the following advantages compared with the prior art:

[0030] The present application scientifically and reasonably selects the ratio of each component through a large number of experiments, and the whole preparation process has high automation degree and high preparation efficiency, and can well retain the effective components in the raw materials. Especially importantly, all the components of the medicine-food dual-purpose composition are medicine-food dual-purpose species, which are safe and suitable for long-term use, and can prevent and improve blood glucose disorder and hyperlipidemia. DETAILED DESCRIPTION

[0031] The present application will be further illustrated by specific examples, and it should be understood that these examples are only used to illustrate the present application and not used to limit the scope of the present application, and various equivalent modifications of the present application made by those skilled in the art after reading the present application all fall within the scope defined by the claims attached hereto.

[0032] Example 1

[0033] 1. A medicine-food dual-purpose composition for improving blood glucose and blood lipid, which is prepared from the following raw materials in parts by weight:

[0034] 6 parts of wolfberry leaves, 5 parts of wolfberry seeds, 5 parts of hawthorn, 5 parts of white kidney bean, 2 parts of jujube, and 2 parts of safflower.

[0035] 2. A preparation method of a medicine-food dual-purpose composition for improving blood glucose and blood lipid, comprising the following steps:

[0036] (1) 6 parts of wolfberry leaves, 5 parts of wolfberry seeds, 5 parts of hawthorn, 5 parts of white kidney bean, 2 parts of jujube, and 2 parts of safflower are mixed, 12 times the weight of water of the medicinal materials is added for reflux extraction for 2 times, each time for 1.5 hours, filtration is performed, and the 2 times of filtrates are collected and combined to obtain water decoction for standby;

[0037] (2) taking the water decoction obtained in step (1), under the conditions of vacuum degree ≤80 Pa and concentration temperature ≤70 ℃, the water decoction is concentrated under reduced pressure to obtain a concentrated solution;

[0038] (3) taking the concentrated solution obtained in step (2), the concentrated solution is dried by hot air drying method at a drying temperature of ≤80 ℃, and then crushed to obtain the composition having the effect of improving blood glucose and blood lipid.

[0039] Example 2

[0040] 1. A medicinal and edible composition having the effect of improving blood glucose and blood lipid, which is prepared from the following raw materials in parts by weight:

[0041] 5 parts of wolfberry leaves, 6 parts of wolfberry fruits, 6 parts of hawthorn, 5 parts of white lentils, 3 parts of jujube, and 3 parts of lotus leaves.

[0042] 2. A preparation method of a medicinal and edible wolfberry and lotus leaf composition having the effect of improving blood glucose and blood lipid, comprising the following steps:

[0043] (1) taking 5 parts of wolfberry leaves, 6 parts of wolfberry fruits, 6 parts of hawthorn, 5 parts of white lentils, 3 parts of jujube, and 3 parts of lotus leaves, mixing, adding water in an amount of 10 times the weight of the medicinal materials, reflux extracting 3 times for 1 hour each time, filtering, collecting and combining the 3 filtrates to obtain wolfberry and lotus leaf composition water decoction for use;

[0044] (2) taking the water decoction obtained in step (1), under the conditions of vacuum degree ≤80 Pa and concentration temperature ≤70 ℃, the water decoction is concentrated under reduced pressure to obtain a concentrated solution;

[0045] (3) taking the concentrated solution obtained in step (2), the concentrated solution is dried by vacuum drying method at a drying temperature of ≤70 ℃, to obtain the composition having the effect of improving blood glucose and blood lipid.

[0046] Example 3

[0047] 1. A medicinal and edible composition having the effect of improving blood glucose and blood lipid, which is prepared from the following raw materials in parts by weight: 9 parts of wolfberry leaves, 7 parts of wolfberry fruits, 2 parts of hawthorn, 7 parts of white lentils, 1 part of jujube, and 6 parts of lotus leaves.

