A dietary fiber that can be used for weight management and has high expansion in gastric juice, and its preparation and application

Abstract

The present invention discloses a dietary fiber that can be used for weight management and has high expansion in gastric juice, and its preparation and application. The dietary fiber is composed of a three-dimensional network structure and a support structure interlaced. The three-dimensional network structure is generated by a condensation reaction of a polycarboxylic acid and a cellulose derivative. The structure has limited expansion capacity in gastric juice, and may lose resistance to gastric pressure or gastric acid erosion after expansion, so it is relatively weak in prolonging gastric retention. Therefore, the present invention introduces anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts as support structures, so that the dietary fiber maintains a high expansion force in gastric juice, and at the same time, the mechanical strength and stability are significantly enhanced, providing a long-lasting feeling of fullness to the gastrointestinal tract. This innovative design is expected to play an important role in weight loss and diet control, and provide potential benefits for patients with obesity, obesity syndrome and diabetes.

Description

Technical Field

[0001] The invention relates to the field of food, health food or medical auxiliary technology, and in particular to a dietary fiber that can be used for weight management and has high expansion in gastric juice, and the preparation and application thereof. Background Art

[0002] Obesity is considered a global epidemic, and according to recent data from the World Health Organization, the prevalence of obesity has almost doubled in the past 40 years. Obesity is a major risk factor for many diseases, including cardiovascular disease, type 2 diabetes, hypertension and certain cancers, and is often associated with depression and social discrimination. Due to the huge health burden and economic pressure brought by obesity, finding effective ways to lose weight has become an important research topic in the health field.

[0003] Currently, various weight loss methods are emerging, such as diet control, exercise, and drug therapy. These methods have a positive effect on reducing weight and improving health to a certain extent. However, many weight loss methods have certain limitations. For example, diet control may cause malnutrition, exercise may face time and motivation limitations, and drug therapy may be accompanied by adverse reactions and dependence. Therefore, comprehensive evaluation and finding more effective and safe ways to lose weight have become an urgent need for current weight loss research and practice.

[0004] In the process of searching for new ways to lose weight, products made from dietary fiber that have a stomach volume effect are an emerging weight-loss material, and their application in weight loss has become a hot development direction. After modification, dietary fiber has a high water absorption capacity in water, and can quickly absorb water and swell in the stomach, thereby producing a volume effect and achieving a physical sense of fullness. This way of losing weight can achieve the goal of losing weight by reducing appetite and controlling food intake.

[0005] CN113854567A prepared a hydrogel, which is cross-linked by polysaccharide or its derivatives and dibasic acid, presenting a three-dimensional network of siphon capillaries, and has good water absorption and swelling effect. However, under the condition of gastric acid with a pH of 1.9, the water absorption multiple of this hydrogel is only 35-75 times, which is greatly affected by gastric acid, and the swelling force is relatively low, and the actual physical satiety provided is limited.

[0006] CN104622851B discloses a weight loss capsule and a preparation method thereof, comprising a gastric-soluble capsule shell or an enteric-soluble capsule shell, containing 5 to 20 polyurethane spherical particles, dipped in a water-soluble polymer adhesive, and maintaining the shape after drying. After entering the human body, the spherical particles gradually expand, absorb food and store it in the ball, and discharge it with the stool. But in essence, this method is similar to dieting without scientific monitoring. Excessive use of these capsules may lead to malnutrition, and too little use will make it difficult to provide sufficient satiety. Because they absorb nutrients randomly, it is difficult to accurately determine the appropriate dosage, and it is also difficult to coordinate with scientific dietary control.

[0007] Therefore, it is necessary to develop a product for weight management that still has high expansion in gastric juice, which can also stably absorb water in gastric juice and provide continuous pressure on the stomach wall and intestinal wall to provide a physical sense of fullness. Summary of the invention

[0008] In order to solve the shortcomings of the current weight-loss hydrogel technology, the present invention fills anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts as supporting materials on the basis of a three-dimensional network skeleton of cellulose or a cellulose derivative and a dibasic or polybasic carboxylic acid cross-linked product. It is found that it has a stronger three-dimensional network structure, and the gel strength is significantly better than that of a gel without a supporting material, and thus it has a good effect of providing a physical sense of fullness.

