A traditional Chinese medicine composition for improving heart-kidney disharmony insomnia, a preparation method of a capsule thereof and an application thereof

Abstract

The application discloses a traditional Chinese medicine composition for improving heart-kidney incoordination type insomnia and a preparation method and application of a capsule of the traditional Chinese medicine composition. The traditional Chinese medicine composition is composed of the following raw medicinal materials: eucommia ulmoides, acanthopanax bark, spina date, albizia flower, radix bupleuri, gastrodia elata, polygala, and ligusticum chuanxiong. The application further discloses a preparation method of a capsule preparation of the traditional Chinese medicine composition for improving heart-kidney incoordination type insomnia. The traditional Chinese medicine composition provided by the application is mainly composed of traditional Chinese medicinal materials with the same effect on food and medicine, has the effects of tonifying liver and kidney, nourishing heart and calming mind, and soothing liver and relieving depression, and can effectively improve heart-kidney incoordination type insomnia.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony, and its preparation method and application in capsule form. Background Technology

[0002] With rapid social and economic development, insomnia has become a common clinical condition, characterized by difficulty falling asleep, reduced sleep duration, decreased sleep quality, frequent awakenings, early awakenings, and difficulty falling back asleep. According to the "2022 China National Health Sleep White Paper," nearly 75% of 9,082 respondents in my country had experienced sleep problems, with difficulty falling asleep, insomnia, and frequent awakenings being the main issues. Among them, 42% of elderly people take more than half an hour to fall asleep, and the insomnia rate is as high as 21%. Long-term insomnia will seriously affect the physical and mental health of patients, and even impact their normal work and life.

[0003] Modern medicine primarily treats insomnia through psychotherapy, physical therapy, and medication. Among these, benzodiazepines are commonly used. Receptor agonists, such as triazolam, estazolam, and temazepam, although they have a rapid onset of action, pose potential risks such as adverse reactions, addiction, and withdrawal symptoms.

[0004] Traditional Chinese medicine (TCM) employs a syndrome differentiation and treatment approach, typically classifying insomnia into four types: heart-liver fire excess, spleen-stomach disharmony, grief-induced lung injury, heart-kidney disharmony, and qi and blood deficiency. TCM offers a variety of treatments for insomnia, including herbal medicine, acupuncture, and massage. It employs methods that address excess by purging and deficiency by tonifying, and these approaches are widely used clinically with good therapeutic effects. Currently, the commonly used TCM formulas for improving insomnia, such as Suanzaoren Tang (Ziziphus jujuba seed decoction), primarily treat qi deficiency insomnia; and Tianwang Buxin Dan (Heavenly King Heart-Nourishing Pill), primarily treat yin deficiency insomnia. Therefore, the advantages of TCM in treating insomnia deserve further exploration and development. Summary of the Invention

[0005] This invention provides a traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony, a method for preparing its capsule formulation, and its application, thereby developing a low-cost and effective drug for improving insomnia.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0007] This invention provides a traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony. The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 20-40 parts of Eucommia ulmoides, 20-40 parts of Acanthopanax senticosus, 10-30 parts of Ziziphus jujuba var. spinosa, 10-30 parts of Albizia julibrissin, 10-30 parts of Bupleurum chinense, 10-30 parts of Gastrodia elata, 10-30 parts of Polygala tenuifolia, and 5-25 parts of Ligusticum chuanxiong.

[0008] As a preferred embodiment of the present invention, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 25-35 parts of Eucommia ulmoides, 25-35 parts of Acanthopanax senticosus, 15-25 parts of Ziziphus jujuba var. spinosa, 15-25 parts of Albizia julibrissin, 15-25 parts of Bupleurum chinense, 15-25 parts of Gastrodia elata, 15-25 parts of Polygala tenuifolia, and 10-20 parts of Ligusticum chuanxiong.

[0009] As a more preferred embodiment of the present invention, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 30 parts of Eucommia ulmoides, 30 parts of Acanthopanax senticosus, 20 parts of Ziziphus jujuba var. spinosa, 20 parts of Albizia julibrissin, 20 parts of Bupleurum chinense, 20 parts of Gastrodia elata, 20 parts of Polygala tenuifolia, and 15 parts of Ligusticum chuanxiong.

