A microfluidic device capable of achieving segmented sweat collection during exercise

Abstract

The present invention provides a microfluidic device capable of achieving time-segmented sweat collection during exercise, comprising: a microfluidic chip, at least two sweat collection microchannels are constructed in the microfluidic chip, a sweat collection hole is formed on the first end surface of the microfluidic chip, each sweat collection microchannel includes a sweat inflow control pipe section and a sweat storage pipe section that are sequentially connected, each sweat inflow control pipe section is located on the pore wall of the sweat collection hole, the end of each sweat storage pipe section has an exhaust port, a breathable and waterproof film is arranged in the exhaust port, and the flow diameters of the sweat inflow control pipe sections respectively possessed by each sweat collection microchannel are not equal. The present invention realizes that sweat can sequentially enter the corresponding sweat collection microchannels as time progresses, thereby achieving the purpose of time-segmented and sequential collection and storage of sweat; during the collection process, no manual intervention is required, the sweat collection efficiency is higher, and the pollution risk brought by manual intervention is eliminated, ensuring the original properties of the sweat in each microchannel.

Description

[0001] This invention was completed with the funding support of the following projects: "Special Fund for the Development of Clinical Medicine of Beijing Hospital Administration Center in 2023 (ZLRK202308)" and "Research Project of the Emerging Interdisciplinary Platform of Sports Medicine Engineering". Technical Field

[0002] This invention belongs to the technical field of microfluidic biochip design, and specifically relates to a microfluidic device that can collect sweat in segments during exercise. Background Art

[0003] Microfluidics is an interdisciplinary technical field that studies the flow and control of liquids at the micron or nanometer scale. It combines the principles and methods of physics, chemistry, biology, and engineering, aiming to manipulate trace amounts of liquids or gases using microchannels and microdevices, and is widely applied in fields such as biochemical analysis, drug screening, and biosensors.

[0004] Since sweat contains key information about human health and exercise status, the technology for collecting sweat during exercise has become increasingly important. Traditional sweat collection methods are divided into whole-body collection methods and local collection methods. Whole-body collection methods include whole-body rinsing and collecting soaked clothing, etc.; local collection methods include sweat patches, gauze sponges, filter papers, plastic sweat collectors, etc. The sweat collected by the whole-body collection method is easily contaminated by substances on the skin surface and clothing, and the operation is very cumbersome; the local collection method is relatively easier to operate, but since the collected sweat is in direct contact with the external environment, there is still a high risk of contamination; neither of the above two methods can collect and store sweat in segments, which will also lead to the mixing of new and old sweat, and also cause the "contamination" of sweat. Summary of the Invention

[0005] Therefore, the technical problem to be solved by this invention is to provide a microfluidic device that can collect sweat in segments during exercise, which can solve the technical problems of low collection efficiency and high contamination risk existing in the traditional sweat collection methods in the prior art.

[0006] To solve the above problems, this invention provides a microfluidic device that can collect sweat in segments during exercise, including:

[0007] A microfluidic chip, in which at least two sweat collection microchannels are constructed. A sweat collection hole is formed on the first end face of the microfluidic chip. Each of the sweat collection microchannels includes a sweat inflow control pipe segment and a sweat storage pipe segment that are connected in sequence. Each of the sweat inflow control pipe segments is located on the pore wall of the sweat collection hole. The end of each sweat storage pipe segment has an exhaust port, and a breathable and water-impermeable film is provided in the exhaust port. The flow-through diameters of the sweat inflow control pipe segments respectively provided in each of the sweat collection microchannels are not equal;

[0008] A fixing structure for fixedly connecting the first end face of the microfluidic chip to a target position on the user's skin.

[0009] In some embodiments, the sweat inflow control pipe segments respectively provided in each of the sweat collection microchannels are uniformly spaced around the sweat collection hole, and along the circumferential direction of the sweat collection hole, the flow-through diameters of the sweat inflow control pipe segments increase in sequence.

[0010] In some embodiments, the flow-through diameters and the total lengths of the pipe segments of the sweat storage pipe segments are equal, and the flow-through diameters of each of the sweat inflow control pipe segments are smaller than the flow-through diameters of the sweat storage pipe segments.