[0009] The first object of the present invention is to provide a dietary fiber that can be used for weight management and has high expansion in gastric juice. The dietary fiber is composed of a three-dimensional network skeleton of a cross-linked product of cellulose or a cellulose derivative and a dibasic or polybasic carboxylic acid, and an anionic polysaccharide, a cationic polysaccharide, and an inorganic calcium salt as a supporting structure.

[0010] A second object of the present invention is to provide a method for preparing dietary fiber that can be used for weight management and has high expansion in gastric juice, the method comprising the following steps:

[0011] a. dissolving cellulose or a cellulose derivative, a dibasic or polybasic carboxylic acid, an anionic polysaccharide, a cationic polysaccharide and an inorganic calcium salt in pure water in proportion to obtain a mixed solution;

[0012] b. drying the mixed solution to obtain a powder product of a certain mesh size;

[0013] c. placing the obtained powder in an oven to cause a cross-linking reaction to obtain the dietary fiber.

[0014] Cellulose or cellulose derivatives can undergo condensation reactions with dibasic or polybasic carboxylic acids, and the cross-linked products have good water absorption and swelling properties in neutral solutions. However, the structure may lose its ability to withstand gastric pressure or gastric acid erosion after it begins to swell, and the water absorption and swelling coefficient will decrease under the action of gastric acid. Therefore, in this case, the actual satiety effect of the single cross-linked product is low, and the effect of prolonging gastric retention is also quite limited. The present invention forms a stable three-dimensional network structure that can maintain high swelling power in gastric juice through the combined action of cellulose or cellulose derivatives and dibasic or polybasic carboxylic acid cross-linked products and anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts. Cellulose or cellulose derivatives undergo condensation reactions with dibasic or polybasic carboxylic acids, and the cross-linked products formed have good water absorption and swelling properties in neutral solutions. On this basis, the present invention further introduces anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts. Anionic polysaccharides and the above cross-linked products will further form an interlaced network structure. At the same time, when entering the gastric acid environment, such as Figure 1 As shown, the cationic polysaccharide chitosan and the inorganic calcium salt will dissociate and dissolve rapidly, and form a stable gel with the anionic polysaccharide through the charge effect, which is filled in the three-dimensional network skeleton, so that the above cross-linked product maintains mechanical stability while maintaining a high swelling ratio, providing the gastrointestinal tract with a long-lasting sense of fullness. And after the material contacts the matrix liquid, it can generate dispersed granules, which can mix with food as the gastrointestinal tract moves, does not affect the absorption of food, and will not aggregate together to block the gastrointestinal tract. After it reaches the colon environment, it loses the cross-linking site, the network molecular structure disappears, and it is gradually dissolved, and finally releases the absorbed water, and is excreted from the body as the intestine moves, and will not cause health hazards to the human body.

[0015] The third object of the present invention is to provide a preparation comprising any of the dietary fibers described above or any of the dietary fibers prepared by the methods described above.

[0016] The fourth object of the present invention is to provide an application of a dietary fiber that can be used for weight management and has high expansion in gastric juice. The dietary fiber can be used as a food for weight management, and can also be used to prepare food or medicine that prevents or treats obesity and diseases caused by obesity, including general food, special food, health food or medical equipment and other health products.

[0017] Beneficial effects of the present invention:

[0018] (1) The dietary fiber obtained by the present invention can maintain a high swelling force under gastric juice, and the introduced anionic polysaccharides and cationic polysaccharides (such as chitosan) and inorganic calcium salts attract each other through charge action to form a stable gel filled in a three-dimensional network structure, forming a gel structure that can maintain a high swelling rate in gastric juice and has high mechanical stability;

[0019] (2) The materials used in the present invention are common materials in food processing, are safe and harmless to the human body, and do not affect the digestion and absorption of food;

[0020] (3) The present invention can actually and effectively increase satiety and can be used as an effective means to assist in diet control and weight management. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a diagram of the structure of dietary fiber that expands highly in gastric juice. DETAILED DESCRIPTION

[0022] The present invention discloses a dietary fiber that can be used for weight management and has high expansion in gastric juice, and the dietary fiber is composed of a three-dimensional network structure and a support structure interlaced. The three-dimensional network structure is generated by a condensation reaction of a polycarboxylic acid and a cellulose derivative, but the structure has limited expansion capacity in gastric juice, and may lose resistance to gastric pressure or gastric acid erosion after expansion, so it is relatively weak in prolonging gastric retention. Therefore, the present invention introduces anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts as support structures, so that the dietary fiber maintains a high expansion force in gastric juice, while the mechanical strength and stability are significantly enhanced, providing a long-lasting feeling of fullness to the gastrointestinal tract. This innovative design is expected to play an important role in weight loss and diet control, and provide potential benefits for patients with obesity, obesity syndrome, and diabetes.

