A compound preparation for preventing and treating poultry enteritis and diarrhea and a preparation method thereof

By combining a compound preparation of ingredients such as Schizonepeta tenuifolia with the noodle soup fermentation process, the problems of side effects of chemical drugs and low efficiency of traditional Chinese medicine in the existing technology have been solved, and effective prevention and treatment of poultry enteritis and diarrhea and improvement of intestinal health have been achieved.

CN118001324BActive Publication Date: 2025-10-10HENAN DIYIFANG BIOPHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202410259054.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-03-07
Publication Date
2025-10-10
Estimated Expiration
2044-03-07

AI Technical Summary

Technical Problem

Existing chemical drugs used to prevent and treat poultry enteritis and diarrhea have side effects, drug resistance, high prices and insignificant efficacy. In addition, existing Chinese medicine preparation methods are inefficient and difficult to effectively improve intestinal health.

Method used

A compound preparation containing ingredients such as Schizonepeta tenuifolia, Radix Isatidis, Andrographis paniculata, Zanthoxylum bungeanum, Artemisia annua, Herba Euphorbiae Ibis, Atractylodes lancea, oligoxylose, allicin, capsaicin, vitamin C, vitamin A, Bacillus licheniformis and Clostridium butyricum is prepared through noodle soup fermentation technology to enhance pharmacological activity and promote intestinal health.

Benefits of technology

It improves the body's immune function, effectively prevents and treats poultry enteritis and diarrhea, improves intestinal health, enhances bioavailability, is suitable for group administration, and saves manpower and material resources.

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Abstract

The present application relates to a kind of compound preparation for preventing and treating poultry enteritis diarrhea, it is mainly made of the following weight parts proportion raw materials: catnip 10-12 parts, 10-12 parts of banlangen, 8-10 parts of heartleaf hedyotis, 10-12 parts of pepper, 10-15 parts of green wormwood, 8-10 parts of Chinese clematis, 10-12 parts of atractylodes, 3-5 parts of xylo-oligosaccharide, 1-3 parts of garlicin, 1-3 parts of capsaicin, 5-7 parts of vitamin C, 0.1-0.3 parts of vitamin A, 4-5 parts of bacillus licheniformis, 4-5 parts of butyric acid clostridium, 10-12 parts of brown sugar.The compound preparation can effectively improve the immune function of organism, prevent and treat diarrhea caused by poultry enteritis, improve intestinal health;While preparation enters organism, is easily absorbed, and clinical administration is convenient, suitable for group administration, save manpower and material resources.
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Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of feed additives, and mainly relates to a compound preparation for preventing and treating poultry enteritis and diarrhea and a preparation method thereof. BACKGROUND

[0002] Poultry enteritis is mainly caused by improper feeding management, feeding of moldy feed, excessive green feed, irregular feeding or overfeeding, and lack of sand, etc., and can be induced by sudden weather changes, cold, heat stroke, food poisoning, and certain parasites such as coccidia, roundworms and tapeworms.

[0003] Enteritis refers to inflammation of the intestinal mucosa, and is characterized by digestive dysfunction and diarrhea in clinic. The disease can occur in poultry of all ages, but is more common in 2-3 week old chicks and often causes mass death.

[0004] Most of the veterinary drugs on the market for preventing poultry enteritis and diarrhea are chemical drugs, various additives, etc. Chemical drugs have strong side effects and drug resistance during use, and also have defects such as high price and insignificant curative effect, and have certain limitations in use. Based on this, the present application is developed. SUMMARY

[0005] The present application aims to overcome the defects of the prior art, and provides a compound preparation for preventing and treating poultry enteritis and diarrhea, which can effectively improve the immune function of the body, prevent and treat diarrhea caused by poultry enteritis, and improve intestinal health. At the same time, the preparation is easily absorbed after entering the body, and is convenient for clinical administration, suitable for group administration, and saves manpower and material resources.

