Grinding equipment for biological experimental materials

Abstract

The application relates to a kind of experimental material grinding equipment for biological experiment, belong to biological experiment equipment technical field, including base and the rotary power part being set on base, mortar is fixed on base, grinding head coaxial setting in mortar, the head of grinding head is opened with guide slot along its radial profile direction, flexible band is worn in guide slot, flexible band is provided with friction structure along its longitudinal direction, drive assembly includes two limit tubes and linear displacement mechanism, two limit tubes are fixed on grinding head, flexible band extends to corresponding limit tube in slide groove, the displacement output end of linear displacement mechanism is connected with both ends of flexible band, the application utilizes mortar, grinding head to carry out extrusion grinding, can drive flexible band reciprocating movement along guide slot simultaneously, so that friction structure is contacted with the friction force of biological tissue material along the radial direction of grinding head to the friction structure, realize the turning of biological tissue material, avoid the temperature of tissue material to be too high and cause the inactivation of target substance released.

Description

Technical Field

[0001] This invention belongs to the field of biological experimental equipment technology, specifically relating to a grinding device for experimental materials used in biological experiments. Background Technology

[0002] Biological experiments are the process of purposefully observing and studying the structure and life activities of organisms. When conducting experiments, it is necessary to grind the tissue material to break the tissue cells and release the target substances in the cells, such as proteins, enzymes and DNA.

[0003] When grinding biological tissue materials, researchers typically use a mortar and pestle with a matching grinding head. After placing the tissue material in the mortar, one hand holds the mortar down, while the other hand holds the grinding head against the tissue material in the mortar, and then manually rotates the grinding head. However, different researchers apply varying pressure to the tissue material with the grinding head when grinding manually, resulting in different degrees of cell rupture after grinding, making it difficult to standardize the grinding process.

[0004] Currently, existing technologies for standardized grinding of biological tissue materials employ grinding equipment. This equipment uses a frame to fix a mortar and pestle, into which the biological tissue material to be ground is introduced. A power mechanism then drives the grinding head to rotate, applying stable pressure to the tissue material, causing the tissue cells to rupture uniformly and thus obtaining the target substances within the tissue cells. However, biological tissue materials are mostly soft. When grinding with a power mechanism driving the grinding head, the tissue material is compacted, and the central portion cannot contact the inner wall of the mortar or the grinding head, requiring extended grinding time to rupture these cells. However, prolonged grinding leads to a continuous increase in the temperature of the tissue material. High temperatures can deactivate the initially released proteins, enzymes, and DNA, among other target substances. Summary of the Invention

[0005] In view of this, the present invention provides a grinding device for biological experimental materials, which ensures the grinding effect of biological tissue materials while avoiding excessive temperature that could cause the released target substances to become inactive, thereby overcoming the shortcomings of the prior art.

[0006] The technical solution of the present invention is: a grinding device for experimental materials in biological experiments, comprising a base and a rotating power unit disposed on the base, a mortar fixed on the base, a grinding head coaxially disposed in the mortar, the grinding head being connected to the rotation output shaft of the rotating power unit, a guide groove being formed at the head of the grinding head along its radial contour, a flexible belt passing through the guide groove, a friction structure being provided along the longitudinal direction of the flexible belt, and a driving component comprising two limiting tubes and a linear displacement mechanism, the two limiting tubes being fixed on the grinding head and located on both sides of the grinding head near the end of the guide groove, the flexible belt extending out of the groove into the corresponding limiting tube, the linear displacement mechanism being disposed on the limiting tube, the displacement output end of the linear displacement mechanism being connected to both ends of the flexible belt, for driving the flexible belt to reciprocate along the guide groove during grinding, so that the friction structure applies a frictional force along the radial direction of the grinding head to the biological tissue material in contact with it, thereby realizing the turning of the biological tissue material.

[0007] According to one embodiment of this disclosure, the friction structure employs any one of the following: a frosted layer, protrusions, and grooves. In this embodiment, the flexible belt has continuously formed grooves along its longitudinal direction. These grooves, on the one hand, utilize the pressure applied by the grinding head to ensure the groove openings adhere to the tissue material; on the other hand, the grooves amplify the pressure applied by the flexible belt to the tissue material during grinding, enhancing the friction between the grooves and the tissue material. This results in a better agitation effect on the tissue material from the movement of the flexible belt.

