A traditional Chinese medicine composition for treating postoperative cough of lung cancer

Abstract

The application belongs to the field of biological medicine, and particularly relates to a traditional Chinese medicine composition for treating postoperative cough of lung cancer. Specifically disclosed is a traditional Chinese medicine composition for treating postoperative cough of lung cancer, which is prepared from the following weight parts of traditional Chinese medicinal material raw materials: cassia twig 6-30 parts, white peony root 6-30 parts, raw ginger 6-20 parts, fried licorice 6-20 parts, magnolia officinalis 6-25 parts, apricot kernel 6-25 parts, ginseng 6-25 parts, jujube 6-25 parts, schisandra chinensis 6-25 parts, periostracum cicadae 6-25 parts, pinellia ternate 6-25 parts, spongy moth 6-30 parts; the present application is used for treating postoperative cough of lung cancer patients by adding flavor, and the total effective rate reaches 93.9%; the present application has a remarkable effect in the treatment of postoperative cough of lung cancer patients.

Description

Technical Field

[0001] This invention belongs to the field of biomedicine, specifically relating to a traditional Chinese medicine composition for treating postoperative cough in lung cancer patients. Background Technology

[0002] Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. Surgery is a crucial treatment for early and mid-stage lung cancer. Tumor resection combined with systematic lymph node dissection is a primary surgical approach that achieves good therapeutic results. However, postoperative complications are a significant concern, with postoperative cough (CAP) occurring in 25%-50% of cases. While moderate postoperative coughing can promote lung re-expansion and sputum clearance to prevent lung infection, persistent postoperative coughing increases postoperative pain, the risk of air leakage from the drainage tube after removal, and can even affect sleep, communication, and quality of life. It also delays surgical wound healing, prolongs the recovery period, increases physical and psychological suffering, and may even threaten a patient's life.

[0003] The mechanisms underlying community-acquired lung cancer (CAP) remain highly controversial, and there is no consensus on its treatment. CAP remains a common adverse reaction after lung cancer surgery, and the lack of effective treatment poses a serious challenge for both doctors and patients. Therefore, there is an urgent clinical need for CAP treatment. Effective CAP treatment can not only alleviate patient suffering and improve postoperative quality of life, but also reduce surgical risks and improve overall treatment outcomes.

[0004] The main ingredients of Guizhi Jia Houpu Xingzi Tang (Cinnamon Twig Decoction with Magnolia Bark and Apricot Kernel) are cinnamon twig, magnolia bark, angelica root, prepared licorice root, white peony root, apricot kernel, silkworm pupae, ginger, and jujube. Cinnamon twig in this formula can unblock the meridians, relieve muscle tension, and expel wind-evil from the exterior. White peony root can nourish yin and astringe the yin that has leaked out. Ginger is pungent and warm, assisting cinnamon twig in dispersing external pathogens and also harmonizing the stomach and stopping vomiting. Jujube can invigorate qi, replenish the middle jiao, nourish the spleen, and generate fluids. Licorice root can harmonize the properties of the other herbs. Guizhi Jia Houpu Xingzi Tang is mainly used to treat exterior wind-cold syndrome with deficiency of the exterior. It has the effects of relieving qi stagnation, releasing exterior pathogens, and harmonizing the yin and yang. Patients present with symptoms such as headache, fever, sweating, aversion to wind, nasal congestion, and dry retching. The addition of magnolia bark and apricot kernel can relieve cough and asthma. For external wind-cold syndrome, Guizhi Tang (Cinnamon Twig Decoction) should be used for treatment. However, if the patient mistakenly uses purgative drugs, the external symptoms are not relieved, and the purgation causes the internal pathogens to rise upwards, resulting in wheezing. In this case, Guizhi Jia Houpu Xingzi Tang (Cinnamon Twig Decoction with Magnolia Bark and Apricot Kernel) can be used to lower qi and relieve wheezing. This formula utilizes Guizhi Tang to relieve muscle tension, dispel cold, and harmonize the Ying and Wei (nutritive and defensive qi). Magnolia bark is added to resolve phlegm and lower qi, while apricot kernel warms the lungs, stops cough, and relieves wheezing. Together with magnolia bark, they have the effects of lowering qi, promoting qi circulation, and resolving phlegm. Clinically, Guizhi Jia Houpu Xingzi Tang can be used to treat various colds, acute and chronic bronchitis, bronchial asthma, viral pneumonia, and other conditions with similar symptoms.