[0023] On the one hand, the present invention provides a dietary fiber that can be used for weight management and has high expansion in gastric juice. The dietary fiber is composed of a three-dimensional network skeleton of a cross-linked product of cellulose or a cellulose derivative and a dibasic or polybasic carboxylic acid, and an anionic polysaccharide, a cationic polysaccharide, and an inorganic calcium salt as a supporting structure.

[0024] The dietary fiber proposed by the present invention can absorb water and swell in a neutral solution, and can form a supporting structure when entering an acidic solution such as gastric juice, thereby improving its mechanical stability and still maintaining a high swelling force in gastric juice.

[0025] Optionally, in some embodiments of the present invention, the mass ratio of the cellulose or cellulose derivative to the dibasic or polybasic carboxylic acid is (500-1000):(1-5).

[0026] Further optionally, in some embodiments of the present invention, the mass ratio of the cellulose or cellulose derivative to the dibasic or polybasic carboxylic acid is (500-700):(1-5).

[0027] Further optionally, in some embodiments of the present invention, the mass ratio of the cellulose or cellulose derivative to the dibasic or polybasic carboxylic acid is (500-700):(1-3).

[0028] Optionally, in some embodiments of the present invention, the mass ratio of the cross-linked product to the anionic polysaccharide, the cationic polysaccharide, and the inorganic calcium salt is 160:(1-15):(0.5-3):(0.5-2).

[0029] Further optionally, in some embodiments of the present invention, the mass ratio of the cross-linked product to the anionic polysaccharide, the cationic polysaccharide, and the inorganic calcium salt is 160:(3-10):(0.9-2):(0.8-1.5).

[0030] Optionally, in some embodiments of the present invention, the cellulose or cellulose derivatives include at least one of sodium carboxymethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, and hydroxypropyl cellulose. The specific types of cellulose or cellulose derivatives are not limited in the embodiments of the present invention and all belong to the protection scope of the present invention.

[0031] Optionally, in some embodiments of the present invention, the dibasic or polybasic carboxylic acid includes at least one of citric acid, malic acid, tartaric acid, succinic acid, and fumaric acid. The types of specific dibasic or polybasic carboxylic acids are not limited in the embodiments of the present invention and all belong to the protection scope of the present invention.

[0032] Optionally, in some embodiments of the present invention, the anionic polysaccharide includes at least one of citrus fiber, pectin, konjac flour, flaxseed gum, sodium alginate, white kidney bean fiber, and oat fiber. The specific types of anionic polysaccharides are not limited in the embodiments of the present invention and all belong to the protection scope of the present invention.

[0033] Optionally, in some embodiments of the present invention, the cationic polysaccharide includes chitosan. The specific types of cationic polysaccharides are not limited in the embodiments of the present invention and all belong to the protection scope of the present invention.

[0034] Optionally, in some embodiments of the present invention, the inorganic calcium salt includes at least one of calcium carbonate, calcium silicate, and calcium sulfate. The specific types of inorganic calcium salts are not limited in the embodiments of the present invention and all belong to the protection scope of the present invention.

[0035] Optionally, in some embodiments of the present invention, at pH ≤ 2.0, the swelling power of the dietary fiber is higher than 200 g / g.

[0036] Further optionally, in some embodiments of the present invention, when pH ≤ 2.0, the swelling power of the dietary fiber is higher than 220 g / g.

[0037] Further optionally, in some embodiments of the present invention, when pH ≤ 2.0, the swelling power of the dietary fiber is 220-250 g / g.

[0038] Optionally, in some embodiments of the present invention, when pH ≤ 2.0, the storage modulus of the dietary fiber is higher than 10000 Pa.

[0039] Further optionally, in some embodiments of the present invention, when pH ≤ 2.0, the storage modulus of the dietary fiber is higher than 11000 Pa.

[0040] Further optionally, in some embodiments of the present invention, when pH ≤ 2.0, the storage modulus of the dietary fiber is 11000-12000 Pa.

