A stable composition containing polydatin and preparation method thereof

Abstract

The present invention discloses a stable composition comprising polydatin, which comprises the following raw materials in parts by weight: 8-30 parts of polydatin, 30-60 parts of tea polyphenols, 7-20 parts of urea, and 20-50 parts of modified dextrin. The stable composition comprising polydatin provided by the present invention comprises polydatin by inclusion of modified dextrin, thereby improving the water solubility of polydatin and expanding the application of polydatin in cosmetics. Meanwhile, the moisture retention and light stability of modified dextrin can also improve the light stability of polydatin. Meanwhile, tea polyphenols and urea are added, and the raw materials act synergistically to further improve the antioxidant property and moisture retention of the composition, so that the prepared stable composition can be better applied to cosmetics.

Description

Technical Field

[0001] The present invention belongs to the technical field of compositions, and particularly relates to a stable composition comprising polydatin and a preparation method thereof. Background Art

[0002] The skin acts as an effective barrier against harmful environmental and exogenous substances, protecting various organs in the human body. Excessive or prolonged exposure to ultraviolet rays can cause numerous skin diseases and is a key factor in the development of dry skin, flaking, wrinkling, abnormal pigmentation, and even skin cancer.

[0003] Skincare cosmetics have become a necessity in people's lives, and their effectiveness is often scientifically and objectively demonstrated through moisturizing and anti-aging claims. The free radical theory plays a crucial role in anti-aging research. Environmental factors such as ultraviolet rays, smog, radiation, smoking, and poor sleep habits increase free radical production in the body, causing cumulative damage to normal cells and tissues, leading to cross-linking and polymerization of skin elastic fibers and accelerating skin aging.

[0004] The formation of free radicals is widely believed to play an important role in the mechanism of skin aging. Free radicals are highly reactive molecular species with unpaired electrons that can directly damage various cell membranes, lipids, proteins, RNA, and DNA. The damaging effects of these free radicals, usually present in the form of reactive oxygen species, are induced internally in tissues and cells during normal metabolic processes and externally through various oxidative stresses. Ultraviolet radiation and environmental pollution can accelerate skin aging by generating free radicals in the skin. Effective free radical scavengers can remove excess free radicals and slow the aging of the skin. In addition, free radical scavenging is also one of the mechanisms of action of active substances with whitening, sun protection and other effects.

[0005] Antioxidants can protect cells from oxidative stress by scavenging free radicals and inhibiting oxidative reactions. Topical application of antioxidants is widely used in skin care products to prevent skin aging. Polydatin is a substance with antioxidant properties and the main active ingredient in Polygonum cuspidatum root extract. It is a product of resveratrol and glucose, also known as resveratrol glycosides. Polydatin and resveratrol have similar pharmacological effects and can be converted into each other in the body. Polydatin has stronger antioxidant effects and greater stability.

[0006] However, due to the fact that polydatin is poorly soluble in water, it is particularly difficult to add it to cosmetic formulas, or difficult to add it in an amount sufficient to produce an effect. In addition, polydatin is sensitive to light and becomes unstable when exposed to light, which limits the application of polydatin in cosmetics. Summary of the Invention

[0007] In view of the deficiencies of the prior art, the object of the present invention is to provide a stable composition containing polydatin and a preparation method thereof, which can improve the solubility of polydatin in pure water and increase the amount of polydatin added in cosmetics. The composition has a moisturizing effect and the stability of polydatin is also improved to a certain extent.

[0008] To achieve the above object, the present invention provides the following technical solutions:

[0009] A stable composition containing polydatin, comprising the following raw materials in parts by weight:

[0010] 8-30 parts of polydatin, 30-60 parts of tea polyphenols, 7-20 parts of urea, and 20-50 parts of modified dextrin.

[0011] Preferably, a stable composition containing polydatin comprises the following raw materials in parts by weight:

[0012] 10-25 parts of polydatin, 40-50 parts of tea polyphenols, 8-16 parts of urea, and 25-40 parts of modified dextrin.

[0013] Preferably, a stable composition containing polydatin comprises the following raw materials in parts by weight:

[0014] 15-20 parts of polydatin, 45-50 parts of tea polyphenols, 9-12 parts of urea, and 25-30 parts of modified dextrin.