[0011] In some embodiments, the flow-through diameters of each of the sweat inflow control pipe segments form an arithmetic progression with a common difference of d, 0.1 mm ≤ d ≤ 0.5 mm, and the flow-through diameter of the smallest sweat inflow control pipe segment is d1, 0.05 mm ≤ d ≤ 0.2 mm, and the flow-through diameter of the largest sweat inflow control pipe segment is d2, 1 mm ≤ d ≤ 2 mm; and / or, the extension length of each of the sweat inflow control pipe segments is s, 2 mm ≤ s ≤ 5 mm.

[0012] In some embodiments, the flow-through diameter of the sweat storage pipe segment is D, 0.2 mm ≤ D ≤ 0.5 mm.

[0013] In some embodiments, the total length of the pipe segment extension of the sweat storage pipe segment is L, 50 mm ≤ L ≤ 150 mm.

[0014] In some embodiments, each of the sweat inflow control pipe segments extends radially outward from the inside to the outside of the microfluidic chip, and each of the sweat storage pipe segments is arranged in a coiled manner in the fan-shaped area on the radial outer side of the microfluidic chip; and / or,

[0015] The microfluidic chip includes a chip body and a sealing film. Each of the sweat collection microchannels is formed on the second end face of the chip body, and the sealing film is hermetically covered and connected to the second end face to form a seal for each of the sweat collection microchannels, and the exhaust port is formed on the sealing film.

[0016] In some embodiments, an identifier is provided on the outer surface of the sealing film, and the identifier can indicate the collection time sequence of each of the sweat collection micro-channels.

[0017] In some embodiments, the fixing structure is double-sided tape. One side of the double-sided tape is adhered to the first end face, and a hollowed-out hole is formed in the central region of the double-sided tape, and the sweat collection hole is located within the hollowed-out hole.

[0018] In some embodiments, a plurality of air-permeable grooves extending radially from the inside to the outside are formed on the side of the double-sided tape away from the first end face, and each of the air-permeable grooves is disposed around the outer peripheral side of the hollowed-out hole.

[0019] A microfluidic device provided by the present invention can achieve time-segmented sweat collection during exercise. By constructing at least two sweat collection micro-channels in the microfluidic chip and the flow-through diameters of the sweat inflow control pipe segments respectively provided for each of the sweat collection micro-channels being unequal, different sweat entry resistances are created in each of the sweat inflow control pipe segments, so that sweat can enter the corresponding sweat collection micro-channels sequentially as time progresses, thereby achieving the purpose of time-sharing and sequential collection and storage of sweat; sweat collection is achieved by relying on the self-pressure of the sweat in the sweat collection hole, and no manual intervention is required during the collection process. Therefore, the sweat collection efficiency is higher, and the pollution risk brought by manual intervention is eliminated, ensuring the original properties of the sweat in each micro-channel and providing high-quality samples for further omics analysis; in addition, it should be particularly emphasized that each of the sweat collection micro-channels in the present invention is independent of each other and is collected and stored sequentially over time, that is, sequential filling of each of the sweat collection micro-channels is achieved, ensuring that the sweat sample within a specific time period is preserved in each micro-channel, effectively preventing the contact between new and old sweat and thus avoiding the neutralization of the sweat component concentration, providing temporal continuity and diversity for subsequent omics analysis. Description of the Drawings

[0020] Figure 1 is an exploded structural schematic diagram of the microfluidic device capable of achieving time-segmented sweat collection during exercise according to an embodiment of the present invention;

[0021] Figure 2 is Figure 1 a top view (showing each sweat collection micro-channel) of the chip body in ;

[0022] Figure 3 is Figure 2 a partial structural schematic diagram of ;

[0023] Figure 4 is Figure 1 a bottom view of the microfluidic device capable of achieving time-segmented sweat collection during exercise in in an embodiment;

[0024] Figure 5 The Figure 1 bottom view of the fixed structure in one embodiment;

[0025] Figure 6 Schematic diagram of the sweat collection state of a sweat collection micro-channel in a microfluidic device capable of achieving segmented sweat collection during exercise according to the present invention within a period of time;

[0026] Figure 7 Schematic diagram of the segmented sweat collection states of each sweat collection micro-channel in the microfluidic device capable of achieving segmented sweat collection during exercise according to the present invention.

