Skin whitening and moisturizing cream and preparation method thereof

Abstract

The present disclosure provides a skin whitening and moisturizing cream, comprising the following raw materials in parts by weight: 10-13 parts of niacinamide capsules, 20-21 parts of vitamin C, 5-10 parts of acai berry extract, 10-20 parts of yam root extract, 5-10 parts of ginkgo extract, 1-3 parts of tocopherol, 65-75 parts of lipid base, and 1-5 parts of water. The core material of the niacinamide capsule is niacinamide stock solution, and the packaging material is a polysaccharide gel film. Long-term use has good whitening and moisturizing effects.

Description

Technical Field

[0001] The invention relates to the technical field of skin care products, and in particular to a skin whitening and moisturizing cream and a preparation method thereof. Background Art

[0002] As an effective whitening ingredient, vitamin C reduces the production of melanin by interacting with the active site of tyrosinase. It can also act as a reducing agent for dopamine in the process of melanin synthesis, which can reduce the production of melanin. It is a safe and effective skin whitening agent. Niacinamide intercepts melanin and prevents it from being transmitted to the upper layer of the epidermis, so the skin will not darken, achieving the whitening effect. The intercepted melanin will be decomposed and metabolized normally and will not accumulate in the basal layer.

[0003] Vitamin C and niacinamide can act on the two stages of skin darkening. The synergistic use of the two can achieve a better whitening effect. However, for the whitening effect, vitamin C needs to work in an acidic environment with a pH value of less than 3. Niacinamide is stable at a pH value of 5-7 and can have a whitening effect, so it is difficult to put the two ingredients in the same whitening product.

[0004] At the same time, the whitening process can be summarized as follows: 1. Inhibit tyrosinase activity; 2. Reduce already synthesized melanin; 3. Inhibit melanin transport; 4. Accelerate the shedding of keratin; 5. Further skin growth; 6. Sun protection, vitamin C and niacinamide cannot cover the entire whitening process. Summary of the invention

[0005] The present invention provides a skin whitening and moisturizing cream, which can act on different stages of whitening and achieve a good whitening effect. The cream is characterized in that it comprises the following raw materials in parts by weight: 10-13 parts of niacinamide capsules, 20-21 parts of vitamin C, 5-10 parts of acai berry extract, 10-20 parts of yam root extract, 5-10 parts of ginkgo extract, 1-3 parts of tocopherol, 65-75 parts of lipid base, 1-5 parts of water, the core material of the niacinamide capsule is niacinamide stock solution, and the packaging material is dextran gel film.

[0006] The skin whitening and moisturizing cream provided by the present disclosure can act on different stages of whitening. The whitening process is as follows: 1. Inhibit tyrosinase activity; 2. Reduce melanin that has been synthesized; 3. Inhibit melanin transport; 4. Accelerate the shedding of keratin; 5. Further skin growth; 6. Sun protection. The present disclosure constructs niacinamide capsules to allow niacinamide to exist in an acidic system, so that niacinamide and vitamin C can be placed in the same whitening system, so that vitamin C has the effect of inhibiting tyrosinase. The more obvious effect is to reduce the melanin that has been synthesized. Niacinamide acts on the third stage to inhibit melanin transport. At the same time, a lipid base is used to reduce the shaking of niacinamide capsules in the cream and reduce the possibility of niacinamide capsules breaking. On the other hand, compared with lotions, it has better moisturizing effect. Dextran has a moisturizing effect when used as a film in cosmetics. The components extracted and separated from acai berries contain a variety of whitening active ingredients, among which anthocyanins, glycosides, catechins, ferulic acid, and ellagic acid all have skin whitening effects and can be used as TRY activity inhibitors and scavenger free radicals. Reduce the expression of melanocytes and TRY, and reduce the production of melanin. Therefore, the acai berry extract can work together with vitamin C to inhibit the activity of tyrosinase, act in the first stage, and enhance the inhibitory effect on the activity of tyrosinase. The peroxidase therein can remove skin scars, moisturize the skin, and help the regeneration of keratin after shedding, and act in the fifth stage. The flavonoids in the ginkgo extract can absorb ultraviolet rays and have a sunscreen effect, and act in the sixth stage. Since the skin itself has a mechanism for shedding keratin, the ingredients disclosed in the present invention act on the skin, can cover different stages of whitening, synergize with each other, and act in different stages of whitening, thereby optimizing the whitening effect, achieving a whitening effect that is better than a single ingredient, and enhancing the whitening effect.