[0008] According to one embodiment of this disclosure, the guide groove extends from the side of the flexible band near the bottom of the mortar. In this embodiment, the protruding flexible band further enhances the adhesion between the flexible band and the tissue material, ensuring that the tissue material can be turned over when the flexible band moves.

[0009] According to one embodiment of this disclosure, the linear displacement mechanism includes a mortar lid and a hemisphere. The mortar lid is fastened to the mouth of the mortar and detachably fixedly connected to it. The plane of the hemisphere is fixedly connected to the inner side of the mortar lid. The hemisphere is located directly above the trajectory of the limiting tube as it rotates with the grinding head. The end of the flexible band abuts against the hemisphere when it passes through it. In this embodiment, the mortar lid separates from the mortar when biological tissue material is introduced, and is re-fastened and fixed after introduction. The end of the flexible band cooperates with the hemisphere during movement, allowing the flexible band to move along the limiting tube, thereby enabling the tissue material to be turned over throughout the grinding process, while avoiding the use of additional power components that would release heat.

[0010] According to one embodiment of this disclosure, the limiting tube is arc-shaped, and the two limiting tubes are arranged in an alternating pattern on the side away from the slide groove. In this embodiment, the arc-shaped limiting tubes arranged in an alternating pattern can move the tissue material present between the grinding head and the side wall of the mortar, actively pushing the tissue material back between the grinding head and the mortar.

[0011] According to one embodiment of this disclosure, there are multiple hemispheres, and the number is odd. The hemispheres are evenly spaced and fixed around the inner side of the bowl lid. The bowl lid has arc-shaped guide grooves between adjacent hemispheres, and the depth of the arc-shaped guide grooves gradually decreases near the end of the hemisphere. In this embodiment, the flexible belt moves in only one direction at a time, while multiple hemispheres enable the flexible belt to move back and forth at a high frequency. The rotation of the grinding head achieves the turning over of all the tissue material.

[0012] According to one embodiment of this disclosure, a sealing plate is fixedly provided at one end of the limiting tube near the bowl cover, and a guide rod is provided through the sealing plate. The guide rod is parallel to the limiting tube and is slidably connected to the sealing plate along its length extension direction. One end of the guide rod is connected to the end of the flexible strip, and a ball is fixedly provided at the other end. The ball abuts against the hemisphere when it passes through it.

[0013] In this embodiment, when the end of the flexible strip moves in the conduit, the sealing plate can effectively limit the direction of the guide rod's movement, so that the flexible strip can move stably using the guide rod and the ball.

[0014] According to one embodiment of this disclosure, a first spring is sleeved on the guide rod, one end of the first spring being connected to the end of the flexible strip, and the other end being connected to the sealing plate. In this embodiment, the first spring enables the flexible strip to quickly return to its original shape before the next movement, and the spring also enables the flexible strip to effectively turn over the tissue material while returning to its original shape.

[0015] According to one embodiment of this disclosure, a connecting shaft is provided through and slidably connected to the bowl cover. The connecting shaft is coaxial with the grinding head. One end of the connecting shaft is connected to the grinding head, and the other end is connected to the output shaft of the rotating power unit. A second spring is sleeved on the connecting shaft. One end of the second spring abuts against the bowl cover, and the other end abuts against the grinding head.

[0016] In this embodiment, a second spring is used to keep the grinding head pressing the tissue material, ensuring the speed of tissue cell rupture.

[0017] According to one embodiment of this disclosure, an externally threaded sleeve is provided on the bowl cover, the externally threaded sleeve being threadedly connected to the bowl cover, the connecting shaft passing through the externally threaded sleeve and slidably connected to it, the end of the second spring away from the grinding head abutting against the externally threaded sleeve, and a handwheel being fitted onto the end of the externally threaded sleeve located outside the bowl cover. In this embodiment, the experimenter manually rotates the externally threaded sleeve using the handwheel to adjust the axial position of the externally threaded sleeve, thereby adjusting the distance between the end of the externally threaded sleeve near the grinding head and the grinding head, and thus adjusting the pressure applied by the second spring to the grinding head.