[0006] The second purpose of the present application is to provide a preparation method of the above-mentioned compound preparation.

[0007] The third purpose of the present application is to provide the effect of the above-mentioned compound preparation on chicken enteritis and diarrhea.

[0008] To achieve the above-mentioned purposes, the present application adopts the following technical solutions:

[0009] A compound preparation for preventing and treating poultry enteritis and diarrhea is prepared from the following raw materials in parts by weight: 10-12 parts of schizonepeta, 10-12 parts of isatis root, 8-10 parts of andrographis, 10-12 parts of zanthoxylum, 10-15 parts of artemisia, 8-10 parts of euphorbia humifusa, 10-12 parts of atractylodes, 3-5 parts of xylo-oligosaccharide, 1-3 parts of garlicin, 1-3 parts of capsaicin, 5-7 parts of vitamin C, 0.1-0.3 parts of vitamin A, 4-5 parts of bacillus licheniformis, 4-5 parts of clostridium butyricum, and 10-12 parts of brown sugar.

[0010] The present application provides a preparation method of the compound preparation for preventing and treating poultry enteritis and diarrhea, which comprises the following steps:

[0011] 1) Take catnip, Banlangen, Andrographis, Zanthoxylum, Artemisia annua, Chinese sumac, Atractylodes, wash, dry, crush and sieve;

[0012] 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, xylo-oligosaccharide, allicin, capsaicin, and mix well;

[0013] 3) Add an appropriate amount of soup, mix well (such as knead evenly, etc.), place in a fermentation tank for constant temperature fermentation, take out after fermentation, low temperature drying, add vitamin C and vitamin A, mix evenly, and get.

[0014] Specifically, in step 1), crush and sieve through 40-100 mesh.

[0015] Specifically, in step 3), constant temperature fermentation at 35℃±2℃ for 36-60 hours. The temperature for low temperature drying is 52-55℃.

[0016] Further, in step 3), the weight ratio of water and flour used to make the soup is 45-55:1, and the addition amount of the soup is 1.5-3 times the total weight of the 7 traditional Chinese medicines in step 1). The process of making the soup is as follows:

[0017] After the purified water is heated to boiling, add flour, stir well, keep boiling for 3-5 minutes, and cool down.

[0018] The application also provides a use method of the compound preparation for preventing and treating poultry enteritis and diarrhea, specifically: mixed feeding, 400-500 kg of compound preparation is mixed with 1 kg of compound preparation, once a day, for 7 days.

[0019] In the compound preparation formula, catnip is pungent, slightly warm, and diffuses into the lung and liver channels. It is good at dispelling wind-evil from the skin and blood, relieving the exterior, removing rash, stopping itching, and treating sores, and also dispelling internal wind to stop convulsions.

[0020] Banlangen is bitter and cold, and returns to the heart and stomach channels. It clears heat and resolves toxicity, cools blood and benefits the throat. It is used for wind-heat cold, sore throat, warm toxin rash, and yellow swelling poison. Banlangen has inhibitory effect on Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pneumococcus, and influenza bacillus.

[0021] Andrographis is bitter and cold, and returns to the heart, lung, large intestine, and bladder channels. It clears heat and resolves toxicity, and relieves swelling and pain. It is used for cold with fever, wet and hot diarrhea, snake and insect bites, and sores and boils. It can inhibit the rise of body temperature to achieve the effect of relieving fever, reduce the leakage of capillary walls to achieve the effect of anti-inflammatory, improve the phagocytic ability of white blood cells to improve immunity, and also has the effect of protecting liver and benefiting gallbladder, and has inhibitory effect on Pneumococcus, Escherichia coli, Streptococcus and many viruses.

[0022] Zanthoxylum bungeanum, pungent, warm, spleen, stomach, kidney. Warm and stop pain, kill insects and stop itching. For cold pain, cold and diarrhea, accumulation of worms; external treatment of eczema, scabies.