[0007] Optionally, the lipid base includes one or more ingredients selected from the group consisting of lanolin, horse fat, coconut fat, and glycolipids.

[0008] Lanolin, horse fat, coconut oil, and glycolipids all have good moisturizing effects and have poor fluidity at room temperature. The selection of the above ingredients can, on the one hand, provide better moisturizing effects, and on the other hand, can slow down the shaking of niacinamide capsules and reduce the possibility of niacinamide capsules breakage.

[0009] Optionally, each portion of the lipid base comprises the following raw materials in parts by weight: 10-15 parts of lanolin, 1-5 parts of glycolipids, 3-5 parts of fenugreek oil, 1-2 parts of sorbitan octanoate, and 1-3 parts of polyaminopropyl biguanide.

[0010] Fenugreek oil is used on the skin to nourish the skin and alleviate the aging process of the skin. The other lanolin works together. After the fenugreek oil nourishes the skin, the lanolin locks in moisture to achieve a long-term moisturizing effect.

[0011] Optionally, the skin whitening and moisturizing cream also includes an acidic substance, and the acidic substance is one of azelaic acid, A acid, salicylic acid, glycolic acid, and lactobionic acid.

[0012] Increase acidic substances to exfoliate the skin, making it easier for subsequent whitening and moisturizing ingredients to take effect.

[0013] Optionally, the acid substance is 5-7 parts by weight of azelaic acid.

[0014] In addition to the exfoliating ability of conventional acids, it can also inhibit abnormal melanin and has a whitening effect.

[0015] Optionally, the weight ratio of the core material to the packaging material of the nicotinamide capsule is (2-5):1.

[0016] The wall thickness of the niacinamide capsule is controlled so that it can wrap the niacinamide while preventing the packaging material from being too thick to release the niacinamide.

[0017] Optionally, the one part by weight of the glucan gel film comprises the following raw materials in parts by weight: 1-2 parts of glycerol, 8-10 parts of glucan solution, and 0.1-0.5 parts of peony root extract.

[0018] Glycerin acts as a plasticizer while moisturizing, and peony root extract can act as an antibacterial agent and also has a whitening effect, enhancing the whitening effect.

[0019] In another aspect, the present disclosure provides a preparation process of a skin whitening and moisturizing cream, comprising the following steps:

[0020] A. Mix the lipid base raw materials, raise the temperature to 70 degrees Celsius, melt the raw materials, and stir evenly to obtain a lipid base;

[0021] B. Lower the temperature of the lipid base to 50 degrees Celsius, add water, tocopherol, vitamin C, acai berry extract, and yam root extract, mix well, and fill into finished product containers;

[0022] C. Prepare nicotinamide capsules, add the nicotinamide capsules to the system obtained in step B, and stir to make the nicotinamide capsules evenly distributed in the system;

[0023] D. Rapidly cool the finished product obtained in step C to room temperature.

[0024] Optionally, the preparation process of the skin whitening and moisturizing cream, the specific steps of preparing nicotinamide capsules include:

[0025] C1. Mix glycerol, dextran solution and peony root extract into water and dissolve them to obtain a packaging material mixture;

[0026] C2. Pour the mixed packaging material solution into a spherical mold with a filling port, shake the spherical mold to make the mixed packaging material solution cover the inner wall of the spherical mold, pour out the excess solution that has not covered the wall, let it stand until the water evaporates, repeat the process several times to obtain the target thickness, and obtain the packaging material with a filling port;

[0027] C3. Pour the nicotinamide stock solution into the packaging material with a filling port through the filling port;

[0028] C4. Pour the mixed packaging material liquid at the filling port, allow the water to evaporate naturally to seal the filling port, and then demould to obtain nicotinamide capsules.

[0029] Optionally, in step D, the temperature is rapidly reduced to room temperature by spraying an appropriate amount of liquid nitrogen.

[0030] Through this method, niacinamide capsules can be prepared. At the same time, the niacinamide capsules can be stably placed in vitamin C and coexist with other active ingredients. They can act on the entire whitening stage and enhance the whitening effect.

