Nutrient solution preparation method, device, computer readable medium and nutrient solution

During the preparation of the nutrient solution, mineral salts and maltodextrin are mixed and homogenized and sterilized, the problem of reducing the stability of the nutrient solution after increasing the minerals is solved, and the stability and nutrition of the nutrient solution are achieved Effective absorption and utilization of ingredients.

CN118177379BActive Publication Date: 2025-02-18FRESENIUS KABI SSPC PHARM CO LTD
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Patent Information

Application Number
CN202410176708.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-02-07
Publication Date
2025-02-18
Estimated Expiration
2044-02-07

AI Technical Summary

Technical Problem

While increasing the minerals in the nutrient solution, it is easy to cause the physical and chemical stability of the nutrient solution to decrease, precipitation and stratification, which affects compliance, taste and appearance, as well as the absorption and utilization of nutrients.

Method used

By obtaining materials and stirring oil, including mineral salts and maltodextrin, the preparation and treatment are carried out to ensure the stability of the nutrient solution.

Benefits of technology

On the basis of increasing minerals, maintain the physical and chemical stability of nutrient solution, improve compliance, taste and appearance, and promote the absorption and utilization of nutrients.

✦ Generated by Eureka AI based on patent content.

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Abstract

The embodiments of the present disclosure disclose a method, an apparatus, a computer-readable medium, and a nutrient solution for preparing a nutrient solution. A specific implementation of the method includes: obtaining materials and stirred oil, wherein the materials include mineral salts and maltodextrin; mixing the mineral salts and maltodextrin in the materials to obtain a mixed material; formulating the mixed material and the stirred oil to obtain a formulated nutrient solution; homogenizing and sterilizing the formulated nutrient solution to obtain a nutrient solution. The nutrient solution prepared by this implementation can maintain the physical and chemical stability of the nutrient solution on the basis of adding minerals, thereby improving the compliance, taste, and appearance of the nutrient solution, and maintaining the absorption and utilization of the nutrients in the nutrient solution.
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Description

Technical Field

[0001] Embodiments of the present disclosure relate to the technical field of nutrient solution preparation, and in particular to a nutrient solution preparation method, an apparatus, a computer-readable medium, and a nutrient solution. Background Art

[0002] Complete nutrient solution for special medical purposes is an emulsion system containing protein, carbohydrates, fat, vitamins and minerals, etc., which is used to supplement the nutrients needed by the body and maintain the body's normal metabolism. At present, different regions have different requirements for the content of nutrients in nutrient solution, and some regions require increasing the content of nutrients (such as minerals) in nutrient solution.

[0003] However, when increasing the nutrients in the nutrient solution, the following technical problems often occur: the increase of minerals in the nutrients will cause the physical and chemical stability of the nutrient solution to decrease, which can easily lead to precipitation and fat layer in the nutrient solution, resulting in poor compliance, taste and appearance of the nutrient solution, and affecting the absorption and utilization of the nutrients in the nutrient solution.

[0004] The above information disclosed in this Background section is only for enhancement of understanding of the background of the inventive concept and therefore it may contain information that does not form the prior art that is already known in this country to a person of ordinary skill in the art. Summary of the invention

[0005] The content of this disclosure is used to introduce concepts in a brief form, which will be described in detail in the detailed implementation section below. The content of this disclosure is not intended to identify the key features or essential features of the technical solution claimed for protection, nor is it intended to limit the scope of the technical solution claimed for protection.

[0006] Some embodiments of the present disclosure propose a nutrient solution preparation method, a nutrient solution preparation device, and a computer-readable medium to solve the technical problems mentioned in the above background technology section.

[0007] In a first aspect, some embodiments of the present disclosure provide a method for preparing a nutrient solution, the method comprising: obtaining materials and stirred oil, wherein the materials include mineral salts and maltodextrin; mixing the mineral salts and maltodextrin in the materials to obtain a mixed material; preparing the mixed material and the stirred oil to obtain a prepared nutrient solution; and homogenizing and sterilizing the prepared nutrient solution to obtain a nutrient solution.

[0008] Optionally, the above-mentioned obtaining of materials and stirred oil includes: quantitatively injecting at least one oil and emulsifier into a hot oil tank through a pipeline for raw and auxiliary materials; heating and stirring the injected at least one oil and emulsifier through the above-mentioned hot oil tank to obtain the stirred oil.

[0009] Optionally, the above-mentioned material also includes a compound food additive; and the above-mentioned mixing of the mineral salt and maltodextrin in the above-mentioned material to obtain a mixed material includes: mixing the mineral salt, maltodextrin and compound food additive in the above-mentioned material by a mixer to obtain a mixed material.

[0010] Optionally, the above-mentioned materials also include white sugar and protein powder; and the above-mentioned mixed materials and the above-mentioned stirred oil are prepared to obtain a prepared nutrient solution, including: adding reverse osmosis water into a mixing tank; starting the online mixer and stirring paddle included in the above-mentioned mixing tank; during the stirring process, adding stabilizer, white sugar, maltodextrin and protein powder, stirred oil, mixed materials and flavors into the above-mentioned mixing tank in sequence; cooling the stirred materials in the above-mentioned mixing tank to obtain a prepared nutrient solution.

[0011] Optionally, the above-mentioned homogenization and sterilization treatment of the prepared nutrient solution to obtain the nutrient solution includes: pre-homogenization treatment of the prepared nutrient solution by a preset pre-homogenization pressure and a preset pre-homogenization temperature to obtain a pre-homogenized nutrient solution; sterilization treatment of the pre-homogenized nutrient solution to obtain a sterilized nutrient solution; post-homogenization treatment of the sterilized nutrient solution by a preset post-homogenization pressure and a preset post-homogenization temperature to obtain the nutrient solution.

