Composition that helps digestion and preparation method thereof

Abstract

The invention discloses a composition that helps digestion. The Chinese medicinal extract is prepared from the following Chinese medicinal components by weight: 20-30 parts of Atractylodes macrocephala, 25-35 parts of Dioscorea opposita, 18-22 parts of Amomum villosum, 15-25 parts of Coix seeds, 12-16 parts of Bupleurum chinense, 20-30 parts of Scutellaria baicalensis, 15-25 parts of Artemisia capillaris, etc. The composition can dry out dampness and strengthen the spleen, soothe the liver and promote bile secretion, relieve stagnation and relieve constipation, regulate qi and resolve phlegm, dry dampness and resolve phlegm, regulate qi and eliminate stagnation, eliminate fullness and relieve chest tightness, regulate the ascending and descending of qi, relieve exterior and interior, and relieve abdominal distension. The combination of the Chinese medicinal extracts is mutually beneficial, and the composition can treat abdominal distension caused by internal obstruction of phlegm and dampness. The preparation method and use of the composition are also disclosed.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, in particular to a composition that helps digestion and a preparation method thereof. Background Art

[0002] Piman (pi pi wan) is a condition characterized by abdominal distension and discomfort due to spleen and stomach dysfunction, impaired ascending and descending functions, and stagnation of gastric qi. Its clinical characteristics are a sense of fullness, a feeling of fullness that is invisible to the touch, tender to the touch, and painless to pressure. Its clinical manifestations are similar to those of Western medicine's chronic gastritis (including superficial gastritis and atrophic gastritis), functional dyspepsia, and gastroptosis, which present with abdominal distension and discomfort as their primary symptoms.

[0003] The invention patent with application number 2021114924255 discloses a preparation process of a traditional Chinese medicine composition for treating stomachache and fullness, including the following steps: 1: processing of raw materials, the raw materials include dendrobium, white peony, phellodendron, southern ginseng, hawthorn, polygonatum, fructus aurantii (fried), and licorice; the raw materials are cleaned, cut, dried, and processed and then enter the clean material warehouse; 2: fine processing of dendrobium, white peony, and phellodendron; dendrobium, white peony, and phellodendron are coarsely crushed, pulverized, sterilized, and processed into fine powder by integrated processing equipment, and then the materials are added to the raw and auxiliary material warehouse for storage; different processing methods can be used according to different raw materials, so that various raw materials can be processed more quickly, thereby improving production efficiency, and further providing a more scientific preparation process for drug processing, which can greatly reduce the loss of medicinal gas during the production process, ensure the medicinal properties, and do not disclose the syndrome of stomachache and fullness. Patent application number 2016101386997 discloses a traditional Chinese medicine composition for treating damp-heat-blocking stomach-type fullness and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 10-12 parts of rhubarb, 8-10 parts of ginger magnolia bark, 12-15 parts of calamus, 12-15 parts of pinellia, 6-8 parts of gardenia, 4-6 parts of coptis root, 9-13 parts of mistletoe, and 3-5 parts of cicada shell. The present invention also provides a preparation method for the traditional Chinese medicine composition for treating damp-heat-blocking stomach-type fullness. The traditional Chinese medicine composition for treating damp-heat-blocking stomach-type fullness of the present invention has a good therapeutic effect on patients with damp-heat-blocking stomach-type fullness, with a cure rate of 91.2% and a total effective rate of 100%. The composition is simple in prescription and has no toxic side effects. However, the composition does not disclose its treatment principles, and its credibility is poor. Summary of the Invention

[0004] The object of the present invention is to provide a composition that helps digestion and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A composition for facilitating digestion, wherein the Chinese medicinal extract is prepared from the following Chinese medicinal components by weight: 20-30 parts of Atractylodes macrocephala, 25-35 parts of Dioscorea opposita, 18-22 parts of Amomum villosum, 15-25 parts of Coix seeds, 12-16 parts of Bupleurum chinense, 20-30 parts of Scutellaria baicalensis, 15-25 parts of Artemisia capillaris, 20-30 parts of Polygonum cuspidatum, 15-25 parts of Pinellia ternata, 20-30 parts of Tangerine peel, 18-22 parts of Arisaema consanguineum, 15-25 parts of Perilla seeds, 20-30 parts of Rhubarb, 12-16 parts of Areca catechu, 20-30 parts of Cassia seeds, 15-25 parts of Prunus mume seeds, 12-16 parts of Magnolia officinalis, 20-30 parts of Perilla leaves, 10-20 parts of Costus root, and 12-18 parts of Cyperus rotundus.

[0007] The composition for facilitating digestion is prepared from the following Chinese medicinal components by weight: 25 parts of Atractylodes macrocephala, 30 parts of Dioscorea opposita, 20 parts of Amomum villosum, 20 parts of Coix seeds, 14 parts of Bupleurum chinense, 25 parts of Scutellaria baicalensis, 20 parts of Artemisia capillaris, 25 parts of Polygonum cuspidatum, 20 parts of Pinellia ternata, 25 parts of Tangerine peel, 20 parts of Arisaema consanguineum, 20 parts of Perilla seeds, 25 parts of Rhubarb, 14 parts of Areca catechu, 25 parts of Cassia seeds, 20 parts of Prunus mume seeds, 14 parts of Magnolia officinalis, 25 parts of Perilla leaves, 15 parts of Costus root, and 15 parts of Cyperus rotundus.

[0008] The Chinese medicinal extract is prepared from the following Chinese medicinal components: 20 parts of Atractylodes macrocephala, 35 parts of Chinese yam, 18 parts of Amomum villosum, 25 parts of Coix seeds, 12 parts of Bupleurum, 30 parts of Scutellaria baicalensis, 15 parts of Artemisia capillaris, 30 parts of Polygonum cuspidatum, 15 parts of Pinellia ternata, 30 parts of Tangerine peel, 18 parts of Arisaema, 25 parts of Perilla seeds, 20 parts of Rhubarb, 16 parts of Areca catechu, 20 parts of Cassia seeds, 25 parts of Prunus mume seeds, 12 parts of Magnolia officinalis, 30 parts of Perilla leaves, 10 parts of Costus root, and 18 parts of Cyperus rotundus.