[0031] Other features and advantages of the present disclosure will be described in detail in the following detailed description. DETAILED DESCRIPTION

[0032] The specific embodiments of the present disclosure are described in detail below. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present disclosure, and are not used to limit the present disclosure.

[0033] Preparation example:

[0034] Preparation Example 1:

[0035] The dextran gel film comprises the following raw materials in parts by weight: 1 part of glycerol, 10 parts of dextran solution, and 0.5 parts of peony root extract.

[0036] Nicotinamide capsules were prepared by the following steps:

[0037] 1. Mix glycerol, dextran solution and peony root extract into water and dissolve them to obtain a packaging material mixture;

[0038] 2. Pour the mixed packaging material into a spherical mold with a filling port, shake the spherical mold to make the mixed packaging material cover the inner wall of the spherical mold, pour out the excess solution that has not covered the wall, let it stand until the water evaporates, repeat several times to obtain the target thickness, and obtain the packaging material with a filling port;

[0039] 3. Pour the niacinamide stock solution into the packaging material with a filling port through the filling port;

[0040] 4. Pour the packaging material mixture at the filling port, ensure that the weight ratio of the core material and the packaging material of the nicotinamide capsule is 2:1, allow the water to evaporate naturally to seal the filling port, and obtain the nicotinamide capsule after demoulding.

[0041] Preparation Example 2:

[0042] The dextran gel film comprises the following raw materials in parts by weight: 2 parts of glycerol, 8 parts of dextran solution, and 0.1 parts of peony root extract.

[0043] Nicotinamide capsules were prepared by the following steps:

[0044] 1. Mix glycerol, dextran solution and peony root extract into water and dissolve them to obtain a packaging material mixture;

[0045] 2. Pour the mixed packaging material into a spherical mold with a filling port, shake the spherical mold to make the mixed packaging material cover the inner wall of the spherical mold, pour out the excess solution that has not covered the wall, let it stand until the water evaporates, repeat several times to obtain the target thickness, and obtain the packaging material with a filling port;

[0046] 3. Pour the niacinamide stock solution into the packaging material with a filling port through the filling port;

[0047] 4. Pour the packaging material mixture at the filling port, allow the water to evaporate naturally and seal the filling port, ensuring that the weight ratio of the core material and the packaging material of the niacinamide capsule is 5:1, and obtain the niacinamide capsule after demoulding.

[0048] Example:

[0049] Example 1

[0050] A skin whitening and moisturizing cream comprises the following raw materials in parts by weight: 10 parts of niacinamide capsules prepared in Preparation Example 1, 20 parts of vitamin C, 5 parts of acai berry extract, 10 parts of yam root extract, 5 parts of ginkgo extract, 1 part of tocopherol, 65 parts of lipid base, 1 part of water, and 5 parts of azelaic acid. The core material of the niacinamide capsule is niacinamide stock solution, and each part of the lipid base comprises the following raw materials in parts by weight: 15 parts of lanolin, 5 parts of glycolipid, 5 parts of fenugreek oil, 2 parts of sorbitan octanoate, and 3 parts of polyaminopropyl biguanide. The packaging material is a dextran gel film.

[0051] The preparation was carried out using the following steps:

[0052] A. Mix the lipid base raw materials, raise the temperature to 70 degrees Celsius, melt the raw materials, and stir evenly to obtain a lipid base;

[0053] B. Lower the temperature of the lipid base to 50 degrees Celsius, add water, tocopherol, vitamin C, acai berry extract, and yam root extract, mix well, and fill into finished product containers;

[0054] C. Prepare nicotinamide capsules, add the nicotinamide capsules to the system obtained in step B, and stir to make the nicotinamide capsules evenly distributed in the system;

[0055] D. The finished product obtained in step C is rapidly cooled to room temperature by spraying liquid nitrogen.

