An implantable detection chip and control method for atopic dermatitis inducers

Abstract

The present invention discloses an implantable detection chip for atopic dermatitis inducers and a control method thereof, relating to the technical field of atopic dermatitis inducer detection, including a subcutaneous implantable allergen detection chip 1 and a chip packaging structure. The subcutaneous implantable allergen detection chip 1 includes a substrate, an MCU core, a biosensor unit, a controllable puncture detection unit, a wireless radio frequency module, and a power supply unit. The present invention can add a design of a controllable puncture detection unit to a traditional implantable chip. The controllable puncture detection unit is wrapped inside the chip packaging structure before being implanted subcutaneously. After the implantation is completed, the controllable puncture detection unit punctures the chip packaging structure under the control of the MCU core and contacts the subcutaneous tissue, allowing the biosensor unit to directly perform biological detection, thereby enabling the collection of serum-specific sIgE data. The data is then exchanged with an external detection terminal through the wireless radio frequency module, thereby enabling uninterrupted biological detection.

Description

Technical Field

[0001] The present invention relates to the technical field of atopic dermatitis inducement detection, in particular to an atopic dermatitis inducement implantable detection chip and a control method. Background Art

[0002] Atopic dermatitis, also known as contact dermatitis, is an inflammation of the skin caused by contact with a specific substance. There are two main types of atopic dermatitis: irritant contact dermatitis and allergic contact dermatitis.

[0003] Irritant contact dermatitis is caused by substances that directly irritate the skin, such as acids, alkalis, solvents, detergents, and industrial chemicals. Symptoms can occur in anyone exposed to a sufficient dose, independent of the immune system. Symptoms include erythema, itching, burning, and dry skin.

[0004] Allergic contact dermatitis is caused by an immune system response to certain substances, called allergens. Common allergens include nickel, fragrances, rubber additives, dyes, preservatives, and plants (such as poison ivy and poison oak). Symptoms typically appear within 24-48 hours of contact and include itching, erythema, blisters, dry skin, and scaling.

[0005] In addition to these chemical and physical factors, triggers of atopic dermatitis may include:

[0006] Occupation: People in certain occupations are frequently exposed to potential triggers due to the nature of their work, such as medical staff, metal workers, hairdressers, etc.

[0007] Personal care products: Cosmetics, perfumes, skin care products, soaps, shampoos, etc. may contain irritating or allergenic ingredients.

[0008] Metal: Especially jewelry and watch straps containing nickel, are common allergens.

[0009] Plants: Such as poison ivy, poison oak, and poison sumac, which contain oils that can cause allergic reactions.

[0010] Diagnosis of atopic dermatitis typically relies on medical history, skin testing (such as patch testing), and avoidance of suspected allergens. Treatment includes avoidance of known triggers, moisturizers, topical corticosteroids, and immunomodulators. In some cases, consultation with a dermatologist or allergist may be necessary.

[0011] However, this method of judging the cause of atopic dermatitis based on subjective experience of medical history is not very accurate and can easily lead to misdiagnosis. Therefore, there is an urgent need to design a device that can be used for the detection of atopic dermatitis causes to accurately analyze the causes of atopic dermatitis. Summary of the Invention

[0012] In order to solve the above technical problems, the present invention provides an implantable detection chip and control method for atopic dermatitis inducers. The following technical solutions are adopted:

[0013] An implantable detection chip for the cause of specific dermatitis, comprising a subcutaneous implantable allergen detection chip 1 and a chip packaging structure. The subcutaneous implantable allergen detection chip 1 comprises a substrate, an MCU core, a biosensor unit, a controllable puncture detection unit, a wireless radio frequency module, and a power supply unit;

[0014] The MCU core, biosensor unit, controllable puncture detection unit, wireless radio frequency module and power supply unit are respectively integrated on the substrate; the digital signal output end of the controllable puncture detection unit is communicatively connected to the signal input end of the biosensor unit; the biosensor unit and the wireless radio frequency module are respectively communicatively connected to the MCU core; the controllable puncture detection unit is provided with a puncture needle; the MCU core controls the execution action of the controllable puncture detection unit, and the execution action includes controlling the extension of the puncture needle; the power supply unit supplies power to the MCU core, biosensor unit, controllable puncture detection unit and wireless radio frequency module respectively; the wireless radio frequency module is wirelessly connected to an external detection terminal; the external detection terminal is a computer with a wireless radio frequency receiving module; the chip packaging structure is wrapped around the periphery of the subcutaneously implantable allergen detection chip 1.