[0009] The Chinese medicinal extract is prepared from the following Chinese medicinal components: 30 parts of Atractylodes macrocephala, 25 parts of Dioscorea opposita, 22 parts of Amomum villosum, 15 parts of Coix seeds, 16 parts of Bupleurum chinense, 20 parts of Scutellaria baicalensis, 25 parts of Artemisia capillaris, 20 parts of Polygonum cuspidatum, 25 parts of Pinellia ternata, 20 parts of Tangerine peel, 22 parts of Arisaema consanguineum, 15 parts of Perilla seeds, 30 parts of Rhubarb, 12 parts of Areca catechu, 30 parts of Cassia seeds, 15 parts of Prunus mume seeds, 16 parts of Magnolia officinalis, 20 parts of Perilla leaves, 20 parts of Aucklandia lappa and 12 parts of Cyperus rotundus.

[0010] The composition that helps digestion function is an oral pharmaceutical preparation.

[0011] The composition that helps digestion function, the oral pharmaceutical preparation is one of tablets, granules, capsules, microcapsules, and mixtures.

[0012] The composition that helps digestion function and the method for preparing the oral pharmaceutical preparation include the following steps:

[0013] A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby;

[0014] B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound;

[0015] C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 10-12 times the dry weight of all the Chinese medicinal pieces, decoct 2-3 times, each time for 1.5-2.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.18-1.25 at 60-70°C;

[0016] D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.22-1.28 at 50-60°C;

[0017] E. The extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B are prepared into an oral pharmaceutical preparation directly through conventional procedures or by adding pharmaceutically acceptable excipients.

[0018] Application of the composition that helps digestive function in medicine for treating abdominal distension.

[0019] The composition that helps digestion is used in medicine for treating abdominal distension, which is a syndrome of internal obstruction of phlegm and dampness.

[0020] Atractylodes macrocephala is the dried rhizome of Atractylodes macrocephala Koidz., a plant of the Asteraceae family. It is harvested in winter when the lower leaves turn yellow and the upper leaves become brittle. The soil is removed and the leaves are dried in an oven or sun-dried. The fibrous roots are then removed. It enters the spleen and stomach meridians. Its properties are bitter, sweet, and warm. It strengthens the spleen and replenishes qi, dispels dampness and promotes diuresis, stops sweating, and stabilizes the fetus. It is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid retention, dizziness and palpitations, edema, spontaneous sweating, and restless fetuses. Atractylodes macrocephala strengthens the spleen, harmonizes the stomach, and stabilizes the fetus. It is used for spleen deficiency, poor appetite, diarrhea, loose stools, and restless fetuses.

[0021] Chinese yam is the dried rhizome of the Dioscorea plant, Dioscorea zingiberensis. Harvested between November and December, the root tip is removed, the soil is washed, the skin is scraped off with a bamboo knife, and sun-dried or oven-baked to create hairy yam. Select large, thick hairy yams, soak them thoroughly in clean water, then slightly heat them. Cover them with a quilt to keep them moist and airtight. Then, roll them onto a wooden board and shape them into a cylindrical shape. The ends are trimmed evenly, and the yam is sun-dried and polished to create polished yam. Its main functions and indications include strengthening the spleen, tonifying the lungs, strengthening the kidneys, and improving essence. It treats diarrhea due to spleen deficiency, chronic dysentery, consumptive cough, thirst, spermatorrhea, leucorrhea, and frequent urination. It nourishes the spleen and stomach, promotes fluid production and benefits the lungs, and tonifies the kidneys and astringes essence. It is used for spleen deficiency, poor appetite, chronic diarrhea, wheezing and coughing due to lung deficiency, spermatorrhea due to kidney deficiency, leucorrhea, frequent urination, and thirst due to deficiency-heat. Stir-fried Chinese yam with bran nourishes the spleen and stomach. It is used for spleen deficiency, poor appetite, diarrhea, loose stools, and excessive leucorrhea. ① "Shennong's Herbal Classic": Treats injuries, replenishes deficiency, eliminates cold and heat pathogenic qi, strengthens the middle and strengthens Qi, builds muscles, and improves hearing and vision with long-term use. ② "Bielu": Treats wind wandering in the head and face, dizziness caused by wind (also known as "head wind"), relieves gas, relieves low back pain, treats consumptive emaciation, replenishes the five internal organs, eliminates restlessness and fever, and strengthens the joints. ③ "Yao Xing Lun": Replenishes the five labors and seven injuries, dispels cold wind, relieves low back pain, calms the mind, replenishes heart Qi deficiency, and is used in combination with other herbs for patients with physical weakness. ④ "Shi Liao Ben Cao": Treats headaches and boosts Yin energy. ⑤ "Rihuazi Ben Cao": Supports the five internal organs, strengthens the bones and muscles, strengthens the mind and calms the spirit, and treats spermatorrhea and forgetfulness. ⑥ Zhu Zhenheng: Apply raw crushed herbs to dissipate swellings and hard toxins. ⑦ "Shang Han Yun Yao": Replenishes deficiency and clears heat. ⑧ "Compendium of Materia Medica": Strengthens kidney Qi, invigorates the spleen and stomach, stops diarrhea, resolves phlegm and saliva, and moisturizes the skin and fur.

[0022] Amomum villosum Lour., Amomum villosum Lour. var. xanthioides TLWu et Senjen, or Amomum longiligulare TLWu, all of the Zingiberaceae family. The fruit is harvested in summer and autumn when ripe and then sun-dried or low-temperature dried. It has a pungent flavor and warm properties. It enters the spleen, stomach, and kidney meridians. It has the effects of eliminating dampness and stimulating the appetite, warming the spleen and stopping diarrhea, regulating qi and stabilizing pregnancy. It is used to treat dampness and turbidity in the middle of the body, abdominal distension without hunger, spleen and stomach deficiency and cold, vomiting and diarrhea, nausea and vomiting during pregnancy, and fetal movement disorder.

