Magnetic separation device and sample analyzer

Abstract

The application provides a magnetic separation device and a sample analyzer, and relates to the technical field of detection equipment. The magnetic separation device comprises a base, a magnetic separation mechanism, a flow channel structure and a temperature control assembly arranged on the base. The flow channel structure is configured to inject liquid into the magnetic separation mechanism. The temperature control assembly controls the temperature of the magnetic separation mechanism and the flow channel structure. The temperature control assembly can heat the magnetic separation mechanism and the flow channel structure, so that corresponding heating mechanisms do not need to be arranged separately for the magnetic separation mechanism and the flow channel structure. In this way, the number of components of the magnetic separation device of the application can be reduced, the structure of the magnetic separation device is more compact, and the cost is lower. In the application, the magnetic separation mechanism and the flow channel structure can be heated simultaneously by the temperature control assembly, so that the number of heating devices is reduced, and the structure of the magnetic separation device of the application is more compact.

Description

Technical Field

[0001] This application relates to a magnetic separation device and a sample analyzer, belonging to the field of detection equipment technology. Background Technology

[0002] Magnetic separation equipment is a device that separates substances in an object by means of magnetic components. During the separation process, heated cleaning fluid is added to the object and the object is heated to improve the separation effect.

[0003] In related technologies, when performing the separation process of the analyte, the analyte and the cleaning solution need to be heated separately. This requires the magnetic separation equipment to be equipped with separate heating devices for the analyte and the cleaning solution, resulting in a complex structure and high cost for the magnetic separation equipment. Summary of the Invention

[0004] This application provides a magnetic separation device and a sample analyzer, which solves the problems of complex structure and high cost of magnetic separation equipment in related technologies.

[0005] In a first aspect, this application provides a magnetic separation device, comprising:

[0006] A base, and a magnetic separation mechanism, a flow passage structure, and a temperature control component disposed on the base, the flow passage structure being configured to inject liquid into the magnetic separation mechanism, the temperature control component controlling the temperature of the magnetic separation mechanism and the flow passage structure, the temperature control component including a heating element, at least a portion of the structure of the heating element being opposite to the magnetic separation mechanism.

[0007] In some embodiments, the flow passage structure and the magnetic separation mechanism respectively abut against the heating element; or, the magnetic separation mechanism abuts against the heating element, and the flow passage structure is disposed on the magnetic separation mechanism.

[0008] In some embodiments, the magnetic separation mechanism includes a mounting base and a magnetic separation assembly, wherein a magnetic separation chamber is disposed on the mounting base and the magnetic separation assembly is located within the magnetic separation chamber;

[0009] Both the heating element and the flow passage structure are mounted on the mounting base.

[0010] In some embodiments, the heating element is disposed on the bottom wall of the mounting base, and the flow passage structure is disposed on the side wall of the mounting base.

[0011] In some embodiments, the temperature control component further includes a heat insulation element disposed on the outer wall of the mounting base, and the heating element is located between the heat insulation element and the mounting base.

[0012] In some embodiments, the temperature control component further includes a detection element and a control element, wherein the heating element and the detection element are respectively connected to the control element, and the control element controls the switching on and off of the heating element and / or the heating temperature of the heating element according to the detection result of the detection element.

[0013] In some embodiments, the flow passage structure includes a delivery pipe and a liquid injection device, the liquid injection device being connected to the liquid outlet end of the delivery pipe;

[0014] The delivery pipeline includes at least one heat-conducting pipe, which is disposed on the mounting base.

[0015] In some embodiments, the delivery conduit further includes at least one connecting conduit connecting the outlet end of the heat-conducting conduit to the injection element; and / or, the connecting conduit connects between two heat-conducting conduits, enabling the two heat-conducting conduits to conduct.

[0016] In some embodiments, the heat-conducting conduit includes a main body and at least one connector communicating with the main body, at least a portion of the main body being disposed on the mounting base, and the connector extending outside the mounting base and connected to the connecting conduit.

[0017] In some embodiments, the side wall of the mounting base is provided with a fixing groove, and the heat conduction pipe is detachably connected in the fixing groove.

[0018] In some embodiments, the inner wall of the fixing groove is provided with a heat-conducting layer.

[0019] In some embodiments, the magnetic separation mechanism further includes a cover plate detachably connected to the opening of the magnetic separation chamber, the liquid injection element being disposed on the cover plate and extending into the magnetic separation chamber.

[0020] Secondly, this application provides a sample analyzer, including the magnetic separation device described above.

[0021] In the magnetic separation device provided in this application, the base can be used to support the magnetic separation mechanism, the flow path structure, and the temperature control component. The magnetic separation mechanism can be used for magnetic separation of samples, and the flow path structure can inject liquid into the magnetic separation mechanism to improve the magnetic separation effect of the sample. The temperature control component can simultaneously regulate the temperature of the magnetic separation mechanism and the flow path structure. That is, the temperature control component can heat the sample in the magnetic separation mechanism and also heat the liquid in the flow path structure. In this way, the flow path structure can inject heated liquid into the magnetic separation mechanism to further improve the magnetic separation effect. The temperature control component can heat both the magnetic separation mechanism and the flow path structure, thus eliminating the need to set up separate heating mechanisms for the magnetic separation mechanism and the flow path structure. This simplifies the structure of the magnetic separation device, making it more compact and lower in cost. Attached Figure Description

[0022] The above and other objects, features, and advantages of embodiments of this application will become more readily understood through the following detailed description with reference to the accompanying drawings. In the drawings, several embodiments of this application will be described by way of example and non-limitation, wherein:

[0023] Figure 1 This is a schematic diagram of the magnetic separation device according to an embodiment of this application;

