A dry granulation and filling apparatus

The combination of dry granulation and filling equipment enables continuous production of pharmaceutical powder, solving the problems of batch-to-batch differences and inaccurate dosage control in batch production, improving the flowability of pharmaceutical powder and the accuracy of dosage control, and increasing production efficiency.

CN117547463BActive Publication Date: 2026-01-30CHINA PHARM UNIV
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Patent Information

Application Number
CN202311504606.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-11-13
Publication Date
2026-01-30
Estimated Expiration
2043-11-13

AI Technical Summary

Technical Problem

In the existing technology, the batch-to-batch production of dry powder inhalers leads to batch-to-batch variability, which affects efficacy. Furthermore, the poor powder flowability results in inaccurate dosage control, making continuous production impossible.

Method used

The combination of a feeding device, a scraper screen device, a vibrating spheroidizing device, a filter screen device, and a metering and filling device enables continuous production of feeding, granulation, spheroidizing, screening, and quantitative filling. The rotary scraper, vibrating spheroidizing, and screening devices improve the flowability and metering accuracy of the powder.

Benefits of technology

It enables continuous production of drug powder, avoids batch variations, improves drug powder flowability and dosage control accuracy, and enhances production efficiency and drug delivery accuracy.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the technical field of dry powder inhaler granulation equipment, specifically to a dry granulation and filling device, comprising a frame, a feeding device, a scraper screen device, a vibrating spheroidizing device, a filtering screen device, and a metering and filling device. The feeding device, scraper screen device, vibrating spheroidizing device, filtering screen device, and metering and filling device are supported by the frame and arranged sequentially along the flow direction of the granular material. The feeding device is fixedly mounted on one side of the frame. The scraper screen device is located on one side of the feeding device and fixed to the frame. One end of the vibrating spheroidizing device is located below the discharge port of the scraper screen device, and the other end is located above the filtering screen device, and both are fixed to the frame. The filtering screen device is located below the discharge port of the vibrating spheroidizing device and fixed to the frame. The metering and filling device is located below the discharge port of the filtering screen device and is fixedly connected to the frame. This invention achieves continuous production by coordinating the various devices, thus improving production efficiency.
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Description

Technical Field

[0001] This invention relates to the field of dry powder inhaler granulation equipment technology, specifically to a dry granulation and filling equipment. Background Technology

[0002] Dry powder inhalers (DPIs) are a common dosage form that delivers medication into the respiratory tract through inhalation to achieve therapeutic purposes. The active ingredient in DPIs is typically in the form of particles ranging from 1 to 5 μm. When the solid particle size is in the micrometer range, the powder's flowability decreases, usually requiring the addition of excipients such as lactose to improve flowability. However, this limits the possibility of delivering high doses of medication.

[0003] In existing technologies, batch production is typically used to mitigate the effects of high-dose drug delivery. However, this results in batch-to-batch variations, affecting efficacy. Furthermore, the poor flowability of powdered substances leads to insufficient precision in metering, resulting in inaccurate dosage control and impacting patient outcomes. To address these issues, those skilled in the art have made numerous attempts. For example, Chinese patent application 2021105824277 discloses a dry granulation system, including a granulator, elevator, screening machine, granule silo, bag filter, and powder silo. The granulator comprises a granulation roller, inlet end, outlet end, and screw conveyor. These components work together to integrate granulation, screening, and collection. While this method solves the problem of poor flowability, it still requires additional metering and filling processes, hindering continuous production and resulting in low efficiency. Summary of the Invention

[0004] To address the aforementioned problems, this invention provides a dry granulation and filling equipment. By combining a feeding device, a scraper screen device, a vibrating spheroidizing device, a filter screen device, and a metering filling device, it achieves continuous production of feeding, granulation, spheroidizing, screening, and quantitative filling, thereby greatly improving production efficiency.