[0012] Optionally, the method further includes: aseptically filling the nutrient solution to obtain a filled nutrient solution; nitrogen-filling and film-sealing the filled nutrient solution to obtain a sealed nutrient solution; leak detecting the sealed nutrient solution to obtain a leak detection result; capping the sealed nutrient solution based on the leak detection result to obtain a capped nutrient solution; detecting foreign matter in the capped nutrient solution to obtain a foreign matter detection result; and packaging the capped nutrient solution based on the foreign matter detection result to obtain a packaged nutrient solution.

[0013] In the second aspect, some embodiments of the present disclosure provide a nutrient solution preparation device, comprising: one or more processors; a storage device on which one or more programs are stored, a mixing device for performing a mixing operation; a preparation device for performing a preparation operation; a homogenization and sterilization device for performing a homogenization and sterilization operation; when one or more programs are executed by one or more processors, the one or more processors implement the method described in any implementation method of the above-mentioned first aspect.

[0014] In a third aspect, some embodiments of the present disclosure provide a computer-readable medium having a computer program stored thereon, wherein when the program is executed by a processor, the method described in any implementation manner of the above-mentioned first aspect is implemented.

[0015] In a fourth aspect, some embodiments of the present disclosure provide a nutrient solution, wherein the nutrient solution is prepared by the method described in any implementation of the first aspect, and comprises the following raw materials in parts by weight: 20% to 90% water, 10% to 20% maltodextrin, 5% to 6% hydrolyzed whey protein powder, 3% to 4% white sugar, 1% to 2% medium chain triglycerides, 1% to 2% vegetable oil, 0.1% to 1% dipotassium hydrogen phosphate, 0.1% to 1% calcium citrate, 0.1% to 1% sodium chloride, and 0.1% to 1% vitamin compound food additives. 1%~1%, stabilizer 0.01%~0.11%, choline chloride 0.01%~0.1%, edible flavor 0.1%~1%, magnesium oxide 0.01%~0.1%, emulsifier 0.01%~0.1%, trace element compound food additives 0.1%~1%, calcium chloride 0.01%~0.1%, compound food additives including chromium chloride, maltodextrin and niacinamide 0.001%~0.01% and compound food additives including sodium molybdate, maltodextrin and niacinamide 0.0002%~0.01%.

[0016] The above-mentioned embodiments of the present disclosure have the following beneficial effects: the nutrient solution prepared by the nutrient solution preparation method of some embodiments of the present disclosure can still maintain the physical and chemical stability of the nutrient solution on the basis of adding minerals, thereby improving the compliance, taste and appearance of the nutrient solution, and maintaining the absorption and utilization of the nutrients in the nutrient solution. Specifically, the reasons that affect the absorption and utilization of the nutrients in the nutrient solution are: the increase of minerals in the nutrients, the increase of metal ion concentration, the emulsion particles in the nutrient solution are more inclined to aggregate with each other, the thermal stability is reduced, stratification and precipitation occur, the physical stability is poor, and then the chemical stability is poor, resulting in poor compliance, taste and appearance of the nutrient solution. Based on this, the nutrient solution preparation method of some embodiments of the present disclosure, first, obtain materials and stirred oil. Among them, the above-mentioned materials include mineral salts and maltodextrin. Thus, the raw materials for preparing the nutrient solution can be obtained for subsequent preparation. Then, the mineral salts and maltodextrin in the above-mentioned materials are mixed to obtain the mixed material. Thus, after the mineral salts are mixed and diluted by maltodextrin, the subsequent local mineral concentration is avoided to be too high, causing protein denaturation. Afterwards, the mixed material and the stirred oil are formulated to obtain a formulated nutrient solution. Thus, the material and the oil can be formulated to obtain a formulated nutrient solution. Finally, the formulated nutrient solution is homogenized and sterilized to obtain a nutrient solution. Thus, the formulated nutrient solution can be homogenized and sterilized, and the bacteria in the nutrient solution can be reduced by the sterilization treatment. The fluidity of the nutrient solution can be improved by the homogenization treatment, and the stability of the nutrient solution can be increased, so that the nutrients in the nutrient solution are more evenly distributed. Therefore, the nutrient solution prepared by the nutrient solution preparation method of some embodiments of the present disclosure can still maintain the physical and chemical stability of the nutrient solution on the basis of adding minerals, thereby improving the compliance, taste and appearance of the nutrient solution, and maintaining the absorption and utilization of the nutrients in the nutrient solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. Throughout the accompanying drawings, the same or similar reference numerals represent the same or similar elements. It should be understood that the drawings are schematic and that components and elements are not necessarily drawn to scale.

[0018] Figure 1 is a flow chart of some embodiments of the method for preparing a nutrient solution according to the present disclosure;

[0019] Figure 2 It is a schematic diagram of the structure of various electronic components included in the nutrient solution preparation device suitable for implementing some embodiments of the present disclosure. DETAILED DESCRIPTION

[0020] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to provide a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0021] It should also be noted that, for ease of description, only the parts related to the invention are shown in the drawings. In the absence of conflict, the embodiments and features in the embodiments of the present disclosure can be combined with each other.

[0022] It should be noted that the concepts such as "first" and "second" mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not used to limit the order or interdependence of the functions performed by these devices, modules or units.

[0023] It should be noted that the modifications of "one" and "plurality" mentioned in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that unless otherwise clearly indicated in the context, it should be understood as "one or more".

[0024] The names of the messages or information exchanged between multiple devices in the embodiments of the present disclosure are only used for illustrative purposes and are not used to limit the scope of these messages or information.

[0025] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0026] refer to Figure 1 , shows a process 100 of some embodiments of the method for preparing a nutrient solution according to the present disclosure. The method for preparing a nutrient solution comprises the following steps:

[0027] Step 101, obtaining materials and stirred oil.

