A controllable coating device, method and product for braided large-caliber artificial blood vessels

Abstract

The present invention relates to the technical field of biomedical material manufacturing. The present invention provides a controllable coating device for braided large-caliber artificial blood vessels, including a feed bottle, a feed pump, an electrode wire retracting device I, a guide wheel I, an electrode wire, an electrode wire liquid supply tank, a blood vessel fixing seat I, a ring-shaped receiving electrode, a blood vessel fixing seat II, an electrode wire cleaning tank, a guide wheel II, an electrode wire retracting device II, a high-voltage power supply, a mounting base, a linear module, a grounding device, and a liquid supply pipe; the electrode wire can achieve reciprocating motion under the drive of the electrode wire retracting device I and the electrode wire retracting device II, and the controllable coating of the braided large-caliber artificial blood vessel is achieved through the electric field. In addition to the above-mentioned single coating solution coating, the present device can also replace the coating solution at any time to achieve different solutions for each layer, or implement zoned coating on the artificial blood vessel according to functional requirements. The present invention also relates to products made by the above-mentioned controllable coating device and method.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedical material manufacturing, and in particular to a controllable coating device, method and product for braided large-caliber artificial blood vessels. Background Art

[0002] Cardiovascular disease is the number one killer of human health, and its morbidity and mortality rates are much higher than other diseases. Vascular transplantation is one of the effective means of treating cardiovascular disease. Vascular substitutes include autologous blood vessels, xenogeneic blood vessels, allogeneic blood vessels and artificial blood vessels. Autologous blood vessels have many problems such as limited vascular supply sites, infection and diameter mismatch, and the sources of xenogeneic blood vessels and allogeneic blood vessels are severely limited. Therefore, artificial blood vessels are the main way to solve vascular replacement. At present, the most frequently used artificial blood vessel materials are mainly artificial blood vessels made of woven fabrics such as polyester and polytetrafluoroethylene. However, woven artificial blood vessels are made of yarns through weaving, knitting and other methods, and there are a large number of pores, which cause bleeding when blood flows through. Now, in order to solve the bleeding problem of woven blood vessels, it is necessary to coat the inner wall, outer wall or inner and outer walls of the artificial blood vessels at the same time to block the pores of the vascular braid itself to achieve a non-bleeding effect.

[0003] In the prior art, invention patent CN117324138A discloses a device and method for ultrafine coating inside a braided artificial blood vessel. The device includes an electrostatic spraying device, a storage box, a metal slide bar, a collection box, and an exhaust device on the collection box; a connector for fixing the artificial blood vessel horizontally is provided on the storage box and the collection box; a movable electrostatic metal ring connected to a grounding device is sleeved on the metal slide bar, and the electrostatic metal ring is also sleeved on the outside of the artificial blood vessel; a metal wire extending to the inside of the artificial blood vessel and connected to an external electrostatic generator is provided in the collection box. When the device is used, the metal wire and the electrostatic metal ring form an electric field inside and outside the braided artificial blood vessel, so that the negatively charged mist beads sprayed by the electrostatic spraying device move in a directional manner inside the blood vessel toward its surface, and the mist beads are controlled by the horizontal movement of the electrostatic metal ring, so that the inner surface of the braided artificial blood vessel is coated, and a uniform ultrafine coating is obtained, which provides a new way for the internal coating of the braided artificial blood vessel.

[0004] However, the droplets sprayed by the electrostatic spray gun are inconsistently dispersed on the inner wall of the artificial blood vessel to be coated under the influence of the external environment, resulting in inconsistent electrostatic coating thickness; the solution itself is negatively charged, and the metal wire in the blood vessel is also negatively charged. When the droplets enter the blood vessel, the coating thickness of the blood vessel near the electrostatic spray device end will be greater than the coating thickness of the blood vessel at the other end due to repulsion; during the electrostatic coating process by spraying droplets with an electrostatic spray gun, a large number of droplets will contact the inner wall of the blood vessel and rebound and escape from the inner wall under the action of surface tension, and enter the collection box with the excess droplets, resulting in a large amount of waste of coating liquid and low coating efficiency. In addition, this invention device cannot achieve regional coating of artificial blood vessels. Summary of the invention

[0005] In order to solve the above-mentioned problems in the prior art, the present invention provides a controllable coating method, equipment and product for a braided large-caliber artificial blood vessel, providing a new approach for the layered and segmented refined coating of a braided large-caliber artificial blood vessel.

