A liquid dripping device for a tape-type sealing machine

Abstract

The present application discloses a liquid dripping device for a tape-type sealing machine, the liquid dripping device comprising a slide rail for carrying a glass slide, a liquid dripping assembly containing a reagent, and a liquid dripping tube connected to the liquid dripping assembly, the liquid dripping assembly comprising a liquid dripping bottle containing the reagent and a pump body, the pump body having an input end connected to the liquid dripping bottle and an output end connected to the liquid dripping tube, the input end being connected to the liquid dripping bottle through a liquid inlet tube; the liquid dripping device also comprises a block arranged at the slide rail, the end of the liquid dripping tube is located above the block, and the projection of the end of the liquid dripping tube in the vertical direction is located in the middle of the block, the glass slide is pushed to abut against the block, and the block can drive the glass slide to move so that the glass slide passes through the end of the liquid dripping tube in sequence, wherein the reagent at the nozzle of the liquid dripping tube and the reagent dripped onto the glass slide are in a continuous state. During dripping, the consistency of the reagent at the glass slide can be ensured, so that the reagent dripped onto the glass slide is relatively uniform.

Description

Technical Field

[0001] The invention belongs to the field of medical pathology detection, and in particular relates to a liquid dripping device of a tape-type sealing machine. Background Art

[0002] When using a tape-type coverslipper to create specimen slides, a sealing agent is dripped onto the slide. The tape reacts with the sealing agent to produce a glass glue that bonds to the slide to create the specimen slide. During this bonding process, uneven dripping can lead to various problems, including bubbles, glue overflow, fingerprints, foreign matter, tissue debris, tape misalignment, and tape jams. Severe tape misalignment and jams can lead to tape fragmentation, reducing the sealing efficiency and quality of the coverslipper, affecting slide interpretation and diagnosis. Summary of the Invention

[0003] In view of the above-mentioned deficiencies, the present invention provides a liquid dripping device for a tape-type sealing machine.

[0004] The present invention is achieved through the following technical solutions:

[0005] A tape-type sealing machine dripping device, the dripping device includes a slide rail for carrying a glass slide, a dripping assembly containing a reagent, and a dripping tube connected to the dripping assembly, the dripping assembly includes a dripping bottle containing the reagent and a pump body, the pump body has an input end connected to the dripping bottle and an output end connected to the dripping tube, the input end is connected to the dripping bottle through an inlet tube; the dripping device also includes a block arranged on the slide rail, the end of the dripping tube is located above the block, and the projection of the end of the dripping tube in the vertical direction is located in the middle of the block, the glass slide is pushed to abut against the block, and the block can drive the glass slide to move so that the glass slide passes through the end of the dripping tube in sequence, wherein the reagent at the tube mouth of the dripping tube and the reagent dripped onto the glass slide are in a continuous state. By setting up a pump body, the speed at which the reagent is transported to the dropper can also be controlled, and the dripping speed and dripping amount of the reagent dripping onto the glass slide can be adjusted, so that the amount of reagent dripping onto the glass slide can match the size of the glass slide and the tape, and the dripping of the reagent is more accurate. At the same time, when the reagent is dripped, it will be discharged from the port of the dropper, and the reagent at the mouth of the dropper and the reagent dripped onto the glass slide are in a continuous state. Therefore, the continuity of the reagent on the glass slide can be guaranteed during dripping, so that the reagent dripped onto the glass slide is relatively uniform.

[0006] Furthermore, the dropper device also includes a first sensor and a second sensor arranged in sequence along the extension direction of the slide, and the glass slide can trigger the first sensor and the second sensor in sequence. By providing the first and second sensors, the position of the glass slide can be detected. When the glass slide triggers the first sensor, it means that the glass slide has been pushed to the slide. When the glass slide moves a certain distance and triggers the second sensor, it means that the glass slide is moving smoothly, thereby ensuring that the reagent is accurately dripped onto the glass slide.