[0024] Figure 2 This is a schematic diagram of the internal structure of the magnetic separation device according to an embodiment of this application;

[0025] Figure 3 This is a schematic diagram of the heating element of the magnetic separation device according to an embodiment of this application;

[0026] Figure 4 This is a schematic diagram of the mounting base for the magnetic separation device according to an embodiment of this application;

[0027] Figure 5 This is a schematic diagram of the support member of the magnetic separation device according to an embodiment of this application;

[0028] Figure 6 This is a top view of the support member of the magnetic separation device according to an embodiment of this application;

[0029] Figure 7 This is a schematic diagram of the flow path structure of the magnetic separation device according to an embodiment of this application;

[0030] Figure 8 This is a schematic diagram of the conveying pipeline of the magnetic separation device according to an embodiment of this application;

[0031] Figure 9 This is a schematic diagram of the cover plate of the magnetic separation device according to an embodiment of this application.

[0032] Figure label:

[0033] 100 - base, 110 - support.

[0034] 200-Magnetic separation mechanism, 210-Mounting base, 211-Magnetic separation chamber, 212-Fixing tank, 220-Bearing component, 221-Reaction cup bearing position, 222-Connecting shaft, 223-Waste liquid cup bearing position, 230-Magnetic component, 240-Cover plate, 241-Inlet / Outlet, 242-Suction port, 243-Fixing port, 244-Activation liquid port.

[0035] 300 - Flow path structure; 310 - Delivery pipe; 311 - Heat conduction pipe; 311a - Main body; 311b - Connector; 312 - Connecting pipe; 320 - Liquid injection component; 320a - First liquid injection component; 320b - Second liquid injection component; 320c - Third liquid injection component; 320d - Fourth liquid injection component.

[0036] 410 - Heating element, 420 - Insulation element, 421 - First insulation element, 422 - Second insulation element, 423 - Third insulation element, 430 - Detection element, 440 - Control element.

[0037] 500 - Reaction cup, 510 - Waste liquid cup

[0038] 600 - Drive assembly, 610 - First driver, 620 - Transmission component,

[0039] 700 - Liquid suction element, 710 - Liquid suction end, 700a - First liquid suction element, 700b - Second liquid suction element, 700c - Third liquid suction element.

[0040] 800 - Lifting assembly, 810 - Second drive, 820 - Mounting plate, 830 - Guide rod. Detailed Implementation

[0041] The embodiments of this application are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this application, and should not be construed as limiting this application.

[0042] In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0043] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0044] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between components; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0045] In this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0046] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0047] In the field of in-vitro diagnostics (IVD), such as chemiluminescence immunoassay analyzers and nucleic acid extractors, to determine whether a sample contains a target analyte, the target analyte is typically extracted first. Then, labeled substances are added to trigger a reaction that produces a light or color signal. The intensity of the signal is measured to determine the concentration. Target analyte extraction often uses magnetic microparticles, where a substance that specifically binds to the target analyte is added to the magnetic microparticles. The sample and magnetic microparticles are added to a reaction vessel to react. If the sample contains the target analyte, it binds to the magnetic microparticles. Magnetic separation cleaning technology uses magnetic separation equipment to clean the reaction vessel of interfering substances other than the magnetic microparticles and the target analyte. During the cleaning process, a heated cleaning solution is added to the reaction vessel.

[0048] In related technologies, the sample to be tested and the cleaning solution are heated separately during magnetic separation. This requires the magnetic separation equipment to be equipped with at least two independent heating devices to heat the sample to be tested and the cleaning solution separately, resulting in a complex structure and high cost for the magnetic separation equipment.

[0049] In the magnetic separation device proposed in this application, a base can be used to support the magnetic separation mechanism, the flow path structure, and the temperature control component. The magnetic separation mechanism is used for magnetic separation of samples, and the flow path structure can inject liquid into the magnetic separation mechanism. The temperature control component can simultaneously regulate the temperature of the magnetic separation mechanism and the flow path structure; that is, the temperature control component can heat the sample in the magnetic separation mechanism and also heat the liquid in the flow path structure. This allows the flow path structure to inject heated liquid into the magnetic separation mechanism, further enhancing the magnetic separation effect. The temperature control component can simultaneously heat both the magnetic separation mechanism and the flow path structure, eliminating the need for separate heating mechanisms for each. This simplifies the structure of the magnetic separation device, making it more compact and cost-effective.

[0050] The sample analyzer proposed in this application includes the magnetic separation device mentioned above, thus the structure of the sample analyzer is more compact, and the manufacturing cost of the sample analyzer is relatively lower.

[0051] The magnetic separation device and sample analyzer provided in this application will be described in detail below with reference to specific embodiments.

[0052] This application provides a magnetic separation device, with reference to... Figures 1-3 As shown, it includes a base 100, a magnetic separation mechanism 200, a flow path structure 300, and a temperature control component. This magnetic separation device can be applied in sample analyzers.

[0053] The base 100 serves as the fundamental component of the magnetic separation device of this application, and can provide a mounting base for at least some other components of the magnetic separation device. A reaction vessel containing a sample of the reaction mixture is placed within the magnetic separation mechanism 200, which performs magnetic separation on the sample to extract the target analyte and clean other interfering substances from the reaction vessel. The flow path structure 300 is configured to inject cleaning fluid into the magnetic separation mechanism 200 to remove excess impurities from the sample.

[0054] The temperature control component can control the temperature of the magnetic separation mechanism 200 and the flow path structure 300. Specifically, the temperature control component can simultaneously control the temperature of the sample in the magnetic separation mechanism 200 and the temperature of the cleaning solution in the flow path structure 300, so that the sample in the magnetic separation mechanism 200 and the cleaning solution in the flow path structure 300 can be heated by only one temperature control component. This reduces the number of components in the magnetic separation device of this application, making the structure of the magnetic separation device more compact and the manufacturing cost relatively lower.