[0023] Artemisia vulgaris, bitter and cold, pungent and dispersing, liver and gallbladder. Clear and have, both virtual heat, and clear and hot, cool blood heat; both clear and resolve summer heat, and clear and resolve liver and gallbladder heat; both malaria, and transparent heat; both transparent and resolve heat, and transparent and resolve heat. Virtual heat, and clear and hot, and can be used.

[0024] Herba Humuli Scandentis, has the effects of clearing heat and resolving toxicity, cooling blood and stopping bleeding, and promoting diuresis. It is used for dysentery, diarrhea, hemoptysis, hematuria, hematochezia, metrorrhagia, furuncles, carbuncles and abscesses, and yellowish urine.

[0025] Atractylodes, bitter and pungent, warm, spleen, stomach, liver. Dry wet spleen, dispel wind and cold, eyesight. For diarrhea, edema, rheumatism, colds, night blindness. Can protect the gastric mucosa, regulate gastrointestinal motility and secretion, and have significant therapeutic effect on animals with spleen deficiency. It can also protect the liver, promote the secretion and excretion of bile, and has strong inhibitory effect on Escherichia coli, Shigella dysenteriae, Salmonella typhi, Staphylococcus aureus and many viruses.

[0026] Xylo-oligosaccharides can promote the proliferation of high selectivity nutrition bifidobacteria and prevent pathogenic bacteria from colonizing and invading. In vitro studies have shown that xylo-oligosaccharides can effectively proliferate bifidobacteria under strict anaerobic conditions using enzymatic xylo-oligosaccharides as carbon source.

[0027] Allicin has antibacterial and growth-promoting effects, low toxicity, no drug resistance, and no teratogenic, carcinogenic and mutagenic properties. It is a new type of additive that can replace antibiotics. Allicin has obvious inhibitory and killing effects on various pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Shigella dysenteriae.

[0028] Capsaicin has certain effects on the growth and intestinal morphology of chicks at a certain dose. Capsaicin can promote animal production performance by changing the structure of intestinal epithelial cells, and has obvious inhibitory effect on Escherichia coli in the ileum and jejunum of chicks, but has no effect on growth performance.

[0029] Vitamin C is essential for maintaining immune function, maintaining blood vessel integrity, and promoting non-heme iron absorption. It has obvious therapeutic effect on intestinal mucosal barrier function damage caused by endotoxin, and can significantly reduce the incidence and amount of intestinal bacterial colonization.

[0030] Vitamin A maintains the integrity of mucosal epithelial cells, repairs damaged mucosa, prevents pathogenic microorganisms from invading, and protects intestinal health.

[0031] Bacillus licheniformis, can adjust the imbalance of flora to achieve the purpose of treatment, can promote the body to produce antibacterial active substances, kill pathogenic bacteria. Can produce active substances, and has a unique biological oxygen stealing mechanism, can inhibit the growth and reproduction of pathogenic bacteria. It is suitable for intestinal flora imbalance caused by bacteria and intestinal health of breeding animals, and the effect on poultry animals is more obvious.

[0032] Clostridium butyricum, regulating intestinal microecological balance; enhancing immune function, promoting the growth of animals, improving the production performance and product quality of animals; promoting the growth of intestinal epithelial tissue cells.

[0033] Brown sugar contains various minerals and vitamins, which can enhance the appetite and digestive and absorptive capacity of livestock and poultry, help promote the growth and development and healthy growth of livestock and poultry. At the same time, brown sugar can increase the energy source of livestock and poultry, improve the physical strength and immunity of livestock and poultry, and improve the disease resistance of livestock and poultry.

[0034] The above drugs are based on the compatibility principle of monarch, minister, assistant and envoy, aiming to inhibit the proliferation of bacteria causing enteritis, improve intestinal health, and improve the immunity and disease resistance of chickens. The process of fermenting traditional Chinese medicine with soup further activates the pharmacological activity of traditional Chinese medicine and enhances the effect of the drug. The raw materials used are safe, effective, residue-free and green products.

