A composite textile structure for debridement and its use

Abstract

This invention relates to the field of wound debridement materials, and more particularly to a composite textile structure for wound debridement and its application. The composite textile structure for wound debridement includes a matrix; and pile fibers located on at least one side of the matrix, extending from the surface of the matrix, and composed of at least two types of fibers with different finenesses. The fibers are divided into coarse and fine fibers according to their fineness, and the coarse and fine fibers are combined to form pile fibers by mechanical or chemical methods. The fine fibers have a lower flexural modulus, a larger specific surface area, and a stronger ability to adsorb impurities; while the coarse fibers have a higher flexural modulus and provide stronger cleaning power. Furthermore, by limiting the mixing ratio of coarse and fine fibers, the fiber type, and the height ratio of the two, and by adjusting the different heights of multiple pile fibers on the matrix, different impurities can be adsorbed, achieving better debridement power and effect for various types of wounds.

Description

Technical Field

[0001] This invention relates to the field of wound cleaning materials technology, and in particular to a composite textile structure for wound cleaning and its application. Background Technology

[0002] A wound refers to damage or destruction of the skin and other tissues to varying degrees caused by various injury or pathogenic factors. With the development of industry and transportation, the occurrence of wounds such as lacerations, crushing injuries, and fractures is gradually increasing; with changes in lifestyle and the increase in average life expectancy, the incidence of chronic wounds such as diabetic foot, arterial ulcers, and venous ulcers is also increasing significantly.

[0003] Wound healing is a complex and orderly biological process, mainly including four stages: inflammatory response, wound reconstruction, wound epithelialization, and wound remodeling. It involves the joint participation of various inflammatory cells, growth factors, and extracellular matrix components. During wound healing, the presence of foreign bodies or necrotic tissue may lead to excessive or poorly growing granulation tissue due to infection, thus affecting epidermal growth and delaying wound healing. Therefore, it is necessary to perform wound debridement before treatment to remove contaminants from the wound surface and interior, reduce bacterial count, and prevent microbial colonization and infection. Debridement is one of the key techniques in wound treatment. It is a wound management technique that removes inactive tissue, necrotic tissue, foreign bodies, and poorly healing tissue that hinder healing. The principle is to minimize tissue damage and promote tissue repair and healing. Debridement can be categorized as: surgical debridement, conservative sharps debridement, mechanical debridement, autolytic debridement, enzymatic debridement, biological debridement, and combined debridement.

[0004] Patent No. ZL 201410039675.7, entitled "A Textile-Based Wound Cleaning Material and Its Manufacturing Method," provides a textile-based wound cleaning material and its manufacturing method. The material comprises a knitted composite structure, including a ground fabric and pile fibers. The pile fibers are located on the front side of the ground fabric, with their roots woven together and bonded to the ground fabric with an adhesive. The side of the material in contact with the wound has soft pile fibers, allowing for wound cleaning. Its high absorbency and cleaning ability remove foreign objects and necrotic tissue from the wound, while its good flexibility and breathability reduce pain during the cleaning process. The back side of the material uses a knitted composite structure, woven on a circular knitting machine and treated with an adhesive coating to ensure good dimensional stability, support, and anti-shedding properties. The material is edged to prevent secondary contamination caused by loose pile fibers or yarn.

[0005] However, the wool fiber in this patent is a single fiber with a fixed specific surface area and flexural modulus, thus its adsorption and debridement capabilities are also fixed. Due to the complexity of wounds—the depth, size, and shape vary—the required debridement force also differs. Using a single wool fiber is insufficient to adapt to various wound types, limiting its effectiveness and making it less suitable for complex wounds. Existing textile debridement materials can only provide a single debridement force, making it difficult to adapt to different wound conditions. Summary of the Invention

[0006] The main objective of this invention is to provide a composite textile structure for wound cleaning and its application, aiming to improve the technical problem that existing wound cleaning materials are difficult to adapt to various wounds and have a narrow range of applications.

[0007] To achieve the above objectives, the present invention proposes a composite textile structure for debridement, comprising a matrix;

[0008] The pile fiber is located on at least one side of the matrix, the pile fiber extends from the surface of the matrix, and the pile fiber is composed of at least two fibers with different finenesses;

[0009] The root of the pile fiber is fixed to the matrix by weaving or gluing; the pile fiber is made of a blend of fibers with different fineness; or, the pile fiber is formed by removing part of the material at a predetermined position of the fiber by mechanical or chemical subtractive methods; or, the pile fiber is formed by mechanically connecting the ends of fibers with different fineness.

[0010] The fleece fibers in this design consist of at least two fibers of different fineness. These fibers act on the patient's wound or subcutaneous tissue for wound debridement. Because they include at least two fibers of different fineness, they provide a higher flexural modulus than single-fiber materials, thus offering stronger cleaning and absorption capabilities. This makes them suitable for different types of wounds and provides excellent debridement for various wound types. The fleece fibers in this design can be composed of two, three, or four fibers of different fineness. The overall basis weight of this composite textile structure for wound debridement is 350–600 g / m². 2 The side length is approximately 5 to 25 cm.