[0055] In some implementations, reference Figures 1-3 As shown, the magnetic separation mechanism 200 of this application may specifically include a mounting base 210, a magnetic separation component, and a cover plate 240. The mounting base 210 is the basic component of the magnetic separation mechanism 200, and at least some other components of the magnetic separation mechanism 200 may be disposed on the mounting base 210. A magnetic separation chamber 211 is disposed inside the mounting base 210. The magnetic separation chamber 211 is a cavity structure within the mounting base 210. The magnetic separation component and the reaction cup 500 containing the sample are both placed inside the magnetic separation chamber 211. The magnetic separation component can perform magnetic separation operations on the sample in the reaction cup 500. The mounting base 210 also has an opening communicating with the magnetic separation chamber 211. The cover plate 240 is detachably disposed on the opening of the mounting base 210, so that the cover plate 240 can close the magnetic separation chamber 211 or the magnetic separation chamber 211 can be opened by removing the cover plate 240.

[0056] The temperature control component is configured to heat the mounting base 210 and the magnetic separation chamber 211 within the mounting base 210. When the temperature control component heats the mounting base 210, the increased temperature of the mounting base 210 causes a corresponding increase in the temperature of the magnetic separation chamber 211 within the mounting base 210, thus heating the sample located within the magnetic separation chamber 211. A cover plate 240 is provided over the opening of the mounting base 210 to maintain the temperature within the magnetic separation chamber 211.

[0057] In some implementations, reference Figure 2 and Figure 3 As shown, the magnetic separation assembly of this application can be specifically configured to include a carrier 220 and multiple magnetic components 230. Both the carrier 220 and the multiple magnetic components 230 are disposed within the magnetic separation chamber 211 of the mounting base 210. The carrier 220 can be used to support the reaction cup 500. Specifically, a reaction cup support position 221 can be provided on the carrier 220, and the reaction cup 500 can be fixed to the reaction cup support position 221. The flow passage structure 300 can inject cleaning fluid into the reaction cup 500 located at the reaction cup support position 221. The reaction cup support position 221 on the carrier 220 can specifically be a cavity formed on the carrier 220, and the shape of the cavity matches the shape of the reaction cup 500, so that the reaction cup 500 can be placed in the reaction cup support position 221.

[0058] In this application, the carrier 220 is rotatably disposed within the magnetic separation chamber 211 of the mounting base 210. Multiple magnetic elements 230 can be provided, specifically disposed on the bottom wall of the magnetic separation chamber 211 and arranged along the rotation direction of the carrier 220. Rotation of the carrier 220 allows its reaction cup bearing position 221 to rotate relative to any of the magnetic elements 230, thus enabling the reaction cup bearing position 221 to approach multiple magnetic elements 230 respectively. The smaller the distance between the magnetic element 230 and the reaction cup bearing position 221, the better the magnetic separation effect of the magnetic element 230 on the sample within the reaction cup 500. Furthermore, the rotation of the reaction cup bearing position 221 by the carrier 220 allows the reaction cup 500 on the reaction cup bearing position 221 to sequentially approach and face multiple magnetic elements 230, thereby allowing the sample within the reaction cup 500 to be magnetically attracted multiple times by the multiple magnetic elements 230, further improving the sample separation effect.

[0059] Multiple reaction cup support positions 221 can also be provided on the support member 220, so that the support member 220 can hold multiple reaction cups 500 to improve detection efficiency. Among them, the multiple reaction cup support positions 221 can be arranged sequentially at intervals along the rotation direction of the support member 220, and any reaction cup support position 221 can be sequentially opposite and close to multiple magnetic components 230, so that the sample in the reaction cup 500 has a better magnetic separation effect and can improve the magnetic separation efficiency of the magnetic separation device.

[0060] Specifically, the reaction cup support position 221 of the support member 220 is located near the inner wall of the magnetic separation chamber 211, and multiple magnetic elements 230 are located on the side of the reaction cup support position 221 facing away from the inner wall of the magnetic separation chamber 211, so that the multiple reaction cup support positions 221 can surround the multiple magnetic elements 230. The bottom of the support member 220 can be configured to have a certain distance from the bottom wall of the magnetic separation chamber 211, so as to reduce the friction force on the support member 220 when it rotates. The bottom wall of the magnetic separation chamber 211 can also have a groove structure, and part of the support member 220 can be embedded in the groove structure of the bottom wall of the magnetic separation chamber 211, thereby limiting the position of the support member 220 when it rotates, so that the support member 220 rotates smoothly and stably.

[0061] In some implementations, reference Figure 1 and Figure 2 As shown, the magnetic separation device of this application further includes a drive assembly 600, which can be disposed on the base 100. The output end of the drive assembly 600 is connected to the carrier 220, so that the drive assembly 600 can drive the carrier 220 to rotate. Specifically, the drive assembly 600 may include a first driver 610 and a transmission component 620. The first driver 610 may be a motor and may be fixed on the base 100. The transmission component 620 may be connected to the first driver 610 and the carrier 220, and the transmission component 620 may adopt a pulley structure. Specifically, the carrier 220 may be provided with a connecting shaft 222, and both the output end of the first driver 610 and the connecting shaft 222 of the carrier 220 may be provided with pulleys, and the two pulleys are connected by belt drive. In addition, the transmission component 620 may also adopt a gear transmission structure. This application does not limit the specific structure of the transmission component 620.