[0048] 2. A preparation method of a medicinal and edible composition having the effect of improving blood glucose and blood lipid, comprising the following steps:

[0049] (1) taking 9 parts of wolfberry leaves, 7 parts of wolfberry fruits, 2 parts of hawthorn, 7 parts of white lentils, 1 part of jujube, and 6 parts of lotus leaves, mixing, adding water in an amount of 8 times the weight of the medicinal materials, reflux extracting 3 times for 1.5 hours each time, filtering, collecting and combining the 3 filtrates to obtain wolfberry and lotus leaf composition water decoction for use;

[0050] (2) Take the water decoction obtained in step (1), and concentrate under reduced pressure at a vacuum degree of ≤80 Pa and a concentration temperature of ≤70°C to obtain a concentrated solution;

[0051] (3) Take the concentrated solution obtained in step (2), and dry by spray drying at a drying temperature of ≤70°C to obtain the medicinal and edible composition with the effects of improving blood sugar and blood lipid.

[0052] Example 4

[0053] A preparation method of a medicinal and edible solid granular beverage with the effects of improving blood sugar and blood lipid, comprising the following steps:

[0054] (1) Take the composition obtained in Example 1, and add soluble starch and essence and spices, and mix uniformly, and granulate by a dry granulator;

[0055] (2) Take the granules obtained in step (1), and pack in aluminum-plastic composite bags by a granule packing machine.

[0056] Example 5

[0057] A preparation method of a medicinal and edible tablet candy with the effects of improving blood sugar and blood lipid, comprising the following steps:

[0058] (1) Take the composition obtained in Example 2, and add lactose, compressible starch and essence and spices, and mix uniformly; granulate by a wet granulator, and dry at a temperature of ≤60°C, and sieve;

[0059] (2) Take the granules obtained in step (1), and place in a mixer, and add a tabletting lubricant, and mix for 15 minutes, and press into tablet candies by a tablet press.

[0060] Example 6

[0061] A preparation method of a medicinal and edible concentrated paste with the effects of improving blood sugar and blood lipid, comprising the following steps:

[0062] (1) Take the composition obtained in Example 3, and dissolve in an appropriate amount of water, and then add honey, and heat and mix uniformly to obtain a prepared concentrated paste;

[0063] (2) Take the prepared concentrated paste solution obtained in step (1), and fill in glass bottles by a paste filling machine, with a capacity of 250 g or 500 g per bottle; or fill in aluminum-plastic strip bags, with a capacity of 10 g or 20 g per bag.

[0064] Example 7 Experimental study on the effects of improving blood sugar and blood lipid

[0065] I. Experimental materials and drugs

[0066] 1. Experimental materials

[0067] Glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol kits (Nanjing Jiancheng Biological Engineering Institute);

[0068] 2. Experimental instruments

[0069] Enspire multifunctional microplate reader (PerkinElmer, USA); San'ao stable blood glucose meter (batch number 2K01B200724, San'ao Biosensor Company)

[0070] 3. Test drugs and treatment methods

[0071] The food-medicinal composition prepared in Example 1, Example 2 and Example 3 is added to pure water to prepare a solution with the required concentration. Streptozotocin (item number: WXBD7077V, Sigma, USA), sodium citrate buffer (0.1 mmol / L pH 4.0, batch number 20230202, Solabio, Beijing), metformin hydrochloride (batch number: ACH0111)

[0072] 4. Test animals

[0073] Male SD rats, SPF level, body weight 180-220 g, purchased from Shanghai Slek Experimental Animal Co., Ltd., qualified certificate number SCXK (Shanghai) 2022-0004, ethical number 202210A067. The animals were raised in the Experimental Animal Center of Nanjing University of Chinese Medicine, with a feeding temperature of 20-25°C and an environmental humidity of 45%±10%. The animals were adaptively fed for one week before the experiment, with free access to water and food, and a 12-hour day-night rhythm was maintained.

[0074] II. Experimental methods

[0075] 1. Animal model replication, grouping, drug administration and sample collection

[0076] After the rats were adaptively fed for one week, they were randomly divided into a normal group, a model group, an Example 1 administration group, an Example 2 administration group and an Example 3 administration group, with 8 rats in each group. The dosage was calculated based on the recommended human oral dose (10 g / d), and the dosage was equivalent to 5 times the recommended human dose. The rats had free access to water; the normal group was given maintenance feed, and the model group and the administration groups were given high-fat feed for four weeks. After 12 hours of fasting, the rats were intraperitoneally injected with streptozotocin at a dose of 30 mg·kg -1 Streptozotocin was administered for three consecutive days, and rats with fasting blood glucose values FIB≧16 mmol / L were selected as model rats for subsequent experiments. After the model was successfully established, the normal group was given maintenance feed, and the model group and the administration groups were given high-fat feed and free access to water. The rats were administered for 30 consecutive days, with 1 mL of the drug solution administered per 100 g of body weight. The blank group was given an equal volume of normal saline. The blood glucose and blood lipid levels were measured, and the blood glucose changes are shown in Table 1, and the blood lipid levels are shown in Table 2.