[0005] Traditional Chinese medicine (TCM) has proven effective in treating coughs. Clinical studies show that TCM can effectively treat coughs associated with conditions such as cough-variant asthma, post-infectious asthma, and allergic asthma. TCM also possesses unique advantages in improving postoperative recovery after lung cancer surgery. In clinical application, it can reduce complications, improve patients' quality of life, and promote postoperative recovery. TCM believes that lung cancer surgery damages the tangible flesh, bones, and muscles, as well as the intangible essence and qi, further depleting the body's yin and yang qi and blood. The Ming Dynasty medical text *Introduction to Medicine* records, "In reality, it is a deficiency of both qi and blood." Postoperative lung cancer patients often experience symptoms such as cough, sputum production, fatigue, shortness of breath, chest and back pain, dry mouth, abdominal distension, loss of appetite, poor sleep, spontaneous sweating, and night sweats. Research has found that postoperative lung cancer often presents with a deficiency of the root and an excess of the branch, with the deficiency mainly being qi and yin deficiency and lung and spleen qi deficiency; the excess is mainly phlegm obstructing the lungs and qi stagnation and blood stasis. Qi and Yin deficiency syndrome persists throughout the entire postoperative progression of lung cancer. Phlegm obstruction of the lungs and qi stagnation and blood stasis are the main pathogenesis, requiring the simultaneous regulation of qi and blood and consideration of both deficiency and excess. Summary of the Invention

[0006] This research team summarized and analyzed the TCM symptoms of CAP patients. They found that although the patients presented with dry cough and little phlegm, resembling a Yin deficiency cough, the corresponding Yin deficiency manifestations such as red tongue with little coating, dry mouth and throat, excessive thirst, irritability, constipation, and night sweats were not common. Instead, symptoms such as shortness of breath, fatigue, excessive sweating, aversion to cold, chest tightness, and coughing triggered by throat itching were more prevalent. Combined with the specific environmental factors of depletion of vital energy during surgery and the low temperature of the surgical environment making patients susceptible to wind-cold invasion, this aligns with the diagnostic characteristics of Guizhi Jia Houpu Xingzi Tang (Cinnamon Twig Decoction with Magnolia Bark and Apricot Kernel) – a combination of depletion of vital energy, external invasion of wind-cold, pathogenic factors trapped externally, and Qi reversal in the chest. Furthermore, due to the deficiency of vital energy and the internal stagnation of pathogenic factors residing in the Taiyang and Shaoyang meridians, this formula was modified to address these factors, resulting in good clinical efficacy. Based on this, the present invention was completed.

[0007] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating postoperative cough in lung cancer patients. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 6-30 parts of cinnamon twig, 6-30 parts of white peony root, 6-20 parts of fresh ginger, 6-20 parts of prepared licorice root, 6-25 parts of magnolia bark, 6-25 parts of apricot kernel, 6-25 parts of ginseng, 6-25 parts of jujube, 6-25 parts of schisandra fruit, 6-25 parts of cicada slough, 6-25 parts of ginger-processed pinellia tuber, and 6-30 parts of silkworm pupae.

[0008] Preferably, the traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicinal materials: 6-20 parts of cinnamon twig, 6-20 parts of white peony root, 6-10 parts of fresh ginger, 6-10 parts of prepared licorice root, 6-15 parts of magnolia bark, 6-15 parts of apricot kernel, 6-15 parts of ginseng, 6-15 parts of jujube, 6-15 parts of schisandra fruit, 6-15 parts of cicada slough, 6-15 parts of ginger-processed pinellia tuber, and 6-20 parts of silkworm pupae.