[0010] This invention also provides a method for preparing a capsule of traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony, comprising the following steps:

[0011] (1) Purchase Chinese medicinal herbs, and take Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia and Ligusticum chuanxiong according to the above proportions by weight. Add 8 to 12 times the weight of the herbs in water. After soaking, simmer the soaking liquid and Chinese medicinal herbs over a low flame, and filter to obtain decoction 1.

[0012] (2) Add 8 to 12 times the weight of the medicinal materials to the remaining Chinese medicinal materials after extracting the decoction liquid 1 in step (1), simmer over low heat, and filter to obtain decoction liquid 2.

[0013] (3) Combine decoction 1 and decoction 2, heat and concentrate to obtain extract;

[0014] (4) The extract obtained in step (3) is dried, made into powder, and filled into empty capsules to make Chinese medicine capsules.

[0015] Preferably, in step (1), the ingredients are soaked before simmering over a low flame for 12 hours.

[0016] Preferably, the simmering time in steps (1) and (2) is 1.5 hours.

[0017] Preferably, the drying method in step (4) is freeze drying.

[0018] The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the preparation of a drug for improving insomnia caused by heart-kidney disharmony.

[0019] In this invention, preferred dosage forms of the drug also include granules and oral liquids.

[0020] The advantages of this invention are:

[0021] (1) The traditional Chinese medicine formula of this invention utilizes traditional Chinese medicine theory to target insomnia caused by heart-kidney disharmony. Based on the theory and practice of insomnia in traditional Chinese medicine, a formula containing Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia, and Ligusticum chuanxiong has been successfully prepared. The formula is simple and reasonable, with significant efficacy, convenient material sourcing and preparation, and easy to promote. Eucommia ulmoides in this formula enters the liver and kidney meridians and has the effects of tonifying the liver and kidneys, replenishing the middle energizer and replenishing essence and qi, strengthening will, strengthening tendons and bones, and calming the fetus. It is mainly used to treat lower back pain, seminal emission, and general weakness. Acanthopanax senticosus enters the liver and kidney meridians and has the effects of dispelling wind and dampness, tonifying the liver and kidneys, strengthening tendons and bones, and promoting diuresis and reducing swelling. Ziziphus jujuba var. spinosa enters the liver, gallbladder, and heart meridians and has the effects of nourishing the heart and liver, calming the mind and soothing the nerves, astringing sweat, and promoting body fluids. It is mainly used to treat insomnia due to deficiency and restlessness, palpitations and excessive dreaming, weakness and excessive sweating, and thirst due to fluid depletion. Albizia julibrissin flowers enter the Heart and Spleen meridians, possessing the effects of relieving depression, calming the mind, promoting blood circulation, and reducing swelling. They are often used to treat insomnia and blurred vision. Bupleurum chinense enters the Liver and Gallbladder meridians, possessing the effects of harmonizing the exterior and interior, soothing the liver, and raising Yang. Gastrodia elata enters the Liver meridian, possessing the effects of calming Liver Yang, dispelling wind, and unblocking the meridians. Polygala tenuifolia enters the Heart, Kidney, and Lung meridians, and can calm the mind, improve intelligence, and relieve depression. Ligusticum chuanxiong enters the Liver meridian, promoting Qi circulation, relieving depression, promoting blood circulation, and relieving pain. In this formula, Eucommia ulmoides and Acanthopanax senticosus are the principal herbs, which can tonify the Liver and Kidneys. Ziziphus jujuba var. spinosa and Albizia julibrissin flowers are the assistant herbs, which can nourish the Heart and calm the mind. Bupleurum chinense, Gastrodia elata, Polygala tenuifolia, and Ligusticum chuanxiong are the adjuvant herbs, exerting the effects of promoting Qi circulation, relieving depression, calming the mind, and improving intelligence.

[0022] (2) The traditional Chinese medicine composition provided by the present invention is mostly made of medicinal and edible herbs, which have the effects of nourishing the liver and kidneys, calming the mind and soothing the liver and relieving depression, and can effectively improve insomnia caused by heart-kidney disharmony.

[0023] (3) The present invention uses capsule formulation, which can effectively alleviate the difficulty of taking the medicine caused by the patient’s discomfort with the smell.

