A Chinese medicine composition with heat-clearing and lung-nourishing effects, and its preparation method and application

Abstract

The invention discloses a Chinese medicine composition with the functions of clearing away heat and tonifying the lungs, and a preparation method and application thereof. The Chinese medicine composition has the functions of clearing away heat and tonifying the lungs, can effectively prevent and treat various upper respiratory tract infections, and improve human immunity.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with heat-clearing and lung-nourishing effects, which is formed by combining fermented liquid of traditional Chinese medicines such as honeysuckle and platycodon grandiflorum, as well as a preparation method and application thereof. Background Art

[0002] With the acceleration of industrialization and urbanization, the transportation is becoming more and more developed, the emission of various waste gases and dust in the atmosphere is increasing, and the air pollution is becoming more and more serious, resulting in an increase in the incidence of upper respiratory tract infections in the population year by year. Modern people are under increasing pressure in work and life, and their physical functions are gradually declining, and symptoms such as sputum, asthma, and cough will also follow. In existing clinical treatments, antibiotics or antiviral drugs are generally used. Although these drugs are effective quickly, antibiotic treatment can only inhibit or kill pharyngeal bacteria, and cannot eliminate the original lesions. The side effects are also large, and long-term use is prone to drug resistance and suppress immunity.

[0003] Therefore, the inventor has studied and developed a Chinese medicine composition with the effect of clearing heat and promoting lung function, which can clear the lung qi and make the lung function normally, thereby achieving the purpose of eliminating pathogens. The product is made of natural materials, safe and effective, and provides safer and more effective protection for patients. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition with the effects of clearing away heat and promoting lung function and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] The invention provides a traditional Chinese medicine composition with the effects of clearing away heat and promoting lung function. The raw materials of the traditional Chinese medicine composition include the following components: fresh medicinal material fermentation liquid of two or more components of honeysuckle, platycodon grandiflorum, houttuynia cordata, momordica grosvenori, dandelion, quinquefolius, polygonatum sibiricum, polygonatum odoratum, osmanthus fragrans, sea buckthorn and schizonepeta tenuifolia.

[0006] In order to achieve better effects, preferably, the raw materials of the Chinese medicine composition of the present invention are composed of the following components in parts by weight: 80-120 parts of honeysuckle, 60-120 parts of platycodon, 50-100 parts of houttuynia cordata, 30-70 parts of momordica grosvenori, 20-40 parts of dandelion, 15-20 parts of quinquefolius, 15-30 parts of polygonatum, 15-20 parts of polygonatum, 15-20 parts of osmanthus, 15-20 parts of sea buckthorn, and 15-20 parts of smilax china. The fresh medicinal material fermentation liquid of two or more components is mixed.

[0007] In order to achieve the best therapeutic effect, more preferably, the raw materials of the Chinese medicine composition are composed of the following components in weight: 100 parts of honeysuckle, 90 parts of platycodon, 80 parts of houttuynia cordata, 50 parts of momordica grosvenori, 30 parts of dandelion, 20 parts of quinquefolius, 20 parts of polygonatum, 20 parts of polygonatum, 20 parts of osmanthus, 20 parts of sea buckthorn, and 20 parts of fresh medicinal material fermentation liquid.

[0008] Another object of the present invention is to provide a method for preparing a Chinese medicine composition having the effects of clearing away heat and promoting lung function. The preparation method of the Chinese medicine composition involved in the present invention is as follows:

[0009] A. Selection of medicinal materials: Select fresh Chinese herbal medicines of each component: honeysuckle, platycodon grandiflorum, houttuynia cordata, momordica grosvenori, dandelion, quinquefolius, polygonatum, polygonatum odoratum, osmanthus, seabuckthorn and radix strychnifoliae. The fresh Chinese herbal medicines should have no mold spots, no discoloration, no peculiar smell and no rot on the surface, and set aside for use;

[0010] B. Cleaning of medicinal materials: Wash each fresh Chinese herbal medicine selected in step A with purified water, and dry the surface moisture of the medicinal materials;