[0056] Example 2

[0057] A skin whitening and moisturizing cream comprises the following raw materials in parts by weight: 13 parts of niacinamide capsules prepared in Preparation Example 1, 21 parts of vitamin C, 10 parts of acai berry extract, 20 parts of yam root extract, 10 parts of ginkgo extract, 3 parts of tocopherol, 75 parts of lipid base, 5 parts of water, and 7 parts of azelaic acid. The core material of the niacinamide capsule is niacinamide stock solution, and each part of the lipid base comprises the following raw materials in parts by weight: 10 parts of lanolin, 1 part of glycolipid, 3 parts of fenugreek oil, 1 part of sorbitan octanoate, and 1 part of polyaminopropyl biguanide. The packaging material is a dextran gel film.

[0058] The preparation was carried out using the following steps:

[0059] C. Mix the lipid base raw materials, raise the temperature to 70 degrees Celsius, melt the raw materials, and stir evenly to obtain a lipid base;

[0060] D. Lower the temperature of the lipid base to 50 degrees Celsius, add water, tocopherol, vitamin C, acai berry extract, and yam root extract, mix well, and fill into finished product containers;

[0061] C. Prepare nicotinamide capsules, add the nicotinamide capsules to the system obtained in step B, and stir to make the nicotinamide capsules evenly distributed in the system;

[0062] D. The finished product obtained in step C is rapidly cooled to room temperature by spraying liquid nitrogen.

[0063] Example 3

[0064] A skin whitening and moisturizing cream comprises the following raw materials in parts by weight: 12 parts of niacinamide capsules prepared in Preparation Example 1, 20.5 parts of vitamin C, 7 parts of acai berry extract, 15 parts of yam root extract, 7 parts of ginkgo extract, 2 parts of tocopherol, 70 parts of lipid base, 3 parts of water, and 6 parts of azelaic acid. The core material of the niacinamide capsule is niacinamide stock solution, and each part of the lipid base comprises the following raw materials in parts by weight: 12 parts of lanolin, 3 parts of glycolipid, 4 parts of fenugreek oil, 1.5 parts of sorbitan octanoate, and 2 parts of polyaminopropyl biguanide. The packaging material is a dextran gel film.

[0065] The preparation was carried out using the following steps:

[0066] E. Mix the lipid base raw materials, raise the temperature to 70 degrees Celsius, melt the raw materials, and stir evenly to obtain a lipid base;

[0067] F. Lower the temperature of the lipid base to 50 degrees Celsius, add water, tocopherol, vitamin C, acai berry extract, and yam root extract, stir evenly, and fill into finished product containers;

[0068] C. Prepare nicotinamide capsules, add the nicotinamide capsules to the system obtained in step B, and stir to make the nicotinamide capsules evenly distributed in the system;

[0069] D. The finished product obtained in step C is rapidly cooled to room temperature by spraying liquid nitrogen.

[0070] Example 4

[0071] The difference from Example 3 is that the nicotinamide capsules prepared in Preparation Example 2 were used.

[0072] Example 5

[0073] The difference from Example 3 is that fenugreek oil is not included in the lipid base.

[0074] Example 6

[0075] The difference from Example 3 is that no acid substance is used.

[0076] Comparative Example 1

[0077] The difference from Example 3 is that the nicotinamide capsules are replaced with an equal amount of nicotinamide.

[0078] Comparative Example 2

[0079] The difference from Example 3 is that nicotinamide capsules are not added.

[0080] Comparative Example 3

[0081] The difference from Example 3 is that vitamin C is not added.

[0082] Comparative Example 4

[0083] The difference from Example 3 is that no acai berry extract is added.

[0084] Comparative Example 5

[0085] The difference from Example 3 is that no yam root extract is added.

[0086] Comparative Example 6

[0087] The difference from Example 3 is that no ginkgo extract is added.

[0088] Comparative Example 7

[0089] The difference from Example 3 is that the lipid base is replaced with a water base.

[0090] Comparative Example 8

[0091] The difference from Example 3 is that fenugreek oil is not added.

[0092] In order to verify the whitening effect on human skin, the following experiment was conducted on 50 healthy men and women: an opaque tape with twelve holes with a diameter of 1.5 cm was attached to the upper arm of each tester, and then the attached part of each tester was irradiated with ultraviolet light, and the radiation dose was 1.5 times the minimum erythema dose to induce skin darkening. After ultraviolet radiation, the embodiment and the comparative example were applied to the irradiated part respectively. Two months later, the skin color was measured using a colorimeter purchased on the market.