[0024] (4) This invention uses p-chlorophenylalanine-induced insomnia mice as an experimental model to explore the effect of traditional Chinese medicine composition on improving the sleep of insomnia mice. The results show that treatment with traditional Chinese medicine composition can improve the sleep rate of insomnia mice, significantly shorten the sleep latency of insomnia mice, and significantly prolong the sleep time of insomnia mice. Detailed Implementation

[0025] The present invention will be described in detail below with reference to specific embodiments.

[0026] To make the objectives, technical solutions, and advantages of this invention clearer, the following detailed embodiments further illustrate the preparation and application of the traditional Chinese medicine composition for improving insomnia due to heart-kidney disharmony and its capsule formulation. The following description is for illustrative purposes only and does not constitute a limitation thereof.

[0027] Example 1

[0028] A traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony includes the following components: Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia, and Ligusticum chuanxiong.

[0029] In this embodiment, the content of each component in the traditional Chinese medicine composition for improving insomnia due to heart-kidney disharmony is as follows, by weight: 30 parts of Eucommia ulmoides, 30 parts of Acanthopanax senticosus, 20 parts of Ziziphus jujuba var. spinosa, 20 parts of Albizia julibrissin, 20 parts of Bupleurum chinense, 20 parts of Gastrodia elata, 20 parts of Polygala tenuifolia, and 15 parts of Ligusticum chuanxiong.

[0030] (1) Purchase Chinese medicinal herbs, and take Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia and Ligusticum chuanxiong according to the above proportions by weight. Add 8 to 12 times the weight of the herbs to water and soak for 12 hours. After soaking, simmer the soaking liquid and Chinese medicinal herbs over low heat for 1.5 hours and filter to obtain 1 decoction.

[0031] (2) Add 8 to 12 times the weight of the medicinal materials to the remaining Chinese herbal medicine pieces after filtration of decoction liquid 1 in step (1), simmer for 1.5 hours, and filter to obtain decoction liquid 2.

[0032] (3) Combine decoction 1 and decoction 2, heat and concentrate to obtain extract;

[0033] (4) Freeze-dry the extract obtained in step (3) to make powder, fill it into empty capsules, and make Chinese medicine capsules.

[0034] Example 2

[0035] A traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony includes the following components: Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia, and Ligusticum chuanxiong.

[0036] In this embodiment, the content of each component in the traditional Chinese medicine composition for improving insomnia due to heart-kidney disharmony is as follows, by weight: 20 parts of Eucommia ulmoides, 20 parts of Acanthopanax senticosus, 10 parts of Ziziphus jujuba var. spinosa, 10 parts of Albizia julibrissin, 10 parts of Bupleurum chinense, 10 parts of Gastrodia elata, 10 parts of Polygala tenuifolia, and 5 parts of Ligusticum chuanxiong.

[0037] (1) Purchase Chinese medicinal herbs, and take Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia and Ligusticum chuanxiong according to the above proportions by weight. Add 8 to 12 times the weight of the herbs to water and soak for 12 hours. After soaking, simmer the soaking liquid and Chinese medicinal herbs over low heat for 1.5 hours and filter to obtain 1 decoction.

[0038] (2) Add 8 to 12 times the weight of the medicinal materials to the remaining Chinese herbal medicine pieces after filtration of decoction liquid 1 in step (1), simmer for 1.5 hours, and filter to obtain decoction liquid 2.

[0039] (3) Combine decoction 1 and decoction 2, heat and concentrate to obtain extract;

[0040] (4) Freeze-dry the extract obtained in step (3) to make powder, fill it into empty capsules, and make Chinese medicine capsules.

[0041] Example 3

[0042] A traditional Chinese medicine composition for improving insomnia caused by heart-kidney disharmony includes the following components: Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia, and Ligusticum chuanxiong.

[0043] In this embodiment, the components of the traditional Chinese medicine composition for improving insomnia due to heart-kidney disharmony are as follows, by weight: 40 parts of Eucommia ulmoides, 40 parts of Acanthopanax senticosus, 30 parts of Ziziphus jujuba var. spinosa, 30 parts of Albizia julibrissin, 30 parts of Bupleurum chinense, 30 parts of Gastrodia elata, 30 parts of Polygala tenuifolia, and 25 parts of Ligusticum chuanxiong.