[0006] A controllable coating device for braided large-caliber artificial blood vessels comprises a feed bottle, a feed pump, an electrode wire retracting device I, a guide wheel I, an electrode wire, an electrode wire liquid supply tank, a blood vessel fixing seat I, an annular receiving electrode, a blood vessel fixing seat II, an electrode wire cleaning tank, a guide wheel II, an electrode wire retracting device II, a high-voltage power supply, a mounting base, a linear module, a grounding device, and a liquid supply pipe; wherein the electrode wire retracting device I and the electrode wire retracting device II are respectively fixed on both sides of the mounting base, the linear module is installed on the mounting surface of the mounting base, the blood vessel fixing seat I and the blood vessel fixing seat II are respectively fixed on both ends of the linear module, the electrode wire liquid supply tank is installed on the blood vessel fixing seat I, and the electrode wire cleaning tank is installed on the blood vessel fixing seat II, and the amount of liquid on the electrode wire is controlled by using spinning solutions of different concentrations to control the amount of coating on the inner wall of the artificial blood vessel. The electrode wire can be a single wire or a strand of wire to provide a liquid volume; the annular receiving electrode is installed on the linear module slide, the annular receiving electrode is connected to the grounding device, the guide wheel I and the guide wheel II are respectively installed on both sides of the mounting surface of the mounting base, the guide wheel II is connected to a high-voltage power supply, the artificial blood vessel passes through the annular receiving electrode and is respectively installed on the blood vessel fixing seat I and the blood vessel fixing seat II, and the positions of the blood vessel fixing seat I and the blood vessel fixing seat II on the linear module are adjusted to keep the artificial blood vessel horizontal and fix the positions of the blood vessel fixing seat I and the blood vessel fixing seat II, the electrode wire passes through the guide wheel I, the electrode wire liquid supply tank, the blood vessel fixing seat I, the artificial blood vessel, the blood vessel fixing seat II, the electrode wire cleaning tank, and the guide wheel II from the electrode wire retracting device I in turn, and is fixed on the electrode wire retracting device II; the feed pump, the electrode wire retracting device I and the electrode wire retracting device II can all rotate forward and reverse.

[0007] According to another aspect of the present invention, a controllable coating method for a braided large-caliber artificial blood vessel is provided, wherein the braided large-caliber artificial blood vessel is coated with the above-mentioned coating device for a braided large-caliber artificial blood vessel, comprising the following steps:

[0008] S1. Install the artificial blood vessel to be coated on the blood vessel fixing seat I and the blood vessel fixing seat II through the annular receiving electrode, adjust the positions of the blood vessel fixing seat I and the blood vessel fixing seat II on the linear module to keep the artificial blood vessel horizontal, and fix the positions of the blood vessel fixing seat I and the blood vessel fixing seat II;

[0009] S2, pull the electrode wire out of the electrode wire taking-up and releasing device Ⅰ, pass it through the guide wheel Ⅰ, the electrode wire liquid supply tank, the blood vessel fixing seat Ⅰ, the artificial blood vessel, the blood vessel fixing seat Ⅱ, the electrode wire cleaning tank, the guide wheel Ⅱ in sequence, and fix it on the electrode wire taking-up and releasing device Ⅱ;