[0009] Preferably, the traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicinal materials: 10-15 parts of cinnamon twig, 10-15 parts of white peony root, 6-8 parts of fresh ginger, 6-8 parts of prepared licorice root, 6-13 parts of magnolia bark, 6-13 parts of apricot kernel, 6-13 parts of ginseng, 6-13 parts of jujube, 6-13 parts of schisandra fruit, 6-13 parts of cicada slough, 6-13 parts of ginger-processed pinellia tuber, and 6-15 parts of silkworm pupae.

[0010] Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10 parts cinnamon twig, 10 parts white peony root, 6 parts fresh ginger, 6 parts prepared licorice root, 12 parts magnolia bark, 10 parts apricot kernel, 10 parts ginseng, 9 parts jujube, 10 parts schisandra fruit, 6 parts cicada slough, 10 parts ginger-processed pinellia tuber, and 10 parts silkworm.

[0011] Secondly, the present invention provides a preparation of a traditional Chinese medicine composition for treating postoperative cough in lung cancer patients. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 6-30 parts of cinnamon twig, 6-30 parts of white peony root, 6-20 parts of ginger, 6-20 parts of prepared licorice root, 6-25 parts of magnolia bark, 6-25 parts of apricot kernel, 6-25 parts of ginseng, 6-25 parts of jujube, 6-25 parts of schisandra fruit, 6-25 parts of cicada slough, 6-25 parts of ginger-processed pinellia, and 6-30 parts of silkworm.

[0012] Furthermore, the pharmaceutical formulation comprises a pharmaceutical composition for treating postoperative cough in lung cancer patients and pharmaceutically acceptable excipients.

[0013] Furthermore, the excipients are pharmaceutical excipients that enhance the efficacy of the active pharmaceutical ingredient, reduce its toxicity, and / or alleviate its side effects.

[0014] Furthermore, the pharmaceutical excipients may be liquid excipients or solid excipients.

[0015] Furthermore, the preparation of the traditional Chinese medicine composition can be a paste, pill, elixir, decoction, granule, capsule, powder, tablet, etc.

[0016] Thirdly, the present invention provides the application of a traditional Chinese medicine composition in the preparation of a medicament for treating postoperative cough in lung cancer patients.

[0017] The main indications for this formula are: postoperative cough after lung resection, which is diagnosed as Taiyang stroke with deficiency of vital energy. Clinical manifestations include cough with little sputum, shortness of breath, spontaneous sweating or excessive sweating, or fatigue, wheezing, aversion to wind, pale red tongue with thin white coating.

[0018] Guizhi Houpu Xingzi Tang (Cinnamon Twig, Magnolia Bark, and Apricot Kernel Decoction) appears in Article 43 of the *Shanghan Lun* (Treatise on Cold Damage): "In Taiyang disease, if there is slight wheezing after purging, it indicates that the exterior syndrome has not been resolved; Guizhi Jia Houpu Xingzi Tang is the main treatment." Article 18 states, "For wheezing patients, Guizhi Tang is recommended, with the addition of Magnolia Bark and Apricot Kernel." The original text describes it as being used for patients with pre-existing wheezing who experience a worsening of their wheezing due to external wind-cold pathogens, accompanied by exterior syndromes, or for those whose exterior is deficient and susceptible to wind-cold pathogens, leading to wheezing and shortness of breath due to improper purging. Cheng Wuji believed: "If there is severe wheezing after purging, it indicates that the interior qi is too weak, the pathogenic qi has penetrated inward, and the body's vital energy is about to collapse. If there is slight wheezing after purging, it indicates that the interior qi is rising upward, the pathogenic qi cannot penetrate inward, and the condition remains on the exterior. Guizhi Tang is given to resolve the exterior, with the addition of Magnolia Bark and Apricot Kernel to purge the rebellious qi."