[0044] (1) Purchase Chinese medicinal herbs, and take Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia and Ligusticum chuanxiong according to the above proportions by weight. Add 8 to 12 times the weight of the herbs to water and soak for 12 hours. After soaking, simmer the soaking liquid and Chinese medicinal herbs over low heat for 1.5 hours and filter to obtain 1 decoction.

[0045] (2) Add 8 to 12 times the weight of the medicinal materials to the remaining Chinese herbal medicine pieces after filtration of decoction liquid 1 in step (1), simmer for 1.5 hours, and filter to obtain decoction liquid 2.

[0046] (3) Combine decoction 1 and decoction 2, heat and concentrate to obtain extract;

[0047] (4) Freeze-dry the extract obtained in step (3) to make powder, fill it into empty capsules, and make Chinese medicine capsules.

[0048] Test case

[0049] I. Experimental Methods

[0050] 1. Main instruments and materials: analytical balance, beaker, syringe, timer, gavage needle, syringe, p-chlorophenylalanine (PCPA), sodium pentobarbital, physiological saline, the traditional Chinese medicine compositions prepared in Examples 1, 2 and 3 of this invention, and estazolam.

[0051] 2. Preparation of Insomnia Animal Model and Experimental Grouping: Forty-eight four-week-old male ICR mice were randomly divided into six groups of eight mice each after one week of acclimatization: normal control group, insomnia model group, traditional Chinese medicine composition group (I) (Example 1), traditional Chinese medicine composition group (II) (Example 2), traditional Chinese medicine composition group (III) (Example 3), and estazolam group. Except for the normal control group, the mice in the other groups were intraperitoneally injected with 450 mg / kg of p-chlorophenylalanine suspension daily for two consecutive days. The normal control group was intraperitoneally injected with an equal volume of physiological saline. 24–48 hours after the first intraperitoneal injection of PCPA, the mice in the normal control group had normal sleep, mental state, and appetite; the mice in the insomnia model group showed increased activity, increased aggression, multiple obvious wounds, and weight loss, which were significantly different from the normal control group. After modeling, mice in the normal control group and the insomnia model group were administered 1 mL / 100 g of physiological saline by gavage once daily. Mice in the traditional Chinese medicine composition group (I) were administered 1 mL / 100 g of the traditional Chinese medicine composition solution prepared in Example 1 of this invention (the traditional Chinese medicine composition powder was dissolved in distilled water to prepare a solution of 400 mg / mL) by gavage once daily. Mice in the traditional Chinese medicine composition group (II) were administered 1 mL / 100 g of the traditional Chinese medicine composition solution prepared in Example 2 of this invention by gavage once daily. Mice in the traditional Chinese medicine composition group (III) were administered 1 mL / 100 g of the traditional Chinese medicine composition solution prepared in Example 3 of this invention by gavage once daily. Mice in the estazolam group were administered 1 mL / 100 g of estazolam solution (estazolam powder was dissolved in distilled water to prepare a solution of 100 μg / mL) by gavage once daily. The gavage was continued for 5 consecutive days according to the above methods.

[0052] 3. Determination of the sleep-inducing rate of sodium pentobarbital: One hour after the last administration, mice in each group were intraperitoneally injected with 50 mg / kg of sodium pentobarbital, and the sleep-inducing status of the mice in each group was observed. The mice were placed belly-up; if they remained belly-up for 60 seconds without turning over, their righting reflex was considered to have disappeared. When the righting reflex disappeared and remained absent for more than 10 minutes, the mice were considered to have successfully fallen asleep.

[0053] 4. Determination of the sleep latency induced by sodium pentobarbital: One hour after the last administration, mice in each group were intraperitoneally injected with 50 mg / kg of sodium pentobarbital. The time it took for the righting reflex to disappear was observed. The time from the completion of intraperitoneal injection to the disappearance of the righting reflex was considered the sleep latency.

[0054] 5. Determination of the sleep-inducing time of sodium pentobarbital: One hour after the last administration, mice in each group were intraperitoneally injected with 50 mg / kg of sodium pentobarbital. The time for the recovery of the righting reflex was observed. The righting reflex was considered to have recovered when the mouse began to turn its body and could not maintain its abdomen facing upward within 30 seconds. The time period from the disappearance of the righting reflex to its recovery was considered the sleep time.