[0005] To achieve the above objectives, the present invention provides a dry granulation and filling equipment, comprising a frame, a feeding device, a scraper screen device, a vibrating spheroidizing device, a filtering screen device, and a metering and filling device. The feeding device, scraper screen device, vibrating spheroidizing device, filtering screen device, and metering and filling device are all supported by the frame and arranged sequentially along the flow direction of the granular material. The feeding device is fixedly mounted on one side of the frame. The scraper screen device is located on one side of the feeding device and fixed to the frame. One end of the vibrating spheroidizing device is located below the discharge port of the scraper screen device, and the other end is located above the filtering screen device, and both are fixed to the frame. The filtering screen device is located below the discharge port of the vibrating spheroidizing device and fixed to the frame. The metering and filling device is located below the discharge port of the filtering screen device and is fixedly connected to the frame.

[0006] During operation, powdered material is conveyed from the feeding device to the scraper screen device, where it is initially granulated and then fed to the vibrating spheroidizing device. The granules gradually transform into spherical shapes as the vibrating spheroidizing device moves, and are then conveyed to the filtering screen device. After the filtering screen separates the granules from the residual powder, it conveys the granules to the metering and filling device while simultaneously collecting the remaining powder. Finally, the metering and filling device quantitatively fills the granules, achieving continuous production from feeding, granulation, spheroidizing, screening, to quantitative filling.

[0007] Furthermore, the metering and filling device includes a mounting base, a fourth support, and a metering structure; the mounting base is fixed inside the frame; the fourth support is fixed on the mounting base; and the metering structure is fixed on the fourth support.

[0008] Furthermore, the metering structure includes a drive cylinder, a material cylinder, and a metering tube; both the drive cylinder and the material cylinder are fixed on the fourth support; a baffle tube is provided below the material cylinder, and a discharge tube is provided on one side of the baffle tube; the upper part of the metering tube is located inside the baffle tube and is slidably connected to the baffle tube, while the lower part is fixed on the drive cylinder; a metering groove is provided inside the metering tube; a filling hole is opened at the bottom of the metering groove; the metering tube is driven to slide up and down by the drive cylinder, so that the position of the filling hole corresponds to the upper inlet of the discharge tube, thereby realizing the quantitative filling of granular materials.

[0009] By combining metering tubes and cylinders, and relying on the self-weight and good flowability of the powder spheroids, quantitative filling is achieved, improving the accuracy of metering control; and the dosage control of the powder spheres is realized, ensuring the accuracy of each dose through volume-based quantitative filling.

[0010] Furthermore, the scraper screen device includes a second support, a second drive motor, and a granulation structure; the second support is fixed on the frame; the second drive motor is fixed on the upper end of the second support; the granulation structure is located below the second drive motor and is fixed on the second support.

[0011] Furthermore, the granulation structure includes a clamping ring, a screen cylinder, and a scraper shaft; the clamping ring has connecting plates at both ends, which are fixedly connected to the second support through the connecting plates; the screen cylinder is located inside the clamping ring and is fixed below the second drive motor through the clamping ring; a first screen is provided inside the screen cylinder; the upper end of the scraper shaft is connected to the second drive motor, and a rotating scraper is provided at the lower end; the rotating scraper is placed inside the screen cylinder and there is a gap between it and the first screen.

[0012] The rotating scraper evenly scrapes the powder through the sieve, pre-forming it into small particles. This effectively prevents the powder from agglomerating during feeding, thus affecting its flowability, and also helps to form a more uniform particle distribution.

[0013] Furthermore, the feeding device includes a first drive motor and a first bracket fixedly mounted on the frame; the first drive motor is fixed to the upper end of the first bracket; a conveying pipe is provided on the right side of the first drive motor; a feed hopper is provided on the conveying pipe, and a conveying screw is provided inside; the conveying screw is fixedly connected to the output shaft of the first drive motor.

[0014] The conveying screw can stably transport ultrafine medicine powder to the scraper screen device, reducing the clumping of medicine powder during the conveying process.

[0015] Furthermore, the vibrating spheroidizing device includes a support base, a linear vibrator, and a discharge plate; the support base is fixedly mounted on the frame; the linear vibrator is fixedly mounted on the support base; the discharge plate has first baffles on both sides and is fixed to the linear vibrator; the left end of the discharge plate is higher than the right end, and the left end is located below the screen cylinder, while the right end is located above the filter screen device.

[0016] By controlling the movement of the powder on the discharge plate through a vibrating spheroidizing device, the powder is spheroidized and forms small, free-flowing spheres during vibration, thereby improving the powder's flowability and facilitating subsequent filling.