[0018] Compared with existing technologies, the present invention provides a grinding device for biological experimental materials. The biological tissue material to be ground is contained in a mortar on a base. A rotating power unit drives the grinding head to rotate, compressing and grinding the biological tissue material. The grinding head utilizes a guide groove, a flexible belt, a friction structure, a limiting tube in the drive assembly, and a linear displacement mechanism. This allows the flexible belt to move back and forth along the guide groove, causing the friction structure to apply a radial frictional force to the biological tissue material in contact with it. This flips the biological tissue material, exposing the portion located in the middle of the compacted tissue material. Grinding can be completed in a shorter time, ensuring the grinding effect of the biological tissue material. Simultaneously, the flipping of the tissue material during grinding allows the heat generated during grinding to be released quickly, preventing the tissue material from overheating and causing the released target substance to become inactive. Attached Figure Description

[0019] Figure 1 This is a front view of the present invention;

[0020] Figure 2 This is a top view of the present invention;

[0021] Figure 3 This is a side view of the present invention;

[0022] Figure 4 This is a bottom view of the bowl lid of the present invention;

[0023] Figure 5 This is a cross-sectional view of the present invention (AA section).

[0024] Figure 6 This is a BB cross-sectional view of the present invention;

[0025] Figure 7 This is a CC cross-sectional view of the present invention;

[0026] Figure 8 This is a DD cross-sectional view of the present invention;

[0027] Figure 9 This is an enlarged schematic diagram of point E in the present invention;

[0028] Figure 10 This is a front view of the grinding head of the present invention;

[0029] Figure 11 This is a top view of the grinding head of the present invention. Detailed Implementation

[0030] This invention provides a grinding device for experimental materials used in biological experiments, which is described below in conjunction with... Figures 1 to 11 The present invention is illustrated by the structural diagram shown below.

[0031] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the technical solution of this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0032] Biological experiments are the process of purposefully observing and studying the structure and life activities of organisms. When conducting experiments, it is necessary to grind the tissue material to break the tissue cells and release the target substances in the cells, such as proteins, enzymes and DNA.

[0033] When grinding biological tissue materials, researchers typically use a mortar and pestle with a matching grinding head. After placing the tissue material in the mortar, one hand holds the mortar down, while the other hand holds the grinding head against the tissue material in the mortar, and then manually rotates the grinding head. However, different researchers apply varying pressure to the tissue material with the grinding head when grinding manually, resulting in different degrees of cell rupture after grinding, making it difficult to standardize the grinding process.

[0034] Currently, existing technologies for standardized grinding of biological tissue materials employ grinding equipment. This equipment uses a frame to fix a mortar and pestle, into which the biological tissue material to be ground is introduced. A power mechanism then drives the grinding head to rotate, applying stable pressure to the tissue material, causing the tissue cells to rupture uniformly and thus obtaining the target substances within the tissue cells. However, biological tissue materials are mostly soft. When grinding with a power mechanism driving the grinding head, the tissue material is compacted, and the central portion cannot contact the inner wall of the mortar or the grinding head, requiring extended grinding time to rupture these cells. However, prolonged grinding leads to a continuous increase in the temperature of the tissue material. High temperatures can deactivate the initially released proteins, enzymes, and DNA, among other target substances.

[0035] To address the aforementioned problems, this invention provides a grinding device for biological experimental materials. The device uses a mortar on a base to hold the biological tissue material to be ground. A rotating power unit drives the grinding head to rotate, compressing and grinding the biological tissue material. The grinding head utilizes a guide groove, a flexible belt, a friction structure, a limiting tube in the drive assembly, and a linear displacement mechanism. This allows the flexible belt to reciprocate along the guide groove, causing the friction structure to apply a radial frictional force to the biological tissue material in contact with it. This tumbles the biological tissue material, exposing the portion located in the middle of the compacted tissue material. Grinding can be completed in a shorter time, ensuring the grinding effect of the biological tissue material. Simultaneously, the tumbling of the tissue material during grinding allows for rapid release of the heat generated, preventing the target substance from becoming inactive due to excessively high temperatures. This grinding device is effective, easy to use, and highly practical, making it worthy of promotion.