[0019] In this formula, cinnamon twig and white peony root regulate the body's vital energy and eliminate cold and heat; magnolia bark, apricot kernel, and schisandra fruit lower qi, resolve phlegm, astringe the lungs, and stop coughing; ginseng, jujube, and licorice root tonify the body and replenish deficiency; cicada slough and silkworm expel stagnant heat and relieve spasms; and pinellia and ginger descend rebellious qi and harmonize the stomach. This formula enhances the tonifying and strengthening effects of the Cinnamon Twig, Magnolia Bark, and Apricot Kernel Decoction, addressing postoperative patients and those with qi and blood deficiency. It adds heat-clearing and spasm-relieving herbs, considering the internal and external wind-evil disturbances in the pathogenesis of cough. The addition of pinellia addresses the irregular ascending and descending of qi in the lungs and stomach, and the addition of schisandra fruit targets lung deficiency and qi deficiency. With these additions, the formula comprehensively addresses the symptoms of qi depletion, external wind-cold invasion, pathogenic factors trapped externally, and qi rebellion in the chest in postoperative lung cancer patients.

[0020] Beneficial effects

[0021] This invention targets postoperative cough in lung cancer patients, specifically those diagnosed with Taiyang stroke and deficiency of vital energy, clinically presenting with cough with little sputum, shortness of breath, spontaneous sweating or excessive sweating, or fatigue, wheezing, aversion to wind, and a pale red tongue with a thin white coating. This formula, with added ingredients, addresses these symptoms to treat postoperative cough in lung cancer patients, achieving a total effective rate of 93.9%. This formula demonstrates significant efficacy in treating postoperative cough in lung cancer patients. Detailed Implementation

[0022] The specific embodiments of the present invention will be further described below. It should be noted that these descriptions are for the purpose of aiding understanding the present invention, but do not constitute a limitation thereof. Furthermore, the technical features involved in the embodiments described below can be combined with each other as long as they do not conflict with each other.

[0023] Unless otherwise specified, the experimental methods used in the following embodiments are conventional methods, and the experimental materials used in the following embodiments are all available through conventional commercial channels.

[0024] Example 1

[0025] 1.1 Research Plan

[0026] A single-arm study was conducted, and 33 patients were included according to the inclusion criteria. They were treated with a modified Guizhi Houpu Xingzi Decoction for 2 weeks, and the corresponding indicators were observed according to the experimental milestones.

[0027] 1.2 Research Subjects

[0028] Patients who underwent lung surgery for lung cancer within the past 6 months and developed a cough after the surgery.

[0029] 1. Inclusion criteria:

[0030] (1) Age 18 years and above.

[0031] (2) Patients who have undergone segmentectomy or lobectomy for cancer within the past 6 months;

[0032] (3) Patients who do not respond or respond poorly to conventional antitussive medication after one week of administration;

[0033] (4) Eastern Cooperative Oncology Group (ECOG) status score of 0-2;

[0034] (5) It conforms to the TCM diagnosis of "Taiyang stroke with deficiency of vital energy".

[0035] 2. Exclusion criteria:

[0036] (1) Patients receiving adjuvant chemotherapy;

[0037] (2) Patients diagnosed with acute respiratory disease within 6 months;

[0038] (3) Patients diagnosed with bronchial asthma or bronchiectasis within 1 year;

[0039] (4) Patients taking angiotensin-converting enzyme inhibitors;

[0040] (5) Patients diagnosed with pneumonia by chest X-ray or CT scan;

[0041] (6) Subjects with a known prior allergy to any component of the investigational drug;

[0042] (7) Patients with acute or chronic infections requiring treatment (active hepatitis A, B and C viruses, human immunodeficiency virus, tuberculosis);

[0043] (8) Women who are pregnant or breastfeeding;

[0044] (9) Patients who have participated in other drug or medical device clinical trials within the past 6 months;

[0045] (10) Alcoholics;

[0046] (11) Individuals whom the researchers deem unsuitable for the study.

[0047] 1.3 Observation Indicators:

[0048] Changes in TCM syndrome scale scores before and after treatment: The TCM syndrome scale can reflect changes in TCM syndromes, help assess changes in the subject's overall condition, including cough, and reflect changes in the patient's quality of life. The TCM syndrome quantification scale is shown in Table 1.