[0007] Furthermore, the dripping device further includes a guide rod and a reverse thrust block disposed on the guide rod, the reverse thrust block being connected to the stopper so as to move synchronously with the stopper and the reverse thrust block, and a return spring being sleeved on the guide rod and abutting against the reverse thrust block. Since the stopper abuts against the glass slide, when the glass slide moves from the first sensor toward the second sensor, it also drives the stopper to move, and moves the glass slide away from the end of the drip tube. Therefore, after testing the position and movement of the glass slide, it is necessary to move the glass slide in the opposite direction so that the glass slide reaches the bottom of the drip tube. Therefore, by providing the reverse thrust block, when the stopper moves driven by the glass slide, it can drive the reverse thrust block to move together with it. At the same time, a return spring is provided on the guide rod. When the reverse thrust block moves, the return spring is compressed. Therefore, when the glass slide is reset, the return spring can push the reverse thrust block, thereby ensuring that the stopper always abuts against the glass slide when the glass slide is reset.

[0008] Furthermore, the reverse push block is arranged between the first sensor and the second sensor, so that the reverse push block can be triggered in time when the slide moves, and the reverse push block is located between the first sensor and the second sensor, so that when the slide moves to the second sensor, the return spring will not be over-compressed.

[0009] Furthermore, the inner diameter of the liquid inlet tube is 2.8-3.2mm, and the inner diameter of the dropper tube is 0.8-1.2mm. The liquid inlet tube is a rubber inlet tube, and the dropper tube is a metal dropper tube. The liquid inlet tube connects the pump body and the dropper bottle storing the reagent. Therefore, the liquid inlet tube is large in size to ensure that the pump body can fully supply the reagent to the dropper tube. The dropper tube is made of metal, which can ensure that the reagent in the dropper tube flows more smoothly during operation, avoiding the actual flow difficulty caused by the dropper tube bending.

[0010] Furthermore, the distance between the end of the dropper and the upper surface of the slide is 1 mm. By shortening the distance between the dropper and the slide, the distance between the end of the dropper and the glass slide located on the slide is kept short. Therefore, when the dropper drips the reagent onto the glass slide, a capillary phenomenon occurs, thereby ensuring that the reagent at the dropper nozzle and the reagent dripped onto the glass slide are in a continuous state.

[0011] Furthermore, the slide is moved along the slide rail by the push rod. The slide rail includes a slide track for the slide to slide and a push rod track located below the slide track. A stop block is located between the slide track and the push rod track. The push rod track is located below, so when the push rod pushes the slide to move, it will be located below the slide, thereby not affecting the dripping of reagents on the upper side of the slide. At the same time, the slide is pushed by the push rod, that is, the push rod will also abut against the slide. When the push rod moves in a direction away from the slide, the reverse push block will be driven by the return spring to push the slide toward the push rod through the stop block. At this time, both the stop block and the push rod will abut against the slide, which has a better limiting effect on the slide.

[0012] The present invention also provides a dripping control method for the above dripping device, the dripping control method comprising:

[0013] S1: Push the slide to the slide rail, determine the required tape length and the amount of liquid reagent to be added for sealing, calculate the slide movement speed and liquid dripping speed, and set the position where the first drop of reagent will land on the slide;

[0014] S2: According to the acceleration and deceleration of the drop, the drop speed and the moving speed of the slide are reversely corrected;

[0015] S3: Replenish the reagent volume according to the sealing time and the volatilization amount of the reagent;

[0016] S4: Use the dropper to drop the reagent onto the glass slide.

[0017] Furthermore, in S1 , the first drop of reagent is dropped onto the glass slide at the end of the glass slide.

[0018] Furthermore, in S2, the deceleration of the dripping is calculated based on the dripping speed of the first drop of reagent, the sliding dripping speed, the tape length and the sealing speed, wherein the sliding dripping speed is the moving speed of the reagent at the nozzle of the drip tube on the glass slide during the sliding process of the glass slide. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A schematic front view illustrating an exemplary embodiment of the liquid dropping device of the present invention;

[0020] Figure 2 A schematic top view illustrating an exemplary embodiment of the liquid dropping device of the present invention;

[0021] Figure 3 A schematic flow chart illustrating an exemplary embodiment of the dripping control method of the present invention.