[0036] As shown in the figure Figure 1 This is a front view of an experimental material grinding device for biological experiments, including a base 1 and a rotating power unit 2 disposed on the base 1. A mortar 3 is fixed on the base 1, and a grinding head 4 is coaxially disposed in the mortar 3. The grinding head 4 is connected to the rotation output shaft of the rotating power unit 2, as shown in the figure. Figure 5 This is a cross-sectional view (AA) of this embodiment. The head of the grinding head 4 has a guide groove 41 along its radial contour. The flexible belt 5 passes through the guide groove 41. The flexible belt 5 has a friction structure 51 along its longitudinal direction. The driving assembly includes two limiting tubes 6 and a linear displacement mechanism, as shown in the figure. Figure 7This is a CC cross-sectional view of this embodiment. Two limiting tubes 6 are fixed on the grinding head 4 and located on both sides of the grinding head 4 near the end of the guide groove 41. The flexible belt 5 extends out of the slide groove 41 and into the corresponding limiting tube 6. The linear displacement mechanism is set on the limiting tube 6. The displacement output end of the linear displacement mechanism is connected to both ends of the flexible belt 5. It is used to drive the flexible belt 5 to move back and forth along the guide groove 41 during grinding, so that the friction structure 51 applies a frictional force in the radial direction of the grinding head 4 to the biological tissue material in contact with it, so as to realize the flipping of the biological tissue material.

[0037] This embodiment of the invention discloses a grinding device for biological experimental materials. It utilizes a mortar 3 on a base 1 and a rotating power unit 2 to drive a grinding head 4 to rotate, thereby compressing and grinding the biological tissue material in the mortar 3. The biological tissue material is compressed and compacted by the grinding head 4. The portion of the tissue material located in the middle, unable to contact the inner wall of the mortar or the grinding head, is broken by the mutual compression of adjacent cells. Simultaneously, the grinding device utilizes a guide groove 41 on the grinding head 4 in conjunction with a flexible belt 5, a friction structure, a limiting tube of the driving component, and a linear displacement mechanism. This allows the flexible belt 5 to actively move within the limiting tube and guide groove. The friction structure, during the grinding process, tumbles the biological tissue material along the radial direction of the grinding head, exposing the portion of the tissue material located in the middle. This allows the tissue to come into contact with the grinding head 4, ensuring the grinding effect of the biological tissue material. This not only avoids the problem of needing to cool down due to prolonged grinding time, but also allows the tissue material to be turned over during grinding, enabling the heat generated during grinding to be released quickly. Existing natural heat dissipation methods allow heat to gradually diffuse from the inside of the tissue to the outside, and even when using heat dissipation equipment, the cooling is done from the outside to the inside, which is slow. When the temperature inside the tissue material rises rapidly, it can cause the released target substance to become inactive. In this embodiment, the natural heat dissipation effect is better than existing grinding methods. The tissue material is evenly turned over and exposed to dissipate heat quickly, reducing the time for heat to be transferred from the inside of the tissue material to the outside, avoiding the inactivation of the released target substance due to excessively high temperature of the tissue material, and ensuring the stability of grinding biological tissue materials.

[0038] As shown in the figure Figure 3This is a side view of this embodiment. In this embodiment, the rotating power unit 2 is fixed to the base 1 by a frame 7. The frame 7 includes a vertical plate 71, a support plate 72, a guide groove 73, and a slide rod 74. The vertical plate 71 is vertically fixed to the base 1. The vertical plate 71 has a guide groove 73 on the side near the mortar. The support plate 72 is horizontally positioned directly above the mortar. One end of the support plate 72 extends into the guide groove 73 and is slidably connected to it. The slide rod 74 is vertically connected to the guide groove 73. The slide rod 74 passes through the support plate 72 and is slidably connected to it. One of the slide rods 74 has a thread on its outer side and is threadedly connected to the support plate 72. The threaded slide rod 74 can be rotated by a handwheel on the vertical plate or a lifting motor, thereby moving the support plate 72 up and down. This facilitates the introduction of biological tissue material into the mortar before grinding and the removal of the ground biological tissue material after grinding.