[0027] The reference numerals are shown as:

[0028] 1. Microfluidic chip; 11. Sweat collection micro-channel; 111. Sweat inflow control pipe section; 112. Exhaust port; 113. Sweat storage pipe section; 12. Sweat collection hole; 2. Breathable and water-impermeable film; 3. Fixed structure; 31. Perforation; 32. Ventilation groove; 101. Chip body; 102. Sealing film. Detailed implementation manners

[0029] Referring to Figures 1 to 7 shown in the figure, according to an embodiment of the present invention, there is provided a microfluidic device capable of achieving segmented sweat collection during exercise, including:

[0030] A microfluidic chip 1, at least two sweat collection micro-channels 11 are constructed inside the microfluidic chip 1, a sweat collection hole 12 is formed on the first end surface of the microfluidic chip 1, each sweat collection micro-channel 11 includes a sweat inflow control pipe section 111 and a sweat storage pipe section 113 that are connected in sequence, each sweat inflow control pipe section 111 is located on the pore wall of the sweat collection hole 12, the end of each sweat storage pipe section 113 has an exhaust port 112, a breathable and water-impermeable film 2 is provided inside the exhaust port 112, the through-flow diameters of the sweat inflow control pipe sections 111 respectively provided by each sweat collection micro-channel 11 are not equal, and the unequal through-flow diameters can make different sweat entry resistances be formed in the manufacturing of each sweat inflow control pipe section 111, so as to achieve the purpose that sweat can enter the corresponding sweat collection micro-channel 11 in sequence as time goes by;

[0031] The fixing structure 3 is used to fixedly connect the first end face of the microfluidic chip 1 to the target position on the user's skin. The aforementioned target position can be, for example, positions such as the neck, chest, abdomen, arm, thigh, etc. of users such as athletes. The aforementioned breathable and waterproof film 2 can specifically adopt PTFE material, which blocks water when encountering water and maintains good breathability before not encountering water. Other similar materials can also be used, such as waterproof and breathable membranes, microporous membranes, etc.

[0032] In this technical solution, at least two sweat collection microchannels 11 are constructed in the microfluidic chip 1, and the flow-through diameters of the sweat inflow control pipe segments 111 respectively possessed by the sweat collection microchannels 11 are not equal. Therefore, different sweat entry resistances are created for the sweat inflow control pipe segments 111, and then sweat can enter the corresponding sweat collection microchannels 11 successively over time, thereby achieving the purpose of collecting and storing sweat in a time-sharing and sequential manner; sweat collection is achieved by relying on the self-pressure of the sweat in the sweat collection holes 12, and no manual intervention is required during the collection process. Therefore, the sweat collection efficiency is higher, and the pollution risk brought by manual intervention is eliminated, ensuring the original nature of the sweat in each microchannel and providing high-quality samples for further omics analysis; in addition, it should be particularly emphasized that each sweat collection microchannel 11 in the present invention is independent of each other and successively collects and stores over time, that is, successive filling of each sweat collection microchannel 11 is achieved, ensuring that the sweat samples within a specific time period are stored in each microchannel, effectively preventing the contact between new and old sweat and thus avoiding the neutralization of sweat component concentrations, providing temporal continuity and diversity for subsequent omics analysis.

[0033] Specifically, the smaller the flow-through diameter of the sweat inflow control pipe segment 111, the greater the sweat entry resistance, and the larger the flow-through diameter, the smaller the sweat entry resistance. Thus, when the microfluidic device of the present invention is fixed to the target position on the user's skin, as the user moves, the sweat glands in the skin at the target position will secrete sweat, and the secreted sweat will enter the aforementioned sweat collection holes 12. The sweat glands secrete continuously over time, and the sweat will gradually increase the pressure in the sweat collection holes 12. At this time, the sweat will preferentially enter the corresponding sweat collection microchannel 11 from the sweat inflow control pipe segment 111 with the smallest resistance (i.e., the largest flow-through diameter). When the sweat in the microchannel is collected to the end of the pipe, i.e., the exhaust port 112, it will encounter the breathable and waterproof film 2 and seal this microchannel. After that, the sweat will enter each microchannel successively according to the flow-through diameters of the sweat inflow control pipe segments 111 from large to small, and continuous and time-segmented collection of sweat can be achieved without manual intervention.