[0011] C. Add ingredients: Put the Chinese herbal medicines cleaned in step B into sealed containers, add appropriate amounts of honey and purified water, and mix well;

[0012] D. Natural fermentation: placing the drugs in each sealed container in step C in a natural environment for natural fermentation for 180-240 days;

[0013] E. Mixing and preparation: Weigh two or more of the following fresh medicinal material fermentation products from the sealed containers in step D by weight: honeysuckle, platycodon grandiflorum, houttuynia cordata, momordica grosvenori, dandelion, quinquefolius, polygonatum, polygonatum odoratum, osmanthus fragrans, sea buckthorn and smilax glabra, mix them evenly to obtain the Chinese medicine composition of the present invention.

[0014] Preferably, the sealed container in step C is a food-grade plastic fermentation barrel or fermentation tank, and the weight ratio of the Chinese herbal medicine, honey and purified water is 3:1:10.

[0015] Preferably, the humidity of the natural fermentation of the drug in each sealed container in step D is 70%-80%, and the temperature is 30-40° C. Optimally, the sealed container should be placed in an environment with a temperature of 37° C.

[0016] Another object of the present invention is to provide a use of the Chinese medicine composition obtained by the above preparation method in preparing a heat-clearing and lung-nourishing product. The heat-clearing and lung-nourishing product is a medicine or health product for treating pneumonia or bronchitis.

[0017] According to a preferred embodiment of the present invention, at least the following beneficial effects are achieved:

[0018] The medicinal materials used in the present invention are all fresh medicinal materials, without drying and processing, and most of them are medicinal materials with the same origin as medicine and food. From the perspective of the formula, the Chinese medicine composition of the present invention is compatible with the principle of "monarch, minister, assistant and messenger" of traditional Chinese medicine, wherein honeysuckle, dandelion and polygonatum are compatible with clearing away heat and detoxicating, evacuating wind-heat, promoting body fluid and moistening dryness; plus Platycodon grandiflorum and Houttuynia cordata can relieve lung heat and dry cough, and then compatibility with Momordica grosvenori and Osmanthus fragrans can relieve cough and resolve phlegm, relieve throat and moisten the lungs, Polygonatum sibiricum and Prunus mume can invigorate the spleen and moisten the lungs, and eliminate dampness and eliminate phlegm; Seabuckthorn and Rhizoma Cynanchum have the effects of invigorating the spleen and nourishing the lungs, removing stasis and stopping bleeding, and reducing swelling and promoting tissue regeneration; all the medicines are used together to play the effects of dispersing wind and clearing heat, promoting lung and stopping cough, and removing stasis and stopping bleeding, thereby improving human immunity, and comprehensively achieving the purpose of treating respiratory tract infections in patients.

[0019] The composition of the present invention adopts pure Chinese medicine to treat respiratory tract infection of patients, has good clinical efficacy, has no toxic side effects, can significantly reduce the use of antibiotics by patients, and avoids the toxic side effects of Western antibacterial drugs; in addition, compared with the traditional extraction process, the preparation of the Chinese medicine composition of the present invention is fermented for a long time in a natural environment, consumes very little energy, saves production costs, and is safe and effective. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The following is a graph showing the swelling degree of mouse auricle inflammation in each group of samples in Experimental Example 1. DETAILED DESCRIPTION

[0021] In order to more clearly illustrate the present invention, the following examples are given, but they do not limit the scope of the invention in any way.