[0062] The connecting shaft 222 of the carrier 220 can be disposed at the bottom of the carrier 220 and pass through the base 100 to one side of the bottom of the base 100. Correspondingly, the first driver 610 and the transmission member 620 can be disposed on one side of the bottom of the base 100. This avoids the drive assembly 600 occupying the space on the top side of the base 100, making it easier to set up the magnetic separation mechanism 200.

[0063] In some implementations, reference Figure 2 and Figure 3 As shown, the temperature control component of this application includes a heating element 410, which heats the magnetic separation mechanism 200. At least a portion of the structure of the heating element 410 is opposite to the magnetic separation mechanism 200; that is, at least a portion of the projection of the magnetic separation mechanism 200 onto the plane of the heating element 410 lies within the heating element 410. The plane of the heating element 410 refers to the plane containing the end face of the heating element 410 facing the magnetic separation mechanism 200. For example, in... Figure 3 In the illustrated embodiment, the heating element 410 is a plate-shaped structure located within the accommodating cavity at the bottom of the mounting base 210. The entire structure of the heating element 410 is positioned opposite to the bottom of the mounting base 210, and the plane containing the heating element 410 is the end face of the heating element 410 facing the bottom of the mounting base 210. It should be noted that the heating element 410 of this application can directly contact the magnetic separation mechanism 200 or be spaced apart from it, as long as at least a portion of the structure of the heating element 410 is positioned opposite to the magnetic separation mechanism 200 and can heat the magnetic separation mechanism 200. By positioning at least a portion of the structure of the heating element 410 opposite to the magnetic separation mechanism 200, the heating effect of the heating element 410 can be improved.

[0064] Furthermore, in some embodiments, the heating element 410 may be configured to contact the mounting base 210 of the magnetic separation mechanism 200, so that the heating element 410 can directly heat the mounting base 210, thereby improving the heating effect of the heating element 410 on the mounting base 210 and the magnetic separation chamber 211 of the mounting base 210. Specifically, the heating element 410 may be disposed on the bottom side of the mounting base 210 and located between the base 100 and the mounting base 210, so as to improve the heating effect of the heating element 410 on the mounting base 210.

[0065] At least one support column 110 may be provided between the base 100 and the mounting base 210. One end of the support column 110 is connected to the base 100, and the other end is connected to the mounting base 210. The support column 110 creates a certain gap between the mounting base 210 and the base 100. The heating element 410 is disposed within the gap between the mounting base 210 and the base 100. The heating element 410 may abut against the bottom surface of the mounting base 210 or be spaced apart from the mounting base 210. In this embodiment, the heating element 410 is disposed at the bottom of the mounting base 210, which allows the mounting base 210 to be heated evenly. Multiple support columns 110 may be provided, and multiple support columns 110 may be evenly distributed on the base 100 so that multiple parts of the mounting base 210 can be supported.

[0066] In other embodiments, the heating element 410 may also be disposed on the side or top of the mounting base 210, so that the heating element 410 can also serve the purpose of heating the mounting base 210.

[0067] In some implementations, reference Figure 2As shown, the temperature control component of this application may also include a heat insulation element 420. The heat insulation element 420 may be arranged around the outer wall of the mounting base 210, so that the heat insulation element 420 can cover the mounting base 210. In this way, after the heating element 410 heats the mounting base 210, the heat insulation element 420 can reduce the heat dissipation of the mounting base 210 to a certain extent, so that the mounting base 210 can maintain the temperature. This results in a better heating effect on the sample in the magnetic separation chamber 211 of the mounting base 210. Specifically, the heat insulation element 420 includes a first heat insulation element 421 and / or a second heat insulation element 422. The first heat insulation element 421 is located on the circumferential sidewall of the mounting base 210, and the second heat insulation element 422 is located between the heating element 410 and the base 100.

[0068] The second insulation element 422 encloses the heating element 410, placing the heating element 410 between the second insulation element 422 and the bottom wall of the mounting base 210. This allows a greater portion of the heat generated by the heating element 410 to be stored within the insulation element 422, resulting in better heating of the mounting base 210. Furthermore, the insulation element 422 also prevents the heating element 410 from being exposed, thus preventing users from accidentally touching the heating element 410 and the mounting base 210 and suffering burns.

[0069] In addition, the insulation component 420 may also be provided with a third insulation component 423, which may be provided on the cover plate 240. The third insulation component 423 can prevent heat from dissipating from the cover plate 240 to a certain extent.

[0070] In some implementations, reference Figure 3 As shown, the temperature control component may also include a detection element 430 and a control element 440. The detection element 430 is disposed in the mounting base 210, specifically within the magnetic separation chamber 211 of the mounting base 210. The detection element 430 is a temperature sensor that monitors the temperature within the magnetic separation chamber 211 of the mounting base 210. The control element 440 is connected to both the detection element 430 and the heating element 410. The control element 440 controls the heating amount of the heating element 410 based on the temperature of the magnetic separation chamber 211 monitored by the detection element 430. Specifically, when the temperature within the magnetic separation chamber 211 is too high, the control element 440 controls the heating element 410 to reduce its heat output, so that the temperature within the magnetic separation chamber 211 reaches the target temperature required by the user; when the temperature within the magnetic separation chamber 211 is too low, the control element 440 controls the heating element 410 to increase its heat output, so that the temperature within the magnetic separation chamber 211 reaches the target temperature required by the user.

[0071] Furthermore, in some embodiments, the magnetic separation device of this application may also include an alarm element, which can be electrically connected to the control element 440. When the detection element 430 detects that the temperature of the mounting base 210 is too high or too low, the control element 440 can control the alarm element to issue an alarm prompt.

[0072] The magnetic separation device can also be equipped with a sensor for detecting whether the magnetic separation device is in a fault state. The sensor is connected to the control unit 440. When the sensor detects that the magnetic separation device is in a fault state, the heating element 410 can be turned off by the control unit 440, thereby protecting the magnetic separation device.