[0034] It should be particularly emphasized that each of the aforementioned sweat inflow control pipe segments 111 utilizes the capillary valve principle (which can also be called the capillary rupture valve principle), and its resistance is related to the size of the corresponding pipe. Generally speaking, the thinner the pipe (branch), the greater its resistance. Therefore, the design of the present invention can intelligently guide sweat to the pipe (branch) with less resistance.

[0035] It should be noted that the sweat samples collected by the microfluidic device of the present invention can be subjected to omics analysis, including but not limited to the detection of various aspects such as proteins and metabolites. Such analysis can deeply understand the physiological state of athletes at different exercise times, providing detailed and comprehensive information for sports health management and scientific training; based on the results of omics analysis, scientific training plans can be customized for athletes, because these plans will be more personalized and accurately adapted to the physiological characteristics and changes of athletes.

[0036] As Figure 2 shown, in a specific embodiment, a total of four sweat collection micro-pipes 11 are designed, and the four sweat collection micro-pipes 11 are arranged at equal intervals around the aforementioned sweat collection hole 12.

[0037] In some embodiments, the sweat inflow control pipe segments 111 respectively provided in each of the sweat collection micro-pipes 11 are arranged at uniform intervals around the sweat collection hole 12, and along the circumferential direction of the sweat collection hole 12, the through-flow diameters of the respective sweat inflow control pipe segments 111 increase in sequence. For specific reference, see Figure 2 shown, a total of four sweat collection micro-pipes 11 are formed on the microfluidic chip 1. The through-flow diameters of the sweat inflow control pipe segments 111 respectively provided in each of the sweat collection micro-pipes 11 increase in sequence along the clockwise direction, so as to facilitate the judgment of the sequence of different time periods and prevent the confusion of sweat samples collected at different time periods during the subsequent component analysis process. In a specific embodiment, see Figure 7 shown, the through-flow diameter of the sweat inflow control pipe segment 111 at the six o'clock position in the figure is the largest, and the through-flow diameter decreases in sequence along the counterclockwise direction. The through-flow diameter of the sweat inflow control pipe segment 111 at the nine o'clock position in the figure is the smallest.

[0038] In some embodiments, the through-flow diameters and the total lengths of the pipe segments of the sweat storage pipe segments 113 are all equal, and the through-flow diameters of the respective sweat inflow control pipe segments 111 are all smaller than the through-flow diameters of the sweat storage pipe segments 113. That is to say, the through-flow diameters of the respective sweat storage pipe segments 113 are larger than the corresponding sweat inflow control pipe segments 111. In this way, it can be ensured that sweat can more smoothly fill the corresponding sweat storage pipe segment 113 after entering the sweat inflow control pipe segment 113. It can be understood that after sweat enters the corresponding micro-pipe, the air inside will be discharged through the aforementioned exhaust port 112.

[0039] It can be understood that when the cross-section of each pipe segment is circular, the aforementioned flow-through diameter is the diameter of the corresponding circle. When the cross-section of each pipe segment is of other shapes, the aforementioned flow-through diameters are respectively the diameters of circles converted to the corresponding flow-through areas, that is, the equivalent diameters. In a specific embodiment, the cross-sections of the aforementioned pipe segments are circular.

[0040] In some embodiments, the flow-through diameters of the sweat inflow control pipe segments 111 form an arithmetic progression with a common difference of d, where 0.1 mm ≤ d ≤ 0.5 mm, and the flow-through diameter of the smallest sweat inflow control pipe segment 111 is d1, where 0.05 mm ≤ d ≤ 0.2 mm, and the flow-through diameter of the largest sweat inflow control pipe segment 111 is d2, where 1 mm ≤ d ≤ 2 mm. To ensure the effectiveness of the time-sharing and successive control of sweat by each sweat inflow control pipe segment 111, the selection of the aforementioned d value can effectively prevent the possibility of two sweat inflow control pipe segments 111 entering sweat simultaneously.