[0022] Reference numerals:

[0023] 1. Slide rail, 21. Dropper bottle, 22. Pump body, 23. Liquid inlet pipe, 3. Dropper, 4. Stop block, 5. First sensor, 6. Second sensor, 7. Guide rod, 8. Return spring, 9. Back thrust block, 10. Push rod. DETAILED DESCRIPTION

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0025] It should be noted that the directional terms such as left, right, up, down, front and back in the embodiments of the present invention are merely relative concepts or are based on the normal use state of the product, that is, the direction of movement of the product, and should not be considered as limiting.

[0026] In addition, it should be noted that the dynamic terms such as "relative motion" mentioned in the embodiments of the present invention not only refer to changes in position, but also include movements such as rotation and rolling in which there is no relative change in position but the state changes.

[0027] Finally, it should be noted that when a component is referred to as being "located on" or "disposed on" another component, it can be on the other component or there may be an intervening component. When a component is referred to as being "connected to" another component, it can be directly connected to the other component or there may be an intervening component.

[0028] like Figures 1 to 3 The dripping device of the tape-type sealing machine shown in the figure has a dripping control method, the dripping device includes a slide 11 for carrying a glass slide, a dripping assembly containing a reagent, and a dripping tube 3 connected to the dripping assembly, the dripping assembly includes a dripping bottle 21 containing the reagent and a pump body 22, the pump body 22 has an input end connected to the dripping bottle 21 and an output end connected to the dripping tube 3, the input end is connected to the dripping bottle 21 through the liquid inlet tube 23; the dripping device also includes a stopper 4 arranged on the slide 11, the end of the dripping tube 3 is located above the stopper 4, and the dripping tube 3 The projection of the end portion in the vertical direction is located in the middle of the stopper 4, and the glass slide is pushed to abut against the stopper 4, and the stopper 4 can drive the glass slide to move so that the glass slide passes through the end portion of the dropper tube 3 in sequence, wherein the reagent at the nozzle of the dropper tube 3 and the reagent dripped onto the glass slide are in a continuous state; compared with the traditional glass slide packaging, the traditional packaging method is to use a glass cover glass to be placed on the glass slide, and the drying time of the glass slide is long, which affects the sealing efficiency of the glass slide. In this application, the packaging is performed by tape, the drying time is shortened, and the sealing efficiency of the glass slide is thereby improved.

[0029] When sealing the slide with tape, the tape will react with the reagent to produce glass glue, which will adhere to the glass slide to finally form a specimen slide. Therefore, during the process of adding the reagent, it is necessary to ensure that the reagent is added evenly to facilitate subsequent reading and diagnosis. In this application, the glass slide to be sealed can be transported to the slide rail 11, and the glass slide can move along the slide rail 11, so that the entire glass slide can be located at the lower side of the dropper 3, so that the reagent added at the dropper 3 can better cover the glass slide, and a pump body 22 is provided between the dropper 3 and the dropping bottle 21, and the pump body 22 can remove the reagent in the dropping bottle 21 and transport it to The dropper 3 is provided with reagents, and at the same time, by setting the pump body 22, the speed of the reagent being delivered to the dropper 3 can also be controlled, and the dripping speed and dripping amount of the reagent dripping onto the glass slide can be adjusted, so that the amount of reagent dripping onto the glass slide can match the size of the glass slide and the tape, and the dripping of the reagent is more accurate. At the same time, when the reagent is dripped, it will be discharged from the port of the dropper 3, and the reagent at the mouth of the dropper 3 and the reagent dripped onto the glass slide are in a continuous state. Therefore, the continuity of the reagent on the glass slide can be guaranteed during dripping, so that the reagent dripped onto the glass slide is relatively uniform.

[0030] As a preferred embodiment of the present application, the inner diameter of the liquid inlet tube 23 is 2.8~3.2mm, the inner diameter of the dropper tube 3 is 0.8~1.2mm, the inner diameter of the liquid inlet tube 23 is preferably 3mm, the inner diameter of the dropper tube 3 is preferably 1mm, and the liquid inlet tube 23 is a rubber liquid inlet tube 23, and the dropper tube 3 is a metal dropper tube 3; the liquid inlet tube 23 is connected to the pump body 22 and the dropper bottle 21 storing the reagent, so the liquid inlet tube 23 is larger in size, ensuring that the pump body 22 can fully provide the reagent to the dropper tube 3, and the dropper tube 3 is made of metal, so it can ensure that the reagent in the dropper tube 3 is more coherent when flowing, avoiding the bending of the dropper tube 3 and causing actual flow difficulties.