[0028] In some embodiments, the execution entity of the nutrient solution preparation method (for example, nutrient solution preparation equipment, which may include: process robots, hot oil tanks, mixers, mixing tanks, filters and other equipment) can obtain materials and stirred oil. The above-mentioned materials can be various materials used to prepare nutrient solutions. Among them, the above-mentioned materials may include mineral salts and maltodextrin. Here, there is no limitation on the specific material types and formula amounts included in the materials. Users can adjust according to specific nutrient solution parameters. In practice, the above-mentioned execution entity can obtain materials from the material temporary storage area.

[0029] In some optional implementations of some embodiments, the execution subject may obtain the material and the stirred oil by performing the following steps to obtain the mixed material:

[0030] The first step is to quantitatively inject at least one oil and an emulsifier into the hot oil tank through a pipeline. Among them, the at least one oil includes medium-chain triglycerides and vegetable oils, and the vegetable oils include low-erucic acid rapeseed oil and safflower oil. The emulsifier can be citric acid fatty acid glyceride. In practice, the above-mentioned execution entity can quantitatively add the oil required for the formula from the medium-chain triglyceride oil tank and the vegetable oil tank to the hot oil tank through a pipeline, and then add citric acid fatty acid glyceride to the hot oil tank. Medium-chain triglycerides are not easy to trigger appetite, and their energy density is lower than that of long-chain triglycerides. They are less deposited in adipose tissue and can be quickly digested and oxidized. A diet that replaces part of the long-chain triglycerides with medium-chain triglycerides is not easy to cause weight gain in healthy men. And medium-chain triglycerides can also be used to treat patients with fat malabsorption. In the field of sports nutrition, medium-chain triglycerides are used as an energy substance. The synergistic supply of medium-chain triglycerides and carbohydrates can prolong the energy release time and effectively maintain the energy needs of athletes during long-term exercise. The vegetable oil in the above-mentioned vegetable oil tank can include low-erucic acid rapeseed oil and safflower oil. Rapeseed oil with low erucic acid is beneficial to bile function, and the digestion and absorption rate of rapeseed oil by the human body is relatively high. Compared with other oils, the composition of rapeseed oil with low erucic acid is very low in saturated fatty acids, high in oleic acid, and intermediate in linoleic acid and linolenic acid. Eating rapeseed oil can reduce blood cholesterol levels, prevent and treat cardiovascular diseases, etc. Safflower seed oil is rich in vitamin E and sterols, has high nutritional value, and has certain effects on lowering blood pressure, anti-aging, anti-infertility and lowering blood cholesterol. The above-mentioned emulsifier can be a class of substances that form a stable emulsion of a mixed liquid of two or more immiscible components. For example, the above-mentioned emulsifier can be citric acid fatty acid glyceride. By adding the above-mentioned emulsifier, an oil-in-water emulsion can be formed, so that protein and fat are better combined to form a homogeneous emulsion, and fat and protein are prevented from separating to form a fat layer.

[0031] The second step is to heat and stir the injected at least one oil and emulsifier through the hot oil tank to obtain the stirred oil. In practice, the execution subject can heat and stir the injected at least one oil to obtain the stirred oil. The heating temperature can be greater than 80°C.

[0032] Step 102, mixing the mineral salt and maltodextrin in the material to obtain a mixed material.

[0033] In some embodiments, the execution entity may mix the mineral salt and maltodextrin in the material to obtain a mixed material.

[0034] In some optional implementations of some embodiments, the above-mentioned materials may also include compound food additives. For example, considering that there are many types of vitamins in the formula of the nutrient solution and the formula amount is low. In order to simplify the procurement of raw materials and facilitate production, vitamins can be added in the form of compound food additives. The above-mentioned compound food additives may include vitamin compound food additives, trace element compound food additives, compound food additives including chromium chloride, maltodextrin and nicotinamide, and compound food additives including sodium molybdate, maltodextrin and nicotinamide. The above-mentioned vitamin compound food additives may be compound food additives composed of a variety of vitamin food additives. The above-mentioned trace element compound food additives may be compound food additives composed of a variety of trace element food additives.

[0035] In some optional implementations of some embodiments, the execution subject may mix the mineral salts and maltodextrin in the above-mentioned materials to obtain a mixed material and a mixed material by performing the following steps: the mineral salts, maltodextrin and compound food additives in the above-mentioned materials are mixed by a mixer to obtain a mixed material. In practice, the execution subject may mix the mineral salts, maltodextrin and compound food additives in the above-mentioned materials by an IBC (Intermediate Bulk Container) lifting mixer to obtain a mixed material. The mixing time may be 10 min. The mixing speed may be 10 rpm / min.

[0036] Step 103, preparing the mixed material and the stirred oil to obtain a prepared nutrient solution.

[0037] In some embodiments, the execution entity may prepare the mixed material and the stirred oil to obtain a prepared nutrient solution.

[0038] Optionally, the above materials may also include white sugar and egg white powder.

[0039] In some optional implementations of some embodiments, the execution subject may prepare the mixed material and the stirred oil to obtain a prepared nutrient solution by performing the following steps:

[0040] In the first step, add reverse osmosis water to the mixing tank.

[0041] The second step is to start the online mixer and the stirring paddle included in the mixing tank. In practice, after adding the reverse osmosis water, the execution body can start the mixing tank for stirring.

[0042] The third step is to add stabilizers, white sugar, maltodextrin and protein powder, stirred oil, mixed materials and flavors into the mixing tank in sequence during the stirring process. Among them, the above-mentioned stabilizer can be a chemical that increases the stability of solutions, colloids, solids, mixtures, etc. The above-mentioned stabilizer can include microcrystalline cellulose and sodium carboxymethyl cellulose. The above-mentioned stabilizer can slow down the stratification of the nutrient solution. Specifically, during the stirring process, first, the above-mentioned execution body can add stabilizers and stir them in a cycle for a first preset stirring time. Then, the above-mentioned execution body can add white sugar, and then add maltodextrin and protein powder alternately, and stir them in a cycle for a second preset stirring time. After that, the above-mentioned execution body can add stirred oil circulation and mixed materials in sequence, and stir them in a cycle for a third preset stirring time. Finally, the above-mentioned execution body can add edible flavors. Among them, the above-mentioned first preset stirring time, the above-mentioned second preset stirring time and the above-mentioned third preset stirring time can all be greater than 5 minutes.