[0073] Furthermore, the temperature control component of this application can control not only the temperature of the magnetic separation mechanism 200, but also the temperature of the flow passage structure 300. That is, this application can simultaneously control the temperature of the magnetic separation mechanism 200 and the flow passage structure 300 with only one temperature control component, thus eliminating the need to set up separate heating mechanisms for the magnetic separation mechanism 200 and the flow passage structure 300. This simplifies the structure of the magnetic separation device, making it more compact and cost-effective.

[0074] It should be noted that this application does not limit the layout of the temperature control component, the magnetic separation mechanism 200, and the flow passage structure 300, as long as the temperature control component can simultaneously control the temperature of the magnetic separation mechanism 200 and the flow passage structure 300. For example, in some embodiments, the flow passage structure 300 and the magnetic separation mechanism 200 can be spaced apart on the base 100, and the flow passage structure 300 and the magnetic separation mechanism 200 respectively abut against the heating element 410, and the heating element 410 simultaneously heats the magnetic separation mechanism 200 and the flow passage structure 300. Specifically, the heating element 410 can be located between the flow passage structure 300 and the magnetic separation mechanism 200, with the flow passage structure 300 and the magnetic separation mechanism 200 abutting against opposite sides of the heating element 410; or, the flow passage structure 300 and the magnetic separation mechanism 200 can be located on the same side of the heating element 410, and both abut against the heating element 410. In other embodiments, the magnetic separation mechanism 200 may abut against the heating element 410, and the flow passage structure 300 may be disposed on the magnetic separation mechanism 200.

[0075] In some implementations, reference Figure 1 , Figure 4 and Figure 7As shown, the flow path structure 300 may include a delivery pipe 310 and a liquid injection component 320, with the liquid injection component 320 connected to the delivery pipe 310. Specifically, the delivery pipe 310 has an inlet end and an outlet end. The inlet end of the delivery pipe 310 can be connected to a container filled with cleaning fluid, so that the cleaning fluid can be pumped into the delivery pipe 310. The outlet end of the delivery pipe 310 is connected to the liquid injection component 320, and the outlet end of the liquid injection component 320 can face into the magnetic separation chamber 211 of the mounting base 210. The carrier 220 can be rotated so that the reaction cup bearing position 221 is opposite to the outlet end of the liquid injection component 320, so that the liquid injection component 320 can inject the cleaning fluid into the reaction cup 500 of the reaction cup bearing position 221.

[0076] The injection component 320 can be fixed on the mounting base 210, and the delivery pipe 310 can be detachably connected to the injection component 320. This allows the delivery pipe 310 to be separated from the injection component 320 when the magnetic separation device is not in use. In case of damage to the delivery pipe 310, it can be replaced separately, thereby reducing the maintenance cost of the magnetic separation device of this application. Specifically, the injection component 320 can be installed through the cover plate 240, allowing one end of the injection component 320 to extend into the magnetic separation chamber 211 of the mounting base 210, while the other end of the injection component 320 can remain outside the magnetic separation chamber 211, facilitating the user's installation and connection of the delivery pipe 310 and the injection component 320.

[0077] In some embodiments, the flow path structure 300 includes a delivery pipe 310 and a plurality of injection fittings 320. Specifically, the delivery pipe 310 has a plurality of outlet ends, and each outlet end of the delivery pipe 310 is connected to an injection fitting 321. The inlet end of the delivery pipe 310 is in communication with a container containing cleaning fluid, and the cleaning fluid can be pumped into the magnetic separation chamber 211 through the plurality of injection fittings 321 connected to the delivery pipe 310.

[0078] In some implementations, reference Figure 7 and Figure 8 As shown, the delivery pipe 310 may specifically include at least one heat-conducting pipe 311. The heat-conducting pipe 311 is disposed on the mounting base 210. When the temperature control component heats the mounting base 210, the heat from the mounting base 210 can be conducted to the heat-conducting pipe 311, thus heating the heat-conducting pipe 311 as well. The cleaning fluid can be heated as it passes through the heat-conducting pipe 311, achieving the purpose of heating the cleaning fluid. In this way, the temperature control component can heat the sample in the reaction cup 500 on the reaction cup support position 221, and also heat the cleaning fluid in the flow path structure 300, thereby reducing the number of components in the magnetic separation device, making the magnetic separation device more compact and lower in cost.

[0079] Multiple heat-conducting pipes 311 can be provided, and multiple heat-conducting pipes 311 can be installed on the mounting base 210, so that multiple heat-conducting pipes 311 can be heated by the mounting base 210. Multiple heat-conducting pipes 311 can be set independently or connected in sequence. When multiple heat-conducting pipes 311 are set independently, multiple liquid injection components 320 can also be provided. Multiple liquid injection components can be connected to the liquid outlet of multiple heat-conducting pipes 311 respectively, and the other end of multiple heat-conducting pipes 311 can be connected to a container containing cleaning fluid. The cleaning fluid can be pumped to multiple liquid injection components 320 through multiple heat-conducting pipes 311, and the liquid outlet of multiple liquid injection components 320 can be set to face into the magnetic separation chamber 211 of the mounting base 210. When the carrier 220 rotates, it can drive the reaction cup 500 to rotate to face the liquid outlet of multiple liquid injection components 320 respectively. In this way, cleaning fluid can be injected into the reaction cup 500 multiple times through multiple heat-conducting pipes 311 and multiple liquid injection components 320 to improve detection efficiency.