[0041] In a preferred embodiment, the extension length of each sweat inflow control pipe segment 111 is s, where 2 mm ≤ s ≤ 5 mm. If it is shorter than the aforementioned range, it may result in too little sweat collected in the pipeline, not meeting the minimum sample volume requirements of methods such as mass spectrometry detection. If the pipeline is too long, it may lead to an increase in the resistance to pushing the sweat towards the end of the pipeline, increasing the difficulty of sweat collection and possibly causing confusion in the collection order of each control pipeline. The flow-through diameter of the sweat storage pipe segment 113 is D, where 0.2 mm ≤ D ≤ 0.5 mm, which can ensure that the sweat entering the corresponding sweat inflow control pipe segment 111 can flow more smoothly into the sweat storage pipe segment 113. The total extension length of the sweat storage pipe segment 113 is L, where 50 mm ≤ L ≤ 150 mm. To make the sweat filling process more stable, it is preferred to perform different degrees of hydrophobic treatment in each sweat inflow control pipe segment 111.

[0042] In some embodiments, each sweat inflow control pipe segment 111 extends radially outward from the inside to the outside along the microfluidic chip 1, and each sweat storage pipe segment 113 is arranged in a coiled manner in the fan-shaped area outside the radial direction of the microfluidic chip 1. As Figure 2 described, each sweat storage pipe segment 113 extends and is arranged in a zigzag manner from the inside to the outside along the radial direction of the microfluidic chip 1. In this way, while ensuring that each sweat storage pipe segment 113 has sufficient storage capacity, the overall size of the microfluidic device can be reduced as much as possible, thereby ensuring that it can be fixed to a smaller skin area and having better portability.

[0043] See specifically Figure 1As shown, the microfluidic chip 1 includes a chip body 101 and a sealing film 102. Each of the sweat collection micro-channels 11 is formed on the second end face of the chip body 101. At this time, each sweat collection micro-channel 11 has an opening on the second end face, and the sealing film 102 is hermetically covered and connected to the second end face to form a seal for each of the sweat collection micro-channels 11, that is, the sealing film 102 seals the aforementioned opening. The exhaust port 112 is formed on the sealing film 102, and the aforementioned breathable and waterproof film 2 is pasted at the position of the exhaust port 112 of the sealing film 102.

[0044] In this technical solution, after each sweat collection micro-channel 11 is formed on the second end face of the chip body 101 in the form of an open groove and then the sealing film 102 seals the aforementioned opening, the manufacturing difficulty of the micro-channel can be significantly reduced. The aforementioned sealing film 102 is, for example, pasted on the aforementioned second end face. Specifically, the aforementioned sealing film 102 has single-sided adhesive and has good waterproof performance, and is used to seal each of the sweat collection micro-channels 11.

[0045] It should be noted that the combination of the aforementioned exhaust port 112 and the breathable and waterproof film 2 not only effectively prevents external pollutants from entering the microfluidic chip 1, but also ensures that the gas inside the micro-channel can be quickly and instantaneously discharged during the flow process. This enables the microfluidic chip 1 to collect sweat more effectively during movement, reduces the possible air resistance during sweat collection, improves the collection efficiency, and at the same time maintains the accuracy and stability of the collection.

[0046] In a preferred embodiment, the outer surface of the sealing film 102 has markings (not shown in the figure), and the markings can indicate the collection sequence of each of the sweat collection micro-channels 11. The aforementioned markings can be, for example, simple Arabic numerals, or other markings that can indicate the time sequence.

[0047] The fixing structure 3 is double-sided adhesive. One side of the double-sided adhesive is pasted to the first end face, and a through hole 31 is formed in the central area of the double-sided adhesive. The sweat collection hole 12 is located within the through hole 31. The double-sided adhesive has good adhesiveness and sealing performance, and at the same time has reliable biocompatibility and breathability, and hardly feels when stuck to the human skin, thereby improving the comfort of using the device. In addition, it should be particularly noted that using double-sided adhesive as the fixing structure 3 can further compact the structural design of the microfluidic device and make it more convenient to use.

[0048] In some embodiments, a plurality of air permeation grooves 32 extending radially from the inside to the outside are formed on the surface of the double-sided adhesive away from the first end face. Each of the air permeation grooves 32 is disposed around the outer peripheral side of the perforation 31. That is, by providing the aforementioned air permeation grooves 32 in the area where the double-sided adhesive is adhered to the skin, the comfort of the user wearing the microfluidic device of the present invention can be further improved.