[0023] Job's tears are the dried, mature kernels of the grass plant Coix lacryma-jobi L. var. mayuen (Roman.) Stapf. The plants are harvested in autumn when the fruits are ripe, sun-dried, and the fruits are beaten and sun-dried again. The shells, yellow-brown seed coats, and impurities are removed, and the kernels are collected. It has a sweet, mild, and slightly cold nature and is known to promote diuresis and reduce swelling, strengthen the spleen and eliminate dampness, relax the muscles and relieve numbness, and clear away heat and pus. It is a commonly used diuretic and dampness-removing herb. Job's tears are also a beauty food; regular consumption can maintain a smooth and lustrous complexion, eliminate acne, freckles, age spots, pregnancy spots, and butterfly spots, and is effective for treating desquamation, acne, chapped skin, and rough skin.

[0024] Bupleurum is the dried root of the Umbelliferae plant Bupleurum chinense or Bupleurum angustifolia. It is harvested in spring and autumn, the stems, leaves, and mud removed, and then dried. Bupleurum chinense is a commonly used antipyretic. Also known as ground smoked vegetables, mountain vegetables, mushroom grass, and firewood, it is bitter and slightly cold in nature and enters the liver and gallbladder meridians. It has the effects of harmonizing the exterior and interior, soothing the liver, and promoting yang. It is used for colds, fevers, alternating chills and fever, malaria, liver depression and qi stagnation, chest and rib pain, rectal prolapse, uterine prolapse, and menstrual irregularities.

[0025] Scutellaria baicalensis is a perennial herbaceous plant of the genus Scutellaria in the family Lamiaceae. It has a thick, fleshy rhizome and firm, papery, lanceolate to linear-lanceolate leaves. Its inflorescences are terminal, forming racemes on the stems and branches. Its corolla is purple, purplish-red, or blue, with flat filaments, slender styles, annular discs, brown ovaries, and ovoid nutlets. Flowering and fruiting occur from July to September. Scutellaria baicalensis grows on sunny, grassy slopes at altitudes of 60 to 1,300 meters (1,700 to 2,000 meters). It is native to Heilongjiang, Liaoning, Inner Mongolia Autonomous Region, Hebei, Henan, Gansu, Shaanxi, Shanxi, Shandong, and Sichuan provinces, and can be cultivated in most provinces in northern China. Its root is used medicinally, with a bitter taste and cold properties. It has the effects of clearing heat and dampness, purging fire and detoxifying, stopping bleeding, and tonifying the fetus. It is mainly used to treat febrile diseases, upper respiratory tract infections, lung heat cough, damp-heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, fetal movement disorder, hypertension, carbuncle, furuncle, etc. The clinical antibacterial activity of Scutellaria baicalensis is better than that of Coptis chinensis, and it does not produce drug resistance.

[0026] Artemisia capillaris is the dried aerial part of Artemisia scoparza Waldst.et Kit. or Artemisia capillaris Thunb., a plant of the Asteraceae family. It is harvested in spring when the seedlings are 6 to 250 cm tall, or in autumn when the flower buds have grown and are just beginning to bloom. Impurities and old stems are removed, and the plant is sun-dried. Those harvested in spring are commonly known as "cotton artemisia," while those harvested in autumn are called "flower artemisia." It has a bitter and pungent flavor and a slightly cold nature. It enters the spleen, stomach, liver, and gallbladder meridians. It clears dampness and heat, promotes bile secretion, and reduces jaundice. It is used for jaundice, oliguria, damp-heat due to summer heat, and itchy eczema.

[0027] Polygonum cuspidatum is the dried rhizome and root of Polygonum cuspidatum Sieb.et Zucc., a plant of the Polygonaceae family. It is harvested in spring and autumn, the fibrous roots removed, washed, cut into short segments or thick slices while fresh, and sun-dried. It is found in Northwest, East, Central, South, and Southwest China. It has the effects of promoting diuresis and relieving jaundice, clearing heat and detoxifying, dispersing blood stasis and relieving pain, and relieving cough and resolving phlegm. It is used to treat damp-heat jaundice, stranguria, leucorrhea, rheumatic pain, carbuncles, burns caused by water or fire, amenorrhea, abdominal masses, sprains, and coughs caused by lung heat.

[0028] Pinellia ternata (Pinellia ternata) is the dried tuber of the Araceae plant, Pinellia ternata (Thunb.) Breit. It is harvested in summer and autumn, washed, the outer skin and fibrous roots removed, and sun-dried. It is found throughout Northeast China, North China, and the Yangtze River Basin. It has the effects of drying dampness and resolving phlegm, relieving adverse reactions and vomiting, and dissolving lumps and masses. It is used for damp phlegm, cold phlegm, cough, asthma, excessive phlegm, phlegm-induced dizziness and palpitations, dizziness due to wind-induced phlegm, headaches due to phlegm syncope, vomiting and nausea, chest and abdominal distension, and plum-pit-like qi. It can also be used externally to treat carbuncles, swellings, and phlegm nodules.

[0029] Tangerine peel is the dried, mature peel of the citrus fruit (Citrus reticulata Blanco) and its cultivated varieties. This medicinal herb is divided into "Chenpi" and "Guangchenpi." The ripe fruit is harvested, the peel removed, and then sun-dried or low-temperature dried. It has a bitter and pungent flavor and warm properties. It enters the lung and spleen meridians. It regulates qi and strengthens the spleen, dispels dampness, and resolves phlegm. It is used to treat abdominal distension, loss of appetite, vomiting, diarrhea, and cough with excessive phlegm.

[0030] Arisaema is the dried tuber of Arisaema erubescens (Wall.) Schott, Arisaema heterophyllum Bl., or Arisaema amurense Maxim., all members of the Araceae family. It is harvested in autumn and winter when the stems and leaves wither, the fibrous roots and outer bark removed, and then dried. Arisaema is distributed in Hebei, Henan, Guangxi Zhuang Autonomous Region, Shaanxi, Hubei, Sichuan, Guizhou, Yunnan, and Shanxi provinces. Arisaema heterophyllum is distributed in Heilongjiang, Jilin, Liaoning, Zhejiang, Jiangsu, Jiangxi, Hubei, Sichuan, and Shaanxi provinces. Arisaema amurense is distributed in Heilongjiang, Jilin, Liaoning, Hebei, Jiangxi, Hubei, and Sichuan provinces. Arisaema has the effect of dispersing nodules and reducing swelling; it is used externally to treat carbuncles and snake and insect bites. Arisaema has the effects of drying dampness and resolving phlegm, dispelling wind and stopping spasm, dispersing stagnation and reducing swelling; it is used for cough with stubborn phlegm, dizziness caused by wind phlegm, phlegm congestion caused by stroke, mouth and eye pain. Oblique, hemiplegia, epilepsy, convulsions, tetanus; used externally to treat carbuncle, snake and insect bites.

