Constant temperature box for preparing hydrogel by freeze-thaw method and preparation method of constant temperature box

Abstract

The present invention relates to the technical field of hydrogel preparation, and in particular to a thermostat for preparing hydrogel by freeze-thaw method and a method for preparing the thermostat, comprising a box body, an upper cover plate on the top of the box body, a front cover plate on the front side of the box body, a plurality of evenly distributed air outlets on the upper cover plate, a storage cavity and a drainage cavity inside the box body, the storage cavity is located on the upper side of the drainage cavity, a plurality of parallel porous storage tables are provided in the storage cavity, a blower mechanism 1 is provided on one side of the storage table, a blower mechanism 2 is provided on the right side of the drainage cavity and on the lower side of the storage table, and a drainage hole is provided on one side of the drainage cavity. The present invention adopts the above technical scheme, the thermostat is small in size and can be placed inside a refrigerator, and a blower mechanism is installed inside to facilitate the air flow inside the thermostat, which solves the problem of different mechanical properties of the same batch of hydrogels caused by uneven temperature distribution inside the equipment refrigerated by a compressor in the prior art.

Description

Technical Field

[0001] The invention relates to the technical field of hydrogel preparation, in particular to a thermostat for preparing hydrogel by freeze-thaw method and a preparation method of the thermostat. Background Art

[0002] Gel refers to a dispersed system in which swollen high molecular polymers are interconnected to form a three-dimensional spatial network structure, and the gaps in the network structure are filled with liquid media. High molecular water gel (also known as hydrogel) is an important material in the field of basic research technology. Hydrogel is a high molecular polymer that contains a large amount of water in its network structure and is insoluble in water. It has good softness, elasticity, liquid storage capacity and biocompatibility, and has a wide range of uses in biomedicine and bioengineering. PVA (polyvinyl alcohol) hydrogel prepared by the repeated freeze-thaw method in the physical cross-linking method is one of the typical hydrogels. The preparation of PVA hydrogel using the repeated freeze-thaw method means storing the PVA solution at a certain low temperature for a period of time, and then placing it at room temperature for a period of time, so as to obtain a hydrogel with certain mechanical properties.

[0003] The low-temperature equipment used in the prior art is generally a refrigerator or a freezer, but this type of equipment is usually cooled by a compressor. At the same time, due to its large internal cavity, the internal temperature distribution is not very uniform, which can easily cause large differences in the mechanical properties of the same batch of hydrogels prepared by the freeze-thaw method. Summary of the invention

[0004] The purpose of the present invention is to provide a thermostatic box for preparing hydrogel by freeze-thaw method and a preparation method of the thermostatic box. The thermostatic box is small in size and can be placed inside a refrigerator. A blower mechanism is installed inside to facilitate air flow inside the thermostatic box, thereby solving the problem of different mechanical properties of the same batch of hydrogels caused by uneven temperature distribution inside equipment refrigerated by a compressor in the prior art.

[0005] To achieve the above-mentioned purpose, the present invention provides a constant temperature box for preparing hydrogel by freeze-thaw method, including a box body, an upper cover plate is provided on the top of the box body, a front cover plate is provided on the front side of the box body, a plurality of evenly distributed air outlet holes are provided on the upper cover plate, a storage cavity and a drainage cavity are provided inside the box body, the storage cavity is located on the upper side of the drainage cavity, a plurality of parallel porous storage tables are provided in the storage cavity, a blower mechanism 1 is provided on one side of the storage table, a blower mechanism 2 is provided on the right side of the drainage cavity and on the lower side of the storage table, and a drainage hole is provided on one side of the drainage cavity.

[0006] Preferably, the main body of the box is formed by splicing acrylic plates, and adjacent acrylic plates are connected by an adhesive.

[0007] Preferably, one side between two adjacent storage tables is connected via a support block, and the other side between two adjacent storage tables is connected via a fan support frame, and a hair dryer structure is installed in the fan support frame.

[0008] Preferably, a plurality of support rods 1 for supporting the storage table are provided on the top of the drainage cavity, and one end of the support rod 1 is respectively connected to the front and rear side walls of the box body through fixing pins.

[0009] Preferably, an inclined drainage board is provided in the drainage cavity at the lower side of the storage cavity, the bottom end of the drainage board is connected to the bottom plate of the box through a support plate, the top end of the drainage board is connected to the bottom of the box through a support block 2, and a blower structure 2 is provided on the lower side of the drainage board.

[0010] Preferably, the inclination angle of the drain board is 5°.

[0011] Preferably, a ventilation cavity 1 is formed between the fan support frame and the side wall of the box body, a ventilation cavity 2 is formed between the drain plate and the bottom plate of the box body, and the ventilation cavity 1 is communicated with the ventilation cavity 2.

[0012] A method for preparing a thermostat for preparing hydrogel by freeze-thaw method, the method is used to prepare the above-mentioned thermostat for preparing hydrogel by freeze-thaw method, specifically as follows:

[0013] S1. Use SOLIDWORKS to build a box model, adjust the size of each component and the size and position of the opening, and assemble the components into a box model;

[0014] S2, cutting the acrylic sheet according to the size designed in S1;

[0015] S3, fixing the hair dryer structure 1 and the hair dryer structure 2 to the corresponding acrylic plate using bolts;

[0016] S4. According to the box model structure of S1, all parts are bonded together using adhesive.