[0041] On the other hand, the present invention also provides a method for preparing dietary fiber that is highly swellable in gastric juice, comprising the following steps:

[0042] a. dissolving cellulose or a cellulose derivative, a dibasic or polybasic carboxylic acid, an anionic polysaccharide, a cationic polysaccharide and an inorganic calcium salt in water to obtain a mixed solution;

[0043] b. drying the mixed solution at a temperature below 60° C. to obtain a powder;

[0044] c. Place the obtained powder in an oven at above 60°C to allow it to undergo a cross-linking reaction to obtain dietary fiber.

[0045] Optionally, in some embodiments of the present invention, in step (a), the ratio of the added solids to pure water is less than 1:10.

[0046] Further optionally, in some embodiments of the present invention, in step (a), the ratio of the added solid to pure water is 1:10-20.

[0047] Optionally, in some embodiments of the present invention, in step (b), the particle size of the powder is 20-80 mesh.

[0048] Further optionally, in some embodiments of the present invention, in step (b), the particle size of the powder is 20-40 mesh.

[0049] Optionally, in some embodiments of the present invention, in step (b), the drying method includes one of spray drying, vacuum drying, freeze drying, rake drying, and air drying.

[0050] Optionally, in some embodiments of the present invention, in step (c), the cross-linking temperature is 60-150° C., and the cross-linking time is 4-8 h.

[0051] Further optionally, in some embodiments of the present invention, in step (c), the cross-linking temperature is 80-130° C., and the cross-linking time is 4-8 h.

[0052] On the other hand, the present invention also provides a preparation, which comprises any dietary fiber as described above or the dietary fiber obtained by any preparation method as described above.

[0053] Optionally, in some embodiments of the present invention, the preparation is in the form of granules, or is loaded in an enteric-coated or gastric-coated capsule.

[0054] On the other hand, the present invention also provides the use of any of the dietary fibers described above, or the dietary fibers obtained by any of the preparation methods described above, or the preparations described above, wherein the use includes the use for preparing food or medicine for preventing or treating obesity and diseases caused by obesity.

[0055] Optionally, in some embodiments of the present invention, the food includes ordinary food, special food or health food.

[0056] The specific embodiments of the present invention are described below, and it should be understood that the embodiments are for better explanation of the present invention and are not intended to limit the present invention. According to the following embodiments, the present invention can be better understood. However, it is easy for those skilled in the art to understand that the specific material proportions, process conditions and results described in the embodiments are only used to illustrate the present invention, and should not and will not limit the present invention described in detail in the claims.

[0057] Embodiment 1:

[0058] Take 0.06g of malic acid and add it to 500mL of ultrapure water, stir and dissolve, then add 30g of sodium carboxymethyl cellulose and stir and dissolve, then add 0.9g of citrus fiber, 0.9g of sodium alginate, 0.19g of calcium carbonate and 0.36g of chitosan and stir and disperse evenly, then place the solution in a forced air drying oven to dry, dry at 50°C, and after drying, crush and sieve to obtain 20-40 mesh particles, cross-link in a forced air drying oven at 90°C for 6h to obtain the dietary fiber product of this embodiment.

[0059] Embodiment 2:

[0060] Take 0.15g of malic acid and add it to 500mL of ultrapure water, stir and dissolve it, then add 30g of sodium carboxymethyl cellulose and stir and dissolve it, then add 0.38g of pectin, 0.38g of sodium alginate, 0.19g of calcium carbonate and 0.19g of chitosan and stir and disperse them evenly, then freeze the solution and freeze-dry it. After drying, crush and sieve to obtain 40-80 mesh particles, place the particles in a 60°C forced air drying oven for cross-linking for 4h to obtain the dietary fiber product of this embodiment.

[0061] Comparative Example 1:

[0062] Except that anionic polysaccharide citrus fiber and sodium alginate, cationic polysaccharide chitosan and inorganic calcium salt calcium carbonate were not added, the remaining steps were consistent with Example 1.

[0063] Take 0.06g of malic acid and add it to 500mL of ultrapure water, stir and dissolve it, then add 30g of sodium carboxymethyl cellulose and stir and dissolve it, then place the solution in a forced air drying oven to dry, dry it at 50°C, crush and sieve to obtain 20-40 mesh particles after drying, cross-link it in a forced air drying oven at 90°C for 6h, and obtain the dietary fiber product of the present invention.

[0064] Comparative Example 2:

[0065] Except that the anionic polysaccharide pectin and sodium alginate, the cationic polysaccharide chitosan and the inorganic calcium salt calcium carbonate were not added, the remaining steps were consistent with those of Example 2.