[0015] In the present invention, polydatin, chemically known as 3,4',5-trihydroxystilbene-3-β-mono-D-glucoside, is a monomer extracted from the traditional Chinese medicine Polygonum cuspidatum and belongs to the stilbene family of compounds. It has the effects of scavenging free radicals, limiting strong oxidative stress, and inhibiting the production of inflammatory factors. These benefits can be used in skin care products, including the compositions according to the present invention. When the skin is inflamed or requires whitening and antioxidant treatment, polydatin scavenges free radicals and eliminates inflammatory factors, promoting skin whitening and stabilizing inflamed areas.

[0016] Tea polyphenols is a general term for the polyphenols found in tea. Its main components are six compounds: flavanones, anthocyanidins, flavonols, anthocyanidins, phenolic acids, and desquamated phenols. Tea polyphenols possess excellent antibacterial properties and can inhibit oxidases. They can prevent and treat skin diseases, allergies, reduce skin pigmentation, and prevent wrinkles. These properties have led to their use as antioxidants, preservatives, anti-wrinkle agents, skin whitening agents, radiation shields, and sunscreens in cosmetics and daily necessities. Tea polyphenols are also readily available and relatively affordable.

[0017] Urea is a commonly used moisturizing ingredient found in the skin's stratum corneum. It is a key component of the skin's natural moisturizing factor (NMF). Urea moisturizes and softens the stratum corneum. It is also non-irritating and suitable for sensitive skin. Urea is stable in both acidic and alkaline environments at room temperature and does not readily decompose.

[0018] Preferably, the preparation method of the modified dextrin comprises the following steps:

[0019] S1, adding β-cyclodextrin to deionized water, adding sodium hydroxide solution to adjust the pH to 11-12, and performing activation reaction. After the reaction is completed, adding acetone to precipitate, filtering, washing, and drying to obtain pretreated β-cyclodextrin;

[0020] S2, adding the pretreated β-cyclodextrin in step S1 to N,N-dimethylformamide, followed by adding succinic anhydride and p-toluenesulfonic acid, stirring to react, adding dichloromethane to precipitate after the reaction is completed, filtering, washing, and drying to obtain carboxylated β-cyclodextrin;

[0021] S3, adding thionyl chloride to the carboxylated β-cyclodextrin in step S2, heating the mixture to react, and removing the thionyl chloride by rotary evaporation after the reaction is completed to obtain an intermediate product;

[0022] S4. Add the intermediate product in step S3 into deionized water, then add glycerol, 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and pyridine, and react at a constant temperature under a nitrogen atmosphere. After the reaction is completed, add dichloromethane to precipitate, filter, wash, and dry to obtain the modified dextrin.

[0023] Preferably, the concentration of the sodium hydroxide solution in step S1 is 0.4-0.8 mol / L, the temperature of the activation reaction is 45-55° C., and the reaction time is 2-3 h.

[0024] Preferably, in step S2, the mass ratio of the pretreated β-cyclodextrin, succinic anhydride, and p-toluenesulfonic acid is 50:30-40:5-10; the stirring reaction temperature is 75-85° C., and the time is 3-4 hours.

[0025] Preferably, in step S3, the mass ratio of the carboxylated β-cyclodextrin to thionyl chloride is 50:600-800, the temperature of the heating reaction is 70-75° C., and the reaction time is 6-10 h.

[0026] Preferably, in step S4, the mass ratio of the intermediate product, glycerol, 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and pyridine is 50:30-40:5-9:0.5-1, and the isothermal reaction temperature is 80-90° C. and the reaction time is 5-8 h.

[0027] In the present invention, β-cyclodextrin is an ideal solubilizer and pharmaceutical excipient for injections. It can improve the water solubility of poorly soluble drugs, enhance drug stability, and improve drug bioavailability, thereby increasing the therapeutic efficacy or reducing the dosage of the drug. It can also adjust or control the drug release rate and reduce drug toxicity and side effects. Modification of β-cyclodextrin further improves its water solubility and stability. It can be used as a stabilizer, emulsifier, deodorant, etc. in cosmetic raw materials. It can reduce the irritation of organic molecules in cosmetics to skin and mucous membranes, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients.