[0031] As a preferred embodiment of the present application, the distance between the end of the dropper tube 3 and the upper surface of the slide rail 11 is 1 mm; by shortening the distance between the dropper tube 3 and the slide rail 11, the distance between the end of the dropper tube 3 and the glass slide located on the slide rail 11 is ensured to be short. Therefore, when the dropper tube 3 drips the reagent onto the glass slide, a capillary phenomenon will occur, thereby ensuring that the reagent at the mouth of the dropper tube 3 and the reagent dripped onto the glass slide are in a continuous state.

[0032] In the present application, the dripping device also includes a first sensor 5 and a second sensor 6 arranged in sequence along the extension direction of the slide rail 11, and the glass slide can trigger the first sensor 5 and the second sensor 6 in sequence; by setting the first sensor 5 and the second sensor 6, the position of the glass slide can be detected. When the glass slide triggers the first sensor 5, it means that the glass slide has been pushed to the slide rail 11, and when the glass slide moves a certain distance and triggers the second sensor 6, it means that the movement of the glass slide is in a smooth state, thereby providing a guarantee for the reagent to be accurately dripped on the glass slide.

[0033] As an embodiment of the present application, the dripping device also includes a guide rod 7 and a reverse push block 9 arranged at the guide rod 7, the reverse push block 9 is connected to the stop block 4 so as to move synchronously with the stop block 4 and the reverse push block 9, and a return spring 8 is provided at the guide rod 7. Since the stop block 4 abuts against the glass slide, when the glass slide moves from the first sensor 5 toward the second sensor 6, it will also drive the stop block 4 to move, and will make the glass slide away from the end of the dropper 3. Therefore, after testing the position and movement of the glass slide, it is necessary to move the glass slide in the opposite direction so that the glass slide reaches the bottom of the dropper 3. Therefore, by setting the reverse push block 9, when the stop block 4 moves driven by the glass slide, it can drive the reverse push block 9 to move together, and at the same time, a return spring 8 is set at the guide rod 7. When the reverse push block 9 moves, the return spring 8 will be compressed. Therefore, when the glass slide is reset, the return spring 8 can push the reverse push block 9, thereby enabling the stop block 4 to always abut against the glass slide when the glass slide is reset.

[0034] Preferably, the reverse push block 9 is arranged between the first sensor 5 and the second sensor 6; it can trigger the reverse push block 9 in time when the glass slide moves, and at the same time, the reverse push block 9 is located between the first sensor 5 and the second sensor 6, so that when the glass slide moves to the second sensor 6, it will not cause excessive compression of the reset spring 8.

[0035] As an embodiment of the present application, the glass slide is moved along the slide rail 11 by the push rod 10. The slide rail 11 includes a glass slide track for the glass slide to slide and a push rod track located at the lower side of the glass slide track, and the stopper 4 is located between the glass slide track and the push rod track; wherein, the push rod track is located on the lower side, so that when the push rod 10 pushes the glass slide to move, it will be located at the lower side of the glass slide, thereby not affecting the dripping of the reagent on the upper side of the glass slide. At the same time, the glass slide is pushed by the push rod 10, that is, the push rod 10 will also abut against the glass slide. When the push rod 10 moves in the direction away from the glass slide, the reverse push block 9 will be driven by the reset spring 8 to push the glass slide toward the push rod 10 through the stopper 4. At this time, the stopper 4 and the push rod 10 will also abut against the glass slide, which has a better limiting effect on the glass slide.

[0036] The present invention also provides a dripping control method for the above dripping device, the dripping control method comprising:

[0037] S1: Push the slide to the slide rail, determine the required tape length and the amount of liquid reagent to be added for sealing, calculate the slide movement speed and liquid dripping speed, and set the position where the first drop of reagent will land on the slide;

[0038] S2: According to the acceleration and deceleration of the drop, the drop speed and the moving speed of the slide are reversely corrected;

[0039] S3: Replenish the reagent volume according to the sealing time and the volatilization amount of the reagent;

[0040] S4: Use the dropper to drop the reagent onto the glass slide.