[0080] In some implementations, reference Figure 7 and Figure 8 As shown, the delivery pipe 310 may also include at least one connecting pipe 312. The connecting pipe 312 may be disposed between the heat-conducting pipe 311 and the liquid injection component 320. Specifically, one end of the connecting pipe 312 is connected to the liquid outlet end of the heat-conducting pipe 311, and the other end of the connecting pipe 312 is connected to the liquid injection component 320. The connecting pipe 312 may have a flexible structure, allowing it to be bent, thus facilitating the connection between the heat-conducting pipe 311 and the liquid injection component 320.

[0081] When there are multiple heat-conducting pipes 311, both ends of the connecting pipe 312 can be connected to two heat-conducting pipes 311 respectively. Specifically, one end of the connecting pipe 312 can be connected to the liquid outlet of one heat-conducting pipe 311, and the other end of the connecting pipe 312 can be connected to the liquid inlet of another heat-conducting pipe 311. The liquid outlet of the other heat-conducting pipe 311 can be connected to the injection device 320 through another connecting pipe 312. In this way, the two heat-conducting pipes 311 can be connected, and the cleaning solution can be injected into the reaction cup 500 through the two heat-conducting pipes 311 and then through the injection device 320, so that the cleaning solution has a longer path through the heat-conducting pipes 311, and thus the cleaning solution is heated more fully.

[0082] Furthermore, when a larger number of heat-conducting pipes 311 need to be connected, every two heat-conducting pipes 311 can be connected by a connecting pipe 312. This allows the number of connected heat-conducting pipes 311 to be selected according to actual needs, thereby controlling the heating level of the cleaning fluid. The more heat-conducting pipes 311 connected by the connecting pipe 312, the longer the heating path of the cleaning fluid within the delivery pipe 310, resulting in a higher temperature for the cleaning fluid. Conversely, the fewer heat-conducting pipes 311 connected by the connecting pipe 312, the relatively lower the temperature of the cleaning fluid. Therefore, the heating temperature of the cleaning fluid can be controlled by controlling the number of connected heat-conducting pipes 311.

[0083] In some implementations, reference Figure 7 and Figure 8 As shown, to ensure more adequate contact between the heat conduction pipe 311 and the mounting base 210, at least a portion of the heat conduction pipe 311 may be disposed within the mounting base 210. Specifically, a fixing groove 212 for accommodating at least a portion of the heat conduction pipe 311 may be provided within the mounting base 210. The heat conduction pipe 311 may be configured to include a main body portion 311a and at least one connector portion 311b connected to the main body portion 311a. The main body portion 311a may be disposed within the fixing groove 212 of the mounting base 210, which may be located within the side wall of the mounting base 210. Two connector portions 311b may be provided, communicating with both ends of the main body portion 311a. The two connector portions 311b may be located outside the mounting base 210. The connecting pipe 312 may be connected to the connector portions 311b. By disposing the connector portions 311b outside the mounting base 210, the connecting pipe 312 and the connector portions 311b can be easily assembled and disassembled. The inner wall of the fixing groove 212 can also be coated with a thermally conductive layer, which can be made of thermally conductive silicone grease. The main body 311a is in contact with the thermally conductive silicone grease, so that the temperature of the mounting base 210 can be conducted to the main body 311a more efficiently, thereby allowing the cleaning fluid passing through the thermally conductive pipe 311 to be heated more fully. The thermally conductive pipe 311 is detachably installed in the fixing groove 212, so that when the thermally conductive pipe 311 fails, it can be removed from the fixing groove 212, making the maintenance and repair of the magnetic separation device of this application convenient.

[0084] The main body 311a is bendably disposed within the mounting base 210, and correspondingly, the fixing groove 212 of the mounting base 210 can also be configured as a bendable groove structure. The bendable arrangement of the main body 311a increases the pipe length of the main body 311a, thereby increasing the pipe length of the heat-conducting pipe 311. When the cleaning fluid flows within the heat-conducting pipe 311, the longer the pipe length through which the cleaning fluid can pass, the longer the contact time between the cleaning fluid and the heat-conducting pipe 311 at a constant flow rate, allowing for more thorough heating of the cleaning fluid.

[0085] Specifically, the main body 311a can be configured as a U-shaped structure or a zigzag structure with multiple bends. This application does not limit the specific shape of the main body 311a.

[0086] It should be noted that this application does not limit the specific structure of the delivery pipe 310, as long as it is a flow passage structure. Although in the embodiment shown in the figure, the heat conduction pipe 311 is a U-shaped pipe detachably mounted on the mounting base 210, in other embodiments, the heating pipe 311 can also be a channel directly opened on the mounting base 210, which has at least one liquid outlet. The liquid injection component 320 can be directly or indirectly connected to the corresponding liquid outlet, and the cleaning fluid can be delivered directly through the channel on the mounting base 210.

[0087] In some embodiments, the main body 311a may also be disposed in the magnetic separation chamber 211. Since the heating element 410 can heat the magnetic separation chamber 211, the main body 311a located in the magnetic separation chamber 211 can also be heated, and correspondingly, the liquid flowing through the main body 311a can be heated.

[0088] In some embodiments, the heat conduction pipe 311 may also be disposed outside the mounting base 210 and not in contact with the mounting base 210. In this case, the heat conduction pipe 311 may be configured to directly contact or be disposed close to the heating element 410, so that the heat conduction pipe 311 can also be heated, thereby heating the liquid flowing through the heat conduction pipe 311. Alternatively, the heating element 410 may not be disposed on the mounting base 210, and the heating element 410 may be disposed at a distance from the mounting base 210, so that the heating element 410 can indirectly heat the mounting base 210.