[0022] Example 1 Preparation of the oral liquid of the Chinese medicine composition of the present invention

[0023] The following components of fresh Chinese herbal medicines were selected: 3 kg each of honeysuckle, platycodon grandiflorum, houttuynia cordata, monk fruit, dandelion, five-fingered peach, polygonatum, polygonatum, osmanthus, sea buckthorn, and schizonepeta tenuifolia. The surfaces of the selected fresh Chinese herbal medicines had no mold spots, no discoloration, no peculiar smell, and no decay. The above fresh Chinese herbal medicines were washed with purified water, and the surface moisture of the medicinal materials was dried. Then they were respectively loaded into 30L food-grade plastic fermentation barrels, and honey and purified water were added to each fermentation barrel at a volume-to-weight ratio of 3:1:10, that is, honeysuckle, platycodon grandiflorum, houttuynia cordata, monk fruit, dandelion, five-fingered peach, polygonatum, and jade were added. 1kg of honey and 10kg of water are added to each barrel of bamboo, osmanthus, sea buckthorn and Rhizoma Cynanchum respectively, and after mixing evenly, each fermentation barrel is placed in an environment with an environmental humidity of 70%-80% and a temperature of 30-40°C for natural fermentation. After fermentation for 90 days, the fermentation liquid is taken from each fermentation barrel according to the following weight portions: 210ml of honeysuckle, 185ml of platycodon, 170ml of houttuynia cordata, 100ml of momordica grosvenori, 65ml of dandelion, 45ml of quinquefolius, 45ml of polygonatum, 45ml of polygonatum, 45ml of osmanthus, 45ml of sea buckthorn and 45ml of Rhizoma Cynanchum. Mix evenly to obtain 1000ml of the oral liquid of the present invention.

[0024] Example 2 Preparation of the oral liquid of the Chinese medicine composition of the present invention

[0025] The following components of fresh Chinese herbal medicines were selected: 3 kg each of honeysuckle, platycodon grandiflorum, houttuynia cordata, monk fruit, dandelion, five-fingered peach, polygonatum, polygonatum, osmanthus, sea buckthorn, and oxalis, and the surface of each selected fresh Chinese herbal medicine had no mold spots, no discoloration, no peculiar smell, and no decay; the above fresh Chinese herbal medicines were washed with purified water, and the surface moisture of the medicinal materials was dried; then they were respectively loaded into 50L fermentation tanks, and honey and purified water were added to each fermentation tank at a volume weight ratio of 3:1:10, that is, honeysuckle, platycodon grandiflorum, houttuynia cordata, monk fruit, dandelion, five-fingered peach, polygonatum, and polygonatum. , osmanthus, sea buckthorn, and Rhizoma Cynanchum respectively add 1kg of honey and 10kg of water, mix well, and place each fermentation tank in an environment with an environmental humidity of 70%-80% and a temperature of 37°C for natural fermentation. After fermentation for 30 days, take the fermentation liquid from each fermentation barrel according to the following weight amounts: 240ml of honeysuckle, 240ml of platycodon, 140ml of houttuynia cordata, 140ml of momordica grosvenori, 40ml of dandelion, 40ml of quinquefolius, 30ml of polygonatum, 30ml of polygonatum, 30ml of osmanthus, 30ml of sea buckthorn, and 40ml of Rhizoma Cynanchum; mix well to obtain 1000ml of the oral liquid of the present invention.

[0026] Example 3 Preparation of the Chinese medicine composition capsule of the present invention

[0027] From the fresh medicinal material fermentation barrel obtained in Example 1, the fermentation liquid was measured according to the following weight portions: 300 ml of honeysuckle, 210 ml of platycodon grandiflorum, 230 ml of momordica grosvenori, 130 ml of dandelion, 65 ml of polygonatum odoratum, and 65 ml of seabuckthorn, mixed evenly, concentrated under reduced pressure to form an extract, dried, crushed into powder, added with a suitable capsule excipient, and filled to obtain 100 capsules of the present invention.

[0028] Example 4 Preparation of the Chinese medicine composition granules of the present invention

[0029] The fermentation liquid was measured from the fresh medicinal material fermentation barrel obtained in Example 1 according to the following weight portions: 200 ml of honeysuckle, 280 ml of platycodon grandiflorum, 240 ml of houttuynia cordata, 70 ml of momordica grosvenori, 70 ml of polygonatum sibiricum, 50 ml of polygonatum odoratum, 50 ml of osmanthus fragrans, and 40 ml of smilax glabra, a total of 1000 ml, concentrated under reduced pressure to obtain an extract, dried, crushed into powder, added with a suitable granule excipient, and packaged to obtain 100 packets of the granules of the present invention.