[0015] By adopting the above technical solution, since the causes of atopic dermatitis are very complex, if the cause is determined simply by interviewing, an implantable detection chip can be used to perform real-time biological detection of serum-specific sIge in subcutaneous tissue. Doctors can analyze the patient's biological detection data at regular intervals, combined with interviews, to more accurately determine the cause of atopic dermatitis.

[0016] The specific implantable detection chip adds a controllable puncture detection unit design on the basis of the traditional implantable chip. The controllable puncture detection unit is wrapped inside the chip packaging structure before being implanted subcutaneously. The chip packaging structure can be made of biomedical polymer materials to minimize the impact on the human body. After the implantation is completed, the controllable puncture detection unit can puncture the chip packaging structure and contact the subcutaneous tissue under the control of the MCU core, so that the biosensor unit can directly perform biological detection. The recognition element of the biosensor unit is made of biosensitive materials and can perform sensing and detection of bioactive substances such as enzymes, antibodies, antigens, microorganisms, cells, tissues, nucleic acids, etc., and can realize the collection of serum-specific sIge data, and then exchange data with the external detection terminal through the wireless radio frequency module to achieve uninterrupted biological detection.

[0017] Optionally, a storage unit is also included, which is communicatively connected to the MCU core and is used to store detection result data.

[0018] By adopting the above technical solution, the storage unit serves as a cache or backup of detection data, so as to back up the data in case the wireless radio frequency module fails due to implantation, and the data can be read after removing the implanted detection chip.

[0019] Optionally, a clock module is further included. The clock module 18 is communicatively connected to the MCU core. The MCU core combines the time data generated by the MCU core with the detection data of the biosensor unit to generate a biological detection data packet.

[0020] By adopting the above technical solution, the detection data with time data allows doctors to make more accurate inquiries. For example, the serum-specific sIge data at the corresponding time can be used to ask patients whether they have been in contact with or eaten a certain allergen at a certain time, thereby accurately determining the cause of atopic dermatitis.

[0021] Optionally, the controllable puncture detection unit includes a puncture base, a piston rod, a puncture needle and a micro-electrically controlled valve. The puncture base is provided with a compressed air chamber and a piston chamber. The bottom of the puncture base is fixedly mounted on the surface of the substrate. The piston rod is located in the piston chamber and moves up and down. The piston chamber is connected to the compressed air chamber through the micro-electrically controlled valve. The MCU core controls the execution action of the micro-electrically controlled valve. When the MCU core controls the micro-electrically controlled valve to open, the compressed air in the compressed air chamber enters the piston chamber to push the piston rod outward. The bottom end of the puncture needle is fixedly connected to the outer surface of the piston rod. When the piston rod is pushed outward, the top tip of the puncture needle punctures the chip packaging structure. The biosensor unit adopts a split structure. The biological recognition element of the biosensor unit is mounted on the outer wall of the puncture needle. When the puncture needle punctures the chip packaging structure and contacts the subcutaneous tissue, the biological recognition element contacts the subcutaneous tissue to detect bioactive substances. The biological recognition element and the core of the biosensor unit are connected through jumper communication.

[0022] Optionally, the controllable puncture detection unit further includes a one-way valve and an inflation port, and the inflation port is connected to the compressed air cavity through the one-way valve.

[0023] By adopting the above technical solution, the puncture needle of the controllable puncture detection unit cannot protrude before implantation. Firstly, it will affect the implantation process and cannot guarantee the hygiene level. The automatic control design of the puncture is based on the controlled release of compressed air. The motor drive is not used because the battery power supply is not suitable for driving and the motor is too large. The air in the compressed air cavity is filled with compressed gas through the inflation port through the one-way valve before packaging. After the implantation is completed, the MCU core can drive the puncture needle outward to pierce the chip packaging structure by opening the micro-electrically controlled valve, so that the biometric recognition element is in direct contact with the subcutaneous tissue. The amount of penetration of the puncture needle into the subcutaneous tissue needs to not exceed 0.2mm to minimize the impact on human tissue.

[0024] Optionally, the number of the controllable puncture detection units is at least two, and the two controllable puncture detection units are respectively installed on two side surfaces of the substrate.

[0025] By adopting the above technical solution, the controllable puncture detection unit generally adopts two designs to perform puncture biological detection on the two sides of the substrate.