[0039] In addition, a cylinder 8 is fixed on the base 1. A limiting groove is opened on the inner wall of the cylinder 8 in the vertical direction. A limiting block 81 is fixed on the outer side of the mortar 3. When the mortar 3 is embedded in the cylinder 8, the limiting block 81 is embedded in the limiting groove and connected with it, which makes it convenient to remove the mortar and introduce the biological tissue material to be ground and transfer the ground biological tissue material.

[0040] In the aforementioned embodiments, during the grinding process of biological tissue material by the grinding head, the compacted biological tissue material is turned over using a flexible belt. When the material contains a lot of moisture or has a smooth surface, the movement of the flexible belt may result in the inability to turn the tissue material over.

[0041] Therefore, this embodiment proposes a solution for the flexible strip, as shown in the figure. Figure 6 This is a BB cross-sectional view of this embodiment. The friction structure 51 adopts any one of the following: a frosted layer, a protrusion, and a tooth groove.

[0042] In this embodiment, the flexible strip 5 has continuous toothed grooves along its longitudinal direction (that is, the length extension direction of the flexible strip 5), and the toothed grooves are located on the side of the flexible strip 5 close to the base 1.

[0043] To avoid situations where the flexible band moves but fails to turn over the compacted tissue material or the turning effect is poor, in this embodiment, a toothed groove is provided on the side of the flexible band near the base 1. On the one hand, the pressure applied by the grinding head makes the toothed groove fit with the tissue material. On the other hand, the toothed groove amplifies the pressure applied by the flexible band 5 to the tissue material during grinding, thereby making the movement of the flexible band 5 have a better turning effect on the tissue material and further ensuring the grinding effect of the biological tissue material.

[0044] In addition, the toothed grooves of the flexible band can further increase the contact area between the grinding head and the tissue material, which is beneficial for cooling the tissue material during grinding and further avoids the loss of activity of target substances such as proteins, enzymes and DNA released by cell rupture due to the high temperature generated by friction.

[0045] As a further optimization, in this embodiment of the present disclosure, the flexible strip 5 extends a guide groove 41 from the side near the bottom surface of the mortar 3.

[0046] In this embodiment, the thickness of the flexible band 5 is greater than the depth of the tooth groove, causing the flexible band 5 to extend into the guide groove 41 (the flexible band protrudes from the grinding head). This further enhances the adhesion between the flexible band and the tissue material, ensuring that the tissue material can be turned over when the flexible band moves. At the beginning of grinding, the flexible band is compressed close to the grinding head by the pressure of the grinding head. As the tissue material is continuously ground and broken, the flexible band gradually and automatically returns to its original shape. It can automatically adjust the adhesion between the flexible band and the tissue material according to the condition of the tissue material. The tissue material can be effectively turned over throughout the grinding process, further improving the grinding effect of biological experimental materials.

[0047] As shown in the figure Figure 2 This is a top view of this embodiment. The linear displacement mechanism in the aforementioned embodiment includes a mortar cover 31 and a hemisphere 32. The mortar cover 31 is fastened to the mouth of the mortar 3 and is detachably fixed to it. The plane of the hemisphere 32 is fixedly connected to the inner side of the mortar cover 31. The hemisphere 32 is located directly above the trajectory of the limiting tube 6 as it rotates with the grinding head 4. The end of the flexible belt 5 abuts against the hemisphere 32 when it passes through it.

[0048] In this embodiment, the mortar lid 31, hemisphere 32, and limiting tube 6 are used to enable the grinding head 4 to rotate synchronously with the flexible belt during grinding. The mortar lid 31 is fixed to the mouth of the mortar 3. When the end of the flexible belt moves, it cooperates with the hemisphere 32 to move along the limiting tube. This allows the tissue material to be turned over during the entire grinding process, while avoiding the use of additional power components to drive the grinding head and thus reducing the temperature of the grinding head and protecting the target substances such as proteins, enzymes, and DNA released by cell rupture.

[0049] In addition, in this embodiment, the mortar lid 31 can seal the mouth of the mortar to prevent substances released during grinding of special biological tissue materials from splashing out.

[0050] When the grinding device in the aforementioned disclosed embodiments grinds biological tissue materials, when the flexible belt moves to one side of the limiting tube, the tissue material will move to that side. As a result, some tissue material will move into the gap between the grinding head and the side wall of the mortar. Over time, some biological tissue material will remain in the gap between the grinding head and the side wall of the mortar, making it impossible for the grinding head to grind this part of the tissue material. It is then necessary to remove the grinding head and move this part of the tissue material back to the center, thereby reducing the grinding effect of the biological experimental material.