[0055] 6. Data Statistics and Analysis: SPSS 26.0 statistical software was used for analysis and processing. Quantitative data are expressed as mean ± standard deviation (x ± s). One-way ANOVA was used to test the significance of multiple groups, and the least significant difference (LSD) method was used for comparisons between groups. P < 0.05 was considered statistically significant.

[0056] II. Test Results

[0057] 1. A traditional Chinese medicine composition improves the sleep rate in insomnia-stricken mice.

[0058] As shown in Table 1, the sleep onset rate of mice in the insomnia model group induced by sodium pentobarbital was 62.5%, lower than the 100% sleep onset rate of mice in the normal control group. This indicates that the sleep onset of mice in the insomnia model group was worse, and the insomnia model was successfully established. The sleep onset rate of mice in each of the traditional Chinese medicine composition groups and the estazolam group all reached 100%, which means that the treatment with the traditional Chinese medicine compositions improved the sleep onset of insomnia mice.

[0059] Table 1. Sleep induction in mice of different groups induced by sodium pentobarbital

[0060] Group Number of babies falling asleep (babies) Sleep onset rate (%) normal control group 8 100 Insomnia model group 5 62.5 Traditional Chinese Medicine Composition Group (I) 8 100 Traditional Chinese Medicine Composition Group (II) 8 100 Traditional Chinese Medicine Composition Group (III) 8 100 estazolam group 8 100

[0061] 2. Traditional Chinese medicine composition shortens sleep latency in insomnia mice.

[0062] As shown in Table 2, in the pentobarbital sodium-induced sleep experiment in mice, the sleep latency of the normal control group was 4.17±0.69 minutes, and the sleep latency of the insomnia model group was 5.41±0.75 minutes, with a significant difference between the two (P<0.05). The sleep latency of the mice in the insomnia model group was significantly prolonged, indicating that the insomnia model was successfully established. The sleep latency of mice in the traditional Chinese medicine composition group (I) was 4.11±0.68 minutes; the sleep latency of mice in the traditional Chinese medicine composition group (II) was 4.26±0.54 minutes; and the sleep latency of mice in the traditional Chinese medicine composition group (III) was 4.04±0.56 minutes. All traditional Chinese medicine composition groups showed significant differences compared with the insomnia model group (P<0.05), indicating that the traditional Chinese medicine composition can effectively shorten the sleep latency of insomnia mice. The sleep latency of mice in the estazolam group was 3.95±0.43 minutes, which was not different from that of mice in the various traditional Chinese medicine composition groups. This indicates that the traditional Chinese medicine composition and estazolam have the same therapeutic effect in shortening the sleep latency of mice.

[0063] Table 2 Sleep latency of mice in each group

[0064] Group Sleep latency (minutes) normal control group <![CDATA[4.17±0.69 ＊ ]]> Insomnia model group 5.41±0.75 Traditional Chinese Medicine Composition Group (I) <![CDATA[4.05±0.76 ＊ ]]> Traditional Chinese Medicine Composition Group (II) <![CDATA[4.26±0.54 ＊ ]]> Traditional Chinese Medicine Composition Group (III) <![CDATA[4.04±0.56 ＊ ]]> estazolam group <![CDATA[3.95±0.43 ＊ ]]>

[0065] (Note: *P<0.05 indicates a statistically significant difference compared to the insomnia model group.)

[0066] 3. Traditional Chinese medicine composition prolongs sleep time in insomnia mice

[0067] As shown in Table 3, in the pentobarbital sodium-induced sleep experiment in mice, the sleep time of the normal control group was 48.51±5.47 minutes, and the sleep time of the insomnia model group was 33.17±4.49 minutes, with a significant difference between the two (P<0.05). The sleep time of the mice in the insomnia model group was significantly shortened, and the insomnia model was successfully established. The sleep time of mice in the traditional Chinese medicine composition group (I) was 70.53±6.09 minutes; the sleep time of mice in the traditional Chinese medicine composition group (II) was 60.39±14.66 minutes; and the sleep time of mice in the traditional Chinese medicine composition group (III) was 62.49±15.61 minutes. Each traditional Chinese medicine composition group showed significant differences compared with the insomnia model group and the normal control group (P<0.05), indicating that the traditional Chinese medicine compositions can effectively prolong the sleep time of mice, especially the traditional Chinese medicine composition group (I). The sleep time of mice in the estazolam group was 70.73±6.36 minutes, which was not different from that of the other traditional Chinese medicine composition groups. This indicates that the traditional Chinese medicine composition and estazolam have the same effect on prolonging the sleep time of mice.