[0089] Furthermore, in some implementations, references Figure 5 and Figure 6 As shown, a waste liquid cup holder 223 can also be provided on the carrier 220, which can be used to place the waste liquid cup 510. Before the magnetic separation operation begins, the waste liquid cup 510 placed in the waste liquid cup holder 223 can be rotated to the injection position via the carrier 220. An injection device 320 is provided above the injection position, and cleaning fluid is injected into the flow passage structure 300 to drain the liquid remaining in the flow passage structure 300 from the previous test into the waste liquid cup 510, thus cleaning the flow passage structure 300 and preventing residual waste liquid from affecting the current test results. After the residual waste liquid in the flow passage structure 300 is drained, the current magnetic separation operation can begin, so that residual waste liquid in the passage will not affect the current test results. This application, by providing a waste liquid cup holder 223 on the carrier 220, allows the flow passage structure 300 to be cleaned without disassembling it, and the cleaning process does not waste the reaction cups used for testing.

[0090] In some implementations, reference Figure 1 , Figure 2 and Figure 9 As shown, the magnetic separation device of this application preferably includes a lifting assembly 800 and a liquid suction component 700, wherein the liquid suction component 700 can draw the cleaning liquid from the reaction cup 500 placed on the reaction cup support position 221. It should be understood that when the cleaning liquid is injected into the reaction cup 500, and the sample in the reaction cup 500 is separated by magnetic adsorption by the magnetic component 230, the cleaning liquid becomes waste liquid, and the liquid suction component 700 can draw the waste liquid from the reaction cup 500.

[0091] Specifically, a suction port 242 can be provided on the cover plate 240, which is opposite to the suction end 710 of the suction member 700. The lifting assembly 800 can be disposed on the base 100, and the suction member 700 is connected to the lifting assembly 800. The lifting assembly 800 can drive the suction member 700 to rise and fall, so that the height of the suction end 710 of the suction member 700 is adjustable. The rotation of the support member 220 can make the opening of the reaction cup 500 placed on the support member 220 opposite to the suction port 242 of the cover plate 240. The lifting assembly 800 can drive the height of the suction member 700 to fall, so that the suction end 710 of the suction member 700 can pass through the suction port 242 of the cover plate 240 and extend into the magnetic separation chamber 211 of the mounting base 210, and then into the reaction cup 500. After the suction member 700 draws the waste liquid from the reaction cup 500, the lifting assembly 800 can drive the suction member 700 to rise, allowing it to move outside the magnetic separation chamber 211 of the mounting base 210. This prevents the suction member 700 from interfering with the reaction cup 500, and the rotation of the support member 220 can continue to rotate the reaction cup 500. Furthermore, when multiple reaction cups 500 are placed on the support member 220, the rotation of the support member 220 can also rotate other reaction cups 500 to face the suction port 242 of the cover plate 240. In this way, the lifting assembly 800 can again drive the suction member 700 to descend and extend into the reaction cup 500, allowing the suction member 700 to draw the liquid from the reaction cup 500.

[0092] Multiple suction components 700 can be provided, and correspondingly, multiple suction ports 242 on the cover plate 240 can also be provided. Multiple suction components 700 are connected to the lifting assembly 800, and multiple suction ports 242 are correspondingly arranged with multiple suction components 700, allowing multiple suction components 700 to extend into the magnetic separation chamber 211 of the mounting base 210 through multiple suction ports 242. Rotation of the carrier 220 can drive multiple reaction cups 500 to rotate so that they are aligned with their respective suction ports 242, and thus with the suction ends 710 of the multiple suction components 700. In this way, the lifting assembly 800 can drive multiple suction components 700 to sequentially extend into the reaction cups 500, allowing for multiple suctions of waste liquid from the reaction cups 500.

[0093] Specifically, the number of liquid injection components 320 in this application is multiple, and some of the liquid injection components 320 can be arranged adjacent to the liquid suction port 242 of the cover plate 240, so that each liquid suction port 242 has an adjacent liquid injection component 320 on one side. The multiple liquid injection components 320 can specifically include a first liquid injection component 320a, a second liquid injection component 320b, a third liquid injection component 320c, and a fourth liquid injection component 320d. The first liquid injection component 320a, the second liquid injection component 320b, the third liquid injection component 320c, and the fourth liquid injection component 320d are distributed along the rotation direction of the support component 220. The second liquid injection component 320b, the third liquid injection component 320c, and the fourth liquid injection component 320d are all adjacent to the liquid suction port 242 on one side. Specifically, when the reaction cup 500 is opposite any of the suction ports 242, the openings of the second injection component 320b, the third injection component 320c, or the fourth injection component 320d also face the reaction cup 500, allowing the second injection component 320b, the third injection component 320c, or the fourth injection component 320d to inject cleaning fluid into the reaction cup 500. This allows cleaning fluid to be directly injected into the reaction cup 500 after it has been drawn from it, reducing the number of start-stop cycles required for the drive assembly 600 to drive the carrier component 220 to rotate.

[0094] The rotation of the carrier 220 causes the reaction cup 500 to sequentially approach multiple suction components 700, specifically including a first suction component 700a, a second suction component 700b, and a third suction component 700c. When the carrier 220 moves the reaction cup 500 to be opposite the first injection component 320a, the first injection component 320a can inject cleaning fluid into the reaction cup 500. Subsequently, the rotation of the carrier 220 causes the reaction cup 500 to move to be opposite the first suction component 700a, and the lifting assembly 800 drives the first suction component 700a to extend into the reaction cup 500. The first suction component 700a can draw the cleaning fluid from the reaction cup 500 of the carrier 220, and then the second injection component 320b can inject cleaning fluid into the reaction cup 500 again. The carrier 220 continues to rotate, driving the reaction cup 500 to rotate until it is opposite to the second suction member 700b. The lifting assembly 800 drives the second suction member 700b to extend into the reaction cup 500, whereby the second suction member 700b can draw the cleaning fluid from the reaction cup 500 of the carrier 220. Then, the third injection member 320c can inject cleaning fluid back into the reaction cup 500. The carrier 220 continues to rotate, driving the reaction cup 500 to rotate until it is opposite to the third suction member 700c. The lifting assembly 800 drives the third suction member 700c to extend into the reaction cup 500, whereby the third suction member 700c can draw the cleaning fluid from the reaction cup 500 of the carrier 220. Then, the fourth injection member 320d can inject cleaning fluid back into the reaction cup 500. Subsequently, the lifting assembly 800 again drives the third suction member 700c to extend into the reaction cup 500 to completely draw out the cleaning fluid from the reaction cup 500.