[0041] As a preferred embodiment of the present application, in S1 , the first drop of reagent is dropped onto the glass slide at the end of the glass slide.

[0042] As a preferred embodiment of the present application, in S2, the deceleration of the dripping is calculated based on the dripping speed of the first drop of reagent, the sliding dripping speed, the tape length and the sealing speed, wherein the sliding dripping speed is the moving speed of the reagent at the nozzle of the dropper on the glass slide during the sliding process of the glass slide.

[0043] The following describes the specific dripping process on a glass slide as an example.

[0044] The drip tube is made of 1mm inner diameter stainless steel tubing. One end is connected to the pump body, and the other end is located 1mm above the slide rail. The parameter calculation method based on the usage scenario is as follows.

[0045] Estimate the critical state of the reagent drop and calculate the diameter of the drop. According to the balance between surface tension and gravity at the critical state of actual drop:

[0046]

[0047] where r is the droplet radius, ρ is the reagent density 0.868 g / mL, and g is the acceleration due to gravity.

[0048] According to calculations, to ensure continuity between the reagent droplet and the slide, the droplet diameter should be no larger than 4 mm. To better control the droplet volume and shape, the height between the dropper nozzle and the slide must be less than the droplet diameter. The ability of the reagent droplet to dissolve the tape was estimated using droplets with diameters of 1 mm, 2 mm, and 3 mm.

[0049]

[0050] Where B0 is the relative size of surface gravity and surface tension, and ω is the dimensionless radius of the droplet, the volume formula of the separated droplet is obtained:

[0051] ,in

[0052] Drop diameter 1mm: V = 7.8uL

[0053] Drop diameter 2mm: V = 14.0uL

[0054] Drop diameter 3mm: V = 20.0uL

[0055] Based on the thickness of the glass glue and the dissolving power of the reagents used in this application, it was calculated that 16uL of reagent was required to dissolve a 60mm length of tape. A large amount of reagent was required at the front of the tape to prevent bubbles from forming during sealing, so the first drop of reagent required about half that amount, or 8uL. When using a dropper with a 1mm inner diameter, to ensure the first drop of liquid drips quickly, the height from the slide was 1mm, which, combined with the slide thickness, equals 2mm.

[0056] Before dripping, the length of the sealing tape and the amount of reagent to be dripped are set. Based on the above parameters, the dripping position, dripping speed, dripping acceleration, dripping deceleration, and liquid replenishment amount are calculated to determine different dripping methods.

[0057] Set the drip acceleration to 10 times the drip speed to ensure that the drip speed can reach the target in the shortest time.

[0058]

[0059] Where Vp is the sealing speed, Vds is the dripping speed, A is the set dripping volume, and L is the tape length. The dripping speed can be calculated based on the above equation. However, the formation and landing of the first drop require time, so the position and speed of the slide's retraction under the action of the stopper must be considered to ensure that the first drop lands precisely on the end of the slide.

[0060]

[0061] Wherein, Vp is the speed of sealing, Vdf is the dripping speed of the first drop, A is the set dripping amount, and S is the distance between the glass slide and the end of the dropper.

[0062] After the first drop of liquid falls, according to the capillary phenomenon, liquids and solids with similar chemical properties can penetrate each other. Assuming that the volume of the first drop of liquid is infinite, a 1mm diameter wool metal tube is inserted into it. The water pumping height of the capillary is calculated as:

[0063]

[0064] Here, h is the capillary pumping height, and r is the dropper radius (in actual dripping, there is liquid in the tube, so the tube diameter can be directly used for calculation). Calculation yields h = 5 mm. However, in this application, the distance between the end of the dropper and the glass slide is approximately 1 mm. Therefore, after the first drop is dripped, the reagent between the glass slide and the dripping port is in a three-point connection, meaning that the reagent at the dropper port and the reagent dripped onto the glass slide are in a continuous state.