[0031] Perilla seeds are the fruit of Perilla frutescens (L.) Britt. and Perilla frutescens (L.) Britt. var. purpurascens (Hayata) HWLi, both of the Lamiaceae family. Perilla is widely cultivated throughout China. Wild Perilla is found in East China, South China, Southwest China, and provinces such as Hebei, Shanxi, Shaanxi, and Taiwan. It has the effects of lowering qi, eliminating phlegm, relieving asthma, and moistening the intestines. It is commonly used to treat phlegm-stagnation, qi stagnation, cough, asthma, and constipation caused by dryness of the intestines.

[0032] Rhubarb is the root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim. ex Balf., or Rheum officinale Baill. (all species in the Polygonaceae family). It has the effects of purging, clearing away heat and purging fire, cooling the blood and detoxifying, and promoting menstruation. It is primarily used to treat constipation caused by stagnation, vomiting and bleeding due to blood heat, red eyes and swollen throat, ulcers caused by heat toxins, burns and scalds, blood stasis, damp-heat dysentery, jaundice, and stranguria.

[0033] Betel nut is the dried mature seed of Areca catechu L., a plant in the palm family. The mature fruit is harvested from late spring to early autumn, boiled, dried, the peel removed, and the seeds removed and dried. It has a bitter, pungent, and warming flavor. It enters the stomach and large intestine meridians. It kills insects, eliminates stagnation, promotes qi circulation, promotes diuresis, and prevents malaria. It is used to treat tapeworms, ascariasis, and fasciolitis, abdominal pain caused by worm accumulation, dysentery caused by stagnation, tenesmus, edema, beriberi, and malaria.

[0034] Cassia seeds are the dried, mature seeds of Senna obtusifolia (L.) HSIrwin & Barneby or Senna tora (L.) Roxb., both of the Leguminosae family. They are slightly rhombus-shaped or short cylindrical, with parallel, slanted ends. Their surface is greenish-brown or dark brown, smooth, and shiny. One end is relatively flat, while the other is obliquely pointed. There is a raised ridge on each dorsal and ventral surface, with a symmetrical, lighter-colored linear groove on either side of the ridge. They are hard and not easily broken. They have a faint odor and a slightly bitter taste. Stir-fried Cassia seeds resemble Cassia seeds, are slightly bulging, and have a greenish-brown or dark brown surface with occasional burnt spots. They have a slight aroma. Cassia seeds are widely distributed in China, found in most parts of the country, both in the wild and cultivated. They are primarily produced in Anhui, Jiangsu, Guangxi, Sichuan, Zhejiang, and Guangdong provinces. Cassia seed is a commonly used medicinal material in clinical practice. It has the functions of clearing away heat, improving eyesight, moistening the intestines and promoting bowel movements. It is mainly used to treat eye diseases, constipation, hypertension, hyperlipidemia and diabetes.

[0035] Prunus mume kernel is the seed kernel of Prunus mume, Prunus ovata, Prunus elata, and Prunus longifolia, all members of the Rosaceae family. It's also known as Prunus mume (Yi Xin Fang), Prunus mume kernel (Zhenzhu Nang), Prunus mume kernel meat (Ya Zao Xue), and Prunus mume kernel (National Compendium of Chinese Herbal Medicine). The original plant, Prunus mume, is also known as Changdi (Er Ya), Baidi (Shuowen), Jue Li (Ben Jing), Que Li, Che Xia Li (Wu Pu's Materia Medica), Shan Li, Jue Mei (Guang Ya), Que Mei (Bencao Jing Ji Zhu), Di Li, Xiang Chenopodium album (Yiannan Materia Medica), Yang Li, Chuan Xin Mei (Botanical Names and Illustrations); Prunus mume is also known as Shan Cherry and Chidi (Er Ya Yi Shu); Prunus longifolia is also known as Changpi Almond (Chinese Fruit Tree Taxonomy). Prunus mume kernel is harvested in summer and autumn and sun-dried. It is mild in nature, bitter and sweet in taste, and has the effects of moistening the lungs and lubricating the intestines, lowering qi and promoting diuresis. It can treat symptoms such as large intestinal qi stagnation, dryness and obstruction, difficulty urinating, abdominal edema, limb edema, and athlete's foot.

[0036] Magnolia officinalis (Magnolia officinalis Rehd. et Wils.) or Magnolia offinalis Rehd. et Wils. var. biloba Rehd. et Wils. (Magnolia officinalis Rehd. et Wils.) is a plant of the Magnoliaceae family. It is peeled between April and June, and the root and branch barks are directly dried in the shade. The bark is briefly boiled in boiling water and then piled in a damp, cool place to "sweat" until the inner surface turns purple-brown or tan. It is then steamed to soften, removed, rolled into a tube, and dried. It has a bitter and pungent flavor and is warm in nature. It enters the spleen, stomach, lung, and large intestine meridians. It dries dampness, eliminates phlegm, and relieves qi stagnation. It is used for dampness stagnation, abdominal distension and vomiting and diarrhea, food stagnation and qi stagnation, abdominal distension and constipation, and cough and wheezing caused by phlegm and fluid retention.

[0037] Perilla leaves are an annual, upright herb in the Lamiaceae family, Pyrgophora tribe, Dicotyledons, growing from July to August in southern China and from August to September in northern China. The stems are 0.3-2 meters tall, green or purple, obtusely quadrangular, with four grooves, and densely covered with long, soft hairs. Perilla and wild perilla have small, soft branches with leaves. They are warm in nature and pungent in flavor. They dispel cold, promote qi circulation, and relieve fullness, and can detoxify crab toxicity. They are primarily used to treat colds caused by wind and cold, as well as chest and abdominal distension, nausea, and vomiting due to spleen and stomach qi stagnation.