[0030] Test Example 1 Anti-inflammatory test of the oral solution of the present invention

[0031] 1. Experimental Methods

[0032] 1.1 Sample preparation

[0033] A. Preparation of positive control drug solution: Dissolve aspirin powder in distilled water to dilute it into a 2.5 mg / mL solution;

[0034] B. Preparation of control sample solution: weigh the Chinese herbal medicine pieces of honeysuckle (fresh medicine water content 77.40%) 6.78g, Platycodon grandiflorum (fresh medicine water content 66.70%) 8.99g, Houttuynia cordata (fresh medicine water content 80.1%) 4.80g, Momordica grosvenori (fresh medicine water content 75.11%) 3.75g, Taraxacum officinale (fresh medicine water content 86.00%) 2.11g, Five-finger milk (Five-finger peach, fresh medicine water content 75.00%) 2.25g, Polygonatum sibiricum (fresh medicine water content 76.00%) 1.44g, Polygonatum odoratum (fresh medicine water content 71.00%) 1.74g, Osmanthus fragrans (fresh medicine water content 63.2%) 2.22g, Hippophae rhamnoides (fresh medicine water content 78.00%) 1.32g, Dioscorea paniculata (fresh medicine water content 60.03%) 2.40g, added 300 and 200ml pure water respectively, reflux extraction twice, the first reflux extraction for 1.5 hours, the second extraction for 1 hour, the extract was filtered through cotton, the filtrate was combined, and the volume was made up to 600ml as the control sample solution.

[0035] C. Preparation of sample solution: Take 300 ml of each enzyme solution, 300 ml of honeysuckle, 270 ml of platycodon grandiflorum, 240 ml of houttuynia cordata, 150 ml of momordica grosvenori, 150 ml of dandelion, 90 ml of milk vetch, 60 ml of polygonatum, 60 ml of polygonatum odoratum, 60 ml of osmanthus, 60 ml of sea buckthorn, and 60 ml of smilax china, mix them, recover part of the solvent under low temperature and reduced pressure, and fix the volume to 600 ml.

[0036] The control sample solution and the sample solution were taken as the high-dose group, diluted with water to 3 times the volume as the medium-dose group, and diluted with water to 6 times the volume as the low-dose group.

[0037] 1.2 Grouping and Dosing

[0038] 48 Kunming mice were randomly divided into blank control group, positive control group, high, medium and low dose groups of control sample solution and high, medium and low dose groups of sample solution, which were recorded as A, B, C, D, E, F, G and H groups, with 6 mice in each group. After 3 days of adaptive feeding, the mice were gavaged with the corresponding drugs for 7 days, once a day. Group A was given the corresponding volume of distilled water, and the administration volume was 0.6 ml / mouse.

[0039] 1.3 Study on the anti-auricular inflammation effect

[0040] The above 8 groups of mice were taken. One hour after the drug administration on the seventh day, 50 μl of xylene was evenly applied to the right auricle of each group of animals, and the left auricle was not treated as the control group. The mice were killed one hour later, and the two ears of the animals were cut along the ear baseline. The ear pieces were punched at the same part of the ear with a 8mm diameter puncher, and the ear pieces were weighed with a 1 / 1000 electronic balance to calculate the degree of ear swelling (the difference in weight between the left and right ear pieces). The swelling degree of the drug group and the control group was compared, and the inhibition rate of the drug on auricle swelling was calculated. The obtained data were subjected to inter-group t test.

[0041] Inhibition rate = (inflammation swelling degree of blank control group - inflammation swelling degree of drug-treated group) / inflammation swelling degree of blank control group

[0042] 2. Test results

[0043] The test results are shown in Table 1 and Figure 1 .