[0017] Beneficial effects of the present invention:

[0018] The present invention provides a thermostat for preparing hydrogel by freeze-thaw method. The thermostat is small in size and can be placed inside a refrigerator. A blower mechanism is installed inside the thermostat to facilitate air flow inside the thermostat, so that the temperature inside the thermostat is evenly distributed. There is no obvious temperature difference in the thermostat. A drainage cavity is also provided at the bottom of the thermostat to collect water vapor entering the thermostat from the refrigerator, so that the water vapor can be collected and then processed centrally. The mechanical properties of the hydrogel prepared by the thermostat provided by the present invention are basically the same, which is conducive to improving the stability of the hydrogel and facilitating the use of the prepared hydrogel for experiments.

[0019] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 Schematic diagram of a thermostat used for preparing hydrogel by freeze-thaw method of the present invention;

[0021] Figure 2 It is a schematic diagram of the internal structure of a thermostat used for preparing hydrogel by freeze-thaw method of the present invention;

[0022] Figure 3 is a cross-sectional view of a thermostat used for preparing hydrogel by freeze-thaw method of the present invention;

[0023] Figure 4 It is a schematic diagram of the drainage hole of the thermostat used for preparing hydrogel by freeze-thaw method of the present invention.

[0024] Reference numerals:

[0025] 1. Box body; 2. Upper cover; 3. Front cover; 4. Air outlet; 5. Storage cavity; 6. Drainage cavity; 7. Storage table; 8. Drainage hole; 9. Support block 1; 10. Fan support frame; 11. Hair dryer structure 1; 12. Ventilation cavity 1; 13. Support rod 1; 14. Drainage board; 15. Support plate; 16. Support block 2; 17. Hair dryer structure 2; 18. Fixing pin; 19. Ventilation cavity 2. DETAILED DESCRIPTION

[0026] The present invention is further described below in conjunction with the accompanying drawings and embodiments. Unless otherwise defined, the technical terms or scientific terms used in the present invention should be the common meanings understood by people with ordinary skills in the field to which the present invention belongs. The above-mentioned features or features mentioned in the specific examples mentioned in the present invention can be combined arbitrarily, and these specific embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0027] Example 1

[0028] See also Figures 1 to 4 As shown in the figure, the present invention provides a constant temperature box for preparing hydrogel by freeze-thaw method, including a box body 1. The main body of the box body 1 is made of acrylic plates, which is easy to install and has a light overall structure, which is convenient to move or carry. Adjacent acrylic plates are connected by adhesives, and the adhesive used is a special acrylic adhesive in the prior art. An upper cover plate 2 is provided on the top of the box body 1, and a front cover plate 3 is provided on the front side of the box body 1. The front cover plate 3 is detachably connected to the box body 1 through the prior art, so that the sample can be placed in the box body 1 after the front cover plate 3 is opened. A plurality of evenly distributed air outlet holes 4 are provided on the upper cover plate 2 to facilitate air circulation inside the box body 1.

[0029] The box body 1 is provided with a storage chamber 5 and a drainage chamber 6. The storage chamber 5 is located on the upper side of the drainage chamber 6. A plurality of parallel porous storage tables 7 are provided in the storage chamber 5. A drainage hole 8 is provided on one side of the drainage chamber 6. A piston is detachably connected to the drainage hole 8. The storage table 7 is used to place samples. The porous setting of the storage table 7 is convenient for improving the air circulation in the storage chamber 5. The setting of the drainage chamber 6 is convenient for collecting the condensed water in the constant temperature box and discharging it to the outside in a unified manner.

[0030] One side between two adjacent storage tables 7 is connected by a support block 9, and the other side between two adjacent storage tables 7 is connected by a fan support frame 10. A hair dryer structure 11 is installed in the fan support frame 10. A ventilation cavity 12 is formed between the fan support frame 10 and the side wall of the box body 1. The hair dryer structure 11 blows the air in the ventilation cavity 12 to the space above the storage table 7. While ensuring the stability of the storage table 7, it promotes the air circulation in the storage cavity 5 and ensures the temperature balance in the area of ​​the storage table 7.

[0031] The top of the drainage cavity 6 is provided with a plurality of support rods 13 for supporting the storage table 7. One end of the support rod 13 is connected to the front and rear side walls of the box body 1 through a fixing pin 18. The support rod 13 is arranged at the lower side of the storage table 7 at the bottom layer to provide support for the storage table 7 and further improve the stability of the storage table 7. An inclined drainage board 14 is arranged at the lower side of the storage cavity 5 in the drainage cavity 6. The inclination angle of the drainage board 14 is 5°, which is convenient for water vapor to condense at the drainage board 14 and flow to the lower end and be collected in the drainage cavity 6.