[0065] The deceleration a1 of the droplet is calculated based on the first droplet velocity, the sliding droplet velocity, the sealing length, and the sealing velocity:

[0066]

[0067] Since the reagent in the droplet will evaporate, the amount of reagent evaporation is calculated according to the sealing time, and the amount of droplet is supplemented based on the amount of reagent evaporation:

[0068]

[0069] Where G is the amount of organic matter volatilized, V is the wind speed at the liquid surface, pH is the saturated vapor pressure of the organic matter at room temperature, F is the exposed area of ​​the organic matter, and M is the molecular weight. The calculated volatilization rate is 13.8 uL / s.

[0070] The foregoing is merely an embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various changes and variations. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should all be included within the scope of the claims of the present application.

Claims

1. A dripping device for a tape-type sealing machine, characterized in that: The dripping device includes a slide rail for carrying a glass slide, a dripping assembly containing a reagent, and a dripping tube connected to the dripping assembly. The dripping assembly includes a dripping bottle containing the reagent and a pump body. The pump body has an input end connected to the dripping bottle and an output end connected to the dripping tube. The input end is connected to the dripping bottle through an inlet tube. The dripping device further includes a stopper provided at the slide rail, the end of the dripping tube being located above the stopper, and the projection of the end of the dripping tube in the vertical direction being located in the middle of the stopper, the glass slide being pushed until it abuts against the stopper, and the stopper can drive the glass slide to move so that the glass slide passes the end of the dripping tube in sequence, wherein the reagent at the nozzle of the dripping tube and the reagent dripped onto the glass slide are in a continuous state; The dripping method performed by the dripping device includes: S1: Push the slide to the slide rail, determine the tape length required for sealing and the amount of liquid reagent to be added, calculate the slide movement speed and liquid dripping speed, and set the position where the first drop of reagent is dropped on the slide; S2: According to the acceleration and deceleration of the drop, the drop speed and the moving speed of the slide are reversely corrected; S3: Replenish the reagent volume according to the sealing time and the volatilization amount of the reagent; S4: Use the dropper to drop the reagent onto the glass slide.

2. The liquid dripping device of a tape-type sealing machine according to claim 1, characterized in that: The dropper device further includes a first sensor and a second sensor sequentially arranged along the extending direction of the slide rail, and the glass slide can trigger the first sensor and the second sensor in sequence.

3. The liquid dripping device of a tape-type sealing machine according to claim 2, characterized in that: The dripping device also includes a guide rod and a reverse thrust block arranged at the guide rod, the reverse thrust block is connected to the stop block to move synchronously with the stop block and the reverse thrust block, and a return spring is sleeved on the guide rod and abuts against the reverse thrust block.

4. The liquid dripping device of a tape-type sealing machine according to claim 3, characterized in that: The reverse thrust block is arranged between the first sensor and the second sensor.

5. The liquid dripping device of a tape-type sealing machine according to claim 1, characterized in that: The inner diameter of the liquid inlet pipe is 2.8-3.2 mm, the inner diameter of the liquid dropper is 0.8-1.2 mm, the liquid inlet pipe is a rubber liquid inlet pipe, and the liquid dropper is a metal liquid dropper.

6. The liquid dripping device of a tape-type sealing machine according to claim 1, characterized in that: The distance between the end of the drip tube and the upper surface of the slide rail is 1 mm.

7. The liquid dripping device of a tape-type sealing machine according to claim 1, characterized in that: The glass slide moves along the slide rail by means of a push rod. The slide rail comprises a glass slide track for the glass slide to slide and a push rod track located at the lower side of the glass slide track. The stopper is located between the glass slide track and the push rod track.

8. The liquid dripping device of a tape-type sealing machine according to claim 1, characterized in that: In S1, the first drop of reagent is dropped onto the slide at the end of the slide.

9. The liquid dripping device of a tape-type sealing machine according to claim 1, characterized in that: In S2, the deceleration of the dripping is calculated based on the dripping speed of the first drop of reagent, the sliding dripping speed, the tape length and the sealing speed. The sliding dripping speed is the speed at which the reagent at the nozzle of the drip tube moves on the glass slide during the sliding process of the glass slide.

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