[0038] Costus root is the dried root of Aucklandia lappa Decne. (Asteraceae). It is harvested in autumn and winter, cleaned of mud and fibrous roots, and cut into sections. Larger ones are then split longitudinally into petals. After drying, the rough bark is removed. It has a pungent, bitter, and warming flavor. It enters the spleen, stomach, large intestine, triple burner, and gallbladder meridians. It promotes qi circulation, relieves pain, strengthens the spleen, and aids digestion. It is used to treat chest, flank, and abdominal distension and pain, heaviness after diarrhea, indigestion, and loss of appetite. Simmering costus root strengthens the intestines and relieves diarrhea. It is used for abdominal pain caused by diarrhea.

[0039] Cyperus rotundus is the dried rhizome of Cyperus serrata, a plant of the Cyperaceae family. It is harvested in autumn, scorched to remove the hair, briefly boiled in boiling water or steamed thoroughly before sun-drying, or directly sun-dried after scorching. It has a pungent, slightly bitter, slightly sweet, and neutral flavor. It enters the Liver, Spleen, and Triple Burner meridians. It soothes liver qi stagnation, relieves depression, regulates qi and relieves fullness, regulates menstruation, and relieves pain. It is used for liver qi stagnation, chest and flank pain, hernia pain, breast tenderness, spleen and stomach qi stagnation, abdominal distension and pain, menstrual irregularities, amenorrhea, and dysmenorrhea.

[0040] Digestive dysfunction is called "piman" in traditional Chinese medicine theory. Common syndrome classifications usually include liver-stomach disharmony, spleen-stomach damp-heat, phlegm-damp internal obstruction, food stagnation, and spleen-stomach deficiency. 1. Liver-stomach disharmony: chest and abdominal distension, flank and abdomen distension, depression or irritability, occasional sighing, heatiness, poor appetite, pale red tongue, thin white tongue coating, stringy or stringy pulse; 2. Spleen-stomach damp-heat: stomach fullness, dry mouth without desire to drink, bitter taste in the mouth, poor appetite, nausea and vomiting, heavy body and drowsiness, sticky and uncomfortable stools, short and yellow urine, red tongue, yellow and greasy tongue coating, slippery and rapid pulse; 3. Phlegm-damp internal obstruction: chest and abdominal distension, fullness and discomfort, nausea and vomiting, excessive phlegm or uncomfortable coughing up, bland mouth without thirst or spitting of clear saliva, headache Feeling heavy as if wrapped, limbs are tired, pale red tongue, thick and greasy coating, slippery or stringy and slippery pulse; 4. Food stagnation syndrome: chest and abdominal distension and discomfort after eating, warm and sour taste in the mouth, loss of appetite, or nausea and vomiting, the vomitus is food stagnation in the stomach, pale red tongue, thick and greasy coating, slippery pulse; 5. Spleen and stomach deficiency syndrome: chest and abdominal distension and discomfort, the condition is sometimes severe and sometimes mild, no appetite when hungry, likes heat and likes pressure, tiredness and laziness, shortness of breath and fatigue, loose stools, pale tongue, enlarged tongue or with teeth marks, thin white tongue coating, deep and thin pulse or weak pulse.

[0041] Phlegm-dampness obstruction is the most common. Pathogenesis analysis: Excessive phlegm-dampness in the body, either due to excessive diet (e.g., excessive consumption of rich, sweet, roasted foods, alcoholic beverages, or heavy flavors), fatigue, or anxiety, leads to the spleen's inability to transport and transform nutrients, and the stomach's inability to descend properly, causing phlegm-dampness to accumulate and become a problem. This manifests as chest and abdominal distension, fullness, and discomfort. Phlegm-dampness obstructs the rise and fall of clear oil, preventing the ascending of clear yang, and causing turbid qi to rise, obscuring the clear air. This can cause dizziness, chest tightness without hunger, and nausea and vomiting. Furthermore, due to the heavy nature of dampness, there is heaviness and fatigue. A turbid and greasy tongue coating and a slippery pulse are all signs of phlegm-dampness. Symptoms: chest and abdominal distension, fullness, and discomfort, dizziness, chest tightness without hunger, nausea and vomiting, heaviness and fatigue, or a difficult cough with sputum and yellow, sticky urine. A turbid and greasy tongue coating and a slippery pulse are all signs of phlegm-dampness.

[0042] The therapeutic mechanism of the present invention is as follows: 1. Phlegm-dampness internal obstruction, caused by phlegm-dampness lingering in the middle of the body, blocks the normal physiological functions of the spleen and stomach. Phlegm-dampness refers to an imbalance in the body's water metabolism, and internal obstruction refers to the location where phlegm-dampness resides, primarily the spleen and stomach. Typical manifestations of phlegm-dampness internal obstruction include dizziness, headache, stomach distension and discomfort, loss of appetite, vomiting, fatigue, and weakness. When phlegm-dampness obstructs the spleen and stomach, their normal physiological functions are impaired, preventing the spleen from transporting essence throughout the body, leading to feelings of fatigue and weakness. Impaired digestion of the spleen and stomach results in symptoms such as loss of appetite and abdominal distension. Therefore, the first step is to eliminate dampness and strengthen the spleen. 2. Because the gallbladder stores essence and fluids, harbors fire, and is responsible for ascending and regulating qi, gallbladder dysfunction, impaired essence and fluid flow, and impaired warmth in the middle earth, leading to imbalanced qi flow, can result in wood dominating the earth, wood failing to disperse the earth, and fire failing to warm the earth. This can affect the gallbladder's ability to assist in digestion and transportation, leading to intestinal flora disturbances and insufficient or impaired gastrointestinal motility. Therefore, liver-soothing and gallbladder-promoting methods are necessary. 3. Damp-heat accumulates in the middle jiao spleen, stomach and liver and gallbladder. Dampness is a heavy, turbid and sticky evil. Phlegm is produced by the spleen's inability to move properly. Phlegm-dampness blocks the qi mechanism and combines with heat evil, resulting in damp heat, phlegm and turbidity. Heat is difficult to resolve due to dampness obstruction. Phlegm-dampness blocks the spleen yang. Phlegm-dampness is steamed by heat and further damages the yang qi. The present invention adopts a method of resolving phlegm on the basis of removing dampness. 4. Diet damages the spleen and stomach, causing obstruction of stomach qi and spleen qi's inability to move properly, resulting in abnormal functions of cooking and rotting food and transporting and transforming the essence, causing food stagnation and accumulation without dispersion. Therefore, there is chest and abdominal fullness, discomfort and discomfort, and the hand cannot press; the stomach loses its harmony and descending function, and the oil and gas of the stomach go up against the flow, resulting in nausea and vomiting, warm rot and acid regurgitation; food stagnation and long-term depression turn into heat, and stomach heat can digest food and make people hungry, and can also consume and burn the body fluids of the large intestine, resulting in being able to eat but constipated, so it is necessary to remove stagnation and relieve constipation. 5. The present invention also adopts ascending and descending combinations, promoting descent by ascending and ascending by descending, which is beneficial to the circulation of Qi. This is reflected in the combination of bitter and pungent. Bitterness can descend and drain and harmonize Yang, while pungentness can open and combine Yin. The two are used together to promote Yang and disperse stagnation, circulate Qi, and thus restore the function of the ascending and descending pivot of the middle burner.