[0043] The fourth step is to cool the material after stirring in the mixing tank to obtain the prepared nutrient solution. In practice, the execution entity can cool the material after stirring in the mixing tank by an indirect heat exchange process to obtain the prepared nutrient solution. The temperature of the prepared nutrient solution can be less than 25°C. The pH range of the prepared nutrient solution can be 7.7 to 8.2. The density range of the prepared nutrient solution can be 1.065g / ml to 1.075g / ml. The dry matter content range of the prepared nutrient solution can be 20% to 23%. The vitamin C content of the prepared nutrient solution is greater than or equal to 30mg / 100ml.

[0044] Furthermore, the execution entity may also perform density and dry matter tests on the prepared nutrient solution to determine whether additional reverse osmosis water is needed.

[0045] Step 104, homogenizing and sterilizing the prepared nutrient solution to obtain the nutrient solution.

[0046] In some embodiments, the execution entity may perform homogenization and sterilization treatment on the prepared nutrient solution to obtain the nutrient solution.

[0047] In some optional implementations of some embodiments, the execution subject may perform homogenization and sterilization treatment on the prepared nutrient solution to obtain the nutrient solution by performing the following steps:

[0048] The first step is to perform pre-homogenization on the prepared nutrient solution by a preset pre-homogenization pressure and a preset pre-homogenization temperature to obtain a pre-homogenized nutrient solution. The preset pre-homogenization pressure may range from 450 bar to 550 bar. The preset pre-homogenization temperature may range from 60°C to 70°C. Before pre-homogenization, the executive body may filter the prepared nutrient solution to obtain a filtered nutrient solution. In practice, the executive body may filter the prepared nutrient solution through a duplex filter. The duplex filter may be made of 316L stainless steel. The pore size of the duplex filter may be 1 mm.

[0049] The second step is to sterilize the pre-homogenized nutrient solution to obtain the sterilized nutrient solution. In practice, the execution entity can perform ultra-high temperature sterilization on the pre-homogenized nutrient solution to obtain the sterilized nutrient solution. The sterilization temperature can range from 135°C to 145°C. The flow rate of the liquid during the sterilization process can range from 9500L / h to 10500L / h. The ultra-high temperature sterilization time can be controlled by controlling the flow rate.

[0050] The third step is to perform post-homogenization treatment on the sterilized nutrient solution by a preset post-homogenization pressure and a preset post-homogenization temperature to obtain a nutrient solution. The preset post-homogenization pressure may range from 180 bar to 220 bar. The preset post-homogenization temperature may range from 60°C to 70°C.

[0051] Optionally, the above execution entity may further perform the following steps:

[0052] The first step is to perform aseptic filling treatment on the above nutrient solution to obtain the filled nutrient solution. Before filling, the above execution entity can sterilize the product pipeline system of the filling machine online with steam and sterilize the filling aseptic warehouse with high-temperature hydrogen peroxide gas. In practice, the above execution entity can perform aseptic filling treatment on the above nutrient solution through the filling machine to obtain the filled nutrient solution.

[0053] The second step is to perform nitrogen filling and film sealing on the nutrient solution after filling to obtain the film-sealed nutrient solution. In practice, the execution body can fill the nutrient solution after filling with nitrogen for nitrogen protection. Then, the execution body can pass the aluminum film sterilized by hydrogen peroxide gas through the high temperature bottle mouth to form a seal to obtain the film-sealed nutrient solution.

[0054] The third step is to perform a leak detection process on the nutrient solution after film sealing to obtain a leak detection result. The leak detection result can indicate that there is no leakage or there is a leak. In practice, the execution subject can perform a leak detection process on the nutrient solution after film sealing by a leak detector to obtain a leak detection result.

[0055] The fourth step is to cap the sealed nutrient solution according to the leak detection result to obtain the capped nutrient solution. In practice, in response to the leak detection result indicating no leakage, the execution subject caps the sealed nutrient solution to obtain the capped nutrient solution.

[0056] The fifth step is to perform a foreign matter detection process on the nutrient solution after the cap is added to obtain a foreign matter detection result. The foreign matter detection result can indicate the presence or absence of foreign matter. In practice, the execution subject can perform a foreign matter detection process on the nutrient solution after the cap is added by an X-ray machine to obtain a foreign matter detection result.

[0057] Step 6: According to the foreign matter detection result, the capped nutrient solution is packaged to obtain packaged nutrient solution. In practice, in response to the foreign matter detection result indicating that no foreign matter exists, the execution subject performs a packaging process on the capped nutrient solution to obtain packaged nutrient solution.

[0058] Therefore, the nutrient solution can be packaged through filling, nitrogen filling, film sealing, leak detection, foreign matter detection and packaging, so as to facilitate subsequent storage and transfer.

[0059] Continuing, when preparing complete nutrient solution for special medical purposes, there is further the following technical problem 2: when errors occur in the preparation process (for example, insufficient stirring or incorrect placement of materials), stratification of the nutrient solution may occur, further affecting the absorption and utilization of the nutrients in the nutrient solution. In response to the above technical problem 2, the conventional solution is generally: the staff checks whether stratification of the nutrient solution occurs. However, the above conventional solution still has the following problem: when the color difference of the several parts of the nutrient solution is small, the staff cannot accurately identify whether stratification occurs.

[0060] Optionally, the above execution entity may further perform the following steps:

[0061] The first step is to collect and process the nutrient solution through a camera to obtain a nutrient solution image, wherein the camera can be arranged on any side of the nutrient solution, and the camera direction of the camera is parallel to the horizontal direction of the nutrient solution.