[0028] The present invention also protects a method for preparing the stable composition containing polydatin as described above, comprising the following steps:

[0029] Polydatin is added to ethanol and stirred to dissolve to obtain a polydatin solution; modified dextrin is added to deionized water and stirred to dissolve to obtain a modified dextrin solution; the polydatin solution is then added to the modified dextrin solution and ultrasonically treated. After the treatment is completed, the mixture is stirred at 50-60°C for 3-4 hours, cooled to room temperature, urea and tea polyphenols are added, the mixture is stirred evenly, and then reduced pressure concentration and freeze-drying are performed to obtain the stable composition containing polydatin.

[0030] The present invention also protects the use of the stable composition containing polydatin as described above in cosmetics or skin care products.

[0031] Preferably, the skin care product can be lotion, cream, essence, etc.

[0032] More preferably, the composition of the present invention can be used as a cosmetic product as it is, or the composition of the present invention can be used as an element of a cosmetic product. For example, the composition of the present invention can be added to any other element or combined with any other element to form a cosmetic product.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) The stable composition containing polydatin provided by the present invention includes polydatin by inclusion in modified dextrin, thereby improving the water solubility of polydatin and expanding the application of polydatin in cosmetics. At the same time, the modified dextrin has the moisture retention and photostability, which can also improve the photostability of polydatin. At the same time, tea polyphenols and urea are added, and the synergistic effect between the raw materials further improves the antioxidant and moisture retention properties of the composition, so that the prepared stable composition can be better used in cosmetics.

[0035] (2) The present invention provides a stable composition containing polydatin, wherein the modified dextrin is added, and β-cyclodextrin is used as a raw material, which is first subjected to an alkali heat treatment to improve the activity of the alcohol hydroxyl group on the surface of the β-cyclodextrin, which is beneficial to the subsequent reaction; then the pretreated β-cyclodextrin is reacted with succinic anhydride to allow the succinic anhydride to be connected to the β-cyclodextrin, thereby introducing an active carboxyl group, thereby improving the hydrophilicity of the molecule and also being beneficial to the subsequent reaction; then the carboxylated β-cyclodextrin is added to thionyl chloride to chlorinate the carboxyl group in the β-cyclodextrin to improve its reaction activity, and finally the intermediate product is reacted with propylene glycol, 2-hydroxy-4-methoxy-5-sulfonic acid diol The benzophenone reacts with glycerol and 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone through the reaction between the acyl chloride group and the hydroxyl group, so that glycerol and 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone are connected to the β-cyclodextrin. The glycerol has good moisturizing and hydrophilic properties, and the sulfonic acid group contained in the 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone also has good hydrophilicity. At the same time, the 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, as an ultraviolet light absorber, also has good light stability. The two are introduced into the β-cyclodextrin through chemical bonds, which greatly improves the water solubility and light stability of the β-cyclodextrin, so that the prepared composition has good water solubility, moisturizing and light stability. DETAILED DESCRIPTION

[0036] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] The tea polyphenols were purchased from Shaanxi Sinot Biotechnology Co., Ltd. and were mainly flavanols (catechins), with catechins accounting for 60-80%.

[0038] Example 1

[0039] A method for preparing a stable composition containing polydatin comprises the following steps:

[0040] 15 g of polydatin was added to 80 mL of ethanol and stirred to dissolve to obtain a polydatin solution; 30 g of modified dextrin was added to 400 mL of deionized water and stirred to dissolve to obtain a modified dextrin solution; the polydatin solution was then added to the modified dextrin solution, ultrasonically treated at a power of 200 W for 20 minutes, stirred at 55° C. for 3.5 hours after the treatment, cooled to room temperature after the stirring was completed, 15 g of urea and 45 g of tea polyphenols were added, stirred evenly, concentrated under reduced pressure at 50 kPa and 80° C. to 1 / 3 of the volume, and freeze-dried to obtain the stable composition containing polydatin.

[0041] Wherein, the preparation method of the modified dextrin is as follows:.