[0011] Preferably, the fleece fiber is composed of a mixture of coarse and fine fibers; the linear density of the coarse fibers is 3 to 50 dtex, and the linear density of the fine fibers is 0.05 to 0.55 dtex.

[0012] Fleece fibers are preferably composed of two fibers with different finenesses, which makes material selection more convenient and improves wound cleaning. They are specifically divided into coarse fibers and (ultra)fine fibers according to different finenesses. Coarse fibers and fine fibers are combined to form a fiber composite structure (i.e., fleece fibers) through mechanical or chemical methods. Among them, fine fibers have a smaller bending modulus, a larger specific surface area, and a stronger ability to adsorb impurities, while coarse fibers have a larger bending modulus. By using two types of fibers with different finenesses in combination, the resulting composite textile structure has better wound cleaning power and effect, a wider range of applications, and better wound cleaning effect for various wound conditions.

[0013] Preferably, the ratio of coarse fibers to fine fibers in the mixture is 1:0.1 to 20. This ratio refers to the ratio of the number of fibers between coarse and fine fibers. Coarse and fine fibers have different wound-cleaning effects. This solution allows for adaptive adjustment of the mixing ratio of coarse and fine fibers to suit different wound conditions. Compared to coarse fibers, fine fibers are softer and more comfortable due to their finer fibers, larger specific surface area, higher flexural modulus, and smaller interfiber gaps. For wounds that are sensitive to pain, easily absorb fine impurities, or easily exude large amounts of fluid, a higher ratio of fine fibers can be set during mixing. For wounds with larger and more stubborn impurities, a higher ratio of coarse fibers can be set during mixing.

[0014] Preferably, the height ratio of the coarse fibers to the fine fibers is 1:0.1 to 10. Similarly, since coarse and fine fibers have different wound-cleaning effects, setting different heights for the two types of fibers can provide stronger cleaning power and further improve the wound-cleaning effect for different wounds.

[0015] Preferably, the height of the fibers is 5–20 mm; the height difference between adjacent fibers is 0–15 mm. Furthermore, the multiple fibers distributed on the matrix, formed by a combination of coarse and fine fibers, can be set at different heights, thereby adsorbing different impurities. The combination of different types of fibers achieves a wide range of debridement capabilities and effects, resulting in better debridement for various wound conditions.

[0016] Of course, multiple fibers formed by combining coarse and fine fibers can also be set to be highly consistent.

[0017] Preferably, the fibers are composite fiber structures with double or multiple layers arranged or combined. The fibers (including coarse and fine fibers, etc.) in this solution can be composite fiber structures, specifically including double-layer or multi-layer types. Double-layer types include parallel double-layer types and core-sheath types; multi-layer types include parallel multi-layer types, radial types, multi-core types, wood grain types, embedded types, island types, and split types. Preferably, orange-petal types, star-shaped types, gear types, and island types are used.

[0018] Preferably, the coarse fiber includes at least one of ramie fiber, bamboo fiber, polyester fiber and its derivatives, polyamide fiber and its derivatives, polylactic acid fiber and its derivatives, polyethylene fiber and its derivatives, polypropylene fiber and its derivatives, polystyrene fiber and its derivatives, polyphenylene sulfide fiber and its derivatives, and polyacrylonitrile fiber and its derivatives.

[0019] The fine fibers include at least one of polyester fibers and their derivatives, polyamide fibers and their derivatives, viscose fibers and their derivatives, polylactic acid fibers and their derivatives, polyethylene fibers and their derivatives, polypropylene fibers and their derivatives, polystyrene fibers and their derivatives, polyphenylene sulfide fibers and their derivatives, and polyacrylonitrile fibers and their derivatives. Coarse and fine fibers can be selected from the above fiber types to perform wound debridement for different wound conditions.

[0020] Preferably, the substrate is a woven fabric, knitted fabric, or nonwoven fabric, and the substrate is made of at least one material selected from polyester, nylon, Tencel, or viscose. The longitudinal density of the substrate is 25-65 rows / 5cm, and the transverse density is 15-40 rows / 5cm.

[0021] Preferably, the root of the pile fiber is fixed to the matrix by weaving or gluing; the pile fiber is made of a blend of fibers with different fineness; or, the pile fiber is formed by mechanically or chemically converting the fiber with the largest fineness into a fiber with a smaller fineness at a preset position; or, the pile fiber is formed by mechanically connecting the ends of fibers with different fineness.

[0022] The roots of the fibers can be fixed to the matrix by weaving or gluing. When gluing, at least one of the following adhesives is used: polyacrylate, polyurethane, epoxy resin, polyvinyl acetate, and modified derivatives of the above adhesives. When coating, the adhesive coating weight is 10–50 g / m². 2 .