[0068] Table 3 Sleep time of mice in each group

[0069]

[0070]

[0071] (Note: *P<0.05 indicates a statistically significant difference compared to the normal control group; compared to the insomnia model group, # P < 0.05 indicates a statistically significant difference.

[0072] This invention uses p-chlorophenylalanine-induced insomnia mice as an experimental model to explore the effects of a traditional Chinese medicine composition on improving sleep in these mice. The results show that treatment with the traditional Chinese medicine composition effectively increases the sleep onset rate, significantly shortens the sleep latency, and significantly prolongs the sleep duration in insomnia mice. Furthermore, compared with estazolam, the effect of the traditional Chinese medicine composition in improving insomnia in mice is not significantly different. However, long-term use of estazolam can lead to dependence. This invention provides a new therapeutic approach and effective treatment method for insomnia caused by heart-kidney disharmony.

[0073] It should be understood that those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. The application of a traditional Chinese medicine composition for improving insomnia due to heart-kidney disharmony in the preparation of a drug for improving insomnia due to heart-kidney disharmony, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 20-40 parts of Eucommia ulmoides, 20-40 parts of Acanthopanax senticosus, 10-30 parts of Ziziphus jujuba var. spinosa, 10-30 parts of Albizia julibrissin, 10-30 parts of Bupleurum chinense, 10-30 parts of Gastrodia elata, 10-30 parts of Polygala tenuifolia, and 5-25 parts of Ligusticum chuanxiong.

2. The application according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 25-35 parts of Eucommia ulmoides, 25-35 parts of Acanthopanax senticosus, 15-25 parts of Ziziphus jujuba var. spinosa, 15-25 parts of Albizia julibrissin, 15-25 parts of Bupleurum chinense, 15-25 parts of Gastrodia elata, 15-25 parts of Polygala tenuifolia, and 10-20 parts of Ligusticum chuanxiong.

3. The application according to claim 2, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 30 parts Eucommia ulmoides, 30 parts Acanthopanax senticosus, 20 parts Ziziphus jujuba var. spinosa, 20 parts Albizia julibrissin, 20 parts Bupleurum chinense, 20 parts Gastrodia elata, 20 parts Polygala tenuifolia, and 15 parts Ligusticum chuanxiong.

4. The application according to claim 1, characterized in that, The drug dosage forms are granules and oral liquids.

5. The method for preparing capsule formulations from traditional Chinese medicine compositions according to any one of claims 1 to 3, characterized in that, Includes the following steps: (1) Take Eucommia ulmoides, Acanthopanax senticosus, Ziziphus jujuba var. spinosa, Albizia julibrissin, Bupleurum chinense, Gastrodia elata, Polygala tenuifolia and Ligusticum chuanxiong according to the proportion of mass, add water of 8 to 12 times the mass of the medicinal materials, after soaking, simmer the soaking liquid and Chinese medicinal slices over low heat, filter to obtain decoction 1; (2) Add 8 to 12 times the weight of the medicinal materials to the remaining Chinese medicinal materials after extracting the decoction liquid 1 in step (1), simmer over low heat, repeat this process 2 to 3 times, and filter to obtain decoction liquid 2. (3) Combine decoction 1 and decoction 2, heat and concentrate to obtain extract; (4) Dry the extract obtained in step (3), make it into powder, fill it into empty capsules, and make Chinese medicine capsules.

6. The preparation method according to claim 5, characterized in that, Step (1) Soak the ingredients in water before simmering for 12 hours.

7. The preparation method according to claim 5, characterized in that, Simmer over low heat for 1.5 hours.

8. The preparation method according to claim 5, characterized in that, In step (4), the drying method is freeze drying.

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