[0066] Take 0.15g of malic acid and add it to 500mL of ultrapure water, stir and dissolve it, then add 30g of sodium carboxymethyl cellulose and stir and dissolve it, then freeze the solution and freeze-dry it, after drying, crush and sieve to obtain 40-80 mesh particles, place the particles in a 60°C forced air drying oven for cross-linking for 4h, and obtain the dietary fiber product of the present invention.

[0067] Comparative Example 3:

[0068] Except that the anionic polysaccharides pectin and sodium alginate and the cationic polysaccharide chitosan were not added, the remaining steps were consistent with those in Example 1.

[0069] Take 0.06g of malic acid and add it to 500mL of ultrapure water, stir and dissolve it, then add 30g of sodium carboxymethyl cellulose and stir and dissolve it, then add 0.19g of calcium carbonate and stir and disperse it evenly, then place the solution in a blast drying oven to dry, dry it at 50°C, and after drying, crush and sieve to obtain 20-40 mesh particles, cross-link them in a 90°C blast drying oven for 6h to obtain the dietary fiber product of this comparative example.

[0070] Comparative Example 4:

[0071] Except that inorganic calcium salt calcium carbonate is not added, the remaining steps are consistent with Example 1.

[0072] Take 0.06g of malic acid and add it to 500mL of ultrapure water, stir and dissolve, then add 30g of sodium carboxymethyl cellulose and stir and dissolve, then add 0.9g of citrus fiber, 0.9g of sodium alginate and 0.36g of chitosan and stir and disperse evenly, then place the solution in a forced air drying oven to dry at 50°C, and after drying, crush and sieve to obtain 20-40 mesh particles, cross-link in a forced air drying oven at 90°C for 6h to obtain the dietary fiber product of this comparative example.

[0073] The test results of the embodiments and comparative examples are as follows:

[0074] 1. Determination of expansion force and storage modulus

[0075] Swelling power is often used to evaluate the ability of a certain mass of material to absorb solution and expand. The greater the swelling power, the stronger the material's ability to absorb solution and the larger the expansion volume. Therefore, the greater the swelling power of edible materials, the stronger their ability to increase satiety.

[0076] The storage modulus is an indicator to measure the energy storage capacity of a material when subjected to force. The higher the storage modulus, the higher the mechanical strength and stability of the material.

[0077] Weigh a certain mass of sample, immerse it in artificial gastric acid simulation solution (pH 1.2), place it at 37°C for 30 minutes, filter it and weigh it, and calculate the swelling force according to the following formula:

[0078]

[0079] Where m1 is the mass of dietary fiber after absorbing water and swelling after filtration, and m0 is the mass of the weighed sample.

[0080] The filtered sample was placed on a rheometer with a fixed tension of 0.1% and a frequency range of 1-50 rad / s. The frequency of 10 rad / s was taken to correspond to the storage modulus (Pa).

[0081] The test results are shown in Table 1:

[0082] Table 1 Expansion power of dietary fiber in the embodiments and comparative examples

[0083]

[0084]

[0085] From the results in Table 1, it can be seen that the swelling force and storage modulus of the dietary fiber of the embodiment are higher than those of the dietary fiber of the comparative example, indicating that the dietary fiber prepared by the embodiment of the present invention has a higher swelling force under gastric acid conditions, and the gel after swelling in gastric juice has higher mechanical strength and better stability. The anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts introduced in the embodiment play a good supporting role in the three-dimensional network structure of the dietary fiber, so that it can withstand the peristaltic pressure of the gastric wall and the erosion of gastric juice.

[0086] 2. Animal Experiments

[0087] The experimental group mice were gavaged with the dietary fiber prepared in the above embodiment and the comparative example (daily dose: 4 g / 50 kg body weight), and the control group was gavaged with the same dose of maltodextrin, and other dietary conditions remained the same. The changes in food intake and body weight of the experimental group compared with the control group were monitored weekly for 4 consecutive weeks. The specific results are shown in Tables 2 and 3:

[0088] Table 2 Changes in food intake of mice after dietary fiber intervention in the examples and comparative examples compared with the control group

[0089] Food intake Week 1 Week 2 Week 3 Week 4 Example 1 -25.6％ -29.6％ -30.9％ -29.8％ Example 2 -23.2％ -26.6％ -29.5％ -30.3％ Comparative Example 1 -5.9％ -3.1％ -1.5％ -2.0％ Comparative Example 2 -4.6％ -2.6％ -5.1％ -2.3％