[0023] Fleece fiber is a combination of coarse and fine fibers, which can be made by blending coarse and fine fibers. Alternatively, it can be a fiber combination (fleece fiber) formed by mechanically connecting one end of a coarse fiber to the end of a fine fiber. Mechanical connection methods include, but are not limited to, knotting, sewing, welding, grafting, spiral winding, gluing, and end-connection.

[0024] Coarse fibers can also be transformed into fine fibers through mechanical or chemical methods in predetermined areas (areas that need to be set as fine fibers), thus forming pile fibers. For example, local fibers of coarse fibers can be peeled off, retaining the original fine fibers to form a combination of coarse and fine fibers; or coarse fibers can be opened and transformed into fine fibers through mechanical or chemical methods, in which case the coarse and fine fibers are interconnected. Mechanical methods include, but are not limited to, heat-melting, napping, raising, ultrasonic, laser, and freezing techniques. Chemical methods include, but are not limited to, swelling and dissolving techniques.

[0025] Fiber opening also includes various mechanical or chemical methods, including but not limited to heat treatment—due to the structural differences of multiple components, there are differences in shrinkage rates, and heat treatment can be used to separate the coarse fibers; mechanical methods—using mechanical action (brushing, napping, needle punching, hydroentangling, and ultrasound, etc.) to peel off the coarse fiber components; swelling methods—using the shrinkage rates of different fiber components in different solvents to generate internal stress and weaken the adhesive force, thereby causing the coarse fiber components to peel off; dissolution methods—using the different solubility of fibers in chemical solutions (alkaline inorganic solutions, acidic inorganic solutions, organic solutions, hot water), placing the coarse fibers in the solution dissolves one component, leaving the other components, thus achieving fiber opening.

[0026] Pile fibers can be produced by weaving wool strips into pile, flocking, or by breaking the loops (filaments) into pile through methods such as cutting, pulling, or brushing.

[0027] Preferably, the composite textile structure may also have an edging material on at least one side (in practice, the edging material can be applied to all four sides) to increase the overall strength and aesthetics of the composite textile structure. The edging method includes, but is not limited to, sewing with thread or edging fabric, laser sealing, ultrasonic sealing, etc.; the sewing thread used for edging is at least one low-elasticity yarn of 300-900d polyester, nylon, Tencel, etc., and the edging fabric can also be a low-elasticity fabric of polyester, nylon, or Tencel.

[0028] This invention also proposes the application of the composite textile structure for wound cleaning as described in any of the above claims in the fields of medical wound cleaning materials, cleaning materials, or textile fabrics. The medical wound cleaning material can be a medical wound cleaning dressing for cleaning wounds; the cleaning material can be a dust cleaning product for precision components such as semiconductors and aerospace parts, or a household cleaning product; simultaneously, the composite textile structure can also be used as a conventional clothing fabric, thus having a wide range of applications.

[0029] Compared with the prior art, the composite textile structure for wound cleaning of the present invention has the following beneficial effects: The textile composite structure includes a matrix and pile fibers. The pile fibers are located on the front side of the matrix and are divided into coarse fibers and fine fibers according to different fineness. The coarse fibers and fine fibers are combined into a fiber composite structure, i.e., pile fibers, by mechanical or chemical methods. Among them, the fine fibers have a smaller bending modulus, a larger specific surface area, and a stronger ability to adsorb impurities; while the coarse fibers have a larger bending modulus and can provide stronger cleaning power. In addition, by limiting the mixing ratio of coarse and fine fibers, the fiber type, and the height ratio of the two, and by adjusting the different heights of multiple pile fibers on the matrix, different impurities can be adsorbed, so as to achieve better wound cleaning power and effect for various types of wounds. Attached Figure Description

[0030] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0031] Figure 1 This is a schematic diagram of one embodiment of the composite textile structure for debridement of the present invention;

[0032] Figure 2 This is a cross-sectional view of the fleece fibers in Example 1 of the composite textile structure for wound cleaning according to the present invention;

[0033] Figure 3 This is a cross-sectional view of the fleece fibers in Example 2 of the composite textile structure for wound cleaning according to the present invention;

[0034] Figure 4 This is a schematic diagram of the structure of Example 11-1 of the composite textile structure for debridement of the present invention;

[0035] Figure 5 This is a schematic diagram of the structure of the composite textile structure for debridement of the present invention in embodiments 11-2;

[0036] Figure 6 This is a schematic diagram of the composite textile structure used for wound cleaning in this invention when the fibers are in a "skin-core" configuration;

[0037] Figure 7 This is a schematic diagram of the composite textile structure used for wound cleaning in this invention when the fibers are arranged in a "parallel double-layer type";

[0038] Figure 8 This is a schematic diagram of the composite textile structure used for debridement in this invention when the fibers are "island-shaped".

[0039] Figure 9 This is a schematic diagram of the composite textile structure used for wound cleaning in this invention when the fibers are "split-shaped".