[0017] Furthermore, the filtering screen device includes a third support fixed on the frame, a third drive motor, a screening mechanism, and a transmission mechanism; the third support is provided with a slide rail; the third drive motor is fixed on one side of the third support; the screening mechanism is located above the third support and is connected to the third support through the slide rail; one end of the transmission mechanism is connected to the third drive motor, and the other end is connected to the screening mechanism.

[0018] Furthermore, the screening mechanism includes a support frame, a screen plate, and a powder discharge trough; the transmission mechanism includes a rotating wheel, an eccentric shaft, and a rocker arm; the support frame is slidably connected to the slide rail; the powder discharge trough is fixed on the support frame; second baffles are provided on both sides of the screen plate and fixed on the powder discharge trough; the ends of the screen plate and the powder discharge trough are respectively provided with a material drop pipe and a discharge pipe; the rotating wheel is fixed on the output shaft of the third drive motor; one end of the eccentric shaft is fixedly connected to the rotating wheel, and the other end is rotatably connected to the rocker arm; the rocker arm is rotatably connected to the support frame; the drive motor drives the rocker arm to swing through the rotating wheel and the eccentric shaft, thereby driving the support frame to swing, thereby driving the screen plate and the powder discharge trough to swing, so as to realize the screening and collection of granular materials and residual powdery materials.

[0019] By using a filtration sieve device to separate particulate materials and residual powder materials, fine powder can be filtered out, which can effectively achieve controllable drug granulation, reduce dust generation, and improve the operating environment.

[0020] Furthermore, the mounting base includes a mounting base plate, a mounting top plate, and rubber columns. The mounting base plate is fixedly connected to the frame; the rubber columns are fixed to the mounting base plate; the mounting top plate is fixed to the rubber columns and fixedly connected to the frame; the mounting top plate is equipped with a pneumatic hammer to make the material filling in the barrel more compact.

[0021] The pneumatic hammer ensures that the material inside the cylinder is filled more densely, guaranteeing a stable filling volume each time.

[0022] The beneficial effects of the technical solution described in this invention are as follows:

[0023] 1. The raw medicinal powder is conveyed to the sieve cylinder of the scraper sieve device through the feeding device. The rotating scraper in the sieve cylinder interacts with the first sieve to evenly scrape the powder through the first sieve, so that the powder is evenly dispersed and initially granulated into small particles. The granulated powder falls onto the discharge plate of the vibrating spheroidizing device. The powder particles roll along the discharge plate and are spheroidized into small, free-flowing spherical particles. The spheroidized particles roll down the discharge plate onto the sieve plate of the filtering sieve device, where the fine powder is filtered out, thus obtaining sieved powder spheres. The powder spheres roll into the material cylinder for filling. The spherical granules in the material cylinder are connected to the metering pipe and the baffle pipe. After the metering pipe is full of granules, a fixed amount of granules is output from the discharge pipe for filling. This realizes continuous production of powder granulation and quantitative filling, and avoids batch-to-batch differences in batch production. Granulation improves the flowability of the powder, and quantitative filling improves the accuracy of dosage control, greatly improving production efficiency.

[0024] 2. During the process of the metering tube moving up and down within the baffle tube by the drive rod, when the metering tube moves upward, it extends above the bottom of the cylinder and fills the metering groove with granules. At the same time, the filling hole aligns with the upper inlet of the outlet tube, thus filling the granules in the metering tube. After filling, the metering tube moves downward to the initial position for the next round of quantitative filling, and the cycle continues. Continuous quantitative filling provides accurate measurement control, avoids the problem of affecting patients due to improper dosage control, and improves filling efficiency.

[0025] 3. The rotating scraper in the sieve cylinder interacts with the first sieve to evenly scrape the powder through the first sieve, so that the powder is evenly dispersed and initially granulated into small particles. The powder particles fall onto the discharge plate in the vibrating spheroidizing device, and the powder particles roll along the discharge plate to form small spherical particles with good flowability. In this way, the powder is made into spherical granules, which improves the flowability of the medicine and provides a guarantee for subsequent quantitative filling.