[0035] Compared with the prior art, the compound preparation of the present application has the advantages and beneficial effects as follows:

[0036] (1) The use process of the present application is simple and suitable for production;

[0037] (2) The process of fermenting traditional Chinese medicine with soup in the present application enhances the effect of the product and improves the bioavailability;

[0038] (3) The compound preparation of the present application can effectively improve the immune function of the body, prevent and treat diarrhea caused by poultry enteritis, and improve intestinal health;

[0039] (4) The mixture of the present application is easily absorbed after entering the body, and the clinical administration is convenient, suitable for group administration, and saves manpower and material resources. DETAILED DESCRIPTION

[0040] The technical solutions of the present application are further described in detail in combination with the following examples, but the protection scope of the present application is not limited thereto.

[0041] In the following examples, if not otherwise specified, the raw materials used are ordinary commercially available products in the art or can be prepared by conventional techniques in the art. Some sources of raw materials are listed as follows.

[0042] Xylo-oligosaccharide (95%), item number xcsw019, purchased from Ningxia Xiangguo Biotechnology Co., Ltd.

[0043] Bacillus licheniformis (live bacteria number ≥100 billion CFU / g), Clostridium butyricum (live bacteria number ≥10 billion CFU / g), both purchased from Luoyang Oukobe Biotechnology Co., Ltd.

[0044] In the examples, the used face soup is prepared by the following method:

[0045] After the purified water is heated to boiling, the flour is added, stirred evenly, kept at a slight boil for 3-5 minutes, and cooled (it can be room temperature). It is ready.

[0046] Example 1. Compound preparation for preventing and treating poultry enteritis and diarrhea

[0047] A compound preparation for preventing and treating poultry enteritis and diarrhea is made from the following raw materials in the following proportions by weight:

[0048] 10 parts of catnip, 12 parts of radix isatidis, 8 parts of andrographis, 12 parts of pepper, 10 parts of artemisia, 10 parts of euphorbia humifusa, 10 parts of atractylodes, 5 parts of xylo-oligosaccharides, 1 part of garlicin, 3 parts of capsaicin, 5 parts of vitamin C, 0.3 parts of vitamin A, 4 parts of bacillus licheniformis, 5 parts of clostridium butyricum, and 10 parts of brown sugar.

[0049] The preparation method of the above-mentioned compound preparation for preventing and treating poultry enteritis and diarrhea comprises the following steps:

[0050] 1) Take catnip, radix isatidis, andrographis, pepper, artemisia, euphorbia humifusa, and atractylodes, wash, dry, and grind through a 60-mesh sieve;

[0051] 2) Add brown sugar, bacillus licheniformis, clostridium butyricum, xylo-oligosaccharides, garlicin, and capsaicin, and mix evenly;

[0052] 3) Add an appropriate amount of face soup, knead evenly, and place in a fermentation tank for constant temperature fermentation at 35℃±2℃ for 48 hours. After fermentation, take out, dry at low temperature, add vitamin C and vitamin A, and mix evenly to obtain the product of the present application.

[0053] In the preparation method, (1) the weight ratio of water to flour used in the face soup is 50:1. The amount of face soup is 2 times the total weight of the 7 traditional Chinese medicines in step 1).

[0054] (2) The temperature for low-temperature drying is between 52-55℃, and the moisture content is ≤10% after drying.

[0055] Example 2. Compound preparation for preventing and treating poultry enteritis and diarrhea

[0056] A compound preparation for preventing and treating poultry enteritis and diarrhea is made from the following raw materials in the following proportions by weight:

[0057] Bupleurum 12 parts, Radix Isatidis 10 parts, Andrographis 10 parts, Zanthoxylum 10 parts, Artemisia 15 parts, Euphorbia humifusa 8 parts, Atractylodes 12 parts, xylo-oligosaccharide 3 parts, garlicin 3 parts, capsaicin 1 part, vitamin C 7 parts, vitamin A 0.1 part, Bacillus licheniformis 5 parts, Clostridium butyricum 4 parts, brown sugar 12 parts.