[0042] S1. Add 10 g of β-cyclodextrin to 1 L of deionized water, add 0.6 mol / L sodium hydroxide solution to adjust the pH to 12, and react at 50°C for 2.5 hours. After the reaction is complete, add acetone to precipitate, centrifuge and filter, wash with anhydrous ethanol three times, and dry at 80°C for 5 hours to obtain pretreated β-cyclodextrin;

[0043] S2, adding 50g of pretreated β-cyclodextrin in step S1 to 1L N, N-dimethylformamide, followed by adding 35g of succinic anhydride and 8g of p-toluenesulfonic acid, stirring and reacting at 80°C for 3.5h, adding 4 times the volume of dichloromethane to precipitate after the reaction is completed, filtering, washing with anhydrous ethanol 3 times, and drying at 80°C for 4h to obtain carboxylated β-cyclodextrin;

[0044] S3, adding 50g of carboxylated β-cyclodextrin in step S2 to 700g of thionyl chloride, reacting at 75°C for 8h, and removing thionyl chloride by rotary evaporation after the reaction is completed to obtain an intermediate product;

[0045] S4, adding 50g of the intermediate product in step S3 to 900g of deionized water, followed by adding 35g of glycerol, 7g of 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and 0.8g of pyridine, and reacting at 85°C for 7h under a nitrogen atmosphere. After the reaction is completed, 4 times the volume of dichloromethane is added for precipitation, filtered, washed with anhydrous ethanol 3 times, and dried at 80°C for 4h to obtain the modified dextrin.

[0046] Example 2

[0047] A method for preparing a stable composition containing polydatin comprises the following steps:

[0048] 8 g of polydatin was added to 80 mL of ethanol, stirred and dissolved to obtain a polydatin solution; 20 g of modified dextrin was added to 400 mL of deionized water, stirred and dissolved to obtain a modified dextrin solution; the polydatin solution was then added to the modified dextrin solution, ultrasonically treated at a power of 200 W for 20 minutes, stirred at 50° C. for 4 hours after the treatment, cooled to room temperature after the stirring was completed, 20 g of urea and 52 g of tea polyphenols were added, stirred evenly, concentrated under reduced pressure at 40 kPa and 75° C. to 1 / 3 of the volume, and freeze-dried to obtain the stable composition containing polydatin.

[0049] Wherein, the preparation method of the modified dextrin is as follows:.

[0050] S1. Add 10 g of β-cyclodextrin to 1 L of deionized water, add 0.4 mol / L sodium hydroxide solution to adjust the pH to 11, and react at 45°C for 3 h. After the reaction is complete, add acetone to precipitate, centrifuge and filter, wash with anhydrous ethanol three times, and dry at 80°C for 5 h to obtain pretreated β-cyclodextrin;

[0051] S2, adding 50g of pretreated β-cyclodextrin in step S1 to 1L N, N-dimethylformamide, followed by adding 30g of succinic anhydride and 5g of p-toluenesulfonic acid, stirring and reacting at 75°C for 4h, adding 4 times the volume of dichloromethane to precipitate after the reaction is completed, filtering, washing with anhydrous ethanol 3 times, and drying at 80°C for 4h to obtain carboxylated β-cyclodextrin;

[0052] S3, adding 50g of carboxylated β-cyclodextrin in step S2 to 600g of thionyl chloride, reacting at 70°C for 10h, and removing thionyl chloride by rotary evaporation after the reaction is completed to obtain an intermediate product;

[0053] S4, adding 50g of the intermediate product in step S3 to 800g of deionized water, followed by adding 30g of glycerol, 5g of 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and 0.5g of pyridine, and reacting at 80°C for 8h under a nitrogen atmosphere. After the reaction is completed, 4 times the volume of dichloromethane is added for precipitation, filtered, washed with anhydrous ethanol 3 times, and dried at 80°C for 4h to obtain the modified dextrin.