[0049] The microfluidic device proposed by the present invention, which can achieve time-segmented sweat collection during exercise, provides a brand-new means for sports health management and training. The combination of its sequential sweat collection and omics analysis will provide more scientific and personalized training suggestions for athletes, further promoting the technological development in the field of sports health.

[0050] It is easy for those skilled in the art to understand that, on the premise of no conflict, the above-mentioned advantageous manners can be freely combined and superimposed.

[0051] The above are only the preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention. The above is only the preferred implementation manner of the present invention. It should be noted that for those of ordinary skill in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as within the protection scope of the present invention.

Claims

1. A microfluidic device capable of achieving segmented sweat collection during exercise, characterized in that, Comprising: A microfluidic chip (1), at least two sweat collection microchannels (11) are constructed inside the microfluidic chip (1), a sweat collection hole (12) is formed on the first end face of the microfluidic chip (1), each of the sweat collection microchannels (11) includes a sweat inflow control pipe segment (111) and a sweat storage pipe segment (113) that are connected in sequence, each of the sweat inflow control pipe segments (111) is located on the pore wall of the sweat collection hole (12), the end of each sweat storage pipe segment (113) has an exhaust port (112), a breathable and water-impermeable film (2) is provided in the exhaust port (112), the flow-through diameters of the sweat inflow control pipe segments (111) respectively possessed by each of the sweat collection microchannels (11) are not equal, the sweat inflow control pipe segments (111) respectively possessed by each of the sweat collection microchannels (11) are arranged at equal intervals around the sweat collection hole (12), and along the circumferential direction of the sweat collection hole (12), the flow-through diameters of each of the sweat inflow control pipe segments (111) increase in sequence; A fixing structure (3) for fixedly connecting the first end face of the microfluidic chip (1) to a target position on the user's skin.

2. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 1, wherein The flow-through diameters and the total pipe segment extension lengths of the sweat storage pipe segments (113) are all equal, and the flow-through diameters of each of the sweat inflow control pipe segments (111) are all smaller than the flow-through diameters of the sweat storage pipe segments (113).

3. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 2, wherein The flow-through diameters of each of the sweat inflow control pipe segments (111) form an arithmetic progression with a common difference of d, 0.1mm ≤ d ≤ 0.5mm, and the flow-through diameter of the smallest sweat inflow control pipe segment (111) is d1, 0.05mm ≤ d1 ≤ 0.2mm, the flow-through diameter of the largest sweat inflow control pipe segment (111) is d2, 1mm ≤ d2 ≤ 2mm; and / or, the extension length of each of the sweat inflow control pipe segments (111) is s, 2mm ≤ s ≤ 5mm.

4. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 3, characterized in that, The total pipe segment extension length of the sweat storage pipe segments (113) is L, 50mm ≤ L ≤ 150mm.

5. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 1, characterized in that, Each of the sweat inflow control pipe segments (111) extends radially outward from the inside of the microfluidic chip (1) in a radial direction, and each of the sweat storage pipe segments (113) is arranged in a coiled manner within a fan-shaped area outside the radial direction of the microfluidic chip (1); and / or, The microfluidic chip (1) includes a chip body (101) and a sealing film (102), each of the sweat collection microchannels (11) is formed on the second end face of the chip body (101), and the sealing film (102) is hermetically covered and connected to the second end face to form a seal for each of the sweat collection microchannels (11), and the exhaust port (112) is formed on the sealing film (102).

6. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 5, wherein The outer surface of the sealing film (102) has markings, and the markings can indicate the collection time sequence of each of the sweat collection microchannels (11).

7. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 1, wherein The fixing structure (3) is a double-sided adhesive tape. One side of the double-sided adhesive tape is adhered to the first end face, and a hollowed-out hole (31) is formed in the central area of the double-sided adhesive tape. The sweat collection hole (12) is located within the hollowed-out hole (31).

8. The microfluidic device capable of achieving segmented sweat collection during exercise according to claim 7, wherein, A plurality of air-permeable grooves (32) extending radially from the inside to the outside are formed on the side of the double-sided adhesive tape away from the first end face, and each of the air-permeable grooves (32) is disposed around the outer peripheral side of the hollowed-out hole (31).

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