[0040] Figure 10 This is a schematic diagram of the composite textile structure used for wound cleaning in this invention when the fibers are arranged in a "parallel multi-layered" manner.

[0041] In the attached diagram: 1-matrix, 2-fiber, 21-coarse fiber, 22-fine fiber.

[0042] The realization of the objective, functional features and advantages of the present invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0043] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0044] Furthermore, the technical solutions of the various embodiments can be combined with each other, but only if they are feasible for those skilled in the art. If the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0045] A composite textile structure for wound debridement, comprising:

[0046] Substrate 1; the substrate 1 is a woven fabric, knitted fabric or nonwoven fabric, and the substrate 1 is made of at least one material selected from polyester, nylon, Tencel or viscose.

[0047] A pile fiber 2 is located on at least one side of the matrix 1, extending from the surface of the matrix 1, and is composed of at least two fibers with different finenesses. The root of the pile fiber 2 is fixed to the matrix 1 by weaving or gluing; the height of the pile fiber 2 is 5-20 mm; adjacent pile fibers 2 have the same height; or, the height difference between adjacent pile fibers 2 is 5-15 mm.

[0048] The pile fiber 2 is composed of coarse fiber 21 and fine fiber 22; specifically, the pile fiber 2 is composed of a blend of fibers of different fineness; or, the pile fiber 2 is formed by removing part of the material at a predetermined position of the fiber by mechanical or chemical subtractive methods; or, the pile fiber 2 is formed by mechanically connecting the ends of fibers of different fineness.

[0049] The linear density of the coarse fiber 21 is 3-50 dtex, the linear density of the fine fiber 22 is 0.05-0.55 dtex, the ratio of the coarse fiber 21 to the fine fiber 22 is 1:0.1-20, the height ratio of the coarse fiber 21 to the fine fiber 22 is 1:0.1-10 (preferably 0.1-5), and the coarse fiber 21 has a double-layer or multi-layer composite fiber structure.

[0050] The coarse fiber 21 includes at least one of ramie fiber, bamboo fiber, polyester fiber and its derivatives, polyamide fiber and its derivatives, polylactic acid fiber and its derivatives, polyethylene fiber and its derivatives, polypropylene fiber and its derivatives, polystyrene fiber and its derivatives, polyphenylene sulfide fiber and its derivatives, and polyacrylonitrile fiber and its derivatives.

[0051] The fine fiber 22 includes at least one of polyester fiber and its derivatives, polyamide fiber and its derivatives, viscose fiber and its derivatives, polylactic acid fiber and its derivatives, polyethylene fiber and its derivatives, polypropylene fiber and its derivatives, polystyrene fiber and its derivatives, polyphenylene sulfide fiber and its derivatives, and polyacrylonitrile fiber and its derivatives.

[0052] The technical solution of the present invention will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are only used to explain the present invention and are not intended to limit the present invention.

[0053] Example 1

[0054] A composite textile structure for debridement includes a matrix 1; the matrix 1 is a knitted fabric (weft plain knit) made of polyester fibers.

[0055] The pile fiber 2 is located on the front side of the matrix 1 and extends from the surface of the matrix 1. The root of the pile fiber 2 is fixed to the matrix 1 by weaving. The pile fiber 2 is a long-pile pile structure woven from slivers, and is made of short fiber slivers of split-type polyester / nylon composite fiber—PET (polyester fiber) / PA6 (polyamide fiber). The pile fiber height is 5-8mm.

[0056] In this embodiment, the pile fiber 2 is composed of two fibers with different finenesses. Specifically, one end of the coarse fiber 21 is chemically split to form the fine fiber 22, thus forming the pile fiber 2. The coarse fiber 21 has an orange-petal-shaped composite fiber structure. The coarse fiber 21 is split in an alkaline solution with sodium hydroxide as the main component. The end of the coarse fiber 21 away from the matrix 1 is immersed in the alkaline solution and then heated to boiling for 30 minutes. At this time, the nylon (polyamide fiber) coarse fiber 21 is broken down, thus achieving splitting. After splitting, the coarse fiber 21 immersed in the alkaline solution is transformed into a fine fiber 22 containing an orange-petal-shaped composite fiber structure and with a smaller fineness. The un-immersed portion of the pile fiber (coarse fiber 21) retains its original fineness. After washing and drying, the pile fiber 2 with a special structure is obtained.

[0057] The linear density of the coarse fiber 21 is 25-35 dtex, and the linear density of the fine fiber 22 is 0.1-0.25 dtex (Note: Due to the manufacturing process and reaction degree, the fineness of the coarse and fine fibers is not a single value, but slightly different). The ratio of the number of coarse fibers 21 to fine fibers 22 is 1:1, and the height ratio of coarse fiber 21 (height 1-3 mm) to fine fiber 22 (height 1-5 mm) is 1:0.2-3 (Note: Because the height of the pile fiber / original coarse fiber is different, and it is easily affected by external interference when immersed in alkaline solution, the fine fibers obtained after immersion in alkaline solution are not completely the same height, but are within the above range).