[0049] Table 1. Quantitative Table of Traditional Chinese Medicine Symptom Grading for Cough

[0050]

[0051] Cough Quality of Life Questionnaire Scoring: The severity of cough is scored according to the cough scoring scale. The cough scoring scale is shown in Table 2.

[0052] Table 2 Cough Scoring Table

[0053]

[0054] Cough Visual Analogue Scale (VAS) scoring: Participants marked their cough on a 100 mm linear VAS, with 0 indicating "no cough" and 100 indicating "most severe cough".

[0055] 1.4 Efficacy Evaluation:

[0056] Refer to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine Drugs".

[0057] Based on the improvement of symptoms and signs before and after treatment, and the changes in TCM symptom scores, the therapeutic effects are divided into four categories, as follows:

[0058] Cure: Clinical symptoms and signs have basically disappeared, and the score has decreased by ≥95% before and after treatment.

[0059] Significant effect: Clinical symptoms and signs are significantly improved, with 70% ≤ a decrease in scores <95 before and after treatment.

[0060] Effective: Clinical symptoms and signs improved, with 30% ≤ score reduction <70% before and after treatment.

[0061] Ineffective: Clinical symptoms and signs do not improve or worsen, and the score decreases by <30% before and after treatment.

[0062] 1.5 Preparation of the prescription:

[0063] Prescription: Cinnamon twig 10g, white peony root 10g, fresh ginger 6g, prepared licorice root 6g, magnolia bark 12g, apricot kernel 10g, ginseng 10g, jujube 9g, schisandra fruit 10g, cicada slough 6g, ginger-processed pinellia 10g, silkworm 10g.

[0064] Preparation of decoction: Soak the above-mentioned Chinese herbs in 400 ml of tap water for 1 hour, decoct twice, adding 300 ml of water for the second decoction. After each decoction boils, decoct for 30 minutes and collect 150-200 ml of decoction. Mix the two decoctions and take them in two divided doses half an hour after breakfast and dinner. One dose per day for two consecutive weeks.

[0065] 1.6 Research Data and Results:

[0066] A total of 33 patients with postoperative cough were enrolled. All patients underwent thoracoscopic surgery, and the duration of cough ranged from 1 week to 10 months, with a median duration of 1.5 (1-4) months. Among them, there were 9 males and 24 females, with a male-to-female ratio of 1:2.7; the mean age was 55.7 ± 12.2 years, and the median age was 57 (48-64) years; among them, 10 patients underwent partial lobectomy, 14 underwent segmentectomy, 7 underwent lobectomy, and 2 underwent left / right lung resection; 23 patients underwent right lung surgery, and 10 underwent left lung surgery; 27 patients underwent single-site resection, and 6 underwent multi-site resection; 16 patients underwent systematic lymph node dissection, 16 underwent localized lymph node dissection, and 1 patient did not undergo lymph node dissection.

[0067] The efficacy evaluation results of 33 patients were as follows: 0 cases were cured, 10 cases showed significant improvement, 21 cases were effective, and 2 cases were ineffective, with a total effective rate of 93.9% (see Table 3).

[0068] Traditional Chinese Medicine syndrome score: The mean score before treatment was 7.18±2.98 points, and the mean score after treatment was 3.06±1.66 points. See Table 4 for details.

[0069] Cough quality of life questionnaire score: mean score before treatment 2.7±1.47, mean score after treatment 0.45±0.67, see Table 4 for details.

[0070] Cough visual analog scale score: mean score before treatment was 4.45±2.14, mean score after treatment was 1.24±1.35 (see Table 4 for details).