[0010] S3. Driven by the electrode wire retracting and releasing device I and the electrode wire retracting and releasing device II, the electrode wire passes through the electrode wire liquid supply groove and carries the coating solution into the lumen of the artificial blood vessel to be coated. The annular receiving electrode is driven to the starting position of the coating of the inner wall of the artificial blood vessel by the linear module. The high-voltage power supply is started and the annular receiving electrode starts to move back and forth at a uniform speed in the blood vessel interval to be coated. The coating solution is evenly spun to the coating area of ​​the inner wall of the blood vessel in the form of electrospinning. After the spinning of the solution attached to the surface of the electrode wire is completed, the high-voltage power supply stops, and the electrode wire retracting and releasing device I and the electrode wire retracting and releasing device II continue to drive the electrode wire to operate. The electrode wire area that has been spun enters the electrode wire cleaning groove to clean the coating solution remaining on the surface of the electrode wire. The electrode wire and the annular receiving electrode continue the above actions until the required number of coatings are completed.

[0011] S4. After the coating is completed, the feed pump rotates in the reverse direction to draw the coating solution in the electrode wire feed tank back into the feed bottle, and the electrode wire collecting and releasing device I and the electrode wire collecting and releasing device II are driven in the reverse direction to recover the electrode wire into the electrode wire collecting and releasing device I;

[0012] S5. Remove the artificial blood vessel and complete the coating of the artificial blood vessel product.

[0013] The coating solution is replaced before step S5, and steps S3 and S4 are repeated to obtain artificial blood vessel products with different coatings.

[0014] According to another aspect of the present invention, there is also provided a product obtained by the controllable coating method of a braided large-caliber artificial blood vessel, wherein the product is made by the controllable coating method described above.

[0015] Beneficial Effects

[0016] 1. The present invention controls the amount of liquid carried by the electrode wire by controlling the concentration of the coating solution. The coating solution attached to the surface of the electrode wire is coated onto the inner wall of the artificial blood vessel through the electrostatic field formed. This coating method can control the amount of coating on the inner wall of the artificial blood vessel.

[0017] 2. The feed pump and electrode wire retracting device involved in the present invention can rotate forward and reversely, and is provided with an electrode wire cleaning tank, so that the coating solution can be replaced during the coating process so that each layer is coated with a different coating solution.

[0018] 3. The annular receiving electrode involved in the present invention is installed on a linear module, so that the starting position and reciprocating range of the annular receiving electrode can be controlled to achieve regional coating of different solutions inside the artificial blood vessel.

[0019] 4. The equipment of the present invention has a simple structure, is easy to operate, and has a built-in electrode wire cleaning function. During coating, the coating amount and coating range can be accurately controlled each time. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the overall structure of the device of the present invention;

[0021] In the figure: 1-feeding bottle; 2-feeding pump; 3-electrode wire taking-up and releasing device Ⅰ; 4-guide wheel Ⅰ; 5-electrode wire; 6-electrode wire liquid supply tank; 7-blood vessel fixing seat Ⅰ; 8-artificial blood vessel; 9-annular receiving electrode; 10-blood vessel fixing seat Ⅱ; 11-electrode wire cleaning tank; 12-guide wheel Ⅱ; 13-electrode wire taking-up and releasing device Ⅱ; 14-high voltage power supply; 15-mounting base; 16-linear module; 17-grounding device; 18-liquid supply pipe. DETAILED DESCRIPTION

[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the described examples are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making any creative work are within the scope of protection of the present invention.