[0051] Therefore, this embodiment proposes a solution, as shown in the figure. Figure 10 This is a front view of the grinding head in this embodiment. Figure 11 This is a top view of the grinding process in this embodiment. The limiting tube 6 is arc-shaped, and the two limiting tubes 6 are arranged in an alternating manner on the side away from the slide groove 41.

[0052] In this embodiment, an arc-shaped limiting tube 6 is used, and two limiting tubes 6 are arranged in an alternating manner. When the grinding head rotates, the two limiting tubes 6 form a spiral shape, which moves the tissue material between the grinding head and the side wall of the mortar and actively pushes the tissue material back into the space between the grinding head and the mortar. In addition, when the flexible band moves to one side of the limiting tube, the part of the flexible band close to the other limiting tube cooperates with the limiting tube 6, which can actively drag the tissue material between the grinding head and the side wall of the mortar into the space between the grinding head and the mortar, further improving the grinding effect of biological experimental materials.

[0053] As a further optimization, in this embodiment, there are multiple hemispheres 32, and the number is odd. The hemispheres 32 are evenly spaced and fixed around the inner side of the lid 31, as shown in the figure. Figure 4 This is a bottom view of the bowl lid in this embodiment. The bowl lid 31 has an arc-shaped guide groove 33 between adjacent hemispheres 32. The depth of the arc-shaped guide groove 33 gradually decreases near the end of the hemisphere 32.

[0054] In this embodiment, multiple equally spaced hemispheres 32 are arranged in an odd number. This ensures that when the flexible band rotates with the grinding head, only one end of the flexible band engages with the hemisphere 32 each time, allowing the flexible band to move in only one direction at a time. The multiple hemispheres 32 enable the flexible band to move back and forth frequently. The rotation of the grinding head allows all the tissue material to be turned over. At the same time, the end of the flexible band that moves towards the mortar lid 31 extends into the arc-shaped guide groove 33, preventing the flexible band from rubbing violently against the mortar lid 31 and causing the internal temperature of the mortar to rise, thereby further improving the grinding effect of the biological tissue material.

[0055] In the aforementioned embodiment, the flexible belt 5 is driven to move by the hemisphere 32 on the lid 31. However, since the flexible belt 5 is relatively soft, in order to avoid the hemisphere pushing the flexible belt, the part of the flexible belt located outside the limiting tube will fold, resulting in the inability to effectively push the flexible belt.

[0056] Therefore, this embodiment proposes a solution, as shown in the figure. Figure 8 This is a DD cross-sectional view of this embodiment. A sealing plate 61 is fixed at one end of the limiting tube 6 near the bowl cover 31. A guide rod 62 is passed through the sealing plate 61. The guide rod 62 is parallel to the limiting tube 6. The guide rod 62 is slidably connected to the sealing plate 61 along its length extension direction. One end of the guide rod 62 is connected to the end of the flexible belt 5, and a ball 63 is fixed at the other end. The ball 63 abuts against the hemisphere 32 when it passes through it.

[0057] In this embodiment, the sealing plate 61 is used to move the end of the flexible strip in the conduit, and the hemisphere 32 is used to push the ball 63 and the guide rod 62 to move on the sealing plate, thereby driving the flexible strip to move in the limiting tube. The sealing plate has a moving thickness that can effectively limit the direction of movement of the guide rod, so that the flexible strip moves stably.

[0058] Meanwhile, the end of the limiting tube 6 near the guide groove 41 can be set to be arc-shaped and fit the outline of the grinding head. Both ends of the guide groove 41 extend to one side of the tail of the grinding head, so that the arc-shaped end of the limiting tube 6 extends into the guide groove 41, making the limiting tube 6 flush with one side of the head of the grinding head. This further prevents the part of the flexible band between the limiting tube or the guide groove from folding during movement, and further improves the grinding effect of biological tissue materials.