[0054] Example 3

[0055] A method for preparing a stable composition containing polydatin comprises the following steps:

[0056] 30 g of polydatin was added to 80 mL of ethanol and stirred to dissolve to obtain a polydatin solution; 50 g of modified dextrin was added to 600 mL of deionized water and stirred to dissolve to obtain a modified dextrin solution; the polydatin solution was then added to the modified dextrin solution, ultrasonically treated at a power of 200 W for 20 minutes, stirred at 60° C. for 3 hours after the treatment, cooled to room temperature after the stirring was completed, 7 g of urea and 30 g of tea polyphenols were added, stirred evenly, concentrated under reduced pressure at 50 kPa and 80° C. to 1 / 3 of the volume, and freeze-dried to obtain the stable composition containing polydatin.

[0057] Wherein, the preparation method of the modified dextrin is as follows:.

[0058] S1. Add 10 g of β-cyclodextrin to 1 L of deionized water, add 0.8 mol / L sodium hydroxide solution to adjust the pH to 12, react at 55°C for 2 h, add acetone to precipitate after the reaction is complete, centrifuge and filter, wash with anhydrous ethanol three times, and dry at 80°C for 5 h to obtain pretreated β-cyclodextrin;

[0059] S2, adding 50g of pretreated β-cyclodextrin in step S1 to 1L N, N-dimethylformamide, followed by adding 40g of succinic anhydride and 10g of p-toluenesulfonic acid, stirring and reacting at 85°C for 3h, adding 4 times the volume of dichloromethane to precipitate after the reaction is completed, filtering, washing with anhydrous ethanol 3 times, and drying at 80°C for 4h to obtain carboxylated β-cyclodextrin;

[0060] S3, adding 50g of carboxylated β-cyclodextrin in step S2 to 800g of thionyl chloride, reacting at 75°C for 6h, and removing thionyl chloride by rotary evaporation after the reaction is completed to obtain an intermediate product;

[0061] S4, adding 50g of the intermediate product in step S3 to 1000g of deionized water, followed by adding 40g of glycerol, 9g of 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and 1g of pyridine, and reacting at 90°C for 5h under a nitrogen atmosphere. After the reaction is completed, 4 times the volume of dichloromethane is added for precipitation, filtered, washed with anhydrous ethanol 3 times, and dried at 80°C for 4h to obtain the modified dextrin.

[0062] Comparative Example 1

[0063] A method for preparing a stable composition containing polydatin comprises the following steps:

[0064] 15 g of polydatin was added to 80 mL of ethanol and stirred to dissolve to obtain a polydatin solution; 30 g of modified dextrin was added to 400 mL of deionized water and stirred to dissolve to obtain a modified dextrin solution; the polydatin solution was then added to the modified dextrin solution, ultrasonically treated at a power of 200 W for 20 minutes, stirred at 55° C. for 3.5 hours after the treatment, cooled to room temperature after the stirring was completed, 15 g of urea and 45 g of tea polyphenols were added, stirred evenly, concentrated under reduced pressure at 50 kPa and 80° C. to 1 / 3 of the volume, and freeze-dried to obtain the stable composition containing polydatin.

[0065] Wherein, the preparation method of the modified dextrin is as follows:.

[0066] S1. Add 10 g of β-cyclodextrin to 1 L of deionized water, add 0.6 mol / L sodium hydroxide solution to adjust the pH to 12, and react at 50°C for 2.5 hours. After the reaction is complete, add acetone to precipitate, centrifuge and filter, wash with anhydrous ethanol three times, and dry at 80°C for 5 hours to obtain pretreated β-cyclodextrin;

[0067] S2. Add 50g of pretreated β-cyclodextrin in step S1 to 1L N,N-dimethylformamide, then add 35g of succinic anhydride and 8g of p-toluenesulfonic acid, and stir the reaction at 80°C for 3.5h. After the reaction is completed, add 4 times the volume of dichloromethane for precipitation, filter, wash with anhydrous ethanol 3 times, and dry at 80°C for 4h to obtain modified dextrin.