[0058] As attached Figure 2 As shown, the fleece fiber in Example 1 has a PET / PA6 orange-petal-shaped composite fiber structure, wherein A1 is PET fiber and A2 is PA6 fiber.

[0059] Example 2

[0060] A composite textile structure for debridement includes a matrix 1; the matrix 1 is a knitted fabric (weft plain knit) made of polyester fibers.

[0061] The pile fiber 2 is located on the front side of the matrix 1 and extends from the surface of the matrix 1. The root of the pile fiber 2 is fixed to the matrix 1 by adhesive. The pile fiber 2 is a long pile structure obtained by cutting the filament and is made of filaments of island-type COPET (copolyester fiber) / PA (polyamide fiber) composite fiber (wherein, COPET fiber is the sea and PA fiber is the island).

[0062] In this embodiment, the pile fiber 2 is composed of two fibers with different finenesses. Specifically, one end of the coarse fiber 21 is chemically opened to form the pile fiber 22. The coarse fiber 21 has an island-type composite fiber structure. The coarse fiber 21 is opened in an alkaline solution with sodium hydroxide as the main component. The end of the coarse fiber 21 away from the matrix 1 is immersed in the alkaline solution and then heated to boiling for 30 minutes. The COPET fibers in the coarse fiber immersed in the alkaline solution are dissolved, thereby transforming the end immersed in the alkaline solution into PA island-type fine fibers 22, thus achieving fiber opening. The fineness of the PA island-type fine fibers 22 decreases, while the un-immersed portion of the pile fiber (coarse fiber 21) retains its original fineness. After washing and drying, the pile fiber 2 with a special structure is obtained.

[0063] The monofilament linear density of coarse fiber 21 is 30-50 dtex, the monofilament linear density of fine fiber 22 is 0.15-0.35 dtex, the ratio of coarse fiber 21 to fine fiber 22 is 1:1, and the height ratio of coarse fiber 21 (height 1-3 mm) to fine fiber 22 (height 2-5 mm) is 1:0.2-1.5.

[0064] As attached Figure 3 As shown, in Example 2, the initial state of the fleece fiber is a COPET / PA island-type composite fiber structure, wherein B1 is COPET fiber and B2 is PA fiber.

[0065] Example 3

[0066] All parameters and preparation steps in this embodiment are consistent with those in Example 1, except that: the pile fiber 2 in this embodiment is made of three different finenesses of fiber: coarse, medium and fine. The end of the coarse fiber 21 away from the matrix 1 is immersed in an alkaline solution and then heated to boiling for 30 minutes; the end of the coarse fiber 21 away from the matrix 1 is immersed in an alkaline solution again and then heated to boiling for 30 minutes. In this way, a pile fiber composed of coarse fiber 21, medium fiber and fine fiber 22 is obtained.

[0067] The monofilament linear density of coarse fiber 21 is 33-50 dtex, the monofilament linear density of medium fiber is 10-25 dtex, and the monofilament linear density of fine fiber 22 is 0.25-0.5 dtex. The ratio of coarse fiber 21, medium fiber and fine fiber 22 when mixed is 1:1:1, and the height ratio of coarse fiber 21, medium fiber and fine fiber 22 is 1:(0.5-2):(0.2-1).

[0068] Comparative Example 1

[0069] All parameters and preparation steps of this comparative example are consistent with those of Example 1, except that the fiber 2 (coarse fiber 21) in this example has not undergone chemical fiber opening treatment, that is, it is coarse fiber 21.

[0070] Comparative Example 2

[0071] All parameters and preparation steps of this comparative example are consistent with those of Example 1, except that: in this example, the fibers 2 (coarse fibers 21) are completely immersed in alkaline solution for chemical fiber opening treatment, that is, the coarse fibers 21 are completely transformed into fine fibers 22.

[0072] The composite textile structures (dressings) used for debridement in Examples 1-3 and Comparative Examples 1-2 were subjected to performance testing. The specific test results are shown in the table below:

[0073]

[0074] Note: 1. The above test of debridement effect mainly tests the colony count of the skin model after the action of the composite textile structure (dressing), specifically including the following steps: 1) Inoculate Pseudomonas aeruginosa into tryptic soy broth and incubate at 30℃~35℃ for 24h; 2) Dilute the culture with 0.9% sterile sodium chloride solution to prepare a bacterial suspension with ≤100 cfu per ml; 3) Take 10 sterilized silicone skin models and evenly drop 1 ml of the above bacterial suspension onto each model; 4) After wiping the models with the dressings of the examples and comparative examples, wash off the residual bacterial solution with 100 ml of 0.9% sterile sodium chloride solution and collect it in a 20*22cm sterile bag. After membrane filtration according to Chinese Pharmacopoeia 1105, take the filter membrane for culture. Perform the operation twice in parallel; 5) Take 1 ml of the above bacterial suspension, filter it directly with a membrane, take the filter membrane for culture, and then incubate at 30~35℃ for 3 days, and count the colonies. The lower the number of bacterial colonies in the above test data, the better the debridement effect.