[0093] The effect of each component is judged by determining the "L" value indicating the lightness and darkness of the skin. In the present invention, the "L" value is calibrated by a standard plate, and the measurement is repeated multiple times in one part to uniformly measure the pigment deposition part. The skin color difference (△L) between the time point when the composition is applied and the time point when the composition is applied is completed is calculated according to the following formula: △L=brightness L after two months of the experiment-brightness L at the beginning of the experiment. The results are shown in Table 2.

[0094] Skin stratum corneum hydration rate test: The working principle is to use a capacitor as the instrument probe. Since water is the substance with the largest dielectric constant on the skin, when the skin moisture content changes, the skin capacitance value also changes. Therefore, the skin surface moisture content can be analyzed by measuring the skin capacitance value. The commonly used instrument is Corneometer CM825. By measuring the change in the skin stratum corneum capacitance value before and after using the product, the change in the stratum corneum water content is measured, thereby evaluating the moisturizing effect of the cosmetics. This method quantifies the moisture content of the skin stratum corneum, can sensitively respond to changes in the skin moisture content, and has good reproducibility. It is currently one of the commonly used methods for evaluating the efficacy of moisturizing cosmetics.

[0095] Experimental method: Twelve 1x1cm squares were cut on the flexion side of the left and right forearms of the examinee. 2 The left arm was used as the test area for moisturizing products, and the corresponding symmetrical area on the right arm was used as the blank control. The moisture content of each test area was tested with Corneometer CM825 at 6 hours and repeated 5 times to obtain the average value. The hydration rate was calculated using formula (1).

[0096] Hydration rate = (test value - blank value) / blank value x 100%

[0097] Table 1 Whitening effect and hydration rate of Examples 1-6 and Comparative Examples 1-8

[0098] Whitening effect △L Hydration rate Example 1 2.1 50% Example 2 2.3 51% Example 3 2.1 52% Example 4 1.7 48% Example 5 1.8 53% Example 6 1.7 50% Comparative Example 1 1.3 47% Comparative Example 2 1.2 49% Comparative Example 3 1.2 51% Comparative Example 4 1.1 50% Comparative Example 5 1.1 47% Comparative Example 6 1.2 49% Comparative Example 7 1.6 32% Comparative Example 8 2.0 34%

[0099] Based on Table 1, by comparing the whitening effects of Examples 1-6 with those of Comparative Examples 1-8, it can be seen that the minimum whitening effect of Examples 1-6 is 1.7, and the maximum whitening effect is 2.3, which is better than the minimum value of 1.1 and the maximum value of 1.3 of Comparative Examples 1-6. It can be seen that, under different ratios disclosed in the present invention, good whitening effects can be achieved.

[0100] The whitening effect value of Example 3 is 2.1, which is significantly better than 1.3 of Comparative Example 1. Therefore, it can be seen that adding nicotinamide in the form of nicotinamide capsules is better than directly adding nicotinamide, which has a significant effect on whitening. The whitening effect value of Example 3 is 2.1, which is significantly better than 1.2 of Comparative Example 1. Therefore, it can be seen that adding nicotinamide in the form of nicotinamide capsules has a significant effect on whitening. Combining the comparison between Comparative Examples 1-2 and Example 3, it can be seen that nicotinamide has a significant effect on whitening, and adding nicotinamide in the form of nicotinamide capsules to this system can reduce the possibility of nicotinamide inactivation, and obtain a better whitening effect.

[0101] The whitening effect value of Example 3 is 2.1, which is significantly better than 1.2 of Comparative Example 3. Therefore, it can be seen that the addition of vitamin C has a significant effect on whitening.

[0102] By comparing Comparative Examples 2-3 with Example 3, it can be seen that the combined effect of vitamin C and niacinamide is better than that of a single ingredient.

[0103] The whitening effect value of Example 3 is 2.1, which is significantly better than 1.1 of Comparative Example 4. Therefore, it can be seen that the addition of acai berry extract has a significant effect on whitening.

[0104] The whitening effect value of Example 3 is 2.1, which is significantly better than 1.1 of Comparative Example 5. Therefore, it can be seen that adding yam root extract has a significant effect on whitening.

[0105] The whitening effect value of Example 3 is 2.1, which is significantly better than 1.2 of Comparative Example 6. Therefore, it can be seen that the addition of Ginkgo extract has a significant effect on whitening.