[0026] 4. The screen plate is driven by the fourth drive motor to shake, screen the medicine particles and residual powder, and collect the screened powder. This avoids the problem of medicine particles being mixed with powder during filling, which affects the control accuracy of the medicine dosage, and at the same time reduces the generation of dust. Attached Figure Description

[0027] To make the content of this invention easier to understand, the invention will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0028] Figure 1 A three-dimensional structural diagram of a novel dry granulation and filling equipment provided by the present invention. Figure 1 ;

[0029] Figure 2 A three-dimensional structural diagram of a novel dry granulation and filling equipment provided by the present invention. Figure 2 ;

[0030] Figure 3 This is a front view cross-sectional structural diagram of a novel dry granulation and filling equipment provided by the present invention;

[0031] Figure 4 This is a schematic diagram of the left-side cross-sectional structure of a novel dry granulation and filling equipment provided by the present invention;

[0032] Figure 5 A three-dimensional structural diagram of a portion of a novel dry granulation and filling equipment provided by this invention. Figure 1 ;

[0033] Figure 6 A three-dimensional structural diagram of a portion of a novel dry granulation and filling equipment provided by this invention. Figure 2 ;

[0034] Figure 7 A cross-sectional structural diagram of the metering pipe section in a novel dry granulation and filling equipment provided by the present invention;

[0035] Figure 8 This is a schematic cross-sectional view of the metering tube in the present invention with the filling hole and the discharge hole connected.

[0036] Figure 9 This is a three-dimensional structural diagram of the filter screen device and the metering and filling device in this invention.

[0037] Wherein: 1-Frame; 2-Feeding device; 21-Conveying pipe; 22-Conveying screw; 23-First support; 24-Feeding hopper; 25-First drive motor; 26-Conveying blade; 3-Scraper screen device; 31-Screw cylinder; 32-First screen; 33-Rotating scraper; 34-Second support; 35-Clamping ring; 351-Connecting plate; 352-Elongated hole; 36-Second drive motor; 37-Scraper shaft; 4-Vibrating balling device; 41-Discharge plate; 42-Supporting base plate; 43-Rubber support leg; 44-Linear vibrator; 45-First baffle; 5-Filtering screen device; 51-Screen plate; 52-Third support; 53-Slide rail; 54-Support frame; 55-Third drive motor; 56-Rotator; 57-Eccentric shaft; 58-Rock arm; 59-Powder outlet trough; 510-Discharge pipe; 511-Second baffle; 512-Discharge pipe; 6-Metering and filling device; 61-Material cylinder; 62-Baffle pipe; 63-Metering pipe; 631-Metering groove; 632-Filling hole; 64-Discharge pipe; 65-Mounting base; 651-Mounting base plate; 652-Mounting top plate; 653-Rubber column; 67-Pneumatic hammer; 68-Fourth support; 69-Drive cylinder. Detailed Implementation

[0038] The technical solution of the present invention will be further described below with reference to the accompanying drawings, but it is not limited thereto. Any modifications or equivalent substitutions to the technical solution of the present invention that do not depart from the spirit and scope of the technical solution of the present invention should be covered within the protection scope of the present invention.

[0039] like Figure 1 and Figure 2 As shown, this embodiment provides a dry granulation and filling equipment, including a frame 1. The frame 1 is sequentially equipped with a feeding device 2, a scraper screen device 3, a vibrating spheroidizing device 4, a filter screen device 5, and a metering and filling device 6. The feeding device 2 is fixed on the left side of the frame 1, the scraper screen device 3 is fixed on the frame 1 and located on the right side of the feeding device 2, the vibrating spheroidizing device 4 is fixed on the frame 1, with its left end located below the discharge port of the feeding device 2 and its right end located above the filter screen device 5. The filter screen device 5 is fixed on the frame 1 and located on one side of the vibrating spheroidizing device 4. The metering and filling device 6 is fixed inside the frame 1 and located below the discharge port of the filter screen device 5.