[0058] The preparation method of the compound preparation for preventing and treating poultry enteritis and diarrhea comprises the following steps:

[0059] 1) Take Bupleurum, Radix Isatidis, Andrographis, Zanthoxylum, Artemisia, Euphorbia humifusa and Atractylodes, wash, dry, crush and pass through a 60-mesh sieve;

[0060] 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, xylo-oligosaccharide, garlicin and capsaicin and mix evenly;

[0061] 3) Further add an appropriate amount of face soup, knead evenly, place in a fermentation tank, ferment at a constant temperature of 35℃±2℃ for 48 hours, take out after fermentation, dry at low temperature, add vitamin C and vitamin A and mix evenly, thereby obtaining the product.

[0062] In the preparation method, (1) the weight ratio of water to flour in the face soup is 50:1, and the amount of the face soup is 2 times the total weight of the 7 traditional Chinese medicines in step 1).

[0063] (2) The temperature for low-temperature drying is between 52-55℃, and the drying is performed until the water content is less than or equal to 10%.

[0064] Example 3. Compound preparation for preventing and treating poultry enteritis and diarrhea

[0065] A compound preparation for preventing and treating poultry enteritis and diarrhea is prepared from the following raw materials in the weight proportions:

[0066] Bupleurum 11 parts, Radix Isatidis 11 parts, Andrographis 9 parts, Zanthoxylum 11 parts, Artemisia 12 parts, Euphorbia humifusa 9 parts, Atractylodes 11 parts, xylo-oligosaccharide 4 parts, garlicin 2 parts, capsaicin 2 parts, vitamin C 6 parts, vitamin A 0.2 part, Bacillus licheniformis 4 parts, Clostridium butyricum 5 parts, brown sugar 11 parts.

[0067] The preparation method of the compound preparation for preventing and treating poultry enteritis and diarrhea comprises the following steps:

[0068] 1) Take Bupleurum, Radix Isatidis, Andrographis, Zanthoxylum, Artemisia, Euphorbia humifusa and Atractylodes, wash, dry, crush and pass through a 60-mesh sieve;

[0069] 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, xylo-oligosaccharide, garlicin and capsaicin and mix evenly;

[0070] 3) add soup appropriate amount, knead, placed in fermentation tank, in 35℃±2℃ constant temperature fermentation 48 hours, after fermentation end, low temperature drying, add vitamin C and vitamin A, mix evenly, the product is obtained.

[0071] In the preparation method: (1) the weight ratio of water and flour used in the soup is 50:1. The amount of soup is 2 times the sum of the weights of the 7 traditional Chinese medicines in step 1).

[0072] (2) The temperature of low-temperature drying is between 52-55℃, and the moisture content is ≤10% after drying.

[0073] Example 1. Compound preparation for preventing and treating poultry enteritis and diarrhea

[0074] A compound preparation for preventing and treating poultry enteritis and diarrhea is made from the following raw materials in the following proportions by weight:

[0075] Bunge 11 parts, Banlangen 11 parts, Chuanxinlian 9 parts, Huajiao 11 parts, Qinghao 12 parts, Dijincao 9 parts, Cangzhu 11 parts, Oligosaccharide 4 parts, Garlicin 2 parts, Capsaicin 2 parts, Vitamin C 6 parts, Vitamin A 0.2 parts, Bacillus licheniformis 4 parts, Clostridium butyricum 5 parts, Brown sugar 11 parts.

[0076] The preparation method of the above-mentioned compound preparation for preventing and treating poultry enteritis and diarrhea comprises the following steps:

[0077] 1) Take Bunge, Banlangen, Chuanxinlian, Huajiao, Qinghao, Dijincao, and Cangzhu, wash, dry, and grind to pass through a 60-mesh sieve;

[0078] 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, oligosaccharide, garlicin, and capsaicin, and mix well;

[0079] 3) Add an appropriate amount of purified water, knead, place in a fermentation tank, and ferment at 35℃±2℃ for 48 hours. After fermentation, take out, low-temperature dry, add vitamin C and vitamin A, mix evenly, and the product is obtained.