[0106] By comparing Comparative Examples 4-6 with Example 3, it can be seen that the combined effect of acai berry extract, yam root extract, and ginkgo extract is better than that of a single ingredient.

[0107] Combining Examples 1-6 with Comparative Examples 7-8, the hydration rate in Examples 1-6 is as low as 48% and as high as 53%, which is significantly higher than 32% of Comparative Example 7 and 34% of Comparative Example 8. Therefore, it can be seen that the formula of the present disclosure has a good moisturizing effect.

[0108] The hydration rate value of Example 3 is 52%, which is significantly better than 32% of Comparative Example 7. Therefore, it can be seen that the moisturizing effect of the lipid base is better than that of the water base.

[0109] The hydration rate value of Example 3 is 52%, which is significantly better than 34% of Comparative Example 8. Therefore, it can be seen that the addition of fenugreek oil has a significant effect on moisturizing.

[0110] The above embodiments are preferred implementation schemes of the present invention. In addition, the present invention may also be implemented in other ways. Any obvious replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. A skin whitening and moisturizing cream, characterized in that: The composition comprises the following raw materials in parts by weight: Nicotinamide capsules 10-13 servings Vitamin C 20-21 parts Acai berry extract 5-10 parts 10-20 parts of Chinese Yam Root Extract Ginkgo extract 5-10 parts Tocopherol 1-3 parts Lipid base 65-75 parts 1-5 parts water The core material of the nicotinamide capsule is nicotinamide stock solution, and the packaging material is dextran gel film. Each portion of the lipid base includes the following raw materials in parts by weight: Lanolin 10-15 parts 1-5 parts of glycolipid 3-5 parts fenugreek oil 1-2 parts of sorbitan octanoate 1-3 parts of polyaminopropyl biguanide, The specific steps of preparing nicotinamide capsules include: C1. Mix glycerol, dextran solution and peony root extract into water and dissolve them to obtain a packaging material mixture; C2. Pour the mixed packaging material solution into a spherical mold with a filling port, shake the spherical mold to make the mixed packaging material solution cover the inner wall of the spherical mold, pour out the excess solution that has not covered the wall, let it stand until the water evaporates, repeat the process several times to obtain the target thickness, and obtain the packaging material with a filling port; C3. Pour the nicotinamide stock solution into the packaging material with a filling port through the filling port; C4. Pour the mixed packaging material liquid at the filling port, allow the water to evaporate naturally to seal the filling port, and then demould to obtain nicotinamide capsules.

2. The skin whitening and moisturizing cream according to claim 1, characterized in that: The skin whitening and moisturizing cream also includes an acidic substance, and the acidic substance is one of azelaic acid, A acid, salicylic acid, glycolic acid, and lactobionic acid.

3. The skin whitening and moisturizing cream according to claim 2, characterized in that: The acid substance is composed of 5-7 parts by weight of azelaic acid.

4. The skin whitening and moisturizing cream according to claim 1, characterized in that: The weight ratio of the core material to the packaging material of the nicotinamide capsule is (2-5):

1.

5. The skin whitening and moisturizing cream according to claim 1, characterized in that: The one weight portion of the dextran gel film comprises the following raw materials in weight portions: 1-2 parts glycerin 8-10 parts of dextran solution Peony root extract 0.1-0.5 parts.

6. A process for preparing the skin whitening and moisturizing cream according to any one of claims 1 to 5, characterized in that: The following steps are included: A. Mix the lipid base raw materials, raise the temperature to 70 degrees Celsius, melt the raw materials, and stir evenly to obtain a lipid base; B. Lower the temperature of the lipid base to 50 degrees Celsius, add water, tocopherol, vitamin C, acai berry extract, and yam root extract, mix well, and fill into finished product containers; C. Prepare nicotinamide capsules, add the nicotinamide capsules to the system obtained in step B, and stir to make the nicotinamide capsules evenly distributed in the system; D. Rapidly cool the finished product obtained in step C to room temperature.

7. The preparation process of the skin whitening and moisturizing cream according to claim 6, characterized in that: Step D is to rapidly cool the sample to room temperature by spraying an appropriate amount of liquid nitrogen.