[0062] The second step is to preprocess the nutrient solution image to obtain a preprocessed nutrient solution image. In practice, the execution subject may perform denoising and / or contrast enhancement on the nutrient solution image to obtain a preprocessed nutrient solution image. This can improve the image quality and facilitate subsequent image recognition and analysis.

[0063] The third step is to perform edge detection on the pre-processed nutrient solution image to obtain edge detection information of the nutrient solution image. The edge detection information of the nutrient solution image may include at least one edge region information. In practice, the execution subject may perform edge detection on the pre-processed nutrient solution image by using Canny edge detection or Sobel operator to obtain edge detection information of the nutrient solution image. Thus, the interface between different layers will appear as an obvious edge, so that it can be detected whether the nutrient solution has a layered interface.

[0064] In the fourth step, the pre-processed nutrient solution image is segmented according to the edge detection information of the nutrient solution image to obtain at least one nutrient solution segmented image. In practice, the execution subject may segment the edge region corresponding to each edge region information in the at least one edge region information to obtain at least one nutrient solution segmented image. Thus, the pre-processed nutrient solution image may be segmented based on the edge, and each interface may be divided into a separate image.

[0065] The fifth step is to perform feature extraction processing on each of the at least one nutrient solution segmentation image to obtain feature information of the nutrient solution segmentation image. In practice, the execution subject may perform feature extraction processing on each of the at least one nutrient solution segmentation image to obtain feature information of the nutrient solution segmentation image through various feature extraction algorithms. The feature extraction algorithms may include but are not limited to: color histogram, HSV (hue, saturation and brightness) or HSL (hue, saturation and brightness) color space, grayscale co-occurrence matrix, local binary pattern.

[0066] The sixth step is to determine the similarity of any two nutrient solution segmentation image feature information in the at least one nutrient solution segmentation image feature information obtained. In practice, the execution subject may determine the similarity of any two nutrient solution segmentation image feature information in the at least one nutrient solution segmentation image feature information obtained according to a similarity algorithm. The similarity algorithm may include but is not limited to cosine similarity, hash algorithm and Euclidean distance.

[0067] In step 7, in response to the similarity between any two nutrient solution segmentation image feature information being less than or equal to a preset similarity threshold, the nutrient solution is moved to a waste liquid tank by a grabbing device. The preset similarity threshold may be a pre-set similarity threshold. The preset nutrient solution stratification information may be information characterizing the existence of stratification in the nutrient solution.

[0068] The above-mentioned related contents, as an inventive point of an embodiment of the present disclosure, solve the second technical problem "When errors occur in the preparation process (for example, insufficient stirring or material placement errors), nutrient solution stratification may occur, further affecting the absorption and utilization of nutrients in the nutrient solution". The factors that further affect the absorption and utilization of nutrients in the nutrient solution are often as follows: When errors occur in the preparation process (for example, insufficient stirring or material placement errors), nutrient solution stratification may occur. If the above-mentioned factors are solved, the effect of maintaining the absorption and utilization of nutrients in the nutrient solution can be achieved. In order to achieve this effect, the present disclosure can collect images of nutrient solution and pre-process the collected nutrient solution images to improve the image quality. And edge detection is performed on the nutrient solution image, and image segmentation is performed according to the edge detection result, and the similarity of each image after segmentation is detected to determine whether the above nutrient solution is stratified according to the size of the similarity. Finally, when it is determined that there is a similarity less than or equal to the preset similarity threshold, that is, when there is a small similarity between two areas, it is determined that the nutrient solution is stratified, that is, the nutrient solution is unqualified, and the above nutrient solution is moved to the waste liquid tank. Therefore, the above stratification detection method can be used to determine whether the nutrient solution is stratified, and the nutrient solution with stratification can be removed, thereby leaving the nutrient solution without stratification, thereby maintaining the absorption and utilization of the nutrients in the nutrient solution.

[0069] According to experimental data, the nutrient solution prepared by the above nutrient solution preparation method is qualified in all indicators after being stored for 12 months in an environment of temperature 25±2°C and humidity RH60±10%. At the same time, the change trends of various nutrients in nutrient solutions of different filling specifications (200ml / 500ml) are basically the same.

[0070] In order to prove the effect of the nutrient solution prepared by the above nutrient solution preparation method, the following test methods and test results are provided.

[0071] First, two different nutrient solutions were prepared on three different dates. They were stored for 12 months at a temperature of 25±2°C and a humidity of RH60±10%. The specific experimental nutrient solution information is shown in the following table:

[0072]

[0073] The test results are as follows:

[0074] The decay rate ranges for protein, fat, linoleic acid, linolenic acid and carbohydrates are shown in the following table:

[0075]

[0076] The test results show that there is no significant change in nutritional indicators such as protein, fat, linoleic acid, α-linolenic acid and carbohydrates.

[0077] The range of mineral attenuation rates is shown in the following table:

[0078]

[0079]

[0080]

[0081] The test results show that there is no significant change in nutrient indicators such as minerals.

[0082] In addition, experiments have proved that the attenuation of vitamins in this nutrient solution is within a controllable narrow range, meeting the product quality requirements.

[0083] Finally, according to the test results, it can be concluded that the nutrient solution prepared by the above nutrient solution preparation method is stored for 12 months at a temperature of 25±2°C and a humidity of RH60±10%, and all indicators are qualified. And the energy density of the nutrient solution prepared by the above nutrient solution preparation method can reach 1kcal / ml. Therefore, the stability of the nutrient solution prepared by the above nutrient solution preparation method is good.