[0059] As mentioned above, the limiting tubes 6 are arranged in an alternating pattern, which also causes the two guide rods 62 to be arranged in an alternating pattern. When the guide rods 62 rotate with the grinding head, the air in the annular area between the tail of the grinding head and the mortar is agitated by the two alternating guide rods 62. The exhaust holes and ventilation holes provided on the mortar lid enable the air inside the mortar to flow quickly, thereby enhancing the heat dissipation effect of the material during grinding.

[0060] As a further optimization, in this embodiment of the present disclosure, a first spring 64 is sleeved on the guide rod 62, one end of the first spring 64 is connected to the end of the flexible belt 5, and the other end is connected to the sealing plate 61.

[0061] In this embodiment, after the hemisphere pushes the flexible belt to one side using the first spring 64, the flexible belt quickly returns to its original shape before the next movement. The spring also enables the flexible belt to effectively flip the materials while returning to its original shape.

[0062] The biological experimental material grinding device of the present invention, when grinding biological tissue materials, causes the grinding head to be unable to compact the tissue material as the tissue continuously breaks down and the cells continuously rupture, resulting in a slowdown in the cell rupture rate.

[0063] Therefore, this embodiment proposes a solution: a connecting shaft 42 is provided on the bowl cover 31 and slidably connected thereto. The connecting shaft 42 is coaxial with the grinding head 4. One end of the connecting shaft 42 is connected to the grinding head 4, and the other end is connected to the output shaft of the rotating power unit 2. A second spring 43 is sleeved on the connecting shaft 42. One end of the second spring 43 abuts against the bowl cover 31, and the other end abuts against the grinding head 4.

[0064] In this embodiment, the rotating power unit 2 drives the grinding head 4 to rotate via the connecting shaft 42, while the second spring 43 is sleeved on the connecting shaft 42. The second spring 43 is used to keep the grinding head 4 pressing the tissue material, ensuring the tissue cell rupture speed.

[0065] The rotating power unit 2 in this embodiment consists of a motor 21, a pulley 22, a belt 23, and a protective cover 24. The motor 21 is fixed on the frame 7 and located above the base 1. The connecting shaft 42 is rotatably connected to the frame 7 through a bearing. The pulley 22 is sleeved on the output shaft of the motor 21 and the belt 23 is used to transmit power to the two pulleys 22.

[0066] As a further optimization, in this embodiment of the disclosure, as shown in the figure, Figure 9 The enlarged schematic diagram at point E in this embodiment shows that an external threaded sleeve 44 is provided on the bowl cover 31. The external threaded sleeve 44 is threadedly connected to the bowl cover 31. The connecting shaft 42 passes through the external threaded sleeve 44 and is slidably connected to it. The end of the second spring 43 away from the grinding head 4 abuts against the external threaded sleeve 44. A handwheel is sleeved on the end of the external threaded sleeve 44 located outside the bowl cover 31.

[0067] In this embodiment, the external threaded sleeve 44 is threadedly connected to the bowl cover 31, and the external threaded sleeve 44 abuts against the second spring 43. This allows the experimenter to manually turn the external threaded sleeve 44 using a handwheel to adjust its axial position, thereby adjusting the distance between the end of the external threaded sleeve 44 near the grinding head and the grinding head. This also allows for adjustment of the pressure applied by the second spring to the grinding head, enabling the grinding of biological tissue materials of different hardness.

[0068] In this embodiment, since the second spring abuts against the external threaded sleeve, it is necessary to avoid the second spring from obstructing the turning of the external threaded sleeve.

[0069] Therefore, an annular connecting plate 45 is coaxially provided at one end of the external threaded sleeve 44 near the grinding head 4, and an annular groove is provided at the end of the external threaded sleeve 44. One end of the annular connecting plate 45 is rotatably connected to the annular groove through a bearing, and the end of the second spring 43 away from the grinding head 4 is connected to the annular connecting plate 45.