[0032] The lower end of the drain plate 14 is connected to the bottom plate of the box body 1 through the support plate 15, and the upper end of the drain plate 14 is connected to the bottom of the box body 1 through the support block 16. The lower side of the drain plate 14 is provided with a blower structure 17. The bottom plate of the box body 1 is provided with a through hole for installing the blower structure 17. The blower structure 11 and the blower structure 17 are fans with a power supply control device system in the prior art. A ventilation cavity 19 is formed between the drain plate 14 and the bottom plate of the box body 1. The ventilation cavity 12 is connected to the ventilation cavity 19. The cold air in the refrigerator is blown into the ventilation cavity 19 through the blower structure 17, and then the cold air enters the ventilation cavity 12 through the ventilation cavity 19. The blower structure 11, the blower structure 17 and the air outlet 4 cooperate to facilitate the cold air in the refrigerator to enter the thermostat, and promote the circulation of the air inside the thermostat, so that the temperature inside the thermostat is uniform.

[0033] Specific use process:

[0034] When using the thermostat for preparing hydrogel by freeze-thaw method provided by the present invention, the front cover 3 is first opened, the mold containing the sample is placed on the storage table 7, and then the front cover 3 is installed, the thermostat is placed in the refrigerator, and the blower structure 11 and the blower structure 2 17 are turned on to circulate the air in the thermostat to cool the sample. After the cooling is completed according to the set time, the front cover 3 is opened to take out the mold.

[0035] Example 2

[0036] A method for preparing a thermostat for preparing hydrogels by freeze-thaw method, the method for preparing the above-mentioned thermostat for preparing hydrogels by freeze-thaw method is as follows:

[0037] S1. Use SOLIDWORKS to build a box model, adjust the size of each component and the size and position of the opening, and assemble the components into a box model;

[0038] S2, cutting the acrylic sheet according to the size designed in S1, the thickness of the acrylic sheet is 5mm;

[0039] S3, fixing the hair dryer structure 1 and the hair dryer structure 2 to the corresponding acrylic plate using bolts;

[0040] S4. According to the box model structure of S1, all parts are bonded together using adhesive.

[0041] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solution of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solution to deviate from the spirit and scope of the technical solution of the present invention.

Claims

1. A constant temperature box for preparing hydrogel by freeze-thaw method, comprising a box body, an upper cover plate is provided on the top of the box body, and a front cover plate is provided on the front side of the box body, characterized in that: The upper cover plate is provided with a plurality of evenly distributed air outlet holes, the interior of the box body is provided with a storage cavity and a drainage cavity, the storage cavity is located on the upper side of the drainage cavity, a plurality of parallel porous storage tables are provided in the storage cavity, a hair dryer structure 1 is provided on one side of the storage table, a hair dryer structure 2 is provided on the right side of the drainage cavity and on the lower side of the storage table, and a drainage hole is provided on one side of the drainage cavity.

2. A constant temperature box for preparing hydrogel by freeze-thaw method according to claim 1, characterized in that: The main body of the box is made of acrylic panels, and adjacent acrylic panels are connected by adhesives.

3. The thermostat for preparing hydrogel by freeze-thaw method according to claim 1, characterized in that: One side between two adjacent storage tables is connected through a support block 1, and the other side between the two adjacent storage tables is connected through a fan support frame, and a hair dryer structure 1 is installed in the fan support frame.

4. The incubator for preparing hydrogel by freeze-thaw method according to claim 1, characterized in that: A plurality of support rods 1 for supporting the storage platform are arranged on the top of the drainage cavity, and two ends of the support rods 1 are respectively connected to the front and rear side walls of the box body through fixing pins.

5. The thermostat for preparing hydrogel by freeze-thaw method according to claim 3, characterized in that: An inclined drainage board is provided in the drainage cavity at the lower side of the storage cavity. The lower end of the drainage board is connected to the bottom plate of the box through a support plate, and the high end of the drainage board is connected to the bottom of the box through a second support block. A blower structure 2 is provided on the lower side of the drainage board.

6. A constant temperature box for preparing hydrogel by freeze-thaw method according to claim 5, characterized in that: The inclination angle of the drain board is 5°.

7. The incubator for preparing hydrogel by freeze-thaw method according to claim 5, characterized in that: A ventilation cavity 1 is formed between the fan support frame and the side wall of the box body, a ventilation cavity 2 is formed between the drain plate and the bottom plate of the box body, and the ventilation cavity 1 is communicated with the ventilation cavity 2.

8. A method for preparing a thermostat for preparing hydrogel by freeze-thaw method, characterized in that: The preparation method is used to prepare a thermostat for preparing a hydrogel by freeze-thaw method as described in any one of claims 1 to 7, and is specifically as follows: S1. Use SOLIDWORKS to build a box model, adjust the size of each component and the size and position of the opening, and assemble the components into a box model; S2, cutting the acrylic sheet according to the size designed in S1; S3, fixing the hair dryer structure 1 and the hair dryer structure 2 to the corresponding acrylic plate using bolts; S4. According to the box model structure of S1, all parts are bonded together using adhesive.

Images