[0023] Example 1

[0024] A controllable coating device for braided large-caliber artificial blood vessels, comprising a feed bottle 1, a feed pump 2, an electrode wire retracting device Ⅰ3, a guide wheel Ⅰ4, an electrode wire 5, an electrode wire liquid supply tank 6, a blood vessel fixing seat Ⅰ7, an annular receiving electrode 9, a blood vessel fixing seat Ⅱ10, an electrode wire cleaning tank 11, a guide wheel Ⅱ12, an electrode wire retracting device Ⅱ13, a high-voltage power supply 14, a mounting base 15, a linear module 16, a grounding device 17, and a liquid supply pipe 18; wherein the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 are respectively fixed on both sides of the mounting base 15, the linear module 16 is installed on the mounting surface of the mounting base 15, the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 are respectively fixed on both ends of the linear module 16, the electrode wire liquid supply tank 6 is installed on the blood vessel fixing seat Ⅰ7, the electrode wire cleaning tank 11 is installed on the blood vessel fixing seat Ⅱ10, the annular receiving electrode 9 is installed on the linear module On the slide 16, the annular receiving electrode 9 is connected to the grounding device 17, the guide wheel Ⅰ4 and the guide wheel Ⅱ12 are respectively installed on both sides of the mounting surface of the mounting base 15, the guide wheel Ⅱ12 is connected to the high-voltage power supply 14, the artificial blood vessel 8 passes through the annular receiving electrode 9 and is respectively installed on the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10, and the positions of the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 on the linear module 16 are adjusted to keep the artificial blood vessel 8 horizontal, and the positions of the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 are fixed, the electrode wire 5 passes through the guide wheel Ⅰ4, the electrode wire supply tank 6, the blood vessel fixing seat Ⅰ7, the artificial blood vessel 8, the blood vessel fixing seat Ⅱ10, the electrode wire cleaning tank 11, and the guide wheel Ⅱ12 from the electrode wire retracting device Ⅰ3 in sequence, and is fixed on the electrode wire retracting device Ⅱ13; the feed pump 2, the electrode wire retracting device Ⅰ3, and the electrode wire retracting device Ⅱ13 can all rotate forward and reverse.

[0025] A controllable coating method for a braided large-caliber artificial blood vessel, the method using the above-mentioned controllable coating device and comprising the following steps:

[0026] S1, install the artificial blood vessel 8 to be coated on the blood vessel fixing seat I7 and the blood vessel fixing seat II10 respectively through the annular receiving electrode 9, and adjust the positions of the blood vessel fixing seat I7 and the blood vessel fixing seat II10 on the linear module 16 to keep the artificial blood vessel 8 horizontal, and fix the positions of the blood vessel fixing seat I7 and the blood vessel fixing seat II10;

[0027] S2, pull the electrode wire 5 out of the electrode wire taking-up and releasing device Ⅰ3, pass it through the guide wheel Ⅰ4, the electrode wire liquid supply tank 6, the blood vessel fixing seat Ⅰ7, the artificial blood vessel 8, the blood vessel fixing seat Ⅱ10, the electrode wire cleaning tank 11, the guide wheel Ⅱ12 in sequence, and fix it on the electrode wire taking-up and releasing device Ⅱ13;

[0028] S3, prepare a single coating solution T1, and place the coating solution in a supply bottle 1;

[0029] S4, start the power supply, the electrode wire 5 is driven by the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13, the electrode wire 5 passes through the electrode wire liquid supply groove 6 with the coating solution into the lumen of the artificial blood vessel 8 to be coated, the annular receiving electrode 9 is driven to the left end point of the artificial blood vessel 8 by the linear module 16, and the reciprocating range of the annular receiving electrode 9 is set to the entire length of the artificial blood vessel 8 to be coated, the high-voltage power supply 14 is started, and the annular receiving electrode 9 starts to move at a uniform speed in the section of the artificial blood vessel 8 to be coated, and the coating solution is evenly spun to the coating area of ​​the inner wall of the artificial blood vessel 8 in the form of electrospinning. After the coating solution attached to the surface of the electrode wire 5 is spun, the high-voltage power supply 14 stops, the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 continue to drive the electrode wire 5 to operate, and the area of ​​the electrode wire 5 that has been spun enters the electrode wire cleaning groove 11 to clean the coating solution remaining on the surface of the electrode wire 5; the electrode wire 5 and the annular receiving electrode 9 continue the above actions until the number of coatings reaches 20 times;

[0030] S5. After the coating is completed, the feed pump 2 rotates in the reverse direction to draw the coating solution in the electrode wire liquid supply tank 6 back into the feed bottle 1, and the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 drive in the reverse direction to recycle the electrode wire 5 into the electrode wire retracting device Ⅰ3, and the artificial blood vessel 8 is removed, thus completing the production of the single solution coated artificial blood vessel 8 product.