[0077] All experimental data were statistically processed by SPSS11.5 statistical processing software, the results were expressed as (mean ± SD), and t test was used for comparison between groups.

[0078] III. Experimental results

[0079] 1. Changes of blood glucose in rats

[0080] Table 1 Changes of blood glucose in rats treated by the medicinal and edible composition (mmoL)

[0081] Group Blood glucose level after modeling / drug administration Blood glucose level after 30 days of drug administration Blank group 4.36±0.24 4.61±0.33 Model group 21.13±6.35*** 20.91±6.82*** Positive drug group 19.91±5.65 9.39 ± 1.90 # ]] Example 1 group 19.76±2.01 11.89 ± 1.80 # ]] Example 2 group 19.53±3.63 12.91 ± 2.15 # ]] Example 3 group 19.08±3.55 13.15 ± 1.54 # ]]

[0082] (Note: ***P <0.01, comparison between the model group and the blank group; # P <0.05, comparison between the drug administration group and the model group)

[0083] 2. Changes of blood lipids in rats

[0084] Table 2 Changes of blood lipids in rats treated by the medicinal and edible Qihuo Fensheng drink composition (mmoL)

[0085]

[0086] (Note: ***P <0.01, comparison between the model group and the blank group; # P <0.05, comparison between the drug administration group and the model group; ### P <0.01, comparison between the drug administration group and the model group)

[0087] The above experimental results show that the medicinal and edible composition provided by the present application has good hypoglycemic effect in the rat diabetes model, and also has good improvement effect on blood lipids. Compared with the existing drugs, the composition uses natural traditional medicinal and edible raw materials with multiple health care effects, and is safer and has no adverse reactions.

[0088] The above description is only the preferred embodiments of the present application, and it should be noted that for those skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, and these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A health food composition having an effect of improving blood sugar and blood lipid, characterized by comprising, It is made from the following raw materials by weight fraction: wolfberry leaves 6 parts, wolfberry 5 parts, hawthorn 5 parts, white beans 5 parts, jujube 2 parts, lotus leaf 2 parts.

2. The method of preparing the medicinal and edible composition according to claim 1, characterized in that, It comprises the following steps: (1) wolfberry leaves, wolfberry, hawthorn, white beans, jujube, lotus leaf are taken by weight fraction respectively, mixed, extracted with water, filtered, collected and combined the filtrate to obtain the extract for standby; (2) the extract obtained in step (1) is taken, concentrated to obtain a concentrated solution; (3) the concentrated solution obtained in step (2) is taken, dried, and pulverized to obtain a medicinal and edible composition with the effect of improving blood sugar and blood lipid.

3. The process for preparing the health food composition having effect of improving blood sugar and blood lipid according to claim 2, wherein the process is characterized by, Step (1) is extracted with 8-12 times the weight of water; the extraction method is decoction, reflux or continuous reflux extraction method, the extraction temperature is 95-100 ℃, the extraction times is 1-3 times, and each time is 1-2 hours; step (2) the concentration method is reduced pressure concentration, and the condition is: vacuum degree ≤80Pa, concentration temperature ≤70℃.

4. The process for preparing the health food composition having effect of improving blood sugar and blood lipid according to claim 3, wherein the process is characterized by, Step (3) the drying method is spray drying, and the drying temperature is ≤70℃.

5. The medicinal and edible composition with the effect of improving blood sugar and blood lipid of claim 1 in the preparation of a medicine for assisting in improving the effect of blood sugar and blood lipid.

6. Use according to claim 5, characterized in that, The medicinal and edible composition and a pharmaceutically acceptable carrier are prepared into oral liquid, capsule, tablet, granule, drop pill or microcapsule type medicine.

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