[0040] like Figure 3As shown, the feeding device 2 includes a first support 23, which is fixed to the surface of the frame 1 by bolts. The first support 23 includes two symmetrically arranged vertical plates, and a first drive motor 25 is provided between the two vertical plates. The first drive motor 25 is fixed to the top of the first support 23 by bolts. A conveying pipe 21 is provided on the right side of the first drive motor 25. The left end of the conveying pipe 21 is fixed to the first drive motor 25, and the right end is provided with a downward-sloping discharge port. A feed hopper 24 is provided on the conveying pipe 21, and a conveying screw 22 is provided inside the conveying pipe 21. The left end of the conveying screw 22 is fixedly connected to the output shaft of the first drive motor 25, and the right end extends to the end of the conveying pipe 21. Conveying blades are provided on the conveying screw 22.

[0041] In use, the powder is injected from the feed hopper 24 into the conveying pipe 21. After the first drive motor 25 starts, it drives the conveying screw 22 to rotate, thereby driving the conveying blades to rotate and pushing the injected powder to the discharge port at the right end of the conveying pipe 21, so that the powder is injected into the scraper screen device 3 from the discharge port.

[0042] like Figure 5 As shown, the scraper screen device 3 includes a second support 34, a second drive motor 36, and a granulation structure. The second support 34 is fixed to the surface of the frame 1, the second drive motor 36 is fixed to the upper end of the second support 34, and the granulation structure is located below the second drive motor 36. The granulation structure includes a scraper shaft 37, a clamping ring 35, and a screen cylinder 31. Each end of the clamping ring 35 is provided with a connecting plate, and the connecting plate has a connecting hole. The clamping ring 35 is fixed to the second support 34 by bolts and connecting holes. The screen cylinder 31 is fixed below the second drive motor 36 by the clamping ring 35 and is located below the discharge port of the conveying pipe 21. The screen cylinder 31 is provided with a first screen 32 with screen holes, and the first screen 32 is fixed. At the bottom of the sieve cylinder 31; the upper end of the scraper shaft 37 is connected to the output shaft of the second drive motor 36, and the lower end is provided with a rotating scraper 33. The rotating scraper 33 is fixed on the outer wall of the scraper shaft 37, placed inside the sieve cylinder 31, and there is a gap between it and the first screen 32. Specifically, by adjusting the distance of the bolt in the connecting hole, the position of the clamping ring 35 on the second bracket 34 can be adjusted, thereby adjusting the height of the sieve cylinder 31 to adjust the distance between the rotating scraper 33 and the first screen 32. By adjusting the running speed of the second drive motor 36, the rotation speed of the rotating scraper 33 can be adjusted. Combining the two adjustment methods, the fine control of the size and flowability of the powder particles can be achieved.

[0043] In use, the second drive motor 36 drives the scraper shaft 37 to rotate, which in turn drives the rotating scraper 33 to rotate, so that the rotating scraper 33 scrapes the medicine powder evenly across the first screen 32 to generate small medicine powder particles; through the relative movement of the rotating scraper 33 and the first screen 32, the medicine powder is evenly dispersed and initially granulated, which improves the flowability of the medicine powder.

[0044] like Figure 2 and Figure 3 As shown, the vibratory spheroidizing device 4 includes a support base, a linear vibrator 44, and a discharge plate 41. The support base includes four rubber legs 43 and a support base plate 42. The four support legs are located at the four corners of the support base plate 42 and are fixed to the surface of the frame 1. The support base plate 42 is placed on the rubber legs 43 and is fixedly connected to the four rubber legs 43 by bolts. The linear vibrator 44 is fixed on the support base plate 42, and the discharge plate 41 is fixed to the linear vibrator 44 by bolts. The discharge plate 41 has first baffles 45 on both sides. The left end of the discharge plate 41 is located below the screen cylinder 31, and the right end is located above the filter screen device 5. The discharge plate 41 is inclined, with the left end slightly higher than the right end. The inclination angle of the discharge plate 41 is adjusted according to the state of the powder particles to control the movement state of the powder on the discharge plate 41 and better achieve the spheroidization of the powder particles.