[0044] Table 1 Swelling degree of each group and its inhibition rate on swelling

[0045]

[0046] The test results show that: about 2 hours after inflammation in mice, both the samples of the present invention and the control samples can significantly inhibit the swelling of the mouse auricle; under the same dosage, the inhibitory effect of the samples of the present invention on the swelling of the mouse auricle is significantly better than that of the control sample.

[0047] Example 2: Clinical pharmacodynamics experiment

[0048] 1 Materials and methods

[0049] 1.1 General Information

[0050] Children with bronchial pneumonia and wind-heat blocking lung syndrome who were treated in the pediatric inpatient department of the First Affiliated Hospital of Hunan Traditional Chinese Medicine from March 2021 to March 2022 were selected as the research subjects. A total of 150 children were selected and met the inclusion criteria. According to the random number table method, the children were randomly divided into a positive control group, a control sample group, and a treatment group, with 50 cases in each group. The average age, course of disease, and weight of the three groups of children were compared, and there was no statistically significant difference (P>0.05), which was comparable, as shown in Table 2.

[0051] Table 2 Comparison of general information of patients

[0052]

[0053] 1.2 Diagnostic criteria

[0054] 1.1.1 Western medicine diagnostic criteria for bronchopneumonia in children

[0055] Formulated with reference to the "Four Diseases Prevention and Treatment Program for Children·Pneumonia Prevention and Treatment Program" and "Zhu Futang Practical Pediatrics (7th Edition)" issued by the National Health Commission of the People's Republic of China:

[0056] (1) General symptoms: sudden or delayed onset, with fever, loss of appetite, vomiting, lethargy, irritability, and shortness of breath

[0057] And other symptoms.

[0058] (2) Symptoms and signs of the respiratory system: cough and phlegm in the throat, increased breathing rate, common dyspnea, groaning during exhalation in severe cases, flaring of the nasal wings, three-point concave sign, and cyanosis around the mouth or nails. Chest signs may not be obvious in the early stage, but medium and coarse moist rales may be heard later. After a few days, fine moist rales or crackles may be heard; or tubular breath sounds may be heard.

[0059] (3) Chest X-ray: It may show nonspecific small patchy infiltration shadows of the lung parenchyma, which are more common in the lower lung fields, cardiophrenic angle area and middle inner zone, and may partially merge into large infiltration shadows.

[0060] (4) Blood picture: White blood cell count may be decreased, normal, or slightly increased.

[0061] 1.1.2 TCM Diagnosis of Pneumonia and Asthma

[0062] (1) Disease diagnosis

[0063] According to the Diagnosis and Efficacy Standards of Pediatric Diseases in Traditional Chinese Medicine, the diagnosis basis of pneumonia and asthma is:

[0064] a. The onset is relatively acute, with symptoms such as fever, cough, shortness of breath, nasal flaring, sputum, or mild cyanosis.

[0065] b. When the condition is serious, the patient may be short of breath, restless, have a pale complexion, have worsening cyanosis, or have a persistent high fever.

[0066] c. Children with congenital deficiencies often have a prolonged course of illness.

[0067] d. Lung auscultation reveals moderate to fine moist rales, often accompanied by dry rales or tubular breath sounds.

[0068] e. Blood picture: White blood cell count may be decreased, slightly increased or normal.

[0069] f. Chest X-ray: The lungs show increased and disordered texture, decreased transparency, or small flakes, spots, and blurred shadows.

[0070] It can appear as large uneven shadows.

[0071] (2) Syndrome diagnosis

[0072] According to the State Administration of Traditional Chinese Medicine's "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes·Standards for Diagnosis and Efficacy of TCM Pediatric Diseases and Syndromes"

[0073] Classification standard for wind-heat blocking the lungs syndrome in pneumonia with wheezing and cough.

[0074] Wind-heat blocking the lungs: fever, aversion to wind, slight sweating, thirst, cough, thick yellow sputum, rapid breathing, and red throat.