[0031] Example 2

[0032] A controllable coating device for braided large-caliber artificial blood vessels, comprising a feed bottle 1, a feed pump 2, an electrode wire retracting device Ⅰ3, a guide wheel Ⅰ4, an electrode wire 5, an electrode wire liquid supply tank 6, a blood vessel fixing seat Ⅰ7, an annular receiving electrode 9, a blood vessel fixing seat Ⅱ10, an electrode wire cleaning tank 11, a guide wheel Ⅱ12, an electrode wire retracting device Ⅱ13, a high-voltage power supply 14, a mounting base 15, a linear module 16, a grounding device 17, and a liquid supply pipe 18; wherein the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 are respectively fixed on both sides of the mounting base 15, the linear module 16 is installed on the mounting surface of the mounting base 15, the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 are respectively fixed on both ends of the linear module 16, the electrode wire liquid supply tank 6 is installed on the blood vessel fixing seat Ⅰ7, the electrode wire cleaning tank 11 is installed on the blood vessel fixing seat Ⅱ10, the annular receiving electrode 9 is installed on the linear module On the slide 16, the annular receiving electrode 9 is connected to the grounding device 17, the guide wheel Ⅰ4 and the guide wheel Ⅱ12 are respectively installed on both sides of the mounting surface of the mounting base 15, the guide wheel Ⅱ12 is connected to the high-voltage power supply 14, the artificial blood vessel 8 passes through the annular receiving electrode 9 and is respectively installed on the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10, and the positions of the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 on the linear module 16 are adjusted to keep the artificial blood vessel 8 horizontal, and the positions of the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 are fixed, the electrode wire 5 passes through the guide wheel Ⅰ4, the electrode wire supply tank 6, the blood vessel fixing seat Ⅰ7, the artificial blood vessel 8, the blood vessel fixing seat Ⅱ10, the electrode wire cleaning tank 11, and the guide wheel Ⅱ12 from the electrode wire retracting device Ⅰ3 in sequence, and is fixed on the electrode wire retracting device Ⅱ13; the feed pump 2, the electrode wire retracting device Ⅰ3, and the electrode wire retracting device Ⅱ13 can all rotate forward and reverse.

[0033] A controllable coating method for a braided large-caliber artificial blood vessel, the method using the above-mentioned controllable coating device and comprising the following steps:

[0034] S1, install the artificial blood vessel 8 to be coated on the blood vessel fixing seat I7 and the blood vessel fixing seat II10 respectively through the annular receiving electrode 9, and adjust the positions of the blood vessel fixing seat I7 and the blood vessel fixing seat II10 on the linear module 16 to keep the artificial blood vessel 8 horizontal, and fix the positions of the blood vessel fixing seat I7 and the blood vessel fixing seat II10;

[0035] S2, pull the electrode wire 5 out of the electrode wire taking-up and releasing device Ⅰ3, pass it through the guide wheel Ⅰ4, the electrode wire liquid supply tank 6, the blood vessel fixing seat Ⅰ7, the artificial blood vessel 8, the blood vessel fixing seat Ⅱ10, the electrode wire cleaning tank 11, the guide wheel Ⅱ12 in sequence, and fix it on the electrode wire taking-up and releasing device Ⅱ13;

[0036] S3, prepare coating solution T1 and coating solution T2, first put coating solution T1 into supply bottle 1, and keep coating solution T2 aside;