[0026] Optionally, the chip packaging structure is a medical silicone wrapping package with a thickness of 0.2mm-0.3mm and a capsule shape. The outside of the chip packaging structure is provided with an anti-slip coating. When the medical silicone wrapping package is completed, the top tip of the puncture needle on the piston rod in place rests against the inner wall of the chip packaging structure. When the piston rod is pushed out, the top tip of the puncture needle pierces the chip packaging structure, allowing the biometric identification element to directly contact the subcutaneous tissue.

[0027] By adopting the above technical solution, the medical silicone encapsulation is a packaging material made of biomedical polymer materials, which is encapsulated in a fully encapsulated form to avoid irritation to the subcutaneous tissue of the implantation site. The anti-slip coating adopts a biological coating to fix the position of the implantable detection chip.

[0028] Optionally, there are at least two wireless radio frequency modules, which are fixed on two sides of the substrate respectively and are communicatively connected to the MCU core via jumpers.

[0029] By adopting the above technical solution, the two wireless radio frequency modules can realize wireless data transmission more reliably.

[0030] Optionally, the power supply unit includes a micro button battery and a power management chip, wherein the power management chip is communicatively connected to the MCU core and controls the micro button battery to supply power to each electrical component respectively.

[0031] By adopting the above technical solution, the micro button battery can power various electrical devices and can maintain a detection cycle, such as a day.

[0032] A control method for an implantable detection chip for atopic dermatitis inducement uses an implantable detection chip for atopic dermatitis inducement to perform biological detection on subcutaneous tissue, comprising the following steps:

[0033] Step 1: After an implantable detection chip for atopic dermatitis is implanted, the external detection terminal sends an activation instruction to the wireless radio frequency module, and the wireless radio frequency module forwards the activation instruction to the MCU core;

[0034] Step 2: The MCU core controls the self-test of each component and starts the controllable puncture detection unit;

[0035] Step 3: The MCU core controls the micro-electrically controlled valve to open. The compressed air in the compressed air chamber enters the piston chamber. The piston rod drives the puncture needle outward to pierce the chip package structure. The biometric recognition element contacts the subcutaneous tissue to perform biological detection and transmits the detection analog data to the core of the biosensor unit. The biosensor unit transmits the processed biological detection data to the MCU core.

[0036] In step 4, the MCU core transmits the detected biological detection data to the storage unit, and exchanges the biological detection data with the external detection terminal through the wireless radio frequency module.

[0037] Optionally, in step 4, when receiving data transmitted by the biosensor unit, the MCU core synchronously collects time data from the clock module, and packages the time data with the biodetection data and sends them to the external detection terminal.

[0038] In summary, the present invention includes at least one of the following beneficial technical effects:

[0039] The present invention can provide an implantable detection chip for causes of specific dermatitis and a control method. A controllable puncture detection unit is added to a traditional implantable chip. Before being implanted subcutaneously, the controllable puncture detection unit is wrapped inside a chip packaging structure made of biomedical polymer materials to minimize the impact on the human body. After the implantation is completed, the controllable puncture detection unit punctures the chip packaging structure under the control of an MCU core and contacts the subcutaneous tissue, allowing the biosensor unit to directly perform biological detection. The identification element of the biosensor unit is made of biosensitive materials and can perform sensing detection of bioactive substances such as enzymes, antibodies, antigens, microorganisms, cells, tissues, nucleic acids, etc., can realize the collection of serum-specific sIge data, and then exchange data with an external detection terminal through a wireless radio frequency module to achieve uninterrupted biological detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 This is a schematic diagram of the electrical component connection principle of an implantable detection chip for atopic dermatitis inducement of the present invention;

[0041] Figure 2 This is a schematic diagram of the structural principle of the subcutaneous implantable allergen detection chip packaged in the present invention;

[0042] Figure 3 This is a schematic diagram of the structural principle of the subcutaneous implantable allergen detection chip of the present invention, wherein the puncture needle punctures the chip packaging structure;

[0043] Figure 4 The diagram is a schematic diagram of the structural principle of a controllable puncture detection unit of an implantable detection chip for atopic dermatitis inducement according to the present invention.