[0071] Table 3 Clinical efficacy data

[0072]

[0073] Table 4. Preliminary Clinical Data of Modified Guizhi Houpu Xingzi Decoction

[0074]

[0075]

[0076] Example 2 Typical Case

[0077] Wang Li*, female, 42 years old, consulted on April 24, 2023. She underwent right lower lobectomy and lymph node dissection on April 7, 2023. Postoperative pathology report was available. She has had a persistent cough since the surgery, which worsens with stimulation. She also experiences throat discomfort, little sputum, chest discomfort, chest pain on the operated side, and excessive sweating with activity. Shortness of breath and fatigue are not significant. Her appetite is fair, bowel movements are normal, and sleep is fair. Her tongue is pale red with a thin white coating, and her pulse is slightly wiry. The first prescription included: Cinnamon Twig 10g, White Peony Root 10g, Magnolia Bark 12g, Apricot Kernel 10g, Fresh Ginger 6g, Ginger-processed Pinellia 10g, Schisandra Fruit 6g, Prepared Licorice Root 6g, Ginseng 6g, Jujube 9g, Bombyx Batryticatus 10g, and Cicada Slough 6g. After 14 doses, the patient returned for a follow-up visit on May 9, 2023. The cough had significantly decreased, but discomfort behind the sternum and in the throat remained. The patient experienced excessive sweating after activity and slight fatigue. The previous prescription was modified by adding 30g of floating wheat, 20g of raw astragalus, 10g of yam, and 6g of five-spice powder. Another 7 doses were prescribed. On May 16, 2023, the patient returned for a follow-up visit. The cough had disappeared, and the discomfort in the throat and behind the sternum had significantly decreased. Excessive sweating and fatigue after activity remained. The patient was then treated with a modified version of Yu Ping Feng San (Jade Screen Powder) plus Oyster Shell Powder.

[0078] Zhang Zhi*: Female, 60 years old, consulted on April 10, 2023. She underwent a right upper lobectomy with lymph node dissection on March 2, 2023. One week post-surgery, she developed a cough that has persisted to this day. Symptoms include intermittent cough, accompanied by chest tightness, a feeling of phlegm in the throat, poor sleep, fatigue, significant shortness of breath, slight sweating, fair appetite, and normal bowel movements. Her tongue is pale red with a thin white coating, and her pulse is deep, thready, and slightly wiry. The prescription included: Cinnamon twig 12g, White peony root 10g, Magnolia bark 10g, Apricot kernel 10g, Ginseng 15g, Prepared licorice root 6g, Jujube 10g, Ginger-processed Pinellia ternata 10g, Schisandra chinensis 6g, Silkworm 10g, Cicada slough 6g, and Fresh ginger 6g. After 14 doses, she returned for a follow-up visit two weeks later. Her cough had significantly decreased, phlegm had also reduced, and fatigue and shortness of breath had improved. However, the feeling of fullness and distension in the epigastrium, chest tightness, and poor sleep had worsened. Add 10g of Trichosanthes kirilowii, 6g of Coptis chinensis, and 6g of Aucklandia lappa to the above prescription, and administer 7 more doses. On May 2nd, at the follow-up visit, the cough was basically the same as before, with some white phlegm remaining. The chest tightness and fullness in the epigastrium had improved, and sleep had also improved. The prescription was modified by reducing Trichosanthes kirilowii, Allium macrostemon, Schisandra chinensis, Aucklandia lappa, Ostrea gigas, and Psoralea corylifolia, and adding 10g each of Perilla frutescens, Raphanus sativus, stir-fried mustard seed, Bupleurum chinense, Scutellaria baicalensis, Cyperus rotundus, and Albizia julibrissin bark. Administer 7 more doses. On May 19th, at the follow-up visit, the cough had basically disappeared, with no chest tightness, slightly poor sleep, unstable emotions, and still easy sweating after activity. The prescription was modified by adding Ostrea gigas powder to Xiaoyao Wan for adjustment.