[0043] In summary, the present invention adopts Atractylodes macrocephala, Chinese yam, Amomum villosum, Coix seed to dry dampness and strengthen the spleen, Bupleurum, Scutellaria baicalensis, Artemisia capillaris, Polygonum cuspidatum to soothe the liver and promote bile secretion, which are all monarch drugs. Among them, Bupleurum and Scutellaria baicalensis are first used to treat the gallbladder, Bupleurum is light and clear and ascends to disperse, soothe the Shaoyang meridian, regulate the gallbladder qi, and penetrate the stagnant heat, Scutellaria baicalensis is bitter and cold and can directly break the gallbladder viscera, Artemisia capillaris clears dampness and heat, promotes bile secretion and reduces jaundice, Polygonum cuspidatum clears dampness and reduces jaundice, clears heat and detoxifies, disperses blood stasis and relieves pain, relieves cough and resolves phlegm, and has a great effect on the treatment of phlegm. Huang, Areca nut, Cassia seed, and Prunus mume seed are ministerial herbs, relieving stagnation and relieving constipation. Pinellia ternata, Tangerine peel, Arisaema consanguineum, and Perilla seed regulate Qi and resolve phlegm, drying dampness and resolving phlegm, and are adjuvant herbs. Magnolia bark, Perilla leaf, Aucklandia lappa, and Cyperus rotundus regulate Qi and eliminate stagnation, relieve fullness and soothe the chest, regulate the ascending and descending Qi, relieve the exterior and interior, and relieve bloating. The pungent Pinellia ternata can promote the flow of Qi, dispel cold and dampness, harmonize the stomach, and reduce adverse reactions. Bitter herbs such as Scutellaria baicalensis and Citrus aurantium can purge heat and harmonize the stomach, eliminating bloating and distension. Taken together, they have the bitter and pungent effect of promoting the flow of Qi, harmonizing cold and heat, activating the Qi, and eliminating bloating and distension. The whole prescription contains Atractylodes macrocephala, Chinese yam, Amomum villosum, Coix seed, Bupleurum chinense, Scutellaria baicalensis, Artemisia capillaris, Polygonum cuspidatum, Pinellia ternata, Tangerine peel, Arisaema consanguineum, Perilla seed, Rhubarb, Areca catechu, Cassia seed, Prunus mume seed, Magnolia officinalis, Perilla leaf, Costus root, and Cyperus rotundus. It can dry dampness and strengthen the spleen, soothe the liver and promote bile secretion, relieve stagnation and promote bowel movements, regulate Qi and resolve phlegm, dry dampness and resolve phlegm, regulate Qi and eliminate stagnation, eliminate fullness and relieve chest tightness, regulate the rise and fall of Qi, relieve exterior and interior symptoms, and relieve abdominal distension. The combination of the two herbs complements each other and can treat fullness and distension.

[0044] Clinical studies have shown that Example 1 significantly increased the treatment efficacy compared to the control group. Comparison of TCM symptom scores before treatment showed that Example 1 significantly reduced upper abdominal pain and postprandial fullness in the control group after treatment (P < 0.05), demonstrating that the present invention is effective in treating phlegm-dampness internal obstruction syndrome-type fullness. DETAILED DESCRIPTION

[0045] Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiments are only used to illustrate the present invention and are not used in limiting the scope of the present invention.In addition, should be understood that after reading the content of the present invention record, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the application's appended claims equally.

[0046] Example 1:

[0047] Take 250g of Atractylodes macrocephala, 300g of Chinese yam, 200g of Amomum villosum, 200g of Coix seed, 140g of Bupleurum, 250g of Scutellaria baicalensis, 200g of Artemisia capillaris, 250g of Polygonum cuspidatum, 200g of Pinellia ternata, 250g of Tangerine peel, 200g of Arisaema, 200g of Perilla seed, 250g of Rhubarb, 140g of Areca catechu, 250g of Cassia seed, 200g of Prunus mume seed, 140g of Magnolia bark, 250g of Perilla leaf, 150g of Aucklandia root, and 150g of Cyperus rotundus. The preparation method comprises the following steps:

[0048] A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby;

[0049] B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound;

[0050] C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 10 times the dry weight of all the Chinese medicinal pieces, decoct 3 times, each time for 1.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.18 at 70°C;

[0051] D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.22 at 60°C;

[0052] E. Take the extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B, add dextrin to prepare granules.

[0053] Example 2:

[0054] Take 200g of Atractylodes macrocephala, 350g of Chinese yam, 180g of Amomum villosum, 250g of Coix seed, 120g of Bupleurum, 300g of Scutellaria baicalensis, 150g of Artemisia capillaris, 300g of Polygonum cuspidatum, 150g of Pinellia ternata, 300g of Tangerine peel, 180g of Arisaema, 250g of Perilla seed, 200g of Rhubarb, 160g of Areca catechu, 200g of Cassia seed, 250g of Prunus mume seed, 120g of Magnolia officinalis, 300g of Perilla leaf, 100g of Aucklandia root, and 180g of Cyperus rotundus. The preparation method comprises the following steps:

[0055] A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby;

[0056] B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound;

[0057] C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 12 times the dry weight of all the Chinese medicinal pieces, decoct twice, each time for 2.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.25 at 60°C;

[0058] D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.28 at 50°C;

[0059] E. Take the extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B, add starch and prepare tablets.