[0075] The tip of the tongue is red, the tongue coating is thin yellow, and the pulse is floating and rapid.

[0076] 1.1.3 TCM syndrome scoring criteria

[0077] This was formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines" issued by the State Administration of Traditional Chinese Medicine.

[0078] 1.2 Inclusion criteria

[0079] (1) Those who meet the above diagnostic criteria and are diagnosed with bronchial pneumonia due to wind-heat blocking the lungs;

[0080] (2) The duration of pneumonia does not exceed 48 hours;

[0081] (3) The highest body temperature within 24 hours before enrollment was ≥38.5°C;

[0082] (4) Aged 3 to 10 years; weight ≥ 14 kg;

[0083] (5) White blood cell count ≤ 10 × 109 / L, neutrophil ratio less than 70%;

[0084] (6) C-reactive protein: normal;

[0085] (7) Hospitalized patients;

[0086] (8) The child’s legal guardian provides informed consent and signs.

[0087] 1.3 Exclusion criteria

[0088] (1) Patients with concurrent heart, liver, kidney or other organ diseases;

[0089] (2) Patients with concurrent bacterial infection;

[0090] (3) Those who are unable to cooperate or are currently participating in clinical trials of other drugs;

[0091] (4) Those who are known to be allergic to the ingredients of this preparation;

[0092] (5) Depending on the doctor’s judgment, it is easy to lose patients to follow-up.

[0093] 2 Methods

[0094] 2.1 Treatment methods

[0095] Positive control group: Patients with bacterial infection were given cefuroxime sodium 80 mg / (kg·d) added to 5% glucose injection and intravenous drip twice a day; or ceftriaxone 80 mg / (kg·d) added to 5% glucose injection and intravenous drip once a day. Patients with mycoplasma infection were given intravenous drip of azithromycin 10 mg / (kg·d) added to 5% glucose injection and intravenous drip once a day for 5 consecutive days.

[0096] Control sample group: on the basis of the treatment of the positive control group, the drug solution prepared according to the preparation method of the control sample solution in Test Example 1 of the present invention was additionally taken, 1 dose of 15-30 ml per day, divided into 3 times for oral administration.

[0097] Treatment group: In addition to the treatment of the control group, the oral liquid of the composition of Example 1 of the present invention was taken orally, 1 dose of 15-30 ml per day, divided into 3 times. All three groups were treated for 7 days.

[0098] 2.2 Observation indicators

[0099] Formulated with reference to the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases":

[0100] Recovery: symptoms and signs disappear or almost disappear, syndrome score decreases by ≥95%, and lung X-ray reexamination is normal;

[0101] Markedly effective: symptoms and signs are significantly improved, the syndrome score is reduced by >70%, and the lesions have not been completely absorbed by lung X-ray examination;

[0102] Effective: Symptoms and signs are improved, the syndrome score is reduced by 70% to 30%, and the lesions are partially absorbed on lung X-ray examination;

[0103] Ineffective: There is no significant improvement in symptoms and signs, or they may even worsen; the syndrome score decreases by <30%; lung X-ray examination shows that the lesions are not absorbed or may even increase.

[0104] 2.3 Statistical methods

[0105] SPSS 17.0 statistical software was used. Qualitative data were described by frequency table, percentage or constituent ratio; quantitative data were described by mean ± standard deviation. Qualitative data were analyzed by χ2 test; quantitative data were analyzed by t test, and hypothesis testing was uniformly performed by two-sided test.

[0106] 3 Results

[0107] 3.1 Comparison of cough, fever and sputum accumulation scores before and after treatment in the three groups is shown in Table 3

[0108] Table 3 Comparison of disease symptom data of patients

[0109]

[0110] As can be seen from Table 2, the scores of cough symptoms, fever symptoms and sputum congestion symptoms in the three groups of patients were significantly reduced after treatment compared with those before treatment. In addition, the therapeutic effect of the treatment group was more significant than that of the control sample group, and the difference was statistically significant (P<0.05).