[0084] The above-mentioned embodiments of the present disclosure have the following beneficial effects: the nutrient solution prepared by the nutrient solution preparation method of some embodiments of the present disclosure can still maintain the physical and chemical stability of the nutrient solution on the basis of adding minerals, thereby improving the compliance, taste and appearance of the nutrient solution, and maintaining the absorption and utilization of the nutrients in the nutrient solution. Specifically, the reasons that affect the absorption and utilization of the nutrients in the nutrient solution are: the increase of minerals in the nutrients, the increase of metal ion concentration, the emulsion particles in the nutrient solution are more inclined to aggregate with each other, the thermal stability is reduced, stratification and precipitation occur, the physical stability is poor, and then the chemical stability is poor, resulting in poor compliance, taste and appearance of the nutrient solution. Based on this, the nutrient solution preparation method of some embodiments of the present disclosure, first, obtain materials and stirred oil. Among them, the above-mentioned materials include mineral salts and maltodextrin. Thus, the raw materials for preparing the nutrient solution can be obtained for subsequent preparation. Then, the mineral salts and maltodextrin in the above-mentioned materials are mixed to obtain the mixed material. Thus, after the mineral salts are mixed and diluted by maltodextrin, the subsequent local mineral concentration is avoided to be too high, causing protein denaturation. Afterwards, the mixed material and the stirred oil are prepared to obtain a prepared nutrient solution. Thus, the material and the oil can be prepared to obtain a prepared nutrient solution. Finally, the prepared nutrient solution is homogenized and sterilized to obtain a nutrient solution. Thus, the prepared nutrient solution can be homogenized and sterilized, and the bacteria in the nutrient solution can be reduced by the sterilization treatment, and the fluidity of the nutrient solution can be improved by the homogenization treatment, and the stability of the nutrient solution can be increased, so that the nutrients in the nutrient solution are more evenly distributed. Therefore, the nutrient solution prepared by the nutrient solution preparation method of some embodiments of the present disclosure can still maintain the stability of the nutrient solution on the basis of adding minerals, thereby improving the compliance, taste and appearance of the nutrient solution, and maintaining the absorption and utilization of the nutrients in the nutrient solution.

[0085] Reference below Figure 2 , which shows a schematic structural diagram of various electronic components included in a nutrient solution preparation device 200 suitable for implementing some embodiments of the present disclosure. Figure 2 The nutrient solution preparation device shown is merely an example and should not bring any limitation to the functions and scope of use of the embodiments of the present disclosure.

[0086] like Figure 2As shown, the nutrient solution preparation device 200 may include a processing device (e.g., a central processing unit, a graphics processing unit, etc.) 201, which can perform various appropriate actions and processes according to a program stored in a read-only memory (ROM) 202 or a program loaded from a storage device 208 to a random access memory (RAM) 203. In the RAM 203, various programs and data required for the operation of the nutrient solution preparation device 200 are also stored. The processing device 201, the ROM 202, and the RAM 203 are connected to each other via a bus 204. An input / output (I / O) interface 205 is also connected to the bus 204.

[0087] Typically, the following devices can be connected to the I / O interface 205: an input device 206 including, for example, a touch screen, a touchpad, a keyboard, a mouse, a camera, a microphone, an accelerometer, a gyroscope, etc.; an output device 207 including, for example, a liquid crystal display (LCD), a speaker, a vibrator, etc.; a storage device 208 including, for example, a magnetic tape, a hard disk, etc.; and a communication device 209. The communication device 209 can allow the nutrient solution preparation device 200 to communicate wirelessly or wired with other devices to exchange data. And a mixing device for performing a mixing operation. Among them, the above-mentioned mixing device can be a mixer. A preparation device for performing a preparation operation. Among them, the above-mentioned preparation device can be a mixing tank. A homogenization and sterilization device for performing a homogenization and sterilization operation. Among them, the above-mentioned homogenization and sterilization device can include a homogenizer and a sterilizer. Although Figure 2 The nutrient solution preparation apparatus 200 having various devices is shown, but it should be understood that it is not required to implement or have all the devices shown. More or fewer devices may be implemented or have alternatively. Figure 2 Each block shown in the figure may represent one device, or may represent multiple devices as required.

[0088] In particular, according to some embodiments of the present disclosure, the process described above with reference to the flowchart can be implemented as a computer software program. For example, some embodiments of the present disclosure include a computer program product, which includes a computer program carried on a computer-readable medium, and the computer program contains program code for executing the method shown in the flowchart. In some such embodiments, the computer program can be downloaded and installed from the network through the communication device 209, or installed from the storage device 208, or installed from the ROM 202. When the computer program is executed by the processing device 201, the above-mentioned functions defined in the method of some embodiments of the present disclosure are executed.

[0089] It should be noted that the computer-readable medium recorded in some embodiments of the present disclosure may be a computer-readable signal medium or a computer-readable storage medium or any combination of the above two. The computer-readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of computer-readable storage media may include, but are not limited to: an electrical connection with one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above. In some embodiments of the present disclosure, a computer-readable storage medium may be any tangible medium containing or storing a program that can be used by or in combination with an instruction execution system, device or device. In some embodiments of the present disclosure, a computer-readable signal medium may include a data signal propagated in a baseband or as part of a carrier wave, which carries a computer-readable program code. This propagated data signal may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The computer readable signal medium may also be any computer readable medium other than a computer readable storage medium, which may send, propagate or transmit a program for use by or in conjunction with an instruction execution system, apparatus or device. The program code contained on the computer readable medium may be transmitted using any suitable medium, including but not limited to: wires, optical cables, RF (radio frequency), etc., or any suitable combination of the above.

[0090] In some embodiments, the client and the server may communicate using any currently known or future developed network protocol such as HTTP (HyperText Transfer Protocol), and may be interconnected with any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include a local area network ("LAN"), a wide area network ("WAN"), an internet (e.g., the Internet), and a peer-to-peer network (e.g., an ad hoc peer-to-peer network), as well as any currently known or future developed network.