[0037] S4, start the power supply, the electrode wire 5 is driven by the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13, the electrode wire 5 passes through the electrode wire liquid supply groove 6 with the coating solution into the lumen of the artificial blood vessel 8 to be coated, the annular receiving electrode 9 is driven to the left end point of the artificial blood vessel 8 by the linear module 16, and the reciprocating range of the annular receiving electrode 9 is set to the entire length of the artificial blood vessel 8 to be coated, the high-voltage power supply 14 is started, and the annular receiving electrode 9 starts to move at a uniform speed in the section of the artificial blood vessel 8 to be coated, and the coating solution is evenly spun to the coating area of ​​the inner wall of the artificial blood vessel 8 in the form of electrospinning. After the spinning of the solution attached to the surface of the electrode wire 5 is completed, the high-voltage power supply 14 stops, the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 continue to drive the electrode wire 5 to operate, and the area of ​​the electrode wire 5 that has been spun enters the electrode wire cleaning groove 11 to clean the coating solution remaining on the surface of the electrode wire 5; the electrode wire 5 and the annular receiving electrode 9 continue the above actions until the number of coatings reaches 10 times;

[0038] S5. After the coating is completed, the feed pump 2 rotates in the opposite direction to draw the coating solution in the electrode wire supply tank 6 back into the feed bottle 1, and the feed bottle 1 is cleaned. After cleaning, the coating solution T2 is placed into the feed bottle 1; then step S4 is repeated, and the coating is repeated 10 times.

[0039] S6. After the coating is completed, the feed pump 2 rotates in the opposite direction to draw the coating solution in the electrode wire supply tank 6 back into the feed bottle 1, and the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 drive in the opposite direction to retract the electrode wire 5 into the electrode wire retracting device Ⅰ3, and the artificial blood vessel 8 is removed, thus completing the production of the artificial blood vessel 8 product with layered coatings of different coating solutions.

[0040] Example 3

[0041] A controllable coating device for braided large-caliber artificial blood vessels, comprising a feed bottle 1, a feed pump 2, an electrode wire retracting device Ⅰ3, a guide wheel Ⅰ4, an electrode wire 5, an electrode wire liquid supply tank 6, a blood vessel fixing seat Ⅰ7, an annular receiving electrode 9, a blood vessel fixing seat Ⅱ10, an electrode wire cleaning tank 11, a guide wheel Ⅱ12, an electrode wire retracting device Ⅱ13, a high-voltage power supply 14, a mounting base 15, a linear module 16, a grounding device 17, and a liquid supply pipe 18; wherein the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 are respectively fixed on both sides of the mounting base 15, the linear module 16 is installed on the mounting surface of the mounting base 15, the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 are respectively fixed on both ends of the linear module 16, the electrode wire liquid supply tank 6 is installed on the blood vessel fixing seat Ⅰ7, the electrode wire cleaning tank 11 is installed on the blood vessel fixing seat Ⅱ10, the annular receiving electrode 9 is installed on the linear module On the slide 16, the annular receiving electrode 9 is connected to the grounding device 17, the guide wheel Ⅰ4 and the guide wheel Ⅱ12 are respectively installed on both sides of the mounting surface of the mounting base 15, the guide wheel Ⅱ12 is connected to the high-voltage power supply 14, the artificial blood vessel 8 passes through the annular receiving electrode 9 and is respectively installed on the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10, and the positions of the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 on the linear module 16 are adjusted to keep the artificial blood vessel 8 horizontal, and the positions of the blood vessel fixing seat Ⅰ7 and the blood vessel fixing seat Ⅱ10 are fixed, the electrode wire 5 passes through the guide wheel Ⅰ4, the electrode wire supply tank 6, the blood vessel fixing seat Ⅰ7, the artificial blood vessel 8, the blood vessel fixing seat Ⅱ10, the electrode wire cleaning tank 11, and the guide wheel Ⅱ12 from the electrode wire retracting device Ⅰ3 in sequence, and is fixed on the electrode wire retracting device Ⅱ13; the feed pump 2, the electrode wire retracting device Ⅰ3, and the electrode wire retracting device Ⅱ13 can all rotate forward and reverse.