[0080] In the preparation method: (1) the temperature of low-temperature drying is between 52-55℃, and the moisture content is ≤10% after drying.

[0081] (2) The amount of purified water is 2 times the sum of the weights of the 7 traditional Chinese medicines in step 1).

[0082] The difference between this preparation method and Example 3 is that no soup fermentation is used, and purified water is used instead of soup.

[0083] Example 2. Compound preparation for preventing and treating poultry enteritis and diarrhea

[0084] A compound preparation for preventing and treating poultry enteritis and diarrhea is prepared from the following raw materials in the following proportions by weight:

[0085] Bunge 11 parts, Andrographis 9 parts, Zanthoxylum 11 parts, Artemisia 12 parts, Euphorbia humifusa 9 parts, Atractylodes 11 parts, xylo-oligosaccharides 4 parts, allicin 2 parts, capsaicin 2 parts, vitamin C 6 parts, vitamin A 0.2 parts, Bacillus licheniformis 4 parts, Clostridium butyricum 5 parts, brown sugar 11 parts.

[0086] The preparation method of the compound preparation for preventing and treating poultry enteritis and diarrhea described above comprises the following steps:

[0087] 1) Take Bunge, Andrographis, Zanthoxylum, Artemisia, Euphorbia humifusa, and Atractylodes, wash, dry, and then super-micro pulverize to 200 mesh;

[0088] 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, xylo-oligosaccharides, allicin, capsaicin, vitamin A, and vitamin C, and mix well; the control product is obtained.

[0089] The preparation method is different from that of Example 3 in that a super-micro pulverization process is adopted, and no traditional Chinese medicine fermentation process is adopted.

[0090] Test Example. Influence on diarrhea caused by chicken enteritis

[0091] The following methods are used:

[0092] (I) Drug and reagent

[0093] Test drug: the compound preparation prepared in Examples 1, 2, and 3;

[0094] Control drug: the compound preparation prepared in Control Examples 1 and 2.

[0095] (II) Test method

[0096] (1) Test design: 500 sick chickens with the following symptoms are selected and randomly divided into 5 groups.

[0097] Symptoms: sick chickens are dull, with drooping wings, retracted neck, closed eyes, and messy feathers, and are unwilling to move. With the increase of the number of days of illness, the chicken body gradually becomes emaciated, the comb and leg skin are pale, and the feed intake is reduced; the chicken produces watery and loose stool or feed-like stool, and severe cases produce deep brown or red carrot-like stool with a pungent and foul odor.

[0098] The test group uses a basic daily ration, and the use methods of Examples 1, 2, and 3 are all as follows: mixed feeding, 50 kg of feed per 100 g of drug.

[0099] Control group 1 is a basic daily ration + 0.2% of Control Example 1.

[0100] Control group 2 is base diet + 0.2% of control example 2.

[0101] Test cycle: 7 days.

[0102] The base diet formula and its nutritional ingredients are shown in Table 1. The feeding management adopts 3-layer cage raising, and other management is carried out according to the large-scale broiler production management system.

[0103] Table 1 Base diet formula and nutritional ingredients

[0104]

[0105] (2) Test index: dead and discarded chicken number, treatment effect (ineffective rate, effective rate, cure rate).

[0106] Ineffective: the symptoms of sick chickens did not alleviate.

[0107] Effective: the feed intake increased, and the defecation condition improved obviously.

[0108] Cured: the feed intake increased obviously, and the defecation condition was normal.

[0109] (3) Test results: see Table 2 below.