[0091] The computer-readable medium may be included in the nutrient solution preparation device; or it may exist independently without being assembled into the nutrient solution preparation device. The computer-readable medium carries one or more programs. When the one or more programs are executed by the nutrient solution preparation device, the nutrient solution preparation device: obtains materials and stirred oil, wherein the materials include mineral salts and maltodextrin; mixes the mineral salts and maltodextrin in the materials to obtain a mixed material; prepares the mixed material and the stirred oil to obtain a prepared nutrient solution; and homogenizes and sterilizes the prepared nutrient solution to obtain a nutrient solution.

[0092] Computer program code for performing the operations of some embodiments of the present disclosure may be written in one or more programming languages ​​or a combination thereof, including object-oriented programming languages ​​such as Java, Smalltalk, C++, and conventional procedural programming languages ​​such as "C" or similar programming languages. The program code may be executed entirely on the user's computer, partially on the user's computer, as a separate software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In cases involving a remote computer, the remote computer may be connected to the user's computer via any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computer (e.g., via the Internet using an Internet service provider).

[0093] The flow chart and block diagram in the accompanying drawings illustrate the possible architecture, function and operation of the system, method and computer program product according to various embodiments of the present disclosure. In this regard, each square box in the flow chart or block diagram can represent a module, a program segment or a part of a code, and the module, the program segment or a part of the code contains one or more executable instructions for realizing the specified logical function. It should also be noted that in some implementations as replacements, the functions marked in the square box can also occur in a sequence different from that marked in the accompanying drawings. For example, two square boxes represented in succession can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each square box in the block diagram and / or flow chart, and the combination of the square boxes in the block diagram and / or flow chart can be implemented with a dedicated hardware-based system that performs a specified function or operation, or can be implemented with a combination of dedicated hardware and computer instructions.

[0094] The units described in some embodiments of the present disclosure may be implemented by software or hardware. The units described may also be set in a processor, for example, it may be described as: a processor includes an acquisition unit, a mixing unit, a preparation unit, and a homogenization and sterilization unit. The names of these units do not constitute a limitation on the units themselves in some cases, for example, the acquisition unit may also be described as a "unit for acquiring materials and stirred oil".

[0095] The functions described above herein may be performed at least in part by one or more hardware logic components. For example, without limitation, exemplary types of hardware logic components that may be used include: field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), application specific standard products (ASSPs), systems on chips (SOCs), complex programmable logic devices (CPLDs), and the like.

[0096] The embodiment of the present disclosure also provides a nutrient solution, which may include the following raw materials in parts by weight: 20% to 90% water, 10% to 20% maltodextrin, 5% to 6% hydrolyzed whey protein powder, 3% to 4% white sugar, 1% to 2% medium-chain triglycerides, 1% to 2% vegetable oil, 0.1% to 1% dipotassium hydrogen phosphate, 0.1% to 1% calcium citrate, 0.1% to 1% sodium chloride, 0.1% to 1% vitamin compound food additives, and 0.01% to 0.01% stabilizer. .11%, choline chloride 0.01% to 0.1%, edible flavor 0.1% to 1%, magnesium oxide 0.01% to 0.1%, emulsifier 0.01% to 0.1%, trace element compound food additives 0.1% to 1%, calcium chloride 0.01% to 0.1%, compound food additives including chromium chloride, maltodextrin and nicotinamide 0.001% to 0.01% and compound food additives including sodium molybdate, maltodextrin and nicotinamide 0.0002% to 0.01%. Among them, the above-mentioned protein powder can be hydrolyzed whey protein powder. The above-mentioned vitamin compound food additive can be a compound food additive composed of multiple vitamin food additives. The above-mentioned trace element compound food additive can be a compound food additive composed of multiple trace element food additives. The above-mentioned stabilizer can be a chemical that increases the stability of solutions, colloids, solids, mixtures, etc. The above-mentioned stabilizer can include microcrystalline cellulose and sodium carboxymethyl cellulose. The stabilizer can slow down the stratification of the nutrient solution. The emulsifier can be a substance that can form a stable emulsion from a mixed liquid of two or more immiscible components. For example, the emulsifier can be citric acid fatty acid glyceride. By adding the emulsifier, an oil-in-water emulsion can be formed, so that protein and fat are better combined to form a homogeneous emulsion, and fat and protein are prevented from separating to form a fat layer. Each raw material in the nutrient solution refers to the corresponding implementation standards. The nutrient solution is mainly suitable for people over 10 years old who have limited food intake, digestion and absorption disorders, metabolic disorders and need to supplement nutrition, especially those who are intolerant to whole protein in clinical practice, and those with digestion and absorption dysfunction caused by various clinical conditions. It is suitable for people including but not limited to those with nutritional risks, malnutrition, swallowing disorders, low body weight, weight loss, muscle loss, etc., and those with gastrointestinal function. People with insufficient intake and increased demand can also choose the nutrient solution. The energy density is 1.0kcal / mL. The protein source is 100% hydrolyzed whey protein, and the hydrolyzed peptides are absorbed and digested quickly, which can reduce abdominal distension in the patient population. About 50% of the fat source is medium chain triglycerides. The above nutrient solution does not contain dietary fiber. The above nutrient solution can be used for oral administration and tube feeding, can be used as a single nutrient source to meet the nutritional needs of the target population, and can also be used as a nutritional supplement for daily diet.

[0097] Continuous nutritional supplementation is an important prerequisite to ensure that patients can effectively improve or enhance their nutritional status, and compliance with nutrient solution is particularly important for continuous nutritional supplementation. The way the nutrient solution is used, energy density, nutrient content, taste and flavor will affect the compliance with the nutrient solution.

