2-Indolyl-3-imineindoline derivatives, their preparation methods and applications
The synthesis of 2-indolyl-3-imineindolline derivatives via a multi-component one-pot reaction solves the problem of the lack of such compounds in the existing technology, achieving high yield and antitumor activity, and is suitable for the preparation of antitumor drugs.
CN117886736BActive Publication Date: 2026-05-26SUZHOU HIGHFINE BIOTECH +1
Patent Information
- Authority / Receiving Office
- CN Β· China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUZHOU HIGHFINE BIOTECH
- Filing Date
- 2023-12-14
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing technologies have not yet developed compounds with 2-indolyl-3-imine-indoline as the molecular skeleton, and there is a lack of compounds with antitumor activity.
Method used
2-Indolyl-3-imineindoline derivatives were synthesized via a multi-component one-pot reaction using phenylboronic acid, isonitriles, and indole as raw materials in the presence of metal salt catalysts and solvents. The reaction conditions were mild, the substrate range was wide, and the functional group compatibility was good.
Benefits of technology
The preparation method is simple, with a yield of up to 98%, making it suitable for industrial mass production, and it exhibits good anti-tumor activity.
β¦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN117886736B_ABST
Abstract
This invention discloses a 2-indolyl-3-imineindoline derivative, its preparation method, and its application. The structure of the 2-indolyl-3-imineindoline derivative is shown below: wherein, R 1 Selected from one of H, halogen, cyano, C1-C4 alkyl, C1-C4 alkoxy, C5-C10 aryl, R 2 Selected from one of hydrogen, halogen, C1-C4 alkoxy, and C1-C4 alkyl, R 3 Selected from one of hydrogen, halogen, C1-C4 alkoxy, and C1-C4 alkyl, R 4 The derivatives are selected from hydrogen, C1-C4 alkyl groups, and substituted or unsubstituted phenyl groups. These 2-indolyl-3-imine indoline derivatives can be constructed in one step using simple starting materials. The preparation method is simple, has a wide range of applicable substrates, and good functional group compatibility. Furthermore, these 2-indolyl-3-imine indoline derivatives possess tumor-suppressive activity and show promising application prospects in the preparation of antitumor drugs.
Need to check novelty before this filing date? Find Prior Art