[0044] Explanation of the accompanying symbols: 1. Subcutaneously implantable allergen detection chip; 11. Substrate; 12. MCU core; 13. Biosensor unit; 131. Biometric identification element; 14. Controllable puncture detection unit; 141. Puncture base; 1411. Compressed air chamber; 1412. Piston chamber; 142. Piston rod; 143. Puncture needle; 144. Micro-electrically controlled valve; 145. One-way valve; 146. Inflation port; 15. Wireless RF module 16. Power supply unit; 161. Micro button battery; 162. Power management chip; 17. Storage unit; 18. Clock module; 2. Chip packaging structure; 100. External detection terminal. DETAILED DESCRIPTION

[0045] The present invention will be further described in detail below with reference to the accompanying drawings.

[0046] The embodiment of the present invention discloses an implantable detection chip for causes of atopic dermatitis and a control method.

[0047] Reference Figure 1-Figure 4 , an implantable detection chip for atopic dermatitis inducements, comprising a subcutaneous implantable allergen detection chip 1 and a chip packaging structure 2, wherein the subcutaneous implantable allergen detection chip 1 comprises a substrate 11, an MCU core 12, a biosensor unit 13, a controllable puncture detection unit 14, a wireless radio frequency module 15, and a power supply unit 16;

[0048] The MCU core 12, the biosensor unit 13, the controllable puncture detection unit 14, the wireless radio frequency module 15 and the power supply unit 16 are respectively integrated on the substrate 11. The digital signal output end of the controllable puncture detection unit 14 is communicatively connected to the signal input end of the biosensor unit 13. The biosensor unit 13 and the wireless radio frequency module 15 are respectively communicatively connected to the MCU core 12. The controllable puncture detection unit 14 is provided with a puncture needle 143. The MCU core 12 controls the execution action of the controllable puncture detection unit 14, and the execution action includes controlling the extension of the puncture needle 143. The power supply unit 16 supplies power to the MCU core 12, the biosensor unit 13, the controllable puncture detection unit 14 and the wireless radio frequency module 15 respectively. The wireless radio frequency module 15 is wirelessly connected to the external detection terminal 100. The external detection terminal 100 is a computer with a wireless radio frequency receiving module. The chip packaging structure 2 is wrapped around the periphery of the subcutaneously implantable allergen detection chip 1.

[0049] Since the causes of atopic dermatitis are very complex, if the cause is determined solely through interviews, an implantable detection chip can be used to perform real-time biological testing of serum-specific sIge in subcutaneous tissue. Doctors can analyze the patient's biological test data at regular intervals, combined with interviews, to more accurately determine the cause of atopic dermatitis.

[0050] The specific implantable detection chip adds a controllable puncture detection unit 14 to the traditional implantable chip. The controllable puncture detection unit 14 is wrapped inside the chip packaging structure 2 before being implanted subcutaneously. The chip packaging structure 2 can be made of biomedical polymer materials to minimize the impact on the human body. After the implantation is completed, the controllable puncture detection unit 14 can puncture the chip packaging structure 2 and contact the subcutaneous tissue under the control of the MCU core 12, so that the biosensor unit 13 can directly perform biological detection. The recognition element of the biosensor unit 13 is made of biological sensitive materials and can perform sensing detection of bioactive substances such as enzymes, antibodies, antigens, microorganisms, cells, tissues, nucleic acids, etc., and can realize the collection of serum-specific sIge data, and then exchange data with the external detection terminal 100 through the wireless radio frequency module 15 to achieve uninterrupted biological detection.

[0051] The system further includes a storage unit 17 , which is in communication with the MCU core 12 and is used to store detection result data.

[0052] The storage unit 17 is used to cache or back up the detection data in case the wireless radio frequency module 15 fails due to implantation, and can be read after the implanted detection chip is removed.

[0053] The system further includes a clock module 18 , which is in communication with the MCU core 12 . The MCU core 12 combines the time data generated by the MCU core 12 with the detection data of the biosensor unit 13 to generate a biological detection data packet.

[0054] The test data with time data allows doctors to make more accurate inquiries. For example, they can use the serum-specific sIge data at the corresponding time to ask patients whether they have been exposed to or eaten a certain allergen at a certain time, thereby accurately determining the cause of atopic dermatitis.