[0111] 3.2 Comparison of comprehensive efficacy among the three groups

[0112] At the end of treatment, the comparison of the marked control rate and total effective rate of the three groups of patients is shown in Table 4.

[0113] Table 4 Comparison of comprehensive treatment effects of patients

[0114]

[0115] The results showed that the treatment group had a marked control rate (cured + markedly effective) of 80% and a total effective rate of 96%, the control sample group had a marked control rate of 66% and a total effective rate of 82%, and the positive control group had a marked control rate of 58% and a total effective rate of 78%; the differences among the three groups were statistically significant (P < 0.05), indicating that the use of the composition of the present invention can more effectively control the patient's symptoms than the product obtained by the traditional preparation method.

Claims

1. A Chinese medicine composition having the effects of clearing away heat and promoting lung function, characterized in that: The raw materials of the Chinese medicine composition are composed of the following components by weight: 80-120 parts of honeysuckle, 60-120 parts of platycodon grandiflorum, 50-100 parts of houttuynia cordata, 30-70 parts of momordica grosvenori, 20-40 parts of dandelion, 15-20 parts of quinquefolius, 15-30 parts of polygonatum, 15-20 parts of polygonatum, 15-20 parts of osmanthus, 15-20 parts of sea buckthorn, and 15-20 parts of fresh medicinal material fermentation liquid. The preparation of the Chinese medicine composition specifically includes the following steps: A. Selection of medicinal materials: Select fresh Chinese herbal medicines of each component: honeysuckle, platycodon grandiflorum, houttuynia cordata, momordica grosvenori, dandelion, quinquefolius, polygonatum sibiricum, polygonatum odoratum, osmanthus fragrans, seabuckthorn, and radix strychnifoliae. The fresh Chinese herbal medicines should have no mold spots, no discoloration, no peculiar smell, and no rot on the surface, and set aside for use; B. Cleaning of medicinal materials: Wash each fresh Chinese herbal medicine selected in step A with purified water, and dry the surface moisture of the medicinal materials; C. Add ingredients: Put the Chinese herbal medicines cleaned in step B into sealed containers, add appropriate amounts of honey and purified water, and mix well; D. Natural fermentation: placing each sealed container in step C in a natural environment for natural fermentation for 30-240 days; E. Mixing and preparation: Weigh the following fresh medicinal material fermentation products from each sealed container in step D by weight: honeysuckle, platycodon grandiflorum, houttuynia cordata, momordica grosvenori, dandelion, quinquefolius, polygonatum, polygonatum odoratum, osmanthus, sea buckthorn, and smilax glabra, mix them evenly to obtain the product.

2. The Chinese medicine composition according to claim 1, characterized in that: The raw materials of the Chinese medicine composition are composed of the following components in parts by weight: 100 parts of honeysuckle, 90 parts of platycodon grandiflorum, 80 parts of houttuynia cordata, 50 parts of momordica grosvenori, 30 parts of dandelion, 20 parts of quinquefolius, 20 parts of polygonatum, 20 parts of polygonatum, 20 parts of osmanthus, 20 parts of sea buckthorn, and 20 parts of fresh medicinal material fermentation liquid.

3. The Chinese medicine composition according to claim 1, characterized in that In step C of preparing the traditional Chinese medicine composition, the sealed container is a food-grade plastic fermentation barrel or fermentation tank, and the weight ratio of the Chinese herbal medicine, honey and purified water is 3:1:

10.

4. The Chinese medicine composition according to claim 1, characterized in that: In the preparation step D of the traditional Chinese medicine composition, the humidity of the natural fermentation in each sealed container is 70%-80%, and the temperature is 30-40°C.

5. The Chinese medicine composition according to claim 4, characterized in that The temperature of natural fermentation in each sealed container is 37°C.

6. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of heat-clearing and lung-nourishing medicines.

7. The use according to claim 6, wherein the heat-clearing and lung-nourishing medicine is a medicine for treating pneumonia or bronchitis.

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