[0060] Example 3:

[0061] Take 250g of Atractylodes macrocephala, 300g of Chinese yam, 200g of Amomum villosum, 200g of Coix seed, 140g of Bupleurum, 250g of Scutellaria baicalensis, 200g of Artemisia capillaris, 250g of Polygonum cuspidatum, 200g of Pinellia ternata, 250g of Tangerine peel, 200g of Arisaema, 200g of Perilla seed, 250g of Rhubarb, 140g of Areca catechu, 250g of Cassia seed, 200g of Prunus mume seed, 140g of Magnolia bark, 250g of Perilla leaf, 150g of Aucklandia root, and 150g of Cyperus rotundus. The preparation method comprises the following steps:

[0062] A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby;

[0063] B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound;

[0064] C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 10 times the dry weight of all the Chinese medicinal pieces, decoct 3 times, each time for 1.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.18 at 70°C;

[0065] D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.22 at 60°C;

[0066] E. Take the extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B, add microcrystalline cellulose and prepare capsules.

[0067] Example 4:

[0068] Take 300g of Atractylodes macrocephala, 250g of Chinese yam, 220g of Amomum villosum, 150g of Coix seed, 160g of Bupleurum, 200g of Scutellaria baicalensis, 250g of Artemisia capillaris, 200g of Polygonum cuspidatum, 250g of Pinellia ternata, 200g of Tangerine peel, 220g of Arisaema, 150g of Perilla seed, 300g of Rhubarb, 120g of Areca catechu, 300g of Cassia seed, 150g of Prunus mume seed, 160g of Magnolia officinalis, 200g of Perilla leaf, 200g of Aucklandia lappa, and 120g of Cyperus rotundus. The preparation method comprises the following steps:

[0069] A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby;

[0070] B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound;

[0071] C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 12 times the dry weight of all the Chinese medicinal pieces, decoct twice, each time for 2.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.25 at 60°C;

[0072] D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.28 at 50°C;

[0073] E. Take the extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B, add dextrin to prepare microcapsules.

[0074] Example 5:

[0075] Take 250g of Atractylodes macrocephala, 300g of Chinese yam, 200g of Amomum villosum, 200g of Coix seed, 140g of Bupleurum, 250g of Scutellaria baicalensis, 200g of Artemisia capillaris, 250g of Polygonum cuspidatum, 200g of Pinellia ternata, 250g of Tangerine peel, 200g of Arisaema, 200g of Perilla seed, 250g of Rhubarb, 140g of Areca catechu, 250g of Cassia seed, 200g of Prunus mume seed, 140g of Magnolia bark, 250g of Perilla leaf, 150g of Aucklandia root, and 150g of Cyperus rotundus. The preparation method comprises the following steps:

[0076] A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby;

[0077] B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound;

[0078] C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 10 times the dry weight of all the Chinese medicinal pieces, decoct 3 times, each time for 1.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.18 at 70°C;

[0079] D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.22 at 60°C;

[0080] E. Take the extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B, add purified water to prepare a mixture.

[0081] Example 6: Clinical study on the present invention in treating fullness and distension of phlegm-dampness syndrome

[0082] 1. Case selection: 100 patients with distension and fullness due to phlegm-dampness internal obstruction syndrome who were admitted to the company's cooperative outpatient department from October 2022 to May 2023 were selected as observation subjects and divided into groups according to the random sampling method. Among the 50 cases in the control group, there were 28 males and 22 females, aged 45-67 years, with a disease course of 2-8 years; among the 50 cases in the present invention group, there were 23 males and 27 females, aged 41-69 years, with a disease course of 2-11 years. Comparison of the research data of the two groups showed no significant difference (P>0.05).

[0083] 2. Case inclusion criteria: (1) All patients were found to meet the diagnostic criteria for fullness and distension due to phlegm-dampness internal obstruction syndrome in the “Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases”; (2) All patients had good communication and comprehension skills; (3) All patients were aware of the study and were willing to sign the consent form; (4) The study was approved by the hospital ethics committee.

[0084] Symptoms: Chest and epigastric distension, fullness and discomfort, dizziness, chest tightness without hunger, nausea and vomiting, heaviness and fatigue, or coughing up phlegm, yellow and sticky urine. Turbid and greasy tongue coating, slippery pulse.

[0085] 3. Method: The control group was treated with Xiangshapingweisan (produced by Yunnan Baiyao Group Co., Ltd.), twice a day, one bag at a time, 6 grams per bag, and taken continuously for 21 days. The present invention group was treated with the granules prepared by the method of Example 1 (daily prescription is: take Atractylodes macrocephala 25g, Rhizoma Dioscoreae 30g, Fructus Amomi 20g, Fructus Coicis 20g, Radix Bupleuri 14g, Radix Scutellariae 25g, Herba Artemisiae Scopariae 20g, Rhizoma Polygoni Cuspidati 25g, Rhizoma Pinelliae 20g, Pericarpium Citri Reticulatae 25g, Rhizoma Perillae 20g, Radix Et Rhizoma Rhei 25g, Semen Arecae 14g, Semen Cassiae 25g, Semen Pruni 20g, Cortex Magnoliae Officinalis 14g, Folium Perillae 25g, Radix Aucklandiae 15g, Rhizoma Cyperi 15g), twice a day, and taken continuously for 21 days.

[0086] 4. Diagnostic criteria: (1) Clinical efficacy evaluation: markedly effective: the main clinical symptoms have basically disappeared and the discomfort has improved; effective: the clinical symptoms have been greatly improved and there is no obvious discomfort; ineffective: discomfort and clinical symptoms are still present. Treatment efficacy = (markedly effective + effective) cases / number of cases in each group × 100%.