[0055] The controllable puncture detection unit 14 includes a puncture base 141, a piston rod 142, a puncture needle 143, and a micro-electrically controlled valve 144. The puncture base 141 is provided with a compressed air chamber 1411 and a piston chamber 1412. The bottom of the puncture base 141 is fixedly mounted on the surface of the substrate 11. The piston rod 142 is located in the piston chamber 1412 and moves up and down. The piston chamber 1412 is connected to the compressed air chamber 1411 through the micro-electrically controlled valve 144. The MCU core 12 controls the execution of the micro-electrically controlled valve 144. When the MCU core 12 controls the micro-electrically controlled valve 144 to open, the compressed air in the compressed air chamber 1411 is released. Enter the piston cavity 1412 and push the piston rod 142 outward. The bottom end of the puncture needle 143 is fixedly connected to the outer surface of the piston rod 142. When the piston rod 142 is pushed outward, the top tip of the puncture needle 143 pierces the chip packaging structure 2. The biosensor unit 13 adopts a split structure. The biometric identification element 131 of the biosensor unit 13 is mounted on the outer wall of the puncture needle 143. When the puncture needle 143 pierces the chip packaging structure 2 and contacts the subcutaneous tissue, the biometric identification element 131 contacts the subcutaneous tissue to detect bioactive substances. The biometric identification element 131 is connected to the core of the biosensor unit 13 through a jumper communication connection.

[0056] The controllable puncture detection unit 14 further includes a one-way valve 145 and an air filling port 146 . The air filling port 146 is connected to the compressed air chamber 1411 through the one-way valve 145 .

[0057] The puncture needle 143 of the controllable puncture detection unit 14 cannot protrude outward before implantation. Firstly, it will affect the implantation process and cannot ensure the hygiene level. The automatic control design of the puncture is based on the controlled release of compressed air. It does not use a motor drive because battery power is not suitable for driving and secondly, the motor is too large. The air in the compressed air cavity 1411 is filled with compressed gas through the one-way valve 145 using the inflation port 146 before packaging. After the implantation is completed, the MCU core 12 can drive the puncture needle 143 to puncture the chip packaging structure 2 outward by opening the micro-electrically controlled valve 144, so that the biometric recognition element 131 is in direct contact with the subcutaneous tissue. The amount of outward penetration of the puncture needle 143 into the subcutaneous tissue needs to not exceed 0.2mm to minimize the impact on human tissue.

[0058] The number of the controllable puncture detection units 14 is at least two, and the two controllable puncture detection units 14 are respectively installed on two side surfaces of the substrate 11 .

[0059] The controllable puncture detection unit 14 generally adopts two designs, performing puncture biological detection on the two sides of the substrate 11.

[0060] The chip packaging structure 2 is a medical silicone wrapped package with a thickness of 0.2mm-0.3mm and a capsule shape. The outside of the chip packaging structure 2 is provided with an anti-slip coating. When the medical silicone wrapping package is completed, the top tip of the puncture needle 143 on the piston rod 142 in place is against the inner wall of the chip packaging structure 2. When the piston rod 142 is pushed out, the top tip of the puncture needle 143 pierces the chip packaging structure 2, allowing the biometric identification element 131 to directly contact the subcutaneous tissue.

[0061] Medical silicone encapsulation is a packaging material made of biomedical polymer materials. It is fully encapsulated to avoid irritation to the subcutaneous tissue at the implantation site. The anti-slip coating uses a biological coating to fix the position of the implanted detection chip.

[0062] There are at least two wireless radio frequency modules 15 , which are fixed on two sides of the substrate 11 respectively and are communicatively connected to the MCU core 12 via jumpers.

[0063] The two wireless radio frequency modules 15 can realize wireless data transmission more reliably.

[0064] The power supply unit 16 includes a micro button battery 161 and a power management chip 162 . The power management chip 162 is in communication with the MCU core 12 and controls the micro button battery 161 to supply power to each electrical component.

[0065] The micro button battery 161 can provide power for various electrical components and can maintain a detection cycle, for example, 15 days.

[0066] A control method for an implantable detection chip for atopic dermatitis inducement uses an implantable detection chip for atopic dermatitis inducement to perform biological detection on subcutaneous tissue, comprising the following steps:

[0067] Step 1: After an implantable detection chip for atopic dermatitis is implanted, the external detection terminal 100 sends an activation instruction to the wireless radio frequency module 15, and the wireless radio frequency module 15 forwards the activation instruction to the MCU core 12;

[0068] Step 2: The MCU core 12 controls each component to self-check and controls the controllable puncture detection unit 14 to start;

[0069] Step 3: The MCU core 12 controls the micro-electrically controlled valve 144 to open. The compressed air in the compressed air chamber 1411 enters the piston chamber 1412. The piston rod 142 drives the puncture needle 143 to pierce the chip package structure 2. The biometric recognition element 131 contacts the subcutaneous tissue to perform biological detection and transmits the detection analog data to the core of the biosensor unit 13. The biosensor unit 13 transmits the processed biological detection data to the MCU core 12.