[0068] Comparative Example 2

[0069] A method for preparing a stable composition containing polydatin comprises the following steps:

[0070] 15 g of polydatin was added to 80 mL of ethanol and stirred to dissolve to obtain a polydatin solution; 30 g of β-cyclodextrin was added to 2 L of deionized water and stirred to dissolve to obtain a pretreated dextrin solution; the polydatin solution was then added to the modified dextrin solution, ultrasonically treated at a power of 200 W for 20 minutes, stirred at 55° C. for 3.5 hours after the treatment, cooled to room temperature after the stirring was completed, 15 g of urea and 45 g of tea polyphenols were added, stirred evenly, concentrated under reduced pressure at 50 kPa and 80° C. to 1 / 3 of the volume, and freeze-dried to obtain the stable composition containing polydatin.

[0071] Wherein, the preparation method of the pretreated dextrin is as follows:.

[0072] 10 g of β-cyclodextrin was added to 1 L of deionized water, and a sodium hydroxide solution with a concentration of 0.6 mol / L was added to adjust the pH to 12. The mixture was reacted at 50 ° C for 2.5 h. After the reaction was completed, acetone was added for precipitation, centrifuged and filtered, washed with anhydrous ethanol three times, and dried at 80 ° C for 5 h to obtain pretreated dextrin.

[0073] The performance of the stable compositions containing polydatin prepared in Examples 1-3 and Comparative Examples 1-2 was tested. The specific test method for free radical scavenging rate was as follows: 2.0 mL of a 0.2 mmol / L -1 DPPH·ethanol solution was placed in a test tube, and 2 mL of the solution of the composition of Example 1-3 and Comparative Example 1-2 was added to the solution at a concentration of 15 mg / mL. The mixture was quickly mixed and placed in a 37°C constant temperature water bath in the dark for 60 minutes. The absorbance (A1) was then immediately measured at a wavelength of 517 nm. At the same time, 2 mL of the sample solution of Example 1-3 and Comparative Example 1-2 (at a concentration of 15 mg / mL) was added to 2 mL of anhydrous ethanol to measure the absorbance (A2). In addition, 2 mL of anhydrous ethanol was taken instead of the composition solution and 2 mL of DPPH free radical solution was added to measure the blank absorbance (A o ). DPPH clearance rate was calculated according to the following formula.

[0074]

[0075] Each composition (1 g) was subjected to 20 J / cm 2 The free radical scavenging rate of each group was tested again after irradiation with ultraviolet light. The test results are shown in Table 1:

[0076] Table 1

[0077] Free radical scavenging rate / % Free radical scavenging rate after irradiation / % Example 1 92.8 88.3 Example 2 90.7 85.8 Example 3 96.4 92.2 Comparative Example 1 83.1 68.2 Comparative Example 2 75.9 61.5

[0078] As can be seen from Table 1 above, the stable composition containing polydatin prepared by the present invention has good solubility and light stability, which may be because the modified dextrin makes polydatin dissolve more, thereby improving the free radical scavenging rate of the composition, and the free radical scavenging rate of the stable composition of the present invention decreases less after ultraviolet irradiation, and has good application prospects.

[0079] The stable composition containing polydatin prepared in Example 1 and Comparative Examples 1-2 was applied to lotion. The specific ingredients are shown in Table 2 below:

[0080] Table 2

[0081]

[0082]

[0083] According to Table 2 above, the skin on the back of the hand is used as the test point, and after quantitative application and absorption in a fixed area, the skin moisture content is tested. In the same time, the stable composition containing polydatin prepared by the present invention has better moisturizing effect when applied to lotion.

[0084] The stability test involved placing the resulting compositions in transparent glass bottles and storing them at 4°C for one month. After one month, the appearance of the liquid was visually inspected and evaluated according to the following criteria: Good: no crystal particles observed; Fair: few crystal particles observed; Poor: many crystal particles observed. The stable polydatin-containing compositions prepared by the present invention exhibited good stability when used in lotions.

[0085] The stable composition containing polydatin prepared in Example 1 and Comparative Examples 1-2 was applied to the essence. The specific ingredients are shown in Table 3 below:

[0086] Table 3

[0087]

[0088]

[0089] It can be seen from Table 3 that the stable composition containing polydatin prepared by the present invention has better moisturizing effect when applied to essence, and the stable composition containing polydatin prepared by the present invention has good stability when applied to essence.