[0045] like Figure 4 , Figure 6 and Figure 9 As shown, the filter screen device 5 includes a third support 52, a third drive motor 55, a screening mechanism, and a transmission mechanism. The third support 52 is fixed to the surface of the frame 1, and the third drive motor 55 is fixedly installed on the side of the third support 52. A slide rail 53 is provided in the middle of the third support 52, and the slide rail 53 is fixedly connected to both sides of the third support 52 by bolts. The screening mechanism includes a support frame 54, a powder outlet trough 59, and a screen plate 51. The support frame 54 is slidably connected to the slide rail 53, and the powder outlet trough 59 is fixedly installed on the support frame 54. The screen plate 51 is fixedly installed above the powder outlet trough 59. Both the screen plate 51 and the powder outlet trough 59 are fixedly on the support frame 54 at an incline. The end of the screen plate 51 is provided with a discharge pipe 512, and the end of the powder outlet trough 59 is provided with a discharge pipe 510. The transmission mechanism includes a rotating wheel 56, an eccentric shaft 57, and a rocker arm 58. The rotating wheel 56 is fixedly connected to the output shaft of the third drive motor 55. One end of the eccentric shaft 57 is fixed at the eccentric position of the rotating wheel 56, and the other end is rotatably connected to the rocker arm 58. The rocker arm 58 is rotatably connected to the support frame 54 through a pin.

[0046] In use, the third drive motor 55 starts, driving the eccentric shaft 57 to rotate eccentrically via the rotating wheel 56. The eccentric shaft 57 drives the rocker arm 58 to swing, thereby driving the support frame 54 to perform reciprocating linear motion. This causes the support frame 54 to slide back and forth on the slide rail 53, and drives the powder discharge trough 59 and the screen plate 51 to perform linear reciprocating motion, thereby screening out spherical medicine particles and residual medicine powder. The medicine particles and medicine powder move along the screen plate 51 and the powder discharge trough 59 to the discharge pipe 512 and the discharge pipe 510, respectively. At this time, the medicine particles are transported to the metering and filling device 6 through the discharge pipe 512, while the medicine powder is collected separately and reused through the discharge pipe 510.

[0047] like Figure 4 , Figure 7 and Figure 8 As shown, the metering and filling device 6 includes a fourth support 68, a mounting base 65, and a metering structure. The mounting base 65 includes a mounting base plate 651, rubber columns 653, and a mounting top plate 652. The mounting base plate 651 is fixedly mounted on the side wall of the frame 1, the rubber columns 653 are fixedly mounted on the mounting base plate 651, and the mounting top plate 652 is fixed on the rubber columns 653. The fourth support 68 is fixed on the mounting top plate 652 and is in a two-stage stepped configuration. The metering structure includes a drive cylinder 69, a material cylinder 61, and a metering tube 63. The drive cylinder 69 is fixed on the first step of the fourth support 68, and the material cylinder 61 is fixed on the second step of the fourth support 68. A baffle tube 62 is fixedly connected to the bottom of the material cylinder 61. The baffle tube 62 is integrally formed with the material cylinder 61. The internal cavity of the baffle tube 62 is connected to the internal cavity of the material cylinder 61. The bottom end of the material cylinder 61 is a tapered structure that tapers inward. The lowest point of the bottom of the material cylinder 61 is flush with the top end face of the fourth support 68. A discharge port is opened on the side of the baffle tube 62. A discharge tube 64 is fixedly connected to the position of the discharge port on the side wall of the baffle tube 62. The upper part of the metering tube 63 is placed inside the baffle tube 62 and is slidably connected to the baffle tube 62. The lower end is fixedly connected to the end of the telescopic rod of the drive cylinder 69. A metering groove 631 is opened inside the metering tube 63. A filling hole 632 is opened on the bottom side of the metering groove 631.

[0048] In use, the metering tube 63 is in its initial position, with its top end flush with the bottom surface of the cylinder 61. When the granules fall into the cylinder 61 from the discharge pipe 512, they roll along the conical surface to the bottom of the cylinder 61 and fall into the metering groove 631. After the metering groove 631 is full, the drive cylinder 69 drives the metering tube 63 to move upward, making the inlet of the metering groove 631 higher than the bottom surface of the cylinder 61, and moving the filling hole 632 to the granule inlet of the discharge pipe 64 so that they correspond, thereby allowing the granules in the metering groove 631 to flow into the discharge pipe 64 and be guided to be output into the external dry powder inhaler container packaging, thus achieving quantitative filling. After all the granules in the metering groove 631 have been filled, the drive cylinder 69 drives the metering tube 63 back to the initial position to start the next round of granule filling process.