[0042] A controllable coating method for a braided large-caliber artificial blood vessel, the method using the above-mentioned controllable coating device and comprising the following steps:

[0043] S1, install the artificial blood vessel 8 to be coated on the blood vessel fixing seat I7 and the blood vessel fixing seat II10 respectively through the annular receiving electrode 9, and adjust the positions of the blood vessel fixing seat I7 and the blood vessel fixing seat II10 on the linear module 16 to keep the artificial blood vessel 8 horizontal, and fix the positions of the blood vessel fixing seat I7 and the blood vessel fixing seat II10;

[0044] S2, pull the electrode wire 5 out of the electrode wire taking-up and releasing device Ⅰ3, pass it through the guide wheel Ⅰ4, the electrode wire liquid supply tank 6, the blood vessel fixing seat Ⅰ7, the artificial blood vessel 8, the blood vessel fixing seat Ⅱ10, the electrode wire cleaning tank 11, the guide wheel Ⅱ12 in sequence, and fix it on the electrode wire taking-up and releasing device Ⅱ13;

[0045] S3, prepare coating solution T1 and coating solution T2, first put coating solution T1 into supply bottle 1, and keep coating solution T2 aside;

[0046] S4, start the power supply, the electrode wire 5 is driven by the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13, the electrode wire 5 passes through the electrode wire liquid supply groove 6 with the coating solution into the lumen of the artificial blood vessel 8 to be coated, the annular receiving electrode 9 is driven to the left end point of the artificial blood vessel 8 by the linear module 16, firstly, the annular receiving electrode 9 is set to be able to travel back and forth only within the range from the left end point of the artificial blood vessel 8 to the right to one-third of the left end point, start the high-voltage power supply 14 and the annular receiving electrode 9 starts to move at a uniform speed in the section of the artificial blood vessel 8 to be coated, and the coating solution is evenly spun to the coating area of ​​the inner wall of the artificial blood vessel 8 in the form of electrospinning, after the coating solution attached to the surface of the electrode wire 5 is spun, the high-voltage power supply 14 stops, the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 continue to drive the electrode wire 5 to operate, the area of ​​the electrode wire 5 that has been spun enters the electrode wire cleaning groove 11, and the coating solution remaining on the surface of the electrode wire 5 is cleaned; the electrode wire 5 and the annular receiving electrode 9 continue the above actions until the coating times are 20 times;

[0047] S5, driving the annular receiving electrode 9 to the right end point of the artificial blood vessel 8 through the linear module 16, setting the annular receiving electrode 9 to be able to reciprocate only within the distance from the right end point of the artificial blood vessel 8 to the left of one third of the right end point, and the rest is referred to step S4;

[0048] S6. After the coating is completed, the feed pump 2 rotates in the opposite direction to draw the coating solution in the electrode wire supply tank 6 back into the feed bottle 1, and the feed bottle 1 is cleaned; after cleaning, the coating solution T2 is put into the feed bottle 1, and the annular receiving electrode 9 is driven to a position one-third of the distance from the right end point of the artificial blood vessel 8 through the linear module 16, and the annular receiving electrode 9 is set to be able to travel back and forth only within the range between a position one-third of the distance from the right end point of the artificial blood vessel 8 and a position one-third of the distance from the left end point, and then step S4 is repeated until the coating is repeated 20 times;

[0049] S7. After the coating is completed, the feed pump 2 rotates in the reverse direction to draw the coating solution in the electrode wire supply tank 6 back into the feed bottle 1, and the electrode wire retracting device Ⅰ3 and the electrode wire retracting device Ⅱ13 drive in the reverse direction to recycle the electrode wire 5 into the electrode wire retracting device Ⅰ3, and the artificial blood vessel 8 is removed, thus completing the production of the artificial blood vessel 8 product with different functional solution partition coatings.