[0070] In step 4, the MCU core 12 transmits the detected biological detection data to the storage unit 17 , and exchanges the biological detection data with the external detection terminal 100 through the wireless radio frequency module 15 .

[0071] In step 4 , when receiving data transmitted by the biosensor unit 13 , the MCU core 12 synchronously collects time data from the clock module 18 , packages the time data with the biodetection data, and sends the data to the external detection terminal 100 .

[0072] The following uses a specific case to illustrate the implementation principle of an implantable detection chip and control method for atopic dermatitis inducers:

[0073] A child with atopic dermatitis was diagnosed after excluding a history of parasitic infection, severe heart, liver, and kidney dysfunction, congenital malformations, gastrointestinal infections, and respiratory infections. To identify the cause of atopic dermatitis, an implantable detection chip was used for auxiliary testing. The chip was subcutaneously implanted at the site of the atopic dermatitis symptoms, eliminating the need for daily peripheral blood collection and allowing for the reading of specific data at set time periods. The dietary allergen group included 10 types: shellfish, egg white, milk, crab, shrimp, beef, lamb, mango, peanuts, and soybeans. The ingested allergens included 8 types: mold combination, cat hair, cockroaches, mites, plastic, rubber, gasoline, and pollen.

[0074] During the first 24 hours of the test cycle, allergen serum sIgE positive rate tests were performed every 8 hours. The test results are shown in Table 1. Table 1 shows the allergen serum sIgE and total serum IgE values:

[0075] Table 1

[0076]

[0077]

[0078] The doctor quickly found that the IGE value of plastic allergens was abnormal after the first test day, which was most likely the cause of atopic dermatitis. After interviewing the child's parents, they learned that due to their busy work recently, they often cooked the day's dishes in the morning and packed them in plastic boxes, and then heated them in the microwave or other heating methods. The child had been eating in this way very frequently for a period of time. Therefore, the doctor judged that the reaction between plastic materials and hot food caused the allergen plastic to be accidentally ingested, thereby inducing atopic dermatitis. This is a relatively typical cause. Because the facts are clear and the IGE value of the plastic allergen is single and prominent, the cause of atopic dermatitis can be directly determined.

[0079] The above are all preferred embodiments of the present invention, and are not intended to limit the scope of protection of the present invention. Therefore, any equivalent changes made based on the structure, shape, and principle of the present invention should be included in the scope of protection of the present invention.

Claims

1. An implantable chip for detecting the cause of atopic dermatitis, characterized by: It comprises a subcutaneously implantable allergen detection chip (1) and a chip packaging structure (2), wherein the subcutaneously implantable allergen detection chip (1) comprises a substrate (11), an MCU core (12), a biosensor unit (13), a controllable puncture detection unit (14), a wireless radio frequency module (15) and a power supply unit (16); The MCU core (12), the biosensor unit (13), the controllable puncture detection unit (14), the wireless radio frequency module (15) and the power supply unit (16) are respectively integrated on the substrate (11); the digital signal output end of the controllable puncture detection unit (14) is communicatively connected to the signal input end of the biosensor unit (13); the biosensor unit (13) and the wireless radio frequency module (15) are respectively communicatively connected to the MCU core (12); the controllable puncture detection unit (14) is provided with a puncture needle (143); the MCU core (12) controls The controllable puncture detection unit (14) controls the execution action, and the execution action includes controlling the extension of the puncture needle (143). The power supply unit (16) supplies power to the MCU core (12), the biosensor unit (13), the controllable puncture detection unit (14) and the wireless radio frequency module (15). The wireless radio frequency module (15) is wirelessly connected to the external detection terminal (100). The external detection terminal (100) is a computer with a wireless radio frequency receiving module. The chip packaging structure (2) is wrapped around the periphery of the subcutaneously implantable allergen detection chip (1); The controllable puncture detection unit (14) includes a puncture base (141), a piston rod (142), a puncture needle (143) and a micro-electrically controlled valve (144). The puncture base (141) is provided with a compressed air chamber (1411) and a piston chamber (1412). The bottom of the puncture base (141) is fixedly mounted on the surface of the substrate (11). The piston rod (142) is located in the piston chamber (1412) and moves up and down. The piston chamber (1412) is connected to the compressed air chamber (1411) through the micro-electrically controlled valve (144). The MCU core (12) controls the execution of the micro-electrically controlled valve (144). When the MCU core (12) controls the micro-electrically controlled valve (144) to open, the compressed air chamber (1411) is opened. The compressed air enters the piston chamber (1412) to push the piston rod (142) outward, and the bottom end of the puncture needle (143) is fixedly connected to the outer surface of the piston rod (142). When the piston rod (142) is pushed outward, the top tip of the puncture needle (143) punctures the chip packaging structure (2). The biosensor unit (13) adopts a split structure. The biorecognition element (131) of the biosensor unit (13) is mounted on the outer wall of the puncture needle (143). When the puncture needle (143) punctures the chip packaging structure (2) and contacts the subcutaneous tissue, the biorecognition element (131) contacts the subcutaneous tissue to detect bioactive substances. The biorecognition element (131) and the core of the biosensor unit (13) are connected to each other through a jumper.