[0110] Table 2 Comparison of drug effect

[0111]

[0112] As can be seen from Table 2, the average cure rate of the test group is 78.6%, which is increased by 9.6% and 29.6% respectively compared with control group 1 and control group 2, and the difference is significant; the average effective rate of the test group is 93%, which is increased by 9% and 21% respectively compared with control group 1 and control group 2, and the difference is significant; the dead and discarded chicken number of the test group is 3.3 on average, which is reduced by 1.6 and 3.6 respectively compared with control group 1 and control group 2. The treatment effect of the compound preparation prepared by the pure water fermentation process of control group 1 is better than that of the compound preparation prepared by the ultrafine grinding process of control group 2.

[0113] As can be seen from the above, the compound preparation formula and the corresponding surface soup fermentation process can effectively improve the immune function of the body, prevent and treat diarrhea caused by poultry enteritis, improve intestinal health, thereby significantly enhancing the product effect and improving the bioavailability.

Claims

1. A compound preparation for preventing and treating poultry enteritis and diarrhea, characterized in that: The invention is prepared from the following raw materials in parts by weight: 10-12 parts of schizonepeta, 10-12 parts of isatis root, 8-10 parts of andrographis paniculata, 10-12 parts of zanthoxylum bungeanum, 10-15 parts of artemisia annua, 8-10 parts of euphorbia euphorbiae, 10-12 parts of atractylodes, 3-5 parts of xylo-oligosaccharides, 1-3 parts of allicin, 1-3 parts of capsaicin, 5-7 parts of vitamin C, 0.1-0.3 parts of vitamin A, 4-5 parts of Bacillus licheniformis, 4-5 parts of Clostridium butyricum, and 10-12 parts of brown sugar. The preparation method of the compound preparation for preventing and treating poultry enteritis and diarrhea comprises the following steps: 1) Wash, dry, crush and sieve Nepeta tenuifolia, Radix Isatidis, Andrographis paniculata, Zanthoxylum bungeanum, Artemisia annua, Herba Euphorbiae rutaecarpa, and Atractylodes lancea. 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, xylooligosaccharides, allicin, and capsaicin and mix well; 3) Add appropriate amount of noodle soup, mix well, place in a fermentation tank for constant temperature fermentation, take out after fermentation, dry, add vitamin C and vitamin A, mix well, and you have it; In step 1), the powder is crushed through a 40-100 mesh sieve; In step 3), ferment at a constant temperature of 35°C ± 2°C for 36-60 hours; In step 3), the weight ratio of water to noodles used in making noodle soup is 45-55:1, and the amount of noodle soup added is 1.5-3 times the total weight of the 7 Chinese herbs in step 1).

2. The method for preparing the compound preparation for preventing and treating poultry enteritis and diarrhea according to claim 1, characterized in that: The steps include: 1) Wash, dry, crush and sieve Nepeta tenuifolia, Radix Isatidis, Andrographis paniculata, Zanthoxylum bungeanum, Artemisia annua, Herba Euphorbiae rutaecarpa, and Atractylodes lancea. 2) Add brown sugar, Bacillus licheniformis, Clostridium butyricum, xylooligosaccharides, allicin, and capsaicin and mix well; 3) Add appropriate amount of noodle soup, mix well, place in a fermentation tank for constant temperature fermentation, take out after fermentation, dry, add vitamin C and vitamin A, mix well, and you have it; In step 1), the powder is crushed through a 40-100 mesh sieve; In step 3), ferment at a constant temperature of 35°C ± 2°C for 36-60 hours; In step 3), the weight ratio of water to noodles used in making noodle soup is 45-55:1, and the amount of noodle soup added is 1.5-3 times the total weight of the 7 Chinese herbs in step 1).

3. The method for preparing the compound preparation for preventing and treating poultry enteritis and diarrhea according to claim 2, wherein: In step 3), the drying temperature is 52-55°C.

Citation Information

Patent Citations

  • Intestinal tract health-care agent for improving health of intestinal tracts of chickens and preparation method of intestinal tract health-care agent

    CN107897512A