Claims

1. A controllable coating device for braided large-caliber artificial blood vessels, characterized in that: It includes a feeding bottle, a feeding pump, an electrode wire retracting device I, a guide wheel I, an electrode wire, an electrode wire liquid supply tank, a blood vessel fixing seat I, an annular receiving electrode, a blood vessel fixing seat II, an electrode wire cleaning tank, a guide wheel II, an electrode wire retracting device II, a high-voltage power supply, a mounting base, a linear module, a grounding device, and a liquid supply pipe; wherein the electrode wire retracting device I and the electrode wire retracting device II are respectively fixed on both sides of the mounting base, the linear module is installed on the mounting surface of the mounting base, the blood vessel fixing seat I and the blood vessel fixing seat II are respectively fixed on both ends of the linear module, the electrode wire liquid supply tank is installed on the blood vessel fixing seat I, the electrode wire cleaning tank is installed on the blood vessel fixing seat II, and the annular receiving electrode is installed On the linear module slide, the annular receiving electrode is connected to the grounding device, guide wheel I and guide wheel II are respectively installed on both sides of the mounting surface of the mounting base, guide wheel II is connected to a high-voltage power supply, the artificial blood vessel is installed on the vascular fixing seat I and vascular fixing seat II respectively through the annular receiving electrode, and the positions of vascular fixing seat I and vascular fixing seat II on the linear module are adjusted to keep the artificial blood vessel horizontal and fix the positions of vascular fixing seat I and vascular fixing seat II, the electrode wire passes through guide wheel I, electrode wire liquid supply tank, vascular fixing seat I, artificial blood vessel, vascular fixing seat II, electrode wire cleaning tank, guide wheel II from electrode wire retracting device I in sequence, and is fixed on electrode wire retracting device II.

2. The controllable coating device for braided large-caliber artificial blood vessels according to claim 1 is characterized in that: The feed pump, the electrode wire taking-up and releasing device I, and the electrode wire taking-up and releasing device II can all rotate forward and reverse.

3. A controllable coating method for braided large-caliber artificial blood vessels, characterized in that: The method uses a controllable coating device according to any one of claims 1-2, and comprises the following steps: S1. Install the artificial blood vessel to be coated on the blood vessel fixing seat I and the blood vessel fixing seat II through the annular receiving electrode, adjust the positions of the blood vessel fixing seat I and the blood vessel fixing seat II on the linear module to keep the artificial blood vessel horizontal, and fix the positions of the blood vessel fixing seat I and the blood vessel fixing seat II; S2, pull the electrode wire out of the electrode wire taking-up and releasing device Ⅰ, pass it through the guide wheel Ⅰ, the electrode wire liquid supply tank, the blood vessel fixing seat Ⅰ, the artificial blood vessel, the blood vessel fixing seat Ⅱ, the electrode wire cleaning tank, the guide wheel Ⅱ in sequence, and fix it on the electrode wire taking-up and releasing device Ⅱ; S3. Driven by the electrode wire retracting and releasing device I and the electrode wire retracting and releasing device II, the electrode wire passes through the electrode wire liquid supply groove and carries the coating solution into the lumen of the artificial blood vessel to be coated. The annular receiving electrode is driven to the starting position of the coating of the inner wall of the artificial blood vessel by the linear module. The high-voltage power supply is started and the annular receiving electrode starts to move back and forth at a uniform speed in the blood vessel interval to be coated. The coating solution is evenly spun to the coating area of ​​the inner wall of the blood vessel in the form of electrospinning. After the spinning of the solution attached to the surface of the electrode wire is completed, the high-voltage power supply stops, and the electrode wire retracting and releasing device I and the electrode wire retracting and releasing device II continue to drive the electrode wire to operate. The electrode wire area that has been spun enters the electrode wire cleaning groove to clean the coating solution remaining on the surface of the electrode wire. The electrode wire and the annular receiving electrode continue the above actions until the required number of coatings are completed. S4. After the coating is completed, the feed pump rotates in the reverse direction to draw the coating solution in the electrode wire feed tank back into the feed bottle, and the electrode wire collecting and releasing device I and the electrode wire collecting and releasing device II are driven in the reverse direction to recover the electrode wire into the electrode wire collecting and releasing device I; S5. Remove the artificial blood vessel and complete the coating of the artificial blood vessel product.

4. The controllable coating method for braided large-caliber artificial blood vessels according to claim 3 is characterized in that: The coating solution is replaced before step S5, and steps S3 and S4 are repeated to obtain artificial blood vessel products with different coatings.

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