[0090] Table 3 Body weight changes of mice after dietary fiber intervention in the examples and comparative examples compared with the control group

[0091] Food intake Week 1 Week 2 Week 3 Week 4 Example 1 -3.5％ -8.9％ -10.6％ -16.7％ Example 2 -3.3％ -8.7％ -10.2％ -16.1％ Comparative Example 1 -0.3％ -0.4％ -0.4％ -0.5％ Comparative Example 2 -0.2％ -0.4％ -0.4％ -0.4％

[0092] It can be found from the animal experiment data of Table 2 and Table 3 that after the dietary fiber obtained by the embodiment was used to intervene in mice, the food intake and body weight of mice were significantly decreased compared with the control group, while after the dietary fiber obtained by the comparative example was intervened, the food intake and body weight of mice did not change significantly. The dietary fiber obtained by the embodiment has higher mechanical strength and stability in the actual gastrointestinal digestion process, and has a more obvious satiety effect, so that the food intake of mice is reduced, and the body weight is continuously reduced within 4 weeks. This once again illustrates that the anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts introduced in the embodiment that have a supporting effect on the three-dimensional structure of dietary fiber greatly enhance the satiety effect of dietary fiber. The dietary fiber obtained by the present invention can be used for food for weight management, and also provides a new solution for preparing special foods, health foods, or medical devices and other large health products with the prevention or treatment of obesity and diseases caused by obesity.

[0093] Although the present invention has been disclosed as above in the form of a preferred embodiment, it is not intended to limit the present invention. Anyone familiar with this technology can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be based on the definition of the claims.

Claims

1. A dietary fiber that can be used for weight management and has high expansion in gastric juice, characterized in that: The dietary fiber is composed of a three-dimensional network skeleton of cellulose or a cellulose derivative and a dibasic or polybasic carboxylic acid cross-linked product, and anionic polysaccharides, cationic polysaccharides, and inorganic calcium salts as a supporting structure; The mass ratio of the cellulose or cellulose derivative and the dibasic or polybasic carboxylic acid is (500-700):(1-3); The mass ratio of the cross-linked product to the anionic polysaccharide, the cationic polysaccharide, and the inorganic calcium salt is 160: (3-10): (0.9-2): (0.8-1.5); The cellulose or cellulose derivative is sodium carboxymethyl cellulose; The dibasic or polybasic carboxylic acid is malic acid; The anionic polysaccharide comprises at least one of citrus fiber, pectin, and sodium alginate; The cationic polysaccharide comprises chitosan; The inorganic calcium salt includes at least one of calcium carbonate, calcium silicate and calcium sulfate; The method for preparing the dietary fiber that can be used for weight management and highly expands in gastric juice comprises the following steps: a. dissolving cellulose or a cellulose derivative, a dibasic or polybasic carboxylic acid, an anionic polysaccharide, a cationic polysaccharide and an inorganic calcium salt in water to obtain a mixed solution; the weight ratio of the total amount of cellulose or a cellulose derivative, a dibasic or polybasic carboxylic acid, an anionic polysaccharide, a cationic polysaccharide and an inorganic calcium salt to water is 1: (10-20); b. drying the mixed solution at a temperature below 60° C. to obtain a powder; c. Place the obtained powder in an oven at 60-150°C to allow it to undergo a cross-linking reaction for 4-8 hours to obtain dietary fiber.

2. The dietary fiber according to claim 1, characterized in that The powder particle size of step (b) is 20-80 mesh.

3. The dietary fiber according to claim 1, characterized in that When pH≤2.0, the swelling power of the dietary fiber is higher than 100 g / g.

4. The dietary fiber according to claim 1, characterized in that The storage modulus of the dietary fiber is higher than 10000 Pa.

5. A preparation, characterized in that The preparation comprises the dietary fiber as claimed in any one of claims 1 to 4, and the preparation is in the form of granules, or loaded in enteric-coated or gastric-coated capsules.

6. Use of the dietary fiber according to any one of claims 1 to 4 or the preparation according to claim 5, characterized in that: The application includes the use for preparing medicines for preventing or treating obesity and diseases caused by obesity.

7. Use of the dietary fiber according to any one of claims 1 to 4 or the preparation according to claim 5, characterized in that: The application includes use in food, and the food includes ordinary food, special food or health food.

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