[0090] The stable composition containing polydatin prepared in Example 1 and Comparative Examples 1-2 was applied to a facial cream. The specific ingredients are shown in Table 4 below:

[0091] Table 4

[0092]

[0093]

[0094] It can be seen from Table 4 that the stable composition containing polydatin prepared by the present invention has better moisturizing effect when applied to facial cream, and the stable composition containing polydatin prepared by the present invention has good stability when applied to facial cream.

[0095] The above content is a further detailed description of the present invention in combination with specific implementation examples. It cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, they can make several simple deductions or substitutions without departing from the concept of the present invention, which should be regarded as falling within the scope of protection of the present invention.

[0096] It will be easily understood by those skilled in the art that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A stable composition comprising polydatin, characterized in that: Calculated by weight, it includes the following raw materials: 8-30 parts of polydatin, 30-60 parts of tea polyphenols, 7-20 parts of urea, and 20-50 parts of modified dextrin; The preparation method of the modified dextrin comprises the following steps: S1, adding β-cyclodextrin to deionized water, adding sodium hydroxide solution to adjust the pH to 11-12, and performing activation reaction. After the reaction is completed, adding acetone to precipitate, filtering, washing, and drying to obtain pretreated β-cyclodextrin; S2, adding the pretreated β-cyclodextrin in step S1 to N,N-dimethylformamide, followed by adding succinic anhydride and p-toluenesulfonic acid, stirring to react, adding dichloromethane to precipitate after the reaction is completed, filtering, washing, and drying to obtain carboxylated β-cyclodextrin; S3, adding thionyl chloride to the carboxylated β-cyclodextrin in step S2, heating the mixture to react, and removing the thionyl chloride by rotary evaporation after the reaction is completed to obtain an intermediate product; S4. Add the intermediate product in step S3 into deionized water, then add glycerol, 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and pyridine, and react at a constant temperature under a nitrogen atmosphere. After the reaction is completed, add dichloromethane to precipitate, filter, wash, and dry to obtain the modified dextrin.

2. The stable composition comprising polydatin according to claim 1, characterized in that Calculated by weight, it includes the following raw materials: 10-25 parts of polydatin, 40-50 parts of tea polyphenols, 8-16 parts of urea, and 25-40 parts of modified dextrin.

3. The stable composition comprising polydatin according to claim 1, characterized in that Calculated by weight, it includes the following raw materials: 15-20 parts of polydatin, 45-50 parts of tea polyphenols, 9-12 parts of urea, and 25-30 parts of modified dextrin.

4. The stable composition comprising polydatin according to claim 1, characterized in that The concentration of the sodium hydroxide solution in step S1 is 0.4-0.8 mol / L, the temperature of the activation reaction is 45-55° C., and the reaction time is 2-3 h.

5. The stable composition comprising polydatin according to claim 1, characterized in that In step S2, the mass ratio of the pretreated β-cyclodextrin, succinic anhydride, and p-toluenesulfonic acid is 50:30-40:5-10; the stirring reaction temperature is 75-85° C., and the time is 3-4 hours.

6. The stable composition comprising polydatin according to claim 1, characterized in that In step S3, the mass ratio of the carboxylated β-cyclodextrin to thionyl chloride is 50:600-800, the temperature of the heating reaction is 70-75° C., and the reaction time is 6-10 h.

7. The stable composition comprising polydatin according to claim 1, characterized in that In step S4, the mass ratio of the intermediate product, glycerol, 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone, and pyridine is 50:30-40:5-9:0.5-1, and the isothermal reaction temperature is 80-90° C. and the reaction time is 5-8 h.

8. A method for preparing a stable composition comprising polydatin according to any one of claims 1 to 7, characterized in that: The following steps are involved: Adding polydatin into ethanol and stirring to dissolve to obtain polydatin solution; The modified dextrin is added to deionized water and stirred to dissolve to obtain a modified dextrin solution; then the polydatin solution is added to the modified dextrin solution and ultrasonically treated. After the treatment, the solution is stirred at 50-60°C for 3-4 hours. After the stirring is completed, the solution is cooled to room temperature, urea and tea polyphenols are added, the solution is stirred evenly, and then the solution is concentrated under reduced pressure and freeze-dried to obtain the stable composition containing polydatin.

Images