[0070] The above-disclosed embodiments are merely preferred embodiments of the present invention. However, the embodiments of the present invention are not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A grinding device for experimental materials used in biological experiments, characterized in that, The utility model provides a kind of biological tissue grinder, including: Base (1) and rotating power part (2) arranged on the base (1); Mill (3), fixed on the base (1); Grinding head (4) is coaxially arranged in the mill (3), the grinding head (4) is connected with the rotating output shaft of rotating power part (2);The head of the grinding head (4) is provided with guide slot (41) along its radial profile direction; Flexible belt (5) is arranged in the guide slot (41), and the flexible belt (5) is provided with friction structure (51) along its longitudinal direction; Driving assembly, including: two limit tubes (6) and linear displacement mechanism, two the limit tube (6) is fixed on grinding head (4), and is located grinding head (4) near the two sides of the end of guide slot (41), flexible belt (5) extends sliding slot (41) and extends to corresponding the limit tube (6) in, the linear displacement mechanism is arranged on limit tube (6), and the displacement output end of linear displacement mechanism is connected with the two ends of flexible belt (5), for driving flexible belt (5) reciprocating movement along guide slot (41) in grinding, so that friction structure (51) is contacted with biological tissue material and is applied to the friction force along the radial direction of grinding head (4) to realize the tumbling of biological tissue material.

2. The biological experimental sample grinding apparatus according to claim 1, wherein The friction structure (51) adopts any one of frosted layer, protrusion and tooth groove.

3. The biological experimental experimental material grinding apparatus according to claim 1, wherein The flexible belt (5) extends out of the guide slot (41) on the side close to the bottom surface of the mill (3).

4. The biological experimental material grinding apparatus according to claim 1, wherein The linear displacement mechanism includes: a bowl cover (31), a hemisphere (32), the bowl cover (31) is buckled on the mouth of the mill (3) and is detachably fixedly connected therewith, the plane of the hemisphere (32) is fixedly connected with the inner side of the bowl cover (31), the hemisphere (32) is located directly above the limit tube (6) along with the rotating movement track of the grinding head (4), and the end of the flexible belt (5) abuts against the hemisphere (32) when passing through the hemisphere (32).

5. The biological experimental sample grinding apparatus according to claim 4, wherein The limit tube (6) is arc-shaped, and the sides of the two limit tubes (6) away from the sliding slot (41) are arranged in a staggered manner.

6. The biological experimental material grinding apparatus according to claim 4, wherein There are multiple hemispheres (32), and the number of hemispheres (32) is odd, the hemispheres (32) are fixedly arranged on the inner side of the bowl cover (31) at equal intervals, the bowl cover (31) is provided with an arc-shaped guide slot (33) between adjacent hemispheres (32), and the depth of the arc-shaped guide slot (33) gradually decreases near one end of the hemisphere (32).

7. The biological experimental sample grinding apparatus according to claim 4, wherein One end of the limit tube (6) close to the bowl cover (31) is fixedly provided with a sealing plate (61), a guide rod (62) is arranged on the sealing plate (61), the guide rod (62) is parallel to the limit tube (6), the guide rod (62) is slidably connected with the sealing plate (61) along the length extension direction thereof, one end of the guide rod (62) is connected with the end of the flexible belt (5), the other end of the guide rod (62) is fixedly provided with a ball (63), and the ball (63) abuts against the hemisphere (32) when passing through the hemisphere (32).

8. The biological experimental material grinding apparatus according to claim 7, wherein A first spring (64) is sleeved on the guide rod (62), one end of the first spring (64) is connected with the end of the flexible belt (5), and the other end of the first spring (64) is connected with the sealing plate (61).

9. The biological experimental experimental material grinding apparatus according to claim 4, wherein A connecting shaft (42) is arranged through the bowl cover (31) and is in sliding connection with the bowl cover (31), the connecting shaft (42) is coaxial with the grinding head (4), one end of the connecting shaft (42) is connected with the grinding head (4), the other end is connected with the output shaft of the rotary power part (2), a second spring (43) is sleeved on the connecting shaft (42), one end of the second spring (43) is in abutment with the bowl cover (31), the other end is in abutment with the grinding head (4).

10. The biological experimental material grinding apparatus according to claim 9, wherein An outer threaded sleeve (44) is arranged through the bowl cover (31), the outer threaded sleeve (44) is in threaded connection with the bowl cover (31), the connecting shaft (42) passes through the outer threaded sleeve (44) and is in sliding connection with the outer threaded sleeve (44), one end of the second spring (43) away from the grinding head (4) is in abutment with the outer threaded sleeve (44), and a hand wheel is sleeved on one end of the outer threaded sleeve (44) located outside the bowl cover (31).

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