[0049] Preferably, a pneumatic hammer 67 is fixedly installed on the mounting plate 652. The pneumatic hammer 67 works to make the material in the cylinder 61 more compact, ensuring a stable amount of medicine granules for each filling.

[0050] Working principle:

[0051] After the medicinal powder is injected into the feed hopper 24, it is conveyed to the screen cylinder 31 by the conveying screw 22. The high-speed rotating scraper 33 inside the screen cylinder 31, in conjunction with the first screen 32, initially forms the medicinal powder into granules. The granular medicinal powder falls through the sieve holes on the first screen 32 to the left end of the discharge plate 41. Under the vibration of the linear vibrator 44, the medicinal particles roll along the discharge plate 41, gradually spherizing. When the medicinal particles roll out from the right end of the discharge plate 41, they fall onto the screen plate 51. After being sieved by the screen plate 51, the residual medicinal powder is sieved out and falls onto the powder discharge trough 59. Under the oscillation of the powder discharge trough 59, the medicinal powder gradually moves to the discharge end. The feed tube 510 collects the medication, while the granules roll on the screen plate 51 to the discharge port and fall into the feed cylinder 61. After being guided and gathered by the conical surface of the feed cylinder 61, the granules fall into the metering groove 631. Once the metering groove 631 is full, the drive cylinder 69 operates, causing the metering feed tube 63 to rise and discharge the granules to the filling hole 632 and even the upper inlet of the discharge tube 64, thereby exporting the granules to the external dry powder inhaler container packaging, completing the filling process. After all the granules in the metering groove 631 have been exported, the metering feed tube 63 returns to its initial position for the next round of filling, thus completing the entire continuous production process.

[0052] The above description is merely an embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural or procedural transformations made based on the content of the present invention's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present invention.

Claims

1. A dry granulation and filling apparatus, characterized by, The device comprises a rack (1), a feeding device (2), a scraper screen device (3), a vibrating spheroidizing device (4), a filtering screen device (5) and a metering filling device (6); The feeding device (2), the scraper screen device (3), the vibrating spheroidizing device (4), the filtering screen device (5) and the metering filling device (6) are all supported by the rack (1) and arranged in sequence along the flow direction of the granular material; The feeding device (2) is fixedly arranged on one side of the rack (1); The scraper screen device (3) is arranged on one side of the feeding device (2) and fixed on the rack (1); One end of the vibrating spheroidizing device (4) is arranged below the discharge port of the scraper screen device (3), the other end is arranged above the filtering screen device (5), and the vibrating spheroidizing device (4) is fixed on the rack (1); The filtering screen device (5) is arranged below the discharge port of the vibrating spheroidizing device (4) and fixed on the rack (1); The metering filling device (6) is arranged below the discharge port of the filtering screen device (5) and fixedly connected with the rack (1); In operation, the powder material is conveyed by the feeding device (2) to the scraper screen device (3), the powder material is preliminarily made into granular material by the scraper screen device (3) and conveyed to the vibrating spheroidizing device (4), so that the granular material gradually changes into spherical shape when moving in the vibrating spheroidizing device (4), then conveyed to the filtering screen device (5), after the filtering screen device (5) screens the granular material and residual powder, the filtering screen device (5) conveys the granular material to the metering filling device (6) for quantitative filling, and simultaneously collects the screened residual powder material; The metering filling device (6) comprises a mounting base (65), a fourth support (68) and a metering structure; The mounting base (65) is fixedly arranged in the rack (1); The fourth support (68) is fixed on the mounting base (65); The metering structure is fixed on the fourth support (68); The metering structure comprises a driving cylinder (69), a barrel (61) and a metering pipe (63); The driving cylinder (69) and the barrel (61) are both fixed on the fourth support (68); A blocking pipe (62) is arranged below the barrel (61); A discharge pipe (64) is arranged on one side of the blocking pipe (62); The metering pipe (63) is arranged in the blocking pipe (62) and slidably connected with the blocking pipe (62), and the lower part of the metering pipe (63) is fixed on the driving cylinder (69); A metering groove (631) is arranged in the metering pipe (63); A filling hole (632) is arranged on one side of the metering groove (631) and matched with the pipe opening of the discharge pipe (64); The scraper screen device (3) comprises a second support (34), a second driving motor (36) and a granulating structure; The granulating structure comprises a clamping ring (35), a screen cylinder (31) and a scraping shaft (37); The clamping ring (35) is fixedly connected with the second support (34) through the connecting plates arranged on both ends of the clamping ring (35); The screen cylinder (31) is arranged in the clamping ring (35) and is fixed below the second driving motor (36) through the clamping ring (35); The screen cylinder (31) is internally provided with a first screen (32); The upper end of the scraping shaft (37) is connected with the second driving motor (36), and the lower end is provided with a rotary scraper (33); The rotary scraper (33) is arranged in the screen cylinder (31) and has a gap with the first screen (32).