[0079] Liao Liang*, female, 49 years old, consulted on April 28, 2023. The patient underwent left lower lobe resection and lymph node dissection on March 2, 2023. Post-operatively, she requested regular follow-up examinations and did not receive any other treatment. Her symptoms included cough with shortness of breath and wheezing for nearly two months, night sweats, epigastric fullness after meals, poor sleep, and slight fatigue. Her tongue was pale red with a thin white coating, and her pulse was thready and wiry. Prescription: Cinnamon twig 6g, Magnolia officinalis 10g, Apricot kernel 6g, White peony root 10g, Prepared licorice root 10g, Schisandra chinensis 6g, Ginger-processed Pinellia ternata 12g, Ginseng 10g, Bombyx mori 10g, Cicada slough 6g, Jujube 15g, Fresh ginger 6g. After 7 doses, she returned for a follow-up visit. The cough had subsided, the night sweats had disappeared, and the night sweats had improved. However, she still experienced shortness of breath and wheezing, and slight epigastric fullness after meals. The prescription was modified by adding Psoralea corylifolia 10g and pollen 15g, and she was prescribed another 7 doses. On May 4, 2023, the patient returned for a follow-up visit. All symptoms were not obvious, except for shortness of breath after activity and occasional chest tightness. The patient continued to receive treatment based on syndrome differentiation.

Claims

1. A traditional Chinese medicine composition for treating postoperative cough in lung cancer patients, the composition being prepared from the following parts by weight of traditional Chinese medicinal materials: 6-30 parts of cinnamon twig, 6-30 parts of white peony root, 6-20 parts of fresh ginger, 6-20 parts of prepared licorice root, 6-25 parts of magnolia bark, 6-25 parts of apricot kernel, 6-25 parts of ginseng, 6-25 parts of jujube, 6-25 parts of schisandra fruit, 6-25 parts of cicada slough, 6-25 parts of ginger-processed pinellia tuber, and 6-30 parts of silkworm pupae.

2. The traditional Chinese medicine composition for treating postoperative cough in lung cancer patients as described in claim 1, characterized in that, The traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicinal materials: 6-20 parts of cinnamon twig, 6-20 parts of white peony root, 6-10 parts of fresh ginger, 6-10 parts of prepared licorice root, 6-15 parts of magnolia bark, 6-15 parts of apricot kernel, 6-15 parts of ginseng, 6-15 parts of jujube, 6-15 parts of schisandra fruit, 6-15 parts of cicada slough, 6-15 parts of ginger-processed pinellia tuber, and 6-20 parts of silkworm pupae.

3. The traditional Chinese medicine composition for treating postoperative cough in lung cancer patients as described in claim 1, characterized in that, The traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicinal materials: 10 parts of cinnamon twig, 10 parts of white peony root, 6 parts of ginger, 6 parts of prepared licorice root, 12 parts of magnolia bark, 10 parts of apricot kernel, 10 parts of ginseng, 9 parts of jujube, 10 parts of schisandra fruit, 6 parts of cicada slough, 10 parts of ginger-processed pinellia tuber, and 10 parts of silkworm pupae.

4. A traditional Chinese medicine preparation made from the traditional Chinese medicine composition for treating postoperative cough in lung cancer patients as described in claim 1, characterized in that, The traditional Chinese medicine preparations are one or more of the following: pastes, pills, elixirs, decoctions, granules, capsules, powders, and / or tablets.

5. A traditional Chinese medicine preparation made from the traditional Chinese medicine composition as described in claim 4, characterized in that, The traditional Chinese medicine preparation consists of a drug composition for treating postoperative cough in lung cancer patients and pharmaceutically acceptable excipients; the excipients are pharmaceutical excipients that enhance the efficacy of the main drug, reduce toxicity, and / or alleviate side effects; the pharmaceutical excipients are liquid excipients and / or solid excipients.

6. The use of the traditional Chinese medicine composition as described in claim 1 in the preparation of a medicament for treating postoperative cough in lung cancer patients, characterized in that, The postoperative cough of lung cancer patients is diagnosed as a case of Taiyang stroke with deficiency of vital energy. Clinically, this presents with cough with little sputum, shortness of breath, spontaneous sweating or excessive sweating, or fatigue, wheezing, aversion to wind, and a pale red tongue with a thin white coating.

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