[0087] (2) TCM syndrome score assessment: The TCM syndrome scores of the two groups of patients were assessed before and after treatment. The scores were divided into two items, including upper abdominal pain and postprandial fullness. The severity was assessed as follows: 6 points: self-perceived symptoms were obvious, affecting work and daily life, and needed to be controlled by medication; 4 points: self-perceived symptoms were relatively obvious, but the patient was able to carry out normal work and maintain a healthy life; 2 points: symptoms were mild and needed careful observation; 0 points: no discomfort.

[0088] 5. Comparison of treatment effects between the two groups is shown in Tables 1 and 2.

[0089] Table 1 Comparison of treatment effects between the two groups of patients

[0090] Group Significantly effective efficient invalid Effectiveness (%) control group 15 22 23 74 Example 1 group 21 25 4 92

[0091] It shows that the treatment efficiency of Example 1 group is significantly higher than that of the control group.

[0092] Table 2 Comparison of TCM syndrome scores between the two groups before and after treatment

[0093]

[0094] The TCM symptom scores of the two groups were compared before treatment. The upper abdominal pain and postprandial fullness in the group 1 of Example 1 of the present invention were significantly reduced after treatment compared with the control group. The difference between the two groups was significant (P < 0.05), indicating that the present invention has a good effect in treating phlegm-dampness internal obstruction syndrome type fullness.

[0095] 6. model case: Zhang, 56 years old, female, is diagnosed as phlegm-dampness internal obstruction syndrome type fullness and distension through traditional Chinese medicine, symptom: chest and abdominal distension, fullness and discomfort, dizziness, chest tightness without hunger, nausea and vomiting, heaviness and fatigue, or coughing up phlegm and discomfort, yellow and astringent urine. Turbid and greasy tongue coating, slippery pulse. Give the granules prepared by embodiment 1 method (prescription every day is: take Atractylodes macrocephala 25g, Dioscorea batatas 30g, Fructus Amomi 20g, Fructus Coicis 20g, Radix Bupleuri 14g, Radix Scutellariae 25g, Herba Artemisiae Scopariae 20g, Rhizoma Polygoni Cuspidati 25g, Rhizoma Pinelliae 20g, Pericarpium Citri Reticulatae 25g, Cistanche deserticola 20g, Fructus Perillae 20g, Radix Et Rhizoma Rhei 25g, Areca catechu 14g, Semen Cassiae 25g, Semen Pruni 20g, Cortex Magnoliae Bark 14g, Folium Perillae 25g, Radix Aucklandiae 15g, Rhizoma Cyperi 15g), twice on the one. After taking it for 21 days, the upper abdominal pain and postprandial fullness basically disappeared, and the patient felt good and had no discomfort, which was confirmed to be significantly effective.

[0096] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. Use of a composition that helps digestion in the preparation of a drug for treating abdominal distension, characterized in that: The composition for facilitating digestive function is prepared from the following Chinese medicinal components by weight: 20-30 parts of Atractylodes macrocephala, 25-35 parts of Chinese yam, 18-22 parts of Amomum villosum, 15-25 parts of Coix seeds, 12-16 parts of Bupleurum chinense, 20-30 parts of Scutellaria baicalensis, 15-25 parts of Artemisia capillaris, 20-30 parts of Polygonum cuspidatum, 15-25 parts of Pinellia ternata, 20-30 parts of Tangerine peel, 18-22 parts of Arisaema consanguineum, 15-25 parts of Perilla seeds, 20-30 parts of Rhubarb, 12-16 parts of Areca catechu, 20-30 parts of Cassia seeds, 15-25 parts of Prunus mume seeds, 12-16 parts of Magnolia officinalis, 20-30 parts of Perilla leaves, 10-20 parts of Aucklandia lappa, and 12-18 parts of Cyperus rotundus. The composition is an oral pharmaceutical preparation, and the preparation method of the oral pharmaceutical preparation comprises the following steps: A, Amomum villosum, Bupleurum root, Artemisia capillaris, Tangerine peel, Perilla leaf, Aucklandia root and Cyperus rhizome are mixed to extract volatile oil, and the distilled medicinal residues and the distilled aqueous solution are used for standby; B. Take the volatile oil obtained in step A and add β-cyclodextrin to form an inclusion compound; C. Mix the distilled medicinal residues obtained in step A with other medicinal pieces, add the distilled aqueous solution obtained in step A, add water to 10-12 times the dry weight of all the Chinese medicinal pieces, decoct 2-3 times, each time for 1.5-2.5 hours, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.18-1.25 at 60-70°C; D. Add 5 times the volume of 65% ethanol to the extract obtained in step C, mix well, let it stand for 24 hours, and take the supernatant and concentrate it to an extract with a relative density of 1.22-1.28 at 50-60°C; E. The extract obtained in step D and the β-cyclodextrin inclusion compound obtained in step B are prepared into an oral pharmaceutical preparation directly through conventional procedures or by adding pharmaceutically acceptable excipients.

2. Use of a composition for improving digestive function according to claim 1 in the preparation of a drug for treating abdominal distension, characterized in that: The composition for facilitating digestive function is prepared from the following Chinese medicinal ingredients by weight: 25 parts of Atractylodes macrocephala, 30 parts of Chinese yam, 20 parts of Amomum villosum, 20 parts of Coix seeds, 14 parts of Bupleurum chinense, 25 parts of Scutellaria baicalensis, 20 parts of Artemisia capillaris, 25 parts of Polygonum cuspidatum, 20 parts of Pinellia ternata, 25 parts of Tangerine peel, 20 parts of Arisaema consanguineum, 20 parts of Perilla seeds, 25 parts of Rhubarb, 14 parts of Areca catechu, 25 parts of Cassia seeds, 20 parts of Prunus mume seeds, 14 parts of Magnolia officinalis, 25 parts of Perilla leaves, 15 parts of Costus root, and 15 parts of Cyperus rotundus.

3. Use of the composition for improving digestive function according to claim 1 in the preparation of a drug for treating abdominal distension, characterized in that: The oral pharmaceutical preparation is one of tablets, granules, capsules and mixtures.

4. Use of a composition for improving digestive function according to claim 1 in preparing a drug for treating abdominal distension, characterized in that: Piman belongs to the syndrome of internal obstruction of phlegm and dampness.

Images