[0075] 2. The first type of silicone skin model is used to simulate the first type of wound. 100 uniform (1×1mm) grid-like scratches are mechanically cut into the surface of the silicone skin model to simulate an uneven wound. The second type of silicone skin model is used to simulate the second type of wound. The surface is not specially treated to simulate smooth skin.

[0076] The test results in the table above show that the number of bacterial colonies growing in the culture medium after applying the composite textile structure (dressing) for wound debridement according to this scheme is relatively small, indicating that the composite textile structure for wound debridement prepared according to this scheme has a good debridement effect on wounds. The constituent fibers can be the two fibers with different finenesses shown in Examples 1-2, or the three fibers with different finenesses shown in Example 3. Of course, in other examples, four fibers with different finenesses can also be used, which are not listed here.

[0077] The test results from Example 1 and Comparative Example 1 show that when the fluff fibers are entirely composed of coarse fibers, the number of colonies growing in the culture medium is significantly higher than in Example 1. Furthermore, the recovery time of this dressing in actual wounds is longer than that of the dressing in this example, and the recovery effect is not as good. Similarly, the test results from Example 1 and Comparative Example 2 show that when the fluff fibers are entirely composed of finer fibers with even smaller fineness, the number of colonies growing in the culture medium is also higher than in Example 1, and the wound cleaning effect is relatively poor.

[0078] Example 4

[0079] In this embodiment, all preparation steps and process parameters are the same as in Example 1. The only difference is that the fineness of the two types of fibers (coarse fibers and fine fibers) that make up the pile fiber is different, as shown in the table below:

[0080] coarse fiber monofilament linear density Fine fiber monofilament linear density Example 1 25~35dtex 0.1~0.25dtex Example 4-1 5–15 dtex 0.1~0.2dtex Example 4-2 15~25dtex 0.2~0.3dtex Example 4-3 25~35dtex 0.3~0.4dtex Example 4-4 35~50dtex 0.4~0.55dtex Examples 4-5 52~60 dtex 0.47~0.58 dtex

[0081] The composite textile structure (dressing) for wound cleaning prepared in Example 4 above was subjected to performance testing, and the test results are shown in the table below:

[0082]

[0083] The test results from Example 4 above show that when the linear density of the coarse fiber monofilament is controlled at 3–50 dtex and the linear density of the fine fiber monofilament is controlled at 0.05–0.55 dtex, the number of colonies growing in the culture medium can be maintained below 20 CFU, demonstrating a certain cleaning effect. However, when the linear densities of the coarse and fine fibers constituting the wool fiber are 5–25 dtex and 0.1–0.3 dtex respectively, the wound cleaning effect is optimal, and the number of colonies growing in the culture medium is relatively low.

[0084] Example 5

[0085] In this embodiment, all preparation steps and process parameters are the same as in Example 1, except that the pile fiber is made of a blend of coarse and fine fibers, and the mixing ratio of the two types of fibers (coarse and fine fibers) is different, as shown in the table below:

[0086] The mixing ratio of coarse and fine fibers Example 1 1:1 Example 5-1 1:0.5 Example 5-2 1:3 Example 5-3 1:7 Example 5-4 1:10 Example 5-5 1:16

[0087] The composite textile structure (dressing) for wound cleaning prepared in Example 5 was subjected to performance testing, and the test results are shown in the table below:

[0088]

[0089] As shown in the test results of Example 5 above, besides needing to limit the fineness of coarse and fine fibers, the mixing ratio of coarse and fine fibers is also quite important. When the mixing ratio of coarse and fine fibers is 1:(10-20), the number of colonies in the culture medium is lower, resulting in a better wound cleaning effect. Experiments have shown that the preferred ratio of coarse to fine fibers in this scheme is 1:10-15, which has a stronger cleaning effect on wounds and a good wound cleaning effect on different types of wounds.

[0090] Example 6

[0091] In this embodiment, all preparation steps and process parameters are the same as in Example 1. The only difference is that the height ratio of the two types of fibers (coarse fibers and fine fibers) that make up the pile fiber is different, as shown in the table below:

[0092] coarse fiber height Fine fiber height The height ratio of the two Example 1 1~3mm 1~5mm 1:0.2～3 Example 6-1 0.5~1mm 5-6mm 1:5～12 Example 6-2 2-3mm 4~6mm 1:1.33～3 Example 6-3 3-4mm 2-3mm 1:0.5～1 Example 6-4 4-5mm 5-7mm 1:1.25～1.75 Example 6-5 4.5~5mm 0.5~1.5mm 1:0.1～0.33

[0093] The composite textile structure (dressing) for wound cleaning prepared in Example 6 was subjected to performance testing, and the test results are shown in the table below:

[0094]

[0095] As can be seen from the test results of Example 6 above, when the height difference between coarse and fine fibers is 1:0.5 to 1, the number of colonies in the culture medium is relatively small, indicating that the auxiliary material with this composite textile structure has a stronger cleaning effect on wounds and has a good debridement effect on different wounds.