2. The dry granulation and filling equipment according to claim 1, characterized in that, The second support (34) is fixed on the rack (1); The second driving motor (36) is fixed on the upper end of the second support (34); The granulation structure is located below the second driving motor (36) and is fixed on the second support (34).

3. The dry granulation and filling apparatus according to claim 1, wherein The feeding device (2) comprises a first driving motor (25) and a first support (23) fixed on the rack (1); The first driving motor (25) is fixed on the upper end of the first support (23); The right side of the first driving motor (25) is provided with a conveying pipe (21); The conveying pipe (21) is provided with a feeding hopper (24) and a conveying screw (22) arranged inside; The conveying screw (22) is fixedly connected with the output shaft of the first driving motor (25).

4. The dry granulation and filling apparatus according to claim 1, wherein The vibrating balling device (4) comprises a support base, a linear vibrator (44) and a discharging plate (41); The support base is fixed on the rack (1); The linear vibrator (44) is fixed on the support base; The discharging plate (41) is provided with first baffles (45) on both sides and is fixed on the linear vibrator (44); The left end of the discharging plate (41) is higher than the right end, and the left end is located below the screen cylinder (31) and the right end is located above the filtering screen device (5).

5. The dry granulation and filling apparatus according to claim 1, wherein The filtering screen device (5) comprises a third support (52) fixed on the rack (1), a third driving motor (55), a screening mechanism and a transmission mechanism; The third support (52) is provided with a sliding rail (53); The third driving motor (55) is fixed on one side of the third support (52); The screening mechanism is located above the third support (52) and is connected with the third support (52) through the sliding rail (53); One end of the transmission mechanism is connected with the third driving motor (55) and the other end is connected with the screening mechanism.

6. The dry granulation and filling apparatus according to claim 5, wherein The screening mechanism comprises a support frame (54), a screen plate (51) and a powder discharging chute (59); the transmission mechanism comprises a rotating wheel (56), an eccentric shaft (57) and a rocker (58); The support frame (54) is slidingly connected with the sliding rail (53); The powder discharging chute (59) is fixed on the support frame (54); The screen plate (51) is provided with second baffles (511) on both sides and is fixed on the powder discharging chute (59); The screen plate (51) and the powder discharging chute (59) are respectively provided with a discharging pipe (512) and a discharging pipe (510) at the ends. The rotating wheel (56) is fixed on the output shaft of the third driving motor (55); One end of the eccentric shaft (57) is fixedly connected with the rotating wheel (56), and the other end is rotatably connected with the rocker (58); The rocker (58) is rotatably connected with the support frame (54); The third driving motor (55) drives the rocker (58) to swing through the rotating wheel (56) and the eccentric shaft (57), thereby driving the support frame (54) to swing, and driving the screen plate (51) and the powder outlet chute (59) to swing, so as to realize the screening and collection of granular materials and residual powder materials.

7. The dry granulation and filling apparatus according to claim 1, wherein The mounting base (65) comprises a mounting bottom plate (651), a mounting top plate (652) and a rubber column (653); The mounting bottom plate (651) is fixedly connected with the rack (1); The rubber column (653) is fixed on the mounting bottom plate (651); The mounting top plate (652) is fixed on the rubber column (653) and is fixedly connected with the rack (1); A pneumatic hammer (67) is arranged on the mounting top plate (652) to make the material in the barrel (61) more compact.

Citation Information

Patent Citations

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