[0098] For ease of use, the above-mentioned nutrient solution is designed to be a liquid that is easy to drink; in order to improve the patient's tolerance, the energy density of the above-mentioned nutrient solution is designed to be 1.0kcal / mL; in order to meet the nutritional needs of the applicable population, especially various populations with digestive and absorption disorders, the above-mentioned nutrient solution selects easily digestible and absorbable hydrolyzed whey protein as the source of protein, and selects easily digestible and absorbable medium-chain triglycerides as the source of fat, and does not add dietary fiber. In terms of vitamins and minerals, considering that patients who usually need nutritional support may already be in a state of trace element and vitamin depletion, and the requirement for nutrients may increase due to disease factors. And the lack of trace elements can cause a variety of clinical and subclinical symptoms. Therefore, the above-mentioned nutrient solution increases the vitamin and mineral content, and adds chromium, molybdenum and choline. In addition, the above-mentioned nutrient solution not only covers the bitterness of hydrolyzed whey protein, but also makes the product reach a suitable flavor; the use compliance of the above-mentioned nutrient solution is improved from the above aspects.

[0099] The above descriptions are only some preferred embodiments of the present disclosure and an explanation of the technical principles used. Those skilled in the art should understand that the scope of the invention involved in the embodiments of the present disclosure is not limited to the technical solutions formed by a specific combination of the above-mentioned technical features, but should also cover other technical solutions formed by any combination of the above-mentioned technical features or their equivalent features without departing from the above-mentioned inventive concept. For example, the above-mentioned features are replaced with the technical features with similar functions disclosed in the embodiments of the present disclosure (but not limited to) and the technical solutions formed.

Claims

1. A method for preparing a nutrient solution, comprising: Obtaining materials and stirred oil, including: quantitatively injecting at least one oil and an emulsifier into a hot oil tank through a pipeline; heating and stirring the injected at least one oil and emulsifier through the hot oil tank to obtain stirred oil, wherein the heating temperature is greater than 80° C., the emulsifier is citric acid fatty acid glyceride, and the materials include mineral salts and maltodextrin; Mixing the mineral salt and maltodextrin in the material to obtain a mixed material; The mixed material and the stirred oil are compounded to obtain a compounded nutrient solution; Performing homogenization and sterilization treatment on the prepared nutrient solution to obtain a nutrient solution; Performing image acquisition and processing on the nutrient solution by a camera device to obtain a nutrient solution image, wherein the camera device is arranged on any side of the nutrient solution, and the camera direction of the camera device is parallel to the horizontal direction in which the nutrient solution is placed; Preprocessing the nutrient solution image to obtain a preprocessed nutrient solution image; Performing edge detection on the preprocessed nutrient solution image to obtain edge detection information of the nutrient solution image; According to the edge detection information of the nutrient solution image, segmenting the preprocessed nutrient solution image to obtain more than one nutrient solution segmented image; performing feature extraction processing on each of the more than one nutrient solution segmentation images to obtain feature information of the nutrient solution segmentation image; Determine the similarity of any two nutrient solution segmentation image feature information among the obtained more than one nutrient solution segmentation image feature information; In response to confirming that the similarity of feature information of any two nutrient solution segmentation images is less than or equal to a preset similarity threshold, moving the nutrient solution to a waste liquid tank by a grabbing device; The materials also include white sugar and protein powder; and The mixed material and the stirred oil are prepared to obtain a prepared nutrient solution, comprising: Add reverse osmosis water to the mixing tank; Starting the online mixer and stirring paddle included in the mixing tank; During the stirring process, stabilizer, white sugar, maltodextrin and protein powder, stirred oil, mixed material and flavor are sequentially added into the mixing tank, wherein the stabilizer comprises microcrystalline cellulose and sodium carboxymethyl cellulose, wherein the stabilizer is added and stirred cyclically for a first preset stirring time, white sugar is added, and then maltodextrin and protein powder are alternately added and stirred cyclically for a second preset stirring time, the stirred oil and mixed material are sequentially added and stirred cyclically for a third preset stirring time, and finally the edible flavor is added; The material stirred in the mixing tank is cooled to obtain a prepared nutrient solution.

2. The method according to claim 1, wherein: The material also includes compound food additives; and The method of mixing the mineral salt and maltodextrin in the material to obtain a mixed material comprises: The mineral salt, maltodextrin and compound food additives in the material are mixed by a mixer to obtain a mixed material.

3. The method according to claim 1, wherein: The step of subjecting the prepared nutrient solution to homogenization and sterilization to obtain the nutrient solution comprises: Performing a pre-homogenization treatment on the prepared nutrient solution by using a preset pre-homogenization pressure and a preset pre-homogenization temperature to obtain a pre-homogenized nutrient solution; sterilizing the pre-homogenized nutrient solution to obtain a sterilized nutrient solution; The sterilized nutrient solution is subjected to post-homogenization treatment at a preset post-homogenization pressure and a preset post-homogenization temperature to obtain the nutrient solution.

4. The method according to claim 1, wherein: The method further comprises: Performing aseptic filling treatment on the nutrient solution to obtain filled nutrient solution; Performing nitrogen filling and film sealing treatment on the filled nutrient solution to obtain a film-sealed nutrient solution; Performing a leak detection process on the sealed nutrient solution to obtain a leak detection result; According to the leak detection result, the sealed nutrient solution is capped to obtain the capped nutrient solution; Performing foreign matter detection processing on the capped nutrient solution to obtain a foreign matter detection result; According to the foreign matter detection result, the capped nutrient solution is packaged to obtain packaged nutrient solution.

5. A nutrient solution preparation device, comprising: one or more processors; a storage device having one or more programs stored thereon; A mixing device for performing a mixing operation; A preparation device, used to perform a preparation operation; A homogenizing and sterilizing device, used for performing a homogenizing and sterilizing operation; When the one or more programs are executed by the one or more processors, the one or more processors implement the method according to any one of claims 1 to 4.

6. A computer readable medium having a computer program stored thereon, wherein: When the program is executed by a processor, the method according to any one of claims 1 to 4 is implemented.

Citation Information

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