[0096] Example 7

[0097] In this embodiment, all preparation steps and process parameters are the same as in Example 1, the only difference being the height of the constituent fibers, as detailed in the table below:

[0098] Fiber height / mm Example 1 5-8 Example 7-1 9-12 Example 7-2 11-15 Example 7-3 15-20 Example 7-4 23-26

[0099] The composite textile structure (dressing) for wound cleaning prepared in Example 7 was subjected to performance testing, and the test results are shown in the table below:

[0100]

[0101] The test results from Example 7 above show that the fibers are the main structure responsible for wound cleaning. Their height should be appropriate, neither too high nor too low; otherwise, the wound cleaning effect will be inadequate. Specifically, when the fiber height is 15-20 mm, the number of surviving bacterial colonies in the culture medium is lower, and this composite textile structure has a better wound cleaning effect.

[0102] Example 8

[0103] In this embodiment, all preparation steps and process parameters are the same as in Example 1. The only difference is that the height difference between adjacent fibers is different (and most fibers have the following height difference), as detailed in the table below:

[0104]

[0105]

[0106] The composite textile structure (dressing) for wound cleaning prepared in Example 8 was subjected to performance testing, and the test results are shown in the table below:

[0107]

[0108] As can be seen from the test results of Example 8 above, the fibers are the main structure for wound cleaning. When the height of each fiber is different, it can clean the wound at different heights. However, the height difference should not be too large, otherwise, the wound cleaning effect may be inadequate. Among them, a height difference of 2-10mm between adjacent fibers has a better wound cleaning effect.

[0109] Example 9

[0110] In this embodiment, all preparation steps and process parameters are the same as in Example 1. The only difference is the fiber structure, as detailed in the table below:

[0111]

[0112]

[0113] The composite textile structure (dressing) for wound cleaning prepared in Example 9 was subjected to performance testing, and the test results are shown in the table below:

[0114]

[0115] As can be seen from the test results of Example 9 above, the structure of the fibers (coarse and fine fibers) themselves also has a certain influence on the wound cleaning effect. Among various composite structures, when the fibers adopt the composite fiber structure of "orange petal type, island type, (gear type)", the number of colonies growing in the culture medium is less, and the wound cleaning effect is better.

[0116] Example 10

[0117] In this embodiment, all preparation steps and process parameters are the same as in Example 1. The only difference is that the fiber material used to prepare the fleece fibers is different, as detailed in the table below:

[0118] Fiber material Example 1 PET (polyester fiber) and PA6 (polyamide fiber) combination Example 10-1 Polyamide fiber and polypropylene fiber combination Example 10-2 Polystyrene fiber and polyamide fiber combination Example 10-3 Polyethylene fiber and polyester fiber combination Example 10-4 Polylactic acid fiber and polyphenylene sulfide fiber combination Examples 10-5 Polypropylene fiber and polyacrylonitrile fiber combination

[0119] The composite textile structure (dressing) for wound cleaning prepared in Example 10 was subjected to performance testing, and the test results are shown in the table below:

[0120]

[0121]

[0122] As can be seen from the test results of Example 10 above, the preferred material for preparing the fleece fiber is a composite material. When the fleece fiber (coarse fiber and fine fiber) is made using a composite material of "polyester fiber / polyamide fiber and polystyrene fiber / polyamide fiber", the number of colonies growing in the culture medium is less, resulting in a better wound cleaning effect.

[0123] Example 11

[0124] In this embodiment, all preparation steps and process parameters are the same as in Example 1. The only difference is the method of preparing the fleece fibers, as detailed in the table below:

[0125] Preparation method of fluff fiber Example 1 Chemical fiber opening, i.e., soaking in alkaline solution Example 11-1 It is made by direct blending of coarse and fine fibers. Example 11-2 It is made by bonding one end of coarse fibers and one end of fine fibers.

[0126] The composite textile structure (dressing) for wound cleaning prepared in Example 11 was subjected to performance testing, and the test results are shown in the table below:

[0127]

[0128] The test results from Example 11 above show that the combination of coarse and fine fibers in the preparation of the fluff fibers also affects the wound cleaning effect to some extent. The resulting (fine) fibers have different differences in density, softness, and mechanical properties. Among them, the "chemical fiber opening" method produces fluff fibers with more suitable density, softness, and mechanical properties, resulting in better wound cleaning effect.

[0129] Example 12

[0130] A composite textile structure for wound cleaning includes a matrix 1; the matrix 1 is a nonwoven fabric made of polyester fibers.

[0131] The pile fiber 2 is located on the front side of the substrate 1 and extends from the surface of the substrate 1. The root of the pile fiber 2 is fixed to the substrate 1 by weaving or gluing. The maximum height difference between the pile fibers 2 is 5 to 10 mm.