[0095] During this process, the reaction cup 500 can pass through multiple magnetic components 230 in sequence. The multiple magnetic components 230 can magnetically adsorb the sample in the reaction cup 500 to extract the target analyte from the sample.

[0096] The cover plate 240 may also have a pick-and-place port 241 and an activation liquid port 244. After the activation liquid is injected, the carrier 220 can rotate the reaction cup 500 to face the pick-and-place port 241 on the cover plate 240, so that the reaction cup 500 can be removed from the carrier 220. Correspondingly, the reaction cup 500 can also be placed on the reaction cup support position 221 of the carrier 220 through the pick-and-place port 241. When the carrier 220 rotates to face the activation liquid port 244, the preheated activation liquid can be injected into the reaction cup 500 through the activation liquid port 244.

[0097] In some implementations, reference Figure 1 and Figure 9 As shown, the lifting assembly 800 of this application may specifically include a second driver 810, a mounting plate 820, and guide rods 830. Multiple guide rods 830 may be provided, and these guide rods 830 are vertically mounted on the base 100. Multiple openings may be provided on the mounting plate 820 for the guide rods 830 to pass through. The second driver 810 may be disposed on the mounting plate 820 and cooperate with the guide rods 830, and the second driver 810 may drive the mounting plate 820 to move axially along the guide rods 830. Multiple liquid suction elements 700 may be disposed on the mounting plate 820.

[0098] Specifically, the guide rod 830 can be positioned at the edge of the base 100, and the cover plate 240 has a fixing hole 243 for the guide rod 830 to pass through. One end of the guide rod 830 passes through the fixing hole 243 of the cover plate 240 and is fixed to the base 100. The guide rod 830 can adopt a screw structure, and the second actuator 810 can be provided with a nut that cooperates with the screw structure. The rotation of the second actuator 810 can cause the second actuator 810 itself to move axially along the guide rod 830, thereby allowing the mounting plate 820 and the liquid suction member 700 disposed on the mounting plate 820 to move axially along the guide rod 830.

[0099] Based on the magnetic separation device described above, this application also proposes a sample analyzer that includes the magnetic separation device described above.

[0100] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A magnetic separation device, characterized in that, The device includes a base, and a magnetic separation mechanism, a flow passage structure, and a temperature control component disposed on the base. The flow passage structure is configured to inject liquid into the magnetic separation mechanism, and the temperature control component controls the temperature of the magnetic separation mechanism and the flow passage structure. The temperature control component includes a heating element, at least a portion of which is opposite to the magnetic separation mechanism. The magnetic separation mechanism includes a mounting base and a magnetic separation component. The mounting base is provided with a magnetic separation chamber, and the magnetic separation component is located inside the magnetic separation chamber. Both the heating element and the flow passage structure are mounted on the mounting base; The flow path structure includes a delivery pipe and a liquid injection device, wherein the liquid injection device is connected to the liquid outlet end of the delivery pipe; The delivery pipeline includes at least one heat-conducting pipe, which is disposed on the mounting base.

2. The magnetic separation device according to claim 1, characterized in that, The flow passage structure and the magnetic separation mechanism are respectively abutted to the heating element; or, the magnetic separation mechanism abuts to the heating element, and the flow passage structure is disposed on the magnetic separation mechanism.

3. The magnetic separation device according to claim 1, characterized in that, The heating element is disposed on the bottom wall of the mounting base, and the flow passage structure is disposed on the side wall of the mounting base.

4. The magnetic separation device according to claim 1, characterized in that, The temperature control component also includes a heat insulation element disposed on the outer wall of the mounting base, and the heating element is located between the heat insulation element and the mounting base.

5. The magnetic separation device according to claim 1, characterized in that, The temperature control component further includes a detection element and a control element. The heating element and the detection element are respectively connected to the control element. The control element controls the switching on and off of the heating element and / or the heating temperature of the heating element according to the detection result of the detection element.

6. The magnetic separation device according to claim 1, characterized in that, The delivery pipeline further includes at least one connecting pipeline, which connects the liquid outlet of the heat-conducting pipeline to the liquid injection component; and / or, the connecting pipeline connects between two heat-conducting pipelines, thereby enabling the two heat-conducting pipelines to conduct.

7. The magnetic separation device according to claim 6, characterized in that, The heat-conducting pipe includes a main body and at least one connector communicating with the main body. At least a portion of the main body is disposed on the mounting base, and the connector extends outside the mounting base and is connected to the connecting pipe.

8. The magnetic separation device according to claim 1, characterized in that, The mounting base has a fixing groove on its side wall, and the heat conduction pipe is detachably connected to the fixing groove.

9. The magnetic separation device according to claim 8, characterized in that, The inner wall of the fixing groove is provided with a heat-conducting layer.

10. The magnetic separation device according to claim 1, characterized in that, The magnetic separation mechanism also includes a cover plate, which is detachably connected to the opening of the magnetic separation chamber. The liquid injection component is disposed on the cover plate and extends into the magnetic separation chamber.

11. A sample analyzer, characterized in that, Includes the magnetic separation device as described in any one of claims 1-10.

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