2. The implantable detection chip for atopic dermatitis inducement according to claim 1, characterized in that: It also includes a storage unit (17), which is communicatively connected to the MCU core (12) and is used to store detection result data.

3. The implantable detection chip for atopic dermatitis inducement according to claim 2, characterized in that: The system further includes a clock module (18), wherein the clock module (18) is in communication with the MCU core (12), and the MCU core (12) combines the time data generated by the MCU core (12) with the detection data of the biosensor unit (13) to generate a biodetection data packet.

4. The implantable detection chip for atopic dermatitis inducement according to claim 3, characterized in that: The controllable puncture detection unit (14) further includes a one-way valve (145) and an air filling port (146), wherein the air filling port (146) is connected to the compressed air cavity (1411) via the one-way valve (145).

5. The implantable detection chip for atopic dermatitis inducement according to claim 4, characterized in that: The number of the controllable puncture detection units (14) is at least two, and the two controllable puncture detection units (14) are respectively mounted on two side surfaces of the base plate (11).

6. The implantable detection chip for atopic dermatitis inducement according to claim 5, characterized in that: The chip packaging structure (2) is a medical silicone encapsulation package with a thickness of 0.2 mm to 0.3 mm and a capsule-shaped appearance. An anti-slip coating is provided on the outer side of the chip packaging structure (2). When the medical silicone encapsulation is completed, the top tip of the puncture needle (143) on the piston rod (142) in the original position abuts against the inner wall of the chip packaging structure (2). When the piston rod (142) is pushed out, the top tip of the puncture needle (143) pierces the chip packaging structure (2), so that the biometric identification element (131) is in direct contact with the subcutaneous tissue.

7. The implantable detection chip for atopic dermatitis inducement according to claim 6, characterized in that: The power supply unit (16) includes a micro button battery (161) and a power management chip (162). The power management chip (162) is connected to the MCU core (12) for communication and controls the micro button battery (161) to supply power to each electrical device.

8. A control method for an implantable detection chip for atopic dermatitis inducement, characterized by: Using the implantable detection chip for specific dermatitis inducement according to claim 7 to perform biological detection on subcutaneous tissue comprises the following steps: Step 1: After an implantable detection chip for atopic dermatitis is implanted, the external detection terminal (100) sends an activation instruction to the wireless radio frequency module (15), and the wireless radio frequency module (15) forwards the activation instruction to the MCU core (12); Step 2, the MCU core (12) controls the self-test of each component and controls the start-up of the controllable puncture detection unit (14); Step 3, the MCU core (12) controls the micro-electrically controlled valve (144) to open, the compressed air in the compressed air chamber (1411) enters the piston chamber (1412), the piston rod (142) drives the puncture needle (143) to puncture the chip packaging structure (2) outward, the biometric element (131) contacts the subcutaneous tissue to perform biological detection, and transmits the detection simulation data to the core of the biosensor unit (13), and the biosensor unit (13) transmits the processed biological detection data to the MCU core (12); In step 4, the MCU core (12) transmits the detected biological detection data to the storage unit (17), and exchanges the biological detection data with the external detection terminal (100) through the wireless radio frequency module (15).

9. The control method of an implantable detection chip for atopic dermatitis inducement according to claim 8, characterized in that: In step 4, when receiving data transmitted by the biosensor unit (13), the MCU core (12) synchronously collects time data from the clock module (18), packages the time data with the biodetection data, and sends the data to the external detection terminal (100).

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