[0132] Furthermore, the pile fiber 2 is composed of at least two types of fibers with different fineness. Specifically, the pile fiber 2 includes coarse fibers 21 and fine fibers 22, and the fine fibers 22 are formed by chemically opening the coarse fibers 21 in the manner described in Example 1, i.e., by soaking them in an alkaline solution.

[0133] The linear density of the coarse fiber 21 is 5-15 dtex, and the linear density of the fine fiber 22 is 0.2-0.3 dtex. The ratio of coarse fiber 21 to fine fiber 22 when mixed is 1:11. The height ratio of coarse fiber 21 to fine fiber 22 is 1:0.5-1. Coarse fiber 21 and fine fiber 22 have an island-type composite fiber structure, which is composed of polyester fiber and polyamide fiber.

[0134] The composite textile structure (dressing) used for wound cleaning in Example 12 was subjected to performance testing. The specific test results are shown in the table below:

[0135]

[0136] The test results in the table above show that this scheme optimizes the fiber combination, mixing ratio, height ratio, height of the pile fiber, height difference between adjacent pile fibers, and the method of producing the pile fiber by optimizing the fiber combination, mixing ratio, height ratio, and the method of producing the pile fiber. At the same time, it limits the optimal fiber composite structure and fiber material. The number of colonies in the culture medium under the two different skin models is relatively small. That is, the composite textile structure used for debridement can achieve better debridement power and debridement effect for various types of wounds.

[0137] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A composite textile structure for wound debridement, characterized in that, include: Matrix (1); The pile fiber (2) is located on at least one side of the matrix (1), the pile fiber (2) extends from the surface of the matrix (1), and the pile fiber (2) is composed of at least two fibers with different finenesses; The root of the pile fiber (2) is fixed to the matrix (1) by weaving or gluing; the pile fiber (2) is a mixture of coarse fiber (21) and fine fiber (22); the fine fiber (22) is formed by removing part of the material from the end of the coarse fiber (21) away from the matrix (1) by a chemical subtractive method; The linear density of the coarse fiber (21) is 3 to 50 dtex, and the linear density of the fine fiber (22) is 0.05 to 0.55 dtex. The height ratio of the coarse fiber (21) to the fine fiber (22) is 1:0.1 to 10.

2. The composite textile structure for debridement as described in claim 1, characterized in that, The ratio of the coarse fiber (21) to the fine fiber (22) when mixed is 1:0.1 to 20.

3. The composite textile structure for debridement as described in claim 1, characterized in that, The height of the fleece fiber (2) is 5 to 20 mm; the height difference between adjacent fleece fibers (2) is 0 to 15 mm.

4. The composite textile structure for debridement as described in claim 1, characterized in that, The fiber has a double-layer or multi-layer composite fiber structure.

5. The composite textile structure for wound cleaning as described in any one of claims 1-4, characterized in that, The coarse fiber (21) includes at least one of ramie fiber, bamboo fiber, polyester fiber and its derivatives, polyamide fiber and its derivatives, polylactic acid fiber and its derivatives, polyethylene fiber and its derivatives, polypropylene fiber and its derivatives, polystyrene fiber and its derivatives, polyphenylene sulfide fiber and its derivatives, and polyacrylonitrile fiber and its derivatives. The fine fibers (22) include at least one of polyester fibers and their derivatives, polyamide fibers and their derivatives, viscose fibers and their derivatives, polylactic acid fibers and their derivatives, polyethylene fibers and their derivatives, polypropylene fibers and their derivatives, polystyrene fibers and their derivatives, polyphenylene sulfide fibers and their derivatives, and polyacrylonitrile fibers and their derivatives. The substrate (1) is a woven fabric, knitted fabric or nonwoven fabric made of at least one of polyester, nylon, Tencel or viscose.

6. The composite textile structure for debridement as described in any one of claims 1-4, characterized in that, The weaving method includes at least one of weaving wool strips into pile or breaking wool loops into pile; When the adhesive is used for fixation, the adhesive is at least one of polyacrylate and its derivatives, polyurethane and its derivatives, epoxy resin and its derivatives, and polyvinyl acetate and its derivatives, and the coating weight of the adhesive is 10-50 g / m². 2 ; The chemical subtractive material method includes at least one of swelling or dissolution.

7. The composite textile structure for debridement as described in any one of claims 1-4, characterized in that, The composite textile structure is edge-bound on at least one side; The edge binding method includes sewing edge binding with sewing thread or edge binding fabric, laser edge binding, or ultrasonic edge binding; the sewing thread used for edge binding is at least one of polyester, nylon, or Tencel thread of 300-900d, and the edge binding fabric is at least one of polyester, nylon, or Tencel fabric.

8. The application of a composite textile structure for debridement as described in any one of claims 1-7 in the field of medical debridement materials, cleaning materials or textile fabrics.

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